Human T-Cell Leukemia Virus Type 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HMN021 MIFTS: 38	Human T-Cell Leukemia Virus Type 1 Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 1:

Name: Human T-Cell Leukemia Virus Type 1 ¹⁹

Human T Lymphotropic Virus Type 1 ¹⁹

Htlv-1 ¹⁹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Immune diseases Bone diseases Blood diseases

See all MalaCards categories (disease lists)

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Summaries for Human T-Cell Leukemia Virus Type 1

GARD: ¹⁹ Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It may be passed from mother to child during birth or breast-feeding.

MalaCards based summary: Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to adult t-cell leukemia/lymphoma and tropical spastic paraparesis. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CRTC2 (CREB Regulated Transcription Coactivator 2), and among its related pathways/superpathways are Cellular responses to stimuli and Organelle biogenesis and maintenance. The drugs Pentoxifylline and Mogamulizumab have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone marrow, and related phenotype is Increased hepcidin::fluc mRNA expression.

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Related Diseases for Human T-Cell Leukemia Virus Type 1

Diseases in the Leukemia, T-Cell, Chronic family:

Human T-Cell Leukemia Virus Type 1	Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 571)

#	Related Disease	Score
1	adult t-cell leukemia/lymphoma	11.7
2	tropical spastic paraparesis	11.7
3	t-cell acute lymphoblastic leukemia	11.6
4	leukemia, t-cell, chronic	11.6
5	infective dermatitis associated with htlv-1	11.6
6	leukemia	11.4
7	spinal cord disease	11.2
8	hereditary spastic paraplegia	11.1
9	spastic paraparesis	11.1
10	pars planitis	11.1
11	intermediate uveitis	11.1
12	t-cell prolymphocytic leukemia	11.1
13	human immunodeficiency virus type 1	10.9
14	human t-cell leukemia virus type 2	10.9
15	t-cell adult acute lymphocytic leukemia	10.9
16	lymphoma	10.7
17	immune deficiency disease	10.6
18	burkitt lymphoma	10.6
19	adult syndrome	10.6
20	uveitis	10.6
21	chronic bilirubin encephalopathy	10.6
22	rheumatoid arthritis	10.6
23	down syndrome	10.6
24	severe combined immunodeficiency	10.6
25	stomatitis	10.6
26	dermatitis	10.5
27	hepatitis c virus	10.5
28	lymphoproliferative syndrome	10.5
29	hepatitis c	10.5
30	viral infectious disease	10.5
31	leukemia, chronic lymphocytic	10.5
32	retinoblastoma	10.5
33	acquired immunodeficiency syndrome	10.5
34	b-cell lymphoma	10.5
35	arthritis	10.5
36	primary agammaglobulinemia	10.5
37	fungal infectious disease	10.4
38	polymyositis	10.4
39	mycosis fungoides	10.4
40	myopathy	10.4
41	adrenocortical carcinoma, hereditary	10.4
42	lymphoma, hodgkin, classic	10.4
43	osteogenic sarcoma	10.4
44	sjogren syndrome	10.4
45	leukemia, acute lymphoblastic	10.4
46	helix syndrome	10.4
47	reading disorder	10.4
48	hematologic cancer	10.4
49	vaccinia	10.4
50	cytokine deficiency	10.4

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:

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Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 1

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased hepcidin::fluc mRNA expression	GR00253-A	8.32	CRTC3

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Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

Drugs for Human T-Cell Leukemia Virus Type 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Pentoxifylline

