MCID: HYD002
MIFTS: 49

Hydronephrosis

Categories: Nephrological diseases

Aliases & Classifications for Hydronephrosis

Summaries for Hydronephrosis

MalaCards based summary : Hydronephrosis is related to congenital anomalies of kidney and urinary tract 2 and ureteral obstruction. An important gene associated with Hydronephrosis is C12orf57 (Chromosome 12 Open Reading Frame 57), and among its related pathways/superpathways are Immune response IFN gamma signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Hydrocortisone acetate and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include kidney, spinal cord and prostate, and related phenotypes are immune system and mortality/aging

Wikipedia : 76 Hydronephrosis describes urine-filled dilation of the renal pelvis and/or calyces as a result of... more...

Related Diseases for Hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
# Related Disease Score Top Affiliating Genes
1 congenital anomalies of kidney and urinary tract 2 33.4 TSHZ3 TGFB1 EGF
2 ureteral obstruction 30.4 TGFB1 SLC12A1 AQP2
3 pyelonephritis 30.4 NAGLU CCL2 ALB
4 obstructive nephropathy 30.0 TGFB1 EGF ALB
5 urinary tract obstruction 29.6 TGFB1 NAGLU EGF CCL2 B2M AQP2
6 peritonitis 29.5 CCL2 B2M ALB
7 autosomal dominant polycystic kidney disease 29.3 EGF CCL2 AQP2 ALB
8 kidney disease 29.3 TGFB1 NAGLU CCL2 B2M AQP2 ALB
9 hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation 12.3
10 coloboma porencephaly hydronephrosis 12.0
11 urofacial syndrome 1 11.9
12 visceral myopathy 11.2
13 ehlers-danlos syndrome, musculocontractural type, 1 11.2
14 carpenter syndrome 1 11.1
15 perlman syndrome 11.1
16 vacterl association, x-linked, with or without hydrocephalus 11.1
17 urethral obstruction sequence 11.0
18 ritscher-schinzel syndrome 1 11.0
19 raine syndrome 11.0
20 otopalatodigital syndrome, type ii 11.0
21 mesomelia-synostoses syndrome 11.0
22 genitopatellar syndrome 11.0
23 arterial calcification of infancy 11.0
24 kleefstra syndrome 11.0
25 al-gazali-donnai-mueller syndrome 11.0
26 desmoid tumor 11.0
27 ring chromosome 10 11.0
28 split hand urinary anomalies spina bifida 11.0
29 vesicoureteral reflux 1 10.3
30 horseshoe kidney 10.3
31 acute cystitis 10.2
32 bladder cancer 10.2
33 endometriosis 10.2
34 immunodeficiency 43 10.2 B2M ALB
35 orthostatic proteinuria 10.1 B2M ALB
36 diabetes insipidus, nephrogenic, autosomal 10.1
37 diabetes insipidus 10.1
38 diffuse glomerulonephritis 10.1 B2M ALB
39 kidney hypertrophy 10.1 TGFB1 ALB
40 cystic kidney disease 10.1 EGF B2M ALB
41 non-secretory myeloma 10.1 B2M ALB
42 acute kidney failure 10.1 EGF B2M ALB
43 diabetic foot ulcers 10.1 TGFB1 CCL2
44 fibrosclerosis, multifocal 10.1
45 stricture or kinking of ureter 10.1
46 acute kidney tubular necrosis 10.1 NAGLU B2M ALB
47 cystitis 10.1
48 actinomycosis 10.1
49 retroperitoneal fibrosis 10.1
50 danubian endemic familial nephropathy 10.1 B2M ALB

Comorbidity relations with Hydronephrosis via Phenotypic Disease Network (PDN): (show all 38)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bladder Cancer
Bladder Neck Obstruction Candidiasis
Cervical Cancer Chronic Kidney Failure
Colorectal Cancer Cystitis
Cystitis Cystica Decubitus Ulcer
Deficiency Anemia Intestinal Obstruction
Iron Deficiency Anemia Kidney Disease
Nephrolithiasis, Uric Acid Nephrolithiasis, X-Linked Recessive, with Renal Failure
Nephrosclerosis Neurogenic Bladder
Neutropenia Ovarian Cancer
Paralytic Ileus Prostate Cancer
Prostatic Hypertrophy Protein-Energy Malnutrition
Pyelonephritis Radiation Cystitis
Rectal Neoplasm Rectosigmoid Junction Neoplasm
Renal Pelvis Carcinoma Ureter, Cancer of
Ureterolithiasis Urethral Benign Neoplasm
Urethral Calculus Urethral Stricture
Urinary Tract Obstruction Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to Hydronephrosis

