Aliases & Classifications for Hydrocele

MalaCards integrated aliases for Hydrocele:

Name: Hydrocele 12 55 15
Testicular Hydrocele 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9912
ICD10 33 N43.3
UMLS 73 C1720771

Summaries for Hydrocele

MalaCards based summary : Hydrocele, also known as testicular hydrocele, is related to testicular seminoma and lymphangioma, and has symptoms including pain in scrotum An important gene associated with Hydrocele is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are TGF-Beta Pathway and Integrin Pathway. The drugs Methylene blue and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include testis, kidney and colon, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 A hydrocele is an accumulation of serous fluid in a body cavity. A hydrocele testis is the accumulation... more...

Related Diseases for Hydrocele

Diseases related to Hydrocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 testicular seminoma 31.8 AFP CGA
2 lymphangioma 29.7 FLT4 VEGFA
3 infected hydrocele 12.4
4 filarial elephantiasis 11.6
5 elephantiasis 11.4
6 lymphedema 11.4
7 irons bhan syndrome 11.1
8 lymphedema, hereditary, ia 11.0
9 infantile spasms broad thumbs 11.0
10 spermatocele 10.8
11 inguinal hernia 10.6
12 filariasis 10.4
13 degos 'en cocarde' erythrokeratoderma 10.2
14 cryptorchidism, unilateral or bilateral 10.2
15 varicocele 10.2
16 ovarian mixed germ cell neoplasm 10.2 AFP CGA
17 polyembryoma 10.2 AFP CGA
18 sacrococcygeal teratoma 10.2 AFP CGA
19 mixed germ cell tumor 10.2 AFP CGA
20 triploidy 10.2 AFP CGA
21 ovarian cyst 10.2 AFP VEGFA
22 chromosomal triplication 10.2 AFP CGA
23 orofaciodigital syndrome viii 10.2 AFP CGA
24 lymphatic malformations 10.1 FLT4 PKD2
25 telangiectasis 10.1 AFP VEGFA
26 hemifacial spasm 10.1 FLT4 VEGFA
27 testicular torsion 10.1
28 hydronephrosis 10.1
29 macular retinal edema 10.1 ICAM1 VEGFA
30 peliosis hepatis 10.1 AFP ITGA4 VEGFA
31 chronic venous insufficiency 10.1 ICAM1 ITGA4
32 critical limb ischemia 10.1 SELE VEGFA
33 venous insufficiency 10.1 ICAM1 ITGA4
34 heterophyiasis 10.0 ICAM1 SELE
35 lymphocytic vasculitis 10.0 ICAM1 SELE
36 chylothorax, congenital 10.0 FLT4 ITGB1
37 hymenolepiasis 10.0 ICAM1 SELE
38 plummer's disease 10.0 ICAM1 SELE
39 subendocardial myocardial infarction 10.0 ICAM1 SELE
40 rheumatoid vasculitis 10.0 ICAM1 SELE
41 hypersensitivity reaction type iii disease 10.0 ICAM1 SELE
42 leukocyte adhesion deficiency, type i 10.0 ICAM1 SELE
43 hydrocephalus 10.0
44 cystadenoma 10.0
45 rhabdomyosarcoma 10.0
46 epididymitis 10.0
47 diabetic macular edema 10.0 ICAM1 VEGFA
48 pustulosis palmaris et plantaris 10.0 ITGB1 SELE
49 tubular adenocarcinoma 10.0 AFP ESR1
50 reproductive organ benign neoplasm 10.0 AFP ESR1

Graphical network of the top 20 diseases related to Hydrocele:



Diseases related to Hydrocele

Symptoms & Phenotypes for Hydrocele

UMLS symptoms related to Hydrocele:


pain in scrotum

MGI Mouse Phenotypes related to Hydrocele:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ESR1 FLT4 ICAM1 ITGA3 ITGA4 ITGB1
2 homeostasis/metabolism MP:0005376 10.16 AFP CGA ESR1 FLT4 ICAM1 ITGA3
3 cellular MP:0005384 10.15 ESR1 ICAM1 ITGA3 ITGA4 ITGB1 PKD2
4 growth/size/body region MP:0005378 10.15 CGA ESR1 FLT4 ICAM1 ITGA3 ITGB1
5 endocrine/exocrine gland MP:0005379 10.11 AFP CGA ESR1 ICAM1 ITGA3 ITGB1
6 immune system MP:0005387 10.09 ESR1 FLT4 ICAM1 ITGA3 ITGA4 ITGB1
7 digestive/alimentary MP:0005381 10.08 ESR1 FLT4 ICAM1 ITGA3 ITGB1 PKD2
8 embryo MP:0005380 10.07 ESR1 FLT4 ITGA3 ITGA4 ITGB1 PKD2
9 hematopoietic system MP:0005397 10.02 ESR1 ICAM1 ITGA4 ITGB1 PKD2 SELE
10 mortality/aging MP:0010768 10.02 AFP ESR1 FLT4 ICAM1 ITGA3 ITGA4
11 integument MP:0010771 9.95 ESR1 FLT4 ICAM1 ITGA3 ITGB1 SELE
12 liver/biliary system MP:0005370 9.91 AFP ESR1 FLT4 ITGB1 PKD2 SELE
13 neoplasm MP:0002006 9.73 AFP ESR1 ICAM1 ITGA3 ITGB1 VEGFA
14 normal MP:0002873 9.63 ESR1 FLT4 ITGB1 PKD2 SELE VEGFA
15 renal/urinary system MP:0005367 9.35 ESR1 ITGA3 ITGB1 PKD2 VEGFA
16 respiratory system MP:0005388 9.1 ESR1 ITGA3 ITGB1 PKD2 SELE VEGFA

Drugs & Therapeutics for Hydrocele

Drugs for Hydrocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 2 61-73-4
2
Clonidine Approved Phase 2 4205-90-7 2803
3
Ropivacaine Approved Phase 2,Not Applicable 84057-95-4 175805 71273
4 Central Nervous System Depressants Phase 2,Not Applicable
5 Anesthetics, Local Phase 2,Not Applicable
6 Anesthetics Phase 2,Not Applicable
7 Peripheral Nervous System Agents Phase 2,Not Applicable
8 Analgesics Phase 2,Not Applicable
9 Sympatholytics Phase 2
10 Adrenergic alpha-Agonists Phase 2
11 Antihypertensive Agents Phase 2
12 Adrenergic alpha-2 Receptor Agonists Phase 2
13 Adrenergic Agents Phase 2
14 Autonomic Agents Phase 2
15 Adrenergic Agonists Phase 2
16 Neurotransmitter Agents Phase 2
17
Polidocanol Approved Not Applicable 9002-92-0
18
Levobupivacaine Approved, Investigational Not Applicable 27262-47-1 92253
19
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
20
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
21
Albendazole Approved, Vet_approved 54965-21-8 2082
22
Ibuprofen Approved Not Applicable 15687-27-1 3672
23
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
24 Pharmaceutical Solutions Not Applicable
25 Follicle Stimulating Hormone
26 Androgens
27 Hormones
28 Antiparasitic Agents
29 Anti-Infective Agents
30 Lipoxygenase Inhibitors
31 Anthelmintics
32 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
33 Narcotics Not Applicable
34 Analgesics, Opioid Not Applicable
35 Antirheumatic Agents Not Applicable
36 Anti-Inflammatory Agents Not Applicable
37 Cyclooxygenase Inhibitors Not Applicable
38 Analgesics, Non-Narcotic Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Laparoscopic Inguinal Hernia Repair in Infancy and Childhood Unknown status NCT02239185 Phase 3
2 Dye Assisted Lymphatic Sparing Subinguinal Varicocelectomy Completed NCT01259258 Phase 2
3 The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children Completed NCT00130091 Phase 2 clonidine
4 Lord´s Procedure Versus Sclerotherapy for Testicular Hydrocele; a Randomized Controlled Study Unknown status NCT02082613 Not Applicable
5 Transversus Abdominis Plane Block in Pediatrics: Volume or Concentration ? Unknown status NCT02064088 Not Applicable Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group;Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
6 Outcomes of Intra-Cytoplasmic Sperm Injection in Infertile Men With Non-tense Vaginal Hydrocele Completed NCT03532386
7 Assessing the Rates of Major Complications in Combined Mini-incision Microscopic Varicocelectomy Completed NCT02092311 Not Applicable
8 A Comparison of Testicular Volume and Blood Flow in Patients With Inguinal Hernia, Hydrocele, and Cord Cyst Completed NCT03033381 Not Applicable
9 Study of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Surgery Completed NCT01698268 Not Applicable
10 Dominican Republic Mission Cost Analysis Completed NCT01872364
11 Trial of Laparoscopic Compared to Open Inguinal Hernia Repair in Children Younger Than 3 Years Completed NCT00716768 Not Applicable
12 The Caudal Space in Children: Ultrasound Evaluation Completed NCT01896076
13 Visual Guidelines and Tutoring in Pediatric Urological Surgery Completed NCT02040389 Not Applicable
14 Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia Recruiting NCT03683745
15 Does Benign Prostatic Obstruction Cause Hypertension? Recruiting NCT02347436
16 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575
17 Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG Recruiting NCT03268252
18 Interactive Perioperative Teaching Platform (IPTP) Recruiting NCT03677453 Not Applicable
19 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
20 Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery Recruiting NCT02603848 Not Applicable Ibuprofen;Morphine
21 The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study Active, not recruiting NCT01757548 Not Applicable
22 Opioid Use, Storage, and Disposal Among Pediatric Patients After Surgery Enrolling by invitation NCT03575377 Not Applicable
23 Hernia Exploration oR Not In Infants Analysis Not yet recruiting NCT03623893 Not Applicable
24 Comparing Ilioinguinal Single-shot and Three-layer Blocks Terminated NCT01625780 Not Applicable

