MCID: HYD038
MIFTS: 49

Hydrops Fetalis, Nonimmune

Categories: Fetal diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Hydrops Fetalis, Nonimmune

MalaCards integrated aliases for Hydrops Fetalis, Nonimmune:

Name: Hydrops Fetalis, Nonimmune 57 55 40
Non-Immune Hydrops Fetalis 59 29 6
Hydrops Fetalis 59 73
Hemoglobin Bart's Hydrops Syndrome 73
Alpha-Thalassemia Hydrops Fetalis 59
Hemoglobin Bart's Hydrops Fetalis 59
Homozygous Alpha0-Thalassemia 59
Hydrops Fetalis, Non-Immune 73
Hb Bart's Hydrops Fetalis 59
Non-Immune Fetal Hydrops 59
Alpha-Thalassemia Major 59
Generalized Fetal Edema 59
Non-Immune Fetal Edema 59
Fetal Anasarca 59
Fetal Hydrops 59
Non-Immune Hf 59
Nihf 57
Hf 59

Characteristics:

Orphanet epidemiological data:

59
hb bart's hydrops fetalis
Inheritance: Autosomal recessive; Prevalence: >1/1000 (South East Asia); Age of onset: Infancy,Neonatal;
hydrops fetalis
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;
non-immune hydrops fetalis
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

OMIM:

57
Inheritance:
multifactorial

Miscellaneous:
onset in utero
pre- or perinatal death often occurs
heterogeneous causes


HPO:

32
hydrops fetalis, nonimmune:
Onset and clinical course congenital onset


Classifications:



External Ids:

OMIM 57 236750
ICD10 via Orphanet 34 D56.0 P83.2 P56.0 more
MESH via Orphanet 45 D015160
UMLS via Orphanet 74 C0020305 C0455988
MedGen 42 C0455988

Summaries for Hydrops Fetalis, Nonimmune

OMIM : 57 Hydrops fetalis is a descriptive term for generalized edema of the fetus, with fluid accumulation in extravascular components and body cavities. It is not a diagnosis in itself, but a symptom and end-stage result of a wide variety of disorders. In the case of immune hydrops fetalis, a frequent cause is maternofetal incompatibility as in that related to a number of genetic anemias and metabolic disorders expressed in the fetus; in other instances, it remains idiopathic and likely multifactorial (summary by Bellini et al., 2009). Nonimmune hydrops fetalis accounts for 76 to 87% of all described cases of hydrops fetalis (Bellini et al., 2009). (236750)

MalaCards based summary : Hydrops Fetalis, Nonimmune, also known as non-immune hydrops fetalis, is related to hydrops fetalis and alpha-thalassemia, and has symptoms including edema and peau d'orange. An important gene associated with Hydrops Fetalis, Nonimmune is NEU1 (Neuraminidase 1), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Malaria. Affiliated tissues include heart, pituitary and lung, and related phenotypes are hydrocephalus and pallor

