Hydatidiform Mole, Recurrent, 3 (HYDM3)

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OMIM 56 618431 OMIM Phenotypic Series 56 PS231090 MeSH 43 D006828

MedGen 41 CN258388 SNOMED-CT via HPO 68 15296000 258211005 8619003

OMIM : ⁵⁶ Hydatidiform mole is a human pregnancy with abnormal or no embryonic development and excessive trophoblastic proliferation. Partial hydatidiform moles have a triploid dispermic genome, with 2 sets of paternal chromosomes and 1 set of maternal chromosomes; complete hydatidiform moles have a diploid androgenetic genome with all chromosomes originating from 1 (monospermic) or 2 (dispermic) sperms, and no maternal chromosomes (summary by Nguyen et al., 2018). For a discussion of genetic heterogeneity of recurrent hydatidiform mole, see HYDM1 (231090). (618431)

MalaCards based summary : Hydatidiform Mole, Recurrent, 3, is also known as hydm3. An important gene associated with Hydatidiform Mole, Recurrent, 3 is MEI1 (Meiotic Double-Stranded Break Formation Protein 1). Affiliated tissues include uterus, and related phenotypes are infertility and hydatidiform mole

UniProtKB/Swiss-Prot : ⁷³ Hydatidiform mole, recurrent, 3: A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.

Clinical features from OMIM:

618431

Search Clinical Trials , NIH Clinical Center for Hydatidiform Mole, Recurrent, 3

Search GEO for disease gene expression data for Hydatidiform Mole, Recurrent, 3.