MCID: HMN021
MIFTS: 50

Human T-Cell Leukemia Virus Type 1

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Human T-Cell Leukemia Virus Type 1

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 1:

Name: Human T-Cell Leukemia Virus Type 1 53
Human T Lymphotropic Virus Type 1 53
Htlv-1 53

Classifications:



Summaries for Human T-Cell Leukemia Virus Type 1

NIH Rare Diseases : 53 Human T-cell leukemia virus, type 1 (HTLV-1) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, some affected people may later develop adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) or other medical conditions. HTLV-1 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-1 and it is considered a lifelong condition; however, most (95%) infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 1, also known as human t lymphotropic virus type 1, is related to human t-cell leukemia virus type 2 and glioblastoma. An important gene associated with Human T-Cell Leukemia Virus Type 1 is CRTC2 (CREB Regulated Transcription Coactivator 2), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Valproic acid and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone, and related phenotypes are Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection and Decreased TP53 mRNA expression

Wikipedia : 75 Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the... more...

Related Diseases for Human T-Cell Leukemia Virus Type 1

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 human t-cell leukemia virus type 2 29.7 NFKB1 EP300 CREBBP CREB1 CNTN2
2 glioblastoma 27.9 CNTN2 CDKN1A CDK4 CDK2
3 t-cell leukemia 26.9 XPO1 NFKB1 JUN GLI2 EP300 CRTC3
4 infective dermatitis associated with htlv-1 12.4
5 htlv-1 associated myelopathy/tropical spastic paraparesis 12.1
6 adult t-cell leukemia 12.0
7 retrovirus-associated myelopathy 11.6
8 intermediate uveitis 11.5
9 leukemia, t-cell, chronic 11.4
10 pars planitis 11.2
11 myelopathy, htlv-1-associated 10.9
12 spastic paraparesis 10.9
13 tropical spastic paraparesis 10.9
14 human immunodeficiency virus type 1 10.7
15 leukemia 10.7
16 t-cell adult acute lymphocytic leukemia 10.6
17 lymphoma 10.5
18 stomatitis 10.5
19 strongyloidiasis 10.5
20 lymphocytic leukemia 10.4
21 dermatitis 10.4
22 polymyositis 10.3
23 paraplegia 10.3
24 leukemia, chronic lymphocytic 10.3
25 retinoblastoma 10.3
26 immune deficiency disease 10.3
27 osteogenic sarcoma 10.3
28 hepatitis c virus 10.3
29 uveitis 10.3
30 vaccinia 10.3
31 familial retinoblastoma 10.3
32 mycosis fungoides 10.3
33 myopathy 10.3
34 myositis 10.3
35 melanoma of soft tissue 10.3 CREB1 ATF1
36 autoimmune disease 10.2
37 hypercalcemia, infantile, 1 10.2
38 leukemia, acute lymphoblastic 10.2
39 helix syndrome 10.2
40 diphtheria 10.2
41 arthropathy 10.2
42 severe combined immunodeficiency 10.2
43 b-cell lymphoma 10.2
44 herpes simplex 10.2
45 glioma 10.2
46 leukemia, b-cell, chronic 10.2
47 glial tumor 10.2
48 acute liver failure 10.2
49 meningitis 10.2
50 retinal vasculitis 10.2

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 1:



Diseases related to Human T-Cell Leukemia Virus Type 1

Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 1

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 9.33 CDK2 CDK4 CHUK
2 Decreased TP53 mRNA expression GR00389-S-5 9.13 CREB1 JUN NFKB1
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CDK2 CDKN1A EP300 JUN NFKB1