Symptoms & Phenotypes for Hydronephrosis

MGI Mouse Phenotypes related to Hydronephrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.02 B2M CCL2 EGF ID2 MME NAGLU
2 mortality/aging MP:0010768 9.97 ALB AQP2 B2M C12orf57 ID2 NAGLU
3 integument MP:0010771 9.96 AQP2 B2M EGF ID2 MME NAGLU
4 renal/urinary system MP:0005367 9.56 ALB AQP2 ID2 NAGLU OSR1 SLC12A1
5 reproductive system MP:0005389 9.28 AQP2 B2M EGF ID2 OSR1 SLC12A1

Drugs & Therapeutics for Hydronephrosis

Drugs for Hydronephrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4
Etomidate Approved Phase 4 33125-97-2 667484 36339
5
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
6
Silodosin Approved Phase 4 160970-54-7
7 GABA Agents Phase 4
8 Hydrocortisone 17-butyrate 21-propionate Phase 4
9 GABA Modulators Phase 4
10 Hydrocortisone-17-butyrate Phase 4
11 Adjuvants, Anesthesia Phase 4
12 Anesthetics, Intravenous Phase 4,Not Applicable
13 Central Nervous System Depressants Phase 4,Not Applicable
14 Anti-Anxiety Agents Phase 4
15 Anti-Inflammatory Agents Phase 4,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Tranquilizing Agents Phase 4
18 Psychotropic Drugs Phase 4
19 Anesthetics Phase 4,Not Applicable
20 Anesthetics, General Phase 4,Not Applicable
21 Hypnotics and Sedatives Phase 4,Not Applicable
22 Cortisol succinate Phase 4
23 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Phase 2
24 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2
25 Adrenergic Antagonists Phase 4,Phase 3,Phase 2
26 Adrenergic Agents Phase 4,Phase 3,Phase 2
27
Alfuzosin Approved, Investigational Phase 3 81403-80-7 2092
28
Tamsulosin Approved, Investigational Phase 2, Phase 3 106133-20-4 129211
29
Abatacept Approved Phase 3 332348-12-6 10237
30
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
31 Pharmaceutical Solutions Phase 3
32 Antirheumatic Agents Phase 3,Not Applicable
33 Calcineurin Inhibitors Phase 3
34 Immunosuppressive Agents Phase 3,Phase 2
35 Antifungal Agents Phase 3
36 Cyclosporins Phase 3
37 Immunologic Factors Phase 3,Phase 2,Phase 1
38 Dermatologic Agents Phase 3
39 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
40
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
41
Gemcitabine Approved Phase 2 95058-81-4 60750
42
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
43 Antimitotic Agents Phase 2
44 Antiviral Agents Phase 2
45 Antineoplastic Agents, Phytogenic Phase 2
46 Antimetabolites, Antineoplastic Phase 2
47 Albumin-Bound Paclitaxel Phase 2
48 Antimetabolites Phase 2
49 taxane Phase 2
50
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
2 Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones Completed NCT01533389 Phase 4 Silodosin;Placebo
3 Alfuzosin Treatment in Children and Adolescents With Hydronephrosis of Neuropathic Etiology Completed NCT00576823 Phase 3 Alfuzosin
4 Study to Evaluate the Efficacy and Safety of Tamsulosin in Children With Neurogenic Bladder Completed NCT00796614 Phase 2, Phase 3 tamsulosin hydrochloride;Placebo
5 Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression (BENEFIT) Completed NCT00256750 Phase 3 Cyclosporine (CsA);Belatacept LI (less intensive);Belatacept MI (more intensive)
6 Paclitaxel, Carboplatin and Gemcitabine in the Treatment of Patients With Advanced Transitional Cell Cancer of the Bladder Completed NCT00136175 Phase 2 Paclitaxel;Carboplatin;Gemcitabine
7 PK/PD, Long-term Safety and Efficacy of Tamsulosin Treatment in Children With Neurogenic Bladder Completed NCT00340704 Phase 2 tamsulosin hydrochloride
8 ODM-201 Maintenance Therapy in Patients With mCRPC Previously Treated With Novel Hormonal Agents. Recruiting NCT02933801 Phase 2 ODM-201
9 Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery Recruiting NCT02812420 Phase 1
10 Sonographic Follow up in Newborns Diagnosed With Prenatal Hydronephrosis Unknown status NCT01780103
11 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
12 Unilateral Cutaneous Ureterostomy - Long Term Follow up Unknown status NCT00546208
13 Initial Patient Evaluation in the Emergency Department With Point-of-Care Ultrasonography Unknown status NCT02099045