Approved, Investigational

Phase 3

6493-05-6

4740

Mogamulizumab

Approved, Investigational

Phase 3

1159266-37-1

Radiation-Protective Agents

Phase 3

Phosphodiesterase Inhibitors

Phase 3

Vasodilator Agents

Phase 3

Platelet Aggregation Inhibitors

Phase 3

Antioxidants

Phase 3

Protective Agents

Phase 3

Etoposide

Approved

Phase 2

33419-42-0

36462

Lenalidomide

Approved

Phase 2

191732-72-6

216326

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Vincristine

Approved, Investigational

Phase 2

2068-78-2, 57-22-7

5978

Prednisone

Approved, Vet_approved

Phase 2

53-03-2

5865

Doxorubicin

Approved, Investigational

Phase 2

23214-92-8

31703

Zidovudine

Approved

Phase 2

30516-87-1

35370

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Lamivudine

Approved, Investigational

Phase 2

134678-17-4

60825

Interferon beta-1a

Approved, Investigational

Phase 2

145258-61-3

Bortezomib

Approved, Investigational

Phase 1, Phase 2

179324-69-7

387447 93860

Rituximab

Approved

Phase 2

174722-31-7

Teriflunomide

Approved

Phase 1, Phase 2

108605-62-5, 163451-81-8

54677977 54684141

Nivolumab

Approved

Phase 2

946414-94-4

Anti-Bacterial Agents

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Alkylating Agents

Phase 2

Etoposide phosphate

Phase 2

16760419

Antineoplastic Agents, Alkylating

Phase 2

Hormones

Phase 2

Antimitotic Agents

Phase 2

Hormone Antagonists

Phase 2

Angiogenesis Inhibitors

Phase 2

Tubulin Modulators

Phase 2

glucocorticoids

Phase 2

Antibiotics, Antitubercular

Phase 2

Liposomal doxorubicin

Phase 2

Antimetabolites

Phase 2

Reverse Transcriptase Inhibitors

Phase 2

Interferon alpha-2

Phase 2

Lamivudine, zidovudine drug combination

Phase 2

interferons

Phase 2

Interferon-alpha

Phase 2

Adjuvants, Immunologic

Phase 2

Interferon-beta

Phase 2

Antirheumatic Agents

Phase 2

Anti-Inflammatory Agents

Phase 1, Phase 2

Immunosuppressive Agents

Phase 1, Phase 2

Immunologic Factors

Phase 2

Analgesics

Phase 1, Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 1, Phase 2

Analgesics, Non-Narcotic

Phase 1, Phase 2

Interventional clinical trials:

(show all 29)