Related Diseases for Hydrops Fetalis, Nonimmune

Diseases related to Hydrops Fetalis, Nonimmune via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 hydrops fetalis 31.5 EPHB4 HBA1 HBA2
2 alpha-thalassemia 29.6 HBA1 HBA2
3 thalassemia 28.5 HBA1 HBA2
4 hydrops fetalis, nonimmune, and/or atrial septal defect 12.6
5 hydrops fetalis, nonimmune, with gracile bones and dysmorphic features 12.3
6 hyaline fibromatosis syndrome 11.7
7 galactosialidosis 11.4
8 hemifacial spasm 11.3
9 greenberg dysplasia 11.1
10 immune hydrops fetalis 11.1
11 lymphedema, hereditary, iii 11.0
12 multiple pterygium syndrome, lethal type 11.0
13 lethal congenital contracture syndrome 1 11.0
14 nephrotic syndrome 14 11.0
15 congestive heart failure 10.9
16 fetal edema 10.6
17 pulmonary sequestration 10.0
18 chorioangioma 9.8
19 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 9.7 HBA1 HBA2
20 methemoglobinemia, beta-globin type 9.7 HBA1 HBA2
21 diabetes mellitus, insulin-dependent, 24 9.7 HBA1 HBA2
22 glutathione peroxidase deficiency 9.7 HBA1 HBA2
23 hypoglycemic coma 9.7 HBA1 HBA2
24 heinz body anemias 9.7 HBA1 HBA2
25 type 1 diabetes mellitus 7 9.7 HBA1 HBA2
26 yellow nail syndrome 9.7
27 noonan syndrome 1 9.7
28 niemann-pick disease, type c1 9.7
29 lymphangiectasia, pulmonary, congenital 9.7
30 wilms tumor 5 9.7
31 megalencephaly-capillary malformation-polymicrogyria syndrome 9.7
32 aplastic anemia 9.7
33 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.7
34 infantile liver failure syndrome 1 9.7
35 wilms tumor 6 9.7
36 chronic granulomatous disease 9.7
37 lymphedema 9.7
38 lysosomal storage disease 9.7
39 niemann-pick disease 9.7
40 sacrococcygeal teratoma 9.7
41 thrombocytopenia 9.7
42 arterial calcification of infancy 9.7
43 desbuquois dysplasia 9.7
44 diaphragmatic eventration 9.7
45 arteriovenous malformation 9.7
46 pancytopenia 9.7
47 tuberous sclerosis 9.7
48 cholestasis 9.7
49 nemaline myopathy 9.7
50 rhabdomyosarcoma 9.7

Graphical network of the top 20 diseases related to Hydrops Fetalis, Nonimmune:



Diseases related to Hydrops Fetalis, Nonimmune

Symptoms & Phenotypes for Hydrops Fetalis, Nonimmune

Symptoms via clinical synopsis from OMIM:

57
Cardiovascular Heart:
pericardial edema

Abdomen:
peritoneal edema

Muscle Soft Tissue:
subcutaneous edema

Respiratory Lung:
pleural edema

Skin Nails Hair Skin:
generalized subcutaneous edema


Clinical features from OMIM:

236750

Human phenotypes related to Hydrops Fetalis, Nonimmune:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydrocephalus 59 32 frequent (33%) Frequent (79-30%) HP:0000238
2 pallor 59 32 hallmark (90%) Very frequent (99-80%) HP:0000980
3 polyhydramnios 59 32 frequent (33%) Frequent (79-30%) HP:0001561
4 oligohydramnios 59 32 frequent (33%) Frequent (79-30%) HP:0001562
5 congestive heart failure 59 32 hallmark (90%) Very frequent (99-80%) HP:0001635
6 pericarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001701
7 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
8 hydrops fetalis 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001789
9 anemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001903
10 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
11 abnormal hemoglobin 59 32 hallmark (90%) Very frequent (99-80%) HP:0011902
12 preeclampsia 59 32 frequent (33%) Frequent (79-30%) HP:0100602
13 nonimmune hydrops fetalis 32 HP:0001790

UMLS symptoms related to Hydrops Fetalis, Nonimmune:


edema, peau d'orange

GenomeRNAi Phenotypes related to Hydrops Fetalis, Nonimmune according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.73 HBA2 HBA1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.73 HBA1 HBA2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.73 HBA2 HBA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.7 HBA2 HBA1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.7 HBA1 HBA2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.7 HBA2 HBA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.7 HBA2 HBA1

Drugs & Therapeutics for Hydrops Fetalis, Nonimmune

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine Treatment Not yet recruiting NCT02956564 Not Applicable
2 Fetal Birth Defects: Toward a Precision-based Approach Not yet recruiting NCT03412760 Not Applicable
3 Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGR Terminated NCT00143039

Search NIH Clinical Center for Hydrops Fetalis, Nonimmune

Genetic Tests for Hydrops Fetalis, Nonimmune

Genetic tests related to Hydrops Fetalis, Nonimmune:

# Genetic test Affiliating Genes
1 Non-Immune Hydrops Fetalis 29

Anatomical Context for Hydrops Fetalis, Nonimmune

MalaCards organs/tissues related to Hydrops Fetalis, Nonimmune:

41
Heart, Pituitary, Lung, Bone

Publications for Hydrops Fetalis, Nonimmune

Articles related to Hydrops Fetalis, Nonimmune:

(show top 50) (show all 82)
# Title Authors Year
1
Thymic teratoma presenting as non-immune hydrops fetalis. ( 29515979 )
2018
2
Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience. ( 28822227 )
2017
3
Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? ( 29076544 )
2017
4
Perinatal and one-year outcomes of non-immune hydrops fetalis by etiology and age at diagnosis. ( 26712114 )
2016
5
A Rare Association of Non-Compaction of the Ventricular Myocardium, and Non-Immune Hydrops Fetalis. ( 27328555 )
2016
6
Congenital Disorder of Glycosylation (CDG) Presenting as Non-immune Hydrops Fetalis. ( 26365158 )
2015
7
Maternal and fetal capillary malformation-arteriovenous malformation (CM-AVM) due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis. ( 26096958 )
2015
8
Etiology of non-immune hydrops fetalis: An update. ( 25712632 )
2015
9
Non-immune Hydrops fetalis due to Parvovirus B19 Infection in 2 Extremely Preterm Infants: Perinatal Management and Long-term Neurodevelopmental Outcome. ( 25830498 )
2015
10
Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. ( 26333996 )
2015
11
Non-immune hydrops fetalis without anemia due to parvovirus B19. ( 24140219 )
2014
12
Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents? ( 25294712 )
2014
13
Accessory diaphragm associated with non-immune hydrops fetalis. ( 25100808 )
2014
14
Transient myeloproliferative disorder and non-immune hydrops fetalis in a neonate with trisomy 21. ( 24473698 )
2014
15
Non-immune hydrops fetalis. ( 24283082 )
2013
16
Non-immune hydrops fetalis: A prospective study of 53 cases. ( 24039125 )
2013
17
Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection. ( 24071962 )
2013
18
CCBE1 mutations can cause a mild, atypical form of generalized lymphatic dysplasia but are not a common cause of non-immune hydrops fetalis. ( 22239599 )
2012
19
Are alanine, cysteine, glycine and valine amino acids the cause of non-immune hydrops fetalis? ( 23157039 )
2012
20
Non-immune hydrops fetalis: a short review of etiology and pathophysiology. ( 22302731 )
2012
21
Short-term and long-term outcomes of 214 cases of non-immune hydrops fetalis. ( 21592689 )
2011
22
Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study. ( 21833460 )
2011
23
Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents? ( 21268039 )
2011
24
Immunohistochemistry in non-immune hydrops fetalis: a single center experience in 79 fetuses. ( 20425823 )
2010
25
Acute non-immune hydrops fetalis caused by intrauterine echovirus infection. ( 22791477 )
2010
26
Successful outcome with intrauterine transfusion in non-immune hydrops fetalis secondary to congenital syphilis. ( 21050519 )
2010
27
Zellweger syndrome with unusual findings: non-immune hydrops fetalis, dermal erythropoiesis and hypoplastic toe nails. ( 20033294 )
2009
28
A diagnostic flow chart for non-immune hydrops fetalis. ( 19334092 )
2009
29
Recurrent non-immune hydrops fetalis with gracile bones and dysmorphic features in siblings. ( 18478587 )
2008
30
Fetal cerebellar hemorrhage in parvovirus-associated non-immune hydrops fetalis. ( 17763280 )
2007
31
Right-sided diaphragmatic eventration: a rare cause of non-immune hydrops fetalis. ( 17596732 )
2007
32
Lysosomal storage diseases in non-immune hydrops fetalis pregnancies. ( 16674934 )
2006
33
Severity of non-immune hydrops fetalis at birth continues to predict survival despite advances in perinatal care. ( 16757915 )
2006
34
Non-immune hydrops fetalis: prenatal diagnosis and perinatal outcomes. ( 15895940 )
2005
35
Etiology and outcome of non-immune hydrops fetalis in southern Thailand. ( 15637431 )
2005
36
Autosomal recessive non-immune hydrops fetalis caused by systemic lymphangiectasia. ( 15690379 )
2005
37
Pearson's syndrome: a rare cause of non-immune hydrops fetalis. ( 14986619 )
2003
38
A new case of mucopolysaccharidosis VII presenting as non immune hydrops fetalis. ( 12748853 )
2003
39
Mucopolysaccharidosis type VII as a cause of recurrent non-immune hydrops fetalis. ( 14711113 )
2003
40
A transgenic mouse model for non-immune hydrops fetalis induced by the NS1 gene of human parvovirus B19. ( 11807219 )
2002
41
A rare case of non-immune hydrops fetalis: double-chambered right ventricle. A case report. ( 11399891 )
2001
42
In utero erythrocyte transfusion for fetal xerocytosis associated with severe anemia and non-immune hydrops fetalis. ( 11483935 )
2001
43
Prenatal diagnosis of intrauterine cytomegalovirus infection in a fetus with non-immune hydrops fetalis. ( 11531622 )
2001
44
Non-immune hydrops fetalis in the first trimester: a review of 30 cases. ( 11530871 )
2001
45
Familial congenital pulmonary lymphangectasia, non-immune hydrops fetalis, facial and lower limb lymphedema: confirmation of Njolstad's report. ( 10946350 )
2000
46
A case of non-immune hydrops fetalis with congenital cystic adenomatoid malformation of the left lung in a twin. ( 11085057 )
2000
47
Direct intrauterine fetal therapy in a case of bronchopulmonary sequestration associated with non-immune hydrops fetalis. ( 10341405 )
1999
48
Long-term outcome of 51 liveborn neonates with non-immune hydrops fetalis. ( 10090542 )
1999
49
[Parvovirus B19 infection in pregnancy: a cause of non-immune hydrops fetalis]. ( 10086088 )
1999
50
Familial non-immune hydrops fetalis and congenital pulmonary lymphangiectasia. ( 9667408 )
1998