14 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431 Not Applicable
15 Keller Prehospital Ultrasound Study Unknown status NCT01074112
16 Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors Unknown status NCT02276924 Not Applicable
17 Hydronephrosis After Anterior Lumbar Interbody Fusion (ALIF) Completed NCT02976870 Not Applicable
18 Hydronephrosis on Ultrasound With CT Finding in Patients With Renal Colic Completed NCT01349244
19 Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis Completed NCT01839006
20 Simplified Diagnostic Algorithm for Evaluation of Neonates With Prenatally Detected Hydronephrosis Completed NCT01330511
21 Hydronephrosis ARFI Study Completed NCT01781845 Not Applicable
22 Emergency Department Targeted Ultrasound for the Detection of Hydronephrosis Completed NCT00555308 Not Applicable
23 Prospective Pediatric Pyeloplasty Robotic Surgical Database Completed NCT00882544
24 Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis Completed NCT00568724
25 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
26 Emergency Department Ultrasound in Renal Colic Completed NCT01323842
27 Influence of Transmission Season on Outcome of Treatment of Schistosoma Haematobium Infection in Mozambique Completed NCT00231322 Not Applicable praziquantel
28 Evaluating Ureteral Length Using Computed Tomography (CT) Completed NCT01542593 Not Applicable
29 Water Versus Saline as Irrigation Fluid for Ureteroscopy Completed NCT03794102 Not Applicable
30 Dismembered Pyeloplasty With and Without After Coming Stent Completed NCT02138877 Not Applicable
31 Sensitivity and Specificity of NGAL in an Emergency Room Population Completed NCT00786708
32 Infection Among Patients Undergoing Radical Cystectomy. Completed NCT03290742
33 Comparing Uretersocopy With Versus Without Use of Guide-wire in Treatment of Ureteral Stone Completed NCT03726502 Not Applicable
34 Study to Look for Artifact on Computed Tomography (CT) Representing Kidney Stones Completed NCT01187745
35 Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community Completed NCT00591968 Not Applicable
36 Effect of Double J Stent on Outcomes of Extracorporeal Shock Wave Lithotripsy Completed NCT03636516 Not Applicable
37 Sterile Single-use vs Reused Polyvinylchloride Catheter For Intermittent Catheterization In Neurogenic Bladder Completed NCT03424499 Not Applicable
38 The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine Completed NCT00930046 Not Applicable
39 Ureteral Stents Versus Percutaneous Nephrostomy for Initial Urinary Drainage Completed NCT02055430 Not Applicable
40 Stepwise Shock Wave Lithotripsy in Pediatric Urolithiasis Completed NCT01807260 Not Applicable
41 Minimizing the Utilization of Voiding Cystourethrography for Patients With Antenatal Hydronephrosis Recruiting NCT02825485 Not Applicable
42 Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction (LUTO) Recruiting NCT03281798 Not Applicable
43 Percutaneous Nephrostomy Versus Stent In Sepsis Trial Recruiting NCT02929160 Not Applicable
44 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
45 Point-of-care Ultrasound in Finland Recruiting NCT03327688 Not Applicable
46 Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Recruiting NCT03662906 Not Applicable
47 Randomized Trial of NSAID vs Placebo Prior to Ureteral Stent Removal Recruiting NCT02140970 Not Applicable Ibuprofen;Placebo
48 Sacral Nerve Stimulation in Improving Bladder After Acute Traumatic Spinal Cord Injury Recruiting NCT03083366 Not Applicable
49 Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis Active, not recruiting NCT01140516 Not Applicable Trimethoprim
50 Indwelling Stent Discoloration Project Active, not recruiting NCT02007980

Search NIH Clinical Center for Hydronephrosis

Cochrane evidence based reviews: hydronephrosis

Genetic Tests for Hydronephrosis

Genetic tests related to Hydronephrosis:

# Genetic test Affiliating Genes
1 Hydronephrosis 29

Anatomical Context for Hydronephrosis

MalaCards organs/tissues related to Hydronephrosis:

41
Kidney, Spinal Cord, Prostate, Skin, Lung, Uterus, Cervix

Publications for Hydronephrosis

Articles related to Hydronephrosis:

(show top 50) (show all 1190)
# Title Authors Year
1
High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis. ( 30431064 )
2019
2
Traumatic rupture of hydronephrosis secondary to UPJ obstruction in a child: A case report. ( 30534524 )
2019
3
Featuring: Comparative effectiveness of a pilot patient-centered ultrasound report in the management of hydronephrosis. ( 29793741 )
2018
4
Severe fetal hydronephrosis: the added value of associated congenital anomalies of the kidneys and urinary tract (CAKUT) in the prediction of postnatal outcome. ( 29314159 )
2018
5
Unexpected Hydronephrosis: Mesenteric Fibromatosis. ( 29730360 )
2018
6
Influence of postnatal hydroureter in determining the need for voiding cystourethrogram in children with high-grade hydronephrosis. ( 29892489 )
2018
7
99mTc-DTPA Diuretic Renography with 3 hours late output fraction in the evaluation of hydronephrosis in children. ( 29368879 )
2018
8
Prenatal Hydronephrosis-Another Swing of the Pendulum? ( 29777653 )
2018
9
Correction to: Postnatal imaging of prenatally detected hydronephrosis-when is voiding cystourethrogram necessary? ( 29948311 )
2018
10
Pyonephrosis as the first symptom of congenital hydronephrosis in a 6-year old girl. ( 29775448 )
2018
11
The association between continuous antibiotic prophylaxis and UTI from birth until initial postnatal imaging evaluation among newborns with antenatal hydronephrosis. ( 29891187 )
2018
12
N-acetylcysteine ameliorates contrasta89induced kidney injury in rats with unilateral hydronephrosis. ( 29207099 )
2018
13
A unique case of bilateral hydronephrosis caused by a fecalith. ( 29375869 )
2018
14
Predictive Analytics and Modeling Employing Machine Learning Technology: The Next Step in Data Sharing, Analysis and Individualized Counseling Explored with A Large, Prospective Prenatal Hydronephrosis Database. ( 29964127 )
2018
15
Total Colpectomy Increases the Risk of Postoperative Hydronephrosis in Vaginal Cancer Patients. ( 29469636 )
2018
16
Comparison of the F+20 and F-15 Diuresis Technetium-99m Diethylenetriaminepentacetate Renography Protocols for Diagnosis of Ureteropelvic Junction Obstruction in Adult Patients with Hydronephrosis. ( 29430113 )
2018
17
Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and I^-ENaC abundance in rat kidney. ( 29767556 )
2018
18
Bilateral simultaneous "Santosh Post-graduate Institute tubularized flap pyelovesicostomy" in a case of bilateral pelvi-ureteric junction obstruction with bilateral giant hydronephrosis. ( 29785556 )
2018
19
Delayed hydronephrosis due to retroperitoneal hematoma after a seatbelt injury: A case report. ( 29879068 )
2018
20
Neonatal Circumcision and Urinary Tract Infections in Infants With Hydronephrosis. ( 29880703 )
2018
21
Bilateral hydronephrosis and acute kidney injury secondary to pelvis lipomatosis. ( 29524979 )
2018
22
Semaphorin-3A and Netrin-1 predict the development of kidney injury in children with congenital hydronephrosis. ( 29199452 )
2018
23
Comparison Characteristics of Family and Demographic of Children with Antenatal Hydronephrosis between 2<sup>nd</sup>and 3<sup>rd</sup>Trimesters of Gestation. ( 29445638 )
2018
24
Safe discharge parameters for patients with isolated antenatal hydronephrosis. ( 29859769 )
2018
25
Diabetic Cystopathy with Bilateral Hydronephrosis. ( 29425706 )
2018
26
Ultrasound Markers in Fetal Hydronephrosis to Predict Postnatal Surgery. ( 29975970 )
2018
27
Isolated low grade prenatally detected unilateral hydronephrosis: do we need long term follow-up? ( 29757579 )
2018
28
Abdominal pain as a result of intermittent hydronephrosis. ( 29863257 )
2018
29
Diagnostic accuracy of Onen's Alternative Grading System combined with Doppler evaluation of ureteral jets as an alternative in the diagnosis of obstructive hydronephrosis in children. ( 29796345 )
2018
30
Diuretic renography in hydronephrosis: a retrospective single-center study. ( 29797216 )
2018
31
The urologist and child hydronephrosis caused by ureteral anomalies. ( 29940628 )
2018
32
Giant hydronephrosis presenting as acute pyelonephritis. ( 30418837 )
2018
33
How Prevalent is Hydronephrosis Secondary to Acute Appendicitis: A Cross-Sectional Study. ( 29527849 )
2018
34
Asymptomatic Lupus Cystitis with Bilateral Hydronephrosis. ( 30345278 )
2018
35
Acute mechanical duodenal obstruction due to giant hydronephrosis: an unusual cause of acute abdomen. ( 30344154 )
2018
36
Is the renal pyramidal thickness a good predictor for pyeloplasty in postnatal hydronephrosis? ( 29610048 )
2018
37
Postnatal imaging of prenatally detected hydronephrosis-when is voiding cystourethrogram necessary? ( 29626243 )
2018
38
The Correlation between Serial Ultrasound and Diuretic Renography in Children with Severe Unilateral Hydronephrosis. ( 29630977 )
2018
39
Parapelvic cysts mimicking hydronephrosis. ( 29636957 )
2018
40
Outcomes of Isolated Antenatal Hydronephrosis at First Year of Life. ( 29657681 )
2018
41
Emergency Physician Interpretation of Point-of-care Ultrasound for Identifying and Grading of Hydronephrosis in Renal Colic Compared With Consensus Interpretation by Emergency Radiologists. ( 29663580 )
2018
42
Re: Urinary Tract Infections in Children with Prenatal Hydronephrosis: A Risk Assessment from the Society for Fetal Urology Hydronephrosis Registry. ( 29677882 )
2018
43
Comparison of percutaneous nephrostomy and double J stent in symptomatic pregnancy hydronephrosis treatment ( 29714462 )
2018
44
Homemade ultrasound phantom for simulation of hydronephrosis. ( 29738039 )
2018
45
Gastrointestinal cancer and bilateral hydronephrosis resulted in a high risk of ureteral stent failure. ( 29739370 )
2018
46
Bilateral Giant Hydronephrosis in a Ten-Year-Old Male. ( 29850342 )
2018
47
Hydronephrosis and risk of later development of hypertension. ( 29959876 )
2018
48
Hydronephrosis due to a Migrated Intrauterine Device into the Ureter: A Very Rare Case. ( 30002585 )
2018
49
An Interesting Case of a 57-Year-Old Male with an Upper Gastrointestinal Bleeding and Obstructive Uropathy with Bilateral Hydronephrosis Diagnosed with Systemic Mucormycosis. ( 30026991 )
2018
50
A Dangerous Entrapment: Pelvic Aneurysms Causing Hydronephrosis. ( 30076821 )
2018

