Categories: Nephrological diseases

Aliases & Classifications for Hydronephrosis

Summaries for Hydronephrosis

MalaCards based summary : Hydronephrosis is related to congenital anomalies of kidney and urinary tract 2 and ureteral obstruction. An important gene associated with Hydronephrosis is WFS1 (Wolframin ER Transmembrane Glycoprotein), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Interleukin-4 and 13 signaling. The drugs Midazolam and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and spinal cord, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 73 Hydronephrosis describes hydrostatic dilation of the renal pelvis and calyces as a result of obstruction... more...

Related Diseases for Hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 673)
# Related Disease Score Top Affiliating Genes
1 congenital anomalies of kidney and urinary tract 2 32.9 TSHZ3 TGFB1 AQP2
2 ureteral obstruction 31.7 TGFB1 SLC12A1 AQP2
3 vesicoureteral reflux 1 31.7 ZIC3 TGFB1 C12orf57 B2M ALB
4 urinary tract obstruction 31.6 TGFB1 EGF CCL2 B2M AQP2 ALB
5 pyelonephritis 31.6 IL6 CCL2 ALB
6 acute cystitis 31.4 IL6 CCL2 ALB
7 obstructive nephropathy 31.3 TGFB1 EGF ALB
8 cystitis 31.2 VEGFA IL6 EGF CCL2
9 diabetes insipidus 31.1 WFS1 SLC12A1 AQP2
10 acute kidney failure 31.1 EGF B2M ALB
11 appendicitis 31.0 IL6 CCL2 ALB
12 cystic kidney disease 31.0 EGF B2M AQP2 ALB
13 kidney disease 30.8 VEGFA TGFB1 SLC12A1 IL6 CCL2 B2M
14 bacteriuria 30.8 IL6 CCL2 ALB
15 proteinuria, chronic benign 30.8 VEGFA B2M ALB
16 pyuria 30.8 IL6 B2M ALB
17 pyelitis 30.8 IL6 B2M ALB
18 glomerulonephritis 30.7 TGFB1 CCL2 B2M ALB
19 peritonitis 30.7 IL6 CCL2 B2M ALB
20 uremia 30.6 IL6 B2M ALB
21 xanthogranulomatous pyelonephritis 30.6 EGF CCL2
22 intussusception 30.6 VEGFA IL6 ALB
23 nephrosclerosis 30.5 VEGFA TGFB1 CCL2
24 chronic kidney disease 30.5 VEGFA TGFB1 IL6 CCL2 B2M AQP2
25 end stage renal disease 30.5 VEGFA TGFB1 IL6 CCL2 B2M ALB
26 ureteral disease 30.4 TGFB1 IL6 CCL2 AQP2 ALB
27 syphilis 30.4 IL6 B2M ALB
28 diabetes mellitus 30.3 WFS1 VEGFA TGFB1 IL6 EGF CCL2
29 diarrhea 30.2 TGFB1 MME IL6 ALB
30 diffuse large b-cell lymphoma 30.2 VEGFA MME IL6 B2M
31 exanthem 30.2 VEGFA IL6 ALB
32 membranous nephropathy 30.2 MME IL6 B2M ALB
33 filariasis 30.2 VEGFA IL6 ALB
34 iga glomerulonephritis 30.1 TGFB1 IL6 CCL2 ALB
35 patent ductus arteriosus 1 30.1 ZIC3 VEGFA ALB
36 bone inflammation disease 30.1 VEGFA IL6 CCL2 ALB
37 peripheral artery disease 30.1 VEGFA IL6 CCL2
38 chorioamnionitis 30.1 VEGFA IL6 CCL2
39 congestive heart failure 30.1 VEGFA MME IL6 AQP2 ALB
40 autosomal dominant polycystic kidney disease 30.0 VEGFA TGFB1 EGF CCL2 AQP2 ALB
41 plasmacytoma 30.0 VEGFA IL6 B2M
42 liver cirrhosis 30.0 VEGFA TGFB1 IL6 AQP2 ALB
43 polycystic kidney disease 30.0 VEGFA TGFB1 EGF CCL2 B2M AQP2
44 distal arthrogryposis 29.9 SLC12A1 SETBP1 EGF ALB
45 osteoporosis 29.9 VEGFA TGFB1 IL6 EGF CCL2 B2M
46 hypertension, essential 29.7 VEGFA TGFB1 SLC12A1 MME IL6 EGF
47 urofacial syndrome 1 11.5
48 hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation 11.3
49 ehlers-danlos syndrome, musculocontractural type, 1 11.2
50 megacystis-microcolon-intestinal hypoperistalsis syndrome 11.1

