HDL1
MCID: HNT010
MIFTS: 49

Huntington Disease-Like 1 (HDL1)

Categories: Eye diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Huntington Disease-Like 1

MalaCards integrated aliases for Huntington Disease-Like 1:

Name: Huntington Disease-Like 1 57 12 59 74 29 13 6 72
Hdl1 57 12 59 74
Early-Onset Prion Disease with Prominent Psychiatric Features 12 59
Huntington-Like Neurodegenerative Disorder 1 57 12
Huntington's Disease-Like 1 12 15
Hln1 57 12
Prion Disease, Early-Onset, with Prominent Psychiatric Features 57
Huntington-Like Neurodegenerative Disorder, Autosomal Dominant 57
Autosomal Dominant Huntington-Like Neurodegenerative Disorder 12
Huntington-Like Neurodegenerative Disorder 1; Hln1 57
Huntington Disease-Like, Type 1 40

Characteristics:

Orphanet epidemiological data:

59
huntington disease-like 1
Inheritance: Autosomal dominant; Age of onset: Adult;

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
mean age at onset 28 years
prominent psychiatric symptoms


HPO:

32
huntington disease-like 1:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0090103
OMIM 57 603218
ICD10 33 G10
ICD10 via Orphanet 34 G10
UMLS via Orphanet 73 C1864112
Orphanet 59 ORPHA157941
MedGen 42 C1864112
UMLS 72 C1864112

Summaries for Huntington Disease-Like 1

Disease Ontology : 12 A prion disease that is characterized by a phenocopy of Huntington disease (unwanted choreatic movements, behavioral and psychiatric disturbances and dementia) that has material basis in autosomal dominant inheritance of 8 extra octapeptide repeats in the prion protein (PRNP) gene on chromosome 20p13.

MalaCards based summary : Huntington Disease-Like 1, also known as hdl1, is related to abetalipoproteinemia and tangier disease, and has symptoms including ataxia, restlessness and personality changes. An important gene associated with Huntington Disease-Like 1 is PRNP (Prion Protein), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Selenium Micronutrient Network. Affiliated tissues include eye, brain and liver, and related phenotypes are chorea and depressivity

UniProtKB/Swiss-Prot : 74 Huntington disease-like 1: Autosomal dominant, early-onset neurodegenerative disorder with prominent psychiatric features.

More information from OMIM: 603218

Related Diseases for Huntington Disease-Like 1

Diseases in the Huntington Disease family:

Huntington Disease-Like 1 Huntington Disease-Like 3
Huntington Disease-Like 2 Juvenile Huntington Disease
Huntington Disease-Like Syndrome Huntington Disease-Like Syndrome Due to C9orf72 Expansions

