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MCID: HMN022
MIFTS: 37

Human T-Cell Leukemia Virus Type 2

Categories: Blood diseases, Cancer diseases, Immune diseases, Infectious diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Human T-Cell Leukemia Virus Type 2

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MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 2:

Name: Human T-Cell Leukemia Virus Type 2 52
Human T Lymphotropic Virus Type 2 52
Htlv-2 52

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Infectious diseases
Anatomical: Immune diseases Skin diseases Blood diseases
See all MalaCards categories (disease lists)


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Summaries for Human T-Cell Leukemia Virus Type 2

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NIH Rare Diseases : 52 Human T-cell leukemia virus , type 2 (HTLV-2) is a retroviral infection that affect the T cells (a type of white blood cell ). Although this virus generally causes no signs or symptoms, scientists suspect that some affected people may later develop neurological problems and/or chronic lung infections. HTLV-2 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-2 and it is considered a lifelong condition; however, most infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 2, also known as human t lymphotropic virus type 2, is related to human t-cell leukemia virus type 1 and t-cell lymphoblastic leukemia/lymphoma. An important gene associated with Human T-Cell Leukemia Virus Type 2 is ADAR (Adenosine Deaminase RNA Specific), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and breast, and related phenotypes are Increased TP53 mRNA expression and cellular

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Related Diseases for Human T-Cell Leukemia Virus Type 2

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Diseases in the Adult T-Cell Leukemia family:

Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 human t-cell leukemia virus type 1 30.1 NFKB1 EP300 CREBBP CREB1 CNTN2
2 t-cell lymphoblastic leukemia/lymphoma 29.4 STAT5A NFKB1 HNRNPA1 EP300 CREBBP CREB1
3 human immunodeficiency virus type 1 29.4 STAT1 NFKB1 IFNG ADAR
4 leukemia, t-cell, chronic 10.8
5 adult t-cell leukemia 10.4
6 t-cell adult acute lymphocytic leukemia 10.3
7 thumb deformity 10.3 EP300 CREBBP
8 rubinstein-taybi syndrome 1 10.2 EP300 CREBBP
9 myelopathy, htlv-1-associated 10.2
10 tropical spastic paraparesis 10.2
11 htlv-1 associated myelopathy/tropical spastic paraparesis 10.2
12 spastic paraparesis 10.2
13 hepatitis c virus 10.2
14 polyneuropathy 10.2
15 viral hepatitis 10.2
16 candida glabrata 10.1 IFNG CSF2
17 otopalatodigital syndrome, type i 10.1 EP300 CREBBP CREB1
18 chromosome 16p13.3 deletion syndrome, proximal 10.1 EP300 CREBBP CREB1
19 bacterial sepsis 10.1
20 hairy cell leukemia 10.1
21 meningoencephalitis 10.1
22 leukemia 10.1
23 hepatitis c 10.1
24 astrocytoma 10.1
25 nemaline myopathy 10.1
26 syphilis 10.1
27 myopathy 10.1
28 peripheral nervous system disease 10.1
29 lymphopenia 10.1
30 neuropathy 10.1
31 carotid artery thrombosis 10.0 IFNG CSF2
32 stomatitis 10.0 IFNG CSF2 ADAR
33 monocytic leukemia 9.9 IFNG EP300 CSF2
34 mucormycosis 9.9 IFNG CSF2
35 tetanus 9.9 IFNG CSF2 CREB1
36 sting-associated vasculopathy with onset in infancy 9.9 STAT1 ADAR
37 fungal meningitis 9.8 IFNG CSF2
38 relapsing-remitting multiple sclerosis 9.8 IFNG HNRNPA1 CSF2
39 juvenile myelomonocytic leukemia 9.7 STAT5A CSF2 CREBBP CREB1
40 chronic myelomonocytic leukemia 9.7 STAT5A CSF2 CREBBP
41 campylobacteriosis 9.6 STAT1 IFNG
42 macs syndrome 9.6 STAT1 IFNG
43 opportunistic mycosis 9.5 STAT1 IFNG CSF2
44 fungal infectious disease 9.5 STAT1 IFNG CSF2
45 chronic mucocutaneous candidiasis 9.5 STAT1 IFNG CSF2
46 candidiasis 9.5 STAT1 IFNG CSF2
47 human immunodeficiency virus infectious disease 9.4 STAT1 IFNG CSF2
48 measles 9.4 STAT1 IFNG ADAR
49 polycythemia vera 9.4 STAT5A STAT1 CSF2
50 severe combined immunodeficiency 9.3 STAT5A IFNG EP300 CSF2 CREB1

