Aliases & Classifications for Hydrocele

MalaCards integrated aliases for Hydrocele:

Name: Hydrocele 12 55 15
Testicular Hydrocele 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9912
ICD10 33 N43.3
UMLS 73 C1720771

Summaries for Hydrocele

MalaCards based summary : Hydrocele, also known as testicular hydrocele, is related to lymphangioma and infected hydrocele, and has symptoms including pain in scrotum An important gene associated with Hydrocele is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Methylene blue and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include testis, prostate and endothelial, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Wikipedia : 76 A hydrocele is an accumulation of serous fluid in a body cavity. A hydrocele testis is the accumulation... more...

Related Diseases for Hydrocele

Diseases related to Hydrocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 28.8 FLT4 VEGFA
2 infected hydrocele 12.2
3 filarial elephantiasis 11.4
4 irons bhan syndrome 10.9
5 lymphedema, hereditary, ia 10.9
6 testicular seminoma 10.9
7 spermatocele 10.6
8 mooren's ulcer 10.6 ITGA4 SELE
9 actinic prurigo 10.5 ITGA4 SELE
10 polyembryoma 10.5 AFP CGA
11 sacrococcygeal teratoma 10.5 AFP CGA
12 mixed germ cell tumor 10.5 AFP CGA
13 triploidy 10.5 AFP CGA
14 inguinal hernia 10.4
15 cervical carcinosarcoma 10.4 ESR1 SELE
16 reproductive organ benign neoplasm 10.3 AFP ESR1
17 orofaciodigital syndrome viii 10.3 AFP CGA
18 pustulosis palmaris et plantaris 10.3 ITGB1 SELE
19 chylothorax, congenital 10.3 FLT4 ITGB1
20 hemangioendothelioma 10.3 FLT4 PECAM1
21 kaposiform hemangioendothelioma 10.3 FLT4 PECAM1
22 filariasis 10.3
23 tubular adenocarcinoma 10.2 AFP ESR1
24 endometritis 10.2 ESR1 SELE
25 epididymitis 10.1
26 vaginitis 10.1
27 rheumatoid vasculitis 10.1 CD44 SELE
28 plague 10.1 PECAM1 SELE
29 breast giant fibroadenoma 10.0 CD44 ESR1
30 ovarian cyst 10.0 AFP VEGFA
31 peritonitis 10.0
32 cryptorchidism, unilateral or bilateral 10.0
33 elephantiasis 10.0
34 critical limb ischemia 10.0 SELE VEGFA
35 hydronephrosis 10.0
36 varicocele 10.0
37 capillary hemangioma 9.9 PECAM1 VEGFA
38 radiation proctitis 9.9 PECAM1 VEGFA
39 testicular torsion 9.9
40 pancreatitis 9.9
41 epithelioid hemangioendothelioma 9.9 PECAM1 VEGFA
42 endophthalmitis 9.9 SELE VEGFA
43 cystadenoma 9.8
44 rhabdomyosarcoma 9.8
45 leukostasis 9.8 SELE VEGFA
46 hemifacial spasm 9.8 FLT4 VEGFA
47 adenomyosis 9.8 ESR1 VEGFA
48 telangiectasis 9.8 AFP VEGFA
49 peliosis hepatis 9.8 AFP ITGA4 VEGFA
50 cystic fibrosis 9.8

Graphical network of the top 20 diseases related to Hydrocele:



Diseases related to Hydrocele

Symptoms & Phenotypes for Hydrocele

UMLS symptoms related to Hydrocele:


pain in scrotum

GenomeRNAi Phenotypes related to Hydrocele according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 AFP CD44 ESR1 FLT4 ITGA4 ITGB1