Diseases related to Huntington Disease-Like 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 abetalipoproteinemia 28.7 CETP APOE APOB APOA1
2 tangier disease 28.7 CETP APOE APOB APOA1
3 lipid metabolism disorder 28.6 CETP APOE APOB APOA1
4 huntington disease-like syndrome 11.4
5 huntington disease-like 2 10.4
6 hypercholesterolemia, familial, 1 10.3
7 genetic prion diseases 10.3 PRNP APOE
8 familial lcat deficiency 10.2 APOE APOA1
9 cerebral atherosclerosis 10.2 APOE APOA1
10 hepatic lipase deficiency 10.2 APOE APOA1
11 huntington disease-like 3 10.1
12 familial hypercholesterolemia 10.1
13 hyperglycemia 10.1
14 rapidly involuting congenital hemangioma 10.1
15 choreatic disease 10.1 TBP JPH3
16 spinocerebellar ataxia 17 10.0 TBP JPH3
17 aortic atherosclerosis 10.0 CETP APOE
18 aphasia 10.0 PRNP APOE
19 cerebral amyloid angiopathy, cst3-related 10.0 PRNP APOE
20 spinocerebellar ataxia 12 10.0 TBP PRNP
21 alzheimer disease 2 10.0 CETP APOE
22 dentatorubral-pallidoluysian atrophy 9.9 TBP JPH3
23 xanthoma disseminatum 9.9 APOE APOB
24 huntington disease 9.8 TBP PRNP JPH3
25 dysbaric osteonecrosis 9.8 APOB APOA1
26 defective apolipoprotein b-100 9.8 APOE APOB
27 lipoprotein glomerulopathy 9.8 APOE APOB
28 dementia, lewy body 9.8 PRNP APOE
29 fetal macrosomia 9.8 APOB APOA1
30 schnyder corneal dystrophy 9.8 APOE APOB
31 vitamin e, familial isolated deficiency of 9.8 APOB APOA1
32 sea-blue histiocyte disease 9.8 APOE APOB
33 homozygous familial hypercholesterolemia 9.8 APOE APOB
34 chylomicron retention disease 9.8 APOB APOA1
35 xanthomatosis 9.7 APOE APOB
36 inherited metabolic disorder 9.6 APOB APOA1
37 peripheral vascular disease 9.5 APOB APOA1
38 leukodystrophy, hypomyelinating, 3 9.4 APOE APOB APOA1
39 hyperlipoproteinemia, type v 9.4 APOE APOB APOA1
40 hypolipoproteinemia 9.4 APOE APOB APOA1
41 hypobetalipoproteinemia, familial, 2 9.4 CETP APOB APOA1
42 carotid artery disease 9.4 APOE APOB APOA1
43 coronary artery anomaly 9.4 CETP APOB APOA1
44 arteriosclerosis 9.4 APOE APOB APOA1
45 cerebrovascular disease 9.4 APOE APOB APOA1
46 macular degeneration, age-related, 1 9.3 CETP APOE APOB
47 acquired metabolic disease 9.3 APOB APOA1
48 hypertriglyceridemia, familial 9.0 CETP APOE APOB APOA1
49 hyperlipoproteinemia, type iii 9.0 CETP APOE APOB APOA1
50 arcus corneae 9.0 CETP APOE APOB APOA1

Graphical network of the top 20 diseases related to Huntington Disease-Like 1:



Diseases related to Huntington Disease-Like 1

Symptoms & Phenotypes for Huntington Disease-Like 1

Human phenotypes related to Huntington Disease-Like 1:

59 32 (show top 50) (show all 51)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chorea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002072
2 depressivity 59 32 frequent (33%) Frequent (79-30%) HP:0000716
3 dysarthria 59 32 frequent (33%) Frequent (79-30%) HP:0001260
4 gait ataxia 59 32 frequent (33%) Frequent (79-30%) HP:0002066
