Aliases & Classifications for Hydromyelia

MalaCards integrated aliases for Hydromyelia:

Name: Hydromyelia 54
Hydrorhachis 73

Classifications:



External Ids:

ICD10 33 Q06.4
UMLS 73 C0152444

Summaries for Hydromyelia

NINDS : 54 Hydromyelia refers to an abnormal widening of the central canal of the spinal cord that creates a cavity in which cerebrospinal fluid (commonly known as spinal fluid) can accumulate.  As spinal fluid builds up, it may put abnormal pressure on the spinal cord and damage nerve cells and their connections.  Hydromyelia is sometimes used interchangeably with syringomyelia, the name for a condition that also involves cavitation in the spinal cord.  In hydromyelia, the cavity that forms is connected to the fourth ventricle in the brain, and is almost always associated in infants and children with hydrocephalus or birth defects such as Chiari Malformation II and Dandy-Walker syndrome.  Syringomyelia, however, features a closed cavity and occurs primarily in adults, the majority of whom have Chiari Malformation type 1 or have experienced spinal cord trauma.   Symptoms, which may occur over time, include weakness of the hands and arms, stiffness in the legs; and sensory loss in the neck and arms. Some individuals have severe pain in the neck and arms. Diagnosis is made by magnetic resonance imaging (MRI), which reveals abnormalities in the anatomy of the spinal cord..   

MalaCards based summary : Hydromyelia, also known as hydrorhachis, is related to syringohydromyelia and cowden syndrome 1. An important gene associated with Hydromyelia is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are MicroRNAs in cancer and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hydromyelia

Diseases related to Hydromyelia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 syringohydromyelia 11.2
2 cowden syndrome 1 10.9
3 syringomyelia 10.2
4 hydrocephalus 10.2
5 chiari malformation 10.1
6 type i 10.0
7 familial syringomyelia 9.9
8 primary syringomyelia 9.9
9 chiari malformation type ii 9.9
10 scoliosis 9.9
11 tethered spinal cord syndrome 9.9
12 bednar tumor 9.9 S100B VIM
13 primary hepatic neuroendocrine carcinoma 9.9 S100B VIM
14 ossifying fibromyxoid tumor 9.9 S100B VIM
15 fibrous meningioma 9.9 S100B VIM
16 chordoid meningioma 9.8 S100B VIM
17 syringocystadenoma papilliferum 9.8 S100B VIM
18 eccrine porocarcinoma 9.8 S100B VIM
19 myxopapillary ependymoma 9.8 S100B VIM
20 monophasic synovial sarcoma 9.8 S100B VIM
21 spiradenoma 9.8 S100B VIM
22 melanotic neuroectodermal tumor 9.8 S100B VIM
23 syringoma 9.8 S100B VIM
24 angiocentric glioma 9.8 S100B VIM
25 juvenile xanthogranuloma 9.8 S100B VIM
26 pleomorphic liposarcoma 9.8 S100B VIM
27 cutaneous fibrous histiocytoma 9.8 S100B VIM
28 perineurioma 9.8 S100B VIM
29 spindle cell sarcoma 9.8 S100B VIM
30 odontogenic myxoma 9.8 S100B VIM
31 granular cell tumor 9.8 S100B VIM
32 dendritic cell tumor 9.8 S100B VIM
33 multiple sclerosis 9.8
34 peritonitis 9.8
35 neural tube defects 9.8
36 diastematomyelia 9.8
37 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.8
38 myelomeningocele 9.8
39 epidural abscess 9.8
40 synostosis 9.8
41 cervicitis 9.8
42 neurofibrosarcoma 9.8
43 craniopharyngioma 9.8
44 embryonal sarcoma 9.8 S100B VIM
45 cerebral primitive neuroectodermal tumor 9.8 S100B VIM
46 hemangiopericytoma, malignant 9.8 S100B VIM
47 gemistocytic astrocytoma 9.7 PTEN S100B
48 hidradenocarcinoma 9.7 S100B VIM
49 mixed type thymoma 9.7 PTEN S100B
50 polymorphous low-grade adenocarcinoma 9.7 S100B VIM

Graphical network of the top 20 diseases related to Hydromyelia:



Diseases related to Hydromyelia

Symptoms & Phenotypes for Hydromyelia

GenomeRNAi Phenotypes related to Hydromyelia according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 S100B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.64 VIM
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.64 PTEN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.64 PTEN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.64 PTEN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.64 PTEN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.64 VIM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.64 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.64 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 PTEN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.64 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.64 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.64 PTEN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 PTEN S100B VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 S100B VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.64 PTEN
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.5 S100B
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.5 S100B
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.5 S100B
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.5 S100B
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.5 PTEN S100B
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.5 PTEN

Drugs & Therapeutics for Hydromyelia

Search Clinical Trials , NIH Clinical Center for Hydromyelia

Genetic Tests for Hydromyelia

Anatomical Context for Hydromyelia

MalaCards organs/tissues related to Hydromyelia:

41
Spinal Cord, Brain, Bone

Publications for Hydromyelia

Articles related to Hydromyelia:

(show top 50) (show all 67)
# Title Authors Year
1
Curved Planar Reformation for the Evaluation of Hydromyelia in Patients with Scoliosis Associated with Spinal Dysraphism. ( 28604485 )
2017
2
Hydromyelia in a Japanese Black calf. ( 29081477 )
2017
3
Symptomatic Outcome after Bone-only Suboccipital Decompression in Adult Patients with Chiari Type I Malformations in the Absence of Hydromyelia or Hydrocephalus. ( 28437811 )
2017
4
The central nervous system pressure histogram in hydrocephalus and hydromyelia. ( 29055384 )
2017
5
Inverted V sign in hydromyelia with Chiari type 1 malformation. ( 22826022 )
2013
6
Spondylocarpotarsal synostosis with hydromyelia, mega cisterna magna, and pachydermoperiostosis. ( 22561843 )
2012
7
Hydromyelia associated with spinal lipoma of the conus: case report. ( 20802384 )
2010
8
Hydromyelia secondary to spinal epidural abscess. A case report. ( 24148595 )
2010
9
Defining the line between hydromyelia and syringomyelia. A differentiation is possible based on electrophysiological and magnetic resonance imaging studies. ( 19533016 )
2010
10
Acute presentation of hydromyelia in a child. ( 16944053 )
2006
11
Pre- and post-operative hydromyelia in spinal dysraphism. ( 15490146 )
2005
12
Fluid in the flute: Reversible hydromyelia. ( 15972219 )
2005
13
Reversible cervical hydromyelia in subacute combined degeneration. ( 16087892 )
2005
14
Extensive hydromyelia. ( 16139738 )
2005
15
Regional ependymal upregulation of vimentin in Chiari II malformation, aqueductal stenosis, and hydromyelia. ( 15255035 )
2004
16
Delayed resolution of Chiari I-associated hydromyelia after posterior fossa decompression: case report and review of the literature. ( 16933383 )
2004
17
Embryonic hydromyelia: cystic dilatation of the lumbosacral neural tube in human embryos. ( 11907805 )
2002
18
Hydromyelia in a Reeves' muntjac (Muntiacus reevesi). ( 12462493 )
2002
19
Gastrointestinal dysfunction associated with syringomyelia and hydromyelia. ( 10896075 )
2000
20
Hydromyelia in a child with chiari II. ( 10971196 )
2000
21
Effects of posterior fossa decompression with and without duraplasty on Chiari malformation-associated hydromyelia. ( 10834643 )
2000
22
Idiopathic localized hydromyelia: dilatation of the central canal of the spinal cord of probable congenital origin. ( 10348436 )
1999
23
Treatment of hydromyelia in spina bifida. ( 9842864 )
1998
24
Anatomy of the spinal cord in patients with meningomyelocele with and without hypoplasia or hydromyelia. ( 9926318 )
1998
25
Reversible hydromyelia in a synchronised swimmer with recurrent thoracic girdle pains. ( 9771802 )
1998
26
Presentation and management of hydromyelia in children with Chiari type-II malformation. ( 9419035 )
1997
27
Hydromyelia in the dog. ( 9238767 )
1997
28
Hydromyelia and Chiari malformation in children and adolescents. ( 18644262 )
1996
29
Experimental hydrocephalus and hydromyelia: a new insight in mechanism of their development. ( 8869715 )
1996
30
Multiple sclerosis with hydromyelia demonstrated at autopsy. ( 8815171 )
1996
31
Acquired Chiari-I malformation and hydromyelia secondary to a giant craniopharyngioma. ( 7547457 )
1995
32
Spontaneous pneumocephalus in a newborn infant with myelomeningocele and hydromyelia. ( 7926325 )
1994
33
Case of the day. 1. Diagnosis: tethered spinal cord with hydromyelia terminating at a lipoma. ( 7933003 )
1994
34
Hydromyelia associated with a posterior fossa cyst. ( 8235977 )
1993
35
Chiari malformation hydromyelia vs. syringomyelia. ( 1588414 )
1992
36
Hydromyelic hydrocephalus. Correlation of hydromyelia with various stages of hydrocephalus in postshunt isolated compartments. ( 1993901 )
1991
37
Chiari I malformations and hydromyelia--complications. ( 1819330 )
1991
38
Management of hydromyelia. ( 2797394 )
1989
39
Charcot shoulder as the initial symptom in Arnold-Chiari malformation with hydromyelia: case report. ( 3265183 )
1988
40
Hydromyelia associated with arrested hydrocephalus. ( 3352930 )
1988
41
Syringomyelia and hydromyelia. ( 3344082 )
1988
42
Percutaneous balloon myelotomy for treatment of hydromyelia: technical note. ( 3140630 )
1988
43
Hydromyelia: a critical review. ( 3042131 )
1988
44
Acquired hydrocephalus and hydromyelia in a cat with feline infectious peritonitis: A case report and brief review. ( 17423201 )
1988
45
Magnetic resonance imaging in the differentiation of spinal cord tumours and hydromyelia. ( 2980463 )
1986
46
Acquired scoliosis associated with hydromyelia and syringomyelia in two dogs. ( 3771361 )
1986
47
Concurrent hydromyelia and diastematomyelia. ( 3085450 )
1986
48
Hydromyelia complicating Apert's syndrome: a case report. ( 4022292 )
1985
49
MR imaging of syringomyelia and hydromyelia. ( 3873795 )
1985
50
[Isolated cervicothoracic spinal amyotrophy caused by hydromyelia. Stabilization by a ventricular shunt]. ( 6710016 )
1984

Variations for Hydromyelia

Expression for Hydromyelia

Search GEO for disease gene expression data for Hydromyelia.

Pathways for Hydromyelia

Pathways related to Hydromyelia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 PTEN VIM
2 10.52 S100B VIM

GO Terms for Hydromyelia

Biological processes related to Hydromyelia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 PTEN S100B
2 cellular response to hypoxia GO:0071456 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.62 PTEN S100B

Molecular functions related to Hydromyelia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 PTEN S100B VIM

Sources for Hydromyelia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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