MCID: HYD034
MIFTS: 26

Hydromyelia

Categories: Neuronal diseases

Aliases & Classifications for Hydromyelia

MalaCards integrated aliases for Hydromyelia:

Name: Hydromyelia 53 32
Hydrorhachis 70

Classifications:



External Ids:

ICD10 32 Q06.4
UMLS 70 C0152444

Summaries for Hydromyelia

NINDS : 53 Hydromyelia refers to an abnormal widening of the central canal of the spinal cord that creates a cavity in which cerebrospinal fluid (commonly known as spinal fluid) can accumulate.  As spinal fluid builds up, it may put abnormal pressure on the spinal cord and damage nerve cells and their connections.  Hydromyelia is sometimes used interchangeably with syringomyelia, the name for a condition that also involves cavitation in the spinal cord.  In hydromyelia, the cavity that forms is connected to the fourth ventricle in the brain, and is almost always associated in infants and children with hydrocephalus or birth defects such as Chiari Malformation II and Dandy-Walker syndrome.  Syringomyelia, however, features a closed cavity and occurs primarily in adults, the majority of whom have Chiari Malformation type 1 or have experienced spinal cord trauma.   Symptoms, which may occur over time, include weakness of the hands and arms, stiffness in the legs; and sensory loss in the neck and arms. Some individuals have severe pain in the neck and arms. Diagnosis is made by magnetic resonance imaging (MRI), which reveals abnormalities in the anatomy of the spinal cord..

MalaCards based summary : Hydromyelia, also known as hydrorhachis, is related to hydrocephalus and cellular ependymoma. An important gene associated with Hydromyelia is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord, cerebellum and pineal, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Syringomyelia is a generic term referring to a disorder in which a cyst or cavity forms within the... more...

Related Diseases for Hydromyelia

Diseases related to Hydromyelia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 30.2 S100B PTEN
2 cellular ependymoma 29.5 VIM S100B
3 malignant peripheral nerve sheath tumor 29.3 VIM S100B
4 syringohydromyelia 11.2
5 syringomyelia, noncommunicating isolated 11.1
6 cowden syndrome 1 10.9
7 syringomyelia 10.5
8 chiari malformation 10.4
9 scoliosis 10.3
10 myelomeningocele 10.2
11 lipomatosis, multiple 10.1
12 chiari malformation type ii 10.1
13 pleomorphic lipoma 10.1
14 neural tube defects 10.0
15 spinal arachnoiditis 10.0
16 arachnoiditis 10.0
17 paraplegia 10.0
18 spasticity 10.0
19 neuroendocrine carcinoma 10.0 S100B PTEN
20 gemistocytic astrocytoma 10.0 S100B PTEN
21 dandy-walker syndrome 10.0
22 diastematomyelia 10.0
23 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.0
24 tethered spinal cord syndrome 10.0
25 myelitis 10.0
26 ganglioneuroma 9.9 S100B PTEN
27 dedifferentiated liposarcoma 9.9 S100B PTEN
28 arteriovenous malformation 9.9 S100B PTEN
29 bednar tumor 9.9 VIM S100B
30 primary hepatic neuroendocrine carcinoma 9.9 VIM S100B
31 familial syringomyelia 9.9
32 primary syringomyelia 9.9
33 angiocentric glioma 9.9 VIM S100B
34 pilocytic astrocytoma 9.9 S100B PTEN
35 cutaneous leiomyosarcoma 9.9 VIM S100B
36 leiomyosarcoma 9.9 VIM S100B
37 odontogenic myxoma 9.9 VIM S100B
38 chordoid meningioma 9.9 VIM S100B
39 embryonal sarcoma 9.9 VIM S100B
40 neurofibromatosis, type i 9.9 S100B PTEN
41 ossifying fibromyxoid tumor 9.9 VIM S100B
42 polymorphous low-grade adenocarcinoma 9.9 VIM S100B
43 eccrine porocarcinoma 9.9 VIM S100B
44 dendritic cell tumor 9.9 VIM S100B
45 fibrous meningioma 9.9 VIM S100B
46 spiradenoma 9.9 VIM S100B
47 optic nerve glioma 9.9 VIM S100B
48 monophasic synovial sarcoma 9.9 VIM S100B
49 clear cell meningioma 9.9 VIM S100B
50 syringoma 9.9 VIM S100B