MGI Mouse Phenotypes related to Hydrocele:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.24 ITGA3 ITGA4 ITGB1 PECAM1 SELE VEGFA
2 homeostasis/metabolism MP:0005376 10.21 AFP CD44 CGA ESR1 FLT4 ITGA3
3 cellular MP:0005384 10.18 CD44 ESR1 ITGA3 ITGA4 ITGB1 PECAM1
4 immune system MP:0005387 10.15 CD44 ESR1 FLT4 ITGA3 ITGA4 ITGB1
5 growth/size/body region MP:0005378 10.14 VEGFA CD44 CGA ESR1 FLT4 ITGA3
6 digestive/alimentary MP:0005381 10.11 PECAM1 VEGFA CD44 ESR1 FLT4 ITGA3
7 endocrine/exocrine gland MP:0005379 10.09 AFP CD44 CGA ESR1 ITGA3 ITGB1
8 hematopoietic system MP:0005397 10.07 CD44 ESR1 ITGA4 ITGB1 PECAM1 SELE
9 mortality/aging MP:0010768 10.06 ITGB1 SELE VEGFA AFP CD44 ESR1
10 embryo MP:0005380 10.03 ESR1 FLT4 ITGA3 ITGA4 ITGB1 VEGFA
11 liver/biliary system MP:0005370 10.03 AFP CD44 ESR1 FLT4 ITGB1 PECAM1
12 integument MP:0010771 10.02 CD44 ESR1 FLT4 ITGA3 ITGB1 SELE
13 limbs/digits/tail MP:0005371 9.85 CD44 ESR1 ITGA3 ITGB1 VEGFA
14 muscle MP:0005369 9.85 CD44 ESR1 FLT4 ITGB1 PECAM1 VEGFA
15 neoplasm MP:0002006 9.8 AFP CD44 ESR1 ITGA3 ITGB1 VEGFA
16 normal MP:0002873 9.73 CD44 ESR1 FLT4 ITGB1 SELE VEGFA
17 renal/urinary system MP:0005367 9.63 PECAM1 VEGFA CD44 ESR1 ITGA3 ITGB1
18 reproductive system MP:0005389 9.5 AFP CD44 CGA ESR1 FLT4 ITGB1
19 respiratory system MP:0005388 9.17 CD44 ESR1 ITGA3 ITGB1 PECAM1 SELE

Drugs & Therapeutics for Hydrocele

Drugs for Hydrocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 2 61-73-4
2
Clonidine Approved Phase 2 4205-90-7 2803
3
Ropivacaine Approved Phase 2,Not Applicable 84057-95-4 71273 175805
4 Analgesics Phase 2,Not Applicable
5 Central Nervous System Depressants Phase 2,Not Applicable
6 Anesthetics Phase 2,Not Applicable
7 Anesthetics, Local Phase 2,Not Applicable
8 Peripheral Nervous System Agents Phase 2,Not Applicable
9 Adrenergic Agents Phase 2
10 Adrenergic Agonists Phase 2
11 Adrenergic alpha-2 Receptor Agonists Phase 2
12 Adrenergic alpha-Agonists Phase 2
13 Sympatholytics Phase 2
14 Neurotransmitter Agents Phase 2
15 Antihypertensive Agents Phase 2
16 Autonomic Agents Phase 2
17
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
18
Levobupivacaine Approved, Investigational Not Applicable 27262-47-1 92253
19
Polidocanol Approved Not Applicable 9002-92-0
20
Albendazole Approved, Vet_approved 54965-21-8 2082
21
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
22
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
23
Ibuprofen Approved Not Applicable 15687-27-1 3672
24 Pharmaceutical Solutions Not Applicable
25 Follicle Stimulating Hormone
26 Narcotics Not Applicable
27 Cyclooxygenase Inhibitors Not Applicable
28 Analgesics, Non-Narcotic Not Applicable
29 Analgesics, Opioid Not Applicable
30 Androgens
31 Hormones
32 Anthelmintics
33 Anti-Infective Agents
34 Antiparasitic Agents
35 Anti-Inflammatory Agents Not Applicable
36 Lipoxygenase Inhibitors
37 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
38 Antirheumatic Agents Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Laparoscopic Inguinal Hernia Repair in Infancy and Childhood Unknown status NCT02239185 Phase 3
2 Dye Assisted Lymphatic Sparing Subinguinal Varicocelectomy Completed NCT01259258 Phase 2
3 The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children Completed NCT00130091 Phase 2 clonidine
4 Lord´s Procedure Versus Sclerotherapy for Testicular Hydrocele; a Randomized Controlled Study Unknown status NCT02082613 Not Applicable
5 Trial of Laparoscopic Compared to Open Inguinal Hernia Repair in Children Younger Than 3 Years Unknown status NCT00716768 Not Applicable
6 Transversus Abdominis Plane Block in Pediatrics: Volume or Concentration ? Unknown status NCT02064088 Not Applicable Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group;Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
7 Assessing the Rates of Major Complications in Combined Mini-incision Microscopic Varicocelectomy Completed NCT02092311 Not Applicable
8 A Comparison of Testicular Volume and Blood Flow in Patients With Inguinal Hernia, Hydrocele, and Cord Cyst Completed NCT03033381 Not Applicable
9 Study of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Surgery Completed NCT01698268 Not Applicable
10 Dominican Republic Mission Cost Analysis Completed NCT01872364
11 The Caudal Space in Children: Ultrasound Evaluation Completed NCT01896076
12 Visual Guidelines and Tutoring in Pediatric Urological Surgery Completed NCT02040389 Not Applicable
13 Outcomes of Intra-Cytoplasmic Sperm Injection in Infertile Men With Non-tense Vaginal Hydrocele Recruiting NCT03532386
14 Does Benign Prostatic Obstruction Cause Hypertension? Recruiting NCT02347436
15 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575
16 Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG Recruiting NCT03268252
17 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
18 Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery Recruiting NCT02603848 Not Applicable Ibuprofen;Morphine
19 The Effect and Prognosis of Different Operations on Varicocele - a Single-center Clinical Study Active, not recruiting NCT01757548 Not Applicable
20 Opioid Use, Storage, and Disposal Among Pediatric Patients After Surgery Enrolling by invitation NCT03575377 Not Applicable
21 Comparing Ilioinguinal Single-shot and Three-layer Blocks Terminated NCT01625780 Not Applicable

