HYDM3
MCID: HYD067
MIFTS: 18
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Hydatidiform Mole, Recurrent, 3 (HYDM3)
Categories:
Cancer diseases, Fetal diseases, Genetic diseases, Rare diseases, Reproductive diseases
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MalaCards integrated aliases for Hydatidiform Mole, Recurrent, 3:Characteristics:OMIM®:57 (Updated 05-Mar-2021)
Inheritance:
autosomal recessive
Miscellaneous:
based on a report of 3 sisters and an unrelated woman (last curated may 2019) HPO:31Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases Cancer diseases Anatomical: Reproductive diseases |
OMIM® :
57
Hydatidiform mole is a human pregnancy with abnormal or no embryonic development and excessive trophoblastic proliferation. Partial hydatidiform moles have a triploid dispermic genome, with 2 sets of paternal chromosomes and 1 set of maternal chromosomes; complete hydatidiform moles have a diploid androgenetic genome with all chromosomes originating from 1 (monospermic) or 2 (dispermic) sperms, and no maternal chromosomes (summary by Nguyen et al., 2018).
For a discussion of genetic heterogeneity of recurrent hydatidiform mole, see HYDM1 (231090). (618431) (Updated 05-Mar-2021)
MalaCards based summary : Hydatidiform Mole, Recurrent, 3, is also known as hydm3. An important gene associated with Hydatidiform Mole, Recurrent, 3 is MEI1 (Meiotic Double-Stranded Break Formation Protein 1). Affiliated tissues include uterus, and related phenotypes are infertility and hydatidiform mole UniProtKB/Swiss-Prot : 73 Hydatidiform mole, recurrent, 3: A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. |
Diseases in the Recurrent Hydatidiform Mole family:
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Human phenotypes related to Hydatidiform Mole, Recurrent, 3:31
Symptoms via clinical synopsis from OMIM®:57 (Updated 05-Mar-2021)Clinical features from OMIM®:618431 (Updated 05-Mar-2021) |
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MalaCards organs/tissues related to Hydatidiform Mole, Recurrent, 3:40
Uterus
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Articles related to Hydatidiform Mole, Recurrent, 3:
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ClinVar genetic disease variations for Hydatidiform Mole, Recurrent, 3:6
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GEO
for disease gene expression data for Hydatidiform Mole, Recurrent, 3.
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