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 1:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.32 CDK2 CDK4 CDKN1A CHUK CREB1 CREBBP
2 homeostasis/metabolism MP:0005376 10.32 CCND2 CDK2 CDK4 CDKN1A CHUK CREB1
3 endocrine/exocrine gland MP:0005379 10.29 CCND2 CDK2 CDK4 CDKN1A CHUK CREB1
4 growth/size/body region MP:0005378 10.28 CDK2 CDK4 CDKN1A CHUK CREB1 CREBBP
5 behavior/neurological MP:0005386 10.25 CCND2 CDK4 CDKN1A CNTN2 CREB1 CREBBP
6 cardiovascular system MP:0005385 10.24 CCND2 CDK2 CDK4 CDKN1A CHUK CREB1
7 embryo MP:0005380 10.21 CDK2 CDK4 CDKN1A CHUK CREB1 CREBBP
8 hematopoietic system MP:0005397 10.18 CCND2 CDK2 CDK4 CDKN1A CHUK CREBBP
9 mortality/aging MP:0010768 10.18 CCND2 CDK2 CDK4 CDKN1A CHUK CREB1
10 immune system MP:0005387 10.15 CCND2 CDK2 CDK4 CDKN1A CHUK CREBBP
11 liver/biliary system MP:0005370 10.13 CCND2 CDK2 CDK4 CDKN1A CHUK CREBBP
12 digestive/alimentary MP:0005381 10.11 CDK4 CDKN1A CHUK CREBBP EP300 GLI2
13 integument MP:0010771 10.08 CDK2 CDK4 CDKN1A CHUK CREBBP GLI2
14 craniofacial MP:0005382 10.05 CDKN1A CHUK CREBBP EP300 GLI2 NFKB1
15 muscle MP:0005369 10.02 CDK2 CDK4 CDKN1A CREB1 CREBBP CRTC3
16 nervous system MP:0003631 10 CCND2 CDK4 CDKN1A CHUK CNTN2 CREB1
17 limbs/digits/tail MP:0005371 9.93 CDKN1A CHUK CNTN2 CREBBP CRTC3 GLI2
18 neoplasm MP:0002006 9.8 CDK2 CDK4 CDKN1A CHUK CREBBP EP300
19 respiratory system MP:0005388 9.76 CDKN1A CHUK CREB1 CREBBP EP300 GLI2
20 skeleton MP:0005390 9.56 CDKN1A CHUK CREB1 CREBBP CRTC3 GLI2
21 vision/eye MP:0005391 9.23 CCND2 CDK2 CDK4 CDKN1A CHUK EP300

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 1

Drugs for Human T-Cell Leukemia Virus Type 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
2
Zidovudine Approved Phase 4 30516-87-1 35370
3
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
4 Anti-Infective Agents Phase 4
5 Anti-HIV Agents Phase 4
6 Anti-Retroviral Agents Phase 4
7 Antiviral Agents Phase 4
8 Immunologic Factors Phase 4
9 Antimetabolites Phase 4
10 Neurotransmitter Agents Phase 4
11 Anticonvulsants Phase 4
12 interferons Phase 4
13 Tranquilizing Agents Phase 4
14 Central Nervous System Depressants Phase 4
15 GABA Agents Phase 4
16 Psychotropic Drugs Phase 4
17 Antimanic Agents Phase 4
18 Nucleic Acid Synthesis Inhibitors Phase 4
19 Reverse Transcriptase Inhibitors Phase 4
20 Interferon alpha-2 Phase 4
21 Interferon-alpha Phase 4
22
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
23
Lopinavir Approved Phase 2, Phase 3 192725-17-0 92727
24
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
25
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
26
Ivermectin Approved, Investigational, Vet_approved Phase 3 70288-86-7 6474909
27
Mogamulizumab Approved, Investigational Phase 3 1159266-37-1
28 Raltegravir Potassium Phase 2, Phase 3
29 Integrase Inhibitors Phase 2, Phase 3
30 HIV Integrase Inhibitors Phase 2, Phase 3
31 HIV Protease Inhibitors Phase 2, Phase 3
32 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
33
protease inhibitors Phase 2, Phase 3
34 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
35 Free Radical Scavengers Phase 3
36 Antioxidants Phase 3
37 Phosphodiesterase Inhibitors Phase 3
38 Protective Agents Phase 3
39 Radiation-Protective Agents Phase 3
40 Platelet Aggregation Inhibitors Phase 3
41 Vasodilator Agents Phase 3
42 Antiparasitic Agents Phase 3
43
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
44
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
45
Vincristine Approved, Investigational Phase 1, Phase 2 57-22-7, 2068-78-2 5978
46
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
47
Bortezomib Approved, Investigational Phase 1, Phase 2 179324-69-7 93860 387447
48
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
49
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
50
Lenalidomide Approved Phase 2 191732-72-6 216326

