HDL1
MCID: HNT010
MIFTS: 50

Huntington Disease-Like 1 (HDL1)

Categories: Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Huntington Disease-Like 1

MalaCards integrated aliases for Huntington Disease-Like 1:

Name: Huntington Disease-Like 1 58 12 60 76 30 13 6 74
Hdl1 58 12 60 76
Early-Onset Prion Disease with Prominent Psychiatric Features 12 60
Huntington-Like Neurodegenerative Disorder 1 58 12
Huntington's Disease-Like 1 12 15
Hln1 58 12
Prion Disease, Early-Onset, with Prominent Psychiatric Features 58
Huntington-Like Neurodegenerative Disorder, Autosomal Dominant 58
Autosomal Dominant Huntington-Like Neurodegenerative Disorder 12
Huntington-Like Neurodegenerative Disorder 1; Hln1 58
Huntington Disease-Like, Type 1 41

Characteristics:

Orphanet epidemiological data:

60
huntington disease-like 1
Inheritance: Autosomal dominant; Age of onset: Adult;

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
mean age at onset 28 years
prominent psychiatric symptoms


HPO:

33
huntington disease-like 1:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 60  
Rare neurological diseases


Summaries for Huntington Disease-Like 1

Disease Ontology : 12 A prion disease characterized by a phenocopy of Huntington disease (unwanted choreatic movements, behavioral and psychiatric disturbances and dementia) that has material basis in the presence of 8 extra octapeptide repeats in the PRNP gene on chromosome 20p13.

MalaCards based summary : Huntington Disease-Like 1, also known as hdl1, is related to huntington disease-like syndrome and genetic prion diseases, and has symptoms including ataxia, restlessness and personality changes. An important gene associated with Huntington Disease-Like 1 is PRNP (Prion Protein), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Selenium Micronutrient Network. Affiliated tissues include eye, brain and heart, and related phenotypes are chorea and depressivity

UniProtKB/Swiss-Prot : 76 Huntington disease-like 1: Autosomal dominant, early-onset neurodegenerative disorder with prominent psychiatric features.

Description from OMIM: 603218

Related Diseases for Huntington Disease-Like 1

Diseases in the Huntington Disease family:

Huntington Disease-Like 1 Huntington Disease-Like 3
Huntington Disease-Like 2 Juvenile Huntington Disease
Huntington Disease-Like Syndrome Huntington Disease-Like Syndrome Due to C9orf72 Expansions