Search NIH Clinical Center for Hydrocele

Genetic Tests for Hydrocele

Anatomical Context for Hydrocele

MalaCards organs/tissues related to Hydrocele:

41
Testis, Kidney, Colon, Liver, Heart, Prostate, Pancreas

Publications for Hydrocele

Articles related to Hydrocele:

(show top 50) (show all 757)
# Title Authors Year
1
Re: MicroRNA miR-371a-3p-A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 29677902 )
2018
2
A case of giant hemorrhagic hydrocele testis. ( 29556473 )
2018
3
Not a Hydrocele! ( 29502879 )
2018
4
Shear wave elastography evaluation of testes with non-communicating hydrocele in infants and toddlers: AA preliminary study. ( 29724465 )
2018
5
Unusual Cause of Acute Scrotal Pain-Inflammatory Noncommunicating Hydrocele: A Pediatric Case Report. ( 29560001 )
2018
6
Malignant hydrocele: a rare manifestation of peritoneal carcinomatosis of colorectal origin as a transcoelomic spread into the scrotum - case report and literature overview. ( 29463171 )
2018
7
Microscopic subinguinal varicocelectomy in 100 consecutive cases: Spermatic cord vascular anatomy, recurrence and hydrocele outcome analysis. ( 29713549 )
2018
8
Müllerian carcinosarcoma with neuroendocrine differentiation arising in hydrocele of the canal of Nuck. ( 30198090 )
2018
9
Infected hydrocele. ( 30029966 )
2018
10
Effectiveness of Laparoscopy in the Treatment of Pediatric Hydrocele: A Systematic Review. ( 30063415 )
2018
11
Choroid Plexus Hyperplasia with Intractable Ascites and a Resulting Communicating Hydrocele following Shunt Operation for Hydrocephalus. ( 30157489 )
2018
12
A challenging abdomino-scrotal hydrocele-successful resolution with the help of interventional radiology guided sclerosis. ( 30214710 )
2018
13
Tunica Vaginalis Thickening, Hemorrhagic Infiltration and Inflammatory Changes in 8 Children with Primary Hydrocele; Reactive Mesothelial Hyperplasia? A Prospective Clinical Study. ( 30216181 )
2018
14
Re: Ascending Testis after Repair of Pediatric Inguinal Hernia and Hydrocele: A Misunderstood Operative Complication. ( 30227561 )
2018
15
Meconial hydrocele as first sign of acute intestinal perforation in a preterm baby. ( 30269084 )
2018
16
Cerebrospinal fluid hydrocele caused by scrotal migration of a ventriculoperitoneal shunt. ( 30317190 )
2018
17
Hydrocelectomy via scrotal incision is a valuable alternative to the traditional inguinal approach for hydrocele treatment in boys. ( 30402575 )
2018
18
Hydrocele Due to Wuchereria bancrofti Infection. ( 30449772 )
2018
19
Canal of Nuck Hydrocele: Diagnosis and Treatment of a Rare Inguinal Pathology. ( 30454530 )
2018
20
Comparison of recurrence and postoperative complications between 3 different techniques for surgical repair of idiopathic hydrocele. ( 30552941 )
2018
21
Pediatric genital lymphedema with recurrent hydrocele and late-onset secondary skin changes. ( 27978613 )
2017
22
Learning Curves for Laparoscopic Repair of Inguinal Hernia and Communicating Hydrocele in Children. ( 29021976 )
2017
23
A Rare Cause of Recurrent Vaginal Hydrocele: Herniating Mesenteric Hydatid Cyst. ( 28979358 )
2017
24
A Rare Case Report of a Paratesticular Fibrous Pseudotumor Mimicking a Hydrocele. ( 29057177 )
