MCID: HMN022
MIFTS: 42

Human T-Cell Leukemia Virus Type 2

Categories: Rare diseases, Immune diseases, Cancer diseases, Skin diseases, Blood diseases

Aliases & Classifications for Human T-Cell Leukemia Virus Type 2

MalaCards integrated aliases for Human T-Cell Leukemia Virus Type 2:

Name: Human T-Cell Leukemia Virus Type 2 53
Human T Lymphotropic Virus Type 2 53
Htlv-2 53

Classifications:



Summaries for Human T-Cell Leukemia Virus Type 2

NIH Rare Diseases : 53 Human T-cell leukemia virus, type 2 (HTLV-2) is a retroviral infection that affect the T cells (a type of white blood cell). Although this virus generally causes no signs or symptoms, scientists suspect that some affected people may later develop neurological problems and/or chronic lung infections. HTLV-2 is spread by blood transfusions, sexual contact and sharing needles. It can also be spread from mother to child during birth or breast-feeding. There is no cure or treatment for HTLV-2 and it is considered a lifelong condition; however, most infected people remain asymptomatic (show no symptoms) throughout life.

MalaCards based summary : Human T-Cell Leukemia Virus Type 2, also known as human t lymphotropic virus type 2, is related to tropical spastic paraparesis and t-cell leukemia. An important gene associated with Human T-Cell Leukemia Virus Type 2 is PTBP1 (Polypyrimidine Tract Binding Protein 1), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and lung, and related phenotypes are Decreased TP53 mRNA expression and cellular

Related Diseases for Human T-Cell Leukemia Virus Type 2

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Human T-Cell Leukemia Virus Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 29.7 CNTN2 IFNG NFKB1
2 t-cell leukemia 28.8 CNTN2 CREB1 CREBBP EP300
3 leukemia 10.7
4 campylobacteriosis 10.5 IFNG STAT1
5 trichosporonosis 10.3 CSF2 IFNG
6 candida glabrata 10.3 CSF2 IFNG
7 histoplasmosis 10.3 IFNG STAT1
8 carotid artery thrombosis 10.3 CSF2 IFNG
9 cyclic neutropenia 10.2 CSF2 IFNG
10 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 IFNG STAT1
11 meconium aspiration syndrome 10.2 CSF2 IFNG
12 measles 10.2 ADAR IFNG STAT1
13 cytomegalovirus retinitis 10.2 CSF2 IFNG
14 myelopathy, htlv-1-associated 9.9
15 spastic paraparesis 9.9
16 spasticity 9.9
17 cryptococcal meningitis 9.9 CSF2 IFNG
18 rubinstein-taybi syndrome 1 9.8 CREBBP EP300
19 human immunodeficiency virus type 1 9.8 ADAR IFNG NFKB1 STAT1
20 neonatal leukemia 9.7 CREBBP EP300
21 chromosome 16p13.3 deletion syndrome, proximal 9.3 CREB1 CREBBP EP300
22 hypoxia 9.1 CREB1 CREBBP EP300
23 leukemia, chronic myeloid 9.1 CSF2 STAT1 STAT5A
24 hematologic cancer 8.7 CREBBP CSF2 EP300 STAT5A
25 human t-cell leukemia virus type 1 8.2 CNTN2 CREB1 CREBBP EP300 NFKB1

Graphical network of the top 20 diseases related to Human T-Cell Leukemia Virus Type 2:



Diseases related to Human T-Cell Leukemia Virus Type 2

Symptoms & Phenotypes for Human T-Cell Leukemia Virus Type 2

GenomeRNAi Phenotypes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.62 CREB1 NFKB1