Variations for Hydrops Fetalis, Nonimmune

ClinVar genetic disease variations for Hydrops Fetalis, Nonimmune:

6
(show all 37)
# Gene Variation Type Significance SNP ID Assembly Location
1 GUSB NM_000181.3(GUSB): c.1144C> T (p.Arg382Cys) single nucleotide variant Likely pathogenic rs121918173 GRCh37 Chromosome 7, 65439613: 65439613
2 GUSB NM_000181.3(GUSB): c.1144C> T (p.Arg382Cys) single nucleotide variant Likely pathogenic rs121918173 GRCh38 Chromosome 7, 65974626: 65974626
3 GUSB NM_000181.3(GUSB): c.1069C> T (p.Arg357Ter) single nucleotide variant Likely pathogenic rs121918185 GRCh37 Chromosome 7, 65439688: 65439688
4 GUSB NM_000181.3(GUSB): c.1069C> T (p.Arg357Ter) single nucleotide variant Likely pathogenic rs121918185 GRCh38 Chromosome 7, 65974701: 65974701
5 PIGC NM_002642.3(PIGC): c.659T> C (p.Leu220Pro) single nucleotide variant Likely pathogenic rs786205667 GRCh37 Chromosome 1, 172411104: 172411104
6 PIGC NM_002642.3(PIGC): c.659T> C (p.Leu220Pro) single nucleotide variant Likely pathogenic rs786205667 GRCh38 Chromosome 1, 172441964: 172441964
7 DNAH14 NM_001373.1(DNAH14): c.3755T> A (p.Met1252Lys) single nucleotide variant Benign rs786205668 GRCh37 Chromosome 1, 225288474: 225288474
8 DNAH14 NM_001373.1(DNAH14): c.3755T> A (p.Met1252Lys) single nucleotide variant Benign rs786205668 GRCh38 Chromosome 1, 225100772: 225100772
9 NEB NM_001164507.1(NEB): c.21076C> T (p.Arg7026Ter) single nucleotide variant Likely pathogenic rs769345284 GRCh37 Chromosome 2, 152394412: 152394412
10 NEB NM_001164507.1(NEB): c.21076C> T (p.Arg7026Ter) single nucleotide variant Likely pathogenic rs769345284 GRCh38 Chromosome 2, 151537898: 151537898
11 CHRNA1 NM_001039523.2(CHRNA1): c.762C> T (p.Arg254=) single nucleotide variant Likely pathogenic rs545520806 GRCh37 Chromosome 2, 175618322: 175618322
12 CHRNA1 NM_001039523.2(CHRNA1): c.762C> T (p.Arg254=) single nucleotide variant Likely pathogenic rs545520806 GRCh38 Chromosome 2, 174753594: 174753594
13 GALNT14 NM_024572.3(GALNT14): c.1273C> T (p.Arg425Ter) single nucleotide variant Likely pathogenic rs201118996 GRCh37 Chromosome 2, 31147092: 31147092
14 GALNT14 NM_024572.3(GALNT14): c.1273C> T (p.Arg425Ter) single nucleotide variant Likely pathogenic rs201118996 GRCh38 Chromosome 2, 30924226: 30924226
15 GUSB NM_000181.3(GUSB): c.1586A> G (p.Tyr529Cys) single nucleotide variant Likely pathogenic rs786205674 GRCh37 Chromosome 7, 65432785: 65432785
16 GUSB NM_000181.3(GUSB): c.1586A> G (p.Tyr529Cys) single nucleotide variant Likely pathogenic rs786205674 GRCh38 Chromosome 7, 65967798: 65967798
17 GUSB NM_000181.3(GUSB): c.398G> C (p.Trp133Ser) single nucleotide variant Likely pathogenic rs786205671 GRCh38 Chromosome 7, 65979910: 65979910
18 GUSB NM_000181.3(GUSB): c.398G> C (p.Trp133Ser) single nucleotide variant Likely pathogenic rs786205671 GRCh37 Chromosome 7, 65444897: 65444897
