Categories: Nephrological diseases

Aliases & Classifications for Hydronephrosis

Summaries for Hydronephrosis

MalaCards based summary : Hydronephrosis is related to congenital anomalies of kidney and urinary tract 2 and ureteral obstruction. An important gene associated with Hydronephrosis is WFS1 (Wolframin ER Transmembrane Glycoprotein), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Angiogenesis (CST). The drugs Midazolam and Propofol have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and spinal cord, and related phenotypes are no effect and mortality/aging

Wikipedia : 75 Hydronephrosis describes urine-filled dilation of the renal pelvis and/or calyces as a result of... more...

Related Diseases for Hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 518)
# Related Disease Score Top Affiliating Genes
1 congenital anomalies of kidney and urinary tract 2 34.3 TSHZ3 TGFB1 EGF
2 ureteral obstruction 31.4 TGFB1 SLC12A1 AQP2
3 pyelonephritis 31.3 NAGLU CCL2 ALB
4 obstructive nephropathy 31.0 TGFB1 EGF ALB
5 acute kidney failure 31.0 EGF B2M ALB
6 diabetes insipidus 30.9 WFS1 SLC12A1 AQP2
7 cystic kidney disease 30.9 EGF B2M ALB
8 peritonitis 30.5 CCL2 B2M ALB
9 glomerulonephritis 30.4 TGFB1 CCL2 ALB
10 urinary tract obstruction 30.3 TGFB1 NAGLU EGF CCL2 B2M AQP2
11 kidney disease 30.1 TGFB1 NAGLU CCL2 B2M AQP2 ALB
12 autosomal dominant polycystic kidney disease 29.6 EGF CCL2 AQP2 ALB
13 iga glomerulonephritis 29.6 TGFB1 NAGLU CCL2 ALB
14 membranous nephropathy 29.5 TGFB1 MME B2M ALB
15 liver cirrhosis 29.2 TIMP1 TGFB1 AQP2 ALB
16 hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation 12.6
17 coloboma porencephaly hydronephrosis 12.2
18 urofacial syndrome 1 12.1
19 visceral myopathy 11.7
20 ehlers-danlos syndrome, musculocontractural type, 1 11.7
21 cakut 11.6
22 musculocontractural ehlers-danlos syndrome 11.5
23 schinzel-giedion midface retraction syndrome 11.4
24 schinzel giedion syndrome 11.4
25 mesomelia-synostoses syndrome 11.4
26 carpenter syndrome 1 11.3
27 perlman syndrome 11.3
28 vacterl association, x-linked, with or without hydrocephalus 11.3
29 genitopatellar syndrome 11.3
30 urethral obstruction sequence 11.2
31 lacrimoauriculodentodigital syndrome 11.1
32 ritscher-schinzel syndrome 1 11.1
33 raine syndrome 11.1
34 otopalatodigital syndrome, type ii 11.1
35 kleefstra syndrome 11.1
36 desmoid tumor 11.1
37 potter's syndrome 11.1
38 al-gazali-donnai-mueller syndrome 11.1
39 split hand urinary anomalies spina bifida 11.1
40 vesicoureteral reflux 1 10.7
41 fibrosclerosis, multifocal 10.7
42 acute cystitis 10.7
43 immunodeficiency 43 10.5 B2M ALB
44 horseshoe kidney 10.5
45 acute kidney tubular necrosis 10.4 NAGLU B2M ALB
46 non-secretory myeloma 10.4 SETBP1 B2M ALB
47 bladder cancer 10.4
48 cystitis 10.4
49 orthostatic proteinuria 10.4 B2M ALB
50 posterior urethral valves 10.4

Comorbidity relations with Hydronephrosis via Phenotypic Disease Network (PDN): (show all 36)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bladder Cancer
Bladder Neck Obstruction Candidiasis
Cervical Cancer Colorectal Cancer
Cystitis Cystitis Cystica
Decubitus Ulcer Deficiency Anemia
Intestinal Obstruction Iron Deficiency Anemia
Kidney Disease Nephrolithiasis, Uric Acid
Nephrolithiasis, X-Linked Recessive, with Renal Failure Nephrosclerosis
Neurogenic Bladder Neutropenia
Ovarian Cancer Paralytic Ileus
Prostate Cancer Prostatic Hypertrophy
Protein-Energy Malnutrition Pyelonephritis
Radiation Cystitis Rectosigmoid Junction Neoplasm
Renal Pelvis Carcinoma Ureter, Cancer of
Ureterolithiasis Urethral Benign Neoplasm
Urethral Calculus Urethral Stricture
Urinary Tract Obstruction Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Hydronephrosis:

Diseases related to Hydronephrosis

Symptoms & Phenotypes for Hydronephrosis

GenomeRNAi Phenotypes related to Hydronephrosis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 AHR ALB AQP2 ATP5F1B B2M C12orf57

MGI Mouse Phenotypes related to Hydronephrosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.13 AHR ALB AQP2 ATP5F1B B2M C12orf57
2 immune system MP:0005387 10.07 AHR B2M CCL2 EGF ID2 MME
3 endocrine/exocrine gland MP:0005379 10.06 AHR ALB B2M EGF ID2 OSR1
4 integument MP:0010771 10.06 AHR AQP2 B2M EGF ID2 MME
5 digestive/alimentary MP:0005381 9.98 AHR ALB B2M EGF ID2 TGFB1
6 neoplasm MP:0002006 9.63 AHR ALB B2M ID2 TGFB1 TIMP1
7 renal/urinary system MP:0005367 9.61 AHR ALB AQP2 ID2 NAGLU OSR1
8 reproductive system MP:0005389 9.28 AHR AQP2 B2M EGF ID2 OSR1

Drugs & Therapeutics for Hydronephrosis

Drugs for Hydronephrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Etomidate Approved Phase 4 33125-97-2 36339 667484
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Silodosin Approved Phase 4 160970-54-7
tannic acid Approved Phase 4 1401-55-4
Allopurinol Approved Phase 4 315-30-0 2094
Sodium citrate Approved, Investigational Phase 4 68-04-2
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
Vancomycin Approved Phase 4 1404-90-6 441141 14969
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
Uric acid Investigational Phase 4 69-93-2 1175
19 Tranquilizing Agents Phase 4
20 Anti-Anxiety Agents Phase 4
21 Adjuvants, Anesthesia Phase 4
22 GABA Agents Phase 4
23 Hydrocortisone-17-butyrate Phase 4
24 Hypnotics and Sedatives Phase 4
25 Anesthetics, General Phase 4
26 GABA Modulators Phase 4
27 Psychotropic Drugs Phase 4
28 Anesthetics, Intravenous Phase 4
29 Hydrocortisone hemisuccinate Phase 4
30 Hydrocortisone 17-butyrate 21-propionate Phase 4
31 Anti-Bacterial Agents Phase 4
32 Antibiotics, Antitubercular Phase 4
33 Adrenergic alpha-1 Receptor Antagonists Phase 4
34 Adrenergic alpha-Antagonists Phase 4
35 Adrenergic Antagonists Phase 4
36 Adrenergic Agents Phase 4
37 Renal Agents Phase 4
38 Antitubercular Agents Phase 4
39 Anti-Infective Agents, Urinary Phase 4
40 Natriuretic Agents Phase 4
41 diuretics Phase 4
42 Antirheumatic Agents Phase 4
43 Citrate Phase 4
44 Free Radical Scavengers Phase 4
45 Respiratory System Agents Phase 4
46 Chelating Agents Phase 4
47 Antioxidants Phase 4
48 Protective Agents Phase 4
49 Expectorants Phase 4
50 Anticoagulants Phase 4

Interventional clinical trials:

(show top 50) (show all 96)
# Name Status NCT ID Phase Drugs
1 Phase 1 Study of Circadian Rhythm of Salivary Cortisol in Health Children ;Phase 2 Study of Circadian Rhythm of Salivary Cortisol of Children Undergoing Surgery Using Etomidate or Not Using Etomidate. Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
2 A 4-week, Double-blind, Randomized, Comparative and Multi-center Clinical Trial to Evaluate the Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones. Completed NCT01533389 Phase 4 Silodosin;Placebo
3 The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation Completed NCT02373384 Phase 4 Oral alkalinization (Potassium citrate, Allopurinol)
4 The EDGE Consortium: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Percutaneous Nephrolithotomy: Part 1 Completed NCT02384200 Phase 4 nitrofurantoin monohydrate/macrocrystalline capsules;ampicillin;gentamicin;vancomycin;ceftriaxone
5 Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy? Terminated NCT00334204 Phase 4
6 12-week, Multicenter, Open-label, Non-comparative Study to Investigate Pharmacodynamic and Safety of Alfuzosin 0.2 mg/kg/Day in the Treatment of Children and Adolescents 2 - 16 Years of Age With Hydronephrosis Associated With Elevated Detrusor Leak Point Pressure of Neuropathic Etiology Followed by a 40-week Open-label Extension Completed NCT00576823 Phase 3 Alfuzosin
7 Randomized Phase III Study of 5-FU Continuous Infusion (5FUci) Versus MTX+5-FU Sequential Therapy (MF) in Gastric Cancer With Peritoneal Metastasis (JCOG0106-MF, MF/5FU) Completed NCT00149201 Phase 3 5-FU continuous infusion;MTX + 5-FU sequential therapy
8 Randomized Controlled Trial of Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Unknown status NCT01552824 Phase 2
9 A Phase II Clinical Trial to Evaluate the Potential of Concomitant Chemoradiotherapy With Gemcitabine in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease Recruiting NCT03101995 Phase 2 Gemcitabine
10 Botulinum Toxin A Treatment of Detrusor External Sphincter Dyssynergia During Early Spinal Cord Injury (Protocol #H-20344) Terminated NCT00711087 Phase 2 BOTOX-A
11 A Pilot Pre-Surgical Study Evaluating Anti-PD-L1 Antibody (Durvalumab) Plus Anti-CTLA-4 (Tremelimumab) in Patients With Muscle-Invasive, High-Risk Urothelial Carcinoma Who Are Ineligible for Cisplatin-Based Neoadjuvant Chemotherapy Recruiting NCT02812420 Phase 1
12 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
13 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance in Children With Scintigraphically Prooved Obstruction. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431
14 Bladder Function Following Temporary Unilateral Cutaneous Ureterostomy - Long Term Follow up Unknown status NCT00546208
15 Sonographic Follow up in Newborns Diagnosed With Prenatal Hydronephrosis Unknown status NCT01780103
16 Part 1 The Outcome of Children With Melamine-Related-Calculus Unknown status NCT00895765
17 Conventional Antibiotic Prophylaxis Versus Add-On 5 Days Levofloxacin Before Percutaneous Nephrolithotomy (PCNL) Unknown status NCT03178292 Levofloxacin;Placebo
18 The Use of Tamsulosin in Treatment of (10-15 mm) Lower Ureteric Stones in Adults With Non-emergent Symptoms: A Prospective Randomized Study Unknown status NCT03274700 Early Phase 1 Tamsulosin.;Placebo.
19 Assessment of Flexible Ureteroscopy Residual Fragments Unknown status NCT02434068
20 Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery: a Prospective Randomized Trail in Comparison of Multiple-, Single- and Zero-dose. Unknown status NCT02304822 Multiple-dose of Ciprofloxacin prophylaxis;Single-dose of Ciprofloxacin prophylaxis;Zero-dose of Ciprofloxacin prophylaxis
21 Keller Fire Rescue Study of Prehospital Ultrasound Use Unknown status NCT01074112
22 Prevalence of Pediatric Urolithiasis in Kashgar Area of Xinjiang in China: a Population and Ultrasonography Based Cross-sectional Study Unknown status NCT03003312
23 Correlation of Hydronephrosis on Point of Care Ultrasound With CT Finding in Patients With Expected Renal Colic Completed NCT01349244
24 Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis Completed NCT00568724
25 Hydronephrosis After Anterior Lumbar Interbody Fusion (ALIF) Completed NCT02976870
26 Simplified Diagnostic Algorithm for Evaluation of Neonates With Prenatally Detected Hydronephrosis Completed NCT01330511
27 Emergency Department Targeted Ultrasound for the Detection of Hydronephrosis Completed NCT00555308
28 Evaluation of Ultrasound Acoustic Radiation Force Impulse (ARFI)Shear Wave Velocity Imaging (SVI)in the Characterization of Pediatric Hydronephrosis Completed NCT01781845
29 Hydro II: Emergency Department Ultrasound in Renal Colic Completed NCT01323842
30 Clinical Significance of Supranormal Differential Renal Function in the Recovery of Unilateral Hydronephrosis After Surgery: Long-term Results Completed NCT01839006
31 Bedside Ultrasonography in Acute Patients With Suspected Kidney Involvement Completed NCT03873701
32 Dismembered Pyeloplasty With and Without After Coming Stent in Neonatal Ureteropelvic Junction Obstruction Completed NCT02138877
33 Sensitivity and Specificity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in an Emergency Room Population Completed NCT00786708
34 Incidence of and Risk Factors for Perioperative Infection Among Patients Undergoing Radical Cystectomy Completed NCT03290742
35 Evaluation of Ureteral Length Measurement by Computed Tomography (CT) to Actual Ureteral Length Measured by Ureteral Catheterization Completed NCT01542593
36 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
37 The Effects of Water Versus Saline on Absorption Rates and Visualization During Ureteroscopy Completed NCT03794102
38 Diagnostic Relevance of Laser Confocal Microscopy During Reno-ureteroscopy in the Context of the Screening and Follow-up of Upper Urinary Tract Tumors Completed NCT02276924
39 Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children Completed NCT00528476
40 Acute Kidney Injury in Premature Infants Completed NCT00573079
41 Prospective Pediatric Pyeloplasty Robotic Surgical Database Completed NCT00882544
42 Comparative Study of Extracorporeal Shock Wave Lithotripsy and Ureteroscopy in Management of Upper Third Ureteral Calculi Completed NCT03559738
43 The Influence of Transmission Season on Outcome of Schistosoma Haematobium Infection Treatment Among School Children in Urban and Peri-Urban Areas of Maputo and Matola, Mozambique Completed NCT00231322 praziquantel
44 Post Approval Study: MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270
45 Effect of Double J Stent on Outcomes of Extracorporeal Shock Wave Lithotripsy Treatment of Moderate Sized Renal Pelvic Stones: A Randomized Prospective Study Completed NCT03636516
46 Standardized Skin Care Regimen in the Diaper Area: a Prospective, Randomized Clinical Study on Skin Barrier Function and Epidermal IL-1α Completed NCT01131403
47 Feasibility and Impact of a Decision Rule for Imaging of Emergency Department Patients With Suspected Kidney Stone Completed NCT01869647
48 Post Approval Study: MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00131365
49 Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community Completed NCT00591968
50 Accuracy of Surgeon-performed Ultrasound in Detecting Gallstones - a Validation Study Completed NCT02469935

Search NIH Clinical Center for Hydronephrosis

Cochrane evidence based reviews: hydronephrosis

Genetic Tests for Hydronephrosis

Genetic tests related to Hydronephrosis:

# Genetic test Affiliating Genes
1 Hydronephrosis 29

Anatomical Context for Hydronephrosis

MalaCards organs/tissues related to Hydronephrosis:

Kidney, Prostate, Spinal Cord, Colon, Cervix, Bone, Breast

Publications for Hydronephrosis

Articles related to Hydronephrosis:

(show top 50) (show all 10715)
# Title Authors PMID Year
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. 9 38
11137441 2001
In fetuses with isolated hydronephrosis, urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) have a limited role in the prediction of postnatal renal function. 9 38
8994243 1996
Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo. 9 38
8589437 1995
[Evaluation of renal function and prediction of renal functional recovery in children with unilateral hydronephrosis using renal pelvic urine]. 9 38
1282579 1992
Rare case of an upper urinary tract carcinoma (UTUC) in renal pelvis and ureter associated to renal vein thrombosis: diagnostic imaging with CECT, MRI and CEUS. 38
31243704 2019
Urinothorax causing massive left side pleural effusion in a young lady; case report and literature review. 38
31321210 2019
Analysis of factors affecting radiation exposure during percutaneous nephrolithotomy procedures. 38
31140706 2019
Vaginal reconstruction for distal vaginal atresia without anorectal malformation: is the approach different? 38
31256298 2019
Isolated antenatal hydronephrosis with renal pelvis antero-posterior diameter ≤ 20 mm. 38
31300883 2019
Long term follow-up in a patient with prune-belly syndrome - a care compliant case report. 38
31415370 2019
[Organ preservation by chemoradiation for bladder cancer]. 38
31400955 2019
A risk-stratified approach to neoadjuvant chemotherapy in muscle-invasive bladder cancer: implications for patients classified with low-risk disease. 38
30392012 2019
Formula for predicting the impaction of ureteral stones. 38
31378836 2019
Predicting the Impacted Ureteral Stone with Computed Tomography. 38
31029671 2019
A case of allograft ureteral stone successfully treated with antegrade ureteroscopic lithotripsy: use of a 3D-printed model to determine the ideal approach. 38
31399789 2019
Laparoscopy versus robotic-assisted pyeloplasty in children: preliminary results of a pilot prospective randomized controlled trial. 38
31435732 2019
[Treatment of crossing vessels in laparoscopic pyeloplasty]. 38
31420618 2019
Laparoscopic Approach in Management of Renal Cell Carcinoma During Pregnancy: State of the Art. 38
31227431 2019
Point-of-Care Ultrasound for the Pediatric Hospitalist's Practice. 38
31405888 2019
Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation. 38
31408229 2019
The effect of using ureteral access sheath for treatment of impacted ureteral stones at mid-upper part with flexible ureterorenoscopy: a randomized prospective study. 38
31144488 2019
Diagnosis of an Acute Lobar Nephronia in the Emergency Department Using POINT-OF-CARE Ultrasound. 38
31262548 2019
Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma. 38
31378586 2019
Primary carcinosarcoma of the ureteropelvic junction associated with ureteral duplication: A case report. 38
31393362 2019
Predictors of spontaneous ureteral stone passage in the presence of an indwelling ureteral stent. 38
30349974 2019
What factors drive staghorn versus non-staghorn pattern growth in patients with metabolic stones? 38
31436119 2019
Why Does Prevention of Recurrent Urinary Tract Infection not Result in Less Renal Scarring? A Deeper Dive into the RIVUR Trial. 38
31026216 2019
Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine. 38
31300484 2019
Surgical resection based on ontogenetic cancer field theory for cervical cancer: mature results from a single-centre, prospective, observational, cohort study. 38
31383547 2019
Total Colpectomy Increases the Risk of Postoperative Hydronephrosis in Vaginal Cancer Patients. 38
29469636 2019
The Prevalence, Clinicodemographics, and Outcomes of Incidental and Symptomatic Renal Cysts in a Pediatric Cohort Undergoing Ultrasonography. 38
30958740 2019
Right hydronephrosis secondary to fecal impaction. 38
30771998 2019
[Application of machine learning models in predicting early stone-free rate after flexible ureteroscopic lithotripsy for renal stones]. 38
31420617 2019
Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis. 38
31324419 2019
Ultrasound evaluation for prediction of outcomes and surgical decision in fetal hydronephrosis. 38
31316627 2019
Preoperative predictors of early death risk in bladder cancer patients treated with robot-assisted radical cystectomy. 38
31091022 2019
Endovascular Repair of Inflammatory Aortic Aneurysms: Experience in a Single Center. 38
30735769 2019
Lupus intestinal pseudo-obstruction and hydronephrosis: Case report. 38
31305400 2019
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis. 38
31115520 2019
Mini-invasive robotic assisted pyelolithotomy: Comparison between the transperitoneal and retroperitoneal approach. 38
31266278 2019
Laparoscopic Extravesical Ureteral Reimplantation for Correction of Primary and Secondary Megaureters: Preliminary Report of a New Simplified Technique. 38
31326110 2019
Bowel Excretion of Technetium-99mL, L-Ethylene Dicysteine Masquerading as a Dilated Ureter in a Case of Pelvi-Ureteric Junction Obstruction: Case Report and Review. 38
31258277 2019
The visual percutaneous nephrolithotomy versus the conventional percutaneous nephrolithotomy in treatment for renal stone. 38
31287255 2019
Radiographic abnormalities, bladder interventions, and bladder surgery in the first decade of life in children with spina bifida. 38
30826869 2019
Renal failure caused by severe pelvic organ prolapse. 38
31315842 2019
Antenatally detected ureterocele: Associated anomalies and postnatal prognosis. 38
31307746 2019
Impact of de novo vesicoureteral reflux on transurethral surgery outcomes in pediatric patients with ureteroceles. 38
31294139 2019
Minilaparoscopic Versus Open Pyeloplasty in Children Less Than 1 Year. 38
31211649 2019
Modified posterior pelvic exenteration with pelvic side-wall resection requiring both intestinal and urinary reconstruction during surgery for ovarian cancer. 38
31351675 2019
Of Mice and Men-The Physiology, Psychology, and Pathology of Overhydration. 38
31284689 2019

Variations for Hydronephrosis

ClinVar genetic disease variations for Hydronephrosis:

6 (show all 11)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 C12orf57 NM_138425.4(C12orf57): c.53-2A> G single nucleotide variant Pathogenic rs1114167293 12:7053637-7053637 12:6944474-6944474
2 46;XY;inv(6)(p22q13)dn inversion Pathogenic
3 WFS1 NM_006005.3(WFS1): c.1999C> T (p.Gln667Ter) single nucleotide variant Pathogenic 4:6303521-6303521 4:6301794-6301794
4 CHN1 NM_001822.5(CHN1): c.667G> A (p.Ala223Thr) single nucleotide variant Likely pathogenic 2:175689207-175689207 2:174824479-174824479
5 SETBP1 NM_015559.3(SETBP1): c.2614G> A (p.Gly872Arg) single nucleotide variant Likely pathogenic rs1555706928 18:42531919-42531919 18:44951954-44951954
6 KIF1A NM_004321.7(KIF1A): c.2749C> T (p.His917Tyr) single nucleotide variant Uncertain significance 2:241686664-241686664 2:240747247-240747247
7 XDH NM_000379.4(XDH): c.1172C> T (p.Pro391Leu) single nucleotide variant Uncertain significance 2:31602803-31602803 2:31379937-31379937
8 XDH NM_000379.4(XDH): c.3647C> A (p.Pro1216His) single nucleotide variant Uncertain significance rs143981573 2:31562482-31562482 2:31339616-31339616
9 GATA4 NM_002052.5(GATA4): c.94G> C (p.Ala32Pro) single nucleotide variant Uncertain significance 8:11565915-11565915 8:11708406-11708406
10 ERF NM_006494.4(ERF): c.1636C> T (p.Arg546Ter) single nucleotide variant Uncertain significance 19:42752628-42752628 19:42248476-42248476
11 FLNA NM_001110556.2(FLNA): c.3934C> T (p.Arg1312Cys) single nucleotide variant Uncertain significance X:153588145-153588145 X:154359777-154359777

Expression for Hydronephrosis

Search GEO for disease gene expression data for Hydronephrosis.

Pathways for Hydronephrosis

Pathways related to Hydronephrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 TIMP1 TGFB1 CCL2
2 11.28 TIMP1 TGFB1 CCL2
3 11 TGFB1 MME ID2
4 10.72 TIMP1 TGFB1 EGF CCL2
5 10.6 TIMP1 CCL2

GO Terms for Hydronephrosis

Cellular components related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 TIMP1 SLC12A1 NAGLU MME EGF B2M
2 endoplasmic reticulum lumen GO:0005788 9.46 WFS1 TIMP1 B2M ALB
3 platelet alpha granule lumen GO:0031093 8.92 TIMP1 TGFB1 EGF ALB

Biological processes related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.46 WFS1 TIMP1 B2M ALB
2 middle ear morphogenesis GO:0042474 9.43 OSR1 NAGLU
3 mammary gland alveolus development GO:0060749 9.4 ID2 EGF
4 negative regulation of programmed cell death GO:0043069 9.37 WFS1 ALB
5 cell activation GO:0001775 9.32 TIMP1 TGFB1
6 locomotor rhythm GO:0045475 9.26 NAGLU ID2
7 connective tissue replacement involved in inflammatory response wound healing GO:0002248 8.96 TIMP1 TGFB1
8 platelet degranulation GO:0002576 8.92 TIMP1 TGFB1 EGF ALB

Molecular functions related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 WFS1 TSHZ3 TIMP1 TGFB1 SETBP1 MME

Sources for Hydronephrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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