MCID: HMN021
MIFTS: 52

Human T-Cell Leukemia Virus Type 1

Categories: Rare diseases, Immune diseases, Cancer diseases, Skin diseases, Blood diseases

Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 1:

Name: Human T-Cell Leukemia Virus Type 1 53
Human T Lymphotropic Virus Type 1 53
Htlv-1 53

Classifications:



Summaries for Human T-Cell Leukemia Virus Type 1

NIH Rare Diseases : 53 Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to t-cell leukemia and htlv-1 associated myelopathy/tropical spastic paraparesis. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CRTC2 (CREB Regulated Transcription Coactivator 2), and among its related pathways/superpathways are GPCR Pathway and HIV Life Cycle. The drugs Zidovudine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and testes, and related phenotypes are Decreased TP53 mRNA expression and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the... more...

Related Diseases for Human T-Cell Leukemia Virus Type 1

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 t-cell leukemia 28.4 CHUK CNTN2 CREB1 CREBBP CRTC2 EP300
2 htlv-1 associated myelopathy/tropical spastic paraparesis 11.4
3 infective dermatitis associated with htlv-1 11.4
4 leukemia 11.3
5 adult t-cell leukemia 10.6
6 lymphoma 10.4
7 human immunodeficiency virus type 1 10.3
8 myelopathy, htlv-1-associated 10.3
9 tropical spastic paraparesis 10.3
10 spastic paraparesis 10.3
11 spasticity 10.3
12 chromosome 16p13.3 deletion syndrome, proximal 10.2 CREB1 CREBBP EP300
13 melanoma of soft tissue 10.2 ATF1 CREB1
14 hepatitis 10.2
15 hepatitis c 10.2
16 rubinstein-taybi syndrome 1 10.2 CREBBP EP300
17 hepatitis c virus 10.1
18 type i 10.1
19 leukemia, chronic lymphocytic 2 9.9
20 leukemia, chronic lymphocytic 9.9
21 retinoblastoma 9.9
22 rheumatoid arthritis 9.9
23 small cell cancer of the lung 9.9
24 lung cancer 9.9
25 immunodeficiency-centromeric instability-facial anomalies syndrome 1 9.9
26 arthritis 9.9
27 t-cell large granular lymphocyte leukemia 9.9
28 gastric lymphoma 9.9
29 graves' disease 9.9
30 uveitis 9.9
31 arthropathy 9.9
32 borna disease 9.9
33 neuronitis 9.9
34 herpes simplex 9.9
35 lymphosarcoma 9.9
36 stomatitis 9.9
37 glioblastoma 9.9
38 large granular lymphocyte leukemia 9.9
39 leukemia, b-cell, chronic 9.9
40 depression 9.9
41 pituitary tumors 9.9
42 endotheliitis 9.9
43 warthin tumor 9.9 CRTC1 CRTC3
44 human t-cell leukemia virus type 2 9.5 CNTN2 CREB1 CREBBP EP300 NFKB1
45 helicobacter pylori infection 9.5 CHUK JUN NFKB1

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:



Diseases related to Human T-Cell Leukemia Virus Type 1

Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 1

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 9.13 CREB1 JUN NFKB1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 NFKB1 BST2 CDKN1A EP300 JUN

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 1:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.14 CHUK CRTC1 CRTC2 CRTC3 CREB1 EP300
2 growth/size/body region MP:0005378 10.13 CDKN1A CREBBP CRTC1 CHUK CRTC3 CREB1
3 endocrine/exocrine gland MP:0005379 10.11 CHUK CRTC1 CREB1 EP300 CDKN1A CREBBP
4 embryo MP:0005380 10.02 CDKN1A CREBBP CHUK CREB1 EP300 GLI2
5 craniofacial MP:0005382 9.97 CDKN1A CREBBP CHUK NFKB1 EP300 GLI2
6 liver/biliary system MP:0005370 9.87 CHUK CRTC2 CRTC3 CDKN1A CREBBP NFKB1
7 limbs/digits/tail MP:0005371 9.85 CREBBP CHUK CNTN2 CRTC3 CDKN1A GLI2
8 nervous system MP:0003631 9.81 CDKN1A CREBBP CHUK CNTN2 CREB1 NFKB1
9 muscle MP:0005369 9.8 CRTC3 CREB1 CDKN1A CREBBP NFKB1 EP300
10 respiratory system MP:0005388 9.56 CHUK CREB1 EP300 CDKN1A CREBBP NFKB1
11 skeleton MP:0005390 9.23 CREBBP CHUK CRTC3 CREB1 CDKN1A NFKB1