Diseases related to Huntington Disease-Like 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 huntington disease-like syndrome 11.3
2 genetic prion diseases 10.2 APOE PRNP
3 familial lcat deficiency 10.1 APOA1 APOE
4 huntington disease-like 3 10.1
5 huntington disease-like 2 10.1
6 hepatic lipase deficiency 10.1 APOA1 APOE
7 cerebral atherosclerosis 10.1 APOA1 APOE
8 choreatic disease 10.0 JPH3 TBP
9 spinocerebellar ataxia 17 10.0 JPH3 TBP
10 aphasia 10.0 APOE PRNP
11 aortic atherosclerosis 10.0 APOE CETP
12 cerebral amyloid angiopathy, cst3-related 10.0 APOE PRNP
13 spinocerebellar ataxia 12 10.0 PRNP TBP
14 alzheimer disease 2 10.0 APOE CETP
15 dentatorubral-pallidoluysian atrophy 10.0 JPH3 TBP
16 xanthoma disseminatum 9.9 APOB APOE
17 huntington disease 9.9 JPH3 PRNP TBP
18 hyperlipidemia, familial combined 9.9 APOA1 APOB
19 hypercholesterolemia, autosomal dominant, type b 9.9 APOB APOE
20 dysbaric osteonecrosis 9.9 APOA1 APOB
21 defective apolipoprotein b-100 9.9 APOB APOE
22 lipoprotein glomerulopathy 9.9 APOB APOE
23 schnyder corneal dystrophy 9.9 APOB APOE
24 dementia, lewy body 9.9 APOE PRNP
25 fetal macrosomia 9.9 APOA1 APOB
26 sea-blue histiocyte disease 9.9 APOB APOE
27 chylomicron retention disease 9.9 APOA1 APOB
28 homozygous familial hypercholesterolemia 9.9 APOB APOE
29 vitamin e, familial isolated deficiency of 9.9 APOA1 APOB
30 xanthomatosis 9.8 APOB APOE
31 inherited metabolic disorder 9.7 APOA1 APOB
32 peripheral vascular disease 9.7 APOA1 APOB
33 hyperlipoproteinemia, type v 9.7 APOA1 APOB APOE
34 leukodystrophy, hypomyelinating, 3 9.7 APOA1 APOB APOE
35 ischemic heart disease 9.7 APOA1 APOB APOE
36 hypolipoproteinemia 9.7 APOA1 APOB APOE
37 hypoalphalipoproteinemia, primary 9.7 APOA1 APOB CETP
38 hypobetalipoproteinemia, familial, 2 9.7 APOA1 APOB CETP
39 carotid artery disease 9.7 APOA1 APOB APOE
40 coronary artery anomaly 9.6 APOA1 APOB CETP
41 arteriosclerosis 9.6 APOA1 APOB APOE
42 cerebrovascular disease 9.6 APOA1 APOB APOE
43 macular degeneration, age-related, 1 9.6 APOB APOE CETP
44 acquired metabolic disease 9.5 APOA1 APOB
45 hypertriglyceridemia, familial 9.4 APOA1 APOB APOE CETP
46 hyperlipoproteinemia, type iii 9.4 APOA1 APOB APOE CETP
47 arcus corneae 9.4 APOA1 APOB APOE CETP
48 hyperalphalipoproteinemia 1 9.4 APOA1 APOB APOE CETP
49 coronary stenosis 9.4 APOA1 APOB APOE CETP
50 lecithin:cholesterol acyltransferase deficiency 9.4 APOA1 APOB APOE CETP

Graphical network of the top 20 diseases related to Huntington Disease-Like 1:



Diseases related to Huntington Disease-Like 1

Symptoms & Phenotypes for Huntington Disease-Like 1

Human phenotypes related to Huntington Disease-Like 1:

60 33 (show top 50) (show all 51)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chorea 60 33 hallmark (90%) Very frequent (99-80%) HP:0002072
2 depressivity 60 33 frequent (33%) Frequent (79-30%) HP:0000716
3 dysarthria 60 33 frequent (33%) Frequent (79-30%) HP:0001260
4 gait ataxia 60 33 frequent (33%) Frequent (79-30%) HP:0002066
