MCID: HMN022
MIFTS: 34

Human T-Cell Leukemia Virus Type 2

Categories: Blood diseases, Cancer diseases, Immune diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Human T-Cell Leukemia Virus Type 2

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 2:

Name: Human T-Cell Leukemia Virus Type 2 20
Human T Lymphotropic Virus Type 2 20
Htlv-2 20

Classifications:



Summaries for Human T-Cell Leukemia Virus Type 2

GARD : 20 Human T- cell leukemia virus, type 2 (HTLV-2) is a retroviral infection that affect the T cells (a type of white blood cell ). Although this virus generally causes no signs or symptoms, scientists suspect that some affected people may later develop neurological problems and/or chronic lung infections. HTLV-2 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-2 and it is considered a lifelong condition; however, most infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 2, also known as human t lymphotropic virus type 2, is related to human t-cell leukemia virus type 1 and t-cell lymphoblastic leukemia/lymphoma. An important gene associated with Human T-Cell Leukemia Virus Type 2 is ADAR (Adenosine Deaminase RNA Specific), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. Affiliated tissues include t cells, myeloid and skin, and related phenotypes are Increased TP53 mRNA expression and cellular

Related Diseases for Human T-Cell Leukemia Virus Type 2

Diseases in the Adult T-Cell Leukemia family:

Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 human t-cell leukemia virus type 1 30.5 NFKB1 EP300 CREBBP CREB1 CNTN2
2 t-cell lymphoblastic leukemia/lymphoma 30.1 STAT5A NFKB1 HNRNPA1 EP300 CREBBP CREB1
3 human immunodeficiency virus type 1 29.4 STAT1 NFKB1 IFNG ADAR
4 immune deficiency disease 28.6 STAT5A STAT1 IFNG HNRNPA1 CSF2 CNTN2
5 leukemia, t-cell, chronic 10.9
6 adult t-cell leukemia 10.5
7 myelopathy, htlv-1-associated 10.3
8 tropical spastic paraparesis 10.3
9 htlv-1 associated myelopathy/tropical spastic paraparesis 10.3
10 spastic paraparesis 10.3
11 menke-hennekam syndrome 10.2 EP300 CREBBP
12 thumb deformity 10.2 EP300 CREBBP
13 rubinstein-taybi syndrome 1 10.2 EP300 CREBBP
14 bacterial sepsis 10.2
15 hairy cell leukemia 10.2
16 atrophoderma vermiculata 10.1 IFNG CSF2
17 candida glabrata 10.1 IFNG CSF2
18 otopalatodigital syndrome, type i 10.1 EP300 CREBBP CREB1
19 chromosome 16p13.3 deletion syndrome, proximal 10.1 EP300 CREBBP CREB1
20 t-cell adult acute lymphocytic leukemia 10.1
21 carotid artery thrombosis 10.1 IFNG CSF2
22 mucormycosis 10.1 IFNG CSF2
23 fungal meningitis 10.0 IFNG CSF2
24 hypoxia 10.0 EP300 CREBBP CREB1
25 stomatitis 10.0 IFNG CSF2 ADAR
26 hepatitis c 10.0
27 monocytic leukemia 10.0 IFNG EP300 CSF2
28 tetanus 10.0 IFNG CSF2 CREB1
29 gliosarcoma 9.9 IFNG CSF2 CREBBP
30 hepatitis c virus 9.9
31 polyneuropathy 9.9
32 viral hepatitis 9.9
33 hepatitis b 9.9
34 peripheral nervous system disease 9.9
35 neuropathy 9.9
36 sting-associated vasculopathy with onset in infancy 9.9 STAT1 ADAR
37 relapsing-remitting multiple sclerosis 9.9 IFNG HNRNPA1 CSF2
38 immunodeficiency 27a 9.9 STAT1 IFNG
39 campylobacteriosis 9.8 STAT1 IFNG
40 juvenile myelomonocytic leukemia 9.8 STAT5A CSF2 CREBBP CREB1
41 chronic myelomonocytic leukemia 9.8 STAT5A CSF2 CREBBP
42 fibrosis of extraocular muscles, congenital, 1 9.8
43 glioma susceptibility 1 9.8
44 sickle cell anemia 9.8
45 meningoencephalitis 9.8
46 hepatitis 9.8
47 nemaline myopathy 9.8
48 syphilis 9.8
49 myopathy 9.8
50 lymphopenia 9.8

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 2:



Diseases related to Human T-Cell Leukemia Virus Type 2

Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 2

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased TP53 mRNA expression GR00389-S-5 8.32 NFKB1