#	Name	Status	NCT ID	Phase	Drugs
1	Open-Label, Exploratory Study of the Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)	Unknown status	NCT01343355	Phase 2, Phase 3	Tamibarotene
2	Effectiveness of Pentoxifylline in Attenuating Neurological Disease Associated With HTLV-1 and Negative Modulator of Pathological Immune Response.	Completed	NCT01472263	Phase 3	Pentoxifylline;Placebo
3	A Phase 3 Multicenter, Randomized, Double-Blind and Placebo-Controlled Study, and Open Study of KW-0761 in Patients With HTLV-1 Associated Myelopathy (HAM)	Terminated	NCT03191526	Phase 3	KW-0761 0.3 mg/kg IV;Placebo (saline)
4	Phase II Trial of Nivolumab for HTLV-Associated Adult T Cell Leukemia/Lymphoma	Completed	NCT02631746	Phase 2
5	Phase II Trial Of Induction Therapy With EPOCH Chemotherapy And Maintenance Therapy With Combivir/Interferon ALPHA-2a For HTLV-1 Associated T-Cell Non-Hodgkin's Lymphoma	Completed	NCT00041327	Phase 2	Etoposide;cyclophosphamide;doxorubicin hydrochloride;lamivudine;prednisone;vincristine sulfate;zidovudine
6	Combined Virological and Immunological Evaluation of Treatment of Patients With Early HTLV-1-Associated Myelopathy With Recombinant Human Interferon Beta-1a	Completed	NCT00001785	Phase 2	Recombinant human interferon beta-1a
7	Phase I/II Trial of Dose-Adjusted EPOCH Chemotherapy With Bortezomib Combined With Integrase Inhibitor Therapy for HTLV-1 Associated T-Cell Leukemia Lymphoma	Completed	NCT01000285	Phase 1, Phase 2	Bortezomib;Etoposide;Vincristine;Doxorubicin;Prednisone;Cyclophosphamide;Raltegravir
8	A Phase II Study of Lenalidomide in Patients With Relapsed or Refractory HTLV-1 Associated Adult T Cell Leukemia/Lymphoma	Completed	NCT01274533	Phase 2	Lenalidomide
9	Rituximab Therapy for the Patients With HTLV-1-associated Myelopathy	Recruiting	NCT04004819	Phase 2	Rituximab
10	Phase I/II Study of Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis	Recruiting	NCT04799288	Phase 1, Phase 2	Teriflunomide
11	Phase 2 Single-Arm, Open-Label Study of Nivolumab in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma (PTCL)	Terminated	NCT03075553	Phase 2
12	Phase II Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load	Withdrawn	NCT01620736	Phase 2	Raltegravir
13	A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive Bladder	Unknown status	NCT01640002	Phase 1	Propantheline Bromide;Placebo
14	Immunotherapy of Natural Killer in HTLV-1 Associated Myelopathy	Unknown status	NCT02961712	Phase 1
15	Phase I Study of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Using the Humanized MiK-Beta-1 Monoclonal Antibody Directed Toward the IL-2L-15R-Beta; Subunit (CD122) That Blocks IL-15 Action	Completed	NCT00076843	Phase 1	Hu MiK-Beta-1
16	A Clinical Pharmacological Study of MT-3921 in Subjects With Human T-cell Leukemia Virus Type 1 (HTLV-1)-Associated Myelopathy (HAM)	Recruiting	NCT05240612	Phase 1
17	A Phase 1 Study of Lenalidomide in Combination With EPOCH Chemotherapy for HTLV-Associated Adult T-Cell Leukemia-Lymphoma (ATLL)	Recruiting	NCT04301076	Phase 1	Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Lenalidomide;Prednisone;Vincristine Sulfate
18	Effects of Physiotherapy in the Treatment of Neurogenic Bladder in Patients Infected With Human T-Lymphotropic Virus 1	Completed	NCT01651819
19	Epidemic History and Iatrogenic Transmission of Blood-borne Viruses	Completed	NCT02439918
20	Therapeutic Effect of the Pilates Method in People With HAM/TSP: a Randomized Crossover Study	Completed	NCT04830319
21	Sensorimotor Exercises in Virtual Reality Platform and Balance in Individuals With Human T-lymphotropic Virus	Completed	NCT02877030
22	Effect of Raltegravir in Patients With Myelopathy/Tropical Spastic Paraparesis Associated With Infection by Human T-Lymphotropic Virus 1 (HTLV-1). Pilot Study	Completed	NCT02655471	Early Phase 1	"Raltegravir" and "Zidovudine"
23	Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)	Completed	NCT01867320	Early Phase 1	Raltegravir
24	MRI Investigation Of The CNS In HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)	Completed	NCT00034723
25	Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1	Completed	NCT01754311
26	Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)	Recruiting	NCT00001778
27	Physical Functional Impacts of Rehabilitation in Patients With Human Lymphotropic Virus Type I	Recruiting	NCT04875403
28	Caractérisation Clinico- Biologique et Survie Des Patients Porteurs d'Une lymphoprolifération HTLV-1 Induite (ou Lymphome/leucémie lié au Virus HTLV-1) et Des Patients infectés Par le Virus HTLV-1	Recruiting	NCT05237245
29	Collection of Blood, Bone Marrow and Tissue Samples for the Investigation of the Human Immune Response, Lymphoma Biology and HTLV-1 Infection	Recruiting	NCT00001582

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

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Genetic Tests for Human T-Cell Leukemia Virus Type 1

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Anatomical Context for Human T-Cell Leukemia Virus Type 1

Organs/tissues related to Human T-Cell Leukemia Virus Type 1:

MalaCards : T Cells, Breast, Bone Marrow, Bone, Spinal Cord, Brain, Monocytes

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Publications for Human T-Cell Leukemia Virus Type 1

Articles related to Human T-Cell Leukemia Virus Type 1:

(show top 50) (show all 5864)

