Aliases & Classifications for Hydrophthalmos

Summaries for Hydrophthalmos

MalaCards based summary : Hydrophthalmos is related to juvenile glaucoma and glaucoma 3, primary congenital, a. An important gene associated with Hydrophthalmos is OPTN (Optineurin), and among its related pathways/superpathways is Heart Development. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related phenotype is vision/eye.

Wikipedia : 76 Hydrophthalmos is a congenital form of... more...

Related Diseases for Hydrophthalmos

Diseases related to Hydrophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 juvenile glaucoma 29.6 CYP1B1 FOXC1 OPTN PITX2
2 glaucoma 3, primary congenital, a 27.6 CYP1B1 FBXO7 FOXC1 LTBP2 OPTN PITX2
3 acrofrontofacionasal dysostosis 10.3 CYP1B1 OPTN
4 glaucoma 1, open angle, a 10.3 CYP1B1 OPTN
5 glaucoma 3, primary infantile, b 10.2 CYP1B1 LTBP2
6 ritscher-schinzel syndrome 10.2 FOXC1 OPTN
7 megalocornea 10.1 LTBP2 OPTN
8 panophthalmitis 10.1 FBXO7 OPTN
9 phacogenic glaucoma 10.1 LTBP2 OPTN
10 primary angle-closure glaucoma 10.0 CYP1B1 OPTN
11 cataract 9.9
12 myopia 9.9
13 purulent endophthalmitis 9.9 FBXO7 OPTN
14 glaucoma-related pigment dispersion syndrome 9.8 CYP1B1 PITX2
15 glaucoma, primary open angle 9.8 CYP1B1 OPTN
16 corneal endothelial dystrophy 9.8 FBXO7 OPTN
17 early-onset glaucoma 9.8 CYP1B1 PITX2
18 axenfeld-rieger syndrome, type 3 9.7 FOXC1 PITX2
19 excessive tearing 9.7 CYP1B1 LTBP2 OPTN
20 open-angle glaucoma 9.7 CYP1B1 LTBP2 OPTN
21 anterior segment dysgenesis 4 9.7 FOXC1 PITX2
22 cornea plana 9.6 FOXC1 PITX2
23 intestinal atresia 9.6 FOXC1 PITX2
24 coloboma of macula 9.6 CYP1B1 OPTN
25 persistent hyperplastic primary vitreous 9.5 FOXC1 PITX2
26 axenfeld-rieger syndrome, type 2 9.3 FOXC1 OPTN PITX2
27 iris disease 9.3 FOXC1 OPTN PITX2
28 anterior segment dysgenesis 9.2 CYP1B1 FOXC1 PITX2
29 fuchs' endothelial dystrophy 9.2 FBXO7 PITX2
30 peters-plus syndrome 9.2 CYP1B1 FOXC1 PITX2
31 corneal edema 9.0 CYP1B1 FBXO7 LTBP2 OPTN
32 intraocular pressure quantitative trait locus 8.8 CYP1B1 FOXC1 OPTN PITX2
33 axenfeld-rieger syndrome 8.8 CYP1B1 FOXC1 OPTN PITX2
34 aniridia 1 8.8 CYP1B1 FOXC1 OPTN PITX2
35 primary congenital glaucoma 8.2 CYP1B1 FOXC1 LTBP2 OPTN PITX2

Graphical network of the top 20 diseases related to Hydrophthalmos:



Diseases related to Hydrophthalmos

Symptoms & Phenotypes for Hydrophthalmos

MGI Mouse Phenotypes related to Hydrophthalmos:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.92 CYP1B1 FOXC1 LTBP2 PITX2

