HME
MCID: HMN001
MIFTS: 30

Human Monocytic Ehrlichiosis (HME)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Human Monocytic Ehrlichiosis

MalaCards integrated aliases for Human Monocytic Ehrlichiosis:

Name: Human Monocytic Ehrlichiosis 12 74 20 54 15
Human Ehrlichial Infection, Human Monocytic Type 20
Ehrlichiosis Chafeensis 12
Hme 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0050026

Summaries for Human Monocytic Ehrlichiosis

Disease Ontology : 12 An ehrlichiosis that results in infection located in monocyte or located in macrophage, has material basis in Ehrlichia chaffeensis, which is transmitted by black-legged tick (Ixodes scapularis), transmitted by western black-legged tick (Ixodes pacificus) or transmitted by castor bean tick (Ixodes ricinus). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.

MalaCards based summary : Human Monocytic Ehrlichiosis, also known as human ehrlichial infection, human monocytic type, is related to ehrlichiosis and human granulocytic anaplasmosis. An important gene associated with Human Monocytic Ehrlichiosis is DNASE1L1 (Deoxyribonuclease 1 Like 1), and among its related pathways/superpathways are Phagosome and Tuberculosis. Affiliated tissues include monocytes, liver and kidney.

Wikipedia : 74 Human monocytotropic ehrlichiosis is a form of ehrlichiosis associated with Ehrlichia chaffeensis. This... more...

Related Diseases for Human Monocytic Ehrlichiosis

Diseases related to Human Monocytic Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 ehrlichiosis 31.0 TXNL1 HSPD1 ETF1 DNASE1L1 ANKRD46
2 human granulocytic anaplasmosis 29.9 RAB5A KRTAP26-1 HSPD1 ETF1 DNASE1L1
3 hemimegalencephaly 11.0
4 exanthem 10.4
5 neutropenia 10.3
6 thrombocytopenia 10.3
7 rocky mountain spotted fever 10.2
8 hemophagocytic lymphohistiocytosis 10.2
9 spotted fever 10.2
10 pancytopenia 10.2
11 diarrhea 10.2
12 lymphopenia 10.2
13 headache 10.2
14 secondary hemophagocytic lymphohistiocytosis 10.2
15 cat-scratch disease 10.2 HSPD1 ANKRD46
16 hereditary multiple exostoses 10.1
17 hereditary multiple osteochondromas 10.1
18 ataxia and polyneuropathy, adult-onset 10.0
19 retinitis pigmentosa 30 10.0
20 granulomatosis with polyangiitis 10.0
21 retinitis pigmentosa 44 10.0
22 analbuminemia 10.0
23 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
24 sensorineural hearing loss 10.0
25 adult respiratory distress syndrome 10.0
26 lyme disease 10.0
27 dysentery 10.0
28 cholestasis 10.0
29 acute kidney failure 10.0
30 congestive heart failure 10.0
31 myocarditis 10.0
32 appendicitis 10.0
33 macrophage activation syndrome 10.0
34 splenomegaly 10.0
35 sudden sensorineural hearing loss 10.0
36 seizure disorder 10.0
37 glanders 10.0 MYD88 HSPD1
38 deafness, autosomal dominant 69 10.0 GRPEL1 CLPB
39 pancreatic ductal adenocarcinoma 10.0
40 chronic purulent otitis media 9.9 TLR2 ETF1
41 cataract 8, multiple types 9.9 RAB5A EEA1
42 oculoglandular tularemia 9.9 TLR2 CLPB
43 fibrosis of extraocular muscles, congenital, 1 9.9
44 medulloblastoma 9.9
45 lung cancer 9.9
46 patent ductus arteriosus 1 9.9
47 infant gynecomastia 9.9
48 gynecomastia 9.9
49 pneumothorax 9.9
50 adenocarcinoma 9.9

Graphical network of the top 20 diseases related to Human Monocytic Ehrlichiosis:



Diseases related to Human Monocytic Ehrlichiosis

Symptoms & Phenotypes for Human Monocytic Ehrlichiosis

Drugs & Therapeutics for Human Monocytic Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Human Monocytic Ehrlichiosis

Genetic Tests for Human Monocytic Ehrlichiosis

Anatomical Context for Human Monocytic Ehrlichiosis

MalaCards organs/tissues related to Human Monocytic Ehrlichiosis:

40
Monocytes, Liver, Kidney, Lymph Node, Heart, Pancreas, Skin

Publications for Human Monocytic Ehrlichiosis

Articles related to Human Monocytic Ehrlichiosis:

(show top 50) (show all 216)
# Title Authors PMID Year
1
Potential value of major antigenic protein 2 for serological diagnosis of heartwater and related ehrlichial infections. 61 54
10066656 1999
2
Comparative Analysis of Genome of Ehrlichia sp. HF, a Model Bacterium to Study Fatal Human Ehrlichiosis. 61
33407096 2021
3
Human Monocytic Ehrlichiosis, Mexico City, Mexico. 61
33219798 2020
4
Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation. 61
32358827 2020
5
Incidence and treatment of hemophagocytic lymphohistiocytosis in hospitalized children with Ehrlichia infection. 61
32706439 2020
6
Multiple Ehrlichia chaffeensis Genes Critical for Its Persistent Infection in a Vertebrate Host Are Identified by Random Mutagenesis Coupled with In Vivo Infection Assessment. 61
32747600 2020
7
Verification of mono- and mixed contaminations transmitting agents tick-borne infections. 61
33245658 2020
8
An Entry-Triggering Protein of Ehrlichia Is a New Vaccine Candidate against Tick-Borne Human Monocytic Ehrlichiosis. 61
32723916 2020
9
Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation. 61
32317318 2020
10
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. 61
31677968 2020
11
M1 and M2 Macrophages Polarization via mTORC1 Influences Innate Immunity and Outcome of Ehrlichia Infection. 61
32719831 2020
12
From Tick Bite to Heart Failure: Ehrlichial Myocarditis. 61
32159128 2019
13
mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis. 61
31575880 2019
14
[Molecular-genetic monitoring as the basis of modern epidemiological surveillance of tick-borne infections.] 61
31408595 2019
15
Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in Unique Ehrlichia chaffeensis Sigma 32-Dependent Promoter Activity of dnaK Gene. 61
31428069 2019
16
Emerging Roles of Autophagy and Inflammasome in Ehrlichiosis. 61
31134081 2019
17
Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura. 61
30279260 2018
18
Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan. 61
30419740 2018
19
Protein and DNA synthesis demonstrated in cell-free Ehrlichia chaffeensis organisms in axenic medium. 61
29915240 2018
20
Impact of Three Different Mutations in Ehrlichia chaffeensis in Altering the Global Gene Expression Patterns. 61
29670161 2018
21
Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection. 61
29643078 2018
22
Complete Genome Sequence of Ehrlichia canis Strain YZ-1, Isolated from a Beagle with Fever and Thrombocytopenia. 61
29496840 2018
23
Large-scale health disparities associated with Lyme disease and human monocytic ehrlichiosis in the United States, 2007-2013. 61
30261027 2018
24
Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis. 61
30274412 2018
25
Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics. 61
29372907 2018
26
Ehrlichia chaffeensis and Its Invasin EtpE Block Reactive Oxygen Species Generation by Macrophages in a DNase X-Dependent Manner. 61
29162709 2017
27
A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis. 61
29150636 2017
28
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. 61
28846788 2017
29
Detection of Borrelia miyamotoi and other tick-borne pathogens in human clinical specimens and Ixodes scapularis ticks in New York State, 2012-2015. 61
28131594 2017
30
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. 61
27575459 2016
31
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase. 61
27541856 2016
32
Sequence determinants spanning -35 motif and AT-rich spacer region impacting Ehrlichia chaffeensis Sigma 70-dependent promoter activity of two differentially expressed p28 outer membrane protein genes. 61
27402867 2016
33
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. 61
27758794 2016
34
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. 61
27388158 2016
35
Use of Peptide-Based Enzyme-Linked Immunosorbent Assay followed by Immunofluorescence Assay To Document Ehrlichia chaffeensis as a Cause of Febrile Illness in Nicaragua. 61
27053675 2016
36
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. 61
27308282 2016
37
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. 61
27088220 2016
38
[EPIDEMIOLOGIC SITUATION BY NATURAL-FOCI INFECTIONS IN THE CRIMEA FEDERAL DISTRICT IN 2014-2015]. 61
27228673 2016
39
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. 61
26918212 2016
40
NK Cell-Mediated Regulation of Protective Memory Responses against Intracellular Ehrlichial Pathogens. 61
27092553 2016
41
Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host. 61
26841025 2016
42
Comparative Genomics of the Zoonotic Pathogen Ehrlichia chaffeensis Reveals Candidate Type IV Effectors and Putative Host Cell Targets. 61
28180111 2016
43
EtpE Binding to DNase X Induces Ehrlichial Entry via CD147 and hnRNP-K Recruitment, Followed by Mobilization of N-WASP and Actin. 61
26530384 2015
44
The perils of country life: human monocytic ehrlichiosis. 61
25912197 2015
45
Attenuated Mutants of Ehrlichia chaffeensis Induce Protection against Wild-Type Infection Challenge in the Reservoir Host and in an Incidental Host. 61
25916990 2015
46
A Coxiella-like endosymbiont is a potential vitamin source for the Lone Star tick. 61
25618142 2015
47
Mutations in Ehrlichia chaffeensis Causing Polar Effects in Gene Expression and Differential Host Specificities. 61
26186429 2015
48
Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake. 61
25425236 2014
49
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. 61
25332563 2014
50
Experimental infection of Rhipicephalus sanguineus with Ehrlichia chaffeensis. 61
24894131 2014

Variations for Human Monocytic Ehrlichiosis

Expression for Human Monocytic Ehrlichiosis

Search GEO for disease gene expression data for Human Monocytic Ehrlichiosis.

Pathways for Human Monocytic Ehrlichiosis

Pathways related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 TLR2 RAB5A EEA1
2 11.28 TLR2 RAB5A MYD88 HSPD1 EEA1
3 10.89 TLR2 MYD88 HSPD1
4 10.72 TLR2 MYD88
5 10.48 TLR2 MYD88

GO Terms for Human Monocytic Ehrlichiosis

Cellular components related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 8.92 RAB5A HSPD1 EEA1 ANKFY1

Biological processes related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.54 TLR2 MYD88 HSPD1
2 lipopolysaccharide-mediated signaling pathway GO:0031663 9.4 TLR2 MYD88
3 positive regulation of interleukin-6 production GO:0032755 9.33 TLR2 MYD88 HSPD1
4 early endosome to late endosome transport GO:0045022 9.32 RAB5A EEA1
5 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.26 HSPD1 COA8
6 viral RNA genome replication GO:0039694 8.96 RAB5A EEA1
7 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.8 TLR2 MYD88 HSPD1

Molecular functions related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 TLR2 HSPD1
2 Toll-like receptor binding GO:0035325 8.62 TLR2 MYD88

Sources for Human Monocytic Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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