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 2:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 ADAR CREB1 CREBBP CSF2 EP300 HGS
2 growth/size/body region MP:0005378 10.17 ADAR CREB1 CREBBP CSF2 EP300 HGS
3 cardiovascular system MP:0005385 10.14 ADAR CREB1 CREBBP CSF2 EP300 HGS
4 mortality/aging MP:0010768 10.11 ADAR CREB1 CREBBP CSF2 EP300 HGS
5 embryo MP:0005380 10.08 ADAR CREB1 CREBBP CSF2 EP300 HGS
6 endocrine/exocrine gland MP:0005379 10.06 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
7 nervous system MP:0003631 10.03 ADAR CNTN2 CREB1 CREBBP CSF2 EP300
8 craniofacial MP:0005382 9.99 CREBBP CSF2 EP300 IFNG NFKB1 PTBP1
9 digestive/alimentary MP:0005381 9.97 CREBBP EP300 HGS IFNG NFKB1 STAT1
10 liver/biliary system MP:0005370 9.88 ADAR CREBBP IFNG NFKB1 STAT1 STAT5A
11 muscle MP:0005369 9.87 CREB1 CREBBP EP300 HGS IFNG NFKB1
12 normal MP:0002873 9.7 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
13 respiratory system MP:0005388 9.5 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
14 skeleton MP:0005390 9.28 ADAR CREB1 CREBBP CSF2 HGS IFNG

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 2

Search Clinical Trials , NIH Clinical Center for Human T-Cell Leukemia Virus Type 2

Genetic Tests for Human T-Cell Leukemia Virus Type 2

Anatomical Context for Human T-Cell Leukemia Virus Type 2

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 2:

40
T Cells, Myeloid, Skin

Publications for Human T-Cell Leukemia Virus Type 2

Articles related to Human T-Cell Leukemia Virus Type 2:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Clinical Outcome in Human T-Lymphotropic Virus Type 2 Carriers Following Organ Transplantation. 61
32921433 2021
2
First case of molecularly identified and genetically characterized human T-cell leukemia virus type 2 infection in a pregnant woman in non-endemic Japan. 61
33098958 2021
3
The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication. 61
31597781 2019
4
Human T-cell Leukemia Virus Type 2: Still Rare in Japan. 61
31625372 2019
5
Comparative virology of HTLV-1 and HTLV-2. 61
31391116 2019
6
Comparative performances of serologic and molecular assays for detecting human T lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) in patients infected with human immunodeficiency virus type 1 (HIV-1). 61
28343818 2017
7
Brief Report: Reduced Cell-Associated HTLV-2 DNA in Antiretroviral Treated HIV-1-HCV-Coinfected Patients Who Either Received Interferon-α/Ribavirin-Based Hepatitis C Therapy or Had Spontaneous HCV RNA Clearance. 61
26181704 2015
8
Short Communication: Current Prevalence and Risk Factors Associated with Human T Lymphotropic Virus Type 1 and Human T Lymphotropic Virus Type 2 Infections Among HIV/AIDS Patients in São Paulo, Brazil. 61
25464979 2015
9
Human T-lymphotropic virus type 2 subtype b in a patient with chronic neurological disorder. 61
25183319 2014
10
Developing an in vitro model of T cell type of large granular lymphocyte leukemia. 61
24183305 2013
11
Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 Tax proteins in vitro. 61
23464580 2013
12
Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation? 61
23730325 2013
13
Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells. 61
23054433 2013
14
Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2. 61
23286582 2013
15
Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. 61
23135727 2013
16
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1. 61
22993189 2012
17
Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo. 61
22623800 2012
18
HTLV-2B strains, similar to those found in several Amerindian tribes, are endemic in central African Bakola Pygmies. 61
21459818 2011
19
Long terminal repeat sequence analysis of HTLV-2 molecular variants identified in Southern Brazil. 61
20939687 2010
20
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo. 61
19553333 2009
21
High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection. 61
19657093 2009
22
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription. 61
19602711 2009
23
Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication. 61
19279097 2009
24
Neurological aspects of HIV/human T lymphotropic virus coinfection. 61
19529747 2009
25
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo. 61
18474092 2008
26
Human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in an HIV-positive patient coinfected with human T lymphotropic virus type 2 following initiation of antiretroviral therapy. 61
17918071 2007
27
Difficulties in the diagnosis of HTLV-2 infection in HIV/AIDS patients from Brazil: comparative performances of serologic and molecular assays, and detection of HTLV-2b subtype. 61
17823751 2007
28
Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line. 61
17140451 2006
29
Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y. 61
16908858 2006
30
Functional analysis of human T lymphotropic virus type 2 Tax proteins. 61
16551350 2006
31
Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus. 61
16140768 2005
32
Prevalence and molecular characterization of human T cell leukemia virus type 2 in a group of intravenous drug users coinfected with HIV type 1 in Portugal. 61
15943566 2005
33
Isolation and confirmation of human T-cell leukemia virus type 2 from peripheral blood mononuclear cells. 61
16061970 2005
34
Growth and manipulation of a human T-cell leukemia virus type 2 full-length molecular clone. 61
16061993 2005
35
Utilization of the CBP but not the p300 co-activator by human T-lymphotropic virus type-2 Tax for p53 inhibition. 61
15156194 2004
36
The MHC class II transcriptional activator (CIITA) inhibits HTLV-2 viral replication by blocking the function of the viral transactivator Tax-2. 61
14525769 2004
37
Functional domain structure of human T-cell leukemia virus type 2 rex. 61
14610204 2003
38
Complete nucleotide sequences of the genomes of two Brazilian specimens of human T lymphotropic virus type 2 (HTLV-2). 61
13678471 2003
39
Divergent simian T-cell lymphotropic virus type 3 (STLV-3) in wild-caught Papio hamadryas papio from Senegal: widespread distribution of STLV-3 in Africa. 61
12477886 2003
40
Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. 61
12370379 2002
41
A comparative study of the human T-cell leukemia virus type 2 integrase expressed in and purified from Escherichia coli and Pichia pastoris. 61
12135562 2002
42
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. 61
11861831 2002
43
Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. 61
11756175 2002
44
Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function. 61
11507189 2001
45
Molecular characterization and phylogenetic analysis of a human T cell leukemia virus type 2 strain from French Guiana. 61
11350670 2001
46
Resistance to Fas-mediated apoptosis of human T-cell lines expressing human T-lymphotropic virus type-2 (HTLV-2) Tax protein. 61
11222094 2001
47
In vitro cellular tropism of human T cell leukemia virus type 2. 61
11080807 2000
48
Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. 61
10684280 2000
49
Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs. 61
10482560 1999
50
Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy. 61
9696872 1998