5 ventriculomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002119
6 dementia 59 32 frequent (33%) Frequent (79-30%) HP:0000726
7 delusions 59 32 frequent (33%) Frequent (79-30%) HP:0000746
8 nystagmus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000639
9 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
10 eeg abnormality 59 32 occasional (7.5%) Occasional (29-5%) HP:0002353
11 delayed speech and language development 59 32 occasional (7.5%) Occasional (29-5%) HP:0000750
12 generalized hypotonia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001290
13 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
14 slurred speech 59 32 occasional (7.5%) Occasional (29-5%) HP:0001350
15 memory impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0002354
16 dysmetria 59 32 occasional (7.5%) Occasional (29-5%) HP:0001310
17 poor fine motor coordination 59 32 occasional (7.5%) Occasional (29-5%) HP:0007010
18 mask-like facies 59 32 occasional (7.5%) Occasional (29-5%) HP:0000298
19 cerebral cortical atrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002120
20 clumsiness 59 32 occasional (7.5%) Occasional (29-5%) HP:0002312
21 cerebellar atrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001272
22 bradykinesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002067
23 abnormality of the shoulder 59 32 occasional (7.5%) Occasional (29-5%) HP:0003043
24 hypokinesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002375
25 frequent falls 59 32 occasional (7.5%) Occasional (29-5%) HP:0002359
26 restlessness 59 32 occasional (7.5%) Occasional (29-5%) HP:0000711
27 gliosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002171
28 hyperactive deep tendon reflexes 59 32 occasional (7.5%) Occasional (29-5%) HP:0006801
29 slow saccadic eye movements 59 32 occasional (7.5%) Occasional (29-5%) HP:0000514
30 jerky ocular pursuit movements 59 32 occasional (7.5%) Occasional (29-5%) HP:0008003
31 abnormality of the basal ganglia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002134
32 abnormal posturing 59 32 occasional (7.5%) Occasional (29-5%) HP:0002533
33 jerky head movements 59 32 occasional (7.5%) Occasional (29-5%) HP:0006961
34 simultanapraxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0040201
35 incoordination 59 32 Occasional (29-5%) HP:0002311
36 abnormality of eye movement 59 Occasional (29-5%)
37 gait disturbance 59 Frequent (79-30%)
38 behavioral abnormality 59 Frequent (79-30%)
39 cognitive impairment 59 Frequent (79-30%)
40 anxiety 32 HP:0000739
41 abnormality of saccadic eye movements 59 Occasional (29-5%)
42 rigidity 32 HP:0002063
43 aggressive behavior 32 HP:0000718
44 involuntary movements 59 Frequent (79-30%)
45 abnormality of higher mental function 59 Occasional (29-5%)
46 personality changes 32 HP:0000751
47 unsteady gait 32 HP:0002317
48 abnormality of ocular smooth pursuit 59 Occasional (29-5%)
49 abnormal head movements 59 Occasional (29-5%)
50 global brain atrophy 32 HP:0002283