Comorbidity relations with Hydronephrosis via Phenotypic Disease Network (PDN): (show all 37)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bladder Cancer
Bladder Neck Obstruction Candidiasis
Cervical Cancer Chronic Kidney Disease
Colorectal Cancer Cystitis
Cystitis Cystica Decubitus Ulcer
Deficiency Anemia Intestinal Obstruction
Iron Deficiency Anemia Kidney Disease
Nephrolithiasis, Uric Acid Nephrolithiasis, X-Linked Recessive, with Renal Failure
Nephrosclerosis Neurogenic Bladder
Neutropenia Ovarian Cancer
Paralytic Ileus Prostate Cancer
Prostatic Hypertrophy Protein-Energy Malnutrition
Pyelonephritis Radiation Cystitis
Rectosigmoid Junction Neoplasm Renal Pelvis Carcinoma
Ureter, Cancer of Ureterolithiasis
Urethral Benign Neoplasm Urethral Calculus
Urethral Stricture Urinary Tract Obstruction
Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Hydronephrosis:

Diseases related to Hydronephrosis

Symptoms & Phenotypes for Hydronephrosis

MGI Mouse Phenotypes related to Hydronephrosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.23 AQP2 CHN1 ID2 IL6 MME SETBP1
2 growth/size/body region MP:0005378 10.18 AQP2 B2M C12orf57 CHN1 EGF ID2
3 cardiovascular system MP:0005385 10.17 ALB B2M IL6 MME OSR1 SETBP1
4 homeostasis/metabolism MP:0005376 10.17 ALB AQP2 B2M C12orf57 CHN1 IL6
5 digestive/alimentary MP:0005381 10.06 ALB B2M EGF ID2 IL6 TGFB1
6 mortality/aging MP:0010768 10.06 ALB AQP2 B2M C12orf57 CHN1 ID2
7 integument MP:0010771 10 AQP2 B2M EGF ID2 IL6 MME
8 renal/urinary system MP:0005367 9.61 ALB AQP2 ID2 IL6 OSR1 SLC12A1
9 reproductive system MP:0005389 9.32 AQP2 B2M EGF ID2 IL6 OSR1