Variations for Human T-Cell Leukemia Virus Type 2

Expression for Human T-Cell Leukemia Virus Type 2

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 2.

Pathways for Human T-Cell Leukemia Virus Type 2

Pathways related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 STAT5A STAT1 PTBP1 NFKB1 HNRNPA1 HGS
2
Show member pathways
13.98 STAT5A STAT1 NFKB1 IFNG EP300 CSF2
3
Show member pathways
13.78 STAT5A STAT1 NFKB1 EP300 CSF2 CREBBP
4
Show member pathways
13.67 STAT5A STAT1 NFKB1 HGS EP300 CREBBP
5
Show member pathways
13.64 STAT5A NFKB1 IFNG EP300 CSF2 CREBBP
6
Show member pathways
13.49 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
7
Show member pathways
13.46 NFKB1 EP300 CSF2 CREBBP CREB1 CNTN2
8
Show member pathways
13.33 STAT5A STAT1 NFKB1 IFNG CSF2 ADAR
9
Show member pathways
13.1 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
10
Show member pathways
12.96 STAT1 NFKB1 EP300 CREBBP CREB1
11
Show member pathways
12.95 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
12
Show member pathways
12.87 STAT1 NFKB1 EP300 CSF2 CREBBP CREB1
13
Show member pathways
12.86 STAT5A STAT1 NFKB1 EP300 CREBBP
14
Show member pathways
12.79 STAT5A STAT1 NFKB1 EP300 CREBBP
15
Show member pathways
12.76 STAT5A NFKB1 IFNG CREBBP CREB1
16
Show member pathways
12.75 STAT5A STAT1 NFKB1 CREB1
17 12.74 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
18
Show member pathways
12.68 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
19
Show member pathways
12.66 STAT5A STAT1 NFKB1 IFNG EP300 CREBBP
20
Show member pathways
12.65 NFKB1 EP300 CREBBP CREB1
21
Show member pathways
12.64 STAT1 NFKB1 IFNG CREB1
22
Show member pathways
12.6 STAT1 NFKB1 IFNG CREBBP CREB1
23
Show member pathways
12.58 STAT5A STAT1 NFKB1 IFNG
24
Show member pathways
12.58 STAT5A STAT1 NFKB1 IFNG
25 12.55 STAT5A STAT1 NFKB1 IFNG
26
Show member pathways
12.54 NFKB1 EP300 CREBBP ADAR
27
Show member pathways
12.54 STAT1 NFKB1 IFNG CSF2 CREB1
28
Show member pathways
12.53 NFKB1 IFNG EP300 CREBBP
29
Show member pathways
12.36 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
30 12.31 NFKB1 EP300 CREBBP CREB1
31
Show member pathways
12.31 STAT5A STAT1 NFKB1 EP300 CREB1
32
Show member pathways
12.24 STAT1 NFKB1 IFNG EP300 CREB1
33
Show member pathways
12.24 STAT5A STAT1 IFNG EP300 CSF2 CREBBP
34 12.2 STAT5A NFKB1 EP300 CREBBP CREB1
35
Show member pathways
12.19 STAT1 NFKB1 EP300 CREBBP
36
Show member pathways
12.18 STAT5A STAT1 IFNG
37
Show member pathways
12.18 NFKB1 EP300 CREBBP
38 12.17 STAT5A STAT1 HGS CREB1
39 12.16 STAT1 NFKB1 IFNG
40
Show member pathways
12.16 STAT1 NFKB1 IFNG
41 12.16 NFKB1 EP300 CREBBP CREB1
42
Show member pathways
12.15 STAT5A STAT1 NFKB1 CREB1
43
Show member pathways
12.15 STAT5A STAT1 EP300 CREBBP
44 12.14 STAT5A NFKB1 EP300 CSF2 CREBBP CREB1
45
Show member pathways
12.12 NFKB1 CREBBP CREB1
46 12.12 STAT1 NFKB1 EP300 CREB1
47 12.07 STAT5A STAT1 NFKB1 CREB1
48
Show member pathways
12.06 STAT5A STAT1 IFNG
49 12.05 HGS EP300 CREBBP
50 12.05 STAT5A STAT1 CREB1

