Aliases & Classifications for Hydrarthrosis

MalaCards integrated aliases for Hydrarthrosis:

Name: Hydrarthrosis 12 44 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:528
ICD9CM 35 719.08
MeSH 44 D006833
UMLS 72 C0158157 C1253936

Summaries for Hydrarthrosis

MalaCards based summary : Hydrarthrosis is related to palindromic rheumatism and synovitis, and has symptoms including arthralgia, edema and metatarsalgia. An important gene associated with Hydrarthrosis is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Methotrexate and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are homeostasis/metabolism and skeleton

Related Diseases for Hydrarthrosis

Diseases related to Hydrarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 palindromic rheumatism 30.1 PRTN3 MEFV IL1B
2 synovitis 29.9 MMP3 MMP13 IL1RN IL1B
3 osteoarthritis 28.9 MMP3 MMP13 IL1B ADAMTS5
4 arthritis 28.2 MMP3 MMP13 IL1RN IL1B ADAMTS5
5 intermittent hydrarthrosis 12.8
6 dysferlinopathy 10.5 MIP AQP1
7 cervical adenitis 10.4 MEFV IL1B
8 impaired renal function disease 10.4 AQP3 AQP1
9 familial cold autoinflammatory syndrome 1 10.4 MEFV IL1B
10 hypersensitivity reaction type iii disease 10.4 MEFV C4A
11 juvenile ankylosing spondylitis 10.3 MEFV IL1RN
12 diabetes insipidus, nephrogenic, autosomal 10.3 MIP AQP3 AQP1
13 corneal ulcer 10.3 MMP3 IL1B
14 pharyngitis 10.2 MEFV IL1B
15 pericardium disease 10.2 MEFV IL1RN
16 peritonitis 10.2 MEFV IL1B AQP1
17 brain edema 10.2 MIP IL1B AQP1
18 blau syndrome 10.2 MEFV IL1B
19 corneal edema 10.2 MMP3 IL1B
20 vulvar vestibulitis syndrome 10.2 IL1RN IL1B
21 schnitzler syndrome 10.1 IL1RN IL1B
22 osteosclerotic myeloma 10.1 IL1RN IL1B
23 meningococcemia 10.1 IL1RN IL1B
24 dermatitis herpetiformis, familial 10.1
25 multicentric reticulohistiocytosis 10.1
26 gout 10.1
27 urethritis 10.1
28 primary hypertrophic osteoarthropathy 10.1
29 rheumatic disease 10.1
30 enthesopathy 10.1
31 dermatitis 10.1
32 pustulosis of palm and sole 10.1
33 hemarthrosis 10.1
34 dermatitis herpetiformis 10.1
35 psoriasis 10.1
36 pustular psoriasis 10.1
37 rare systemic disease 10.1
38 familial calcium pyrophosphate deposition 10.1
39 overgrowth syndrome 10.1
40 hypersensitivity vasculitis 10.1 PRTN3 MEFV C4A
41 meniere disease 10.1 MIP AQP7 AQP3 AQP1
42 muckle-wells syndrome 10.0 MEFV IL1B
43 cinca syndrome 10.0 MEFV IL1RN IL1B
44 adult-onset still's disease 10.0 MEFV IL1RN IL1B
45 aphthous stomatitis 10.0 MEFV IL1RN IL1B
46 pericarditis 10.0 MEFV IL1RN IL1B
47 bone deterioration disease 10.0 MMP3 MMP13 IL1B
48 familial mediterranean fever 10.0 MEFV IL1RN IL1B
49 frozen shoulder 9.9 MMP3 IL1B ASIC3 ASIC2
50 anterior scleritis 9.9 PRTN3 IL1RN

Graphical network of the top 20 diseases related to Hydrarthrosis:



Diseases related to Hydrarthrosis

Symptoms & Phenotypes for Hydrarthrosis

UMLS symptoms related to Hydrarthrosis:


arthralgia, edema, metatarsalgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, painful swollen joints, effusion of joint, other specified sites

MGI Mouse Phenotypes related to Hydrarthrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 AQP1 AQP3 AQP7 AQP9 ASIC3 IL1B
2 skeleton MP:0005390 9.23 ADAMTS5 AQP1 AQP3 IL1B IL1RN MEFV

Drugs & Therapeutics for Hydrarthrosis

Drugs for Hydrarthrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved 1959-05-2, 59-05-2 126941
2
leucovorin Approved 58-05-9 143 6006
3
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
4 Folic Acid Antagonists
5 Vitamin B9
6 Nucleic Acid Synthesis Inhibitors
7 Vitamin B Complex
8 Immunosuppressive Agents
9 Folate
10 Dermatologic Agents
11 Immunologic Factors
12 Antimetabolites
13 Antimetabolites, Antineoplastic
14 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
2 Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis Completed NCT01314820
3 Clinical Trial for the Effects of Joint Effusion on Proprioception Completed NCT01060215
4 Ultrasound Guided Versus Landmark Guided Small & Medium Joint Arthrocentesis Recruiting NCT03327584
5 Characterizing Changes in Knee Joint Loading With Wearable Sensor Technology Following an Experimental Knee Joint Effusion Recruiting NCT03805464
6 Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis Not yet recruiting NCT04004962
7 Development and Validation of a Simple Diagnostic Tool Predictive of the Aseptic Character of Joint Effusion Not yet recruiting NCT03979937
8 A Randomized, Double-blind, Placebo-controlled Clinical Trial of Methotrexate (MTX) in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis Not yet recruiting NCT03815448 Methotrexate