Drugs & Therapeutics for Hydronephrosis

Drugs for Hydronephrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Etomidate Approved Phase 4 33125-97-2 36339 667484
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
6 Neurotransmitter Agents Phase 4
7 Psychotropic Drugs Phase 4
8 Hypnotics and Sedatives Phase 4
9 GABA Modulators Phase 4
10 Anesthetics, Intravenous Phase 4
11 Hydrocortisone hemisuccinate Phase 4
12 Anesthetics, General Phase 4
13 Anti-Anxiety Agents Phase 4
14 Hydrocortisone 17-butyrate 21-propionate Phase 4
Alfuzosin Approved, Investigational Phase 3 81403-80-7 2092
16 Pharmaceutical Solutions Phase 3
17 Adrenergic alpha-Antagonists Phase 3
18 Adrenergic alpha-1 Receptor Antagonists Phase 3
19 Adrenergic Antagonists Phase 3
20 Adrenergic Agents Phase 3
Praziquantel Approved, Investigational, Vet_approved 55268-74-1 4891
Ibuprofen Approved 15687-27-1 3672
Levoleucovorin Approved, Investigational 68538-85-2 149436
Trimethoprim Approved, Vet_approved 738-70-5 5578
Cisplatin Approved Early Phase 1 15663-27-1 84093 441203 2767
Ipilimumab Approved Early Phase 1 477202-00-9
Durvalumab Approved, Investigational Early Phase 1 1428935-60-7
Ropivacaine Approved 84057-95-4 71273 175805
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
Tremelimumab Investigational Early Phase 1 745013-59-6
31 diuretics
32 Anthelmintics
33 Analgesics, Non-Narcotic
34 Analgesics
35 Antirheumatic Agents
36 Cyclooxygenase Inhibitors
37 Anti-Inflammatory Agents
38 Anti-Inflammatory Agents, Non-Steroidal
39 Brimonidine Tartrate 70359-46-5
40 Folic Acid Antagonists
41 Vitamin B9
42 Cytochrome P-450 Enzyme Inhibitors
43 Antiparasitic Agents
44 Vitamin B Complex
45 Antimalarials
46 Folate
47 Anti-Infective Agents
48 Antiprotozoal Agents
49 Immunoglobulins Early Phase 1
50 Antineoplastic Agents, Immunological Early Phase 1