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

Drugs for Human T-Cell Leukemia Virus Type 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 4,Phase 2,Phase 3,Early Phase 1 30516-87-1 35370
2
Valproic Acid Approved, Investigational Phase 4,Phase 3,Not Applicable 99-66-1 3121
3
Peginterferon alfa-2b Approved Phase 4,Phase 2 99210-65-8, 215647-85-1
4 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Not Applicable
5 Anticonvulsants Phase 4,Phase 3,Phase 1,Not Applicable
6 interferons Phase 4,Phase 2
7 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
8 Reverse Transcriptase Inhibitors Phase 4,Phase 2,Phase 3,Early Phase 1
9 GABA Agents Phase 4,Phase 3,Not Applicable
10 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Early Phase 1
11 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
12 Immunoglobulin G Phase 4,Phase 1,Phase 2
13 Antibodies Phase 4,Phase 1,Phase 2
14 Immunoglobulins Phase 4,Phase 1,Phase 2
15 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
17 Interferon-alpha Phase 4,Phase 2
18 Anti-HIV Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19 Anti-Retroviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
20 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
21 Antimanic Agents Phase 4,Phase 3,Not Applicable
22 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
23 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
24
Lamivudine Approved, Investigational Phase 2, Phase 3,Phase 3 134678-17-4 60825
25
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
26
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
27
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
28
Lopinavir Approved Phase 2, Phase 3 192725-17-0 92727
29 Raltegravir Potassium Phase 2, Phase 3,Phase 1,Early Phase 1
30 Cyclosporins Phase 2, Phase 3
31 HIV Integrase Inhibitors Phase 2, Phase 3,Phase 1,Early Phase 1
32 Dermatologic Agents Phase 2, Phase 3
33 Vasodilator Agents Phase 3
34 Phosphodiesterase Inhibitors Phase 3
35 Platelet Aggregation Inhibitors Phase 3
36 Integrase Inhibitors Phase 2, Phase 3,Phase 1,Early Phase 1
37 Antifungal Agents Phase 2, Phase 3
38 Antioxidants Phase 3
39 Protective Agents Phase 3
40 Radiation-Protective Agents Phase 3
41 Antirheumatic Agents Phase 2, Phase 3,Phase 1
42 Calcineurin Inhibitors Phase 2, Phase 3
43
protease inhibitors Phase 2, Phase 3
44 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
45 HIV Protease Inhibitors Phase 2, Phase 3
46 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
47
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
48
Lenograstim Approved, Investigational Phase 2 135968-09-1
49
alemtuzumab Approved, Investigational Phase 2,Phase 1 216503-57-0
50
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
2 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
3 Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
4 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
5 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
6 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
7 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
8 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
9 Antiretroviral Regimens Containing Raltegravir for Prophylaxis of Mother-to-child-transmission of HIV Infection Recruiting NCT01854762 Phase 2, Phase 3 Raltegravir;Lopinavir/Ritonavir
10 A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) Active, not recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
11 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
12 Lenalidomide in HTLV-1 Adult T-Cell Leukemia Completed NCT01274533 Phase 2 Lenalidomide
13 Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma Completed NCT00041327 Phase 2 Etoposide;cyclophosphamide;doxorubicin hydrochloride;lamivudine;prednisone;vincristine sulfate;zidovudine