5 ventriculomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002119
6 dementia 60 33 frequent (33%) Frequent (79-30%) HP:0000726
7 delusions 60 33 frequent (33%) Frequent (79-30%) HP:0000746
8 nystagmus 60 33 occasional (7.5%) Occasional (29-5%) HP:0000639
9 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
10 eeg abnormality 60 33 occasional (7.5%) Occasional (29-5%) HP:0002353
11 delayed speech and language development 60 33 occasional (7.5%) Occasional (29-5%) HP:0000750
12 weight loss 60 33 occasional (7.5%) Occasional (29-5%) HP:0001824
13 slurred speech 60 33 occasional (7.5%) Occasional (29-5%) HP:0001350
14 dysmetria 60 33 occasional (7.5%) Occasional (29-5%) HP:0001310
15 poor fine motor coordination 60 33 occasional (7.5%) Occasional (29-5%) HP:0007010
16 mask-like facies 60 33 occasional (7.5%) Occasional (29-5%) HP:0000298
17 cerebral cortical atrophy 60 33 occasional (7.5%) Occasional (29-5%) HP:0002120
18 memory impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0002354
19 clumsiness 60 33 occasional (7.5%) Occasional (29-5%) HP:0002312
20 cerebellar atrophy 60 33 occasional (7.5%) Occasional (29-5%) HP:0001272
21 bradykinesia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002067
22 abnormality of the shoulder 60 33 occasional (7.5%) Occasional (29-5%) HP:0003043
23 hypokinesia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002375
24 generalized hypotonia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001290
25 frequent falls 60 33 occasional (7.5%) Occasional (29-5%) HP:0002359
26 restlessness 60 33 occasional (7.5%) Occasional (29-5%) HP:0000711
27 gliosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002171
28 hyperactive deep tendon reflexes 60 33 occasional (7.5%) Occasional (29-5%) HP:0006801
29 slow saccadic eye movements 60 33 occasional (7.5%) Occasional (29-5%) HP:0000514
30 jerky ocular pursuit movements 60 33 occasional (7.5%) Occasional (29-5%) HP:0008003
31 abnormality of the basal ganglia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002134
32 abnormal posturing 60 33 occasional (7.5%) Occasional (29-5%) HP:0002533
33 jerky head movements 60 33 occasional (7.5%) Occasional (29-5%) HP:0006961
34 simultanapraxia 60 33 occasional (7.5%) Occasional (29-5%) HP:0040201
35 incoordination 60 33 Occasional (29-5%) HP:0002311
36 abnormality of eye movement 60 Occasional (29-5%)
37 gait disturbance 60 Frequent (79-30%)
38 behavioral abnormality 60 Frequent (79-30%)
39 cognitive impairment 60 Frequent (79-30%)
40 anxiety 33 HP:0000739
41 abnormality of saccadic eye movements 60 Occasional (29-5%)
42 rigidity 33 HP:0002063
43 aggressive behavior 33 HP:0000718
44 involuntary movements 60 Frequent (79-30%)
45 abnormality of higher mental function 60 Occasional (29-5%)
46 personality changes 33 HP:0000751
47 unsteady gait 33 HP:0002317
48 abnormality of ocular smooth pursuit 60 Occasional (29-5%)
49 abnormal head movements 60 Occasional (29-5%)
50 global brain atrophy 33 HP:0002283

