Aliases & Classifications for Hydrocele

MalaCards integrated aliases for Hydrocele:

Name: Hydrocele 12 54 6 15
Testicular Hydrocele 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9912
ICD10 32 N43.3
UMLS 70 C1720771

Summaries for Hydrocele

MalaCards based summary : Hydrocele, also known as testicular hydrocele, is related to infected hydrocele and spermatocele, and has symptoms including pain in scrotum An important gene associated with Hydrocele is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Pathways in cancer. The drugs Clonidine and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and appendix, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 A hydrocele is an accumulation of serous fluid in a body cavity. A hydrocele testis is the accumulation... more...

Related Diseases for Hydrocele

Diseases related to Hydrocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 infected hydrocele 32.1 CALB2 AFP
2 spermatocele 30.7 CALB2 AFP
3 inguinal hernia 30.2 SELE PECAM1 ITGB1 ITGA4 ITGA3 ICAM1
4 cryptorchidism, unilateral or bilateral 30.2 ESR1 EPPIN CGA AFP
5 mixed germ cell tumor 30.1 CGA AFP
6 lymphangioma 30.1 VEGFA PECAM1 FLT4
7 leiomyosarcoma 29.9 VEGFA PECAM1 ESR1
8 benign mesothelioma 29.9 PECAM1 KRT7 KRT19 CALB2
9 endodermal sinus tumor 29.8 MIR371A KRT7 AFP
10 testicular granulosa cell tumor 29.8 CALB2 AFP
11 cystadenoma 29.7 KRT7 CALB2 AFP
12 tubular adenocarcinoma 29.7 KRT7 ESR1 AFP
13 germ cell cancer 29.7 MIR371A ESR1 CGA AFP
14 testicular fibroma 29.6 CALB2 AFP
15 teratoma 29.6 KRT7 CGA CALB2 AFP
16 cystic lymphangioma 29.5 PECAM1 CALB2 AFP
17 adenomatoid tumor 29.5 KRT7 CALB2 AFP
18 epididymis adenocarcinoma 29.3 KRT7 CALB2 AFP
19 sertoli cell tumor 29.3 KRT7 CALB2 AFP
20 hemangioma 29.1 VEGFA RPL5 PECAM1 KRT7 FLT4 DIPK1A
21 renal cell carcinoma, nonpapillary 28.0 VEGFA PECAM1 KRT7 KRT19 ICAM1 FLT4
22 filarial elephantiasis 11.1
23 lymphatic malformation 1 11.0
24 elephantiasis 11.0
25 testicular seminoma 10.9
26 multiple congenital anomalies-hypotonia-seizures syndrome 10.9
27 infantile spasms broad thumbs 10.9
28 filariasis 10.6
29 prostate angiosarcoma 10.4 VEGFA PECAM1
30 central nervous system hemangioma 10.4 VEGFA PECAM1
31 pediatric angiosarcoma 10.4 VEGFA PECAM1
32 retroperitoneal hemangiopericytoma 10.4 VEGFA PECAM1
33 varicocele 10.4
34 chorioangioma 10.4 PECAM1 AFP
35 childhood endodermal sinus tumor 10.4 MIR371A AFP
36 thymus lipoma 10.4 KRT19 AFP
37 immune system organ benign neoplasm 10.4 KRT19 AFP
38 urethra transitional cell carcinoma 10.4 PECAM1 ICAM1
39 bacillary angiomatosis 10.4 VEGFA PECAM1
40 mixed germ cell cancer 10.4 MIR371A AFP
41 radiation proctitis 10.4 VEGFA PECAM1
42 polyembryoma 10.4 CGA AFP
43 sacrococcygeal teratoma 10.4 CGA AFP
44 paratesticular lipoma 10.3 KRT19 AFP
45 lipoma of spermatic cord 10.3 KRT19 AFP
46 triploidy 10.3 CGA AFP
47 angiokeratoma circumscriptum 10.3 VEGFA PECAM1
48 cervical clear cell adenocarcinoma 10.3 ESR1 AFP
49 glomeruloid hemangioma 10.3 VEGFA PECAM1
50 sclerosing hepatic carcinoma 10.3 KRT19 AFP