Search NIH Clinical Center for Hydrocele

Genetic Tests for Hydrocele

Anatomical Context for Hydrocele

MalaCards organs/tissues related to Hydrocele:

41
Testis, Prostate, Endothelial, Testes, Kidney, Colon, Appendix

Publications for Hydrocele

Articles related to Hydrocele:

(show top 50) (show all 593)
# Title Authors Year
1
Re: MicroRNA miR-371a-3p-A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 29677902 )
2018
2
A case of giant hemorrhagic hydrocele testis. ( 29556473 )
2018
3
Not a Hydrocele! ( 29502879 )
2018
4
Shear wave elastography evaluation of testes with non-communicating hydrocele in infants and toddlers: AA preliminary study. ( 29724465 )
2018
5
Unusual Cause of Acute Scrotal Pain-Inflammatory Noncommunicating Hydrocele: A Pediatric Case Report. ( 29560001 )
2018
6
Malignant hydrocele: a rare manifestation of peritoneal carcinomatosis of colorectal origin as a transcoelomic spread into the scrotum - case report and literature overview. ( 29463171 )
2018
7
Microscopic subinguinal varicocelectomy in 100 consecutive cases: Spermatic cord vascular anatomy, recurrence and hydrocele outcome analysis. ( 29713549 )
2018
8
Pediatric genital lymphedema with recurrent hydrocele and late-onset secondary skin changes. ( 27978613 )
2017
9
Learning Curves for Laparoscopic Repair of Inguinal Hernia and Communicating Hydrocele in Children. ( 29021976 )
2017
10
A Rare Cause of Recurrent Vaginal Hydrocele: Herniating Mesenteric Hydatid Cyst. ( 28979358 )
2017
11
A Rare Case Report of a Paratesticular Fibrous Pseudotumor Mimicking a Hydrocele. ( 29057177 )
2017
12
Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulinA G4-related disease. ( 28809065 )
2017
13
A comparison of preoperative and postoperative testicular volume and blood flow in patients with inguinal hernia, hydrocele, and cord cyst: A prospective cohort study. ( 28523038 )
2017
14
Persistent Mullerian Duct Syndrome Presenting in an Incarcerated Recurrent Inguinal Hernia with Hydrocele. ( 28331809 )
2017
15
Hydrocele with a surprise: Malignant mesothelioma of the tunica vaginalis - Case report and review of literature. ( 28216946 )
2017
16
Hydrocele Caused by Peritoneal Fluid Leakage Through Inguinal Canal. ( 28512168 )
2017
17
A systematic review and meta-analysis concerning single-site laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. ( 28389795 )
2017
18
Migration of a ventriculoperitoneal shunt catheter through the processus vaginalis in infants: how serious inguinal hernia and hydrocele might be. ( 28616670 )
2017
19
Current practice regarding timing of patent processus vaginalis ligation for idiopathic hydrocele in young boys: a survey of UK surgeons. ( 28424863 )
2017
20
Efficacy of the traditional Japanese medicine goreisan for the resolution of spermatic cord hydrocele in children. ( 28710555 )
2017
21
Bilateral hydrocele. Uncommon clinical presentation of primary testicular lymphoma in the elderly. ( 28383626 )
2017
22
Methylene blue dye for identification of processus vaginalis during hydrocele repair: experience in a teaching hospital. ( 28176510 )
2017
23
Hydrocele of the canal of Nuck presenting as a sausage-shaped mass. ( 28978588 )
