Aliases & Classifications for Hydrophthalmos

MalaCards integrated aliases for Hydrophthalmos:

Name: Hydrophthalmos 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11212
ICD9CM 36 743.2 743.20
MeSH 45 D006871
NCIt 51 C50648
SNOMED-CT 69 13832009
ICD10 34 Q15.0
UMLS 74 C0020302

Summaries for Hydrophthalmos

MalaCards based summary : Hydrophthalmos is related to juvenile glaucoma and glaucoma 3, primary congenital, a. An important gene associated with Hydrophthalmos is CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1), and among its related pathways/superpathways are Elastic fibre formation and Aryl Hydrocarbon Receptor. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related phenotypes are craniofacial and respiratory system

Wikipedia : 77 Hydrophthalmos is a congenital form of... more...

Related Diseases for Hydrophthalmos

Graphical network of the top 20 diseases related to Hydrophthalmos:



Diseases related to Hydrophthalmos

Symptoms & Phenotypes for Hydrophthalmos

MGI Mouse Phenotypes related to Hydrophthalmos:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.56 FOXC1 LTBP3 NF1 PITX2
2 respiratory system MP:0005388 9.35 FOXC1 LTBP2 LTBP3 NF1 PITX2
3 pigmentation MP:0001186 9.33 FOXC1 NF1 PITX2
4 vision/eye MP:0005391 9.1 CYP1B1 FOXC1 LTBP2 LTBP3 NF1 PITX2

Drugs & Therapeutics for Hydrophthalmos

Drugs for Hydrophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4 Antineoplastic Agents, Immunological Phase 4
5
Timolol Approved Phase 3 26839-75-8 33624 5478
6
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
7
Travoprost Approved Phase 3,Phase 1 157283-68-6 5282226
8
tannic acid Approved Phase 3 1401-55-4
9
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
10
Carboplatin Approved Phase 3 41575-94-4 38904 10339178 498142
11 Ophthalmic Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
12 Antihypertensive Agents Phase 3,Phase 2,Phase 1
13 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
14 Anti-Arrhythmia Agents Phase 3
15 Neurotransmitter Agents Phase 3
16 Adrenergic beta-Antagonists Phase 3
17 Adrenergic Antagonists Phase 3
18 Adrenergic Agents Phase 3
19 Topoisomerase Inhibitors Phase 3
20 topoisomerase I inhibitors Phase 3
21
Dorzolamide Approved Phase 2 120279-96-1 3154 5284549
22
Latanoprost Approved, Investigational Phase 2 130209-82-4 5311221 5282380
23 Carbonic Anhydrase Inhibitors Phase 2
24
Tetracaine Approved, Vet_approved Early Phase 1 94-24-6 5411
25
Nitrous oxide Approved, Vet_approved Early Phase 1 10024-97-2 948
26
Sevoflurane Approved, Vet_approved Early Phase 1 28523-86-6 5206
27 Anesthetics Early Phase 1
28 Anesthetics, Inhalation Early Phase 1
29 Anesthetics, Local Early Phase 1
30 Central Nervous System Depressants Early Phase 1
31 Peripheral Nervous System Agents Early Phase 1
32 Analgesics, Non-Narcotic Early Phase 1
33 Platelet Aggregation Inhibitors Early Phase 1
34 Anesthetics, General Early Phase 1
35 Analgesics Early Phase 1
36 Nucleic Acid Synthesis Inhibitors Not Applicable
37 Alkylating Agents Not Applicable
38 Antibiotics, Antitubercular Not Applicable
39 Anti-Bacterial Agents Not Applicable
40 Mitomycins Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma Unknown status NCT01494974 Phase 4
2 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
3 Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients Completed NCT01652664 Phase 3 Travoprost 0.004% PQ ophthalmic solution;Timolol, 0.5% or 0.25% ophthalmic solution;Travoprost Vehicle
4 Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma Recruiting NCT03475121 Phase 3
5 Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma Unknown status NCT01527682 Phase 2 Latanoprost, Dorzolamide
6 Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma Unknown status NCT02121171 Phase 1
7 Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma Unknown status NCT01460017 Phase 1
8 Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients Completed NCT01658839 Phase 1 Travoprost ophthalmic solution, 0.004% (new formulation)
9 The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma Unknown status NCT01020721
10 Endoscopic Goniotomy for Infantile Glaucoma Completed NCT00338533 Not Applicable
11 Quality of Life in Children Glaucoma and Cataract Completed NCT02490267
12 The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops Completed NCT01925391 Early Phase 1 Tono-pen XL Applanation tonometer + Ocu-film +
13 Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation Completed NCT02945176 Not Applicable
14 Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases Completed NCT00076271
15 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509
16 Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France Recruiting NCT03077789 Not Applicable
17 Genetic Testing in Primary Congenital Glaucoma Patients Recruiting NCT01136460
18 Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma Recruiting NCT03016156 Not Applicable
19 Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children Recruiting NCT01290588
20 Repository for Inherited Eye Diseases Active, not recruiting NCT00378742
21 Ologen® Collagen Matrix in Patients With Primary Congenital Glaucoma Undergoing Trabeculectomy Not yet recruiting NCT03541551 Not Applicable
22 Ologen® Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma Not yet recruiting NCT03548805 Not Applicable

Search NIH Clinical Center for Hydrophthalmos

Cochrane evidence based reviews: hydrophthalmos

Genetic Tests for Hydrophthalmos

Anatomical Context for Hydrophthalmos

MalaCards organs/tissues related to Hydrophthalmos:

42
Eye, Testes

Publications for Hydrophthalmos

Articles related to Hydrophthalmos:

# Title Authors Year
1
A contribution to the surgical treatment of hydrophthalmos. ( 5893381 )
1965
2
PERSISTENT PUPILLARY MEMBRANE; ASSOCIATED WITH HYDROPHTHALMOS, CORECTOPIA, CATARACT AND MYOPIA. ( 14070714 )
1963
3
Hydrophthalmos and neurofibromatosis (von Recklinghausen). ( 13652533 )
1959
4
Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation; a clinical entity. ( 14884753 )
1952
5
A Collective Study of the Treatment of Congenital Hydrophthalmos. ( 16692688 )
1924
6
Hydrophthalmos (Buphthalmos or Infantile Glaucoma)-Report of a Case with Microscopic Findings. ( 16692647 )
1923

Variations for Hydrophthalmos

Expression for Hydrophthalmos

Search GEO for disease gene expression data for Hydrophthalmos.

Pathways for Hydrophthalmos

Pathways related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.02 LTBP2 LTBP3
2 10.64 CYP1B1 NF1
3 10.29 FOXC1 PITX2

GO Terms for Hydrophthalmos

Biological processes related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 camera-type eye development GO:0043010 9.16 FOXC1 PITX2
2 artery morphogenesis GO:0048844 8.96 FOXC1 NF1
3 collagen fibril organization GO:0030199 8.8 CYP1B1 FOXC1 NF1

Molecular functions related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 LTBP2 LTBP3

Sources for Hydrophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....