Aliases & Classifications for Hydrarthrosis

MalaCards integrated aliases for Hydrarthrosis:

Name: Hydrarthrosis 12 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:528
ICD9CM 34 719.08
MeSH 43 D006833
UMLS 71 C0158157 C1253936

Summaries for Hydrarthrosis

MalaCards based summary : Hydrarthrosis is related to arthritis and intermittent hydrarthrosis, and has symptoms including arthralgia, edema and metatarsalgia. An important gene associated with Hydrarthrosis is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotype is skeleton.

Related Diseases for Hydrarthrosis

Diseases related to Hydrarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 arthritis 28.8 MMP3 MEFV ADAMTS5
2 intermittent hydrarthrosis 12.8
3 synovitis 10.4
4 bilateral renal aplasia 10.1 AQP9 AQP7
5 dermatitis herpetiformis, familial 10.1
6 palindromic rheumatism 10.1
7 multicentric reticulohistiocytosis 10.1
8 gout 10.1
9 urethritis 10.1
10 primary hypertrophic osteoarthropathy 10.1
11 rheumatic disease 10.1
12 enthesopathy 10.1
13 dermatitis 10.1
14 pustulosis of palm and sole 10.1
15 hemarthrosis 10.1
16 osteoarthritis 10.1
17 dermatitis herpetiformis 10.1
18 psoriasis 10.1
19 pustular psoriasis 10.1
20 rare systemic disease 10.1
21 familial calcium pyrophosphate deposition 10.1
22 overgrowth syndrome 10.1
23 dysferlinopathy 10.0 MIP AQP1
24 inappropriate adh syndrome 10.0 AQP3 AQP1
25 diabetes insipidus 9.9 MIP AQP3
26 priapism 9.9 MIP AQP1
27 brain edema 9.8 MIP AQP1
28 polyhydramnios 9.7 AQP9 AQP3 AQP1
29 inner ear disease 9.7 MIP AQP1
30 peritonitis 9.7 MEFV AQP1
31 constipation 9.7 AQP9 AQP7 AQP3
32 cartilage disease 9.6 MMP3 ADAMTS5
33 spondyloepimetaphyseal dysplasia, missouri type 9.6 MMP3 ADAMTS5
34 bone deterioration disease 9.5 MMP3 ADAMTS5
35 degenerative disc disease 9.5 MMP3 ADAMTS5
36 bone structure disease 9.5 MMP3 ADAMTS5
37 oligohydramnios 9.4 AQP9 AQP7 AQP3 AQP1
38 bullous keratopathy 9.4 MIP AQP9 AQP3 AQP1
39 impaired renal function disease 9.3 MIP AQP7 AQP3 AQP1
40 meniere disease 9.3 MIP AQP7 AQP3 AQP1
41 diabetes insipidus, nephrogenic, autosomal 9.3 MIP AQP7 AQP3 AQP1

Graphical network of the top 20 diseases related to Hydrarthrosis:



Diseases related to Hydrarthrosis

Symptoms & Phenotypes for Hydrarthrosis

UMLS symptoms related to Hydrarthrosis:


arthralgia, edema, metatarsalgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, painful swollen joints, effusion of joint, other specified sites

MGI Mouse Phenotypes related to Hydrarthrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.1 ADAMTS5 AQP1 AQP3 AQP9 MEFV MMP3

Drugs & Therapeutics for Hydrarthrosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis Completed NCT01314820
2 Clinical Trial for the Effects of Joint Effusion on Proprioception Completed NCT01060215
3 Ultrasound Guided Versus Landmark Guided Small & Medium Joint Arthrocentesis Recruiting NCT03327584
4 Characterizing Changes in Knee Joint Loading With Wearable Sensor Technology Following an Experimental Knee Joint Effusion Recruiting NCT03805464
5 Development and Validation of a Simple Diagnostic Tool Predictive of the Aseptic Character of Joint Effusion Not yet recruiting NCT03979937

Search NIH Clinical Center for Hydrarthrosis

Cochrane evidence based reviews: hydrarthrosis

Genetic Tests for Hydrarthrosis

Anatomical Context for Hydrarthrosis

MalaCards organs/tissues related to Hydrarthrosis:

40
Bone, Spinal Cord, Bone Marrow

Publications for Hydrarthrosis

Articles related to Hydrarthrosis:

(show top 50) (show all 136)
# Title Authors PMID Year
1
Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factor‑κB signaling in chondrocytes. 61
29901079 2018
2
ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. 61
29141196 2018
3
Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. 61
28986307 2018
4
Initiation Timing of Low-Intensity Pulsed Ultrasound Stimulation for Tendon-Bone Healing in a Rabbit Model. 61
27358283 2016
5
Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis. 61
24837400 2016
6
Successful Treatment of Intermittent Hydrarthrosis With Hydroxychloroquine. 61
26587859 2015
7
Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis. 61
26703073 2015
8
Arthroscopic Microfracture Technique for Cartilage Damage to the Lateral Condyle of the Tibia. 61
26345523 2015
9
[MRI characteristic of proximal femur bone marrow edema syndrome]. 61
25338444 2014
10
[Effect of acetazolamide on AQP1 and AQP3 expressions in fibroblast-like synoviocytes of rheumatoid arthritis]. 61
24200065 2013
11
Increased levels of matrix metalloproteinase-3 in the sera and synovial fluids of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: report of 2 cases. 61
22441965 2013
12
Anakinra for a refractory case of intermittent hydrarthrosis with a TRAPS-related gene mutation. 61
22887853 2013
13
[Physical examination of the knee after trauma]. 61
21447214 2011
14
TNF-alpha-induced aquaporin 9 in synoviocytes from patients with OA and RA. 61
20181673 2010
15
Expression of aquaporin 1 (AQP1) in human synovitis. 61
20149606 2010
16
Total knee arthroplasty in a spinal cord-injured patient: a case report. 61
19720574 2009
17
[Early clinical results of total knee arthroplasty with journey prosthesis]. 61
19817281 2009
18
[Treatment of valgus deformity by total knee arthroplasty with modified Ranawat soft tissue balance technique]. 61
19817282 2009
19
May some cases of intermittent hydrarthrosis represent an atypical form of calcium pyrophosphate dihydrate crystal deposition disease? Usefulness of mutational analysis of the MEFV gene. 61
17889261 2008
20
Bone bruise in magnetic resonance imaging strongly correlates with the production of joint effusion and with knee osteoarthritis. 61
18274849 2008
21
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. 61
17665427 2007
22
Association of intermittent hydrarthrosis with MEFV gene mutations. 61
16802374 2006
23
Clinical features of the posterior horn tear in the medial meniscus. 61
15133696 2004
24
Palindromic rheumatism and other relapsing arthritis. 61
15454124 2004
25
Successful therapy with low-dose colchicine in intermittent hydrarthrosis. 61
12595650 2003
26
Synovial hemangioma. Description of a case. 61
12847794 2002
27
Estimation of joint fluid volume in the knee joint of rabbits by measuring the endogenous calcium concentration. 61
12175108 2002
28
Multicentric reticulohistiocytosis with hydrarthrosis in both knee joints: disease stabilization with synovectomy, and medication with a steroid and low-dose methotrexate. 61
24383904 2002
29
[Efficacy of intra-articular injection of sodium hyaluronate in post-operation treatment of the knee]. 61
11826642 2002
30
[Clinical evaluation of high molecular hyaluronic acid (HA) on rheumatoid arthritic knees]. 61
15775288 2002
31
Analysis of the levels of endotoxin and β-d-glucan in the synovial fluid of hemodialysis patients. 61
24383774 2001
32
[Etiology and pathogenesis of osteochondrosis dissecans tali]. 61
11227348 2001
33
Rheologic changes in the synovial fluid of patients with gonarthritis induced by intraarticular infiltration of hyaluronic acid. 61
11447776 2001
34
[Clinical features of patients with osteoarthritic knees followed by development of rheumatoid arthritis]. 61
11021172 2000
35
Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. 61
11108572 2000
36
Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee. 61
10606382 1999
37
Analysis of synovial fluid components of hydrarthrosis in long-term hemodialysis patients. 61
10370156 1999
38
Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: relationship with disease activity in rheumatoid arthritis. 61
9858442 1998
39
Intermittent hydrarthrosis. 61
11273267 1998
40
[Hoffa's disease of the adipose pad: magnetic resonance versus surgical findings]. 61
9676203 1998
41
Common causes of knee effusions in spinal cord injury: a random study. 61
9558011 1998
42
Revision total knee arthroplasty after failed high tibial osteotomy. 61
9438088 1997
43
Mycoplasma fermentans, but not M penetrans, detected by PCR assays in synovium from patients with rheumatoid arthritis and other rheumatic disorders. 61
8943749 1996
44
Arthroscopic reconstruction of the anterior cruciate ligament with Leeds-Keio ligament in non-professional athletes. Results after a minimum 5 years' follow-up. 61
8819057 1996
45
Hydrarthrosis of the knee or ankle revealing metaphyseal stress fractures of the tibia. A report of 3 cases. 61
8523370 1995
46
Intra-articular use of tenoxicam in degenerative osteoarthritis of the knee joint. 61
7895896 1994
47
Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis. 61
11548232 1994
48
[Hydrarthrosis due to ciprofloxacin]. 61
8183011 1994
49
[Baker's cysts. A follow-up study after surgical therapy]. 61
8153647 1994
50
Significance of arthroscopy in children with knee joint injuries. 61
1498110 1992

Variations for Hydrarthrosis

Expression for Hydrarthrosis

Search GEO for disease gene expression data for Hydrarthrosis.

Pathways for Hydrarthrosis

Pathways related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 AQP9 AQP7 AQP3 AQP1
2
Show member pathways
12.48 MIP AQP9 AQP7 AQP3 AQP1
3
Show member pathways
11.44 MIP AQP9 AQP7 AQP3 AQP1
4 11.11 AQP9 AQP1
5 10.93 AQP9 AQP3

GO Terms for Hydrarthrosis

Cellular components related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.8 AQP9 AQP3 AQP1

Biological processes related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.65 MIP AQP9 AQP7 AQP3 AQP1
2 extracellular matrix disassembly GO:0022617 9.46 MMP3 ADAMTS5
3 cellular response to cAMP GO:0071320 9.43 AQP9 AQP1
4 odontogenesis GO:0042476 9.4 AQP3 AQP1
5 renal water homeostasis GO:0003091 9.37 AQP3 AQP1
6 urea transmembrane transport GO:0071918 9.33 AQP9 AQP7 AQP3
7 cellular response to nitric oxide GO:0071732 9.32 MMP3 AQP1
8 glycerol transport GO:0015793 9.26 AQP9 AQP7 AQP3 AQP1
9 water transport GO:0006833 9.02 MIP AQP9 AQP7 AQP3 AQP1

Molecular functions related to Hydrarthrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 urea transmembrane transporter activity GO:0015204 9.43 AQP9 AQP7 AQP3
2 metalloendopeptidase activity GO:0004222 9.37 MMP3 ADAMTS5
3 channel activity GO:0015267 9.35 MIP AQP9 AQP7 AQP3 AQP1
4 glycerol channel activity GO:0015254 9.33 AQP9 AQP7 AQP3
5 water transmembrane transporter activity GO:0005372 9.32 AQP9 AQP1
6 water channel activity GO:0015250 9.02 MIP AQP9 AQP7 AQP3 AQP1

Sources for Hydrarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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