MCID: HMN022
MIFTS: 43

Human T-Cell Leukemia Virus Type 2

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Human T-Cell Leukemia Virus Type 2

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 2:

Name: Human T-Cell Leukemia Virus Type 2 54
Human T Lymphotropic Virus Type 2 54
Htlv-2 54

Classifications:



Summaries for Human T-Cell Leukemia Virus Type 2

NIH Rare Diseases : 54 Human T-cell leukemia virus, type 2 (HTLV-2) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, scientists suspect that some affected people may later develop neurological problems and/or chronic lung infections. HTLV-2 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-2 and it is considered a lifelong condition; however, most infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 2, also known as human t lymphotropic virus type 2, is related to tropical spastic paraparesis and t-cell leukemia. An important gene associated with Human T-Cell Leukemia Virus Type 2 is IFNG (Interferon Gamma), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and breast, and related phenotypes are Decreased TP53 mRNA expression and cellular

Related Diseases for Human T-Cell Leukemia Virus Type 2

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 30.0 CNTN2 IFNG NFKB1
2 t-cell leukemia 29.9 CNTN2 CREB1 CREBBP EP300 NFKB1 STAT5A
3 human t-cell leukemia virus type 1 29.9 CNTN2 CREB1 CREBBP EP300 NFKB1
4 human immunodeficiency virus type 1 29.7 ADAR IFNG NFKB1 STAT1
5 leukemia 10.8
6 large granular lymphocyte leukemia 10.3 CSF2 IFNG
7 trichosporonosis 10.3 CSF2 IFNG
8 mucormycosis 10.3 CSF2 IFNG
9 candida glabrata 10.2 CSF2 IFNG
10 carotid artery thrombosis 10.2 CSF2 IFNG
11 meconium aspiration syndrome 10.2 CSF2 IFNG
12 cyclic neutropenia 10.1 CSF2 IFNG
13 polyneuropathy 10.1
14 rubinstein-taybi syndrome 1 10.1 CREBBP EP300
15 cytomegalovirus retinitis 10.1 CSF2 IFNG
16 myelopathy, htlv-1-associated 10.1
17 spastic paraparesis 10.1
18 campylobacteriosis 10.0 IFNG STAT1
19 neonatal leukemia 10.0 CREBBP EP300
20 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0
21 hepatitis 10.0
22 hepatitis b 10.0
23 viral hepatitis 10.0
24 myopathy 10.0
25 peripheral nervous system disease 10.0
26 neuropathy 10.0
27 chromosome 16p13.3 deletion syndrome, proximal 10.0 CREB1 CREBBP EP300
28 measles 9.9 ADAR IFNG STAT1
29 hematologic cancer 9.7 CREBBP CSF2 EP300 STAT5A
30 leukemia, chronic myeloid 9.4 CSF2 STAT1 STAT5A

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 2:



Diseases related to Human T-Cell Leukemia Virus Type 2

Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 2

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.62 CREB1 NFKB1

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 2:

47 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 ADAR CREB1 CREBBP CSF2 EP300 IFNG
2 growth/size/body region MP:0005378 10.22 ADAR CREB1 CREBBP CSF2 EP300 IFNG
3 behavior/neurological MP:0005386 10.19 CNTN2 CREB1 CREBBP CSF2 IFNG NFKB1
4 homeostasis/metabolism MP:0005376 10.15 ADAR CREB1 CREBBP CSF2 EP300 IFNG
5 endocrine/exocrine gland MP:0005379 10.14 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
6 cardiovascular system MP:0005385 10.12 ADAR CREB1 CREBBP CSF2 EP300 IFNG
7 hematopoietic system MP:0005397 10.11 ADAR CREBBP CSF2 EP300 IFNG NFKB1
8 mortality/aging MP:0010768 10.1 ADAR CREB1 CREBBP CSF2 EP300 IFNG
9 embryo MP:0005380 10.09 ADAR CREB1 CREBBP CSF2 EP300 IFNG
10 immune system MP:0005387 10.08 ADAR CREBBP CSF2 EP300 IFNG NFKB1
11 craniofacial MP:0005382 10.03 CREBBP CSF2 EP300 IFNG NFKB1 PTBP1
12 integument MP:0010771 10 ADAR CREBBP CSF2 IFNG NFKB1 STAT1
13 nervous system MP:0003631 9.96 ADAR CNTN2 CREB1 CREBBP CSF2 EP300
14 liver/biliary system MP:0005370 9.91 ADAR CREBBP IFNG NFKB1 STAT1 STAT5A
15 muscle MP:0005369 9.85 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
16 neoplasm MP:0002006 9.72 CREBBP CSF2 EP300 IFNG STAT1
17 normal MP:0002873 9.7 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
18 respiratory system MP:0005388 9.43 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
19 skeleton MP:0005390 9.23 ADAR CREB1 CREBBP CSF2 IFNG NFKB1