Symptoms via clinical synopsis from OMIM:

58
Neurologic Central Nervous System:
ataxia
dysarthria
chorea
dysmetria
rigidity
more
Neurologic Behavioral Psychiatric Manifestations:
anxiety
restlessness
personality changes
delusions
depression
more

Clinical features from OMIM:

603218

UMLS symptoms related to Huntington Disease-Like 1:


ataxia, restlessness, personality changes, muscle rigidity, grimacing

GenomeRNAi Phenotypes related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE CETP
2 Increased LDL uptake GR00340-A-1 8.62 APOA1 APOE

Drugs & Therapeutics for Huntington Disease-Like 1

Search Clinical Trials , NIH Clinical Center for Huntington Disease-Like 1

Genetic Tests for Huntington Disease-Like 1

Genetic tests related to Huntington Disease-Like 1:

# Genetic test Affiliating Genes
1 Huntington Disease-Like 1 30 PRNP

Anatomical Context for Huntington Disease-Like 1

MalaCards organs/tissues related to Huntington Disease-Like 1:

42
Eye, Brain, Heart, Cortex, Liver

Publications for Huntington Disease-Like 1

Articles related to Huntington Disease-Like 1:

(show all 29)
# Title Authors Year
1
Creutzfeldt-Jakob disease with a novel insertion and codon 219 Lys/Lys polymorphism in PRNP. ( 15557533 )
2004
2
Creutzfeldt-Jakob disease with a novel extra-repeat insertional mutation in the PRNP gene. ( 14610142 )
2003
3
Novel prion protein insert mutation associated with prolonged neurodegenerative illness. ( 12771252 )
2003
4
Huntington disease phenocopy is a familial prion disease. ( 11593450 )
2001
5
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation. ( 10805813 )
2000
6
Catabolism of HDL1 cholesteryl ester in the rat. Effect of ethinyl estradiol treatment. ( 10488433 )
1999
7
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. ( 9883727 )
1998
8
A prion disease with a novel 96-base pair insertional mutation in the prion protein gene. ( 8618679 )
1996
9
Prion disease associated with a novel nine octapeptide repeat insertion in the PRNP gene. ( 8750875 )
1995
10
Influence of age on hepatic uptake of HDL1-cholesterol in male Wistar rats with bile duct cannulation. ( 7961593 )
1994
11
Role of HDL1 in cholesteryl ester uptake in rats. ( 8496663 )
1993
12
Atypical Creutzfeldt-Jakob disease in an American family with an insert mutation in the PRNP amyloid precursor gene. ( 1736177 )
1992
13
Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies. ( 1352724 )
1992
14
Uncommon phenotype for a codon 178 mutation of the human PrP gene. ( 1353344 )
1992
15
Effect of HDL1 infusion on biliary secretion in perfused rat liver. ( 1290806 )
1992
16
Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. ( 1675319 )
1991
17
Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene. ( 1683708 )
1991
18
An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease. ( 2159587 )
1990
19
Plasma apolipoprotein E, high density lipoprotein1 (HDL1) and urinary mevalonate excretion in pancreatectomized diabetic dogs: effects of insulin and lovastatin. ( 2248616 )
1990
20
Prion dementia without characteristic pathology. ( 1973256 )
1990
21
Insertion in prion protein gene in familial Creutzfeldt-Jakob disease. ( 2563037 )
1989
22
Proteolytic degradation of HDL1 on the fat cell surface is nutritionally regulated. ( 2590527 )
1989
23
Proliferative effect of high density lipoprotein (HDL) and HDL fractions (HDL1,2, HDL3) on virus transformed lymphoblastoid cells. ( 2788459 )
1989
24
Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis. ( 2567794 )
1989
25
Reduction in plasma apolipoprotein E and HDL1 levels in rats with essential fatty acid deficiency. ( 3121811 )
1987
26
In vivo conversion of human HDL3 to HDL2 and apoE-rich HDL1 in the rat: effects of lipid transfer protein. ( 3572251 )
1987
27
Dietary effects on serum lipoproteins of dyslipoproteinemic baboons with high HDL1. ( 3096264 )
1986
28
Isolation of human serum HDL1 by zonal ultracentrifugation. ( 7130858 )
1982
29
Isolation and partial characterization of high-density lipoprotein HDL1 from rat plasma by gradient centrifugation. ( 230819 )
1979

Variations for Huntington Disease-Like 1

ClinVar genetic disease variations for Huntington Disease-Like 1:

6 (show all 24)
# Gene Variation Type Significance SNP ID Assembly Location
1 PRNP NM_000311.4(PRNP) NT expansion Pathogenic rs193922906 GRCh37 Chromosome 20, 4680026: 4680049
2 PRNP NM_000311.4(PRNP) NT expansion Pathogenic rs193922906 GRCh38 Chromosome 20, 4699380: 4699403
3 PRNP NM_000311.4(PRNP): c.598G> A (p.Glu200Lys) single nucleotide variant Pathogenic rs28933385 GRCh37 Chromosome 20, 4680464: 4680464
4 PRNP NM_000311.4(PRNP): c.598G> A (p.Glu200Lys) single nucleotide variant Pathogenic rs28933385 GRCh38 Chromosome 20, 4699818: 4699818
5 PRNP NM_000311.4(PRNP): c.593T> C (p.Phe198Ser) single nucleotide variant Pathogenic rs74315405 GRCh37 Chromosome 20, 4680459: 4680459
6 PRNP NM_000311.4(PRNP): c.593T> C (p.Phe198Ser) single nucleotide variant Pathogenic rs74315405 GRCh38 Chromosome 20, 4699813: 4699813
7 PRNP NM_000311.4(PRNP): c.628G> A (p.Val210Ile) single nucleotide variant Pathogenic rs74315407 GRCh37 Chromosome 20, 4680494: 4680494
8 PRNP NM_000311.4(PRNP): c.628G> A (p.Val210Ile) single nucleotide variant Pathogenic rs74315407 GRCh38 Chromosome 20, 4699848: 4699848
9 PRNP NM_000311.4(PRNP): c.512A> G (p.Asn171Ser) single nucleotide variant Benign rs16990018 GRCh37 Chromosome 20, 4680378: 4680378
10 PRNP NM_000311.4(PRNP): c.512A> G (p.Asn171Ser) single nucleotide variant Benign rs16990018 GRCh38 Chromosome 20, 4699732: 4699732
11 PRNP NM_000311.3(PRNP): c.204_227del24 (p.Pro84_Gln91del) deletion Likely benign rs193922906 GRCh37 Chromosome 20, 4680070: 4680093
12 PRNP NM_000311.3(PRNP): c.204_227del24 (p.Pro84_Gln91del) deletion Likely benign rs193922906 GRCh38 Chromosome 20, 4699424: 4699447
13 PRNP NM_001271561.2(PRNP): c.139C> T (p.Pro47Ser) single nucleotide variant Benign/Likely benign rs112637437 GRCh38 Chromosome 20, 4699448: 4699448
14 PRNP NM_001271561.2(PRNP): c.139C> T (p.Pro47Ser) single nucleotide variant Benign/Likely benign rs112637437 GRCh37 Chromosome 20, 4680094: 4680094
15 PRNP NM_000311.4(PRNP): c.160G> A (p.Gly54Ser) single nucleotide variant Likely benign rs763524380 GRCh38 Chromosome 20, 4699380: 4699380
16 PRNP NM_000311.4(PRNP): c.160G> A (p.Gly54Ser) single nucleotide variant Likely benign rs763524380 GRCh37 Chromosome 20, 4680026: 4680026
17 PRNP NM_000311.4(PRNP): c.246A> G (p.Gly82=) single nucleotide variant Benign rs62643364 GRCh38 Chromosome 20, 4699466: 4699466
18 PRNP NM_000311.4(PRNP): c.246A> G (p.Gly82=) single nucleotide variant Benign rs62643364 GRCh37 Chromosome 20, 4680112: 4680112
19 PRNP NM_000311.4(PRNP): c.351A> G (p.Ala117=) single nucleotide variant Benign rs8124214 GRCh38 Chromosome 20, 4699571: 4699571
20 PRNP NM_000311.4(PRNP): c.351A> G (p.Ala117=) single nucleotide variant Benign rs8124214 GRCh37 Chromosome 20, 4680217: 4680217
21 PRNP NM_000311.4(PRNP): c.246_269del (p.Pro84_Gln91del) deletion Benign rs138688873 GRCh38 Chromosome 20, 4699466: 4699489
22 PRNP NM_000311.4(PRNP): c.246_269del (p.Pro84_Gln91del) deletion Benign rs138688873 GRCh37 Chromosome 20, 4680112: 4680135
23 PRNP NM_000311.4(PRNP): c.462G> A (p.Met154Ile) single nucleotide variant Uncertain significance GRCh37 Chromosome 20, 4680328: 4680328
24 PRNP NM_000311.4(PRNP): c.462G> A (p.Met154Ile) single nucleotide variant Uncertain significance GRCh38 Chromosome 20, 4699682: 4699682

Expression for Huntington Disease-Like 1

Search GEO for disease gene expression data for Huntington Disease-Like 1.

Pathways for Huntington Disease-Like 1

Pathways related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 APOA1 APOB APOE
2
Show member pathways
11.88 APOA1 APOB APOE
3
Show member pathways
11.83 APOA1 APOB APOE
4
Show member pathways
11.79 APOA1 APOB APOE CETP
5
Show member pathways
11.35 APOA1 APOB APOE
6
Show member pathways
11.05 APOA1 APOB
7
Show member pathways
11 APOA1 APOB APOE CETP
8 10.64 APOA1 APOB

GO Terms for Huntington Disease-Like 1

Cellular components related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.89 APOA1 APOB APOE CETP PRNP
2 endoplasmic reticulum lumen GO:0005788 9.65 APOA1 APOB APOE
3 early endosome GO:0005769 9.63 APOA1 APOB APOE
4 high-density lipoprotein particle GO:0034364 9.54 APOA1 APOE CETP
5 extracellular vesicle GO:1903561 9.51 APOA1 APOE
6 very-low-density lipoprotein particle GO:0034361 9.5 APOA1 APOB APOE
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 APOB APOE
8 endocytic vesicle lumen GO:0071682 9.43 APOA1 APOB APOE
9 discoidal high-density lipoprotein particle GO:0034365 9.4 APOA1 APOE
10 low-density lipoprotein particle GO:0034362 9.33 APOA1 APOB APOE
11 chylomicron GO:0042627 9.13 APOA1 APOB APOE
12 intermediate-density lipoprotein particle GO:0034363 8.8 APOA1 APOB APOE