14 Anti-Tac for Treatment of Leukemia Completed NCT00001941 Phase 1, Phase 2
15 EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia Lymphoma Completed NCT01000285 Phase 1, Phase 2 Bortezomib;Etoposide;Vincristine;Doxorubicin;Prednisone;Cyclophosphamide;Raltegravir
16 Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma Completed NCT00061048 Phase 2
17 Phase II Study of the Efficacy and Toxicity of Ontak(Registered Trademark) (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia Completed NCT00117845 Phase 2
18 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
19 Ruxolitinib for Adult T-Cell Leukemia Recruiting NCT01712659 Phase 2 Ruxolitinib
20 Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Recruiting NCT02737046 Phase 2 Belinostat;Zidovudine;Interferon-Alfa-2b;Pegylated Interferon-Alfa-2b
21 Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Recruiting NCT03075553 Phase 2
22 Long-term Safety and Efficacy Follow-up of Subjects Treated With GSK2696277 for Transfusion Dependent Beta-thalassemia in San Raffaele Telethon Institute of Gene Therapy-Beta Thalassemia (TIGET-BTHAL) Study Recruiting NCT03275051 Phase 2
23 Nivolumab in Treating Patients With HTLV-Associated T-Cell Leukemia/Lymphoma Active, not recruiting NCT02631746 Phase 2
24 Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia Active, not recruiting NCT00924170 Phase 1, Phase 2 LMB-2;Fludarabine;Cyclophosphamide
25 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
26 Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load Withdrawn NCT01620736 Phase 2 Raltegravir
27 A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive Bladder Unknown status NCT01640002 Phase 1 Propantheline Bromide;Placebo
28 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
29 A Phase I, Multicenter, Open-label, Dose-escalation Study to Assess the Safety of Lenalidomide in Patients With Advanced Adult T-cell Leukemia-lymphoma and Peripheral T-cell Lymphomaperipheral T-cell Lymphoma Completed NCT01169298 Phase 1 Lenalidomide
30 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Recruiting NCT02961712 Phase 1
31 Subcutaneous Recombinant Human IL-15 (s.c. rhIL-15) and Alemtuzumab for People With Refractory or Relapsed Chronic and Acute Adult T-cell Leukemia (ATL) Recruiting NCT02689453 Phase 1
32 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819 Not Applicable
33 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
34 Notification of Donors With Positive Microbiology Markers Unknown status NCT01050881
35 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
36 Natural History of HTLV-I Infection: Prospective Follow-up of a Cohort of Blood Donors in Jamaica Completed NCT00339807
37 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
38 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
39 Sensorimotor Exercises in Virtual Reality Platform in Individuals With Human T-lymphotropic Virus Completed NCT02877030 Not Applicable
40 Dual Algorithm Post Market Clinical Study Completed NCT03146013
41 Epidemic History and Iatrogenic Transmission of Blood-borne Viruses in Mid-20th Century Kinshasa Completed NCT02439918
42 Study of Adult T-Cell Leukemia/Lymphoma Among Carriers of HTLV-1 Completed NCT00339638
43 Neuroimmunology Branch Repository Completed NCT01581567
44 Retrovirus Epidemiology Donor Study I (REDS I) Completed NCT00005278
45 Idiopathic CD4 Lymphocytopenia Completed NCT02113930
46 Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic Leukemia Completed NCT01520246
47 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
48 Late Effects of Treatment for Sarcomas in Children Completed NCT00006515
49 Improving Blood Safety and HIV Testing in Brazil Completed NCT01681420 Not Applicable
50 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