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 2

Drugs for Human T-Cell Leukemia Virus Type 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
2 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
3 Retrovirus Epidemiology Donor Study I (REDS I) Completed NCT00005278
4 Dual Algorithm Post Market Clinical Study Completed NCT03146013
5 Evaluation of InnoLIA HTLV I/II Score Completed NCT01149837
6 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 2

Genetic Tests for Human T-Cell Leukemia Virus Type 2

Anatomical Context for Human T-Cell Leukemia Virus Type 2

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 2:

42
T Cells, Lung, Breast, Monocytes

Publications for Human T-Cell Leukemia Virus Type 2

Articles related to Human T-Cell Leukemia Virus Type 2:

(show all 39)
# Title Authors Year
1
Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in São Paulo, Brazil. ( 25464979 )
2015
2
Human T-lymphotropic virus type 2 subtype b in a patient with chronic neurological disorder. ( 25183319 )
2014
3
Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells. ( 23054433 )
2013
4
Human T cell leukemia virus type 2 tax-mediated NF-I_B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. ( 23135727 )
2013
5
Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-I_B activation? ( 23730325 )
2013
6
Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2. ( 23286582 )
2013
7
Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo. ( 22623800 )
2012
8
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1. ( 22993189 )
2012
9
Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication. ( 19279097 )
2009
10
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription. ( 19602711 )
2009
11
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo. ( 19553333 )
2009
12
High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection. ( 19657093 )
2009
13
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo. ( 18474092 )
2008
14
Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line. ( 17140451 )
2006
15
Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y. ( 16908858 )
2006
16
Growth and manipulation of a human T-cell leukemia virus type 2 full-length molecular clone. ( 16061993 )
2005
17
Isolation and confirmation of human T-cell leukemia virus type 2 from peripheral blood mononuclear cells. ( 16061970 )
2005
18
Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus. ( 16140768 )
2005
19
Prevalence and molecular characterization of human T cell leukemia virus type 2 in a group of intravenous drug users coinfected with HIV type 1 in Portugal. ( 15943566 )
2005
20
Functional domain structure of human T-cell leukemia virus type 2 rex. ( 14610204 )
2003
21
Complete nucleotide sequences of the genomes of two Brazilian specimens of human T lymphotropic virus type 2 (HTLV-2). ( 13678471 )
2003
22
Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. ( 11756175 )
2002
23
A comparative study of the human T-cell leukemia virus type 2 integrase expressed in and purified from Escherichia coli and Pichia pastoris. ( 12135562 )
2002
24
Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. ( 12370379 )
2002
25
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. ( 11861831 )
2002
26
Molecular characterization and phylogenetic analysis of a human T cell leukemia virus type 2 strain from French Guiana. ( 11350670 )
2001
27
Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function. ( 11507189 )
2001
28
Resistance to Fas-mediated apoptosis of human T-cell lines expressing human T-lymphotropic virus type-2 (HTLV-2) Tax protein. ( 11222094 )
2001
29
In vitro cellular tropism of human T cell leukemia virus type 2. ( 11080807 )
2000
30
Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. ( 10684280 )
2000
31
Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs. ( 10482560 )
1999
32
Identification of a domain within the human T-cell leukemia virus type 2 envelope required for syncytium induction and replication. ( 9499049 )
1998
33
Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy. ( 9696872 )
1998
34
Mutational analysis of human T-cell leukemia virus type 2 Tax. ( 9343258 )
1997
35
Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs. ( 9060636 )
1997
36
The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes. ( 8764028 )
1996
37
Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation. ( 8764063 )
1996
38
Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements. ( 7474099 )
1995
39
Translation of gag, pro, and pol gene products of human T-cell leukemia virus type 2. ( 2467996 )
1989