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
ataxia
dysarthria
chorea
dysmetria
rigidity
more
Neurologic Behavioral Psychiatric Manifestations:
anxiety
restlessness
personality changes
delusions
depression
more

Clinical features from OMIM:

603218

UMLS symptoms related to Huntington Disease-Like 1:


ataxia, restlessness, personality changes, muscle rigidity, grimacing

GenomeRNAi Phenotypes related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE CETP
2 Increased LDL uptake GR00340-A-1 8.62 APOA1 APOE

Drugs & Therapeutics for Huntington Disease-Like 1

Search Clinical Trials , NIH Clinical Center for Huntington Disease-Like 1

Genetic Tests for Huntington Disease-Like 1

Genetic tests related to Huntington Disease-Like 1:

# Genetic test Affiliating Genes
1 Huntington Disease-Like 1 29 PRNP

Anatomical Context for Huntington Disease-Like 1

MalaCards organs/tissues related to Huntington Disease-Like 1:

41
Eye, Brain, Liver, Cortex, Adipocyte, Testes, Spleen

Publications for Huntington Disease-Like 1

Articles related to Huntington Disease-Like 1:

(show top 50) (show all 196)
# Title Authors PMID Year
1
Huntington disease phenocopy is a familial prion disease. 8 71
11593450 2001
2
Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene. 8 71
1683708 1991
3
Genetic Prion Diseases 38 71
20301407 2003
4
Creutzfeldt-Jakob disease with a novel insertion and codon 219 Lys/Lys polymorphism in PRNP. 71
15557533 2004
5
Creutzfeldt-Jakob disease with a novel extra-repeat insertional mutation in the PRNP gene. 71
14610142 2003
6
Novel prion protein insert mutation associated with prolonged neurodegenerative illness. 71
12771252 2003
7
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation. 71
10805813 2000
8
Prominent psychiatric features and early onset in an inherited prion disease with a new insertional mutation in the prion protein gene. 8
10581230 1999
9
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. 71
9883727 1998
10
A Huntington disease-like neurodegenerative disorder maps to chromosome 20p. 8
9792871 1998
11
A prion disease with a novel 96-base pair insertional mutation in the prion protein gene. 71
8618679 1996
12
Prion disease associated with a novel nine octapeptide repeat insertion in the PRNP gene. 71
8750875 1995
13
Hypokinesia and presenile dementia in a Dutch family with a novel insertion in the prion protein gene. 8
8595485 1995
14
Huntington disease without CAG expansion: phenocopies or errors in assignment? 8
8178825 1994
15
Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies. 71
1352724 1992
16
Uncommon phenotype for a codon 178 mutation of the human PrP gene. 71
1353344 1992
17
Atypical Creutzfeldt-Jakob disease in an American family with an insert mutation in the PRNP amyloid precursor gene. 71
1736177 1992
18
Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease. 71
1675319 1991
19
Prion dementia without characteristic pathology. 71
1973256 1990
20
An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease. 71
2159587 1990
21
Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis. 71
2567794 1989
22
Insertion in prion protein gene in familial Creutzfeldt-Jakob disease. 71
2563037 1989
23
Cholesterol Subfraction Analysis in Patients with Acute Coronary Syndrome. 38
29852873 2019
24
High-Density Lipoprotein and Low-Density Lipoprotein Subfractions in Patients with Chronic Kidney Disease. 38
27697068 2017
25
Lipoprotein Subfractions, Uric Acid and Cardiovascular Risk in End-Stage Renal Disease (ESRD) Patients. 38
27774887 2017
26
Do HDL and LDL subfractions play a role in atherosclerosis in end-stage renal disease (ESRD) patients? 38
27942970 2017
27
Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer. 38
26970778 2016
28
High density lipoprotein subfractions and paraoxonase 1 in children. 38
27262841 2016
29
Portulaca oleracea reduces triglyceridemia, cholesterolemia, and improves lecithin: cholesterol acyltransferase activity in rats fed enriched-cholesterol diet. 38
25442258 2014
30
Paraoxonase 1 and HDL subfractions in hypercholesterolemic children and adolescents. 38
26461330 2014
31
Huntington disease and Huntington disease-like in a case series from Brazil. 38
24102565 2014
32
Modified interferon-α subtypes production and chemokine networks in the thymus during acute simian immunodeficiency virus infection, impact on thymopoiesis. 38
24614087 2014
33
Comparison of plasma lipoprotein profiles and malondialdehyde between hyperlipidemia dogs with/without treatment. 38
24625120 2014
34
The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice. 38
24672716 2014
35
Genotype-phenotype analysis in inherited prion disease with eight octapeptide repeat insertional mutation. 38
24275071 2013
36
Huntington disease-like 2 (HDL2) in Venezuela: frequency and ethnic origin. 38
22971727 2013
37
Inborn errors of brain myelin formation. 38
23622380 2013
38
Genetic screening of Greek patients with Huntington’s disease phenocopies identifies an SCA8 expansion. 38
22297462 2012
39
In vitro lipid transfer between lipoproteins and midgut-diverticula in the spider Polybetes pythagoricus. 38
21889600 2011
40
Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs. 38
21327518 2011
41
HDL subfractions analysis: a new laboratory diagnostic assay for patients with cardiovascular diseases and dyslipoproteinemia. 38
21876506 2011
42
Huntington's disease look-alikes. 38
21496572 2011
43
[Differential diagnosis of chorea]. 38
19697886 2009
44
Heme-binding storage proteins in the Chelicerata. 38
19183556 2009
45
Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice. 38
18280133 2008
46
Huntington disease-like 2: the first patient with apparent European ancestry. 38
18341606 2008
47
Huntington's disease phenocopies are clinically and genetically heterogeneous. 38
18181206 2008
48
Huntington's disease phenocopy syndromes. 38
17992089 2007
49
The differential diagnosis of chorea. 38
18024776 2007
50
The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test. 38
17805246 2007

Variations for Huntington Disease-Like 1

ClinVar genetic disease variations for Huntington Disease-Like 1:

