HME
MCID: HMN001
MIFTS: 30

Human Monocytic Ehrlichiosis (HME)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Human Monocytic Ehrlichiosis

MalaCards integrated aliases for Human Monocytic Ehrlichiosis:

Name: Human Monocytic Ehrlichiosis 12 74 52 54 15
Human Ehrlichial Infection, Human Monocytic Type 52
Ehrlichiosis Chafeensis 12
Hme 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050026

Summaries for Human Monocytic Ehrlichiosis

Disease Ontology : 12 An ehrlichiosis that results in infection located in monocyte or located in macrophage, has material basis in Ehrlichia chaffeensis, which is transmitted by black-legged tick (Ixodes scapularis), transmitted by western black-legged tick (Ixodes pacificus) or transmitted by castor bean tick (Ixodes ricinus). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.

MalaCards based summary : Human Monocytic Ehrlichiosis, also known as human ehrlichial infection, human monocytic type, is related to rocky mountain spotted fever and human granulocytic anaplasmosis. An important gene associated with Human Monocytic Ehrlichiosis is DNASE1L1 (Deoxyribonuclease 1 Like 1), and among its related pathways/superpathways are Phagosome and Tuberculosis. Affiliated tissues include monocytes, liver and kidney.

Wikipedia : 74 Human monocytotropic ehrlichiosis (HME) is a form of ehrlichiosis associated with Ehrlichia chaffeensis.... more...

Related Diseases for Human Monocytic Ehrlichiosis

Diseases related to Human Monocytic Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 rocky mountain spotted fever 30.3 PCDHGB7 HSPD1
2 human granulocytic anaplasmosis 30.3 RAB5A MMP12 KRTAP26-1 HSPD1
3 ehrlichiosis 30.1 TXNL1 MMP12 HSPD1 ETF1 DNASE1L1 CD4
4 hemimegalencephaly 11.3
5 thrombocytopenia 10.4
6 hereditary multiple exostoses 10.3
7 hereditary multiple osteochondromas 10.3
8 exanthem 10.3
9 neutropenia 10.3
10 pancreatic ductal adenocarcinoma 10.2
11 endemic typhus 10.1 PCDHGB7 HSPD1
12 bacillary angiomatosis 10.1 HSPD1 CD4
13 hemophagocytic lymphohistiocytosis 10.1
14 spotted fever 10.1
15 pancytopenia 10.1
16 diarrhea 10.1
17 lymphopenia 10.1
18 secondary hemophagocytic lymphohistiocytosis 10.1
19 opportunistic bacterial infectious disease 10.1 HSPD1 CD4
20 nocardiosis 10.1 HSPD1 CD4
21 chancroid 10.1 HSPD1 CD4
22 glanders 10.1 HSPD1 CD4
23 medulloblastoma 10.1
24 patent ductus arteriosus 1 10.1
25 infant gynecomastia 10.1
26 gynecomastia 10.1
27 pneumothorax 10.1
28 pancreatic adenocarcinoma 10.1
29 pneumonia 10.1
30 hip subluxation 10.1
31 osteochondroma 10.1
32 arterial thoracic outlet syndrome 10.1
33 xerophthalmia 10.1 DNASE1L1 CD4
34 bartonellosis 10.1 HSPD1 CD4
35 cervical adenitis 10.1 HSPD1 CD4
36 deafness, autosomal dominant 69 10.0 HSPD1 GRPEL1 CLPB
37 ataxia and polyneuropathy, adult-onset 10.0
38 retinitis pigmentosa 30 10.0
39 granulomatosis with polyangiitis 10.0
40 retinitis pigmentosa 44 10.0
41 analbuminemia 10.0
42 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
43 sensorineural hearing loss 10.0
44 adult respiratory distress syndrome 10.0
45 lyme disease 10.0
46 visual epilepsy 10.0
47 dysentery 10.0
48 leukemia 10.0
49 cholestasis 10.0
50 acute kidney failure 10.0

Graphical network of the top 20 diseases related to Human Monocytic Ehrlichiosis:



Diseases related to Human Monocytic Ehrlichiosis

Symptoms & Phenotypes for Human Monocytic Ehrlichiosis

Drugs & Therapeutics for Human Monocytic Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Human Monocytic Ehrlichiosis

Genetic Tests for Human Monocytic Ehrlichiosis

Anatomical Context for Human Monocytic Ehrlichiosis

MalaCards organs/tissues related to Human Monocytic Ehrlichiosis:

40
Monocytes, Liver, Kidney, Testes, T Cells, Lymph Node, Heart

Publications for Human Monocytic Ehrlichiosis

Articles related to Human Monocytic Ehrlichiosis:

(show top 50) (show all 209)
# Title Authors PMID Year
1
Potential value of major antigenic protein 2 for serological diagnosis of heartwater and related ehrlichial infections. 54 61
10066656 1999
2
Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation. 61
32358827 2020
3
Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation. 61
32317318 2020
4
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. 61
31677968 2020
5
From Tick Bite to Heart Failure: Ehrlichial Myocarditis. 61
32159128 2019
6
mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis. 61
31575880 2019
7
[Molecular-genetic monitoring as the basis of modern epidemiological surveillance of tick-borne infections.] 61
31408595 2019
8
Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in Unique Ehrlichia chaffeensis Sigma 32-Dependent Promoter Activity of dnaK Gene. 61
31428069 2019
9
Emerging Roles of Autophagy and Inflammasome in Ehrlichiosis. 61
31134081 2019
10
Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura. 61
30279260 2018
11
Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan. 61
30419740 2018
12
Protein and DNA synthesis demonstrated in cell-free Ehrlichia chaffeensis organisms in axenic medium. 61
29915240 2018
13
Impact of Three Different Mutations in Ehrlichia chaffeensis in Altering the Global Gene Expression Patterns. 61
29670161 2018
14
Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection. 61
29643078 2018
15
Complete Genome Sequence of Ehrlichia canis Strain YZ-1, Isolated from a Beagle with Fever and Thrombocytopenia. 61
29496840 2018
16
Large-scale health disparities associated with Lyme disease and human monocytic ehrlichiosis in the United States, 2007-2013. 61
30261027 2018
17
Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis. 61
30274412 2018
18
Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics. 61
29372907 2018
19
Ehrlichia chaffeensis and Its Invasin EtpE Block Reactive Oxygen Species Generation by Macrophages in a DNase X-Dependent Manner. 61
29162709 2017
20
A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis. 61
29150636 2017
21
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. 61
28846788 2017
22
Detection of Borrelia miyamotoi and other tick-borne pathogens in human clinical specimens and Ixodes scapularis ticks in New York State, 2012-2015. 61
28131594 2017
23
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. 61
27575459 2016
24
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase. 61
27541856 2016
25
Sequence determinants spanning -35 motif and AT-rich spacer region impacting Ehrlichia chaffeensis Sigma 70-dependent promoter activity of two differentially expressed p28 outer membrane protein genes. 61
27402867 2016
26
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. 61
27758794 2016
27
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. 61
27388158 2016
28
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. 61
27308282 2016
29
Use of Peptide-Based Enzyme-Linked Immunosorbent Assay followed by Immunofluorescence Assay To Document Ehrlichia chaffeensis as a Cause of Febrile Illness in Nicaragua. 61
27053675 2016
30
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. 61
27088220 2016
31
[EPIDEMIOLOGIC SITUATION BY NATURAL-FOCI INFECTIONS IN THE CRIMEA FEDERAL DISTRICT IN 2014-2015]. 61
27228673 2016
32
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. 61
26918212 2016
33
NK Cell-Mediated Regulation of Protective Memory Responses against Intracellular Ehrlichial Pathogens. 61
27092553 2016
34
Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host. 61
26841025 2016
35
Comparative Genomics of the Zoonotic Pathogen Ehrlichia chaffeensis Reveals Candidate Type IV Effectors and Putative Host Cell Targets. 61
28180111 2016
36
EtpE Binding to DNase X Induces Ehrlichial Entry via CD147 and hnRNP-K Recruitment, Followed by Mobilization of N-WASP and Actin. 61
26530384 2015
37
The perils of country life: human monocytic ehrlichiosis. 61
25912197 2015
38
Attenuated Mutants of Ehrlichia chaffeensis Induce Protection against Wild-Type Infection Challenge in the Reservoir Host and in an Incidental Host. 61
25916990 2015
39
A Coxiella-like endosymbiont is a potential vitamin source for the Lone Star tick. 61
25618142 2015
40
Mutations in Ehrlichia chaffeensis Causing Polar Effects in Gene Expression and Differential Host Specificities. 61
26186429 2015
41
Ehrlichia chaffeensis proliferation begins with NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake. 61
25425236 2014
42
Macrophage activation syndrome secondary to human monocytic ehrlichiosis. 61
25332563 2014
43
[Prevalence, prevention and treatment of human monocytic ehrlichiosis in China]. 61
25376694 2014
44
Experimental infection of Rhipicephalus sanguineus with Ehrlichia chaffeensis. 61
24894131 2014
45
Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis. 61
24491580 2014
46
Bayesian spatio-temporal analysis and geospatial risk factors of human monocytic ehrlichiosis. 61
24992684 2014
47
Ehrlichia chaffeensis infection in the reservoir host (white-tailed deer) and in an incidental host (dog) is impacted by its prior growth in macrophage and tick cell environments. 61
25303515 2014
48
A case of human monocytic ehrlichiosis in Serbia. 61
24684037 2014
49
Rural residents in China are at increased risk of exposure to tick-borne pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis. 61
24877080 2014
50
Myocarditis after trimethoprim/sulfamethoxazole treatment for ehrlichiosis. 61
24274783 2013

Variations for Human Monocytic Ehrlichiosis

Expression for Human Monocytic Ehrlichiosis

Search GEO for disease gene expression data for Human Monocytic Ehrlichiosis.

Pathways for Human Monocytic Ehrlichiosis

Pathways related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.68 TLR2 RAB5A EEA1
2 11.28 TLR2 RAB5A MYD88 HSPD1 EEA1
3 10.89 TLR2 MYD88 HSPD1
4 10.65 TLR2 MYD88
5 10.48 TLR2 MYD88

GO Terms for Human Monocytic Ehrlichiosis

Cellular components related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.26 TLR2 RAB5A HSPD1 CD4
2 early endosome GO:0005769 9.02 RAB5A HSPD1 EEA1 CD4 ANKFY1

Biological processes related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-12 production GO:0032735 9.4 TLR2 HSPD1
2 positive regulation of interleukin-10 production GO:0032733 9.37 TLR2 HSPD1
3 positive regulation of T cell activation GO:0050870 9.32 HSPD1 CD4
4 early endosome to late endosome transport GO:0045022 9.26 RAB5A EEA1
5 viral RNA genome replication GO:0039694 9.16 RAB5A EEA1
6 positive regulation of interleukin-6 production GO:0032755 9.13 TLR2 MYD88 HSPD1
7 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.8 TLR2 MYD88 HSPD1

Molecular functions related to Human Monocytic Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Toll-like receptor binding GO:0035325 8.62 TLR2 MYD88

Sources for Human Monocytic Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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