Biological processes related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.95 APOA1 APOB APOE CETP
2 post-translational protein modification GO:0043687 9.86 APOA1 APOB APOE
3 cellular protein metabolic process GO:0044267 9.84 APOA1 APOB APOE
4 receptor-mediated endocytosis GO:0006898 9.84 APOA1 APOB APOE
5 lipid transport GO:0006869 9.8 APOA1 APOB APOE CETP
6 steroid metabolic process GO:0008202 9.78 APOA1 APOB APOE CETP
7 retinoid metabolic process GO:0001523 9.75 APOA1 APOB APOE
8 triglyceride homeostasis GO:0070328 9.73 APOA1 APOE CETP
9 cholesterol transport GO:0030301 9.72 APOA1 APOB CETP
10 triglyceride catabolic process GO:0019433 9.71 APOA1 APOB APOE
11 cholesterol homeostasis GO:0042632 9.71 APOA1 APOB APOE CETP
12 cholesterol efflux GO:0033344 9.7 APOA1 APOB APOE
13 lipoprotein metabolic process GO:0042157 9.69 APOA1 APOB APOE
14 phospholipid transport GO:0015914 9.68 APOA1 CETP
15 cholesterol biosynthetic process GO:0006695 9.68 APOA1 APOE
16 lipid homeostasis GO:0055088 9.68 APOE CETP
17 triglyceride metabolic process GO:0006641 9.67 APOE CETP
18 long-term memory GO:0007616 9.67 APOE PRNP
19 artery morphogenesis GO:0048844 9.66 APOB APOE
20 regulation of neuronal synaptic plasticity GO:0048168 9.65 APOE JPH3
21 positive regulation of lipid biosynthetic process GO:0046889 9.65 APOA1 APOE
22 high-density lipoprotein particle assembly GO:0034380 9.64 APOA1 APOE
23 phospholipid efflux GO:0033700 9.64 APOA1 APOE
24 high-density lipoprotein particle clearance GO:0034384 9.63 APOA1 APOE
25 negative regulation of amyloid-beta formation GO:1902430 9.63 APOE PRNP
26 reverse cholesterol transport GO:0043691 9.63 APOA1 APOE CETP
27 negative regulation of long-term synaptic potentiation GO:1900272 9.62 APOE PRNP
28 phospholipid homeostasis GO:0055091 9.62 APOA1 CETP
29 cholesterol metabolic process GO:0008203 9.62 APOA1 APOB APOE CETP
30 positive regulation of cholesterol esterification GO:0010873 9.61 APOA1 APOE
31 chylomicron remnant clearance GO:0034382 9.61 APOB APOE
32 high-density lipoprotein particle remodeling GO:0034375 9.61 APOA1 APOE CETP
33 regulation of Cdc42 protein signal transduction GO:0032489 9.6 APOA1 APOE
34 regulation of cholesterol transport GO:0032374 9.59 APOA1 APOE
35 very-low-density lipoprotein particle clearance GO:0034447 9.58 APOB APOE
36 lipoprotein catabolic process GO:0042159 9.57 APOB APOE
37 low-density lipoprotein particle remodeling GO:0034374 9.54 APOB APOE CETP
38 chylomicron assembly GO:0034378 9.43 APOA1 APOB APOE
39 very-low-density lipoprotein particle remodeling GO:0034372 9.33 APOA1 APOE CETP
40 chylomicron remodeling GO:0034371 9.13 APOA1 APOB APOE
41 lipoprotein biosynthetic process GO:0042158 8.8 APOA1 APOB APOE

Molecular functions related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.61 APOA1 APOB APOE
2 lipid binding GO:0008289 9.5 APOA1 APOE CETP
3 low-density lipoprotein particle receptor binding GO:0050750 9.48 APOB APOE
4 phospholipid transporter activity GO:0005548 9.46 APOA1 CETP
5 amyloid-beta binding GO:0001540 9.43 APOA1 APOE PRNP
6 lipoprotein particle binding GO:0071813 9.4 APOA1 APOE
7 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOA1 APOE
8 cholesterol binding GO:0015485 9.33 APOA1 APOE CETP
9 lipid transporter activity GO:0005319 9.26 APOA1 APOB APOE CETP
10 cholesterol transporter activity GO:0017127 8.92 APOA1 APOB APOE CETP

Sources for Huntington Disease-Like 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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