Human T-Cell Leukemia Virus Type 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HMN021 MIFTS: 52	Human T-Cell Leukemia Virus Type 1 Categories: Rare diseases, Immune diseases, Cancer diseases, Skin diseases, Blood diseases
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Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 1:

Name: Human T-Cell Leukemia Virus Type 1 ⁵³

Human T Lymphotropic Virus Type 1 ⁵³

Htlv-1 ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Immune diseases Skin diseases Blood diseases

See all MalaCards categories (disease lists)

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Summaries for Human T-Cell Leukemia Virus Type 1

NIH Rare Diseases : ⁵³ Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to t-cell leukemia and htlv-1 associated myelopathy/tropical spastic paraparesis. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CRTC2 (CREB Regulated Transcription Coactivator 2), and among its related pathways/superpathways are GPCR Pathway and HIV Life Cycle. The drugs Zidovudine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and testes, and related phenotypes are Decreased TP53 mRNA expression and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : ⁷⁶ Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the... more...

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Related Diseases for Human T-Cell Leukemia Virus Type 1

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia	Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1	Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3	Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)

#	Related Disease	Score	Top Affiliating Genes
1	t-cell leukemia	28.4	CHUK CNTN2 CREB1 CREBBP CRTC2 EP300
2	htlv-1 associated myelopathy/tropical spastic paraparesis	11.4
3	infective dermatitis associated with htlv-1	11.4
4	leukemia	11.3
5	adult t-cell leukemia	10.6
6	lymphoma	10.4
7	human immunodeficiency virus type 1	10.3
8	myelopathy, htlv-1-associated	10.3
9	tropical spastic paraparesis	10.3
10	spastic paraparesis	10.3
11	spasticity	10.3
12	chromosome 16p13.3 deletion syndrome, proximal	10.2	CREB1 CREBBP EP300
13	melanoma of soft tissue	10.2	ATF1 CREB1
14	hepatitis	10.2
15	hepatitis c	10.2
16	rubinstein-taybi syndrome 1	10.2	CREBBP EP300
17	hepatitis c virus	10.1
18	type i	10.1
19	leukemia, chronic lymphocytic 2	9.9
20	leukemia, chronic lymphocytic	9.9
21	retinoblastoma	9.9
22	rheumatoid arthritis	9.9
23	small cell cancer of the lung	9.9
24	lung cancer	9.9
25	immunodeficiency-centromeric instability-facial anomalies syndrome 1	9.9
26	arthritis	9.9
27	t-cell large granular lymphocyte leukemia	9.9
28	gastric lymphoma	9.9
29	graves' disease	9.9
30	uveitis	9.9
31	arthropathy	9.9
32	borna disease	9.9
33	neuronitis	9.9
34	herpes simplex	9.9
35	lymphosarcoma	9.9
36	stomatitis	9.9
37	glioblastoma	9.9
38	large granular lymphocyte leukemia	9.9
39	leukemia, b-cell, chronic	9.9
40	depression	9.9
41	pituitary tumors	9.9
42	endotheliitis	9.9
43	warthin tumor	9.9	CRTC1 CRTC3
44	human t-cell leukemia virus type 2	9.5	CNTN2 CREB1 CREBBP EP300 NFKB1
45	helicobacter pylori infection	9.5	CHUK JUN NFKB1

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:

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Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 1

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased TP53 mRNA expression	GR00389-S-5	9.13	CREB1 JUN NFKB1
2	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.02	NFKB1 BST2 CDKN1A EP300 JUN

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 1:

⁴⁶ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.14	CHUK CRTC1 CRTC2 CRTC3 CREB1 EP300
2	growth/size/body region	MP:0005378	10.13	CDKN1A CREBBP CRTC1 CHUK CRTC3 CREB1
3	endocrine/exocrine gland	MP:0005379	10.11	CHUK CRTC1 CREB1 EP300 CDKN1A CREBBP
4	embryo	MP:0005380	10.02	CDKN1A CREBBP CHUK CREB1 EP300 GLI2
5	craniofacial	MP:0005382	9.97	CDKN1A CREBBP CHUK NFKB1 EP300 GLI2
6	liver/biliary system	MP:0005370	9.87	CHUK CRTC2 CRTC3 CDKN1A CREBBP NFKB1
7	limbs/digits/tail	MP:0005371	9.85	CREBBP CHUK CNTN2 CRTC3 CDKN1A GLI2
8	nervous system	MP:0003631	9.81	CDKN1A CREBBP CHUK CNTN2 CREB1 NFKB1
9	muscle	MP:0005369	9.8	CRTC3 CREB1 CDKN1A CREBBP NFKB1 EP300
10	respiratory system	MP:0005388	9.56	CHUK CREB1 EP300 CDKN1A CREBBP NFKB1
11	skeleton	MP:0005390	9.23	CREBBP CHUK CRTC3 CREB1 CDKN1A NFKB1