Graphical network of the top 20 diseases related to Hydrocele:



Diseases related to Hydrocele

Symptoms & Phenotypes for Hydrocele

UMLS symptoms related to Hydrocele:


pain in scrotum

MGI Mouse Phenotypes related to Hydrocele:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 CD44 ESR1 FLT4 ICAM1 ITGA3 ITGA4
2 homeostasis/metabolism MP:0005376 10.28 AFP CD44 CGA DIPK1A ESR1 FLT4
3 cellular MP:0005384 10.27 CD44 ESR1 ICAM1 ITGA3 ITGA4 ITGB1
4 digestive/alimentary MP:0005381 10.18 CD44 ESR1 FLT4 ICAM1 ITGA3 ITGB1
5 immune system MP:0005387 10.18 CD44 ESR1 FLT4 ICAM1 ITGA3 ITGA4
6 endocrine/exocrine gland MP:0005379 10.16 AFP CD44 CGA ESR1 ICAM1 ITGA3
7 integument MP:0010771 10.02 CD44 ESR1 FLT4 ICAM1 ITGA3 ITGB1
8 liver/biliary system MP:0005370 10.02 AFP CD44 ESR1 FLT4 ITGB1 KRT19
9 neoplasm MP:0002006 9.86 AFP CD44 ESR1 ICAM1 ITGA3 ITGB1
10 normal MP:0002873 9.81 CALB2 CD44 ESR1 FLT4 ITGB1 KRT19
11 renal/urinary system MP:0005367 9.56 CD44 ESR1 ITGA3 ITGB1 KRT7 PECAM1
12 respiratory system MP:0005388 9.28 CD44 ESR1 ITGA3 ITGB1 KRT19 PECAM1

Drugs & Therapeutics for Hydrocele

Drugs for Hydrocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 2 4205-90-7 2803
2
Ropivacaine Approved Phase 2 84057-95-4 71273 175805
3 Adrenergic alpha-Agonists Phase 2
4 Anesthetics Phase 2
5 Neurotransmitter Agents Phase 2
6 Adrenergic Agonists Phase 2
7 Antihypertensive Agents Phase 2
8 Sympatholytics Phase 2
9 Anesthetics, Local Phase 2
10 Analgesics Phase 2
11 Adrenergic Agents Phase 2
12
Polidocanol Approved 9002-92-0
13
Levobupivacaine Approved, Investigational 27262-47-1 92253
14 Pharmaceutical Solutions
15 Sclerosing Solutions
16 Hormones
17 Follicle Stimulating Hormone
18 Androgens

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children Completed NCT00130091 Phase 2 clonidine
2 Lord´s Procedure Versus Sclerotherapy for Testicular Hydrocele; a Randomized Controlled Study. Unknown status NCT02082613
3 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
4 Volume or Concentration for the Transverse Abdominal Plane Block in Children Aged 1-5 Years: Analgesic Effects and Safety Unknown status NCT02064088 Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group;Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
5 The Use of Ligasure (r) for Cutting and Coagulations of Tissues in Hydrocelectomy Surgery Completed NCT04406077
6 Outcomes of Intra-Cytoplasmic Sperm Injection in Infertile Men With Non-tense Vaginal Hydrocele Completed NCT03532386
7 A Comparison of Preoperative and Postoperative Testicular Volume and Blood Flow in Patients With Inguinal Hernia, Hydrocele, and Cord Cyst: A Prospective Cohort Study Completed NCT03033381
8 The Caudal Space in Children: Ultrasound Evaluation Completed NCT01896076
9 Assessing Post-operative Rates of Recurrence, Hydrocele and Testicular Atrophy in Patients Operated With a New Approach of Varicocelectomy Named Combined Mini-incision Microscopic Varicocelectomy (CMMV) Completed NCT02092311
10 The Efficacy of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Completed NCT01698268
11 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
12 Determine the Efficacy of Closed Suction Drain After Hydrocelectomy in Primary Vaginal Hydrocele: An Open-label Randomised Controlled Trial (END Trial) Not yet recruiting NCT04653402
13 Feasibility and Efficacy of Adaptive Closed-loop Brain-computer Interface in Laryngeal Dystonia Not yet recruiting NCT04421365