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 2:



Diseases related to Human T-Cell Leukemia Virus Type 2
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Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 2

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GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased TP53 mRNA expression GR00389-S-5 8.32 NFKB1

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 2:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 ADAR CREB1 CREBBP CSF2 EP300 HGS
2 behavior/neurological MP:0005386 10.21 CNTN2 CREB1 CREBBP CSF2 HGS IFNG
3 growth/size/body region MP:0005378 10.2 ADAR CREB1 CREBBP CSF2 EP300 HGS
4 cardiovascular system MP:0005385 10.15 ADAR CREB1 CREBBP CSF2 EP300 HGS
5 mortality/aging MP:0010768 10.11 ADAR CREB1 CREBBP CSF2 EP300 HGS
6 embryo MP:0005380 10.1 ADAR CREB1 CREBBP CSF2 EP300 HGS
7 endocrine/exocrine gland MP:0005379 10.08 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
8 nervous system MP:0003631 10.03 ADAR CNTN2 CREB1 CREBBP CSF2 EP300
9 craniofacial MP:0005382 10 CREBBP CSF2 EP300 IFNG NFKB1 PTBP1
10 digestive/alimentary MP:0005381 9.99 CREBBP EP300 HGS IFNG NFKB1 STAT1
11 integument MP:0010771 9.98 ADAR CREBBP CSF2 IFNG NFKB1 STAT1
12 liver/biliary system MP:0005370 9.88 ADAR CREBBP IFNG NFKB1 STAT1 STAT5A
13 muscle MP:0005369 9.87 CREB1 CREBBP EP300 HGS IFNG NFKB1
14 normal MP:0002873 9.7 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
15 respiratory system MP:0005388 9.5 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
16 skeleton MP:0005390 9.28 ADAR CREB1 CREBBP CSF2 HGS IFNG
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Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 2

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Drugs for Human T-Cell Leukemia Virus Type 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Extended Dose - Total Body Irradiation Followed By Allogeneic Stem Cell Transplantation For The Treatment Of Refractory Acute Leukemia And Advanced Myelodysplastic Syndrome Suspended NCT01709396 Phase 2
2 Human OK99 Allogeneic Stem Cell Transplantation for Patients With Severe Parkinson's Disease Unknown status NCT02780895 Phase 1 Human Stem Cells
3 Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP) Recruiting NCT00001778
4 Electromiography Study in the Respiratory Muscle Training in Human Lymphotropic Virus Type 1 Recruiting NCT03829709
5 A Prospective Study of Transfusion-Transmitted Infections Recruiting NCT00023023
6 Epidemiological and Molecular Aspects of the Interspecies Transmission of Foamy Viruses From Monkeys to Humans: A Model of the Early Stages of Viral Emergence. Recruiting NCT03225794

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 2

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Genetic Tests for Human T-Cell Leukemia Virus Type 2

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Anatomical Context for Human T-Cell Leukemia Virus Type 2

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MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 2:

40
T Cells, Lung, Breast, Testes, Monocytes
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Publications for Human T-Cell Leukemia Virus Type 2

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Articles related to Human T-Cell Leukemia Virus Type 2:

(show top 50) (show all 62)
# Title Authors PMID Year
1
The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication. 61
31597781 2019
2
Human T-cell Leukemia Virus Type 2: Still Rare in Japan. 61
31625372 2019
3
Comparative virology of HTLV-1 and HTLV-2. 61
31391116 2019
4
Comparative performances of serologic and molecular assays for detecting human T lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) in patients infected with human immunodeficiency virus type 1 (HIV-1). 61
28343818 2017
5
Brief Report: Reduced Cell-Associated HTLV-2 DNA in Antiretroviral Treated HIV-1-HCV-Coinfected Patients Who Either Received Interferon-α/Ribavirin-Based Hepatitis C Therapy or Had Spontaneous HCV RNA Clearance. 61
26181704 2015
6
Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in São Paulo, Brazil. 61
25464979 2015
7
Human T-lymphotropic virus type 2 subtype b in a patient with chronic neurological disorder. 61
25183319 2014
8
Developing an in vitro model of T cell type of large granular lymphocyte leukemia. 61
24183305 2013
9
Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 Tax proteins in vitro. 61
23464580 2013
10
Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation? 61
23730325 2013
11
Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells. 61
23054433 2013
12
Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2. 61
23286582 2013
13
Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. 61
23135727 2013
14
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1. 61
22993189 2012
15
Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo. 61
22623800 2012
16
HTLV-2B strains, similar to those found in several Amerindian tribes, are endemic in central African Bakola Pygmies. 61
21459818 2011
17
Long terminal repeat sequence analysis of HTLV-2 molecular variants identified in Southern Brazil. 61
20939687 2010
18
High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection. 61
19657093 2009
19
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription. 61
19602711 2009
20
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo. 61
19553333 2009
21
Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication. 61
19279097 2009
22
Neurological aspects of HIV/human T lymphotropic virus coinfection. 61
19529747 2009
23
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo. 61
18474092 2008
24
Human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in an HIV-positive patient coinfected with human T lymphotropic virus type 2 following initiation of antiretroviral therapy. 61
17918071 2007
25
Difficulties in the diagnosis of HTLV-2 infection in HIV/AIDS patients from Brazil: comparative performances of serologic and molecular assays, and detection of HTLV-2b subtype. 61
17823751 2007
26
Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line. 61
17140451 2006
27
Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y. 61
16908858 2006
28
Functional analysis of human T lymphotropic virus type 2 Tax proteins. 61
16551350 2006
29
Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus. 61
16140768 2005
30
Prevalence and molecular characterization of human T cell leukemia virus type 2 in a group of intravenous drug users coinfected with HIV type 1 in Portugal. 61
15943566 2005
31
Growth and manipulation of a human T-cell leukemia virus type 2 full-length molecular clone. 61
16061993 2005
32
Isolation and confirmation of human T-cell leukemia virus type 2 from peripheral blood mononuclear cells. 61
16061970 2005
33
Utilization of the CBP but not the p300 co-activator by human T-lymphotropic virus type-2 Tax for p53 inhibition. 61
15156194 2004
34
The MHC class II transcriptional activator (CIITA) inhibits HTLV-2 viral replication by blocking the function of the viral transactivator Tax-2. 61
14525769 2004
35
Functional domain structure of human T-cell leukemia virus type 2 rex. 61
14610204 2003
36
Complete nucleotide sequences of the genomes of two Brazilian specimens of human T lymphotropic virus type 2 (HTLV-2). 61
13678471 2003
37
Divergent simian T-cell lymphotropic virus type 3 (STLV-3) in wild-caught Papio hamadryas papio from Senegal: widespread distribution of STLV-3 in Africa. 61
12477886 2003
38
Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. 61
12370379 2002
39
A comparative study of the human T-cell leukemia virus type 2 integrase expressed in and purified from Escherichia coli and Pichia pastoris. 61
12135562 2002
40
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. 61
11861831 2002
41
Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. 61
11756175 2002
42
Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function. 61
11507189 2001
43
Molecular characterization and phylogenetic analysis of a human T cell leukemia virus type 2 strain from French Guiana. 61
11350670 2001
44
Resistance to Fas-mediated apoptosis of human T-cell lines expressing human T-lymphotropic virus type-2 (HTLV-2) Tax protein. 61
11222094 2001
45
In vitro cellular tropism of human T cell leukemia virus type 2. 61
11080807 2000
46
Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. 61
10684280 2000
47
Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs. 61
10482560 1999
48
Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy. 61
9696872 1998
49
African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies. 61
9557723 1998
50
Identification of a domain within the human T-cell leukemia virus type 2 envelope required for syncytium induction and replication. 61
9499049 1998
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Variations for Human T-Cell Leukemia Virus Type 2

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Expression for Human T-Cell Leukemia Virus Type 2

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Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 2.
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Pathways for Human T-Cell Leukemia Virus Type 2