#	Title	Authors	PMID	Year
1	ANK Therapeutic Prospects and Usefulness of PD-L1 and NK Activity as Biomarkers for Predicting Treatment Efficacy Revealed from the Treatment Course of Patients with HTLV-1-Associated Bronchioloalveolar Disease. ⁶²	Nagai K...Teshigawara K	36282976	2023
2	[Retracted] Effects of nutrients on matrix metalloproteinases in human T‑lymphotropic virus type 1 positive and negative malignant T‑lymphocytes. ⁶²	Harakeh S...Azar R	36367176	2023
3	Increasing horizontal transmission of human T-cell leukemia virus type 1 in adolescents and young adults in Japan. ⁶²	Sagara Y...Hamaguchi I	36370501	2022
4	Regulation of human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma. ⁶²	Madugula KK...Jain P	35615924	2022
5	Molecular insight into the study of adult T-cell leukemia/lymphoma (ATLL): Ten-year studies on HTLV-1 associated diseases in an endemic region. ⁶²	Ashrafi F...Abdolrahim Rezaee S	36108787	2022
6	A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells. ⁶²	Prawiro C...Bangham CRM	36442790	2022
7	HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation. ⁶²	Shen C...Xia Q	36450748	2022
8	Development of a Novel HTLV-1 Protease: Human Fcγ1 Recombinant Fusion Molecule in the CHO Eukaryotic Expression System. ⁶²	Ahmadi Ghezeldasht S...Rezaee SA	36399306	2022
9	Establishment of a Cynomolgus Macaque Model of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Direct Inoculation of Adult T-Cell Leukemia Patient-Derived Cell Lines for HTLV-1 Infection. ⁶²	Urano E...Yasutomi Y	36314828	2022
10	CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma. ⁶²	Kameda T...Shimoda K	36446869	2022
11	HTLV-I associated bronchioloalveolar disorder (HABA): disease concept and differential diagnosis of an unsolved disease entity. ⁶²	Ohmoto A...Katsura K	36437745	2022
12	Selective APC-targeting of a novel Fc-fusion multi-immunodominant recombinant protein (tTax-tEnv:mFcγ2a) for HTLV-1 vaccine development. ⁶²	Shafifar M...Rezaee SA	36044973	2022
13	Frequency and characteristics of HTLV in migrants: results from the +Redivi collaborative network in Spain. ⁶²	Norman FF...Lopez-Velez R	35166822	2022
14	Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4+ T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines. ⁶²	Fernandez-de Cespedes MV...Freed EO	36354340	2022
15	Dynamics and consequences of the HTLV-1 proviral plus-strand burst. ⁶²	Ramanayake S...Bangham CRM	36441826	2022
16	HTLV-1 Coinfection among Patients Attending a Large HIV Treatment Centre in Trinidad. ⁶²	Edwards RJ...Boyce G	36363801	2022
17	Current Interventions to Prevent HTLV-1 Mother-to-Child Transmission and Their Effectiveness: A Systematic Review and Meta-Analysis. ⁶²	Rosadas C...Taylor GP	36363819	2022
18	Decline in human T-cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a 12-year period (2006-2017). ⁶²	da Silva Malta MCF...Martins ML	35855523	2022
19	Antibiotic-Free Nanoplasmids as Promising Alternatives for Conventional DNA Vectors. ⁶²	Seyed N...Rafati S	36298575	2022
20	Intravenous immunoglobulin infusion contributes to a high incidence of false reactive screen results for human T-lymphotropic virus. ⁶²	Luo I...Chen R	35534285	2022
21	Chicken TAX1BP1 suppresses type I interferon production via degrading chicken MAVS and facilitates infectious bursal diseases virus replication. ⁶²	Hu X...Wu H	35793720	2022
22	Prevalence and Risk Factors for HTLV-1/2 Infection inRiverside and Rural Populations of the State of Pará. ⁶²	de Lima ACR...Feitosa RNM	36298817	2022
23	Discordance in the morphologic diagnosis of lymphocytes in HTLV-1-infected individuals. ⁶²	Fuji S...Ishikawa J	35702819	2022