Search NIH Clinical Center for Hydrocele

Genetic Tests for Hydrocele

Anatomical Context for Hydrocele

MalaCards organs/tissues related to Hydrocele:

40
Testis, Testes, Appendix, Prostate, Endothelial, Smooth Muscle, Colon

Publications for Hydrocele

Articles related to Hydrocele:

(show top 50) (show all 2474)
# Title Authors PMID Year
1
Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations. 61 54
16965327 2006
2
Radiological patterns of incidental epididymitis in mild-to-moderate COVID-19 patients revealed by colour Doppler ultrasound. 61
33565141 2021
3
First report of urinary tract infection caused by Comamonas kerstersii in a goat. 61
33766029 2021
4
Surgical Treatment of Primary Penile Scrotal Lymphedema: A Case Report. 61
32861698 2021
5
Is There Bacterial Growth Inside the Tunica Vaginalis Cavity in Patients With Unsalvageable Testicular Torsion? 61
33278461 2021
6
Testicular torsion in the medicolegal perspective: Why is the diagnosis missing? 61
33630295 2021
7
Testicular leydig cell tumor revealed by hydrocele. 61
33318945 2021
8
Unusual case of a hydrocele. 61
32060032 2021
9
Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model. 61
33547508 2021
10
Differential Diagnosis of Acute Scrotum in Childhood and Adolescence with High-Resolution Duplex Sonography. 61
33530122 2021
11
Risk factors influencing ascending testis after laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. 61
33388952 2021
12
Health beliefs and health seeking behavior towards lymphatic filariasis morbidity management and disability prevention services in Luangwa District, Zambia: Community and provider perspectives. 61
33617551 2021
13
Laparoscopic assisted hydrocelectomy of the canal of Nuck: a case report. 61
33599854 2021
14
Comparison of intra- and extra-corporeal laparoscopic hernia repair in children: A systematic review and pooled data-analysis. 61
33674123 2021
15
Complications after scrotal surgery - still a major issue? 61
33569989 2021
16
Late testicular relapse two decades after primary extragonadal germ cell tumor with uncommon metastases: a case report. 61
33541424 2021
17
The validity of grayscale and color Doppler ultrasound in assessment of scrotal swellings: a retrospective study in a large case series. 61
32336118 2021
18
Exploring determinants of hydrocele surgery coverage related to Lymphatic Filariasis in Nepal: An implementation research study. 61
33635870 2021
19
Establishment of Single-Port, Laparoscopic, Pediatric Hernia Repair in a Developing Country. 61
32990497 2021
20
Surgical management of a large retroperitoneal liposarcoma: A case study. 61
33318934 2021
21
Clinical effect of minimally invasive surgery for inguinal cryptorchidism. 61
33407324 2021
22
Opioid prescribing is excessive and variable after pediatric ambulatory urologic surgery. 61
33514499 2021
23
Side predilection in congenital anomalies of the kidney, urinary and genital tracts. 61
32933872 2020
24
The story of Lymphatic Filariasis elimination as a public health problem from Yemen. 61
32828916 2020
25
[Characteristics of endolymphatic hydrops in low frequency descent sudden hearing loss]. 61
33342144 2020
26