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Prospective Study of the Molecular Characteristics of Sensitive and Resistant Disease in Patients With HTLV-I Associated Adult T Cell Leukemia Treated With Zidovudine (AZT) Plus Interferon Alpha-2b Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
2 Open-Label, Exploratory Study of the Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Evaluation of the Use of Antiretroviral Regimens Containing Raltegravir for Prophylaxis of Mother-to-child-transmission of HIV Infection in Pregnant Women Presenting With Detectable Viral Load After 32 Weeks of Gestation: a Pilot Study Unknown status NCT01854762 Phase 2, Phase 3 Raltegravir;Lopinavir/Ritonavir
4 Effectiveness of Pentoxifylline in Attenuating Neurological Disease Associated With HTLV-1 and Negative Modulator of Pathological Immune Response. Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
5 Study Of Valproic Acid To Treat TSP/HAM Patients In Sao Paulo, Brazil Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
6 A Comparative Study of Two Regimens of Ivermectin for the Treatment of Strongyloides Stercoralis Infection Recruiting NCT03605758 Phase 3 Ivermectin
7 A Phase 3 Multicenter, Randomized, Double-Blind and Placebo-Controlled Study, and Open Study of KW-0761 in Patients With HTLV-1 Associated Myelopathy (HAM) Active, not recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
8 Randomized Study of Romidepsin Versus the Combination of Romidepsin Plus Pralatrexate in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL) Withdrawn NCT03355768 Phase 3 Romidepsin;Pralatrexate
9 A Phase I/II Study of the Efficacy and Toxicity of Humanized Anti-Tac (Zenapax(Trademark)) in the Therapy of Tac-Expressing Adult T-Cell Leukemia Completed NCT00001941 Phase 1, Phase 2
10 Phase I/II Trial of Dose-Adjusted EPOCH Chemotherapy With Bortezomib Combined With Integrase Inhibitor Therapy for HTLV-1 Associated T-Cell Leukemia Lymphoma Completed NCT01000285 Phase 1, Phase 2 Bortezomib;Etoposide;Vincristine;Doxorubicin;Prednisone;Cyclophosphamide;Raltegravir
11 Combined Virological and Immunological Evaluation of Treatment of Patients With Early HTLV-1-Associated Myelopathy With Recombinant Human Interferon Beta-1a Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
12 A Phase II Study of Lenalidomide in Patients With Relapsed or Refractory HTLV-1 Associated Adult T Cell Leukemia/Lymphoma Completed NCT01274533 Phase 2 Lenalidomide
13 Phase II Trial Of Induction Therapy With EPOCH Chemotherapy And Maintenance Therapy With Combivir/Interferon ALPHA-2a For HTLV-1 Associated T-Cell Non-Hodgkin's Lymphoma Completed NCT00041327 Phase 2 Etoposide;cyclophosphamide;doxorubicin hydrochloride;lamivudine;prednisone;vincristine sulfate;zidovudine
14 Phase II Study of the Efficacy and Toxicity of Campath-1H in the Therapy of Adult T-Cell Leukemia Completed NCT00061048 Phase 2
15 A Phase 1/2a Open-label Study of Pralatrexate and Gemcitabine With Vitamin B12 and Folic Acid Supplementation in Patients With Relapsed or Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
16 Phase II Study of Therapy With IMTOX-25 in Adults With Refractory/Relapsed Cd25 Positive Adult T Cell Leukemia/Lymphoma Completed NCT01378871 Phase 2 IMTOX-25
17 Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) to Treat Persistent Reactivation Or Infection With Adenovirus, CMV and EBV After Hemopoietic Stem Cell Transplantation (HSCT) Completed NCT00711035 Phase 1, Phase 2
18 Phase II Trial Evaluating the Safety and Efficacy of Ruxolitinib in Patients With Smoldering and Chronic Adult T-cell Leukemia (ATL) Recruiting NCT01712659 Phase 2 Ruxolitinib;ruxolitinib
19 A Phase II Trial of Belinostat as Consolidation Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Recruiting NCT02737046 Phase 2 Belinostat;Zidovudine;Interferon-Alfa-2b;Pegylated Interferon-Alfa-2b
20 Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia Active, not recruiting NCT00924170 Phase 1, Phase 2 LMB-2;Fludarabine;Cyclophosphamide