Search NIH Clinical Center for Hydrarthrosis

Cochrane evidence based reviews: hydrarthrosis

Genetic Tests for Hydrarthrosis

Anatomical Context for Hydrarthrosis

MalaCards organs/tissues related to Hydrarthrosis:

41
Bone, Spinal Cord, Bone Marrow

Publications for Hydrarthrosis

Articles related to Hydrarthrosis:

(show top 50) (show all 136)
# Title Authors PMID Year
1
Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factor‑κB signaling in chondrocytes. 38
29901079 2018
2
ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. 38
29141196 2018
3
Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. 38
28986307 2018
4
Initiation Timing of Low-Intensity Pulsed Ultrasound Stimulation for Tendon-Bone Healing in a Rabbit Model. 38
27358283 2016
5
Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis. 38
24837400 2016
6
Successful Treatment of Intermittent Hydrarthrosis With Hydroxychloroquine. 38
26587859 2015
7
Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis. 38
26703073 2015
8
Arthroscopic Microfracture Technique for Cartilage Damage to the Lateral Condyle of the Tibia. 38
26345523 2015
9
[MRI characteristic of proximal femur bone marrow edema syndrome]. 38
25338444 2014
10
[Effect of acetazolamide on AQP1 and AQP3 expressions in fibroblast-like synoviocytes of rheumatoid arthritis]. 38
24200065 2013
11
Increased levels of matrix metalloproteinase-3 in the sera and synovial fluids of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: report of 2 cases. 38
22441965 2013
12
Anakinra for a refractory case of intermittent hydrarthrosis with a TRAPS-related gene mutation. 38
22887853 2013
13
[Physical examination of the knee after trauma]. 38
21447214 2011
14
TNF-alpha-induced aquaporin 9 in synoviocytes from patients with OA and RA. 38
20181673 2010
15
Expression of aquaporin 1 (AQP1) in human synovitis. 38
20149606 2010
16
Total knee arthroplasty in a spinal cord-injured patient: a case report. 38
19720574 2009
17
[Early clinical results of total knee arthroplasty with journey prosthesis]. 38
19817281 2009
18
[Treatment of valgus deformity by total knee arthroplasty with modified Ranawat soft tissue balance technique]. 38
19817282 2009
19
May some cases of intermittent hydrarthrosis represent an atypical form of calcium pyrophosphate dihydrate crystal deposition disease? Usefulness of mutational analysis of the MEFV gene. 38
17889261 2008
20
Bone bruise in magnetic resonance imaging strongly correlates with the production of joint effusion and with knee osteoarthritis. 38
18274849 2008
21
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. 38
17665427 2007
22
Association of intermittent hydrarthrosis with MEFV gene mutations. 38
16802374 2006
23
Clinical features of the posterior horn tear in the medial meniscus. 38
15133696 2004
24
Palindromic rheumatism and other relapsing arthritis. 38
15454124 2004
25
Successful therapy with low-dose colchicine in intermittent hydrarthrosis. 38
12595650 2003
26
Synovial hemangioma. Description of a case. 38
12847794 2002
27
Estimation of joint fluid volume in the knee joint of rabbits by measuring the endogenous calcium concentration. 38
12175108 2002
28
Multicentric reticulohistiocytosis with hydrarthrosis in both knee joints: disease stabilization with synovectomy, and medication with a steroid and low-dose methotrexate. 38
24383904 2002
29
[Efficacy of intra-articular injection of sodium hyaluronate in post-operation treatment of the knee]. 38
11826642 2002
30
[Clinical evaluation of high molecular hyaluronic acid (HA) on rheumatoid arthritic knees]. 38
15775288 2002
31
Analysis of the levels of endotoxin and β-d-glucan in the synovial fluid of hemodialysis patients. 38
24383774 2001
32
[Etiology and pathogenesis of osteochondrosis dissecans tali]. 38
11227348 2001
33
Rheologic changes in the synovial fluid of patients with gonarthritis induced by intraarticular infiltration of hyaluronic acid. 38
11447776 2001
34
[Clinical features of patients with osteoarthritic knees followed by development of rheumatoid arthritis]. 38
11021172 2000
35
Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. 38
11108572 2000
36
Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee. 38
10606382 1999
37
Analysis of synovial fluid components of hydrarthrosis in long-term hemodialysis patients. 38
10370156 1999
38
Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: relationship with disease activity in rheumatoid arthritis. 38
9858442 1998
39
Intermittent hydrarthrosis. 38
11273267 1998
40
[Hoffa's disease of the adipose pad: magnetic resonance versus surgical findings]. 38
9676203 1998
41
Common causes of knee effusions in spinal cord injury: a random study. 38
9558011 1998
42
Revision total knee arthroplasty after failed high tibial osteotomy. 38
9438088 1997
43
Mycoplasma fermentans, but not M penetrans, detected by PCR assays in synovium from patients with rheumatoid arthritis and other rheumatic disorders. 38
8943749 1996
44
Arthroscopic reconstruction of the anterior cruciate ligament with Leeds-Keio ligament in non-professional athletes. Results after a minimum 5 years' follow-up. 38
8819057 1996
45
Hydrarthrosis of the knee or ankle revealing metaphyseal stress fractures of the tibia. A report of 3 cases. 38
8523370 1995
46
Intra-articular use of tenoxicam in degenerative osteoarthritis of the knee joint. 38
7895896 1994
47
Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis. 38
11548232 1994
48
[Hydrarthrosis due to ciprofloxacin]. 38
8183011 1994
49
[Baker's cysts. A follow-up study after surgical therapy]. 38
8153647 1994
50
Significance of arthroscopy in children with knee joint injuries. 38
1498110 1992