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Pathways related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.11 STAT5A STAT1 PTBP1 NFKB1 HNRNPA1 HGS
2
Innate Immune System 65
Show member pathways
 13.98 STAT5A STAT1 NFKB1 IFNG EP300 CSF2
3
ERK Signaling 63
Show member pathways
 13.78 STAT5A STAT1 NFKB1 EP300 CSF2 CREBBP
4
HIV Life Cycle 65
Show member pathways
 13.67 STAT5A STAT1 NFKB1 HGS EP300 CREBBP
5
PEDF Induced Signaling 63
Show member pathways
 13.64 STAT5A NFKB1 IFNG EP300 CSF2 CREBBP
6
TGF-Beta Pathway 63
Show member pathways
 13.49 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
7
Developmental Biology 65
Show member pathways
 13.45 NFKB1 EP300 CSF2 CREBBP CREB1 CNTN2
8
Cytokine Signaling in Immune system 65
Show member pathways
 13.33 STAT5A STAT1 NFKB1 IFNG CSF2 ADAR
9
IL-2 Pathway 63
Show member pathways
 13.14 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
10
PI3K-Akt signaling pathway 36
Show member pathways
 12.96 STAT1 NFKB1 EP300 CREBBP CREB1
11
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.96 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
12
Human cytomegalovirus infection 36
Show member pathways
 12.87 STAT1 NFKB1 EP300 CSF2 CREBBP CREB1
13
CCR5 Pathway in Macrophages 63
Show member pathways
 12.85 STAT5A STAT1 NFKB1 EP300 CREBBP
14
Pathways in cancer 36
12.76 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
15
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.74 STAT5A STAT1 NFKB1 CREB1
16
Endometrial cancer 36
Show member pathways
 12.72 STAT5A STAT1 NFKB1 EP300 CSF2 CREBBP
17
nNOS Signaling in Skeletal Muscle 63
Show member pathways
 12.65 NFKB1 EP300 CREBBP CREB1
18
4-1BB Pathway 63
Show member pathways
 12.62 STAT1 NFKB1 IFNG CREBBP CREB1
19
Measles 36
Show member pathways
 12.62 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
20
Th17 cell differentiation 36
Show member pathways
 12.58 STAT5A STAT1 NFKB1 IFNG
21
Immune response IL-23 signaling pathway 22
Show member pathways
 12.58 STAT5A STAT1 NFKB1 IFNG
22
ErbB signaling pathway 36 1
Show member pathways
 12.58 STAT5A STAT1 NFKB1 EP300 CREBBP
23
Relaxin signaling pathway 36
Show member pathways
 12.58 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
24
T cell receptor signaling pathway 36
Show member pathways
 12.56 STAT1 NFKB1 IFNG CSF2 CREB1
25
NF-kappaB Signaling 4
12.55 STAT5A STAT1 NFKB1 IFNG
26
Cytosolic sensors of pathogen-associated DNA 65
Show member pathways
 12.54 NFKB1 EP300 CREBBP ADAR
27
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.53 NFKB1 IFNG EP300 CREBBP
28
JAK-STAT signaling pathway 36
Show member pathways
 12.37 STAT5A STAT1 IFNG EP300 CSF2 CREBBP
29
Development IGF-1 receptor signaling 22
Show member pathways
 12.33 STAT5A STAT1 NFKB1 EP300 CREB1
30
Prolactin Signaling Pathway 36 1
Show member pathways
 12.33 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
31
CNTF Signaling 63
Show member pathways
 12.32 STAT5A STAT1 NFKB1 CREB1
32
cAMP signaling pathway 36
12.32 NFKB1 EP300 CREBBP CREB1
33
Toll Comparative Pathway 63
Show member pathways
 12.26 STAT1 NFKB1 IFNG EP300 CREB1
34
Viral carcinogenesis 36
12.24 STAT5A NFKB1 EP300 CREBBP CREB1
35
C-type lectin receptor signaling pathway 36
Show member pathways
 12.2 STAT1 NFKB1 EP300 CREBBP
36
Necroptosis 36
Show member pathways
 12.18 STAT5A STAT1 IFNG
37
Development NOTCH1-mediated pathway for NF-KB activity modulation 22
Show member pathways
 12.18 NFKB1 EP300 CREBBP
38
EGF/EGFR Signaling Pathway 1
12.17 STAT5A STAT1 HGS CREB1
39
Colorectal Cancer Metastasis 63
12.16 STAT1 NFKB1 IFNG
40
Bacterial infections in CF airways 22
Show member pathways
 12.16 STAT1 NFKB1 IFNG
41
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.16 NFKB1 EP300 CREBBP CREB1
42
Kit receptor signaling pathway 1
Show member pathways
 12.15 STAT5A STAT1 EP300 CREBBP
43
Human T-cell leukemia virus 1 infection 36
12.14 STAT5A NFKB1 EP300 CSF2 CREBBP CREB1
44
Integrated Breast Cancer Pathway 1
12.13 STAT1 NFKB1 EP300 CREB1
45
NGF Pathway 63
Show member pathways
 12.12 NFKB1 CREBBP CREB1
46
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
12.09 STAT5A STAT1 NFKB1 CREB1
47
IL-2 Signaling Pathway 1
Show member pathways
 12.06 STAT5A STAT1 IFNG
48
TGF-beta Signaling Pathway (WikiPathways) 1
12.05 HGS EP300 CREBBP
49
Adipogenesis 1
12.05 STAT5A STAT1 CREB1
50
Osteoclast differentiation 36
12.02 STAT1 NFKB1 IFNG CREB1
Sources