2017
25
Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulinA G4-related disease. ( 28809065 )
2017
26
A comparison of preoperative and postoperative testicular volume and blood flow in patients with inguinal hernia, hydrocele, and cord cyst: A prospective cohort study. ( 28523038 )
2017
27
Persistent Mullerian Duct Syndrome Presenting in an Incarcerated Recurrent Inguinal Hernia with Hydrocele. ( 28331809 )
2017
28
Hydrocele with a surprise: Malignant mesothelioma of the tunica vaginalis - Case report and review of literature. ( 28216946 )
2017
29
Hydrocele Caused by Peritoneal Fluid Leakage Through Inguinal Canal. ( 28512168 )
2017
30
A systematic review and meta-analysis concerning single-site laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. ( 28389795 )
2017
31
Migration of a ventriculoperitoneal shunt catheter through the processus vaginalis in infants: how serious inguinal hernia and hydrocele might be. ( 28616670 )
2017
32
Current practice regarding timing of patent processus vaginalis ligation for idiopathic hydrocele in young boys: a survey of UK surgeons. ( 28424863 )
2017
33
Efficacy of the traditional Japanese medicine goreisan for the resolution of spermatic cord hydrocele in children. ( 28710555 )
2017
34
Bilateral hydrocele. Uncommon clinical presentation of primary testicular lymphoma in the elderly. ( 28383626 )
2017
35
Methylene blue dye for identification of processus vaginalis during hydrocele repair: experience in a teaching hospital. ( 28176510 )
2017
36
Hydrocele of the canal of Nuck presenting as a sausage-shaped mass. ( 28978588 )
2017
37
Adolescent Hydrocele Carrying a Surprise: A Case of Papillary Cystadenoma of the Epididymis. ( 29154985 )
2017
38
Management of Abdomino-scrotal hydrocele (ASH)/Scrotal-inguino-retroperitoneal (SIR) hydrocele in a renal transplant patient. ( 29423145 )
2017
39
A comparison between totally laparoscopic hydrocelectomy and scrotal incision hydrocelectomy with laparoscopic high ligation for pediatric cord hydrocele. ( 28493163 )
2017
40
Laparoscopic Treatment of Hydrocele of the Canal of Nuck in Pediatric Patients. ( 29076118 )
2017
41
Editorial Comment to Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulin G4-related disease. ( 28809054 )
2017
42
Exploration Of The Contralateral Groin In Paediatric Inguinal Hernia Or Hydrocele Based On Ultrasound Findings - Is It Justified? ( 28712167 )
2017
43
Abdominoscrotal hydrocele in an infant boy. ( 28551604 )
2017
44
Endometriosis-associated hydrocele of the canal of Nuck with immunohistochemical confirmation: a case report. ( 29262869 )
2017
45
The role of transforming growth factor beta 1 in communicating and non-communicating hydrocele. ( 27146503 )
2016
46
Congenital hernias and hydrocele: Importance of age. ( 27251527 )
2016
47
Novel Surgical Approach to Giant Abdominoscrotal Hydrocele - Video. ( 27614118 )
2016
48
Hydrocele of the Canal of Nuck (Female Hydrocele): A Rare Differential for Inguino-Labial Swelling. ( 27042529 )
2016
49
Mesothelioma of the tunica vaginalis in a patient with giant hydrocele. ( 26929469 )
2016
50
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016