2017
24
Adolescent Hydrocele Carrying a Surprise: A Case of Papillary Cystadenoma of the Epididymis. ( 29154985 )
2017
25
Management of Abdomino-scrotal hydrocele (ASH)/Scrotal-inguino-retroperitoneal (SIR) hydrocele in a renal transplant patient. ( 29423145 )
2017
26
A comparison between totally laparoscopic hydrocelectomy and scrotal incision hydrocelectomy with laparoscopic high ligation for pediatric cord hydrocele. ( 28493163 )
2017
27
Laparoscopic Treatment of Hydrocele of the Canal of Nuck in Pediatric Patients. ( 29076118 )
2017
28
Editorial Comment to Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulin G4-related disease. ( 28809054 )
2017
29
Exploration Of The Contralateral Groin In Paediatric Inguinal Hernia Or Hydrocele Based On Ultrasound Findings - Is It Justified? ( 28712167 )
2017
30
Abdominoscrotal hydrocele in an infant boy. ( 28551604 )
2017
31
Endometriosis-associated hydrocele of the canal of Nuck with immunohistochemical confirmation: a case report. ( 29262869 )
2017
32
The role of transforming growth factor beta 1 in communicating and non-communicating hydrocele. ( 27146503 )
2016
33
Congenital hernias and hydrocele: Importance of age. ( 27251527 )
2016
34
Novel Surgical Approach to Giant Abdominoscrotal Hydrocele - Video. ( 27614118 )
2016
35
Hydrocele of the Canal of Nuck (Female Hydrocele): A Rare Differential for Inguino-Labial Swelling. ( 27042529 )
2016
36
Mesothelioma of the tunica vaginalis in a patient with giant hydrocele. ( 26929469 )
2016
37
MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. ( 26989896 )
2016
38
Abdominoscrotal hydrocele: A systematic review. ( 27421822 )
2016
39
Hydrocele of the Canal of Nuck in a Female Adult. ( 27689059 )
2016
40
Ectopic Hydrocele After Testicular Transposition. ( 26801808 )
2016
41
Single massive abdominoscrotal hydrocele in adult: should be orchiectomy always performed ? ( 27625319 )
2016
42
Abdominoscrotal Hydrocele. ( 27018108 )
2016
43
The Effect of Resident Involvement on Surgical Outcomes for Common Urologic Procedures: A Case Study of Uni- and Bilateral Hydrocele Repair. ( 27107625 )
2016
44
Ascending testis after repair of pediatric inguinal hernia and hydrocele: A misunderstood operative complication. ( 27727095 )
2016
45
Single-site laparoscopic percutaneous extraperitoneal closure of the internal ring using an epidural and spinal needle: excellent results in 1464 children with inguinal hernia/hydrocele. ( 27815740 )
2016
46
Hydrocele in the Canal of Nuck - CT appearance of a developmental groin anomaly. ( 28580058 )
2016
47
Detection of anti-filarial antibody among hydrocele patients living in an endemic area for filariasis. ( 28217582 )
2016
48
Giant Scrotal Hydrocele and Bilateral Leg Lymphedema as Clinical Manifestation of Chronic Lymphatic Filariasis. ( 27840360 )
2016
49
Current concepts in the management of inguinal hernia and hydrocele in pediatric patients in laparoscopic era. ( 27521714 )
2016
50
Torsion of a Communicating Hydrocele Presented as Acute Scrotum: A Case Report and Literature Review. ( 28003926 )
2016

Variations for Hydrocele

Expression for Hydrocele

Search GEO for disease gene expression data for Hydrocele.