21 Phase II Trial of Nivolumab for HTLV-Associated Adult T Cell Leukemia/Lymphoma Active, not recruiting NCT02631746 Phase 2
22 Extended Dose - Total Body Irradiation Followed By Allogeneic Stem Cell Transplantation For The Treatment Of Refractory Acute Leukemia And Advanced Myelodysplastic Syndrome Suspended NCT01709396 Phase 2
23 Phase II Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load Withdrawn NCT01620736 Phase 2 Raltegravir
24 Immunotherapy of Natural Killer in HTLV-1 Associated Myelopathy Unknown status NCT02961712 Phase 1
25 A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive Bladder Unknown status NCT01640002 Phase 1 Propantheline Bromide;Placebo
26 Human OK99 Allogeneic Stem Cell Transplantation for Patients With Severe Parkinson's Disease Unknown status NCT02780895 Phase 1 Human Stem Cells
27 Phase I Study of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Using the Humanized MiK-Beta-1 Monoclonal Antibody Directed Toward the IL-2L-15R-Beta; Subunit (CD122) That Blocks IL-15 Action Completed NCT00076843 Phase 1 Hu MiK-Beta-1
28 A Phase I, Multicenter, Open-label, Dose-escalation Study to Assess the Safety of Lenalidomide in Patients With Advanced Adult T-cell Leukemia-lymphoma and Peripheral T-cell Lymphoma Completed NCT01169298 Phase 1 Lenalidomide
29 A Phase I Study Of Subcutaneous Recombinant Human IL-15 (S.C.rhIL-15) and Alemtuzumab for Patients With Refractory or Relapsed Chronic and Acute Adult T-Cell Leukemia (ATL) Suspended NCT02689453 Phase 1
30 Biomarker Discovery In Children With Autism Plus Familial Autoimmune History Completed NCT01541033
31 Effects of Physiotherapy in the Treatment of Neurogenic Bladder in Patients Infected With Human T-Lymphotropic Virus 1 Completed NCT01651819
32 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
33 Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP) Completed NCT01867320 Early Phase 1 Raltegravir
34 Sensorimotor Exercises in Virtual Reality Platform and Balance in Individuals With Human T-lymphotropic Virus Completed NCT02877030
35 Effect of Raltegravir in Patients With Myelopathy/Tropical Spastic Paraparesis Associated With Infection by Human T-Lymphotropic Virus 1 (HTLV-1). Pilot Study Completed NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
36 Signaling in Tumorigenesis and Immunity Completed NCT01520246
37 MRI Investigation Of The CNS In HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00034723
38 A Study of Familial and Genetic Aspects of Adult T-Cell Leukemia/Lymphoma, Tropical Spastic Paraparesis and Infective Dermatitis in Jamaica Completed NCT00340821
39 Epidemic History and Iatrogenic Transmission of Blood-borne Viruses Completed NCT02439918
40 Prediagnostic Markers of Adult T-Cell Leukemia/Lymphoma Among Carriers of Human T-Lymphoma Virus Type I: A Collaborative Study Completed NCT00339638
41 Analysis of Clinical and Immunological Characteristics, as Well as Pathophysiological Mechanisms in a French Cohort of Patients With Idiopathic CD4 Lymphocytopenia Completed NCT02113930
42 NIB Repository Protocol Completed NCT01581567
43 Natural History of HTVL-I: A Cross-Sectional Study of a Cohort of Blood Donors in Jamaica Completed NCT00339807
44 Late Effects of Treatment in Survivors of Pediatric Sarcomas Completed NCT00006515
45 Immuno-Virological Evaluation of Human T Cell Lymphotropic Virus Infection and Associated Neurological Diseases Recruiting NCT00001778
46 Collection of Blood, Bone Marrow and Tissue Samples for the Investigation of the Human Immune Response, Lymphoma Biology and HTLV-1 Infection Recruiting NCT00001582
47 Collection of Blood, Bone Marrow, Tumor, or Tissue Samples From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-Malignant Lesions, and/or Cancer Recruiting NCT00006518
48 Electromiography Study in the Respiratory Muscle Training in Human Lymphotropic Virus Type 1 Recruiting NCT03829709
49 Epidemiological and Molecular Aspects of the Interspecies Transmission of Foamy Viruses From Monkeys to Humans: A Model of the Early Stages of Viral Emergence. Recruiting NCT03225794
50 Autologous Ovarian Tissue Transplantation Recruiting NCT03496636