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Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

Drugs for Human T-Cell Leukemia Virus Type 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Zidovudine

Approved

Phase 4,Phase 2,Phase 3,Early Phase 1

30516-87-1

35370

Valproic Acid

Approved, Investigational

Phase 4,Phase 3,Not Applicable

99-66-1

3121

Peginterferon alfa-2b

Approved

Phase 4,Phase 2

99210-65-8, 215647-85-1

Neurotransmitter Agents

Phase 4,Phase 3,Phase 1,Not Applicable

Anticonvulsants

Phase 4,Phase 3,Phase 1,Not Applicable

interferons

Phase 4,Phase 2

Central Nervous System Depressants

Phase 4,Phase 3,Not Applicable

Reverse Transcriptase Inhibitors

Phase 4,Phase 2,Phase 3,Early Phase 1

GABA Agents

Phase 4,Phase 3,Not Applicable

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 2,Phase 3,Early Phase 1

Tranquilizing Agents

Phase 4,Phase 3,Not Applicable

Immunoglobulin G

Phase 4,Phase 1,Phase 2

Antibodies

Phase 4,Phase 1,Phase 2

Immunoglobulins

Phase 4,Phase 1,Phase 2

Immunosuppressive Agents

Phase 4,Phase 2,Phase 3,Phase 1

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Interferon-alpha

Phase 4,Phase 2

Anti-HIV Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Anti-Retroviral Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Psychotropic Drugs

Phase 4,Phase 3,Not Applicable

Antimanic Agents

Phase 4,Phase 3,Not Applicable

Antimetabolites

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Antiviral Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Lamivudine

Approved, Investigational

Phase 2, Phase 3,Phase 3

134678-17-4

60825

Miconazole

Approved, Investigational, Vet_approved

Phase 2, Phase 3

22916-47-8

4189

Pentoxifylline

Approved, Investigational

Phase 3

6493-05-6

4740

Ritonavir

Approved, Investigational

Phase 2, Phase 3

155213-67-5

392622

Lopinavir

Approved

Phase 2, Phase 3

192725-17-0

92727

Raltegravir Potassium

Phase 2, Phase 3,Phase 1,Early Phase 1

Cyclosporins

Phase 2, Phase 3

HIV Integrase Inhibitors

Phase 2, Phase 3,Phase 1,Early Phase 1

Dermatologic Agents

Phase 2, Phase 3

Vasodilator Agents

Phase 3

Phosphodiesterase Inhibitors

Phase 3

Platelet Aggregation Inhibitors

Phase 3

Integrase Inhibitors

Phase 2, Phase 3,Phase 1,Early Phase 1

Antifungal Agents

Phase 2, Phase 3

Antioxidants

Phase 3

Protective Agents

Phase 3

Radiation-Protective Agents

Phase 3

Antirheumatic Agents

Phase 2, Phase 3,Phase 1

Calcineurin Inhibitors

Phase 2, Phase 3

protease inhibitors

Phase 2, Phase 3

Cytochrome P-450 CYP3A Inhibitors

Phase 2, Phase 3

HIV Protease Inhibitors

Phase 2, Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 2, Phase 3

Gemcitabine

Approved

Phase 1, Phase 2

95058-81-4

60750

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

alemtuzumab

Approved, Investigational

Phase 2,Phase 1

216503-57-0

Etoposide

Approved

Phase 2,Phase 1

33419-42-0

36462

Interventional clinical trials:

(show top 50) (show all 59)