Progress and impact of 20 years of a lymphatic filariasis elimination programme in South-East Asia. 61
33349881 2020
27
Elimination of Lymphatic Filariasis in Shandong Province, China, 1957-2015. 61
32795160 2020
28
Hydroceles of the Canal of Nuck in Adults-Diagnostic, Treatment and Results of a Rare Condition in Females. 61
33322831 2020
29
Robotic-assisted laparoscopic artery-sparing varicocelectomy using indocyanine green fluorescence angiography: Initial experience. 61
32786090 2020
30
Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana. 61
33180780 2020
31
Laparoscopic Abdominoscrortal Hydrocele: A Case Series. 61
32739309 2020
32
Derivation of a complication burden score based on disability-adjusted life years to assess patient burden following surgery: a pilot study. 61
33155974 2020
33
Percutaneous Internal Ring Suturing for the Minimal Invasive Treatment of Pediatric Inguinal Hernia: A 5-Year Single Surgeon Experience. 61
33234851 2020
34
Diagnostic clues, pitfalls, and imaging characteristics of '-celes' that arise in abdominal and pelvic structures. 61
32356005 2020
35
'Testis-epididymis dissociation' in cryptorchidism and hydrocele: the tip of the iceberg of a persistent genital mesentery. 61
32144436 2020
36
Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019: A Single-Center-Based Study in Wuhan, China. 61
33174632 2020
37
Scrotal Migration of Two Ventriculoperitoneal Shunts Presenting as Hydrocele. 61
33487951 2020
38
Trends in treatment outcomes of hydrocele in Japanese children: A single-institute experience. 61
32748516 2020
39
Editorial Comment to Trends in treatment outcomes of hydrocele in Japanese children: A single-institute experience. 61
33463800 2020
40
A rare case of vulvar superficial myofibroblastoma associated with ambigous and unusual differential diagnosis. 61
32953964 2020
41
Comparison of low-power magnification one-layer vasovasostomy with stent and microscopic two-layer vasovasostomy for vasectomy reversal. 61
31787759 2020
42
The Spectrum of Testicular Pathologies Upon Scrotal Exploration for Acute Scrotum: A Retrospective Analysis. 61
33209540 2020
43
The application of single-port laparoscopic percutaneous internal ring suture for the management of indirect inguinal hernia in female adults. 61
33004858 2020
44
Role of ultrasonographic inferior venacaval assessment in averting spinal anaesthesia-induced hypotension for hernia and hydrocele surgeries-A prospective randomised controlled study. 61
33437072 2020
45
Inguinal Hernias: Diagnosis and Management. 61
33064426 2020
46
Aggressive Angiomyxoma in an 11-Year-Old Boy - Diagnostic and Therapeutic Dilemmas: An Unusual Case Report and Review of the Literature. 61
32479833 2020
47
An Emoji for a Tunica Vaginalis Hydrocele. 61
31870200 2020
48
Implementation of a contextually appropriate pediatric emergency surgical care course in Uganda. 61
33183745 2020
49
Near-Infrared fluorescence imaging using indocyanine green (ICG): Emerging applications in pediatric urology. 61
32747308 2020
50
Analysis of internal spermatic vein embolization through catheter versus laparoscopic high ligation in treatment of left varicocele. 61
32390559 2020