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 1

Genetic Tests for Human T-Cell Leukemia Virus Type 1

Anatomical Context for Human T-Cell Leukemia Virus Type 1

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 1:

41
T Cells, Breast, Bone, Bone Marrow, B Cells, Brain, Lung

Publications for Human T-Cell Leukemia Virus Type 1

Articles related to Human T-Cell Leukemia Virus Type 1:

(show top 50) (show all 2026)
# Title Authors PMID Year
1
Current mechanistic insights into the role of infection in systemic lupus erythematosus. 38
31226637 2019
2
Conflicting effects of poly(ADP-ribose) polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection. 38
31299194 2019
3
Complete sequence of human T cell leukemia virus type 1 in ATLL patients from Northeast Iran, Mashhad revealed a prematurely terminated protease and an elongated pX open reading frame III. 38
31102740 2019
4
Comparative virology of HTLV-1 and HTLV-2. 38
31391116 2019
5
Hodgkin-like adult T-cell leukemia/lymphoma that developed during the follow-up of HTLV-1 associated myelopathy/tropical spastic paraparesis. 38
31391405 2019
6
Current approaches for detection of human T-lymphotropic virus Type 1: A systematic review. 38
30633358 2019
7
Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 Activities In Vitro and In Vivo. 38
31167921 2019
8
Clinicopathological analysis of sinonasal malignant lymphoma in an HTLV-1 endemic area in Japan-special focus on primary sinonasal diffuse large B-cell lymphoma. 38
31391402 2019
9
Novel Interactions between the Human T-Cell Leukemia Virus Type 1 Antisense Protein HBZ and the SWI/SNF Chromatin Remodeling Family: Implications for Viral Life Cycle. 38
31142665 2019
10
Development and evaluation of human T-cell leukemia virus-1 and -2 multiplex quantitative PCR. 38
31429972 2019
11
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure. 38
31233774 2019
12
Prevalence and Molecular Epidemiology of Human T-Lymphotropic Virus Type 1 among Women Attending Antenatal Clinics in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. 38
31407658 2019
13
Essential Role of HTLV-1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice. 38
31315992 2019
14
Cutaneous manifestations of adult T-cell leukemia/lymphoma. 38
31387753 2019
15
High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments. 38
31292228 2019
16
Adult T-Cell Leukemia After Deceased Donor Liver Transplantation for Acute Liver Failure: A Case Report. 38
31303413 2019
17
Effects of radiation based on whole-body irradiation in HTLV-1-infected mice. 38
31322703 2019
18
The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability. 38
31299491 2019
19
HTLV-1 bZIP factor upregulates the expression of ICAM-1 to facilitate HTLV-1 infection. 38
31315993 2019
20
The prevalence of human T-lymphotropic virus type 1 & 2 (HTLV-1/2) in South African blood donors. 38
30950074 2019
21
An Immunodominant and Conserved B-Cell Epitope in the Envelope of Simian Foamy Virus Recognized by Humans Infected with Zoonotic Strains from Apes. 38
30894477 2019
22
Prevalence of Human T-lymphotropic Virus Type 1 (HTLV-1) Infection in Patients with Different Etiologies. 38
31356103 2019
23
Prevalence of Human T-lymphotropic Virus Type 1 (HTLV-1) Infection in Different Geographical Locations. 38
31356104 2019
24