#	Name	Status	NCT ID	Phase	Drugs
1	Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab)	Completed	NCT01418430	Phase 4	CHOP-daclizumab
2	MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study	Active, not recruiting	NCT03226119	Phase 4
3	Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma	Terminated	NCT00854581	Phase 4	Valproic Acid;Zidovudine
4	Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)	Unknown status	NCT01343355	Phase 2, Phase 3	Tamibarotene
5	Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial	Completed	NCT00272480	Phase 2, Phase 3	Zidovudine/lamivudine
6	Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases	Completed	NCT01472263	Phase 3	Pentoxifylline;Placebo
7	Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)	Completed	NCT00773292	Phase 2, Phase 3	ciclosporin
8	Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)	Completed	NCT00681980	Phase 3	Valproic acid;costicosteroids;valproid acid plus corticosteroids
9	Antiretroviral Regimens Containing Raltegravir for Prophylaxis of Mother-to-child-transmission of HIV Infection	Recruiting	NCT01854762	Phase 2, Phase 3	Raltegravir;Lopinavir/Ritonavir
10	A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM)	Active, not recruiting	NCT03191526	Phase 3	KW-0761 0.3 mg/kg IV;Placebo (saline)
11	Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)	Completed	NCT00001785	Phase 2	Recombinant human interferon beta-1a
12	Lenalidomide in HTLV-1 Adult T-Cell Leukemia	Completed	NCT01274533	Phase 2	Lenalidomide
13	Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma	Completed	NCT00041327	Phase 2	Etoposide;cyclophosphamide;doxorubicin hydrochloride;lamivudine;prednisone;vincristine sulfate;zidovudine
14	Anti-Tac for Treatment of Leukemia	Completed	NCT00001941	Phase 1, Phase 2
15	EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia Lymphoma	Completed	NCT01000285	Phase 1, Phase 2	Bortezomib;Etoposide;Vincristine;Doxorubicin;Prednisone;Cyclophosphamide;Raltegravir
16	Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma	Completed	NCT00061048	Phase 2
17	Phase II Study of the Efficacy and Toxicity of Ontak(Registered Trademark) (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia	Completed	NCT00117845	Phase 2
18	Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies	Completed	NCT00481871	Phase 1, Phase 2	Pralatrexate Injection;Gemcitabine Hydrochloride
19	Ruxolitinib for Adult T-Cell Leukemia	Recruiting	NCT01712659	Phase 2	Ruxolitinib
20	Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma	Recruiting	NCT02737046	Phase 2	Belinostat;Zidovudine;Interferon-Alfa-2b;Pegylated Interferon-Alfa-2b
21	Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma	Recruiting	NCT03075553	Phase 2
22	Long-term Safety and Efficacy Follow-up of Subjects Treated With GSK2696277 for Transfusion Dependent Beta-thalassemia in San Raffaele Telethon Institute of Gene Therapy-Beta Thalassemia (TIGET-BTHAL) Study	Recruiting	NCT03275051	Phase 2
23	Nivolumab in Treating Patients With HTLV-Associated T-Cell Leukemia/Lymphoma	Active, not recruiting	NCT02631746	Phase 2
24	Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia	Active, not recruiting	NCT00924170	Phase 1, Phase 2	LMB-2;Fludarabine;Cyclophosphamide
25	The HAM Infliximab Study	Terminated	NCT00823641	Phase 2	Infliximab
26	Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load	Withdrawn	NCT01620736	Phase 2	Raltegravir
27	A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive Bladder	Unknown status	NCT01640002	Phase 1	Propantheline Bromide;Placebo
28	Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis	Completed	NCT00076843	Phase 1	Hu MiK-Beta-1
29	A Phase I, Multicenter, Open-label, Dose-escalation Study to Assess the Safety of Lenalidomide in Patients With Advanced Adult T-cell Leukemia-lymphoma and Peripheral T-cell Lymphomaperipheral T-cell Lymphoma	Completed	NCT01169298	Phase 1	Lenalidomide
30	Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM)	Recruiting	NCT02961712	Phase 1
31	Subcutaneous Recombinant Human IL-15 (s.c. rhIL-15) and Alemtuzumab for People With Refractory or Relapsed Chronic and Acute Adult T-cell Leukemia (ATL)	Recruiting	NCT02689453	Phase 1
32	Urological Physical Therapy in HTLV-1 With Urinary Symptoms	Unknown status	NCT01651819	Not Applicable
33	Evaluation of the MP Diagnostics HTLV Blot 2.4	Unknown status	NCT01467024
34	Notification of Donors With Positive Microbiology Markers	Unknown status	NCT01050881
35	Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1	Completed	NCT01754311
36	Natural History of HTLV-I Infection: Prospective Follow-up of a Cohort of Blood Donors in Jamaica	Completed	NCT00339807
37	A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis	Completed	NCT00340821
38	MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis	Completed	NCT00034723
39	Sensorimotor Exercises in Virtual Reality Platform in Individuals With Human T-lymphotropic Virus	Completed	NCT02877030	Not Applicable
40	Dual Algorithm Post Market Clinical Study	Completed	NCT03146013
41	Epidemic History and Iatrogenic Transmission of Blood-borne Viruses in Mid-20th Century Kinshasa	Completed	NCT02439918
42	Study of Adult T-Cell Leukemia/Lymphoma Among Carriers of HTLV-1	Completed	NCT00339638
43	Neuroimmunology Branch Repository	Completed	NCT01581567
44	Retrovirus Epidemiology Donor Study I (REDS I)	Completed	NCT00005278
45	Idiopathic CD4 Lymphocytopenia	Completed	NCT02113930
46	Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic Leukemia	Completed	NCT01520246
47	Assessment of Patients With Multiple Sclerosis (MS)	Completed	NCT00001156
48	Late Effects of Treatment for Sarcomas in Children	Completed	NCT00006515
49	Improving Blood Safety and HIV Testing in Brazil	Completed	NCT01681420	Not Applicable
50	Retrovirus Epidemiology Donor Study-II (REDS-II)	Completed	NCT00097006