MGI Mouse Phenotypes related to Human T-Cell Leukemia Virus Type 2:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 EP300 NFKB1 IFNG PTBP1 STAT1 STAT5A
2 growth/size/body region MP:0005378 10.22 EP300 NFKB1 IFNG STAT5A PTBP1 STAT1
3 behavior/neurological MP:0005386 10.19 NFKB1 CSF2 IFNG STAT5A STAT1 CREB1
4 homeostasis/metabolism MP:0005376 10.15 NFKB1 CSF2 IFNG EP300 STAT5A STAT1
5 endocrine/exocrine gland MP:0005379 10.14 IFNG EP300 NFKB1 STAT5A STAT1 CREBBP
6 cardiovascular system MP:0005385 10.12 CSF2 IFNG EP300 STAT1 CREB1 ADAR
7 hematopoietic system MP:0005397 10.11 CSF2 IFNG EP300 NFKB1 STAT5A STAT1
8 mortality/aging MP:0010768 10.1 IFNG EP300 NFKB1 STAT5A PTBP1 STAT1
9 embryo MP:0005380 10.09 IFNG EP300 PTBP1 CSF2 CREBBP ADAR
10 immune system MP:0005387 10.08 NFKB1 CSF2 IFNG EP300 STAT5A STAT1
11 craniofacial MP:0005382 10.03 IFNG EP300 NFKB1 PTBP1 CSF2 CREBBP
12 integument MP:0010771 10 IFNG NFKB1 STAT5A STAT1 CSF2 CREBBP
13 nervous system MP:0003631 9.96 EP300 NFKB1 IFNG PTBP1 STAT1 CREBBP
14 liver/biliary system MP:0005370 9.91 IFNG NFKB1 STAT5A STAT1 ADAR CREBBP
15 muscle MP:0005369 9.85 NFKB1 IFNG EP300 STAT1 CREB1 CREBBP
16 neoplasm MP:0002006 9.72 CSF2 IFNG EP300 STAT1 CREBBP
17 normal MP:0002873 9.7 IFNG EP300 NFKB1 STAT5A STAT1 CREBBP
18 respiratory system MP:0005388 9.43 IFNG EP300 NFKB1 CSF2 CREBBP CREB1
19 skeleton MP:0005390 9.23 IFNG NFKB1 PTBP1 STAT1 CREBBP ADAR

Drugs & Therapeutics for Human T-Cell Leukemia Virus Type 2

Drugs for Human T-Cell Leukemia Virus Type 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
2 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
3 Retrovirus Epidemiology Donor Study I (REDS I) Completed NCT00005278
4 Dual Algorithm Post Market Clinical Study Completed NCT03146013
5 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
6 Evaluation of InnoLIA HTLV I/II Score Enrolling by invitation NCT01149837

Search NIH Clinical Center for Human T-Cell Leukemia Virus Type 2

Genetic Tests for Human T-Cell Leukemia Virus Type 2

Anatomical Context for Human T-Cell Leukemia Virus Type 2

MalaCards organs/tissues related to Human T-Cell Leukemia Virus Type 2:

41
T Cells, Breast, Lung

Publications for Human T-Cell Leukemia Virus Type 2

Articles related to Human T-Cell Leukemia Virus Type 2:

(show all 32)
# Title Authors Year
1
Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells. ( 23054433 )
2013
2
Human T cell leukemia virus type 2 tax-mediated NF-I_B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. ( 23135727 )
2013
3
Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-I_B activation? ( 23730325 )
2013
4
Human T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo. ( 22623800 )
2012
5
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1. ( 22993189 )
2012
6
Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication. ( 19279097 )
2009
7
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription. ( 19602711 )
2009
8
Site-specific phosphorylation regulates human T-cell leukemia virus type 2 Rex function in vivo. ( 19553333 )
2009
9
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo. ( 18474092 )
2008
10
Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line. ( 17140451 )
2006
11
Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y. ( 16908858 )
2006
12
Growth and manipulation of a human T-cell leukemia virus type 2 full-length molecular clone. ( 16061993 )
2005
13
Isolation and confirmation of human T-cell leukemia virus type 2 from peripheral blood mononuclear cells. ( 16061970 )
2005
14
Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus. ( 16140768 )
2005
15
Prevalence and molecular characterization of human T cell leukemia virus type 2 in a group of intravenous drug users coinfected with HIV type 1 in Portugal. ( 15943566 )
2005
16
Functional domain structure of human T-cell leukemia virus type 2 rex. ( 14610204 )
2003
17
Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. ( 11756175 )
2002
18
A comparative study of the human T-cell leukemia virus type 2 integrase expressed in and purified from Escherichia coli and Pichia pastoris. ( 12135562 )
2002
19
Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. ( 12370379 )
2002
20
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. ( 11861831 )
2002
21
Molecular characterization and phylogenetic analysis of a human T cell leukemia virus type 2 strain from French Guiana. ( 11350670 )
2001
22
Phosphorylation of two serine residues regulates human T-cell leukemia virus type 2 Rex function. ( 11507189 )
2001
23
In vitro cellular tropism of human T cell leukemia virus type 2. ( 11080807 )
2000
24
Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. ( 10684280 )
2000
25
Human T-cell leukemia virus type 2 Rex protein increases stability and promotes nuclear to cytoplasmic transport of gag/pol and env RNAs. ( 10482560 )
1999
26
Identification of a domain within the human T-cell leukemia virus type 2 envelope required for syncytium induction and replication. ( 9499049 )
1998
27
Mutational analysis of human T-cell leukemia virus type 2 Tax. ( 9343258 )
1997
28
Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs. ( 9060636 )
1997
29
The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes. ( 8764028 )
1996
30
Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation. ( 8764063 )
1996
31
Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements. ( 7474099 )
1995
32
Translation of gag, pro, and pol gene products of human T-cell leukemia virus type 2. ( 2467996 )
1989