24	Mannose binding lectin-associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T-lymphotropic virus type 1 (HTLV-1) infection in blood donors from Mashhad, Iran. ⁶²	Aghamohammadi A...Shahabi M	35924689	2022
25	Development of a nested real time PCR/high resolution melting assay for human T-cell lymphotropic viruses types 1 and 2 (HTLV-1 and 2) identification. ⁶²	Caputo M...Corach D	35634751	2022
26	VEGF Polymorphism rs3025039 and Human T-Cell Leukemia Virus 1 (HTLV-1) Infection among Older Japanese Individuals: A Cross-Sectional Study. ⁶²	Shimizu Y...Maeda T	36290496	2022
27	Comparison of Static Balance Control in Infected Htlv-1 Subjects with Different Tsp/Ham Diagnosis. ⁶²	Costa KHA...Callegari B	36366437	2022
28	Postural Adjustments in HTLV-1 Infected Patients during a Self-Initiated Perturbation. ⁶²	Almeida GCDS...Callegari B	36366487	2022
29	Herpes simplex virus type 2 (HSV-2) and its association with HIV, HCV, HBV, HTLV-1&2 and syphilis among men who have sex with men in Burkina Faso. ⁶²	Ouedraogo HG...Kouanda S	36241531	2022
30	Duodenal obstruction due to Strongyloides stercoralis in a patient with HTLV-1 infection. ⁶²	Harshan M...Arjun R	35833224	2022
31	Various types of electrochemical biosensors for leukemia detection and therapeutic approaches. ⁶²	Chupradit S...Bidares R	35588855	2022
32	The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development. ⁶²	Tornesello ML...Buonaguro FM	36358677	2022
33	Live attenuated VZV vaccination induces antitumor immunity in ATLL patients. ⁶²	Jo T...Shigematsu K	36181532	2022
34	Primary Effusion Lymphoma-like ATL Developing During Hemodialysis. ⁶²	Masaki M...Masaki Y	36261387	2022
35	HTLV infection in Brazil's second-largest indigenous reserve. ⁶²	Amianti C...Motta-Castro ARC	36202887	2022
36	Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression. ⁶²	Suzuki S...Ishitsuka K	36243685	2022
37	Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation. ⁶²	Davis DA...Yarchoan R	36290777	2022
38	Particularities of Neurological Manifestations in Adult T-Cell Leukemia/Lymphoma: Need for a Multidisciplinary Approach-A Narrative Review. ⁶²	Iordan I...Bumbea H	36363509	2022
39	TCL-150 Outcome of Stem Cell Transplantation in HTLV-1-Associated North American Adult T-Cell Leukemia/Lymphoma. ⁶²	Narvel H...Sica RA	36164124	2022
40	Signaling factors potentially associated to the pathogenesis of Adult T-cell leukemia /lymphoma: A network-analysis and novel findings assessment. ⁶²	Mozhgani SH...Rezaee SA	35868352	2022
41	The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis. ⁶²	Oliveira PD...Bittencourt AL	36260617	2022
42	[Clinical Study of Chemotherapy Combined with Antivirals for Adult T-cell Leukemia/Lymphoma]. ⁶²	Lin Y...Chen Q	36208242	2022
43	HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management. ⁶²	Wolf S...Cook L	35880453	2022
44	[Murine Models of Chronic Viral Infections and Associated Cancers]. ⁶²	Avdoshina DV...Bayurova EO	36165012	2022
45	Co-Infection and Cancer: Host-Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses. ⁶²	Mulherkar TH...Jain P	36146843	2022
46	Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy. ⁶²	Hatayama Y...Ryo A	36298708	2022
47	Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines. ⁶²	Pise-Masison CA...Franchini G	36298639	2022
48	In silico identification of epitope-based vaccine candidates against HTLV-1. ⁶²	Jahantigh HR...Ahmadi K	33648421	2022
49	Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia. ⁶²	Takeda A...Sonoda KH	36034764	2022
50	KIR3DL2 contributes to the typing of acute adult T-cell leukemia and is a potential therapeutic target. ⁶²	Cheminant M...Hermine O	35687761	2022