Graphical network of the top 20 diseases related to Hydromyelia:



Diseases related to Hydromyelia

Symptoms & Phenotypes for Hydromyelia

GenomeRNAi Phenotypes related to Hydromyelia according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 VIM
2 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 PTEN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.53 PTEN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.53 PTEN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.53 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.53 VIM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.53 S100B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.53 PTEN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.53 PTEN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.53 S100B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 PTEN VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-66 9.53 PTEN S100B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.53 PTEN
14 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.53 PTEN
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.43 S100B
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.43 S100B
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.43 S100B
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 9.43 PTEN
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.43 S100B
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.43 S100B

Drugs & Therapeutics for Hydromyelia

Search Clinical Trials , NIH Clinical Center for Hydromyelia

Genetic Tests for Hydromyelia

Anatomical Context for Hydromyelia

MalaCards organs/tissues related to Hydromyelia:

40
Spinal Cord, Cerebellum, Pineal, Skin

Publications for Hydromyelia

Articles related to Hydromyelia:

(show top 50) (show all 242)
# Title Authors PMID Year
1
Clinical cases of amyotrophic lateral sclerosis concurrent with hydromyelia. 61
33768891 2021
2
Scoliosis in spinal muscular atrophy: is the preoperative magnetic resonance imaging necessary? 61
32495206 2020
3
Syringomyelia and hydromyelia: Current understanding and neurosurgical management. 61
32826067 2020
4
Syringomyelia in Patient with Concurrent Posttraumatic Hydrocephalus and Tethered Spinal Cord: Implications for Surgical Management. 61
32156596 2020
5
Early-onset cerebellar ataxia in a patient with CMT2A2. 61
32532879 2020
6
Correlation of hydromyelia with subarachnoid hemorrhage-related hydrocephalus: an experimental study. 61
32514658 2020
7
MINIMALLY INVASIVE TREATMENT OF IDIOPATHIC SYRINGOMYELIA USING MYRINGOTOMY T-TUBES: A CASE REPORT AND TECHNICAL NOTE. 61
32724291 2020
8
Management of Chiari I malformation in children: personal opinions. 61
31053998 2019
9
Clinical Relevance of Preoperative MRI in Adolescent Idiopathic Scoliosis: Is Hydromyelia a Predictive Factor of Intraoperative Electrophysiological Monitoring Alterations? 61
30913042 2019
10
Chiari Malformations. 61
30610307 2019
11
An Exceptional Neurosurgical Presentation of a Patient with Osteopetrosis. 61
29935324 2018
12
Spontaneous Pneumocephalus Secondary to Leaking Myelomeningocele. 61
30271466 2018
13
Chiari type I malformation of infants and toddlers. 61
29396718 2018
14
Curved Planar Reformation for the Evaluation of Hydromyelia in Patients With Scoliosis Associated With Spinal Dysraphism. 61
28604485 2018
15
Characterization of spinal cord diffusion tensor imaging metrics in clinically asymptomatic pediatric subjects with incidental congenital lesions. 61
29928513 2018
16
Hydromyelia in a Japanese Black calf. 61
29081477 2017
17
The central nervous system pressure histogram in hydrocephalus and hydromyelia. 61
29055384 2017
18
Symptomatic Outcome after Bone-only Suboccipital Decompression in Adult Patients with Chiari Type I Malformations in the Absence of Hydromyelia or Hydrocephalus. 61
28437811 2017
19
Diagnostic value of ultrasonography in spinal abnormalities among children with neurogenic bladder. 61
28848632 2017
20
Spinal Cord Hamartomatous Myelodysplasia in 2 Horses With Clinical Neurologic Deficits. 61
26917551 2016
21