Variations for Human T-Cell Leukemia Virus Type 2

Expression for Human T-Cell Leukemia Virus Type 2

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 2.

Pathways for Human T-Cell Leukemia Virus Type 2

Pathways related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 CREB1 CREBBP CSF2 EP300 HNRNPA1 NFKB1
2
Show member pathways
13.95 ADAR CREB1 CREBBP CSF2 EP300 IFNG
3
Show member pathways
13.62 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
4
Show member pathways
13.48 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
5
Show member pathways
13.44 CNTN2 CREB1 CREBBP CSF2 EP300 NFKB1
6
Show member pathways
13.31 ADAR CSF2 IFNG NFKB1 STAT1 STAT5A
7
Show member pathways
13.12 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
8
Show member pathways
12.95 CREB1 CREBBP EP300 NFKB1 STAT1
9
Show member pathways
12.85 CREBBP EP300 NFKB1 STAT1 STAT5A
10
Show member pathways
12.83 CREB1 CREBBP CSF2 EP300 NFKB1 STAT1
11
Show member pathways
12.82 CREB1 CREBBP EP300 NFKB1
12 12.75 CREBBP EP300 IFNG NFKB1 STAT1 STAT5A
13
Show member pathways
12.73 CREB1 NFKB1 STAT1 STAT5A
14
Show member pathways
12.72 ADAR CREBBP EP300 IFNG NFKB1
15
Show member pathways
12.72 CREB1 CREBBP CSF2 EP300 NFKB1 STAT1
16
Show member pathways
12.64 CREB1 CREBBP IFNG NFKB1 STAT1
17
Show member pathways
12.57 IFNG NFKB1 STAT1 STAT5A
18
Show member pathways
12.57 IFNG NFKB1 STAT1 STAT5A
19 12.54 IFNG NFKB1 STAT1 STAT5A
20
Show member pathways
12.53 CREBBP EP300 NFKB1 STAT1 STAT5A
21
Show member pathways
12.47 CREB1 CREBBP EP300 NFKB1
22
Show member pathways
12.41 CREB1 CSF2 IFNG NFKB1
23
Show member pathways
12.35 ADAR CREBBP EP300 IFNG NFKB1 STAT1
24
Show member pathways
12.33 CREB1 CREBBP EP300 NFKB1 STAT1 STAT5A
25
Show member pathways
12.32 CREB1 NFKB1 STAT1 STAT5A
26
Show member pathways
12.32 CREB1 EP300 NFKB1 STAT1 STAT5A
27
Show member pathways
12.3 CREBBP CSF2 EP300 IFNG STAT1 STAT5A
28 12.29 CREB1 CREBBP EP300 NFKB1
29
Show member pathways
12.25 CREB1 EP300 IFNG NFKB1 STAT1
30 12.24 ADAR HNRNPA1 PTBP1
31
Show member pathways
12.23 CREB1 IFNG NFKB1 STAT1 STAT5A
32
Show member pathways
12.22 IFNG NFKB1 STAT1
33 12.21 CREB1 CREBBP EP300 NFKB1 STAT5A
34
Show member pathways
12.2 CREB1 CREBBP EP300
35
Show member pathways
12.19 CREBBP EP300 NFKB1 STAT1
36 12.19 CREB1 CREBBP CSF2 EP300 NFKB1 STAT5A
37
Show member pathways
12.18 IFNG STAT1 STAT5A
38
Show member pathways
12.17 CREBBP EP300 NFKB1
39
Show member pathways
12.16 CREB1 CREBBP EP300
40
Show member pathways
12.16 IFNG NFKB1 STAT1
41 12.16 IFNG NFKB1 STAT1
42 12.15 CREB1 STAT1 STAT5A
43 12.15 CREB1 CREBBP EP300 NFKB1
44
Show member pathways
12.14 CREBBP EP300 STAT1 STAT5A
45
Show member pathways
12.11 CREB1 CREBBP NFKB1
46 12.11 CREB1 EP300 NFKB1 STAT1
47 12.07 CREB1 NFKB1 STAT1 STAT5A
48
Show member pathways
12.05 IFNG STAT1 STAT5A
49
Show member pathways
12.05 CREBBP EP300 IFNG STAT1
50 12.04 CREB1 STAT1 STAT5A