6 (show all 12)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 PRNP NM_000311.4(PRNP) NT expansion Pathogenic rs193922906 20:4680026-4680049 20:4699380-4699403
2 PRNP NM_000311.5(PRNP): c.598G> A (p.Glu200Lys) single nucleotide variant Pathogenic rs28933385 20:4680464-4680464 20:4699818-4699818
3 PRNP NM_000311.4(PRNP): c.593T> C (p.Phe198Ser) single nucleotide variant Pathogenic rs74315405 20:4680459-4680459 20:4699813-4699813
4 PRNP NM_000311.5(PRNP): c.628G> A (p.Val210Ile) single nucleotide variant Pathogenic rs74315407 20:4680494-4680494 20:4699848-4699848
5 PRNP NM_000311.5(PRNP): c.462G> A (p.Met154Ile) single nucleotide variant Uncertain significance 20:4680328-4680328 20:4699682-4699682
6 PRNP NM_000311.3(PRNP): c.204_227del24 (p.Pro84_Gln91del) short repeat Likely benign rs193922906 20:4680070-4680093 20:4699424-4699447
7 PRNP NM_000311.5(PRNP): c.160G> A (p.Gly54Ser) single nucleotide variant Likely benign rs763524380 20:4680026-4680026 20:4699380-4699380
8 PRNP NM_000311.5(PRNP): c.228C> T (p.Pro76=) single nucleotide variant Benign/Likely benign rs112637437 20:4680094-4680094 20:4699448-4699448
9 PRNP NM_000311.5(PRNP): c.246A> G (p.Gly82=) single nucleotide variant Benign rs62643364 20:4680112-4680112 20:4699466-4699466
10 PRNP NM_000311.5(PRNP): c.351A> G (p.Ala117=) single nucleotide variant Benign rs8124214 20:4680217-4680217 20:4699571-4699571
11 PRNP NM_000311.5(PRNP): c.246_269del (p.60_67PHGGGWGQ[3]) deletion Benign rs138688873 20:4680112-4680135 20:4699466-4699489
12 PRNP NM_000311.5(PRNP): c.512A> G (p.Asn171Ser) single nucleotide variant Benign rs16990018 20:4680378-4680378 20:4699732-4699732

Expression for Huntington Disease-Like 1

Search GEO for disease gene expression data for Huntington Disease-Like 1.

Pathways for Huntington Disease-Like 1

Pathways related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 APOE APOB APOA1
2
Show member pathways
11.88 APOE APOB APOA1
3
Show member pathways
11.83 APOE APOB APOA1
4
Show member pathways
11.79 CETP APOE APOB APOA1
5
Show member pathways
11.35 APOE APOB APOA1
6
Show member pathways
11.05 APOB APOA1
7
Show member pathways
11 CETP APOE APOB APOA1
8 10.64 APOB APOA1

GO Terms for Huntington Disease-Like 1

Cellular components related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.89 PRNP CETP APOE APOB APOA1
2 endoplasmic reticulum lumen GO:0005788 9.65 APOE APOB APOA1
3 early endosome GO:0005769 9.63 APOE APOB APOA1
4 high-density lipoprotein particle GO:0034364 9.54 CETP APOE APOA1
5 extracellular vesicle GO:1903561 9.51 APOE APOA1
6 very-low-density lipoprotein particle GO:0034361 9.5 APOE APOB APOA1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 APOE APOB
8 endocytic vesicle lumen GO:0071682 9.43 APOE APOB APOA1
9 discoidal high-density lipoprotein particle GO:0034365 9.4 APOE APOA1
10 low-density lipoprotein particle GO:0034362 9.33 APOE APOB APOA1
11 chylomicron GO:0042627 9.13 APOE APOB APOA1
12 intermediate-density lipoprotein particle GO:0034363 8.8 APOE APOB APOA1