GO Terms for Human T-Cell Leukemia Virus Type 2

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Cellular components related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.35 STAT5A STAT1 NFKB1 CREBBP CREB1
2 nucleoplasm GO:0005654 9.28 STAT5A STAT1 PTBP1 NFKB1 HNRNPA1 EP300

Biological processes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.08 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 STAT1 NFKB1 IFNG EP300 CREBBP
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
4 positive regulation of gene expression GO:0010628 9.91 IFNG HGS EP300 CSF2
5 positive regulation of transcription, DNA-templated GO:0045893 9.85 STAT1 NFKB1 EP300 CREBBP CREB1
6 viral process GO:0016032 9.8 STAT1 HNRNPA1 EP300 CREBBP CREB1
7 rhythmic process GO:0048511 9.76 EP300 CREBBP CREB1
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.7 NFKB1 EP300 CREBBP
9 positive regulation of osteoclast differentiation GO:0045672 9.6 IFNG CREB1
10 macrophage differentiation GO:0030225 9.59 IFNG CSF2
11 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.57 NFKB1 CSF2
12 positive regulation of exosomal secretion GO:1903543 9.56 IFNG HGS
13 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.55 STAT1 IFNG
14 protein acetylation GO:0006473 9.54 EP300 CREBBP
15 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.51 STAT1 IFNG
16 regulation of myeloid cell differentiation GO:0045637 9.49 CSF2 CREBBP
17 interleukin-9-mediated signaling pathway GO:0038113 9.43 STAT5A STAT1
18 positive regulation of type I interferon production GO:0032481 9.43 NFKB1 EP300 CREBBP
19 macrophage derived foam cell differentiation GO:0010742 9.37 STAT1 EP300
20 positive regulation of interleukin-23 production GO:0032747 9.32 IFNG CSF2
21 N-terminal peptidyl-lysine acetylation GO:0018076 9.16 EP300 CREBBP
22 JAK-STAT cascade GO:0007259 9.13 STAT5A STAT1 IFNG
23 positive regulation of transcription of Notch receptor target GO:0007221 8.8 STAT1 EP300 CREBBP

Molecular functions related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.07 STAT5A STAT1 PTBP1 NFKB1 IFNG HNRNPA1
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.76 STAT5A STAT1 NFKB1 CREB1
3 transcription factor binding GO:0008134 9.71 NFKB1 EP300 CREBBP CREB1
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.55 STAT5A STAT1 NFKB1 EP300 CREB1
5 transcription coregulator activity GO:0003712 9.54 EP300 CREBBP CREB1
6 nuclear hormone receptor binding GO:0035257 9.49 STAT1 EP300
7 ubiquitin-like protein ligase binding GO:0044389 9.48 STAT1 HGS
8 acetyltransferase activity GO:0016407 9.43 EP300 CREBBP
9 pre-mRNA binding GO:0036002 9.32 PTBP1 HNRNPA1
10 peptide-lysine-N-acetyltransferase activity GO:0061733 8.96 EP300 CREBBP
11 RNA polymerase II activating transcription factor binding GO:0001102 8.8 EP300 CREBBP CREB1
Sources

Sources for Human T-Cell Leukemia Virus Type 2

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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