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Phase 1 Study of Circadian Rhythm of Salivary Cortisol in Health Children ;Phase 2 Study of Circadian Rhythm of Salivary Cortisol of Children Undergoing Surgery Using Etomidate or Not Using Etomidate. Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
2 12-week, Multicenter, Open-label, Non-comparative Study to Investigate Pharmacodynamic and Safety of Alfuzosin 0.2 mg/kg/Day in the Treatment of Children and Adolescents 2 - 16 Years of Age With Hydronephrosis Associated With Elevated Detrusor Leak Point Pressure of Neuropathic Etiology Followed by a 40-week Open-label Extension Completed NCT00576823 Phase 3 Alfuzosin
3 Bladder Function Following Temporary Unilateral Cutaneous Ureterostomy - Long Term Follow up Unknown status NCT00546208
4 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
5 Sonographic Follow up in Newborns Diagnosed With Prenatal Hydronephrosis Unknown status NCT01780103
6 Effect of Per-cutaneous Nephrosotomy Drainage on Radioisotope Imaging of Hydronephrotic Kidneys Unknown status NCT03695991
7 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance in Children With Scintigraphically Prooved Obstruction. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431
8 Cortical Transit Time on Diuretic Renogram as an Early Marker of Significant Obstruction in Antenatally Detected Uretero-pelvic Junction Syndrome Unknown status NCT02812212
9 Optimal Method of Decompression of the Renal Collecting System in Acute Obstruction: a Prospective Randomised Trial Unknown status NCT02929160
10 Clinical Significance of Supranormal Differential Renal Function in the Recovery of Unilateral Hydronephrosis After Surgery: Long-term Results Completed NCT01839006
11 Emergency Department Targeted Ultrasound for the Detection of Hydronephrosis Completed NCT00555308
12 Prospective Pediatric Pyeloplasty Robotic Surgical Database Completed NCT00882544
13 Correlation of Hydronephrosis on Point of Care Ultrasound With CT Finding in Patients With Expected Renal Colic Completed NCT01349244
14 Hydro II: Emergency Department Ultrasound in Renal Colic Completed NCT01323842
15 Hydronephrosis After Anterior Lumbar Interbody Fusion (ALIF) Completed NCT02976870
16 Evaluation of Ultrasound Acoustic Radiation Force Impulse (ARFI)Shear Wave Velocity Imaging (SVI)in the Characterization of Pediatric Hydronephrosis Completed NCT01781845
17 Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis Completed NCT00568724
18 Simplified Diagnostic Algorithm for Evaluation of Neonates With Prenatally Detected Hydronephrosis Completed NCT01330511
19 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
20 Bedside Ultrasonography in Acute Patients With Suspected Kidney Involvement Completed NCT03873701
21 The Effects of Water Versus Saline on Absorption Rates and Visualization During Ureteroscopy Completed NCT03794102
22 The Influence of Transmission Season on Outcome of Schistosoma Haematobium Infection Treatment Among School Children in Urban and Peri-Urban Areas of Maputo and Matola, Mozambique Completed NCT00231322 praziquantel
23 Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community Completed NCT00591968
24 Evaluation of Ureteral Length Measurement by Computed Tomography (CT) to Actual Ureteral Length Measured by Ureteral Catheterization Completed NCT01542593
25 Dismembered Pyeloplasty With and Without After Coming Stent in Neonatal Ureteropelvic Junction Obstruction Completed NCT02138877
