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MCID: HYD005
MIFTS: 46

Hydrocele

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hydrocele

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MalaCards integrated aliases for Hydrocele:

Name: Hydrocele 12 54 15
Testicular Hydrocele 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9912
ICD10 32 N43.3
UMLS 71 C1720771
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Summaries for Hydrocele

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MalaCards based summary : Hydrocele, also known as testicular hydrocele, is related to infected hydrocele and testicular seminoma, and has symptoms including pain in scrotum An important gene associated with Hydrocele is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Ropivacaine and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and kidney, and related phenotypes are cardiovascular system and cellular

Wikipedia : 74 A hydrocele is an accumulation of serous fluid in a body cavity. A hydrocele testis is the accumulation... more...

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Related Diseases for Hydrocele

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Diseases related to Hydrocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 infected hydrocele 33.9 CALB2 AFP
2 testicular seminoma 33.0 CGA AFP
3 inguinal hernia 30.7 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
4 benign mesothelioma 30.4 PECAM1 CALB2 AFP
5 mixed germ cell tumor 30.4 CGA AFP
6 cryptorchidism, unilateral or bilateral 30.4 ESR1 EPPIN CGA AFP
7 lymphangioma 30.2 VEGFA PECAM1 FLT4
8 intussusception 30.2 VEGFA PECAM1 FLT4
9 leiomyosarcoma 30.1 VEGFA PECAM1 ESR1
10 varicose veins 30.0 VEGFA ICAM1 ESR1
11 testicular granulosa cell tumor 29.9 CALB2 AFP
12 germ cell cancer 29.8 MIR371A ESR1 CGA AFP
13 hemangioma 29.8 VEGFA RPL5 PECAM1 FLT4
14 testicular fibroma 29.7 CALB2 AFP
15 teratoma 29.7 ESR1 CGA CALB2 AFP
16 cystic lymphangioma 29.6 PECAM1 CALB2 AFP
17 fibroma 29.6 PECAM1 KRT19 CALB2
18 endometriosis 29.2 VEGFA ESR1 CGA CALB2
19 gastric adenocarcinoma 29.1 VEGFA FLT4 ESR1 CD44 AFP
20 pancreatic adenocarcinoma 28.5 VEGFA KRT19 GRB2 FLT4 ESR1 CD44
21 renal cell carcinoma, nonpapillary 27.7 VEGFA PECAM1 KRT19 ITGB1 ICAM1 FLT4
22 filarial elephantiasis 11.8
23 irons bhan syndrome 11.6
24 elephantiasis 11.6
25 lymphatic malformation 1 11.4
26 multiple congenital anomalies-hypotonia-seizures syndrome 11.2
27 infantile spasms broad thumbs 11.2
28 spermatocele 11.0
29 filariasis 10.7
30 diamond-blackfan anemia 6 10.5 RPL5 DIPK1A
31 diamond-blackfan anemia 1 10.5 RPL5 DIPK1A
32 prostate angiosarcoma 10.5 VEGFA PECAM1
33 central nervous system hemangioma 10.5 VEGFA PECAM1
34 varicocele 10.5
35 childhood endodermal sinus tumor 10.5 MIR371A AFP
36 colonic lymphangioma 10.5 PECAM1 AFP
37 mixed germ cell cancer 10.5 MIR371A AFP
38 intrahepatic bile duct adenoma 10.5 KRT19 AFP
39 pediatric angiosarcoma 10.5 VEGFA PECAM1
40 renal pelvis adenocarcinoma 10.5 KRT19 AFP
41 polyembryoma 10.5 CGA AFP
42 middle ear adenocarcinoma 10.5 PECAM1 AFP
43 retroperitoneal hemangiopericytoma 10.5 VEGFA PECAM1
44 sacrococcygeal teratoma 10.5 CGA AFP
45 urethra transitional cell carcinoma 10.5 PECAM1 ICAM1
46 radiation proctitis 10.4 VEGFA PECAM1
47 triploidy 10.4 CGA AFP
48 glomeruloid hemangioma 10.4 VEGFA PECAM1
49 skin hemangioma 10.4 RPL5 PECAM1 DIPK1A
50 paratesticular lipoma 10.4 KRT19 AFP