Variations for Hydronephrosis

ClinVar genetic disease variations for Hydronephrosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 C12orf57 NM_138425.3(C12orf57): c.53-2A> G single nucleotide variant Pathogenic rs1114167293 GRCh37 Chromosome 12, 7053637: 7053637
2 C12orf57 NM_138425.3(C12orf57): c.53-2A> G single nucleotide variant Pathogenic rs1114167293 GRCh38 Chromosome 12, 6944474: 6944474
3 SETBP1 NM_015559.2(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic GRCh38 Chromosome 18, 44951954: 44951954
4 SETBP1 NM_015559.2(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic GRCh37 Chromosome 18, 42531919: 42531919

Expression for Hydronephrosis

Search GEO for disease gene expression data for Hydronephrosis.

Pathways for Hydronephrosis

GO Terms for Hydronephrosis

Cellular components related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 ALB AQP2 B2M EGF MME NAGLU
2 platelet alpha granule lumen GO:0031093 8.92 ALB EGF TGFB1 TIMP1

Biological processes related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 middle ear morphogenesis GO:0042474 9.37 NAGLU OSR1
2 mammary gland alveolus development GO:0060749 9.32 EGF ID2
3 cell activation GO:0001775 9.26 TGFB1 TIMP1
4 locomotor rhythm GO:0045475 9.16 ID2 NAGLU
5 connective tissue replacement involved in inflammatory response wound healing GO:0002248 8.96 TGFB1 TIMP1
6 platelet degranulation GO:0002576 8.92 ALB EGF TGFB1 TIMP1

Molecular functions related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 ALB AQP2 B2M CCL2 DIS3L2 EGF

Sources for Hydronephrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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