Pathways for Hydrocele

Pathways related to Hydrocele according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 CGA ITGA3 ITGA4 ITGB1 PECAM1 VEGFA
2
Show member pathways
12.88 CD44 ITGA3 ITGA4 ITGB1 PECAM1 SELE
3
Show member pathways
12.78 FLT4 ITGA3 ITGA4 ITGB1
4
Show member pathways
12.76 FLT4 ITGA3 ITGA4 ITGB1 VEGFA
5
Show member pathways
12.69 FLT4 ITGA3 ITGA4 ITGB1 VEGFA
6
Show member pathways
12.67 ESR1 ITGA3 ITGA4 ITGB1
7 12.6 ESR1 FLT4 ITGA3 ITGB1 VEGFA
8
Show member pathways
12.48 ITGA4 ITGB1 PECAM1 VEGFA
9
Show member pathways
12.46 CD44 ITGA3 ITGA4 ITGB1 PECAM1
10
Show member pathways
12.2 CD44 ESR1 SELE VEGFA
11
Show member pathways
12.06 ITGA3 ITGA4 ITGB1
12 12.06 CD44 ESR1 ITGB1 VEGFA
13
Show member pathways
11.96 ITGA3 ITGA4 ITGB1
14 11.95 FLT4 ITGA3 ITGA4 ITGB1
15 11.94 PECAM1 SELE VEGFA
16 11.92 AFP ITGB1 VEGFA
17 11.87 CD44 ITGA4 ITGB1
18 11.78 ITGA4 ITGB1 PECAM1 SELE
19 11.75 CD44 ITGA3 ITGA4
20
Show member pathways
11.73 CD44 ITGA3 ITGA4 ITGB1 PECAM1
21
Show member pathways
11.72 CGA ESR1 VEGFA
22 11.69 FLT4 ITGB1 PECAM1
23 11.66 ITGA3 ITGA4 ITGB1
24 11.64 AFP CGA SELE
25 11.49 ITGA3 ITGA4 ITGB1
26 11.38 ITGA3 ITGA4 ITGB1
27
Show member pathways
11.35 CD44 ITGA3 ITGA4 ITGB1 PECAM1 SELE
28
Show member pathways
11.25 CD44 ITGA4 ITGB1
29 11.22 CD44 ITGB1
30 11.15 ITGA3 ITGB1 PECAM1
31 11.12 ITGA3 ITGB1
32 11.09 ITGA3 ITGB1
33 11 FLT4 ITGB1
34 10.85 CD44 ITGA3 ITGB1 SELE
35
Show member pathways
10.82 FLT4 VEGFA

GO Terms for Hydrocele

Cellular components related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CD44 ITGA3 ITGA4 ITGB1 VEGFA
2 focal adhesion GO:0005925 9.62 CD44 ITGA3 ITGA4 ITGB1
3 membrane raft GO:0045121 9.61 ITGB1 PECAM1 SELE
4 receptor complex GO:0043235 9.54 FLT4 ITGA3 ITGB1
5 synaptic membrane GO:0097060 9.4 ITGA3 ITGB1
6 invadopodium membrane GO:0071438 9.16 ITGA3 ITGB1
7 integrin alpha3-beta1 complex GO:0034667 8.96 ITGA3 ITGB1
8 integrin complex GO:0008305 8.8 ITGA3 ITGA4 ITGB1

Biological processes related to Hydrocele according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.87 CGA FLT4 ITGB1 VEGFA
2 cell adhesion GO:0007155 9.8 CD44 ITGA3 ITGA4 ITGB1 SELE
3 integrin-mediated signaling pathway GO:0007229 9.63 ITGA3 ITGA4 ITGB1
4 cell-matrix adhesion GO:0007160 9.62 CD44 ITGA3 ITGA4 ITGB1
5 regulation of Wnt signaling pathway GO:0030111 9.58 ESR1 ITGA3
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 FLT4 VEGFA
7 positive regulation of receptor internalization GO:0002092 9.56 SELE VEGFA
8 heterotypic cell-cell adhesion GO:0034113 9.55 ITGA4 ITGB1
9 extracellular matrix organization GO:0030198 9.55 CD44 ITGA3 ITGA4 ITGB1 PECAM1
10 negative regulation of Rho protein signal transduction GO:0035024 9.54 ITGA3 ITGB1
11 mammary gland alveolus development GO:0060749 9.52 ESR1 VEGFA
12 cell migration involved in sprouting angiogenesis GO:0002042 9.51 ITGB1 VEGFA
13 positive regulation of leukocyte migration GO:0002687 9.49 ITGA4 VEGFA
14 mesodermal cell differentiation GO:0048333 9.48 ITGA3 ITGB1
15 positive regulation of protein kinase C signaling GO:0090037 9.43 FLT4 VEGFA
16 leukocyte tethering or rolling GO:0050901 9.43 ITGA4 ITGB1 SELE
17 diapedesis GO:0050904 9.37 ITGA4 PECAM1
18 leukocyte cell-cell adhesion GO:0007159 9.26 ITGA4 ITGB1 PECAM1 SELE
19 leukocyte migration GO:0050900 9.1 CD44 ITGA3 ITGA4 ITGB1 PECAM1 SELE

Molecular functions related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.32 ITGA4 ITGB1
2 laminin binding GO:0043236 9.16 ITGA3 ITGB1
3 C-X3-C chemokine binding GO:0019960 8.96 ITGA4 ITGB1
4 fibronectin binding GO:0001968 8.92 ITGA3 ITGA4 ITGB1 VEGFA
5 protein binding GO:0005515 10 AFP CD44 CGA ESR1 FLT4 ITGA3

Sources for Hydrocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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