Aliases & Classifications for Hydrophthalmos

MalaCards integrated aliases for Hydrophthalmos:

Name: Hydrophthalmos 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11212
ICD10 33 Q15.0
ICD9CM 35 743.2 743.20
MeSH 44 D006871
NCIt 50 C50648
SNOMED-CT 68 13832009
UMLS 73 C0020302

Summaries for Hydrophthalmos

MalaCards based summary : Hydrophthalmos is related to juvenile glaucoma and glaucoma 3, primary congenital, a. An important gene associated with Hydrophthalmos is OPTN (Optineurin), and among its related pathways/superpathways is Heart Development. The drugs Bevacizumab and Angiogenesis Modulating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and endothelial, and related phenotype is vision/eye.

Wikipedia : 76 Hydrophthalmos is a congenital form of... more...

Related Diseases for Hydrophthalmos

Diseases related to Hydrophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 juvenile glaucoma 31.1 CYP1B1 FOXC1 OPTN PITX2
2 glaucoma 3, primary congenital, a 30.2 CYP1B1 FBXO7 FOXC1 LTBP2 OPTN PITX2
3 acrofrontofacionasal dysostosis 10.1 CYP1B1 OPTN
4 glaucoma 1, open angle, a 10.1 CYP1B1 OPTN
5 cataract 10.1
6 myopia 10.1
7 ritscher-schinzel syndrome 10.1 FOXC1 OPTN
8 primary angle-closure glaucoma 10.1 CYP1B1 OPTN
9 panophthalmitis 10.1 FBXO7 OPTN
10 glaucoma 3, primary infantile, b 10.0 CYP1B1 LTBP2
11 purulent endophthalmitis 10.0 FBXO7 OPTN
12 amblyopia 10.0 FBXO7 OPTN
13 corneal endothelial dystrophy 10.0 FBXO7 OPTN
14 glaucoma, primary open angle 10.0 CYP1B1 OPTN
15 glaucoma-related pigment dispersion syndrome 9.9 CYP1B1 PITX2
16 early-onset glaucoma 9.9 CYP1B1 PITX2
17 anterior segment dysgenesis 4 9.9 FOXC1 PITX2
18 excessive tearing 9.9 CYP1B1 LTBP2 OPTN
19 intestinal atresia 9.9 FOXC1 PITX2
20 persistent hyperplastic primary vitreous 9.9 FOXC1 PITX2
21 coloboma of macula 9.9 CYP1B1 OPTN
22 open-angle glaucoma 9.9 CYP1B1 LTBP2 OPTN
23 megalocornea 9.9 LTBP2 OPTN SH3PXD2B
24 axenfeld-rieger syndrome, type 2 9.8 FOXC1 OPTN PITX2
25 iris disease 9.8 FOXC1 OPTN PITX2
26 axenfeld-rieger syndrome, type 3 9.8 CYP1B1 FOXC1 PITX2
27 fuchs' endothelial dystrophy 9.8 FBXO7 PITX2
28 anterior segment dysgenesis 9.8 CYP1B1 FOXC1 PITX2
29 peters-plus syndrome 9.8 CYP1B1 FOXC1 PITX2
30 corneal edema 9.7 CYP1B1 FBXO7 LTBP2 OPTN
31 axenfeld-rieger syndrome 9.7 CYP1B1 FOXC1 OPTN PITX2
32 aniridia 1 9.7 CYP1B1 FOXC1 OPTN PITX2
33 adamantinoma of long bones 9.7 CYP1B1 FOXC1 OPTN PITX2
34 primary congenital glaucoma 9.2 CYP1B1 FOXC1 LTBP2 OPTN PITX2 SH3PXD2B

Graphical network of the top 20 diseases related to Hydrophthalmos:



Diseases related to Hydrophthalmos

Symptoms & Phenotypes for Hydrophthalmos

MGI Mouse Phenotypes related to Hydrophthalmos:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 CYP1B1 FOXC1 LTBP2 PITX2 SH3PXD2B