Circulating miR-29c, miR-30c, miR-193a-5p and miR-885-5p: Novel potential biomarkers for HTLV-1 infection diagnosis. 38
31242452 2019
25
Regulatory T cells and IgE expression in duodenal mucosa of Strongyloides stercoralis and human T lymphotropic virus type 1 co-infected patients. 38
31170141 2019
26
Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern. 38
30693421 2019
27
Rapid onset and progression of myelopathy following an STI: a case for screening? 38
30824578 2019
28
Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma. 38
31041884 2019
29
Pathogenicity of Mycolicibacterium phlei, a non-pathogenic nontuberculous mycobacterium in an immunocompetent host carrying anti-interferon gamma autoantibodies: a case report. 38
31117976 2019
30
Intrinsically Disordered Human T Lymphotropic Virus Type 1 p30 Protein: Experimental and Computational Evidence. 38
30618266 2019
31
Induction of APOBEC3B cytidine deaminase in HTLV-1-infected humanized mice. 38
30988755 2019
32
Human T lymphotropic virus type 1 and risk of cardiovascular disease: High-density lipoprotein dysfunction versus serum HDL-C concentrations. 38
30693992 2019
33
Enhanced T-cell maturation and monocyte aggregation are features of cellular inflammation in human T-lymphotropic virus type-1-associated myelopathy. 38
31063543 2019
34
Molecular biology of human T cell leukemia virus. 38
31103249 2019
35
Diversity of cell phenotypes among MT-2 cell lines affects the growth of U937 cells and cytokine production. 38
30560508 2019
36
Clinical features and human T-cell leukemia virus type-1 (HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single center cohort study. 38
30938551 2019
37
Association of high levels of plasma OX40 with acute adult T-cell leukemia. 38
30652238 2019
38
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. 38
30657736 2019
39
Maintenance of long remission in adult T-cell leukemia by Tax-targeted vaccine: A hope for disease-preventive therapy. 38
30666755 2019
40
Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection. 38
30452989 2019
41
Myelopathy due to human T-cell leukemia virus type-1 from the donor after ABO-incompatible liver transplantation. 38
31029562 2019
42
Can we reduce the incidence of adult T-cell leukaemia/lymphoma? Cost-effectiveness of human T-lymphotropic virus type 1 (HTLV-1) antenatal screening in the United Kingdom. 38
29676441 2019
43
Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription. 38
30782173 2019
44
Cells of adult T-cell leukemia evade HTLV-1 Tax/NF-κB hyperactivation-induced senescence. 38
30787019 2019
45
Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain. 38
30815504 2019
46
Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein. 38
30566619 2019
47
Multiplex Droplet Digital PCR Assay for Quantification of Human T-Cell Leukemia Virus Type 1 Subtype c DNA Proviral Load and T Cells from Blood and Respiratory Exudates Sampled in a Remote Setting. 38
30518541 2019
48
Short Communication: Human Bone Marrow Stromal Cells Exhibit Immunosuppressive Effects on Human T Lymphotropic Virus Type 1 T Lymphocyte from Infected Individuals. 38
30351194 2019
49
A Case of Adult T-Cell Leukemia/Lymphoma Complicated with Bilateral Chylothorax. 38
30911425 2019
50
RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma. 38
31069115 2019