Variations for Hydrocele

Expression for Hydrocele

Search GEO for disease gene expression data for Hydrocele.

Pathways for Hydrocele

Pathways related to Hydrocele according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 FLT4 ICAM1 ITGA3 ITGA4 ITGB1 VEGFA
2
Show member pathways
13.18 CGA ICAM1 ITGA3 ITGA4 ITGB1 VEGFA
3
Show member pathways
13.16 ITGA3 ITGA4 ITGB1 SELE VEGFA
4
Show member pathways
12.76 FLT4 ITGA3 ITGA4 ITGB1 VEGFA
5
Show member pathways
12.73 CGA ICAM1 ITGA4 VEGFA
6
Show member pathways
12.64 ESR1 ITGA3 ITGA4 ITGB1
7
Show member pathways
12.64 FLT4 ITGA3 ITGA4 ITGB1 VEGFA
8
Show member pathways
12.59 ICAM1 ITGA3 ITGA4 ITGB1
9 12.55 ESR1 FLT4 ITGA3 ITGB1 VEGFA
10
Show member pathways
12.47 ICAM1 ITGA4 ITGB1 VEGFA
11
Show member pathways
12.24 FLT4 ITGA3 ITGA4 ITGB1
12
Show member pathways
12.18 ESR1 ICAM1 SELE VEGFA
13 12.16 ESR1 ITGB1 VEGFA
14
Show member pathways
12.08 ICAM1 ITGA3 ITGA4 ITGB1
15
Show member pathways
12.07 ITGA3 ITGA4 ITGB1
16
Show member pathways
12 FLT4 ITGA3 ITGA4 ITGB1
17
Show member pathways
11.96 ITGA3 ITGA4 ITGB1
18 11.94 ICAM1 SELE VEGFA
19 11.92 ICAM1 ITGA4 ITGB1
20 11.9 AFP ITGB1 VEGFA
21
Show member pathways
11.88 ITGA3 ITGA4 ITGB1 SELE
22 11.86 ICAM1 ITGA4 ITGB1
23 11.82 ITGA3 ITGA4 ITGB1
24 11.82 FLT4 ITGA3 ITGA4 ITGB1
25 11.81 ICAM1 ITGB1 VEGFA
26 11.73 ICAM1 SELE VEGFA
27
Show member pathways
11.69 CGA ESR1 VEGFA
28 11.64 ITGA3 ITGA4 ITGB1
29
Show member pathways
11.63 ICAM1 ITGA3 ITGA4 ITGB1
30 11.5 ITGA3 ITGA4 ITGB1
31
Show member pathways
11.43 ICAM1 SELE VEGFA
32 11.42 ICAM1 ITGA4 ITGB1 SELE
33 11.39 ITGA3 ITGA4 ITGB1
34 11.23 ICAM1 SELE
35 11.22 ICAM1 ITGA4 ITGB1
36 11.14 ITGA3 ITGB1
37 11.09 ITGA3 ITGB1
38 11.02 FLT4 ITGB1
39 11.02 ITGA3 ITGB1 SELE
40 10.87 FLT4 ITGA3 ITGA4 ITGB1
41 10.84 AFP CGA ICAM1 SELE
42
Show member pathways
10.8 FLT4 VEGFA