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

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Genetic Tests for Human T-Cell Leukemia Virus Type 1

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Anatomical Context for Human T-Cell Leukemia Virus Type 1

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

⁴¹

T Cells, Breast, Testes, Brain, Nk Cells, Liver, Monocytes

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Publications for Human T-Cell Leukemia Virus Type 1

Articles related to Human T-Cell Leukemia Virus Type 1:

(show top 50) (show all 457)

#	Title	Authors	Year
1	Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan. ( 29930027 )	Fukumoto T....Iha H.	2018
2	Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor. ( 29212930 )	Tezuka K....Hamaguchi I.	2018
3	In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1. ( 29499169 )	Assone T....Casseb J.	2018
4	Natural Course of Human T-Cell Leukemia Virus Type 1 Proviral DNA Levels in Carriers During Pregnancy. ( 29346571 )	Fuchi N....Masuzaki H.	2018
5	Fine-scale geographic clustering pattern of human T-cell leukemia virus type 1 infection among blood donors in Kyushu-Okinawa, Japan. ( 29900555 )	Sagara Y....Irita K.	2018
6	Critical Role of the Human T-Cell Leukemia Virus Type 1 Capsid N-Terminal Domain for Gag-Gag Interactions and Virus Particle Assembly. ( 29695435 )	Martin J.L....Mansky L.M.	2018
7	Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line. ( 28615198 )	Meissner M.E....Mansky L.M.	2017
8	Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. ( 29052136 )	Chan C.P....Jin D.Y.	2017
9	Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. ( 29186194 )	Furuta R....Matsuoka M.	2017
10	Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice. ( 28302940 )	Ohsugi T.	2017
11	Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results. ( 28701419 )	Kuramitsu M....Hamaguchi I.	2017
12	Failure to prevent human T-cell leukemia virus type 1 mother-to-child transmission in Japan. ( 28211219 )	Nerome Y....Kawano Y.	2017
13	Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging. ( 28753950 )	Maldonado J.O....Mansky L.M.	2017
14	Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis. ( 29144838 )	Bangham C.R.M.	2017
15	Human T Cell Leukemia Virus Type 1 and Eye Diseases. ( 28263674 )	Terada Y....Mochizuki M.	2017
16	RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells. ( 28478312 )	Lin H.C....Rabson A.B.	2017
17	Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1. ( 26792732 )	Laverdure S....Lemasson I.	2016
18	Impact of human T-cell leukemia virus type 1 on living donor liver transplantation: a multi-center study in Japan. ( 26996829 )	Yoshizumi T....Maehara Y.	2016
19	Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis. ( 26819304 )	Panfil A.R....Green P.L.	2016
20	Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax. ( 26829041 )	Mizuguchi M....Nakamura M.	2016
21	Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation. ( 26819312 )	Yuen C.K....Kok K.H.	2016
22	Expression of Alternatively Spliced Human T-Cell Leukemia Virus Type 1 mRNAs Is Influenced by Mitosis and by a Novel cis-Acting Regulatory Sequence. ( 26581997 )	Cavallari I....Ciminale V.	2016
23	Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex. ( 27697867 )	Mukai R....Ohshima T.	2016
24	The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1). ( 27776189 )	Gross C....Thoma-Kress A.K.	2016
25	Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB. ( 26739459 )	Motai Y....Fujii M.	2016
26	Endemic impact of human T cell leukemia virus type 1 screening in bone allografts. ( 27677902 )	Ishidou Y....Komiya S.	2016
27	Standardization of Quantitative PCR for Human T-Cell Leukemia Virus Type 1 in Japan: a Collaborative Study. ( 26292315 )	Kuramitsu M....Hamaguchi I.	2015
28	Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography. ( 25473052 )	Cao S....Zhang W.	2015
29	miR-28-3p is a cellular restriction factor that inhibits human T cell leukemia virus, type 1 (HTLV-1) replication and virus infection. ( 25568327 )	Bai X.T....Nicot C.	2015
30	Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism. ( 26363219 )	Mohr C.F....Thoma-Kress A.K.	2015
31	Prevalence of human T-cell leukemia virus type 1 carrier in Japanese pregnant women in 2013. ( 25883717 )	Suzuki S....Kinoshita K.	2015
32	Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells. ( 25613934 )	Takachi T....Fujii M.	2015
33	Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-I_B inhibitor A20 and constitutive NF-I_B signaling. ( 25774694 )	Pujari R....Shembade N.	2015
34	Advanced human T-cell leukemia virus type 1 carriersA and early-stage indolent adult T-cell leukemia-lymphoma are indistinguishable based on CADM1 positivity in flow cytometry. ( 25703103 )	Kobayashi S....Uchimaru K.	2015
35	Viral Source-Independent High Susceptibility of Dendritic Cells to Human T-Cell Leukemia Virus Type 1 Infection Compared to That of T Lymphocytes. ( 26269171 )	Alais S....Dutartre H.	2015
36	Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. ( 26198240 )	Carpentier A....Willems L.	2015
37	Characterizing the protonation states of the catalytic residues in apo and substrate-bound human T-cell leukemia virus type 1 protease. ( 25889320 )	Ma S....Ruhoff A.J.	2015
38	Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans. ( 26608313 )	de Castro-Amarante M.F....Franchini G.	2015
39	Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )	Boostani R....Rezaee S.A.	2015
40	SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription. ( 26063426 )	Tang H.M....Jin D.Y.	2015
41	Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein. ( 26324707 )	Cherian M.A....Ratner L.	2015
42	Reevaluation of confirmatory tests for human T-cell leukemia virus Type 1 using a luciferase immunoprecipitation system in blood donors. ( 25363675 )	Furuta R.A....Hirayama F.	2014
43	Palmitoylation and p8-mediated human T-cell leukemia virus type 1 transmission. ( 24284316 )	Edwards D....Franchini G.	2014
44	Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo. ( 24792037 )	Miyazato P....Matsuoka M.	2014
45	Small noncoding RNAs in cells transformed by human T-cell leukemia virus type 1: a role for a tRNA fragment as a primer for reverse transcriptase. ( 24403582 )	Ruggero K....D'Agostino D.M.	2014
46	Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis. ( 24352466 )	Wang W....Zheng D.	2014
47	Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats. ( 23622267 )	Chan C.P....Jin D.Y.	2013
48	Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1. ( 23606621 )	Satou Y....Matsuoka M.	2013
49	HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-I_B activation and HTLV-1 replication. ( 24109220 )	Gao L....Harhaj E.W.	2013
50	Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1. ( 23888327 )	Manuel S.L....Jain P.	2013