Graphical network of the top 20 diseases related to Hydrocele:



Diseases related to Hydrocele
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Symptoms & Phenotypes for Hydrocele

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UMLS symptoms related to Hydrocele:


pain in scrotum

MGI Mouse Phenotypes related to Hydrocele:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 CD44 ESR1 FLT4 GRB2 ICAM1 ITGA3
2 cellular MP:0005384 10.3 CD44 CNTD1 ESR1 GRB2 ICAM1 ITGA3
3 homeostasis/metabolism MP:0005376 10.27 AFP CD44 CGA DIPK1A ESR1 FLT4
4 endocrine/exocrine gland MP:0005379 10.26 AFP CD44 CGA CNTD1 ESR1 GRB2
5 digestive/alimentary MP:0005381 10.25 CD44 ESR1 FLT4 GRB2 ICAM1 ITGA3
6 immune system MP:0005387 10.21 CD44 ESR1 FLT4 GRB2 ICAM1 ITGA3
7 mortality/aging MP:0010768 10.18 AFP CD44 ESR1 FLT4 GRB2 ICAM1
8 embryo MP:0005380 10.15 ESR1 FLT4 GRB2 ITGA3 ITGA4 ITGB1
9 liver/biliary system MP:0005370 10.06 AFP CD44 ESR1 FLT4 ITGB1 KRT19
10 neoplasm MP:0002006 9.97 AFP CD44 ESR1 GRB2 ICAM1 ITGA3
11 normal MP:0002873 9.91 CALB2 CD44 ESR1 FLT4 GRB2 ITGB1
12 renal/urinary system MP:0005367 9.76 CD44 ESR1 GRB2 ITGA3 ITGB1 PECAM1
13 reproductive system MP:0005389 9.65 AFP CD44 CGA CNTD1 ESR1 FLT4
14 respiratory system MP:0005388 9.23 CD44 ESR1 ITGA3 ITGB1 KRT19 PECAM1
Sources

