MCID: HYD034
MIFTS: 28

Hydromyelia

Categories: Neuronal diseases

Aliases & Classifications for Hydromyelia

MalaCards integrated aliases for Hydromyelia:

Name: Hydromyelia 55
Hydrorhachis 74

Classifications:



External Ids:

ICD10 34 Q06.4
UMLS 74 C0152444

Summaries for Hydromyelia

NINDS : 55 Hydromyelia refers to an abnormal widening of the central canal of the spinal cord that creates a cavity in which cerebrospinal fluid (commonly known as spinal fluid) can accumulate.  As spinal fluid builds up, it may put abnormal pressure on the spinal cord and damage nerve cells and their connections.  Hydromyelia is sometimes used interchangeably with syringomyelia, the name for a condition that also involves cavitation in the spinal cord.  In hydromyelia, the cavity that forms is connected to the fourth ventricle in the brain, and is almost always associated in infants and children with hydrocephalus or birth defects such as Chiari Malformation II and Dandy-Walker syndrome.  Syringomyelia, however, features a closed cavity and occurs primarily in adults, the majority of whom have Chiari Malformation type 1 or have experienced spinal cord trauma.   Symptoms, which may occur over time, include weakness of the hands and arms, stiffness in the legs; and sensory loss in the neck and arms. Some individuals have severe pain in the neck and arms. Diagnosis is made by magnetic resonance imaging (MRI), which reveals abnormalities in the anatomy of the spinal cord..   

MalaCards based summary : Hydromyelia, also known as hydrorhachis, is related to syringohydromyelia and cowden syndrome 1. An important gene associated with Hydromyelia is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are MicroRNAs in cancer and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hydromyelia

Diseases related to Hydromyelia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 syringohydromyelia 11.3
2 cowden syndrome 1 11.1
3 syringomyelia 10.4
4 hydrocephalus 10.3
5 chiari malformation 10.3
6 scoliosis 10.2
7 familial syringomyelia 10.1
8 primary syringomyelia 10.1
9 chiari malformation type ii 10.1
10 multiple sclerosis 10.0
11 scoliosis, isolated 1 10.0
12 neural tube defects 10.0
13 diastematomyelia 10.0
14 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.0
15 idiopathic scoliosis 10.0
16 myelomeningocele 10.0
17 epidural abscess 10.0
18 synostosis 10.0
19 neurofibrosarcoma 10.0
20 craniopharyngioma 10.0
21 peritonitis 10.0
22 ependymoma 9.9 S100B VIM
23 bednar tumor 9.9 S100B VIM
24 primary hepatic neuroendocrine carcinoma 9.9 S100B VIM
25 syringocystadenoma papilliferum 9.9 S100B VIM
26 ossifying fibromyxoid tumor 9.9 S100B VIM
27 fibrous meningioma 9.9 S100B VIM
28 carcinosarcoma 9.9 PTEN VIM
29 chordoid meningioma 9.9 S100B VIM
30 eccrine porocarcinoma 9.9 S100B VIM
31 myxopapillary ependymoma 9.9 S100B VIM
32 monophasic synovial sarcoma 9.9 S100B VIM
33 syringoma 9.9 S100B VIM
34 angiocentric glioma 9.9 S100B VIM
35 juvenile xanthogranuloma 9.9 S100B VIM
36 pleomorphic liposarcoma 9.9 S100B VIM
37 amelanotic melanoma 9.9 S100B VIM
38 cutaneous fibrous histiocytoma 9.9 S100B VIM
39 fibrous histiocytoma 9.9 S100B VIM
40 perineurioma 9.9 S100B VIM
41 spindle cell sarcoma 9.9 S100B VIM
42 odontogenic myxoma 9.9 S100B VIM
43 granular cell tumor 9.9 S100B VIM
44 dendritic cell tumor 9.9 S100B VIM
45 embryonal sarcoma 9.9 S100B VIM
46 cerebral primitive neuroectodermal tumor 9.9 S100B VIM
47 gemistocytic astrocytoma 9.9 PTEN S100B
48 hidradenocarcinoma 9.9 S100B VIM
49 polymorphous low-grade adenocarcinoma 9.9 S100B VIM
50 mixed type thymoma 9.9 PTEN S100B

Graphical network of the top 20 diseases related to Hydromyelia:



Diseases related to Hydromyelia

Symptoms & Phenotypes for Hydromyelia

GenomeRNAi Phenotypes related to Hydromyelia according to GeneCards Suite gene sharing:

27 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 S100B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.64 VIM
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.64 PTEN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.64 PTEN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.64 PTEN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.64 PTEN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.64 VIM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.64 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.64 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 PTEN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.64 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.64 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.64 PTEN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 PTEN S100B VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 S100B VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.64 PTEN
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.5 S100B
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.5 S100B
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.5 S100B
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.5 S100B
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.5 PTEN S100B
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.5 PTEN

Drugs & Therapeutics for Hydromyelia

Search Clinical Trials , NIH Clinical Center for Hydromyelia

Genetic Tests for Hydromyelia

Anatomical Context for Hydromyelia

MalaCards organs/tissues related to Hydromyelia:

42
Spinal Cord, Brain, Bone

Publications for Hydromyelia

Articles related to Hydromyelia:

(show top 50) (show all 68)
# Title Authors Year
1
Clinical Relevance of Preoperative MRI in Adolescent Idiopathic Scoliosis: Is Hydromyelia a Predictive Factor of Intraoperative Electrophysiological Monitoring Alterations? ( 30913042 )
2019
2
Curved Planar Reformation for the Evaluation of Hydromyelia in Patients with Scoliosis Associated with Spinal Dysraphism. ( 28604485 )
2017
3
Hydromyelia in a Japanese Black calf. ( 29081477 )
2017
4
Symptomatic Outcome after Bone-only Suboccipital Decompression in Adult Patients with Chiari Type I Malformations in the Absence of Hydromyelia or Hydrocephalus. ( 28437811 )
2017
5
The central nervous system pressure histogram in hydrocephalus and hydromyelia. ( 29055384 )
2017
6
Inverted V sign in hydromyelia with Chiari type 1 malformation. ( 22826022 )
2013
7
Spondylocarpotarsal synostosis with hydromyelia, mega cisterna magna, and pachydermoperiostosis. ( 22561843 )
2012
8
Hydromyelia associated with spinal lipoma of the conus: case report. ( 20802384 )
2010
9
Hydromyelia secondary to spinal epidural abscess. A case report. ( 24148595 )
2010
10
Defining the line between hydromyelia and syringomyelia. A differentiation is possible based on electrophysiological and magnetic resonance imaging studies. ( 19533016 )
2010
11
Acute presentation of hydromyelia in a child. ( 16944053 )
2006
12
Pre- and post-operative hydromyelia in spinal dysraphism. ( 15490146 )
2005
13
Fluid in the flute: Reversible hydromyelia. ( 15972219 )
2005
14
Reversible cervical hydromyelia in subacute combined degeneration. ( 16087892 )
2005
15
Extensive hydromyelia. ( 16139738 )
2005
16
Regional ependymal upregulation of vimentin in Chiari II malformation, aqueductal stenosis, and hydromyelia. ( 15255035 )
2004
17
Delayed resolution of Chiari I-associated hydromyelia after posterior fossa decompression: case report and review of the literature. ( 16933383 )
2004
18
Embryonic hydromyelia: cystic dilatation of the lumbosacral neural tube in human embryos. ( 11907805 )
2002
19
Hydromyelia in a Reeves' muntjac (Muntiacus reevesi). ( 12462493 )
2002
20
Gastrointestinal dysfunction associated with syringomyelia and hydromyelia. ( 10896075 )
2000
21
Hydromyelia in a child with chiari II. ( 10971196 )
2000
22
Effects of posterior fossa decompression with and without duraplasty on Chiari malformation-associated hydromyelia. ( 10834643 )
2000
23
Idiopathic localized hydromyelia: dilatation of the central canal of the spinal cord of probable congenital origin. ( 10348436 )
1999
24
Treatment of hydromyelia in spina bifida. ( 9842864 )
1998
25
Anatomy of the spinal cord in patients with meningomyelocele with and without hypoplasia or hydromyelia. ( 9926318 )
1998
26
Reversible hydromyelia in a synchronised swimmer with recurrent thoracic girdle pains. ( 9771802 )
1998
27
Presentation and management of hydromyelia in children with Chiari type-II malformation. ( 9419035 )
1997
28
Hydromyelia in the dog. ( 9238767 )
1997
29
Hydromyelia and Chiari malformation in children and adolescents. ( 18644262 )
1996
30
Experimental hydrocephalus and hydromyelia: a new insight in mechanism of their development. ( 8869715 )
1996
31
Multiple sclerosis with hydromyelia demonstrated at autopsy. ( 8815171 )
1996
32
Acquired Chiari-I malformation and hydromyelia secondary to a giant craniopharyngioma. ( 7547457 )
1995
33
Spontaneous pneumocephalus in a newborn infant with myelomeningocele and hydromyelia. ( 7926325 )
1994
34
Case of the day. 1. Diagnosis: tethered spinal cord with hydromyelia terminating at a lipoma. ( 7933003 )
1994
35
Hydromyelia associated with a posterior fossa cyst. ( 8235977 )
1993
36
Chiari malformation hydromyelia vs. syringomyelia. ( 1588414 )
1992
37
Hydromyelic hydrocephalus. Correlation of hydromyelia with various stages of hydrocephalus in postshunt isolated compartments. ( 1993901 )
1991
38
Chiari I malformations and hydromyelia--complications. ( 1819330 )
1991
39
Management of hydromyelia. ( 2797394 )
1989
40
Charcot shoulder as the initial symptom in Arnold-Chiari malformation with hydromyelia: case report. ( 3265183 )
1988
41
Hydromyelia associated with arrested hydrocephalus. ( 3352930 )
1988
42
Syringomyelia and hydromyelia. ( 3344082 )
1988
43
Percutaneous balloon myelotomy for treatment of hydromyelia: technical note. ( 3140630 )
1988
44
Hydromyelia: a critical review. ( 3042131 )
1988
45
Acquired hydrocephalus and hydromyelia in a cat with feline infectious peritonitis: A case report and brief review. ( 17423201 )
1988
46
Magnetic resonance imaging in the differentiation of spinal cord tumours and hydromyelia. ( 2980463 )
1986
47
Acquired scoliosis associated with hydromyelia and syringomyelia in two dogs. ( 3771361 )
1986
48
Concurrent hydromyelia and diastematomyelia. ( 3085450 )
1986
49
Hydromyelia complicating Apert's syndrome: a case report. ( 4022292 )
1985
50
MR imaging of syringomyelia and hydromyelia. ( 3873795 )
1985

Variations for Hydromyelia

Expression for Hydromyelia

Search GEO for disease gene expression data for Hydromyelia.

Pathways for Hydromyelia

Pathways related to Hydromyelia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 PTEN VIM
2 10.52 S100B VIM

GO Terms for Hydromyelia

Biological processes related to Hydromyelia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 9.32 PTEN S100B
2 central nervous system development GO:0007417 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.62 PTEN S100B

Molecular functions related to Hydromyelia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 PTEN S100B VIM

Sources for Hydromyelia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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