GO Terms for Human T-Cell Leukemia Virus Type 2

Cellular components related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 STAT5A STAT1 PTBP1 NFKB1 HNRNPA1 EP300

Biological processes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.03 STAT5A STAT1 NFKB1 EP300 CREBBP CREB1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 STAT1 NFKB1 IFNG EP300 CREBBP
3 positive regulation of transcription, DNA-templated GO:0045893 9.88 STAT1 NFKB1 EP300 CREBBP CREB1
4 viral process GO:0016032 9.8 STAT1 HNRNPA1 EP300 CREBBP CREB1
5 rhythmic process GO:0048511 9.76 EP300 CREBBP CREB1
6 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.69 NFKB1 EP300 CREBBP
7 positive regulation of osteoclast differentiation GO:0045672 9.6 IFNG CREB1
8 macrophage differentiation GO:0030225 9.59 IFNG CSF2
9 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.57 NFKB1 CSF2
10 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.55 STAT1 IFNG
11 protein acetylation GO:0006473 9.54 EP300 CREBBP
12 positive regulation of exosomal secretion GO:1903543 9.52 IFNG HGS
13 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 STAT1 IFNG
14 regulation of myeloid cell differentiation GO:0045637 9.46 CSF2 CREBBP
15 interleukin-9-mediated signaling pathway GO:0038113 9.43 STAT5A STAT1
16 positive regulation of type I interferon production GO:0032481 9.43 NFKB1 EP300 CREBBP
17 macrophage derived foam cell differentiation GO:0010742 9.37 STAT1 EP300
18 positive regulation of interleukin-23 production GO:0032747 9.32 IFNG CSF2
19 N-terminal peptidyl-lysine acetylation GO:0018076 9.16 EP300 CREBBP
20 JAK-STAT cascade GO:0007259 9.13 STAT5A STAT1 IFNG
21 positive regulation of transcription of Notch receptor target GO:0007221 8.8 STAT1 EP300 CREBBP

Molecular functions related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.46 NFKB1 EP300 CREBBP CREB1
2 nuclear hormone receptor binding GO:0035257 9.4 STAT1 EP300
3 ubiquitin-like protein ligase binding GO:0044389 9.37 STAT1 HGS
4 acetyltransferase activity GO:0016407 9.32 EP300 CREBBP
5 pre-mRNA binding GO:0036002 9.26 PTBP1 HNRNPA1
6 peptide-lysine-N-acetyltransferase activity GO:0061733 8.96 EP300 CREBBP
7 RNA polymerase II activating transcription factor binding GO:0001102 8.8 EP300 CREBBP CREB1

Sources for Human T-Cell Leukemia Virus Type 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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