Sources

Genes for Human T-Cell Leukemia Virus Type 1

Genes related to Human T-Cell Leukemia Virus Type 1 (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	26.81	GeneCards inferred via : Publications Proteins Functions (show sections)
2	CNTN2	Contactin 2	Protein Coding	19.38	GeneCards inferred via : Publications (show sections)
3	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	18.98	GeneCards inferred via : Publications (show sections)
4	EP300	E1A Binding Protein P300	Protein Coding	18.41	GeneCards inferred via : Publications (show sections)
5	CREBBP	CREB Binding Protein	Protein Coding	18.41	GeneCards inferred via : Publications (show sections)
6	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	18.3	GeneCards inferred via : Publications (show sections)
7	GLI2	GLI Family Zinc Finger 2	Protein Coding	18.3	GeneCards inferred via : Publications (show sections)
8	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	18.16	GeneCards inferred via : Publications (show sections)
9	XPO1	Exportin 1	Protein Coding	18.16	GeneCards inferred via : Publications (show sections)
10	ATF1	Activating Transcription Factor 1	Protein Coding	18.07	GeneCards inferred via : Publications (show sections)
11	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	18.07	GeneCards inferred via : Publications (show sections)
12	APOBEC3B	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B	Protein Coding	17.99	GeneCards inferred via : Functions (show sections)
13	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	17.99	GeneCards inferred via : Functions (show sections)
14	CHUK	Conserved Helix-Loop-Helix Ubiquitous Kinase	Protein Coding	17.96	GeneCards inferred via : Publications (show sections)
15	CRTC3	CREB Regulated Transcription Coactivator 3	Protein Coding	17.02	GeneCards inferred via : Publications Functions (show sections)
16	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	16.77	GeneCards inferred via : Publications Functions (show sections)