26 Sensitivity and Specificity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in an Emergency Room Population Completed NCT00786708
27 Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program Completed NCT03296280
28 Diagnostic Imaging of Acute Pyelonephritis - Part of the INDEED Study (Infectious Diseases in Emergency Departments) Recruiting NCT04651244
29 Minimizing the Utilization of Voiding Cystourethrography for Patients With Antenatal Hydronephrosis Recruiting NCT02825485
30 Ultrasonography Versus Fluoroscopic Guided Renal Access Recruiting NCT04090255
31 Effectiveness of Drainage of the Kidney by Percutaneous Nephrostomy Catheter Placement Vs. Retrograde Double J Catheter Placement in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis Recruiting NCT04594161
32 Double-blind, Placebo-controlled Randomized Controlled Trial of NSAID Prior to Ureteral Stent Removal in a Pediatric Population Recruiting NCT02140970 Ibuprofen;Placebo
33 Point-of-care Ultrasound in Finland Recruiting NCT03327688
34 Post-Marketing Follow-Up of Long-term Type Ureteral Stent Set Recruiting NCT04250090
35 Examining the Underlying Factors That Cause Ureteral Stent Discoloration in Japanese and Canadian Ureteral Stents Active, not recruiting NCT02007980
36 Hand-carried Ultrasound for Ruling Out Hydronephrosis in Acute Kidney Injury and Acute Kidney Disease Active, not recruiting NCT03774719
37 Antibiotic prophyLaxis Versus Placebo in Infants Diagnosed With Hydronephrosis Antenatally Active, not recruiting NCT01140516 Trimethoprim
38 A Pilot Pre-Surgical Study Evaluating Anti-PD-L1 Antibody (Durvalumab) Plus Anti-CTLA-4 (Tremelimumab) in Patients With Muscle-Invasive, High-Risk Urothelial Carcinoma Who Are Ineligible for Cisplatin-Based Neoadjuvant Chemotherapy Active, not recruiting NCT02812420 Early Phase 1
39 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction (LUTO): A Prospective Trial Active, not recruiting NCT03281798
40 Instillation of Renal Pelvis With 0.5% Iodophors for Patients With Calculous Pyonephrosis for I-stage PCNL : a Multicentre, Prospective, Open, Randomized Clinical Trial Not yet recruiting NCT03805542
41 Efficacy and Safety of Coated Metal Ureteral Stent in the Treatment of Radiation Induced Ureteral Stricture, A Prospective, Mutlcenter and Controlled Study Not yet recruiting NCT04441320
42 Ambulatory Blood Pressure Measurement in Children With Congenital Urine Flow Obstruction No longer available NCT00764543
43 A Prospective, Randomized Trial Comparing Previously Placed Nephrostomy Tract and Single Stage Percutaneous Nephrolithotomy and Its Effects on Infection and Bleeding Related Complications Terminated NCT00907946
44 Prospective Randomized Trial of Indwelling Double-J Ureteral Stent Versus Externalized Modified-Salle Stent for Pyeloplasty Terminated NCT02713633
45 The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine for the Management of Pain After Surgical Correction of Ureteropelvic Junction Stenosis Terminated NCT00930046
46 Ultrasonography Sensibilized by Oral Hydration and Hydronephrosis in Children. Is it Useful for Diagnosis and Follow up? Withdrawn NCT02086760
47 Comparison of Rapid Protocol Noncontrast MRI vs. Ultrasound in the Evaluation of Pediatric Hydronephrosis Withdrawn NCT01588340
48 Functional, Dynamic, and Anatomic MR Urography Withdrawn NCT00585767
49 The Impact of Ureteral Stents on Peristalsis Withdrawn NCT01739738