19 GUSB NM_000181.3(GUSB): c.307C> T (p.Arg103Trp) single nucleotide variant Likely pathogenic rs786205673 GRCh37 Chromosome 7, 65445300: 65445300
20 GUSB NM_000181.3(GUSB): c.307C> T (p.Arg103Trp) single nucleotide variant Likely pathogenic rs786205673 GRCh38 Chromosome 7, 65980313: 65980313
21 FZD6 NM_001164616.1(FZD6): c.773A> G (p.Tyr258Cys) single nucleotide variant Likely pathogenic rs786205672 GRCh38 Chromosome 8, 103324975: 103324975
22 FZD6 NM_001164616.1(FZD6): c.773A> G (p.Tyr258Cys) single nucleotide variant Likely pathogenic rs786205672 GRCh37 Chromosome 8, 104337203: 104337203
23 THSD1 NM_018676.3(THSD1): c.670C> T (p.Arg224Ter) single nucleotide variant Likely pathogenic rs9536062 GRCh38 Chromosome 13, 52397583: 52397583
24 THSD1 NM_018676.3(THSD1): c.670C> T (p.Arg224Ter) single nucleotide variant Likely pathogenic rs9536062 GRCh37 Chromosome 13, 52971718: 52971718
25 THSD1 NM_018676.3(THSD1): c.617G> A (p.Cys206Tyr) single nucleotide variant Likely pathogenic rs786205669 GRCh37 Chromosome 13, 52971771: 52971771
26 THSD1 NM_018676.3(THSD1): c.617G> A (p.Cys206Tyr) single nucleotide variant Likely pathogenic rs786205669 GRCh38 Chromosome 13, 52397636: 52397636
27 UBN1 NM_001288656.1(UBN1): c.2356T> A (p.Leu786Met) single nucleotide variant Likely pathogenic rs765004815 GRCh38 Chromosome 16, 4874766: 4874766
28 UBN1 NM_001288656.1(UBN1): c.2356T> A (p.Leu786Met) single nucleotide variant Likely pathogenic rs765004815 GRCh37 Chromosome 16, 4924767: 4924767
29 MYOM1 NM_003803.3(MYOM1): c.4987G> A (p.Val1663Met) single nucleotide variant Likely pathogenic rs751200138 GRCh37 Chromosome 18, 3067331: 3067331
30 MYOM1 NM_003803.3(MYOM1): c.4987G> A (p.Val1663Met) single nucleotide variant Likely pathogenic rs751200138 GRCh38 Chromosome 18, 3067333: 3067333
31 CTSA NM_000308.3(CTSA): c.649delC (p.Leu217Phefs) deletion Likely pathogenic rs786205670 GRCh37 Chromosome 20, 44521514: 44521514
32 CTSA NM_000308.3(CTSA): c.649delC (p.Leu217Phefs) deletion Likely pathogenic rs786205670 GRCh38 Chromosome 20, 45892875: 45892875
33 NEU1 NM_000434.3(NEU1): c.1170C> G (p.Tyr390Ter) single nucleotide variant Pathogenic rs746607723 GRCh37 Chromosome 6, 31827574: 31827574
34 NEU1 NM_000434.3(NEU1): c.1170C> G (p.Tyr390Ter) single nucleotide variant Pathogenic rs746607723 GRCh38 Chromosome 6, 31859797: 31859797
35 NEU1 NM_000434.3(NEU1): c.353-2A> G single nucleotide variant Pathogenic rs864309513 GRCh37 Chromosome 6, 31829229: 31829229
36 NEU1 NM_000434.3(NEU1): c.353-2A> G single nucleotide variant Pathogenic rs864309513 GRCh38 Chromosome 6, 31861452: 31861452
37 FLVCR2 GRCh37/hg19 14q24.3(chr14: 76105695-76107636) copy number loss Uncertain significance GRCh37 Chromosome 14, 76105695: 76107636