Variations for Human T-Cell Leukemia Virus Type 2

Expression for Human T-Cell Leukemia Virus Type 2

Search GEO for disease gene expression data for Human T-Cell Leukemia Virus Type 2.

Pathways for Human T-Cell Leukemia Virus Type 2

Pathways related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.11 CREB1 CREBBP CSF2 EP300 HNRNPA1 NFKB1
2
Show member pathways
13.96 ADAR CREB1 CREBBP CSF2 EP300 IFNG
3
Show member pathways
13.63 CREB1 CREBBP CSF2 EP300 IFNG NFKB1
4
Show member pathways
13.44 CNTN2 CREB1 CREBBP CSF2 EP300 NFKB1
5
Show member pathways
13.43 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
6
Show member pathways
13.32 ADAR CSF2 IFNG NFKB1 STAT1 STAT5A
7
Show member pathways
12.95 CREB1 CREBBP EP300 NFKB1 STAT1
8
Show member pathways
12.87 CREB1 EP300 NFKB1 STAT1 STAT5A
9
Show member pathways
12.85 CREBBP EP300 NFKB1 STAT1 STAT5A
10
Show member pathways
12.77 CREB1 CREBBP CSF2 EP300 NFKB1 STAT1
11
Show member pathways
12.76 CREB1 CREBBP IFNG NFKB1 STAT5A
12
Show member pathways
12.74 CREBBP EP300 NFKB1 STAT1 STAT5A
13 12.73 CREBBP EP300 IFNG NFKB1 STAT1 STAT5A
14
Show member pathways
12.72 ADAR CREBBP EP300 IFNG NFKB1
15
Show member pathways
12.64 ADAR CREBBP EP300 IFNG NFKB1 STAT1
16
Show member pathways
12.59 CREB1 CREBBP IFNG NFKB1 STAT1
17
Show member pathways
12.57 IFNG NFKB1 STAT1 STAT5A
18 12.55 IFNG NFKB1 STAT1 STAT5A
19
Show member pathways
12.48 CREB1 CREBBP EP300 NFKB1
20
Show member pathways
12.43 IFNG NFKB1 STAT1 STAT5A
21
Show member pathways
12.43 CREB1 NFKB1 STAT1 STAT5A
22
Show member pathways
12.41 CREB1 CSF2 IFNG NFKB1
23
Show member pathways
12.4 CREBBP EP300 NFKB1 STAT1 STAT5A
24
Show member pathways
12.39 CREB1 CREBBP EP300 NFKB1 STAT1 STAT5A
25 12.32 CREB1 CREBBP CSF2 EP300 NFKB1 STAT5A
26
Show member pathways
12.32 CREB1 CREBBP CSF2 EP300 NFKB1 STAT1
27
Show member pathways
12.3 ADAR CREBBP CSF2 EP300 IFNG STAT1
28
Show member pathways
12.27 CREB1 CREBBP EP300 NFKB1
29 12.27 CREBBP EP300 IFNG NFKB1
30 12.24 ADAR HNRNPA1 PTBP1
31
Show member pathways
12.23 IFNG STAT1 STAT5A
32
Show member pathways
12.23 EP300 IFNG NFKB1 STAT1
33
Show member pathways
12.23 CREB1 IFNG NFKB1 STAT1 STAT5A
34
Show member pathways
12.22 IFNG NFKB1 STAT1
35 12.21 CREB1 CREBBP EP300 NFKB1 STAT5A
36
Show member pathways
12.2 CREB1 CREBBP EP300
37
Show member pathways
12.18 IFNG STAT1 STAT5A
38
Show member pathways
12.18 CREB1 NFKB1 STAT1
39
Show member pathways
12.18 CREBBP EP300 NFKB1 STAT1
40
Show member pathways
12.17 CREBBP EP300 NFKB1
41
Show member pathways
12.16 CREB1 CREBBP EP300
42
Show member pathways
12.16 IFNG NFKB1 STAT1
43 12.16 IFNG NFKB1 STAT1
44 12.15 CREB1 STAT1 STAT5A
45 12.14 CREB1 CREBBP EP300 NFKB1
46
Show member pathways
12.12 CREBBP EP300 STAT1 STAT5A
47
Show member pathways
12.11 CREB1 CREBBP NFKB1
48 12.1 CREB1 CREBBP EP300 IFNG NFKB1 STAT1
49 12.09 CREB1 EP300 NFKB1 STAT1
50
Show member pathways
12.06 CREBBP EP300 IFNG STAT1