Genetic Tests for Human T-Cell Leukemia Virus Type 1

Anatomical Context for Human T-Cell Leukemia Virus Type 1

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

41
T Cells, Breast, Testes, Brain, Nk Cells, Liver, Monocytes

Publications for Human T-Cell Leukemia Virus Type 1

Articles related to Human T-Cell Leukemia Virus Type 1:

(show top 50) (show all 457)
# Title Authors Year
1
Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. ( 29930027 )
2018
2
Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor. ( 29212930 )
2018
3
In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1. ( 29499169 )
2018
4
Natural Course of Human T-Cell Leukemia Virus Type 1 Proviral DNA Levels in Carriers During Pregnancy. ( 29346571 )
2018
5
Fine-scale geographic clustering pattern of human T-cell leukemia virus type 1 infection among blood donors in Kyushu-Okinawa, Japan. ( 29900555 )
2018
6
Critical Role of the Human T-Cell Leukemia Virus Type 1 Capsid N-Terminal Domain for Gag-Gag Interactions and Virus Particle Assembly. ( 29695435 )
2018
7
Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line. ( 28615198 )
2017
8
Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. ( 29052136 )
2017
9
Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. ( 29186194 )
2017
10
Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice. ( 28302940 )
2017
11
Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results. ( 28701419 )
2017
12
Failure to prevent human T-cell leukemia virus type 1 mother-to-child transmission in Japan. ( 28211219 )
2017
13
Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging. ( 28753950 )
2017
14
Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis. ( 29144838 )
2017
15
Human T Cell Leukemia Virus Type 1 and Eye Diseases. ( 28263674 )
2017
16
RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells. ( 28478312 )
2017
17
Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1. ( 26792732 )
2016
18
Impact of human T-cell leukemia virus type 1 on living donor liver transplantation: a multi-center study in Japan. ( 26996829 )
2016
19
Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis. ( 26819304 )
2016
20
Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax. ( 26829041 )
2016
21
Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation. ( 26819312 )
2016
22
Expression of Alternatively Spliced Human T-Cell Leukemia Virus Type 1 mRNAs Is Influenced by Mitosis and by a Novel cis-Acting Regulatory Sequence. ( 26581997 )
2016
23
Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex. ( 27697867 )
2016
24
The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1). ( 27776189 )
2016
25
Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB. ( 26739459 )
2016
26
Endemic impact of human T cell leukemia virus type 1 screening in bone allografts. ( 27677902 )
2016
27
Standardization of Quantitative PCR for Human T-Cell Leukemia Virus Type 1 in Japan: a Collaborative Study. ( 26292315 )
2015
28
Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography. ( 25473052 )
2015
29
miR-28-3p is a cellular restriction factor that inhibits human T cell leukemia virus, type 1 (HTLV-1) replication and virus infection. ( 25568327 )
2015
30
Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism. ( 26363219 )
2015
31
Prevalence of human T-cell leukemia virus type 1 carrier in Japanese pregnant women in 2013. ( 25883717 )
2015
32
Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells. ( 25613934 )
2015
33
Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-I_B inhibitor A20 and constitutive NF-I_B signaling. ( 25774694 )
2015
34
Advanced human T-cell leukemia virus type 1 carriersA and early-stage indolent adult T-cell leukemia-lymphoma are indistinguishable based on CADM1 positivity in flow cytometry. ( 25703103 )
2015
35
Viral Source-Independent High Susceptibility of Dendritic Cells to Human T-Cell Leukemia Virus Type 1 Infection Compared to That of T Lymphocytes. ( 26269171 )
2015
36
Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. ( 26198240 )
2015
37
Characterizing the protonation states of the catalytic residues in apo and substrate-bound human T-cell leukemia virus type 1 protease. ( 25889320 )
2015
38
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans. ( 26608313 )
2015
39
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
40
SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription. ( 26063426 )
2015
41
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein. ( 26324707 )
2015
42
Reevaluation of confirmatory tests for human T-cell leukemia virus Type 1 using a luciferase immunoprecipitation system in blood donors. ( 25363675 )
2014
43
Palmitoylation and p8-mediated human T-cell leukemia virus type 1 transmission. ( 24284316 )
2014
44
Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo. ( 24792037 )
2014
45
Small noncoding RNAs in cells transformed by human T-cell leukemia virus type 1: a role for a tRNA fragment as a primer for reverse transcriptase. ( 24403582 )
2014
46
Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis. ( 24352466 )
2014
47
Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats. ( 23622267 )
2013
48
Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1. ( 23606621 )
2013
49
HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-I_B activation and HTLV-1 replication. ( 24109220 )
2013
50
Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1. ( 23888327 )
2013

Variations for Human T-Cell Leukemia Virus Type 1

Expression for Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Pathways for Human T-Cell Leukemia Virus Type 1

Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CDKN1A CHUK CREB1 CREBBP EP300 JUN
2
Show member pathways
13.75 CDKN1A CHUK CREB1 CREBBP EP300 JUN
3
Show member pathways
13.08 CREB1 CREBBP EP300 GLI2 JUN NFKB1
4
Show member pathways
13.05 ATF1 CDKN1A CREB1 CREBBP EP300
5
Show member pathways
13.03 CDKN1A CHUK CREB1 CREBBP CRTC2 EP300
6
Show member pathways
12.96 ATF1 CHUK CREB1 JUN NFKB1
7
Show member pathways
12.93 ATF1 CDKN1A CHUK CREB1 EP300 JUN
8
Show member pathways
12.92 CHUK CREBBP EP300 JUN NFKB1
9
Show member pathways
12.91 CHUK CREB1 CREBBP EP300 JUN NFKB1
10
Show member pathways
12.89 CREB1 CREBBP CRTC1 CRTC2 CRTC3
11
Show member pathways
12.88 CDKN1A CHUK CREB1 CREBBP EP300 JUN
12
Show member pathways
12.85 ATF1 CHUK CREB1 CREBBP JUN NFKB1
13
Show member pathways
12.83 CHUK CREBBP EP300 JUN NFKB1 XPO1
14 12.83 CDKN1A CHUK CREBBP EP300 GLI2 JUN
15
Show member pathways
12.72 CHUK CREB1 CREBBP JUN NFKB1
16
Show member pathways
12.68 BST2 CDKN1A CREBBP EP300
17
Show member pathways
12.66 CDKN1A CHUK CREBBP EP300 NFKB1
18
Show member pathways
12.57 ATF1 CREB1 JUN NFKB1
19 12.56 CDKN1A CREBBP EP300 NFKB1
20
Show member pathways
12.55 CREB1 CREBBP EP300 JUN NFKB1
21
Show member pathways
12.54 CDKN1A CREBBP EP300 JUN NFKB1
22
Show member pathways
12.49 CHUK CREB1 JUN NFKB1
23
Show member pathways
12.49 CHUK CREB1 JUN NFKB1
24
Show member pathways
12.49 CHUK CREB1 CREBBP EP300 JUN NFKB1
25
Show member pathways
12.48 CHUK CREBBP EP300 NFKB1
26
Show member pathways
12.48 CHUK CREBBP EP300 NFKB1
27
Show member pathways
12.48 CHUK CREB1 JUN NFKB1
28
Show member pathways
12.47 CDKN1A CHUK CREB1 CREBBP EP300 JUN
29
Show member pathways
12.46 CHUK CREB1 JUN NFKB1
30
Show member pathways
12.45 CHUK CREB1 JUN NFKB1
31
Show member pathways
12.44 CHUK EP300 JUN NFKB1
32
Show member pathways
12.43 CHUK CREB1 JUN NFKB1
34
Show member pathways
12.37 CREB1 CREBBP EP300 JUN NFKB1
35
Show member pathways
12.34 ATF1 CHUK EP300 JUN NFKB1
36 12.3 CREB1 CREBBP EP300 NFKB1
37 12.3 CDKN1A CREB1 CREBBP EP300 JUN NFKB1
38
Show member pathways
12.29 CDKN1A JUN NFKB1 XPO1
39
Show member pathways
12.28 CHUK CREBBP EP300 JUN NFKB1
40
Show member pathways
12.27 CHUK CREBBP EP300 NFKB1
41 12.24 CREB1 CREBBP EP300 JUN NFKB1
42
Show member pathways
12.2 CDKN1A CHUK EP300 JUN NFKB1
43
Show member pathways
12.19 CREB1 CREBBP CRTC1 CRTC2 CRTC3 EP300
44
Show member pathways
12.18 CHUK CREB1 CREBBP JUN NFKB1
45 12.17 CDKN1A CHUK CREBBP EP300 JUN NFKB1
46
Show member pathways
12.16 CDKN1A CHUK CREBBP EP300
47 12.15 CHUK CREB1 CRTC1 JUN NFKB1
48 12.14 CDKN1A CREBBP EP300 JUN
49 12.13 CDKN1A CREBBP EP300 JUN
50 12.12 CHUK JUN NFKB1

GO Terms for Human T-Cell Leukemia Virus Type 1

Cellular components related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 APOBEC3B ATF1 CDKN1A CHUK CREB1 CREBBP
2 transcription factor complex GO:0005667 9.46 ATF1 CREB1 EP300 JUN
3 nucleoplasm GO:0005654 9.44 ATF1 CDKN1A CHUK CREB1 CREBBP CRTC1
4 cytoplasm GO:0005737 10.03 APOBEC3B BST2 CDKN1A CHUK CREBBP CRTC1