Variations for Hydrarthrosis

Expression for Hydrarthrosis

Search GEO for disease gene expression data for Hydrarthrosis.

Pathways for Hydrarthrosis

Pathways related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 MIP ASIC3 ASIC2 AQP9 AQP7 AQP3
2 11.71 IL1RN IL1B C4A
3
Show member pathways
11.53 MMP3 IL1B ADAMTS5
4
Show member pathways
11.44 MIP AQP9 AQP7 AQP3 AQP1
5 11.18 MMP3 IL1RN IL1B

GO Terms for Hydrarthrosis

Cellular components related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.85 PRTN3 MIP IL1RN C4A ASIC3 ASIC2
2 integral component of plasma membrane GO:0005887 9.43 MIP ASIC3 ASIC2 AQP9 AQP7 AQP1
3 extracellular space GO:0005615 9.17 PRTN3 MMP3 MMP13 IL1RN IL1B C4A

Biological processes related to Hydrarthrosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.85 MIP AQP9 AQP7 AQP3 AQP1
2 inflammatory response GO:0006954 9.84 MEFV IL1RN IL1B C4A
3 proteolysis GO:0006508 9.81 PRTN3 MMP3 MMP13 ADAMTS5
4 cytokine-mediated signaling pathway GO:0019221 9.78 PRTN3 MMP3 IL1RN IL1B
5 extracellular matrix disassembly GO:0022617 9.61 MMP3 MMP13 ADAMTS5
6 odontogenesis GO:0042476 9.57 AQP3 AQP1
7 renal water homeostasis GO:0003091 9.56 AQP3 AQP1
8 cellular response to nitric oxide GO:0071732 9.52 MMP3 AQP1
9 cation transmembrane transport GO:0098655 9.5 ASIC3 ASIC2 AQP1
10 response to acidic pH GO:0010447 9.49 ASIC3 ASIC2
11 sensory perception of sour taste GO:0050915 9.4 ASIC3 ASIC2
12 detection of mechanical stimulus involved in sensory perception GO:0050974 9.37 ASIC3 ASIC2
13 collagen catabolic process GO:0030574 9.33 PRTN3 MMP3 MMP13
14 glycerol transport GO:0015793 9.26 AQP9 AQP7 AQP3 AQP1
15 response to vitamin D GO:0033280 9.25 AQP3
16 water transport GO:0006833 9.02 MIP AQP9 AQP7 AQP3 AQP1
17 excretion GO:0007588 8.96 AQP9

Molecular functions related to Hydrarthrosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.65 MMP3 MMP13 ADAMTS5
2 metalloendopeptidase activity GO:0004222 9.61 MMP3 MMP13 ADAMTS5
3 sodium channel activity GO:0005272 9.49 ASIC3 ASIC2
4 cation channel activity GO:0005261 9.46 ASIC3 ASIC2
5 interleukin-1 receptor binding GO:0005149 9.4 IL1RN IL1B
6 ligand-gated sodium channel activity GO:0015280 9.37 ASIC3 ASIC2
7 channel activity GO:0015267 9.35 MIP AQP9 AQP7 AQP3 AQP1
8 glycerol channel activity GO:0015254 9.33 AQP9 AQP7 AQP3
9 serine-type endopeptidase activity GO:0004252 9.32 PRTN3 MMP3
10 water transmembrane transporter activity GO:0005372 9.26 AQP9 AQP1
11 water channel activity GO:0015250 9.02 MIP AQP9 AQP7 AQP3 AQP1

Sources for Hydrarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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