Search NIH Clinical Center for Hydronephrosis

Cochrane evidence based reviews: hydronephrosis

Genetic Tests for Hydronephrosis

Genetic tests related to Hydronephrosis:

# Genetic test Affiliating Genes
1 Hydronephrosis 29

Anatomical Context for Hydronephrosis

MalaCards organs/tissues related to Hydronephrosis:

Kidney, Prostate, Spinal Cord, Cervix, Bone, Colon, Breast

Publications for Hydronephrosis

Articles related to Hydronephrosis:

(show top 50) (show all 11513)
# Title Authors PMID Year
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. 61 54
11137441 2001
In fetuses with isolated hydronephrosis, urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) have a limited role in the prediction of postnatal renal function. 61 54
8994243 1996
Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo. 54 61
8589437 1995
[Evaluation of renal function and prediction of renal functional recovery in children with unilateral hydronephrosis using renal pelvic urine]. 61 54
1282579 1992
Inverted mucosa and avulsion ureteral injury in ureteroscopic procedure: A very rare complication of a common procedure in urology. 61
33665126 2021
Giant hydronephrosis secondary to ureteral calculi in adults: Case report and literature review. 61
33598407 2021
Preoperative risk stratification using plasma fibrinogen levels can predict lymphovascular invasion and poor prognosis in patients with upper urinary tract urothelial carcinoma. 61
33796291 2021
Hydronephrosis caused by kidney malrotation. 61
33489770 2021
Surgical treatment of retroiliac ectopic ureters with secondary hydronephrosis and hydroureter in a dog. 61
33754813 2021
Stage IVA cervical cancer: outcomes of disease related complications and treatment. 61
32920534 2021
A ten-year, single institution experience with percutaneous nephrostomy during pregnancy. 61
33212305 2021
Point-of-care ultrasound to reveal hydronephrosis in the emergency department: an observational, prospective, semi-blinded single-center study. 61
32732661 2021
Risk factors of febrile urinary tract infections following retrograde intrarenal surgery for renal stones. 61
33787599 2021
Diagnostic Test Characteristics of Ultrasound Based Hydronephrosis in Identifying Low Kidney Function in Young Patients with Spina Bifida: A Retrospective Cohort Study. 61
33207136 2021
Does Renal Function Remain Stable after Puberty in Children who underwent Ureteral Reimplantation due to Ureterovesical Junction Obstruction? 61
32450580 2021
Evaluation and fetal intervention in severe fetal hydronephrosis. 61
33651757 2021
Risk Factors, Diagnosis, and Treatment of Lymphocele After Renal Transplantation: A Retrospective Study. 61
33573817 2021
Ureteropelvic junction obstruction: diagnosis and management. 61
33470672 2021
Does Ureteral Stenting Increase the Risk of Metachronous Upper Tract Urothelial Carcinoma in Patients with Bladder Tumors? A Systematic Review and Meta-analysis. 61
33284711 2021
Endoscopic Ultrasound-guided Fine Needle Aspiration for the Diagnosis of Duodenal Stenosis Due to Urothelial Carcinoma. 61
32963164 2021
[Isolated fetal pericardial effusion follow-up: Should we worry?] 61
33781717 2021
[Clinical features of neurogenic bladder with vesicoureteral reflux in children]. 61
33691922 2021
Predictive score for vesicoureteral reflux in children with a first febrile urinary tract infection. 61
33745167 2021
Functional results of hautmann neobladder with chimney modification and wallace ureteroileal anastomosis: initial experience with 22 patients. 61
33146976 2021
Prevalence of high-risk bladder categorization with prenatal and postnatal myelomeningocele repair types. 61
33604950 2021
Understanding failures in getting it up: The prevalence and predictors of failed ureteral access in ureteroscopy. 61
32807285 2021
Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study. 61
33773965 2021
Robot-assisted segmental ureterectomy with psoas hitch ureteral reimplantation: Oncological, functional and perioperative outcomes of case series of a single centre. 61
33754620 2021
Excision of deep endometriosis nodules of the parametrium and sacral roots in 10 steps. 61
33766459 2021
Single stage Xi® robotic radical nephroureterectomy for upper tract urothelial carcinoma: surgical technique and outcomes. 61
33781022 2021
Acute kidney injury strongly influences renal function after radical nephroureterectomy for upper tract urothelial carcinoma: A single-centre experience. 61
33754601 2021
Antibiotic administration for negative midstream urine culture patients before percutaneous nephrolithotomy. 61
33710365 2021
Robotic upper tract surgery in infants 6 months or less: is there enough space? 61
33751338 2021
A new technique in the treatment of ureteroenteric anastomosis stricture: Repair of ureteroenteric anastomosis stricture with low lombotomy incision (retroperitoneal approach). 61
33743548 2021
Modern surgical strategies in the management of complex ureteral strictures. 61
33449575 2021
Role of urinary biomarkers for diagnosis and prognosis of kidney stone disease. 61
33394608 2021
Can ureteral wall thickness (UWT) be used as a potential parameter for decision-making in uncomplicated distal ureteral stones 5-10 mm in size? A prospective study. 61
33738575 2021
Unilateral T-shaped incomplete duplex nephrectomy in an adolescent under laparoscopy: A case report. 61
33761700 2021
Incidental discovery of endourethral clip migration 10 years after radical prostatectomy: A case report and review of the literature. 61
33715533 2021
Mid-trimester absent nasal bone and transient unilateral hydronephrosis associated with 16p13.3 microduplication. 61
33778969 2021
Maternal hydronephrosis in pregnant women without ureteral stones and characteristics of symptomatic cases who need treatment: A single-center prospective study with 1026 pregnant women. 61
33754607 2021
Effects of severe hydronephrosis on the outcomes of percutaneous nephrolithotomy with one-shot dilation method. 61
33709845 2021
Rare cause of asymptomatic giant hydronephrosis. 61
33753392 2021
Incidence of Urinary Tract Infections in Newborns with Spina Bifida: Is Antibiotic Prophylaxis Necessary? 61
33683941 2021
Case report: The theory of post-ileocystoplasty spherical configuration in patients with low-capacity bladder. 61
33721819 2021
Incidence and risk factors of venous thromboembolism after percutaneous nephrolithotomy: a single-center experience. 61
33725149 2021
Giant neonatal hydronephrosis of the upper pole of a complete duplicated renal system. 61
33715935 2021
Dietl crisis: Presentation and imaging findings in a 7-year-old boy. 61
33384756 2021
Inguinal hernia of the distal ureter causing hydronephrosis: A rare case. 61
33437644 2021
Duration of Ureteral Stenting Following Ureteroscopic Perforation in a Porcine Model. 61
32762262 2021

Variations for Hydronephrosis

ClinVar genetic disease variations for Hydronephrosis:

6 (show all 13)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 C12orf57 NM_138425.4(C12orf57):c.53-2A>G SNV Pathogenic 242885 rs1114167293 GRCh37: 12:7053637-7053637
GRCh38: 12:6944474-6944474
2 WFS1 NM_006005.3(WFS1):c.1999C>T (p.Gln667Ter) SNV Pathogenic 598973 rs771409809 GRCh37: 4:6303521-6303521
GRCh38: 4:6301794-6301794
3 TBX4 NM_001321120.2(TBX4):c.402G>A (p.Trp134Ter) SNV Pathogenic 638159 rs1603251494 GRCh37: 17:59544871-59544871
GRCh38: 17:61467510-61467510
4 overlap with 9 genes GRCh37/hg19 22q11.21(chr22:21075575-21454721) copy number loss Likely pathogenic 997075 GRCh37: 22:21075575-21454721
5 PGM1 NM_002633.3(PGM1):c.804T>A (p.Tyr268Ter) SNV Likely pathogenic 694645 rs1302961946 GRCh37: 1:64100621-64100621
GRCh38: 1:63634950-63634950
6 CHN1 NM_001822.7(CHN1):c.667G>A (p.Ala223Thr) SNV Likely pathogenic 598971 rs1558939623 GRCh37: 2:175689207-175689207
GRCh38: 2:174824479-174824479
7 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg) SNV Likely pathogenic 523513 rs1555706928 GRCh37: 18:42531919-42531919
GRCh38: 18:44951954-44951954
8 FLNA NM_001110556.2(FLNA):c.3934C>T (p.Arg1312Cys) SNV Uncertain significance 617640 rs781928289 GRCh37: X:153588145-153588145
GRCh38: X:154359777-154359777
9 KIF1A NM_001244008.1(KIF1A):c.3052C>T (p.His1018Tyr) SNV Uncertain significance 598972 rs1356639316 GRCh37: 2:241686664-241686664
GRCh38: 2:240747247-240747247
10 XDH NM_000379.4(XDH):c.3647C>A (p.Pro1216His) SNV Uncertain significance 335760 rs143981573 GRCh37: 2:31562482-31562482
GRCh38: 2:31339616-31339616
11 XDH NM_000379.4(XDH):c.1172C>T (p.Pro391Leu) SNV Uncertain significance 598996 rs1558697792 GRCh37: 2:31602803-31602803
GRCh38: 2:31379937-31379937
12 GATA4 NM_002052.5(GATA4):c.94G>C (p.Ala32Pro) SNV Uncertain significance 599008 rs773545065 GRCh37: 8:11565915-11565915
GRCh38: 8:11708406-11708406
13 ERF NM_006494.4(ERF):c.1636C>T (p.Arg546Ter) SNV Uncertain significance 599007 rs764412749 GRCh37: 19:42752628-42752628
GRCh38: 19:42248476-42248476

Expression for Hydronephrosis

Search GEO for disease gene expression data for Hydronephrosis.

Pathways for Hydronephrosis

GO Terms for Hydronephrosis

Cellular components related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.92 VEGFA TGFB1 EGF ALB

Biological processes related to Hydronephrosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.81 VEGFA TBX4 EGF CCL2
2 cellular protein metabolic process GO:0044267 9.78 WFS1 IL6 B2M ALB
3 positive regulation of gene expression GO:0010628 9.73 VEGFA TGFB1 OSR1 IL6 ID2 EGF
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.72 VEGFA TGFB1 IL6
5 platelet degranulation GO:0002576 9.62 VEGFA TGFB1 EGF ALB
6 positive regulation of epithelial cell proliferation GO:0050679 9.61 VEGFA TGFB1 OSR1
7 positive regulation of MAP kinase activity GO:0043406 9.58 VEGFA TGFB1 EGF
8 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.54 TGFB1 IL6
9 surfactant homeostasis GO:0043129 9.52 VEGFA TGFB1
10 positive regulation of vascular permeability GO:0043117 9.49 VEGFA TGFB1
11 positive regulation of protein localization to early endosome GO:1902966 9.46 VEGFA EGF
12 lung development GO:0030324 9.46 ZIC3 VEGFA TBX4 MME
13 positive regulation of epithelial tube formation GO:1905278 9.37 VEGFA EGF
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 VEGFA TGFB1 IL6 EGF
15 mammary gland alveolus development GO:0060749 8.8 VEGFA ID2 EGF

Molecular functions related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 VEGFA TGFB1 IL6 CCL2
2 growth factor activity GO:0008083 8.92 VEGFA TGFB1 IL6 EGF

Sources for Hydronephrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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