Hereditary spastic paraplegia: Novel mutations and expansion of the phenotype variability in SPG56. 61
26936192 2016
22
PROGRESSIVE SYRINGOHYDROMYELIA AND DEGENERATIVE AXONOPATHY IN A BOBCAT (LYNX RUFUS) FOLLOWING SURGICAL CORRECTION OF A CHIARI-LIKE MALFORMATION. 61
27010296 2016
23
Syringomyelia: a practical, clinical concept for classification. 61
25236931 2014
24
How we developed, at the Centre/Institute for Neuromuscular Diseases, differential diagnostics of Spinal Muscle Atrophies / Amyotrophic Lateral Sclerosis (SMA/ALS) and tried to influence the development of the disease. 61
25709383 2014
25
Charcot-Marie-Tooth disease type 2A: from typical to rare phenotypic and genotypic features. 61
24957169 2014
26
Diffusion tensor imaging in pediatric Chiari type I malformation. 61
24825432 2014
27
Toxoplasmosis-associated abortion in an alpaca (Vicugna pacos) fetus. 61
25000722 2014
28
Spontaneous spinal epidural hematoma in infancy: review of the literature and the "seventh" case report. 61
23786707 2013
29
Neuropathology of brain and spinal malformations in a case of monosomy 1p36. 61
24252393 2013
30
Inverted V sign in hydromyelia with Chiari type 1 malformation. 61
22826022 2013
31
Spondylocarpotarsal synostosis with hydromyelia, mega cisterna magna, and pachydermoperiostosis. 61
22561843 2012
32
Terminal myelocystocele: surgical observations and theory of embryogenesis. 61
22270234 2012
33
Experimental syringohydromyelia induced by adhesive arachnoiditis in the rabbit: changes in the blood-spinal cord barrier, neuroinflammatory foci, and syrinx formation. 61
22439613 2012
34
Spinal pilocytic astrocytoma: MR imaging findings at first presentation and following surgery. 61
20478675 2011
35
MRI findings, surgical treatment and follow-up of a myelomeningocele with tethered spinal cord syndrome in a cat. 61
21439878 2011
36
Acute central canal dilatation after minimally invasive lateral cervical decompression through the Frykholm approach. 61
21519303 2011
37
Syringohydromyelia in horses: 3 cases. 61
21532819 2011
38
Diastematomyelia and tumor in adults: report of two cases and literature review. 61
21030887 2010
39
Hydromyelia associated with spinal lipoma of the conus: case report. 61
20802384 2010
40
Hydromyelia secondary to spinal epidural abscess. A case report. 61
24148595 2010
41
Defining the line between hydromyelia and syringomyelia. A differentiation is possible based on electrophysiological and magnetic resonance imaging studies. 61
19533016 2010
42
Cystic spinal dysraphism of the cervical region: experience with eight cases including double cervical and lumbosacral meningoceles. 61
20453561 2010
43
Papillary tumor of the pineal region of a dog. 61
19901302 2009
44
Spinal dysraphisms of the cervicothoracic region in childhood. 61
19847762 2009
45
Segmental hypoplasia of the spinal cord in a Japanese black calf. 61
19346703 2009
46
Aggressive surgical management of patients with Chiari II malformation and brainstem dysfunction. 61
19907196 2009
47
Care of the adolescent with spina bifida. 61
19041463 2008
48
Spinal sonography in infants with cutaneous birth markers in the lumbo-sacral region--an important sign of occult spinal dysrhaphism and tethered cord. 61
17610175 2008
49
Split-cord malformation and accompanying anomalies. 61
18206241 2008
50
A new concept in the electrophysiological evaluation of syringomyelia. 61
18518671 2008

Variations for Hydromyelia

Expression for Hydromyelia

Search GEO for disease gene expression data for Hydromyelia.

Pathways for Hydromyelia

Pathways related to Hydromyelia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 VIM S100B

GO Terms for Hydromyelia

Biological processes related to Hydromyelia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.16 S100B PTEN
2 negative regulation of neuron projection development GO:0010977 8.96 VIM PTEN
3 learning or memory GO:0007611 8.62 S100B PTEN

Molecular functions related to Hydromyelia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 VIM S100B PTEN

Sources for Hydromyelia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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