Sources

Variations for Human T-Cell Leukemia Virus Type 1

Sources

Expression for Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Sources

Pathways for Human T-Cell Leukemia Virus Type 1

Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 125)

#	Super pathways	Score	Top Affiliating Genes
1	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.76	CDKN1A CHUK CREB1 CREBBP EP300 JUN
2	HIV Life Cycle ⁶⁶ Show member pathways 2-LTR circle formation ⁶⁶ APOBEC3G mediated resistance to HIV-1 infection ⁶⁶ Assembly Of The HIV Virion ⁶⁶ Binding and entry of HIV virion ⁶⁶ Disease ⁶⁶ Diseases of signal transduction ⁶⁶ Early Phase of HIV Life Cycle ⁶⁶ HIV Infection ⁶⁶ Host Interactions of HIV factors ⁶⁶ Infectious disease ⁶⁶ Integration of provirus ⁶⁶ Late Phase of HIV Life Cycle ⁶⁶	13.75	CDKN1A CHUK CREB1 CREBBP EP300 JUN
3	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴ Hedgehog Signaling in Mammals ⁶⁴ Relaxin Pathway ⁶⁴ Signaling in Gap Junctions ⁶⁴	13.08	CREB1 CREBBP EP300 GLI2 JUN NFKB1
4	Aldosterone synthesis and secretion ³⁷ Show member pathways Adrenergic signaling in cardiomyocytes ³⁷ Ca2+ activated K+ channels ⁶⁶ Cortisol synthesis and secretion ³⁷ Cushing's syndrome ³⁷ Insulin secretion ³⁷ Melanogenesis ³⁷ Thyroid hormone synthesis ³⁷	13.05	ATF1 CDKN1A CREB1 CREBBP EP300
5	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	13.03	CDKN1A CHUK CREB1 CREBBP CRTC2 EP300
6	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.96	ATF1 CHUK CREB1 JUN NFKB1
7	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathway ¹ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-4 signaling pathway ²² Immune response IL-9 signaling pathway ²²	12.93	ATF1 CDKN1A CHUK CREB1 EP300 JUN
8	CCR5 Pathway in Macrophages ⁶⁴ Show member pathways Androgen Signaling ⁶⁴ Chemokine Signaling ⁶⁴ Chemokine signaling pathway ³⁷	12.92	CHUK CREBBP EP300 JUN NFKB1
9	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.91	CHUK CREB1 CREBBP EP300 JUN NFKB1
10	Organelle biogenesis and maintenance ⁶⁶ Show member pathways Cilium Assembly ⁶⁶	12.89	CREB1 CREBBP CRTC1 CRTC2 CRTC3
11	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.88	CDKN1A CHUK CREB1 CREBBP EP300 JUN
12	IL-2 Pathway ⁶⁴ Show member pathways HMGB1 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TREM1 Pathway ⁶⁴	12.85	ATF1 CHUK CREB1 CREBBP JUN NFKB1
13	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.83	CHUK CREBBP EP300 JUN NFKB1 XPO1
14	Pathways in cancer ³⁷	12.83	CDKN1A CHUK CREBBP EP300 GLI2 JUN
15	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.72	CHUK CREB1 CREBBP JUN NFKB1
16	Regulation of IFNA signaling ⁶⁶ Show member pathways Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Jak-STAT signaling pathway ³⁷	12.68	BST2 CDKN1A CREBBP EP300
17	Notch signaling pathway (KEGG) ¹ Show member pathways Notch Signaling ⁶⁴ Notch signaling pathway ³⁷ Notch Signaling Pathway ¹ Notch Signaling Pathway ¹ Notch Signaling Pathways ⁶⁵	12.66	CDKN1A CHUK CREBBP EP300 NFKB1
18	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.57	ATF1 CREB1 JUN NFKB1
19	MicroRNAs in cancer ³⁷	12.56	CDKN1A CREBBP EP300 NFKB1
20	BMP Pathway ⁶⁴ Show member pathways Caspase Cascade ⁶⁴ Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels ⁶⁶ DREAM Repression and Dynorphin Expression ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ TOB in Osteoblast Signaling ⁶⁴	12.55	CREB1 CREBBP EP300 JUN NFKB1
21	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.54	CDKN1A CREBBP EP300 JUN NFKB1
22	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.49	CHUK CREB1 JUN NFKB1