GO Terms for Human T-Cell Leukemia Virus Type 2

Cellular components related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 ADAR CREB1 CREBBP EP300 HNRNPA1 NFKB1
2 histone acetyltransferase complex GO:0000123 8.96 CREBBP EP300

Biological processes related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.98 CREB1 CREBBP EP300 NFKB1 STAT1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.88 CREBBP EP300 IFNG NFKB1 STAT1
3 positive regulation of transcription, DNA-templated GO:0045893 9.8 CREB1 CREBBP EP300 NFKB1 STAT1
4 defense response to virus GO:0051607 9.75 ADAR IFNG STAT1
5 response to hypoxia GO:0001666 9.73 CREB1 CREBBP EP300
6 rhythmic process GO:0048511 9.7 CREB1 CREBBP EP300
7 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.69 CREBBP EP300 NFKB1
8 JAK-STAT cascade GO:0007259 9.57 STAT1 STAT5A
9 positive regulation of osteoclast differentiation GO:0045672 9.55 CREB1 IFNG
10 viral process GO:0016032 9.55 CREB1 CREBBP EP300 HNRNPA1 STAT1
11 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.54 CSF2 NFKB1
12 protein acetylation GO:0006473 9.49 CREBBP EP300
13 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.46 IFNG STAT1
14 regulation of myeloid cell differentiation GO:0045637 9.43 CREBBP CSF2
15 positive regulation of type I interferon production GO:0032481 9.43 CREBBP EP300 NFKB1
16 macrophage derived foam cell differentiation GO:0010742 9.37 EP300 STAT1
17 positive regulation of interleukin-23 production GO:0032747 9.32 CSF2 IFNG
18 N-terminal peptidyl-lysine acetylation GO:0018076 8.96 CREBBP EP300
19 positive regulation of transcription of Notch receptor target GO:0007221 8.8 CREBBP EP300 STAT1

Molecular functions related to Human T-Cell Leukemia Virus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.56 CREB1 CREBBP EP300 NFKB1
2 histone acetyltransferase binding GO:0035035 9.46 CREB1 STAT1
3 nuclear hormone receptor binding GO:0035257 9.43 EP300 STAT1
4 acetyltransferase activity GO:0016407 9.4 CREBBP EP300
5 pre-mRNA binding GO:0036002 9.37 HNRNPA1 PTBP1
6 transcription coregulator activity GO:0003712 9.33 CREB1 CREBBP EP300
7 RNA polymerase II activating transcription factor binding GO:0001102 9.13 CREB1 CREBBP EP300
8 peptide N-acetyltransferase activity GO:0034212 8.62 CREBBP EP300
9 protein binding GO:0005515 10.1 ADAR CNTN2 CREB1 CREBBP CSF2 EP300

Sources for Human T-Cell Leukemia Virus Type 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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