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Genes for Human T-Cell Leukemia Virus Type 1

Genes related to Human T-Cell Leukemia Virus Type 1 (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	26.47	GeneCards inferred via : Publications Proteins Functions (show sections)
2	CRTC3	CREB Regulated Transcription Coactivator 3	Protein Coding	17.24	GeneCards inferred via : Publications Functions (show sections)
3	CRTC1	CREB Regulated Transcription Coactivator 1	Protein Coding	16.84	GeneCards inferred via : Publications Functions (show sections)
4	RPL6	Ribosomal Protein L6	Protein Coding	8.59	GeneCards inferred via : Summaries (show sections)
5	APOBEC3A	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A	Protein Coding	7.66	GeneCards inferred via : Functions (show sections)
6	APOBEC3B	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B	Protein Coding	7.66	GeneCards inferred via : Functions (show sections)
7	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	7.66	GeneCards inferred via : Functions (show sections)

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Variations for Human T-Cell Leukemia Virus Type 1

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Expression for Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

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Pathways for Human T-Cell Leukemia Virus Type 1

Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cellular responses to stimuli ⁶⁶ Show member pathways Cellular responses to stress ⁶⁶	12.87	RPL6 CRTC3 CRTC2 CRTC1
2	Organelle biogenesis and maintenance ⁶⁶ Show member pathways Cilium Assembly ⁶⁶	12.19	CRTC3 CRTC2 CRTC1
3	Glucose / Energy Metabolism ³	11.92	CRTC3 CRTC2 CRTC1
4	Transcriptional activation of mitochondrial biogenesis ⁶⁶ Show member pathways Activation of PPARGC1A (PGC-1alpha) by phosphorylation ⁶⁶ Cristae formation ⁶⁶ Formation of ATP by chemiosmotic coupling ⁶⁶ Mitochondrial biogenesis ⁶⁶ Mitochondrial transcription initiation ⁶⁶ Mitochondrial transcription termination ⁶⁶ Transcription from mitochondrial promoters ⁶⁶	11.47	CRTC3 CRTC2 CRTC1
5	Circadian Clock ⁶⁶ Show member pathways BMAL1:CLOCK,NPAS2 activates circadian gene expression ⁶⁶ Circadian Clock in Mammals ⁶⁴ Heme signaling ⁶⁶ NR1D1 (REV-ERBA) represses gene expression ⁶⁶ RORA activates gene expression ⁶⁶	11.05	CRTC3 CRTC2 CRTC1
6	mRNA Editing: C to U Conversion ⁶⁶ Show member pathways Formation of the Editosome ⁶⁶ mRNA Editing ⁶⁶	10.62	APOBEC3B APOBEC3A

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GO Terms for Human T-Cell Leukemia Virus Type 1

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to virus	GO:0051607	9.93	BST2 APOBEC3B APOBEC3A
2	negative regulation of viral genome replication	GO:0045071	9.8	BST2 APOBEC3A
3	energy homeostasis	GO:0097009	9.78	CRTC3 CRTC1
4	negative regulation of transposition	GO:0010529	9.73	APOBEC3B APOBEC3A
5	DNA demethylation	GO:0080111	9.71	APOBEC3B APOBEC3A
6	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	GO:0045869	9.67	APOBEC3B APOBEC3A
7	cytidine deamination	GO:0009972	9.62	APOBEC3A APOBEC3B
8	cytidine to uridine editing	GO:0016554	9.56	APOBEC3A APOBEC3B
9	DNA cytosine deamination	GO:0070383	9.46	APOBEC3B APOBEC3A
10	protein homotetramerization	GO:0051289	9.43	CRTC3 CRTC2 CRTC1
11	positive regulation of CREB transcription factor activity	GO:0032793	9.1	CRTC3 CRTC2 CRTC1

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytidine deaminase activity	GO:0004126	9.46	APOBEC3B APOBEC3A
2	deoxycytidine deaminase activity	GO:0047844	9.26	APOBEC3A APOBEC3B
3	cAMP response element binding protein binding	GO:0008140	9.1	CRTC3 CRTC2 CRTC1