23	CNTF Signaling ⁶⁴ Show member pathways BDNF Pathway ⁶⁴ FLT3 Signaling ⁶⁴ IL-3 Pathway ⁶⁴ Nur77-Induced AICD in Macrophage ⁶⁴ OSM Pathway ⁶⁴	12.49	CHUK CREB1 JUN NFKB1
24	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.49	CHUK CREB1 CREBBP EP300 JUN NFKB1
25	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.48	CHUK CREBBP EP300 NFKB1
26	Cytosolic sensors of pathogen-associated DNA ⁶⁶ Show member pathways DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁶ IkBA variant leads to EDA-ID ⁶⁶ IKBKB deficiency causes SCID ⁶⁶ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁶ IRF3 mediated activation of type 1 IFN ⁶⁶ IRF3-mediated induction of type I IFN ⁶⁶ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁶ Regulation by TREX1 ⁶⁶ Regulation of innate immune responses to cytosolic DNA ⁶⁶ RIP-mediated NFkB activation via ZBP1 ⁶⁶ STAT6-mediated induction of chemokines ⁶⁶ STING mediated induction of host immune responses ⁶⁶ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁶ TRAF6 mediated NF-kB activation ⁶⁶ ZBP1(DAI) mediated induction of type I IFNs ⁶⁶	12.48	CHUK CREBBP EP300 NFKB1
27	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.48	CHUK CREB1 JUN NFKB1
28	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.47	CDKN1A CHUK CREB1 CREBBP EP300 JUN
29	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.46	CHUK CREB1 JUN NFKB1
30	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.45	CHUK CREB1 JUN NFKB1
31	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.44	CHUK EP300 JUN NFKB1
32	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.43	CHUK CREB1 JUN NFKB1
33	Circadian rythm related genes ¹	12.37	CREB1 CRTC1 EP300 JUN
34	cAMP signaling pathway ³⁷ Show member pathways Hydroxycarboxylic acid-binding receptors ⁶⁶	12.37	CREB1 CREBBP EP300 JUN NFKB1
35	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.34	ATF1 CHUK EP300 JUN NFKB1
36	Tuberculosis ³⁷	12.3	CREB1 CREBBP EP300 NFKB1
37	Viral carcinogenesis ³⁷	12.3	CDKN1A CREB1 CREBBP EP300 JUN NFKB1
38	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	12.29	CDKN1A JUN NFKB1 XPO1
39	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.28	CHUK CREBBP EP300 JUN NFKB1
40	Development NOTCH1-mediated pathway for NF-KB activity modulation ²² Show member pathways Development Notch Signaling Pathway ²² Transcription Sin3 and NuRD in transcription regulation ²²	12.27	CHUK CREBBP EP300 NFKB1
41	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.24	CREB1 CREBBP EP300 JUN NFKB1
42	Immune response Function of MEF2 in T lymphocytes ²² Show member pathways Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis ²²	12.2	CDKN1A CHUK EP300 JUN NFKB1
43	BMAL1-CLOCK,NPAS2 activates circadian gene expression ⁶⁶ Show member pathways Circadian Clock ⁶⁶ NR1D1 (REV-ERBA) represses gene expression ⁶⁶ RORA activates gene expression ⁶⁶ YAP1- and WWTR1 (TAZ)-stimulated gene expression ⁶⁶	12.19	CREB1 CREBBP CRTC1 CRTC2 CRTC3 EP300
44	NGF Pathway ⁶⁴ Show member pathways TRKA Signaling ⁶⁴	12.18	CHUK CREB1 CREBBP JUN NFKB1
45	Epstein-Barr virus infection ³⁷	12.17	CDKN1A CHUK CREBBP EP300 JUN NFKB1
46	FoxO signaling pathway ³⁷ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	12.16	CDKN1A CHUK CREBBP EP300
47	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	12.15	CHUK CREB1 CRTC1 JUN NFKB1
48	TGF-beta Signaling Pathway (WikiPathways) ¹	12.14	CDKN1A CREBBP EP300 JUN
49	Direct p53 effectors ¹	12.13	CDKN1A CREBBP EP300 JUN
50	Fluid shear stress and atherosclerosis ³⁷	12.12	CHUK JUN NFKB1