Drugs & Therapeutics for Hydrophthalmos

Drugs for Hydrophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
5
Timolol Approved Phase 3 26839-75-8 33624 5478
6
Travoprost Approved Phase 3,Phase 1 157283-68-6 5282226
7 tannic acid Approved, Nutraceutical Phase 3
8 Antihypertensive Agents Phase 3,Phase 2,Phase 1
9 Ophthalmic Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
10 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
11 Adrenergic Agents Phase 3
12 Adrenergic Antagonists Phase 3
13 Adrenergic beta-Antagonists Phase 3
14 Anti-Arrhythmia Agents Phase 3
15 Neurotransmitter Agents Phase 3
16
Dorzolamide Approved Phase 2 120279-96-1 3154 5284549
17
Latanoprost Approved, Investigational Phase 2 130209-82-4 5282380 5311221
18 Carbonic Anhydrase Inhibitors Phase 2
19
Nitrous oxide Approved, Vet_approved Early Phase 1 10024-97-2 948
20
Sevoflurane Approved, Vet_approved Early Phase 1 28523-86-6 5206
21
Tetracaine Approved, Vet_approved Early Phase 1 94-24-6 5411
22
Menthol Approved Not Applicable 2216-51-5 16666
23 Analgesics Early Phase 1
24 Analgesics, Non-Narcotic Early Phase 1
25 Anesthetics Early Phase 1
26 Anesthetics, General Early Phase 1
27 Anesthetics, Inhalation Early Phase 1
28 Anesthetics, Local Early Phase 1
29 Central Nervous System Depressants Early Phase 1
30 Peripheral Nervous System Agents Early Phase 1
31 Platelet Aggregation Inhibitors Early Phase 1
32 Tetrahydrozoline Early Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma Unknown status NCT01494974 Phase 4
2 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
3 Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients Completed NCT01652664 Phase 3 Travoprost 0.004% PQ ophthalmic solution;Timolol, 0.5% or 0.25% ophthalmic solution;Travoprost Vehicle
4 Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma Recruiting NCT03475121 Phase 3
5 Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma Unknown status NCT01527682 Phase 2 Latanoprost, Dorzolamide
6 Combined Trab+Trab Versus Combined Trab+Trab With Subconjunctival Implantation of Ologen for Primary Congenital Glaucoma Unknown status NCT02121171 Phase 1
7 Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma Unknown status NCT01460017 Phase 1
8 Pharmacokinetic and Safety Study of Travoprost 0.004% in Pediatric Glaucoma Patients Completed NCT01658839 Phase 1 Travoprost ophthalmic solution, 0.004% (new formulation)
9 The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma Unknown status NCT01020721
10 Endoscopic Goniotomy for Infantile Glaucoma Completed NCT00338533 Not Applicable
11 Quality of Life in Children Glaucoma and Cataract Completed NCT02490267
12 The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops Completed NCT01925391 Early Phase 1 Tono-pen XL Applanation tonometer + Ocu-film +
13 Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation Completed NCT02945176 Not Applicable
14 Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases Completed NCT00076271
15 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509
16 Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France Recruiting NCT03077789 Not Applicable
17 Genetic Testing in Primary Congenital Glaucoma Patients Recruiting NCT01136460
18 Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma Recruiting NCT03016156 Not Applicable
19 Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children Recruiting NCT01290588
20 Repository for Inherited Eye Diseases Active, not recruiting NCT00378742
21 Ologen® Collagen Matrix in Patients With Primary Congenital Glaucoma Undergoing Trabeculectomy Not yet recruiting NCT03541551 Not Applicable
22 Ologen® Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma Not yet recruiting NCT03548805 Not Applicable

Search NIH Clinical Center for Hydrophthalmos

Cochrane evidence based reviews: hydrophthalmos

Genetic Tests for Hydrophthalmos

Anatomical Context for Hydrophthalmos

MalaCards organs/tissues related to Hydrophthalmos:

41
Eye, Testes

Publications for Hydrophthalmos

Articles related to Hydrophthalmos:

# Title Authors Year
1
A contribution to the surgical treatment of hydrophthalmos. ( 5893381 )
1965
2
PERSISTENT PUPILLARY MEMBRANE; ASSOCIATED WITH HYDROPHTHALMOS, CORECTOPIA, CATARACT AND MYOPIA. ( 14070714 )
1963
3
Hydrophthalmos and neurofibromatosis (von Recklinghausen). ( 13652533 )
1959
4
Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation; a clinical entity. ( 14884753 )
1952
5
A Collective Study of the Treatment of Congenital Hydrophthalmos. ( 16692688 )
1924
6
Hydrophthalmos (Buphthalmos or Infantile Glaucoma)-Report of a Case with Microscopic Findings. ( 16692647 )
1923

Variations for Hydrophthalmos

Expression for Hydrophthalmos

Search GEO for disease gene expression data for Hydrophthalmos.

Pathways for Hydrophthalmos

Pathways related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 FOXC1 PITX2

GO Terms for Hydrophthalmos

Biological processes related to Hydrophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anatomical structure morphogenesis GO:0009653 9.32 FOXC1 PITX2
2 camera-type eye development GO:0043010 9.26 FOXC1 PITX2
3 odontogenesis of dentin-containing tooth GO:0042475 9.16 FOXC1 PITX2
4 collagen fibril organization GO:0030199 8.96 CYP1B1 FOXC1
5 positive regulation of DNA binding GO:0043388 8.62 FOXC1 PITX2

Sources for Hydrophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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