Biological processes related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.95 CETP APOE APOB APOA1
2 post-translational protein modification GO:0043687 9.86 APOE APOB APOA1
3 cellular protein metabolic process GO:0044267 9.84 APOE APOB APOA1
4 receptor-mediated endocytosis GO:0006898 9.84 APOE APOB APOA1
5 lipid transport GO:0006869 9.8 CETP APOE APOB APOA1
6 steroid metabolic process GO:0008202 9.78 CETP APOE APOB APOA1
7 retinoid metabolic process GO:0001523 9.75 APOE APOB APOA1
8 triglyceride homeostasis GO:0070328 9.73 CETP APOE APOA1
9 triglyceride catabolic process GO:0019433 9.72 APOE APOB APOA1
10 cholesterol transport GO:0030301 9.71 CETP APOB APOA1
11 cholesterol homeostasis GO:0042632 9.71 CETP APOE APOB APOA1
12 lipoprotein metabolic process GO:0042157 9.7 APOE APOB APOA1
13 cholesterol efflux GO:0033344 9.69 APOE APOB APOA1
14 phospholipid transport GO:0015914 9.68 CETP APOA1
15 cholesterol biosynthetic process GO:0006695 9.68 APOE APOA1
16 lipid homeostasis GO:0055088 9.68 CETP APOE
17 triglyceride metabolic process GO:0006641 9.67 CETP APOE
18 long-term memory GO:0007616 9.67 PRNP APOE
19 artery morphogenesis GO:0048844 9.66 APOE APOB
20 regulation of neuronal synaptic plasticity GO:0048168 9.65 JPH3 APOE
21 positive regulation of lipid biosynthetic process GO:0046889 9.65 APOE APOA1
22 high-density lipoprotein particle assembly GO:0034380 9.64 APOE APOA1
23 phospholipid efflux GO:0033700 9.64 APOE APOA1
24 phospholipid homeostasis GO:0055091 9.63 CETP APOA1
25 negative regulation of long-term synaptic potentiation GO:1900272 9.63 PRNP APOE
26 reverse cholesterol transport GO:0043691 9.63 CETP APOE APOA1
27 negative regulation of amyloid-beta formation GO:1902430 9.62 PRNP APOE
28 high-density lipoprotein particle clearance GO:0034384 9.62 APOE APOA1
29 cholesterol metabolic process GO:0008203 9.62 CETP APOE APOB APOA1
30 positive regulation of cholesterol esterification GO:0010873 9.61 APOE APOA1
31 chylomicron remnant clearance GO:0034382 9.61 APOE APOB
32 high-density lipoprotein particle remodeling GO:0034375 9.61 CETP APOE APOA1
33 regulation of cholesterol transport GO:0032374 9.6 APOE APOA1
34 regulation of Cdc42 protein signal transduction GO:0032489 9.59 APOE APOA1
35 very-low-density lipoprotein particle clearance GO:0034447 9.58 APOE APOB
36 lipoprotein catabolic process GO:0042159 9.57 APOE APOB
37 low-density lipoprotein particle remodeling GO:0034374 9.54 CETP APOE APOB
38 chylomicron assembly GO:0034378 9.43 APOE APOB APOA1
39 very-low-density lipoprotein particle remodeling GO:0034372 9.33 CETP APOE APOA1
40 chylomicron remodeling GO:0034371 9.13 APOE APOB APOA1
41 lipoprotein biosynthetic process GO:0042158 8.8 APOE APOB APOA1

Molecular functions related to Huntington Disease-Like 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.61 APOE APOB APOA1
2 lipid binding GO:0008289 9.5 CETP APOE APOA1
3 phospholipid transporter activity GO:0005548 9.48 CETP APOA1
4 low-density lipoprotein particle receptor binding GO:0050750 9.46 APOE APOB
5 amyloid-beta binding GO:0001540 9.43 PRNP APOE APOA1
6 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.4 APOE APOA1
7 lipoprotein particle binding GO:0071813 9.37 APOE APOA1
8 cholesterol binding GO:0015485 9.33 CETP APOE APOA1
9 lipid transporter activity GO:0005319 9.26 CETP APOE APOB APOA1
10 cholesterol transporter activity GO:0017127 8.92 CETP APOE APOB APOA1

Sources for Huntington Disease-Like 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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