GO Terms for Hydrocele

Cellular components related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 ICAM1 ITGA3 ITGA4 ITGB1 VEGFA
2 focal adhesion GO:0005925 9.62 ICAM1 ITGA3 ITGA4 ITGB1
3 membrane raft GO:0045121 9.61 ICAM1 ITGB1 SELE
4 receptor complex GO:0043235 9.58 FLT4 ITGA3 ITGB1
5 synaptic membrane GO:0097060 9.37 ITGA3 ITGB1
6 invadopodium membrane GO:0071438 9.16 ITGA3 ITGB1
7 integrin alpha3-beta1 complex GO:0034667 8.96 ITGA3 ITGB1
8 integrin complex GO:0008305 8.8 ITGA3 ITGA4 ITGB1

Biological processes related to Hydrocele according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 CGA FLT4 ITGB1 VEGFA
2 regulation of immune response GO:0050776 9.79 ICAM1 ITGA4 ITGB1
3 cell adhesion GO:0007155 9.77 ICAM1 ITGA3 ITGA4 ITGB1 SELE
4 cell-matrix adhesion GO:0007160 9.63 ITGA3 ITGA4 ITGB1
5 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.61 FLT4 VEGFA
6 integrin-mediated signaling pathway GO:0007229 9.61 ITGA3 ITGA4 ITGB1
7 regulation of Wnt signaling pathway GO:0030111 9.6 ESR1 ITGA3
8 sprouting angiogenesis GO:0002040 9.59 FLT4 VEGFA
9 heterotypic cell-cell adhesion GO:0034113 9.58 ITGA4 ITGB1
10 positive regulation of receptor internalization GO:0002092 9.57 SELE VEGFA
11 cell adhesion mediated by integrin GO:0033627 9.56 ICAM1 ITGB1
12 extracellular matrix organization GO:0030198 9.56 ICAM1 ITGA3 ITGA4 ITGB1
13 cell migration involved in sprouting angiogenesis GO:0002042 9.55 ITGB1 VEGFA
14 negative regulation of Rho protein signal transduction GO:0035024 9.54 ITGA3 ITGB1
15 mammary gland alveolus development GO:0060749 9.52 ESR1 VEGFA
16 vascular endothelial growth factor signaling pathway GO:0038084 9.51 FLT4 VEGFA
17 mesodermal cell differentiation GO:0048333 9.49 ITGA3 ITGB1
18 positive regulation of leukocyte migration GO:0002687 9.48 ITGA4 VEGFA
19 positive regulation of protein kinase C signaling GO:0090037 9.4 FLT4 VEGFA
20 leukocyte migration GO:0050900 9.35 ICAM1 ITGA3 ITGA4 ITGB1 SELE
21 leukocyte tethering or rolling GO:0050901 9.33 ITGA4 ITGB1 SELE
22 response to gonadotropin GO:0034698 9.32 ICAM1 ITGA3
23 leukocyte cell-cell adhesion GO:0007159 8.92 ICAM1 ITGA4 ITGB1 SELE

Molecular functions related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 AFP CGA ESR1 FLT4 ICAM1 ITGA3
2 transmembrane signaling receptor activity GO:0004888 9.58 FLT4 ICAM1 SELE
3 integrin binding GO:0005178 9.43 ICAM1 ITGA3 ITGB1
4 coreceptor activity GO:0015026 9.37 ITGA4 ITGB1
5 laminin binding GO:0043236 9.32 ITGA3 ITGB1
6 C-X3-C chemokine binding GO:0019960 8.96 ITGA4 ITGB1
7 fibronectin binding GO:0001968 8.92 ITGA3 ITGA4 ITGB1 VEGFA

Sources for Hydrocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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