Drugs & Therapeutics for Hydrocele

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Drugs for Hydrocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
4 Anesthetics, Local Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Adrenergic Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Adrenergic Agonists Phase 4
9 Hypnotics and Sedatives Phase 4
10
Clonidine Approved Phase 2 4205-90-7 2803
11
Methylene blue Approved, Investigational Phase 2 61-73-4
12 Antihypertensive Agents Phase 2
13 Sympatholytics Phase 2
14
Polidocanol Approved 9002-92-0
15
Levobupivacaine Approved, Investigational 27262-47-1 92253
16
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
17
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
18
Sevoflurane Approved, Vet_approved 28523-86-6 5206
19
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
20
Albendazole Approved, Vet_approved 54965-21-8 2082
21
Ibuprofen Approved 15687-27-1 3672
22
Morphine Approved, Investigational 57-27-2 5288826
23
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
24 Sclerosing Solutions
25 Pharmaceutical Solutions
26 Follicle Stimulating Hormone
27 Androgens
28 Hormones
29 Anesthetics
30 Antiemetics
31 Analgesics
32 Narcotics
33 Analgesics, Non-Narcotic
34 Analgesics, Opioid
35 Cyclooxygenase Inhibitors
36 Antirheumatic Agents
37 Anti-Inflammatory Agents
38 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Remifentanil-dexmedetomidine Anesthesia as an Alternative Anesthetic for Elective Pediatric Surgery: a Pilot Study. Unknown status NCT02799589 Phase 4 Remifentanil;Dexmedetomidine;Ropivacaine
2 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
3 The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children Completed NCT00130091 Phase 2 clonidine
4 Dye Assisted Lymphatic Sparing Varicocelectomy,Prospective Randomized Study Completed NCT01259258 Phase 2
5 Lord´s Procedure Versus Sclerotherapy for Testicular Hydrocele; a Randomized Controlled Study. Unknown status NCT02082613
6 Volume or Concentration for the Transverse Abdominal Plane Block in Children Aged 1-5 Years: Analgesic Effects and Safety Unknown status NCT02064088 Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group;Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
7 Quality of Life Among Testicular Cancer Survivors Unknown status NCT02304575
8 Comparison Between Laparoscopic Doppler Ultrasound Assisted Laparoscopic Varicocelectomy and Microscopic Subinguinal Varicocelectomy Unknown status NCT02695199
9 The Use of Ligasure (r) for Cutting and Coagulations of Tissues in Hydrocelectomy Surgery Completed NCT04406077
10 Outcomes of Intra-Cytoplasmic Sperm Injection in Infertile Men With Non-tense Vaginal Hydrocele Completed NCT03532386
11 Assessing Post-operative Rates of Recurrence, Hydrocele and Testicular Atrophy in Patients Operated With a New Approach of Varicocelectomy Named Combined Mini-incision Microscopic Varicocelectomy (CMMV) Completed NCT02092311
12 The Efficacy of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Completed NCT01698268
13 The Caudal Space in Children: Ultrasound Evaluation Completed NCT01896076
14 The Effect of Intraoperative Body Temperature on Postoperative Nausea and Vomiting in Pediatric Patients Completed NCT04155931
15 Quadratus Lumborum Block Versus Caudal Block Completed NCT03294291
16 A Comparison of Preoperative and Postoperative Testicular Volume and Blood Flow in Patients With Inguinal Hernia, Hydrocele, and Cord Cyst: A Prospective Cohort Study Completed NCT03033381
17 Laparoscopic Management of Recurrent Inguinal Hernia in Children Completed NCT04266561
18 Unacylated Ghrelin and Obestatin as Promising Biomarkers of Protein Energy Wasting in Children With Chronic Kidney Disease: a Cross-sectional Case-control Study Completed NCT03171116
19 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis: Monitoring Efficacy of Ongoing Treatment Programs in Papua New Guinea Completed NCT03268252
20 Transversus Abdominis Plane Versus Quadratus Lumborum Block for Pediatrics Completed NCT02715999
21 Laparoscopic Inguinal Hernia Repair in Infancy and Childhood; a Prospective Controlled Randomized Study of Two Different Technique Completed NCT02239185
22 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Completed NCT01812109
23 Natural History of Infants With Patent Processus Vaginalis Recruiting NCT03042858
24 Prevalence Survey for Innovative and Intensified Disease Management (IDM) Neglected Tropical Diseases (NTDs): A Cluster Randomised Two-stage Active Case Search for IDM-NTDs in Liberia Recruiting NCT03683745
25 Assessing the Effectiveness of Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery (AIMS) Recruiting NCT02603848 Ibuprofen;Morphine
26 Needlescopic Inversion and Snaring Versus Needlescopic Inversion and Ligation of Hernia Sac for Inguinal Hernia Repair in Girls Recruiting NCT04372212
27 Value of MRI CSF Flowmetry in Assessment of Grey Zone Hydrocephalic Patients Not yet recruiting NCT04060810
28 A New Approach to Ilio-inguinal Nerve Blocks: 3-layer Injection vs Conventional Ultrasound-guided Single-shot Approach Terminated NCT01625780
29 A Prospective, Multi-Centre, Randomized Controlled Study Comparing Varicocelectomy to Observation in Infertile Men With Clinical Varicoceles Terminated NCT00961558

Search NIH Clinical Center for Hydrocele

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Genetic Tests for Hydrocele

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Anatomical Context for Hydrocele

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MalaCards organs/tissues related to Hydrocele:

40
Testis, Testes, Kidney, Appendix, Prostate, Endothelial, Smooth Muscle
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Publications for Hydrocele

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Articles related to Hydrocele:

(show top 50) (show all 2402)
# Title Authors PMID Year
1
Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations. 54 61
16965327 2006
2
Abdominoscrotal hydrocele: A case report. 61
32489888 2020
3
Tension hydrocele as an additional cause of acute scrotum: case series and literature review. 61
30929051 2020
4
Persistent hydrocele fluid in a patient with transitional cell carinoma. 61
32573841 2020
5
Cyst of the Canal of Nuck in adult females: A case report and systematic review. 61
32346477 2020
6
General Anesthesia Maintained with Sevoflurane versus Propofol in Pediatric Surgery Shorter Than 1 Hour: A Randomized Single-Blind Study. 61
32572017 2020
7
Nearly Complete Genome Sequence of Brugia malayi Strain FR3. 61
32527783 2020
8
Complex management of hydrocephalus secondary to choroid plexus hyperplasia. 61
32497849 2020
9
Aggressive angiomyxoma in an 11-year-old boy - diagnostic and therapeutic dilemmas: an unusual case report and review of the literature. 61
32479833 2020
10
Incidental Testicular Pathologies in Patients With Idiopathic Hydrocele Testis: Is Preoperative Scrotal Ultrasound Justified? 61
32366435 2020
11
Analysis of internal spermatic vein embolization through catheter versus laparoscopic high ligation in treatment of left varicocele. 61
32390559 2020
12
Hydrocele in recurrent acute pancreatitis caused by testicular venous obstruction: A case report of a rare complication (CARE-compliant). 61
32358347 2020
13
Upper Gastrointestinal Bleeding Due to a Duodenal Metastasis from Primary Testicular Squamous Cell Carcinoma. 61
32392185 2020
14
Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania. 61
32455556 2020
15
Challenges in the diagnosis of testicular infarction in the presence of prolonged epididymitis: Three cases report and literature review. 61
32474478 2020
16
[Mesothelial proliferation of the tunica vaginalis testis]. 61
32472158 2020
17
Individualized treatment of pediatric inguinal hernia reduces adolescent recurrence rate: an analysis of 3006 cases. 61
31858238 2020
18
Laparoscopic Injection of Tissue Adhesives for Inguinal Hernia Repair in a Rabbit Model: Results of an Experimental Comparative Study with the Standard Laparoscopic Inguinal Hernia Repair. 61
32384247 2020
19
Laparoscopic Repair of Paediatric Indirect Inguinal Hernia: Modified Flip Flap Technique. 61
32523906 2020
20
Incidence of Cord Hydrocele After Laparoscopic Intracorporeal Inguinal Hernia Repair in Male Pediatric Patients: A Comparative Study Between Removing and Leaving the Hernial Sac. 61
32208056 2020
21
Primary rhabdomyosarcoma of tunica vaginalis misdiagnosing as hydrocele: A case report and literature review. 61
31965584 2020
22
Be cautious of "complex hydrocele" on ultrasound in young men. 61
32255327 2020
23
Methylene blue dye for identification of processus vaginalis during hydrocele repair: experience in a teaching hospital. 61
28176510 2020
24
New insights into the expression of androgen and estrogen receptors of the appendix testis in congenital cryptorchidism. 61
32109207 2020
25
Diagnostic clues, pitfalls, and imaging characteristics of '-celes' that arise in abdominal and pelvic structures. 61
32356005 2020
26
Jaboulay's technique contrasted with a novel hydrocelectomy technique using a vessel sealer in the treatment of adult hydrocele: a prospective randomized study. 61
31776880 2020
27
Transscrotal transverse incision for the treatment of middle and low cryptorchidism in children: experience from 796 cases. 61
32183767 2020
28
'Testis-epididymis dissociation' in cryptorchidism and hydrocele: the tip of the iceberg of a persistent genital mesentery. 61
32144436 2020
29
Laparoscopic orchiopexy of palpable undescended testes_ experience of a single tertiary institution with over 773 cases. 61
32178653 2020
30
Economic benefits and costs of surgery for filarial hydrocele in Malawi. 61
32210436 2020
31
Preoperative progressive pneumoperitoneum: The answer for treating giant inguinal hernias while avoiding morbidities? 61
32157504 2020
32
Unusual case of a hydrocele. 61
32060032 2020
33
Case - Tension hydrocele: A rare cause of acute scrotal pain. 61
32017692 2020
34
A Study On Serological Reactivity Profile Of Different Antigen Preparations With Bancroftian Filariasis Human Infection Sera. 61
32096736 2020
35
Mucopolysaccharidosis type VI: case report with first neonatal presentation with ascites fetalis and rapidly progressive cardiac manifestation. 61
32075597 2020
36
Single-incision approach for bilateral inguinal hernia repair in children: A retrospective study. 61
32118783 2020
37
[Effect of tympanoplasty on wet ear with different mucosal status of tympanic cavity]. 61
32086911 2020
38
Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature. 61
32106829 2020
39
Eggshell calcification in a case of longstanding hydrocele. 61
31911411 2020
40
Use of a Novel Open Posterior Wall Technique for Laparoscopic Excision of Hydrocele of the Canal of Nuck in an Adult Female: Case Report. 61
31204382 2020
41
Infertility secondary to an infected hydrocele: A case report. 61
31886135 2020
42
Abdominoscrotal Lymphangioma Masquerading as a Communicating Hydrocele: A Case Report. 61
32342921 2020
43
Office-based, Minimal-Incision Modified Fenestration Technique for Symptomatic Hydroceles Under Local Anesthesia. 61
31626858 2020
44
Comparison Between Processus Vaginalis Sac Tightening Technique and the Conventional Technique in Orchiopexy Surgery Over 10 Years. 61
32257969 2020
45
Testicular schistosomiasis mimicking hydrocele in a child: a case report. 61
32537060 2020
46
Our Laparoscopic Surgical Technique and Experience in Treating Pediatric Inguinal Hernia Over the Past Decade. 61
31896896 2020
47
Urologic Conditions in Infants and Children: Inguinal Hernia, Hydrocele, and Cryptorchidism. 61
31894951 2020
48
An Insight into the Discovery of Potent Antifilarial Leads Against Lymphatic Filariasis. 61
31800381 2020
49
Laparoscopic hydrocelectomy of the canal of Nuck in adult female: Case report and literature review. 61
31918159 2020
50
Pre-operative skin antisepsis with chlorhexidine gluconate baths and wipes does not prevent postoperative surgical site infection in outpatient pediatric urologic inguinal and scrotal surgery. 61
31564588 2019
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Variations for Hydrocele