Variations for Human T-Cell Leukemia Virus Type 1

Expression for Human T-Cell Leukemia Virus Type 1

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 1.

Pathways for Human T-Cell Leukemia Virus Type 1

Pathways related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.24 XPO1 NFKB1 JUN GLI2 EP300 CREBBP
2
Show member pathways
13.91 NFKB1 JUN EP300 CREBBP CREB1 CHUK
3
Show member pathways
13.77 XPO1 NFKB1 JUN EP300 CREBBP CREB1
4
Show member pathways
13.76 XPO1 NFKB1 JUN EP300 CREBBP CREB1
5
Show member pathways
13.59 NFKB1 JUN EP300 CREBBP CREB1 CHUK
6
Show member pathways
13.56 NFKB1 JUN EP300 CREBBP CREB1 CNTN2
7
Show member pathways
13.3 NFKB1 JUN EP300 CREBBP CREB1 CHUK
8
Show member pathways
13.23 NFKB1 JUN EP300 CREBBP CDKN1A CDK4
9
Show member pathways
13.12 NFKB1 JUN GLI2 EP300 CREBBP CREB1
10
Show member pathways
13.04 NFKB1 JUN EP300 CREBBP CHUK CDKN1A
11
Show member pathways
13.02 JUN EP300 CREBBP CDKN1A CDK2
12
Show member pathways
13.01 NFKB1 JUN EP300 CREBBP CREB1 CHUK
13
Show member pathways
12.99 NFKB1 EP300 CRTC2 CREBBP CREB1 CHUK
14
Show member pathways
12.98 NFKB1 JUN CREB1 CHUK ATF1
15
Show member pathways
12.96 NFKB1 JUN EP300 CREBBP CREB1 CHUK
16
Show member pathways
12.95 NFKB1 JUN EP300 CREBBP CHUK
17
Show member pathways
12.91 NFKB1 JUN EP300 CREBBP CREB1 CHUK
18
Show member pathways
12.88 NFKB1 JUN CREB1 CHUK CDKN1A ATF1
19 12.83 NFKB1 JUN GLI2 EP300 CREBBP CHUK
20
Show member pathways
12.79 JUN EP300 CDKN1A CDK4 CDK2 CCND2
21
Show member pathways
12.78 NFKB1 JUN CREBBP CREB1 CHUK
22
Show member pathways
12.74 NFKB1 JUN EP300 CREBBP CREB1
23
Show member pathways
12.69 NFKB1 JUN EP300 CREBBP CDKN1A
24
Show member pathways
12.67 CREB1 CDKN1A CDK4 CDK2 CCND2
25
Show member pathways
12.67 NFKB1 JUN CREB1 CHUK CDK4
26 12.64 NFKB1 EP300 CREBBP CDKN1A CCND2
27
Show member pathways
12.6 NFKB1 JUN CREB1 ATF1
28 12.57 CDKN1A CDK4 CDK2 CCND2
29
Show member pathways
12.57 NFKB1 JUN EP300 CREBBP CREB1 CHUK
30
Show member pathways
12.51 NFKB1 JUN CREB1 CHUK
31
Show member pathways
12.51 NFKB1 EP300 CREBBP CHUK
32
Show member pathways
12.51 NFKB1 EP300 CREBBP CHUK
33
Show member pathways
12.5 NFKB1 EP300 CREB1 CHUK CDKN1A CCND2
34
Show member pathways
12.49 CREB1 CDKN1A CDK4 CDK2 CCND2
35 12.49 JUN CREBBP CREB1 CHUK CDK4 CDK2
36
Show member pathways
12.48 NFKB1 JUN CREB1 CHUK
37
Show member pathways
12.48 NFKB1 JUN CREB1 CHUK
38
Show member pathways
12.48 NFKB1 JUN CREB1 CHUK
39
Show member pathways
12.47 EP300 CREBBP CDKN1A CCND2
40
Show member pathways
12.47 NFKB1 JUN EP300 CHUK
41 12.46 EP300 CREBBP CDKN1A CDK4 CDK2 CCND2
42
Show member pathways
12.44 CDKN1A CDK4 CDK2 CCND2
43
Show member pathways
12.44 EP300 CREBBP CDKN1A CDK2
44 12.44 NFKB1 JUN EP300 CREBBP CREB1
45
Show member pathways
12.42 NFKB1 JUN CREB1 CHUK
46
Show member pathways
12.42 NFKB1 JUN EP300 CREB1 CHUK ATF1
48
Show member pathways
12.37 NFKB1 JUN CREB1 CHUK CDK2
49
Show member pathways
12.36 JUN EP300 CREBBP CCND2
50 12.35 NFKB1 CDKN1A CCND2 ATF1

GO Terms for Human T-Cell Leukemia Virus Type 1

Cellular components related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.5 XPO1 NFKB1 JUN GLI2 EP300 CRTC3
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.46 CDKN1A CDK4 CDK2 CCND2
3 transcription factor complex GO:0005667 9.43 JUN EP300 CREB1 CDK4 CDK2 ATF1
4 cytoplasm GO:0005737 10.15 XPO1 NFKB1 GLI2 EP300 CRTC3 CRTC2
5 nucleus GO:0005634 10.13 XPO1 NFKB1 JUN GLI2 EP300 CRTC3
6 cytosol GO:0005829 10.06 XPO1 NFKB1 JUN GLI2 EP300 CRTC3