Expression for Hydrops Fetalis, Nonimmune

Search GEO for disease gene expression data for Hydrops Fetalis, Nonimmune.

Pathways for Hydrops Fetalis, Nonimmune

GO Terms for Hydrops Fetalis, Nonimmune

Cellular components related to Hydrops Fetalis, Nonimmune according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.67 EPHB4 HBA1 HBA2 NEU1
2 extracellular region GO:0005576 9.62 EPHB4 HBA1 HBA2 NEU1
3 blood microparticle GO:0072562 9.4 HBA1 HBA2
4 cytosolic small ribosomal subunit GO:0022627 9.26 HBA1 HBA2
5 endocytic vesicle lumen GO:0071682 9.16 HBA1 HBA2
6 hemoglobin complex GO:0005833 8.96 HBA1 HBA2
7 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA1 HBA2

Biological processes related to Hydrops Fetalis, Nonimmune according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.43 HBA1 HBA2
2 cellular oxidant detoxification GO:0098869 9.4 HBA1 HBA2
3 protein heterooligomerization GO:0051291 9.37 HBA1 HBA2
4 response to hydrogen peroxide GO:0042542 9.32 HBA1 HBA2
5 positive regulation of cell death GO:0010942 9.26 HBA1 HBA2
6 bicarbonate transport GO:0015701 9.16 HBA1 HBA2
7 hydrogen peroxide catabolic process GO:0042744 8.96 HBA1 HBA2
8 oxygen transport GO:0015671 8.62 HBA1 HBA2

Molecular functions related to Hydrops Fetalis, Nonimmune according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.37 HBA1 HBA2
2 heme binding GO:0020037 9.32 HBA1 HBA2
3 oxygen binding GO:0019825 9.26 HBA1 HBA2
4 peroxidase activity GO:0004601 9.16 HBA1 HBA2
5 oxygen carrier activity GO:0005344 8.96 HBA1 HBA2
6 haptoglobin binding GO:0031720 8.62 HBA1 HBA2

Sources for Hydrops Fetalis, Nonimmune

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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