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Expression for Hydrocele

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Search GEO for disease gene expression data for Hydrocele.
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Pathways for Hydrocele

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Pathways related to Hydrocele according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 63
Show member pathways
 13.33 VEGFA PECAM1 ITGB1 ITGA4 ITGA3 ICAM1
2
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.23 VEGFA PECAM1 ITGB1 ITGA4 ITGA3 GRB2
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.92 VEGFA ITGB1 ITGA4 ITGA3 GRB2 FLT4
4
MAPK Erk Pathway 66
Show member pathways
 12.81 ITGB1 ITGA4 ITGA3 GRB2 ESR1
5
Focal Adhesion 36 1
Show member pathways
 12.74 VEGFA ITGB1 ITGA4 ITGA3 GRB2 FLT4
6
Pathways in cancer 36
12.64 VEGFA ITGB1 ITGA3 GRB2 FLT4 ESR1
7
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling 64
Show member pathways
 12.58 VEGFA PECAM1 ITGB1 ITGA4 ICAM1
8
Degradation of the extracellular matrix 65
Show member pathways
 12.5 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
9
Prolactin Signaling Pathway 36 1
Show member pathways
 12.4 ITGB1 GRB2 ESR1 CGA
10
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.31 ITGB1 ITGA4 ITGA3 GRB2 FLT4
11
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.19 VEGFA ICAM1 GRB2 ESR1 CD44
12
MAPK Signaling: Mitogens 64
Show member pathways
 12.11 ITGB1 ITGA4 ITGA3 GRB2 FLT4
13
Cell adhesion molecules (CAMs) 36
12.02 PECAM1 ITGB1 ITGA4 ICAM1
14
Proteoglycans in cancer 36
11.97 VEGFA ITGB1 GRB2 ESR1 CD44
15
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
11.9 VEGFA KRT19 ITGB1 AFP
16
Adhesion 4
11.85 ITGB1 ITGA4 ICAM1 CD44
17
Hematopoietic cell lineage 36
11.83 ITGA4 ITGA3 CD44
18
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 65
Show member pathways
 11.79 VEGFA ESR1 CGA
19
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.78 VEGFA GRB2 FLT4
20
Angiogenesis (CST) 4
11.76 PECAM1 ITGB1 FLT4
21
Phagocytosis of Microbes 63
11.73 ITGB1 ITGA4 ITGA3
22
Glucocorticoid receptor regulatory network 1
11.71 ICAM1 CGA AFP
23
Cell surface interactions at the vascular wall 65
Show member pathways
 11.68 PECAM1 ITGB1 ITGA4 ITGA3 GRB2 CD44
24
Hepatitis C and Hepatocellular Carcinoma 1
11.48 VEGFA GRB2 CD44
25
Paxillin-dependent events mediated by a4b1 1
Show member pathways
 11.4 ITGB1 ITGA4 CD44
26
Vemurafenib Pathway, Pharmacodynamics 60
11.38 VEGFA GRB2 FLT4
27
Signaling events mediated by TCPTP 1
Show member pathways
 11.36 VEGFA ITGB1 GRB2
28
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms 22
11.31 PECAM1 ITGB1 ITGA3
29
ECM-receptor interaction 36
Show member pathways
 11.29 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
30
Cell adhesion_Cell-matrix glycoconjugates 22
11.28 ITGB1 ITGA3 CD44
31
Immune response_Role of integrins in NK cells cytotoxicity 22
11.1 ITGB1 ITGA4 ICAM1 GRB2
32
VEGFR3 signaling in lymphatic endothelium 1
10.86 ITGB1 GRB2 FLT4
Sources