Biological processes related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 NFKB1 JUN GLI2 CDKN1A CCND2
2 positive regulation of cell proliferation GO:0008284 9.97 JUN GLI2 CDK4 CDK2 CCND2
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 XPO1 NFKB1 JUN GLI2 EP300 CREBBP
4 viral process GO:0016032 9.85 XPO1 EP300 CRTC3 CRTC2 CREBBP CREB1
5 response to organic cyclic compound GO:0014070 9.83 JUN CDKN1A ATF1
6 regulation of cell cycle GO:0051726 9.83 JUN EP300 CDK4 CDK2
7 rhythmic process GO:0048511 9.82 EP300 CREBBP CREB1
8 Fc-epsilon receptor signaling pathway GO:0038095 9.81 NFKB1 JUN CHUK
9 response to toxic substance GO:0009636 9.77 CHUK CDKN1A CDK4
10 G1/S transition of mitotic cell cycle GO:0000082 9.76 CDKN1A CDK4 CDK2
11 Ras protein signal transduction GO:0007265 9.73 JUN CDKN1A CDK2
12 circadian rhythm GO:0007623 9.73 JUN EP300 CREB1 CDK4
13 response to drug GO:0042493 9.73 XPO1 JUN CREB1 CHUK CDKN1A CDK4
14 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.72 EP300 CDKN1A CDK2
15 positive regulation of fibroblast proliferation GO:0048146 9.71 JUN CDKN1A CDK4
16 positive regulation of type I interferon production GO:0032481 9.67 NFKB1 EP300 CREBBP
17 transcription by RNA polymerase II GO:0006366 9.65 NFKB1 JUN CREB1
18 positive regulation of transcription of Notch receptor target GO:0007221 9.64 EP300 CREBBP
19 positive regulation of CREB transcription factor activity GO:0032793 9.63 CRTC3 CRTC2
20 positive regulation by host of viral transcription GO:0043923 9.63 JUN EP300
21 positive regulation of DNA replication GO:0045740 9.63 JUN GLI2 ATF1
22 response to muscle stretch GO:0035994 9.62 NFKB1 JUN
23 response to hyperoxia GO:0055093 9.62 CDKN1A CDK4
24 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.62 NFKB1 EP300 CREBBP CHUK
25 protein acetylation GO:0006473 9.61 EP300 CREBBP
26 positive regulation of transcription, DNA-templated GO:0045893 9.56 NFKB1 JUN GLI2 EP300 CREBBP CREB1
27 response to organic substance GO:0010033 9.55 JUN CREB1 CHUK CDKN1A CDK4
28 N-terminal peptidyl-lysine acetylation GO:0018076 9.51 EP300 CREBBP
29 positive regulation of transcription by RNA polymerase II GO:0045944 9.32 NFKB1 JUN GLI2 EP300 CRTC3 CRTC2
30 protein phosphorylation GO:0006468 10 CREB1 CHUK CDK4 CDK2 CCND2
31 cell cycle GO:0007049 10 EP300 CDKN1A CDK4 CDK2 CCND2

Molecular functions related to Human T-Cell Leukemia Virus Type 1 according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.89 NFKB1 JUN GLI2 CREB1 ATF1
2 DNA-binding transcription factor activity GO:0003700 9.77 NFKB1 JUN GLI2 CREB1 ATF1
3 transcription regulatory region DNA binding GO:0044212 9.73 NFKB1 JUN GLI2 CREB1
4 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.65 NFKB1 JUN CREB1
5 transcription coregulator activity GO:0003712 9.63 EP300 CREBBP CREB1
6 chromatin binding GO:0003682 9.63 NFKB1 JUN GLI2 EP300 CRTC2 CREBBP
7 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.62 JUN EP300 CREB1 ATF1
8 acetyltransferase activity GO:0016407 9.54 EP300 CREBBP
9 cAMP response element binding GO:0035497 9.51 JUN CREB1
10 transcription factor binding GO:0008134 9.43 NFKB1 JUN GLI2 EP300 CREBBP CREB1
11 cAMP response element binding protein binding GO:0008140 9.4 CRTC3 CRTC2
12 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.26 CDK4 CDK2
13 RNA polymerase II activating transcription factor binding GO:0001102 8.92 JUN EP300 CREBBP CREB1
14 protein binding GO:0005515 10.37 XPO1 NFKB1 JUN GLI2 EP300 CRTC2

Sources for Human T-Cell Leukemia Virus Type 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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