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.97 ATF1 CREB1 EP300 GLI2 JUN NFKB1
2 response to drug GO:0042493 9.88 CDKN1A CHUK CREB1 JUN XPO1
3 regulation of cell cycle GO:0051726 9.8 CDKN1A EP300 JUN
4 response to organic cyclic compound GO:0014070 9.79 ATF1 CDKN1A JUN
5 rhythmic process GO:0048511 9.76 CREB1 CREBBP CRTC1 EP300
6 circadian rhythm GO:0007623 9.75 CREB1 EP300 JUN
7 protein homotetramerization GO:0051289 9.74 CRTC1 CRTC2 CRTC3
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.73 CHUK CREBBP EP300 NFKB1
9 positive regulation of type I interferon production GO:0032481 9.72 CREBBP EP300 NFKB1
10 protein kinase B signaling GO:0043491 9.71 CDKN1A CHUK CREB1
11 positive regulation of DNA replication GO:0045740 9.7 ATF1 GLI2 JUN
12 positive regulation of transcription, DNA-templated GO:0045893 9.7 CHUK CREB1 CREBBP EP300 GLI2 JUN
13 response to organic substance GO:0010033 9.67 CDKN1A CHUK CREB1 JUN
14 positive regulation of transcription of Notch receptor target GO:0007221 9.61 CREBBP EP300
15 positive regulation of long-term synaptic potentiation GO:1900273 9.61 CREB1 CRTC1
16 positive regulation by host of viral transcription GO:0043923 9.6 EP300 JUN
17 response to muscle stretch GO:0035994 9.59 JUN NFKB1
18 protein acetylation GO:0006473 9.58 CREBBP EP300
19 N-terminal peptidyl-lysine acetylation GO:0018076 9.51 CREBBP EP300
20 viral process GO:0016032 9.5 CREB1 CREBBP CRTC1 CRTC2 CRTC3 EP300
21 positive regulation of CREB transcription factor activity GO:0032793 9.43 CRTC1 CRTC2 CRTC3
22 positive regulation of transcription by RNA polymerase II GO:0045944 9.36 ATF1 CHUK CREB1 CREBBP CRTC1 CRTC2
23 regulation of transcription, DNA-templated GO:0006355 10.1 ATF1 CREB1 CREBBP CRTC1 CRTC2 CRTC3
24 negative regulation of transcription by RNA polymerase II GO:0000122 10.03 CREBBP EP300 GLI2 JUN NFKB1 XPO1
25 transcription, DNA-templated GO:0006351 10.02 ATF1 CREB1 CREBBP CRTC1 CRTC2 CRTC3

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.93 ATF1 CREB1 GLI2 JUN NFKB1
2 identical protein binding GO:0042802 9.91 ATF1 BST2 CHUK CNTN2 CREB1 JUN
3 transcription regulatory region DNA binding GO:0044212 9.78 CREB1 GLI2 JUN NFKB1
4 chromatin binding GO:0003682 9.73 CREBBP CRTC2 EP300 GLI2 JUN NFKB1
5 transcription coregulator activity GO:0003712 9.63 CREB1 CREBBP EP300
6 transcription factor binding GO:0008134 9.63 CREB1 CREBBP EP300 GLI2 JUN NFKB1
7 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.61 CREB1 JUN NFKB1
8 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.58 ATF1 CREB1 JUN
9 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.55 CREB1 JUN
10 acetyltransferase activity GO:0016407 9.51 CREBBP EP300
11 cAMP response element binding GO:0035497 9.49 CREB1 JUN
12 peptide N-acetyltransferase activity GO:0034212 9.32 CREBBP EP300
13 RNA polymerase II activating transcription factor binding GO:0001102 9.26 CREB1 CREBBP EP300 JUN
14 cAMP response element binding protein binding GO:0008140 8.8 CRTC1 CRTC2 CRTC3
15 DNA binding transcription factor activity GO:0003700 10 ATF1 CREB1 CREBBP GLI2 JUN NFKB1

Sources for Human T-Cell Leukemia Virus Type 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....