GO Terms for Hydrocele

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Cellular components related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.02 RPL5 PKD2 PECAM1 KRT19 ITGB1 ITGA4
2 protein-containing complex GO:0032991 9.7 RPL5 PECAM1 ITGB1 ITGA4 GRB2 ESR1
3 cell periphery GO:0071944 9.65 PECAM1 KRT19 ITGA3
4 synaptic membrane GO:0097060 9.61 ITGB1 ITGA3 CALB2
5 integrin complex GO:0008305 9.54 ITGB1 ITGA4 ITGA3
6 invadopodium membrane GO:0071438 9.46 ITGB1 ITGA3
7 focal adhesion GO:0005925 9.43 RPL5 ITGB1 ITGA4 ITGA3 ICAM1 CD44
8 integrin alpha4-beta1 complex GO:0034668 9.4 ITGB1 ITGA4
9 integrin alpha3-beta1 complex GO:0034667 9.26 ITGB1 ITGA3
10 cell surface GO:0009986 9.17 VEGFA ITGB1 ITGA4 ITGA3 ICAM1 EPPIN

Biological processes related to Hydrocele according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
2 positive regulation of cell migration GO:0030335 9.8 VEGFA PECAM1 ITGB1 CGA
3 integrin-mediated signaling pathway GO:0007229 9.71 ITGB1 ITGA4 ITGA3
4 extracellular matrix organization GO:0030198 9.63 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 CD44
5 cell-matrix adhesion GO:0007160 9.62 ITGB1 ITGA4 ITGA3 CD44
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 VEGFA PECAM1 ICAM1 CD44
7 mesodermal cell differentiation GO:0048333 9.52 ITGB1 ITGA3
8 positive regulation of leukocyte migration GO:0002687 9.51 VEGFA ITGA4
9 positive regulation of protein kinase C signaling GO:0090037 9.48 VEGFA FLT4
10 response to gonadotropin GO:0034698 9.46 ITGA3 ICAM1
11 cell-cell adhesion mediated by integrin GO:0033631 9.43 ITGB1 ITGA4
12 diapedesis GO:0050904 9.37 PECAM1 ITGA4
13 leukocyte cell-cell adhesion GO:0007159 9.26 PECAM1 ITGB1 ITGA4 ICAM1
14 leukocyte migration GO:0050900 9.17 PECAM1 ITGB1 ITGA4 ITGA3 ICAM1 GRB2

Molecular functions related to Hydrocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.65 KRT19 ITGB1 ITGA3 ICAM1 GRB2
2 integrin binding GO:0005178 9.26 ITGB1 ITGA4 ITGA3 ICAM1
3 C-X3-C chemokine binding GO:0019960 9.16 ITGB1 ITGA4
4 fibronectin binding GO:0001968 8.92 VEGFA ITGB1 ITGA4 ITGA3
Sources

Sources for Hydrocele

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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