Drugs & Therapeutics for Hydrophthalmos

Drugs for Hydrophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Modulating Agents Phase 4
3 Angiogenesis Inhibitors Phase 4
4
Travoprost Approved Phase 3,Phase 1 157283-68-6 5282226
5
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
6
Timolol Approved Phase 3 26839-75-8 33624 5478
7 tannic acid Approved Phase 3
8
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
9
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
10 Antihypertensive Agents Phase 3,Phase 2,Phase 1
11 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
12 Ophthalmic Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
13 Neurotransmitter Agents Phase 3
14 Adrenergic Agents Phase 3
15 Anti-Arrhythmia Agents Phase 3
16 Adrenergic beta-Antagonists Phase 3
17 Adrenergic Antagonists Phase 3
18 topoisomerase I inhibitors Phase 3
19 Topoisomerase Inhibitors Phase 3
20
Latanoprost Approved, Investigational Phase 2 130209-82-4 5311221 5282380
21
Dorzolamide Approved Phase 2 120279-96-1 5284549 3154
22 Carbonic Anhydrase Inhibitors Phase 2
23
Tetracaine Approved, Vet_approved Early Phase 1 94-24-6 5411
24
Sevoflurane Approved, Vet_approved Early Phase 1 28523-86-6 5206
25
Nitrous oxide Approved, Vet_approved Early Phase 1 10024-97-2 948
26 Peripheral Nervous System Agents Early Phase 1
27 Central Nervous System Depressants Early Phase 1
28 Anesthetics Early Phase 1
29 Anesthetics, Local Early Phase 1
30 Analgesics Early Phase 1
31 Platelet Aggregation Inhibitors Early Phase 1
32 Analgesics, Non-Narcotic Early Phase 1
33 Anesthetics, General Early Phase 1
34 Anesthetics, Inhalation Early Phase 1
35 Anti-Bacterial Agents Not Applicable
36 Nucleic Acid Synthesis Inhibitors Not Applicable
37 Antibiotics, Antitubercular Not Applicable
38 Mitomycins Not Applicable
39 Alkylating Agents Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma Unknown status NCT01494974 Phase 4
2 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
3 Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients Completed NCT01652664 Phase 3 Travoprost 0.004% PQ ophthalmic solution;Timolol, 0.5% or 0.25% ophthalmic solution;Travoprost Vehicle
4 Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma Recruiting NCT03475121 Phase 3
5 Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma Unknown status NCT01527682 Phase 2 Latanoprost, Dorzolamide
6 Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma Unknown status NCT02121171 Phase 1
7 Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma Unknown status NCT01460017 Phase 1
8 Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients Completed NCT01658839 Phase 1 Travoprost ophthalmic solution, 0.004% (new formulation)
9 The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma Unknown status NCT01020721
10 Endoscopic Goniotomy for Infantile Glaucoma Completed NCT00338533 Not Applicable
11 Quality of Life in Children Glaucoma and Cataract Completed NCT02490267
12 The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops Completed NCT01925391 Early Phase 1 Tono-pen XL Applanation tonometer + Ocu-film +
13 Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation Completed NCT02945176 Not Applicable
14 Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases Completed NCT00076271
15 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509
16 Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France Recruiting NCT03077789 Not Applicable
17 Genetic Testing in Primary Congenital Glaucoma Patients Recruiting NCT01136460
18 Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma Recruiting NCT03016156 Not Applicable
19 Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children Recruiting NCT01290588
20 Repository for Inherited Eye Diseases Active, not recruiting NCT00378742
21 Ologen® Collagen Matrix in Patients With Primary Congenital Glaucoma Undergoing Trabeculectomy Not yet recruiting NCT03541551 Not Applicable
22 Ologen® Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma Not yet recruiting NCT03548805 Not Applicable

Search NIH Clinical Center for Hydrophthalmos

Cochrane evidence based reviews: hydrophthalmos

Genetic Tests for Hydrophthalmos

Anatomical Context for Hydrophthalmos

MalaCards organs/tissues related to Hydrophthalmos:

41
Eye, Bone, Endothelial

Publications for Hydrophthalmos

Articles related to Hydrophthalmos:

# Title Authors Year
1
A contribution to the surgical treatment of hydrophthalmos. ( 5893381 )
1965
2
PERSISTENT PUPILLARY MEMBRANE; ASSOCIATED WITH HYDROPHTHALMOS, CORECTOPIA, CATARACT AND MYOPIA. ( 14070714 )
1963
3
Hydrophthalmos and neurofibromatosis (von Recklinghausen). ( 13652533 )
1959
4
Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation; a clinical entity. ( 14884753 )
1952
5
A Collective Study of the Treatment of Congenital Hydrophthalmos. ( 16692688 )
1924
6
Hydrophthalmos (Buphthalmos or Infantile Glaucoma)-Report of a Case with Microscopic Findings. ( 16692647 )
1923

Variations for Hydrophthalmos

Expression for Hydrophthalmos

Search GEO for disease gene expression data for Hydrophthalmos.

Pathways for Hydrophthalmos

Pathways related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 FOXC1 PITX2

GO Terms for Hydrophthalmos

Biological processes related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anatomical structure morphogenesis GO:0009653 9.26 FOXC1 PITX2
2 camera-type eye development GO:0043010 9.16 FOXC1 PITX2
3 collagen fibril organization GO:0030199 8.96 CYP1B1 FOXC1
4 eye development GO:0001654 8.62 FOXC1 SH3PXD2B

Sources for Hydrophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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