GO Terms for Human T-Cell Leukemia Virus Type 2

Cellular components related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 ADAR CREB1 CREBBP EP300 HNRNPA1 NFKB1
2 histone acetyltransferase complex GO:0000123 8.96 CREBBP EP300

Biological processes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.92 CREBBP EP300 IFNG NFKB1 STAT1
2 positive regulation of transcription, DNA-templated GO:0045893 9.83 CREB1 CREBBP EP300 NFKB1 STAT1
3 defense response to virus GO:0051607 9.79 ADAR IFNG STAT1
4 response to hypoxia GO:0001666 9.75 CREB1 CREBBP EP300
5 rhythmic process GO:0048511 9.71 CREB1 CREBBP EP300
6 viral process GO:0016032 9.65 CREB1 CREBBP EP300 HNRNPA1 STAT1
7 beta-catenin-TCF complex assembly GO:1904837 9.61 CREBBP EP300
8 positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 9.6 CREBBP EP300
9 JAK-STAT cascade GO:0007259 9.59 STAT1 STAT5A
10 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.58 CREBBP EP300
11 positive regulation of osteoclast differentiation GO:0045672 9.57 CREB1 IFNG
12 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.55 CSF2 NFKB1
13 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 CREBBP EP300 NFKB1
14 protein acetylation GO:0006473 9.51 CREBBP EP300
15 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 IFNG STAT1
16 regulation of myeloid cell differentiation GO:0045637 9.48 CREBBP CSF2
17 interleukin-9-mediated signaling pathway GO:0038113 9.46 STAT1 STAT5A
18 macrophage derived foam cell differentiation GO:0010742 9.4 EP300 STAT1
19 positive regulation of interleukin-23 production GO:0032747 9.32 CSF2 IFNG
20 N-terminal peptidyl-lysine acetylation GO:0018076 9.16 CREBBP EP300
21 positive regulation of type I interferon production GO:0032481 9.13 CREBBP EP300 NFKB1
22 positive regulation of transcription of Notch receptor target GO:0007221 8.8 CREBBP EP300 STAT1
23 regulation of transcription, DNA-templated GO:0006355 10.03 CREB1 CREBBP EP300 NFKB1 STAT1 STAT5A

Molecular functions related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.67 CREB1 NFKB1 STAT1 STAT5A
2 transcription factor binding GO:0008134 9.56 CREB1 CREBBP EP300 NFKB1
3 histone acetyltransferase binding GO:0035035 9.46 CREB1 STAT1
4 nuclear hormone receptor binding GO:0035257 9.43 EP300 STAT1
5 acetyltransferase activity GO:0016407 9.4 CREBBP EP300
6 transcription coregulator activity GO:0003712 9.33 CREB1 CREBBP EP300
7 pre-mRNA binding GO:0036002 9.32 HNRNPA1 PTBP1
8 RNA polymerase II activating transcription factor binding GO:0001102 9.13 CREB1 CREBBP EP300
9 peptide N-acetyltransferase activity GO:0034212 8.62 CREBBP EP300

Sources for Human T-Cell Leukemia Virus Type 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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