MCID: HYD002
MIFTS: 59

Hydronephrosis

Categories: Nephrological diseases

Aliases & Classifications for Hydronephrosis

Summaries for Hydronephrosis

MalaCards based summary : Hydronephrosis is related to vesicoureteral reflux 1 and ureteral obstruction. An important gene associated with Hydronephrosis is WFS1 (Wolframin ER Transmembrane Glycoprotein), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Interleukin-4 and 13 signaling. The drugs Propofol and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and spinal cord, and related phenotypes are behavior/neurological and cellular

Wikipedia : 74 Hydronephrosis describes urine-filled dilation of the renal pelvis and/or calyces as a result of... more...

Related Diseases for Hydronephrosis

Diseases related to Hydronephrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 642)
# Related Disease Score Top Affiliating Genes
1 vesicoureteral reflux 1 32.0 TGFB1 NAGLU C12orf57 B2M ALB
2 ureteral obstruction 32.0 TGFB1 SLC12A1 AQP2
3 acute cystitis 31.9 IL6 CCL2 ALB
4 urinary tract obstruction 31.8 TGFB1 NAGLU EGF CCL2 B2M AQP2
5 pyelonephritis 31.8 NAGLU IL6 CCL2 AQP2 ALB
6 diabetes insipidus 31.5 WFS1 SLC12A1 AQP2
7 obstructive nephropathy 31.5 TGFB1 EGF CCL2 ALB
8 cystitis 31.5 VEGFA IL6 EGF CCL2
9 acute kidney failure 31.4 EGF B2M ALB
10 acute pyelonephritis 31.3 NAGLU IL6 ALB
11 posterior urethral valves 31.3 TGFB1 IL6
12 appendicitis 31.3 IL6 CCL2 ALB
13 cystic kidney disease 31.3 EGF B2M AQP2 ALB
14 nephrolithiasis, calcium oxalate 31.2 SLC12A1 NAGLU CCL2 AQP2 ALB
15 pyelitis 31.1 IL6 B2M ALB
16 peritonitis 31.1 IL6 CCL2 B2M ALB
17 pyuria 31.0 IL6 B2M ALB
18 glomerulonephritis 30.9 TGFB1 CCL2 B2M ALB
19 xanthogranulomatous pyelonephritis 30.9 EGF CCL2
20 kidney disease 30.9 VEGFA TGFB1 SLC12A1 NAGLU IL6 CCL2
21 intussusception 30.8 VEGFA IL6 ALB
22 intestinal obstruction 30.8 IL6 FLNA ALB
23 chronic kidney disease 30.8 VEGFA TGFB1 IL6 CCL2 B2M AQP2
24 nephrosclerosis 30.8 VEGFA TGFB1 CCL2
25 diarrhea 30.8 TGFB1 MME IL6 FLNA ALB
26 interstitial cystitis 30.7 VEGFA IL6 EGF
27 ureteral disease 30.7 TGFB1 IL6 CCL2 AQP2 ALB
28 diabetes mellitus 30.7 WFS1 VEGFA TGFB1 NAGLU IL6 CCL2
29 uremia 30.6 IL6 B2M ALB
30 protein-losing enteropathy 30.5 ZIC3 VEGFA ALB
31 intestinal pseudo-obstruction 30.5 FLNA B2M ALB
32 fanconi syndrome 30.5 NAGLU B2M ALB
33 congestive heart failure 30.5 VEGFA MME IL6 AQP2 ALB
34 varicose veins 30.5 VEGFA IL6 CCL2
35 polycystic kidney disease 30.5 VEGFA EGF AQP2 ALB
36 gastric ulcer 30.5 VEGFA IL6 EGF
37 exanthem 30.4 VEGFA IL6 ALB
38 membranous nephropathy 30.4 MME B2M ALB
39 suppression of tumorigenicity 12 30.4 VEGFA IL6 EGF ALB
40 mucositis 30.4 VEGFA TGFB1 EGF
41 peripheral artery disease 30.4 VEGFA IL6 CCL2
42 chorioamnionitis 30.4 VEGFA IL6 CCL2
43 bone inflammation disease 30.4 VEGFA IL6 CCL2 ALB
44 schistosomiasis 30.3 TGFB1 CCL2 ALB
45 diffuse large b-cell lymphoma 30.3 VEGFA MME IL6 B2M
46 plasmacytoma 30.3 VEGFA IL6 B2M
47 vascular disease 30.2 VEGFA TGFB1 IL6 CCL2 ALB
48 autosomal dominant polycystic kidney disease 30.2 VEGFA TGFB1 EGF CCL2 AQP2 ALB
49 osteoporosis 30.1 VEGFA TGFB1 IL6 EGF CCL2 B2M
50 arthritis 30.0 VEGFA TGFB1 IL6 CCL2 ALB

Comorbidity relations with Hydronephrosis via Phenotypic Disease Network (PDN): (show all 36)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Bladder Cancer
Bladder Neck Obstruction Candidiasis
Cervical Cancer Colorectal Cancer
Cystitis Cystitis Cystica
Decubitus Ulcer Deficiency Anemia
Intestinal Obstruction Iron Deficiency Anemia
Kidney Disease Nephrolithiasis, Uric Acid
Nephrolithiasis, X-Linked Recessive, with Renal Failure Nephrosclerosis
Neurogenic Bladder Neutropenia
Ovarian Cancer Paralytic Ileus
Prostate Cancer Prostatic Hypertrophy
Protein-Energy Malnutrition Pyelonephritis
Radiation Cystitis Rectosigmoid Junction Neoplasm
Renal Pelvis Carcinoma Ureter, Cancer of
Ureterolithiasis Urethral Benign Neoplasm
Urethral Calculus Urethral Stricture
Urinary Tract Obstruction Vesicoureteral Reflux 1

Graphical network of the top 20 diseases related to Hydronephrosis:



Diseases related to Hydronephrosis

Symptoms & Phenotypes for Hydronephrosis

MGI Mouse Phenotypes related to Hydronephrosis:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.35 AQP2 FLNA ID2 IL6 MME NAGLU
2 cellular MP:0005384 10.29 ALB B2M FLNA ID2 IL6 MME
3 homeostasis/metabolism MP:0005376 10.28 ALB AQP2 B2M C12orf57 FLNA IL6
4 growth/size/body region MP:0005378 10.27 AQP2 B2M EGF FLNA ID2 IL6
5 cardiovascular system MP:0005385 10.26 ALB B2M FLNA IL6 NAGLU OSR1
6 immune system MP:0005387 10.22 ALB B2M CCL2 EGF FLNA ID2
7 digestive/alimentary MP:0005381 10.19 ALB B2M EGF FLNA ID2 IL6
8 mortality/aging MP:0010768 10.19 ALB AQP2 B2M C12orf57 FLNA ID2
9 integument MP:0010771 10.15 AQP2 B2M EGF ID2 IL6 MME
10 endocrine/exocrine gland MP:0005379 10.13 ALB B2M EGF ID2 IL6 OSR1
11 liver/biliary system MP:0005370 9.97 ALB B2M FLNA IL6 MME NAGLU
12 nervous system MP:0003631 9.9 B2M FLNA ID2 IL6 MME NAGLU
13 renal/urinary system MP:0005367 9.65 ALB AQP2 ID2 IL6 NAGLU OSR1
14 reproductive system MP:0005389 9.36 AQP2 B2M EGF FLNA ID2 IL6

Drugs & Therapeutics for Hydronephrosis

Drugs for Hydronephrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
5
Etomidate Approved Phase 4 33125-97-2 36339 667484
6
Silodosin Approved Phase 4 160970-54-7
7
Allopurinol Approved Phase 4 315-30-0 2094
8
tannic acid Approved Phase 4 1401-55-4
9
Potassium citrate Approved, Investigational, Vet_approved Phase 4
10
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
11
Sodium citrate Approved, Investigational Phase 4 68-04-2
12
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
13
Vancomycin Approved Phase 4 1404-90-6 441141 14969
14
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
15
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
16
Uric acid Investigational Phase 4 69-93-2 1175
17 Tranquilizing Agents Phase 4
18 Anti-Anxiety Agents Phase 4
19 Hydrocortisone hemisuccinate Phase 4
20 Hypnotics and Sedatives Phase 4
21 Hydrocortisone 17-butyrate 21-propionate Phase 4
22 Hydrocortisone-17-butyrate Phase 4
23 Adjuvants, Anesthesia Phase 4
24 GABA Agents Phase 4
25 Anesthetics, General Phase 4
26 Anesthetics, Intravenous Phase 4
27 GABA Modulators Phase 4
28 Psychotropic Drugs Phase 4
29 Adrenergic Antagonists Phase 4
30 Adrenergic alpha-Antagonists Phase 4
31 Adrenergic Agents Phase 4
32 Natriuretic Agents Phase 4
33 diuretics Phase 4
34 Antirheumatic Agents Phase 4
35 Citrate Phase 4
36 Chelating Agents Phase 4
37 Anticoagulants Phase 4
38 Free Radical Scavengers Phase 4
39 Antioxidants Phase 4
40 Respiratory System Agents Phase 4
41 Protective Agents Phase 4
42 Calcium, Dietary Phase 4
43 Expectorants Phase 4
44 penicillins Phase 4
45
Alfuzosin Approved, Investigational Phase 3 81403-80-7 2092
46
Fluorouracil Approved Phase 3 51-21-8 3385
47 Pharmaceutical Solutions Phase 3
48
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
49
Pancuronium Approved Phase 2 16974-53-1, 15500-66-0 27350 441289
50
Gemcitabine Approved Phase 2 95058-81-4 60750

Interventional clinical trials:

(show top 50) (show all 98)
# Name Status NCT ID Phase Drugs
1 Phase 1 Study of Circadian Rhythm of Salivary Cortisol in Health Children ;Phase 2 Study of Circadian Rhythm of Salivary Cortisol of Children Undergoing Surgery Using Etomidate or Not Using Etomidate. Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
2 A 4-week, Double-blind, Randomized, Comparative and Multi-center Clinical Trial to Evaluate the Efficacy and Safety of Silodosin in the Treatment of Natural Expulsion in Patients With Ureteral Stones. Completed NCT01533389 Phase 4 Silodosin;Placebo
3 The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation Completed NCT02373384 Phase 4 Oral alkalinization (Potassium citrate, Allopurinol)
4 The EDGE Consortium: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Percutaneous Nephrolithotomy: Part 1 Completed NCT02384200 Phase 4 nitrofurantoin monohydrate/macrocrystalline capsules;ampicillin;gentamicin;vancomycin;ceftriaxone
5 Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy? Terminated NCT00334204 Phase 4
6 12-week, Multicenter, Open-label, Non-comparative Study to Investigate Pharmacodynamic and Safety of Alfuzosin 0.2 mg/kg/Day in the Treatment of Children and Adolescents 2 - 16 Years of Age With Hydronephrosis Associated With Elevated Detrusor Leak Point Pressure of Neuropathic Etiology Followed by a 40-week Open-label Extension Completed NCT00576823 Phase 3 Alfuzosin
7 Randomized Phase III Study of 5-FU Continuous Infusion (5FUci) Versus MTX+5-FU Sequential Therapy (MF) in Gastric Cancer With Peritoneal Metastasis (JCOG0106-MF, MF/5FU) Completed NCT00149201 Phase 3 5-FU continuous infusion;MTX + 5-FU sequential therapy
8 Randomized Controlled Trial of Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Unknown status NCT01552824 Phase 2
9 A Phase II Clinical Trial to Evaluate the Potential of Concomitant Chemoradiotherapy With Gemcitabine in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease Recruiting NCT03101995 Phase 2 Gemcitabine
10 Botulinum Toxin A Treatment of Detrusor External Sphincter Dyssynergia During Early Spinal Cord Injury (Protocol #H-20344) Terminated NCT00711087 Phase 2 BOTOX-A
11 The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients Unknown status NCT01711996
12 Bladder Function Following Temporary Unilateral Cutaneous Ureterostomy - Long Term Follow up Unknown status NCT00546208
13 Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance in Children With Scintigraphically Prooved Obstruction. A Prospective, Randomized, Controlled Multi-Center Study Unknown status NCT00444431
14 Sonographic Follow up in Newborns Diagnosed With Prenatal Hydronephrosis Unknown status NCT01780103
15 Part 1 The Outcome of Children With Melamine-Related-Calculus Unknown status NCT00895765
16 Ureteral Reimplantation for the Treatment of Extrinsic Malignant Ureteral Obstruction Unknown status NCT02160652
17 Conventional Antibiotic Prophylaxis Versus Add-On 5 Days Levofloxacin Before Percutaneous Nephrolithotomy (PCNL) Unknown status NCT03178292 Levofloxacin;Placebo
18 Prospective Evaluation of Patients With Uterine Cervical Cancer in Brazilian Health Institutions - The EVITA I Study Unknown status NCT02671071
19 The Use of Tamsulosin in Treatment of (10-15 mm) Lower Ureteric Stones in Adults With Non-emergent Symptoms: A Prospective Randomized Study Unknown status NCT03274700 Early Phase 1 Tamsulosin.;Placebo.
20 Ciprofloxacin Prophylaxis in Retrograde Intrarenal Surgery: a Prospective Randomized Trail in Comparison of Multiple-, Single- and Zero-dose. Unknown status NCT02304822 Multiple-dose of Ciprofloxacin prophylaxis;Single-dose of Ciprofloxacin prophylaxis;Zero-dose of Ciprofloxacin prophylaxis
21 Assessment of Flexible Ureteroscopy Residual Fragments Unknown status NCT02434068
22 Keller Fire Rescue Study of Prehospital Ultrasound Use Unknown status NCT01074112
23 Prevalence of Pediatric Urolithiasis in Kashgar Area of Xinjiang in China: a Population and Ultrasonography Based Cross-sectional Study Unknown status NCT03003312
24 Correlation of Hydronephrosis on Point of Care Ultrasound With CT Finding in Patients With Expected Renal Colic Completed NCT01349244
25 Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis Completed NCT00568724
26 Hydronephrosis After Anterior Lumbar Interbody Fusion (ALIF) Completed NCT02976870
27 Simplified Diagnostic Algorithm for Evaluation of Neonates With Prenatally Detected Hydronephrosis Completed NCT01330511
28 Emergency Department Targeted Ultrasound for the Detection of Hydronephrosis Completed NCT00555308
29 Evaluation of Ultrasound Acoustic Radiation Force Impulse (ARFI)Shear Wave Velocity Imaging (SVI)in the Characterization of Pediatric Hydronephrosis Completed NCT01781845
30 Hydro II: Emergency Department Ultrasound in Renal Colic Completed NCT01323842
31 Clinical Significance of Supranormal Differential Renal Function in the Recovery of Unilateral Hydronephrosis After Surgery: Long-term Results Completed NCT01839006
32 Sensitivity and Specificity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in an Emergency Room Population Completed NCT00786708
33 Bedside Ultrasonography in Acute Patients With Suspected Kidney Involvement Completed NCT03873701
34 Dismembered Pyeloplasty With and Without After Coming Stent in Neonatal Ureteropelvic Junction Obstruction Completed NCT02138877
35 Evaluation of Ureteral Length Measurement by Computed Tomography (CT) to Actual Ureteral Length Measured by Ureteral Catheterization Completed NCT01542593
36 Incidence of and Risk Factors for Perioperative Infection Among Patients Undergoing Radical Cystectomy Completed NCT03290742
37 Use of the PercSys MicroStent Device to Alleviate Ureteral Stone Symptoms and Hydronephrosis Completed NCT01637519
38 Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children Completed NCT00528476
39 The Effects of Water Versus Saline on Absorption Rates and Visualization During Ureteroscopy Completed NCT03794102
40 Acute Kidney Injury in Premature Infants Completed NCT00573079
41 Prospective Pediatric Pyeloplasty Robotic Surgical Database Completed NCT00882544
42 Comparative Study of Extracorporeal Shock Wave Lithotripsy and Ureteroscopy in Management of Upper Third Ureteral Calculi Completed NCT03559738
43 Post Approval Study: MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00166270
44 The Influence of Transmission Season on Outcome of Schistosoma Haematobium Infection Treatment Among School Children in Urban and Peri-Urban Areas of Maputo and Matola, Mozambique Completed NCT00231322 praziquantel
45 Effect of Double J Stent on Outcomes of Extracorporeal Shock Wave Lithotripsy Treatment of Moderate Sized Renal Pelvic Stones: A Randomized Prospective Study Completed NCT03636516
46 Feasibility and Impact of a Decision Rule for Imaging of Emergency Department Patients With Suspected Kidney Stone Completed NCT01869647
47 Studying the Dose Response of 50 and 100 IU of Botox A Toxin Injection in the Prostates of BPH Patients. Completed NCT02524236 Early Phase 1 Botox injection in the prostate
48 Post Approval Study: MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids Completed NCT00131365
49 Accuracy of Surgeon-performed Ultrasound in Detecting Gallstones - a Validation Study Completed NCT02469935
50 Standardized Skin Care Regimen in the Diaper Area: a Prospective, Randomized Clinical Study on Skin Barrier Function and Epidermal IL-1α Completed NCT01131403

Search NIH Clinical Center for Hydronephrosis

Cochrane evidence based reviews: hydronephrosis

Genetic Tests for Hydronephrosis

Genetic tests related to Hydronephrosis:

# Genetic test Affiliating Genes
1 Hydronephrosis 29

Anatomical Context for Hydronephrosis

MalaCards organs/tissues related to Hydronephrosis:

40
Kidney, Prostate, Spinal Cord, Bone, Colon, Cervix, Breast

Publications for Hydronephrosis

Articles related to Hydronephrosis:

(show top 50) (show all 10896)
# Title Authors PMID Year
1
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. 54 61
11137441 2001
2
In fetuses with isolated hydronephrosis, urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) have a limited role in the prediction of postnatal renal function. 54 61
8994243 1996
3
Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo. 54 61
8589437 1995
4
[Evaluation of renal function and prediction of renal functional recovery in children with unilateral hydronephrosis using renal pelvic urine]. 54 61
1282579 1992
5
Bladder preservation in muscle-invasive bladder cancer: a comprehensive review. 61
31961624 2020
6
Primary small cell carcinoma of the ureter with hydronephrosis: A case report. 61
31908961 2020
7
The outcomes of mini-laparoscopic pyeloplasty in children - brazilian experience. 61
32022515 2020
8
Segmental Ureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis of Comparative Studies. 61
31704265 2020
9
Prenatal Diagnosis of Megacystitis and Hydronephrosis in an Equine Fetus: How Transabdominal Ultrasonography Can Help to Diagnose Fetal Abnormalities. 61
31952643 2020
10
Antibiotic Prophylaxis Prescribing Patterns of Pediatric Urologists for Children with Vesicoureteral Reflux and other Congenital Anomalies of the Kidney and Urinary Tract. 61
31758980 2020
11
Clinical characteristics and outcome of childhood vesicoureteral reflux. 61
31984697 2020
12
Congenital Anomalies of the Kidney and Urinary Tract in Children with Congenital Heart Defects. 61
32018253 2020
13
Use of pediatric donor en bloc kidneys along with bladder segment in pediatric liver-kidney and multivisceral-kidney transplantation. 61
31605438 2020
14
Sonographic Evaluation for Endometriosis in Routine Pelvic Ultrasound. 61
31493569 2020
15
The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer. 61
31552530 2020
16
Incidence, management, and sequelae of ureteric obstruction in women with cervical cancer. 61
31129761 2020
17
Clinicopathologic features of the ureteral neuroendocrine tumors. 61
31859117 2020
18
Pathogenic copy number variants are detected in a subset of patients with gastrointestinal malformations. 61
31837127 2020
19
Comparative Study of Retroperitoneal Laparoscopic Versus Open Ipsilateral Nephrectomy After Percutaneous Nephrostomy: A Multicenter Analysis. 61
32027216 2020
20
Diagnostic Capacity of Pocket-Sized Ultrasound Devices at Point of Care by a Non-radiologist Resident in Patients with Suspected Abdominal Pathology. 61
31767453 2020
21
[Diagnostic management of primary megaureter : Voiding cystourethrography obligatory, scintigraphy useful?] 61
32030434 2020
22
More Than a Myoma: A Review of Myomatous Erythrocytosis Syndrome. 61
30904341 2020
23
Ultrasound guidance can be used safely for renal tract dilatation during percutaneous nephrolithotomy. 61
30811835 2020
24
Prospective development of a patient-reported outcomes instrument for desmoid tumors or aggressive fibromatosis. 61
31691276 2020
25
Renal Pelvis Metastasis From Prostatic Adenocarcinoma Missed by PSMA PET: A Case Report. 61
31733274 2020
26
Cystatin C in Evaluating Renal Function in Ureteral Calculi Hydronephrosis in Adults. 61
31801142 2020
27
Is Absence of Hydronephrosis a Risk Factor for Bleeding in Conventional Percutaneous Nephrolithotomy. 61
30882169 2020
28
Treatment of renal calculi without hydronephrosis using a standard channel assisted by a visual puncture system. 61
31939324 2020
29
Predictive values of haematuria and hydronephrosis in suspected renal colic: An emergency department retrospective audit. 61
31958894 2020
30
Multiple Congenital Anomalies in a Patient with Interstitial 6q26 Deletion. 61
32021599 2020
31
Value of routine ultrasound examination at 35-37 weeks' gestation in diagnosis of fetal abnormalities. 61
31595569 2020
32
Hereditary bilateral ureteropelvic junction obstruction. 61
31984459 2020
33
Virtual Three-Dimensional Magnetic Resonance Fetal Cystoscopy: A Novel Modality for Precise in Utero Evaluation of Urinary Tract. 61
30471075 2020
34
The Frequency of Familial Congenital Anomalies of the Kidney and Urinary Tract: Should We Screen Asymptomatic First-Degree Relatives Using Urinary Tract Ultrasonography? 61
31910412 2020
35
Focused Assessment with Sonography for Urinary Schistosomiasis (FASUS)-pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings. 61
31735956 2020
36
Urologic Conditions in Infants and Children: Circumcision. 61
31894950 2020
37
Megaesophagus Is a Major Pathological Condition in Rats With a Large Deletion in the Rbm20 Gene. 61
31221019 2020
38
[Laparoscopic radical cystectomy: novel technique with late dividing of the ureters]. 61
32003168 2020
39
Neurogenic bladder monitoring using the cystomanometer and cystoelastometer. 61
32005418 2020
40
Diabetic ketoacidosis complicated by emphysematous pyelonephritis: a case report and literature review. 61
31996190 2020
41
A Comparative Analysis of Bladder Pattern of Patients who Underwent In Utero Versus Postnatal Myelomeningocele Repair. 61
31479395 2020
42
Validation of "urinary tract dilation" classification system: Correlation between fetal hydronephrosis and postnatal urological abnormalities. 61
31914077 2020
43
A novel interstitial deletion of chromosome 2q21.1-q23.3: Case report and literature review. 61
31989799 2020
44
Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated with Congenital Anomalies of the Kidney and Urinary Tract. 61
31862704 2020
45
Duplex kidney formation: developmental mechanisms and genetic predisposition. 61
32030122 2020
46
The old becomes new: advances in imaging techniques to assess nephron mass in children. 61
31953750 2020
47
[Primary Ureteral Small Cell Carcinoma with Multiple Recurrences and Metastases in the Early Postoperative Period : A Case Report]. 61
32028751 2020
48
An overview of hydronephrosis in adults. 61
32003628 2020
49
Antenatal hydronephrosis and fetal urine sampling. 61
30629771 2020
50
Pediatric bladder augmentation - Panacea or Pandora's box? 61
31977304 2020

Variations for Hydronephrosis

ClinVar genetic disease variations for Hydronephrosis:

6 (show all 13) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 WFS1 NM_006005.3(WFS1):c.1999C>T (p.Gln667Ter)SNV Pathogenic 598973 rs771409809 4:6303521-6303521 4:6301794-6301794
2 C12orf57 NM_138425.4(C12orf57):c.53-2A>GSNV Pathogenic 242885 rs1114167293 12:7053637-7053637 12:6944474-6944474
3 46;XY;inv(6)(p22q13)dninversion Pathogenic 267941
4 TBX4 NM_001321120.2(TBX4):c.402G>A (p.Trp134Ter)SNV Pathogenic 638159 17:59544871-59544871 17:61467510-61467510
5 PGM1 NM_002633.3(PGM1):c.804T>A (p.Tyr268Ter)SNV Likely pathogenic 694645 1:64100621-64100621 1:63634950-63634950
6 SETBP1 NM_015559.3(SETBP1):c.2614G>A (p.Gly872Arg)SNV Likely pathogenic 523513 rs1555706928 18:42531919-42531919 18:44951954-44951954
7 CHN1 NM_001822.5(CHN1):c.667G>A (p.Ala223Thr)SNV Likely pathogenic 598971 rs1558939623 2:175689207-175689207 2:174824479-174824479
8 KIF1A NM_004321.7(KIF1A):c.2749C>T (p.His917Tyr)SNV Uncertain significance 598972 rs1356639316 2:241686664-241686664 2:240747247-240747247
9 XDH NM_000379.4(XDH):c.1172C>T (p.Pro391Leu)SNV Uncertain significance 598996 rs1558697792 2:31602803-31602803 2:31379937-31379937
10 GATA4 NM_002052.5(GATA4):c.94G>C (p.Ala32Pro)SNV Uncertain significance 599008 rs773545065 8:11565915-11565915 8:11708406-11708406
11 ERF NM_006494.4(ERF):c.1636C>T (p.Arg546Ter)SNV Uncertain significance 599007 rs764412749 19:42752628-42752628 19:42248476-42248476
12 FLNA NM_001110556.2(FLNA):c.3934C>T (p.Arg1312Cys)SNV Uncertain significance 617640 rs781928289 X:153588145-153588145 X:154359777-154359777
13 XDH NM_000379.4(XDH):c.3647C>A (p.Pro1216His)SNV Uncertain significance 335760 rs143981573 2:31562482-31562482 2:31339616-31339616

Expression for Hydronephrosis

Search GEO for disease gene expression data for Hydronephrosis.

Pathways for Hydronephrosis

GO Terms for Hydronephrosis

Cellular components related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.92 VEGFA TGFB1 EGF ALB

Biological processes related to Hydronephrosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 VEGFA TGFB1 OSR1 IL6 ID2 EGF
2 angiogenesis GO:0001525 9.78 VEGFA TBX4 EGF CCL2
3 cellular protein metabolic process GO:0044267 9.73 WFS1 IL6 B2M ALB
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.7 VEGFA TGFB1 IL6
5 negative regulation of DNA-binding transcription factor activity GO:0043433 9.63 WFS1 ID2 FLNA
6 positive regulation of epithelial cell proliferation GO:0050679 9.58 VEGFA TGFB1 OSR1
7 lung development GO:0030324 9.56 ZIC3 VEGFA TBX4 MME
8 positive regulation of MAP kinase activity GO:0043406 9.54 VEGFA TGFB1 EGF
9 locomotor rhythm GO:0045475 9.51 NAGLU ID2
10 positive regulation of vascular permeability GO:0043117 9.49 VEGFA TGFB1
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 VEGFA TGFB1 IL6 EGF
12 mammary gland alveolus development GO:0060749 9.13 VEGFA ID2 EGF
13 platelet degranulation GO:0002576 9.02 VEGFA TGFB1 FLNA EGF ALB

Molecular functions related to Hydronephrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 VEGFA TGFB1 IL6 CCL2
2 growth factor activity GO:0008083 8.92 VEGFA TGFB1 IL6 EGF

Sources for Hydronephrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
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68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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