Sources

GO Terms for Human T-Cell Leukemia Virus Type 1

Cellular components related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.8	APOBEC3B ATF1 CDKN1A CHUK CREB1 CREBBP
2	transcription factor complex	GO:0005667	9.46	ATF1 CREB1 EP300 JUN
3	nucleoplasm	GO:0005654	9.44	ATF1 CDKN1A CHUK CREB1 CREBBP CRTC1
4	cytoplasm	GO:0005737	10.03	APOBEC3B BST2 CDKN1A CHUK CREBBP CRTC1

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 25)

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription by RNA polymerase II	GO:0006366	9.97	ATF1 CREB1 EP300 GLI2 JUN NFKB1
2	response to drug	GO:0042493	9.88	CDKN1A CHUK CREB1 JUN XPO1
3	regulation of cell cycle	GO:0051726	9.8	CDKN1A EP300 JUN
4	response to organic cyclic compound	GO:0014070	9.79	ATF1 CDKN1A JUN
5	rhythmic process	GO:0048511	9.76	CREB1 CREBBP CRTC1 EP300
6	circadian rhythm	GO:0007623	9.75	CREB1 EP300 JUN
7	protein homotetramerization	GO:0051289	9.74	CRTC1 CRTC2 CRTC3
8	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.73	CHUK CREBBP EP300 NFKB1
9	positive regulation of type I interferon production	GO:0032481	9.72	CREBBP EP300 NFKB1
10	protein kinase B signaling	GO:0043491	9.71	CDKN1A CHUK CREB1
11	positive regulation of DNA replication	GO:0045740	9.7	ATF1 GLI2 JUN
12	positive regulation of transcription, DNA-templated	GO:0045893	9.7	CHUK CREB1 CREBBP EP300 GLI2 JUN
13	response to organic substance	GO:0010033	9.67	CDKN1A CHUK CREB1 JUN
14	positive regulation of transcription of Notch receptor target	GO:0007221	9.61	CREBBP EP300
15	positive regulation of long-term synaptic potentiation	GO:1900273	9.61	CREB1 CRTC1
16	positive regulation by host of viral transcription	GO:0043923	9.6	EP300 JUN
17	response to muscle stretch	GO:0035994	9.59	JUN NFKB1
18	protein acetylation	GO:0006473	9.58	CREBBP EP300
19	N-terminal peptidyl-lysine acetylation	GO:0018076	9.51	CREBBP EP300
20	viral process	GO:0016032	9.5	CREB1 CREBBP CRTC1 CRTC2 CRTC3 EP300
21	positive regulation of CREB transcription factor activity	GO:0032793	9.43	CRTC1 CRTC2 CRTC3
22	positive regulation of transcription by RNA polymerase II	GO:0045944	9.36	ATF1 CHUK CREB1 CREBBP CRTC1 CRTC2
23	regulation of transcription, DNA-templated	GO:0006355	10.1	ATF1 CREB1 CREBBP CRTC1 CRTC2 CRTC3
24	negative regulation of transcription by RNA polymerase II	GO:0000122	10.03	CREBBP EP300 GLI2 JUN NFKB1 XPO1
25	transcription, DNA-templated	GO:0006351	10.02	ATF1 CREB1 CREBBP CRTC1 CRTC2 CRTC3

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.93	ATF1 CREB1 GLI2 JUN NFKB1
2	identical protein binding	GO:0042802	9.91	ATF1 BST2 CHUK CNTN2 CREB1 JUN
3	transcription regulatory region DNA binding	GO:0044212	9.78	CREB1 GLI2 JUN NFKB1
4	chromatin binding	GO:0003682	9.73	CREBBP CRTC2 EP300 GLI2 JUN NFKB1
5	transcription coregulator activity	GO:0003712	9.63	CREB1 CREBBP EP300
6	transcription factor binding	GO:0008134	9.63	CREB1 CREBBP EP300 GLI2 JUN NFKB1
7	RNA polymerase II distal enhancer sequence-specific DNA binding	GO:0000980	9.61	CREB1 JUN NFKB1
8	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0003705	9.58	ATF1 CREB1 JUN
9	transcriptional activator activity, RNA polymerase II transcription factor binding	GO:0001190	9.55	CREB1 JUN
10	acetyltransferase activity	GO:0016407	9.51	CREBBP EP300
11	cAMP response element binding	GO:0035497	9.49	CREB1 JUN
12	peptide N-acetyltransferase activity	GO:0034212	9.32	CREBBP EP300
13	RNA polymerase II activating transcription factor binding	GO:0001102	9.26	CREB1 CREBBP EP300 JUN
14	cAMP response element binding protein binding	GO:0008140	8.8	CRTC1 CRTC2 CRTC3
15	DNA binding transcription factor activity	GO:0003700	10	ATF1 CREB1 CREBBP GLI2 JUN NFKB1

Sources

Sources for Human T-Cell Leukemia Virus Type 1

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia