Aliases & Classifications for Hydrarthrosis

MalaCards integrated aliases for Hydrarthrosis:

Name: Hydrarthrosis 12 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:528
ICD9CM 34 719.08
MeSH 43 D006833
UMLS 71 C0158157 C1253936

Summaries for Hydrarthrosis

MalaCards based summary : Hydrarthrosis is related to arthritis and intermittent hydrarthrosis, and has symptoms including arthralgia, edema and metatarsalgia. An important gene associated with Hydrarthrosis is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotype is skeleton.

Related Diseases for Hydrarthrosis

Diseases related to Hydrarthrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 43, show less)
# Related Disease Score Top Affiliating Genes
1 arthritis 28.8 MMP3 MEFV ADAMTS5
2 intermittent hydrarthrosis 12.8
3 synovitis 10.4
4 palindromic rheumatism 10.2
5 rheumatic disease 10.2
6 enthesopathy 10.2
7 bilateral renal aplasia 10.1 AQP9 AQP7
8 dermatitis herpetiformis, familial 10.1
9 multicentric reticulohistiocytosis 10.1
10 gout 10.1
11 urethritis 10.1
12 primary hypertrophic osteoarthropathy 10.1
13 dermatitis 10.1
14 periarthritis 10.1
15 pustulosis of palm and sole 10.1
16 hemarthrosis 10.1
17 osteoarthritis 10.1
18 dermatitis herpetiformis 10.1
19 psoriasis 10.1
20 pustular psoriasis 10.1
21 rare systemic disease 10.1
22 familial calcium pyrophosphate deposition 10.1
23 overgrowth syndrome 10.1
24 autoinflammatory syndrome 10.1
25 dysferlinopathy 10.0 MIP AQP1
26 inappropriate adh syndrome 10.0 AQP3 AQP1
27 diabetes insipidus 9.9 MIP AQP3
28 priapism 9.9 MIP AQP1
29 brain edema 9.8 MIP AQP1
30 polyhydramnios 9.7 AQP9 AQP3 AQP1
31 inner ear disease 9.7 MIP AQP1
32 peritonitis 9.7 MEFV AQP1
33 constipation 9.7 AQP9 AQP7 AQP3
34 cartilage disease 9.6 MMP3 ADAMTS5
35 spondyloepimetaphyseal dysplasia, missouri type 9.6 MMP3 ADAMTS5
36 bone deterioration disease 9.5 MMP3 ADAMTS5
37 degenerative disc disease 9.5 MMP3 ADAMTS5
38 bone structure disease 9.5 MMP3 ADAMTS5
39 oligohydramnios 9.4 AQP9 AQP7 AQP3 AQP1
40 bullous keratopathy 9.4 MIP AQP9 AQP3 AQP1
41 impaired renal function disease 9.3 MIP AQP7 AQP3 AQP1
42 meniere disease 9.3 MIP AQP7 AQP3 AQP1
43 diabetes insipidus, nephrogenic, autosomal 9.3 MIP AQP7 AQP3 AQP1

Graphical network of the top 20 diseases related to Hydrarthrosis:



Diseases related to Hydrarthrosis

Symptoms & Phenotypes for Hydrarthrosis

UMLS symptoms related to Hydrarthrosis:


arthralgia, edema, metatarsalgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, painful swollen joints, effusion of joint, other specified sites

MGI Mouse Phenotypes related to Hydrarthrosis:

45 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.1 ADAMTS5 AQP1 AQP3 AQP9 MEFV MMP3

Drugs & Therapeutics for Hydrarthrosis

Interventional clinical trials:

(showing 5, show less)
# Name Status NCT ID Phase Drugs
1 Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis Completed NCT01314820
2 Clinical Trial for the Effects of Joint Effusion on Proprioception Completed NCT01060215
3 Ultrasound Guided Versus Landmark Guided Small & Medium Joint Arthrocentesis Recruiting NCT03327584
4 Characterizing Changes in Knee Joint Loading With Wearable Sensor Technology Following an Experimental Knee Joint Effusion Recruiting NCT03805464
5 Development and Validation of a Simple Diagnostic Tool Predictive of the Aseptic Character of Joint Effusion Not yet recruiting NCT03979937

Search NIH Clinical Center for Hydrarthrosis

Cochrane evidence based reviews: hydrarthrosis

Genetic Tests for Hydrarthrosis

Anatomical Context for Hydrarthrosis

MalaCards organs/tissues related to Hydrarthrosis:

40
Bone, Spinal Cord, Bone Marrow, Brain

Publications for Hydrarthrosis

Articles related to Hydrarthrosis:

(showing 137, show less)
# Title Authors PMID Year
1
The evaluation of gene polymorphisms associated with autoinflammatory syndrome in patients with palindromic rheumatism complicated by intermittent hydrarthrosis. 61
31897954 2020
2
Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factor‑κB signaling in chondrocytes. 61
29901079 2018
3
ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity. 61
29141196 2018
4
Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. 61
28986307 2018
5
Initiation Timing of Low-Intensity Pulsed Ultrasound Stimulation for Tendon-Bone Healing in a Rabbit Model. 61
27358283 2016
6
Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis. 61
24837400 2016
7
Successful Treatment of Intermittent Hydrarthrosis With Hydroxychloroquine. 61
26587859 2015
8
Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis. 61
26703073 2015
9
Arthroscopic Microfracture Technique for Cartilage Damage to the Lateral Condyle of the Tibia. 61
26345523 2015
10
[MRI characteristic of proximal femur bone marrow edema syndrome]. 61
25338444 2014
11
[Effect of acetazolamide on AQP1 and AQP3 expressions in fibroblast-like synoviocytes of rheumatoid arthritis]. 61
24200065 2013
12
Increased levels of matrix metalloproteinase-3 in the sera and synovial fluids of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: report of 2 cases. 61
22441965 2013
13
Anakinra for a refractory case of intermittent hydrarthrosis with a TRAPS-related gene mutation. 61
22887853 2013
14
[Physical examination of the knee after trauma]. 61
21447214 2011
15
TNF-alpha-induced aquaporin 9 in synoviocytes from patients with OA and RA. 61
20181673 2010
16
Expression of aquaporin 1 (AQP1) in human synovitis. 61
20149606 2010
17
Total knee arthroplasty in a spinal cord-injured patient: a case report. 61
19720574 2009
18
[Early clinical results of total knee arthroplasty with journey prosthesis]. 61
19817281 2009
19
[Treatment of valgus deformity by total knee arthroplasty with modified Ranawat soft tissue balance technique]. 61
19817282 2009
20
May some cases of intermittent hydrarthrosis represent an atypical form of calcium pyrophosphate dihydrate crystal deposition disease? Usefulness of mutational analysis of the MEFV gene. 61
17889261 2008
21
Bone bruise in magnetic resonance imaging strongly correlates with the production of joint effusion and with knee osteoarthritis. 61
18274849 2008
22
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. 61
17665427 2007
23
Association of intermittent hydrarthrosis with MEFV gene mutations. 61
16802374 2006
24
Clinical features of the posterior horn tear in the medial meniscus. 61
15133696 2004
25
Palindromic rheumatism and other relapsing arthritis. 61
15454124 2004
26
Successful therapy with low-dose colchicine in intermittent hydrarthrosis. 61
12595650 2003
27
Synovial hemangioma. Description of a case. 61
12847794 2002
28
Estimation of joint fluid volume in the knee joint of rabbits by measuring the endogenous calcium concentration. 61
12175108 2002
29
Multicentric reticulohistiocytosis with hydrarthrosis in both knee joints: disease stabilization with synovectomy, and medication with a steroid and low-dose methotrexate. 61
24383904 2002
30
[Efficacy of intra-articular injection of sodium hyaluronate in post-operation treatment of the knee]. 61
11826642 2002
31
[Clinical evaluation of high molecular hyaluronic acid (HA) on rheumatoid arthritic knees]. 61
15775288 2002
32
Analysis of the levels of endotoxin and β-d-glucan in the synovial fluid of hemodialysis patients. 61
24383774 2001
33
[Etiology and pathogenesis of osteochondrosis dissecans tali]. 61
11227348 2001
34
Rheologic changes in the synovial fluid of patients with gonarthritis induced by intraarticular infiltration of hyaluronic acid. 61
11447776 2001
35
[Clinical features of patients with osteoarthritic knees followed by development of rheumatoid arthritis]. 61
11021172 2000
36
Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. 61
11108572 2000
37
Comparison between clinical evaluation and ultrasonography in detecting hydrarthrosis of the knee. 61
10606382 1999
38
Analysis of synovial fluid components of hydrarthrosis in long-term hemodialysis patients. 61
10370156 1999
39
Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: relationship with disease activity in rheumatoid arthritis. 61
9858442 1998
40
Intermittent hydrarthrosis. 61
11273267 1998
41
[Hoffa's disease of the adipose pad: magnetic resonance versus surgical findings]. 61
9676203 1998
42
Common causes of knee effusions in spinal cord injury: a random study. 61
9558011 1998
43
Revision total knee arthroplasty after failed high tibial osteotomy. 61
9438088 1997
44
Mycoplasma fermentans, but not M penetrans, detected by PCR assays in synovium from patients with rheumatoid arthritis and other rheumatic disorders. 61
8943749 1996
45
Arthroscopic reconstruction of the anterior cruciate ligament with Leeds-Keio ligament in non-professional athletes. Results after a minimum 5 years' follow-up. 61
8819057 1996
46
Hydrarthrosis of the knee or ankle revealing metaphyseal stress fractures of the tibia. A report of 3 cases. 61
8523370 1995
47
Intra-articular use of tenoxicam in degenerative osteoarthritis of the knee joint. 61
7895896 1994
48
Hyaluronan, cartilage destruction and hydrarthrosis in traumatic arthritis. 61
11548232 1994
49
[Hydrarthrosis due to ciprofloxacin]. 61
8183011 1994
50
[Baker's cysts. A follow-up study after surgical therapy]. 61
8153647 1994
51
Significance of arthroscopy in children with knee joint injuries. 61
1498110 1992
52
[Hydrarthrosis complicating a treatment with pefloxacine in a 14-year-old adolescent]. 61
2048945 1991
53
[Experimental evaluation of iotrolan as an arthrographic contrast medium--knee arthrography with iotrolan in rabbits]. 61
2087397 1990
54
The treatment of idiopathic and secondary hydrarthrosis of the knee by intra-articular Rifamycin SV. 61
2098221 1990
55
[Chronic instability of the knee]. 61
2602878 1989
56
Participation of synovial mast cells in intermittent hydrarthrosis. 61
2467680 1989
57
Treatment of hydrarthrosis of the knee with manual manipulation and herbs. 61
3246884 1988
58
Demonstration and characterization of a transient arthritis in rats following sensitization of synovial mast cells with antigen-specific IgE and parenteral challenge with specific antigen. 61
2457375 1988
59
[Intermittent hydrarthrosis in gout]. 61
3576826 1987
60
[Intermittent hydrarthrosis]. 61
3547551 1986
61
Calcium pyrophosphate crystals in intermittent hydrarthrosis. 61
3029370 1986
62
[Evaluation of the efficacy of orgotein in a series of patients with hydrarthrosis of the knee]. 61
3725124 1986
63
[Intermittent hydrarthrosis in patients with cerebral vegetative disorders]. 61
4079310 1985
64
[Another case of articular hydrops in dermatitis herpetiformis Duhring]. 61
6396988 1984
65
[Differential diagnosis of post-traumatic hydrarthrosis of the knee joint]. 61
6879842 1983
66
Rifamycin SV in the Treatment of Knee Synovitis. 61
24832010 1982
67
Popliteal cysts, femoral erosion and degenerative changes in the knee joint. 61
7076702 1982
68
A radio-isotopic investigation of the morphological and functional changes in pathological conditions of the synovial membrane of the knee joint. 61
7347736 1981
69
LE cells in intermittent hydrarthrosis. 61
6157396 1980
70
Clutton's Joints. 61
28223643 1979
71
[Intermittent hydrarthrosis]. 61
713451 1978
72
The distribution of proquazone and three of its metabolites in serum and synovial fluid. 61
278176 1978
73
[Auriculotherapy and pneumarthrocentesis in the treatment of hydrarthrosis of the knee]. 61
593600 1977
74
[A possible relationship between viral infection and hydrarthrosis]. 61
303592 1977
75
Arthrography with Amipaque (metrizamide) and other contrast media. A roentgenographic and histologic evaluation in rabbits. 61
1002407 1976
76
Treatment of persistent knee effusions with intra-articular radioactive gold. 61
1125918 1975
77
Hydroxyproline levels and collagenolytic activity in synovial fluids of patients with rheumatic diseases. 61
1135610 1975
78
[Hydrarthrosis caused by local stasis of varicose origin]. 61
4460058 1974
79
Periodic synoviosis (intermittent hydrarthrosis) with observations and studies on a patient. 61
4464498 1974
80
[Intermittent hydrarthrosis]. 61
5046427 1972
81
[Correlation between single synovial fluid components in hydrarthrosis of various etiology]. 61
4649104 1972
82
[Chemical synovectomy in chronic hydrarthrosis--intracapsular injection of osmic acid]. 61
5166426 1971
83
[Hydrarthrosis intermittens in a 21-year-old man following injury of the knee joint]. 61
5118715 1971
84
The treatment of persistent knee effusions with intra-articular radioactive gold: preliminary report. 61
5439327 1970
85
Tarsal hydrarthrosis in the horse: response to intra-articular injection of synthetic steroids. 61
5815590 1969
86
[Treatment of chronic hydrarthrosis]. 61
5814539 1969
87
[Therapy of chronic hydrarthrosis]. 61
5814540 1969
88
[Treatment of chronic hydrarthrosis]. 61
5814541 1969
89
[Hydrarthrosis as symptom of dermatitis herpetiformis]. 61
5723215 1968
90
Evaluation of intra-articular injection of synthetic steroids in tarsal hydrarthrosis in cattle. 61
5691642 1968
91
Tarsal hydrarthrosis (bog spavin) in the horse: blood, serum, and synovial fluid findings. 61
5688981 1968
92
Intra-articular injection of 6 alpha-methyl, 17 alpha-hydroxyprogesterone acetate in tarsal hydrarthrosis (bog spavin) in the horse. 61
5624181 1967
93
Characteristics of blood, serum, and synovial effusions in cattle with tarsal hydrarthrosis. 61
6069486 1967
94
Therapeutic management of tarsal hydrarthrosis (bog spavin) in the horse by intra-articular injection of prednisolone. 61
6068578 1967
95
[Colloidal Au-198 in the treatment of hydrarthrosis in rheumatoid polyarthritis]. 61
6073749 1967
96
[Study of enzyme therapy for hydrarthrosis]. 61
6007157 1966
97
[Clinical considerations on a case of pachydermoperiostosis with hydrarthrosis of the knee]. 61
5974352 1966
98
[INTERMITTENT HYDRARTHROSIS TREATED WITH OXYPHENBUTAZONE]. 61
14257980 1964
99
Acute Cervical Hydrarthrosis. 61
19790510 1964
100
SYPHILITIC HYDRARTHROSIS. 61
14075738 1963
101
[Posttraumatic recurring hydrarthrosis of the knee. (Anatomo-pathological, clinical and medicolegal considerations)]. 61
14014293 1963
102
[Diagnosis of a hydrarthrosis of the knee]. 61
14463317 1961
103
[Massive spongiform pustulosis with hydrarthrosis of the knee: pustular psoriasis or Reiter's syndrome?]. 61
13920188 1961
104
[New etiopathogenetic views in intermittent hydrarthrosis]. 61
13882148 1961
105
[Hydrarthrosis of the knee]. 61
13833044 1960
106
[Hydrarthrosis of the knee and its etiological problems]. 61
13858584 1960
107
[The value of electrophoresis in the examination of hydrarthrosis]. 61
13781248 1960
108
[Hydrarthrosis during edemas and vascular disorders of the lower limbs]. 61
14416893 1959
109
[Intermittent rheumatism. Palindromic rheumatism. Intermittent hydrarthrosis. Allergic rheumatism]. 61
14439364 1959
110
Intermittent hydrarthrosis; periodic benign synovitis. 61
13567199 1958
111
[Demonstration: periodic hydrarthrosis]. 61
13485862 1957
112
Intermittent hydrarthrosis. 61
13383213 1957
113
[Intermittent hydrarthrosis; etiology & pathogenesis, concept & nosological significance]. 61
13479243 1957
114
[Intra-articular hydrocortisone in post-traumatic hydrarthrosis of the knee]. 61
13408123 1956
115
[Teaching of joint puncture in hydrarthrosis of knee]. 61
13391025 1956
116
Periodic benign synovitis; idiopathic intermittent hydrarthrosis. 61
13367081 1956
117
[Essential hydrarthrosis]. 61
13421478 1956
118
[Intermittent hydrarthrosis]. 61
13379709 1956
119
[Periodic hydrarthrosis developing during remission of a case of chronic evolutive polyarthritis]. 61
13311184 1956
120
Hodgkin's disease presenting as hydrarthrosis of knee. 61
14378634 1955
121
Intermittent hydrarthrosis. 61
14372871 1955
122
[Periodic or intermittent hydrarthrosis]. 61
14381137 1955
123
[Surgical treatment of chronic hydrarthrosis of the knee: fenestration of the capsule]. 61
13132698 1953
124
Intermittent hydrarthrosis. 61
14933539 1952
125
[Polyalgic syndrome and hydrarthrosis of the knee, urethritis due to organism L., aureomycin therapy, cure]. 61
14921488 1951
126
[Tuberculous hydrarthrosis of the knee and calcareous spots in the tuberosities of the epiphyses]. 61
14884946 1951
127
[Traumatic hydrarthrosis or hemarthrosis of the temporomandibular joint with homolateral molar gap]. 61
15444083 1951
128
[Case of hydrarthrosis of the knee]. 61
14865617 1951
129
[Chronic bilateral hydrarthrosis of the knees with false diagnosis of Recklinghausen's "evolutive nevomatosis"]. 61
14895180 1951
130
[Hydrarthrosis in rheumatology]. 61
15438211 1950
131
[Treatment of hydrarthrosis]. 61
15427796 1950
132
[Recent conference at Dax on non-tuberculous hydrarthrosis of the knee]. 61
15411564 1950
133
Intermittent hydrarthrosis; two cases. 61
15390577 1949
134
The roentgenographic appearance of temporomandibular hydrarthrosis. 61
21018447 1946
135
Idiopathic Hydrarthrosis. 61
19988486 1932
136
Intermittent Hydrarthrosis: (Hydrops Intermittens Articulorum). 61
21433466 1930
137
Chronic Hydrarthrosis. 61
19976537 1913

Variations for Hydrarthrosis

Expression for Hydrarthrosis

Search GEO for disease gene expression data for Hydrarthrosis.

Pathways for Hydrarthrosis

Pathways related to Hydrarthrosis according to GeneCards Suite gene sharing:

(showing 5, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 AQP9 AQP7 AQP3 AQP1
2
Show member pathways
12.48 MIP AQP9 AQP7 AQP3 AQP1
3
Show member pathways
11.44 MIP AQP9 AQP7 AQP3 AQP1
4 11.11 AQP9 AQP1
5 10.93 AQP9 AQP3

GO Terms for Hydrarthrosis

Cellular components related to Hydrarthrosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 8.8 AQP9 AQP3 AQP1

Biological processes related to Hydrarthrosis according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.65 MIP AQP9 AQP7 AQP3 AQP1
2 extracellular matrix disassembly GO:0022617 9.46 MMP3 ADAMTS5
3 cellular response to cAMP GO:0071320 9.43 AQP9 AQP1
4 odontogenesis GO:0042476 9.4 AQP3 AQP1
5 renal water homeostasis GO:0003091 9.37 AQP3 AQP1
6 urea transmembrane transport GO:0071918 9.33 AQP9 AQP7 AQP3
7 cellular response to nitric oxide GO:0071732 9.32 MMP3 AQP1
8 glycerol transport GO:0015793 9.26 AQP9 AQP7 AQP3 AQP1
9 water transport GO:0006833 9.02 MIP AQP9 AQP7 AQP3 AQP1

Molecular functions related to Hydrarthrosis according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 urea transmembrane transporter activity GO:0015204 9.43 AQP9 AQP7 AQP3
2 metalloendopeptidase activity GO:0004222 9.37 MMP3 ADAMTS5
3 channel activity GO:0015267 9.35 MIP AQP9 AQP7 AQP3 AQP1
4 glycerol channel activity GO:0015254 9.33 AQP9 AQP7 AQP3
5 water transmembrane transporter activity GO:0005372 9.32 AQP9 AQP1
6 water channel activity GO:0015250 9.02 MIP AQP9 AQP7 AQP3 AQP1

Sources for Hydrarthrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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32 ICD10
33 ICD10 via Orphanet
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63 QIAGEN
68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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