Variations for Hydrocele

ClinVar genetic disease variations for Hydrocele:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PKD2 NM_000297.4(PKD2):c.2241-14C>T SNV Uncertain significance 523353 rs763507546 GRCh37: 4:88986900-88986900
GRCh38: 4:88065748-88065748

Expression for Hydrocele

Search GEO for disease gene expression data for Hydrocele.

Pathways for Hydrocele

Pathways related to Hydrocele according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 VEGFA SELE PECAM1 ITGB1 ITGA4 ITGA3
2 12.72 VEGFA ITGB1 ITGA3 FLT4 ESR1
3
Show member pathways
12.53 VEGFA PECAM1 ITGB1 ITGA4 ICAM1
4
Show member pathways
12.5 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
5
Show member pathways
12.19 VEGFA SELE ICAM1 ESR1 CD44
6 12.18 VEGFA ITGB1 ESR1 CD44
7 11.92 VEGFA SELE PECAM1 ICAM1
8 11.88 VEGFA KRT19 ITGB1 AFP
9 11.83 SELE PECAM1 ITGB1 ITGA4 ICAM1
10 11.82 ITGB1 ITGA4 ICAM1 CD44
11
Show member pathways
11.76 VEGFA ESR1 CGA
12 11.73 PECAM1 ITGB1 FLT4
13 11.7 ITGB1 ITGA4 ITGA3
14
Show member pathways
11.68 SELE PECAM1 ITGB1 ITGA4 ITGA3 CD44
15 11.57 ITGB1 ITGA4 ICAM1
16 11.54 SELE ICAM1 CGA AFP
17
Show member pathways
11.53 VEGFA SELE ICAM1
18 11.41 SELE PECAM1 ICAM1
19
Show member pathways
11.34 ITGB1 ITGA4 CD44
20 11.33 ITGB1 ITGA4 ICAM1
21
Show member pathways
11.29 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
22 11.27 PECAM1 ITGB1 ITGA3
23 11.05 SELE ITGB1 ITGA3 CD44

GO Terms for Hydrocele

Cellular components related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.02 RPL5 PKD2 PECAM1 KRT7 KRT19 ITGB1
2 membrane raft GO:0045121 9.73 SELE PECAM1 ITGB1 ICAM1
3 integrin complex GO:0008305 9.43 ITGB1 ITGA4 ITGA3
4 focal adhesion GO:0005925 9.43 RPL5 ITGB1 ITGA4 ITGA3 ICAM1 CD44
5 invadopodium membrane GO:0071438 9.4 ITGB1 ITGA3
6 integrin alpha4-beta1 complex GO:0034668 9.37 ITGB1 ITGA4
7 cell surface GO:0009986 9.17 VEGFA ITGB1 ITGA4 ITGA3 ICAM1 EPPIN
8 integrin alpha3-beta1 complex GO:0034667 9.16 ITGB1 ITGA3

Biological processes related to Hydrocele according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.84 VEGFA PECAM1 ITGB1 CGA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 VEGFA ICAM1 FLT4 CD44
3 cell adhesion GO:0007155 9.8 SELE PECAM1 ITGB1 ITGA4 ITGA3 ICAM1
4 cell-matrix adhesion GO:0007160 9.71 ITGB1 ITGA4 ITGA3 CD44
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 VEGFA PECAM1 ICAM1 CD44
6 extracellular matrix organization GO:0030198 9.63 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
7 mesodermal cell differentiation GO:0048333 9.56 ITGB1 ITGA3
8 positive regulation of leukocyte migration GO:0002687 9.55 VEGFA ITGA4
9 positive regulation of protein kinase C signaling GO:0090037 9.52 VEGFA FLT4
10 leukocyte tethering or rolling GO:0050901 9.5 SELE ITGB1 ITGA4
11 leukocyte migration GO:0050900 9.5 SELE PECAM1 ITGB1 ITGA4 ITGA3 ICAM1
12 positive regulation of leukocyte tethering or rolling GO:1903238 9.49 SELE ITGA4
13 response to gonadotropin GO:0034698 9.48 ITGA3 ICAM1
14 cell-cell adhesion mediated by integrin GO:0033631 9.46 ITGB1 ITGA4
15 diapedesis GO:0050904 9.43 PECAM1 ITGA4
16 leukocyte cell-cell adhesion GO:0007159 9.02 SELE PECAM1 ITGB1 ITGA4 ICAM1

Molecular functions related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.56 SELE PECAM1 ICAM1 CD44
2 integrin binding GO:0005178 9.26 ITGB1 ITGA4 ITGA3 ICAM1
3 C-X3-C chemokine binding GO:0019960 9.16 ITGB1 ITGA4
4 fibronectin binding GO:0001968 8.92 VEGFA ITGB1 ITGA4 ITGA3

Sources for Hydrocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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