MCID: HYP144
MIFTS: 23

Hyperacusis

Categories: Ear diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Hyperacusis

MalaCards integrated aliases for Hyperacusis:

Name: Hyperacusis 20
Low Tolerance to Sound 20

Classifications:



Summaries for Hyperacusis

GARD : 20 Hyperacusis is a hearing disorder that results in difficulty tolerating sounds that would not bother most people. This condition may occur due to many different causes, such as head injury, viral infections, or neurological disorders. In some people with hyperacusis, sounds are perceived as being much louder than they would be by someone without this disorder. Some people may have emotional reactions to sounds, such as being annoyed or afraid. Others experience pain with low-level sounds. People with hyperacusis can have only one or different combinations of these symptoms. Another very common symptom is ringing in the ears ( tinnitus ). Patients with hyperacusis typically first receive an otolaryngologic exam and hearing testing. These tests can be done by an Audiologist or an Otolaryngologist (ear, nose, and throat doctor). Treatment may involve a program of sound therapy to train the brain to better process everyday sounds. This type of treatment involves listening to low-level white noise to gradually improve the ability to hear sounds.

MalaCards based summary : Hyperacusis, also known as low tolerance to sound, is related to superior semicircular canal dehiscence and bell's palsy. An important gene associated with Hyperacusis is PDLIM1 (PDZ And LIM Domain 1). The drugs Diclofenac and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include cortex, amygdala and eye.

Wikipedia : 73 Hyperacusis is a very rare and highly debilitating hearing disorder characterized by an increased... more...

Related Diseases for Hyperacusis

Diseases related to Hyperacusis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 superior semicircular canal dehiscence 11.0
2 bell's palsy 11.0
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
4 williams-beuren syndrome 10.3
5 allergic disease 10.3
6 otitis media 10.2
7 misophonia 10.2
8 hearing loss, noise-induced 10.1
9 autism spectrum disorder 10.1
10 sensorineural hearing loss 10.1
11 generalized anxiety disorder 10.1
12 facial paralysis 10.1
13 migraine with or without aura 1 10.0
14 autism 10.0
15 branchiootic syndrome 1 10.0
16 otosclerosis 10.0
17 attention deficit-hyperactivity disorder 9.9
18 anxiety 9.9
19 drug-induced hearing loss 9.9
20 disease of mental health 9.9
21 complex regional pain syndrome 9.9
22 fibromyalgia 9.9
23 age-related hearing loss 9.9
24 chronic pain 9.9
25 head injury 9.9
26 creutzfeldt-jakob disease 9.8
27 multiple sclerosis 9.8
28 neural tube defects 9.8
29 down syndrome 9.8
30 vitiligo-associated multiple autoimmune disease susceptibility 6 9.8
31 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
32 myasthenia gravis 9.8
33 abnormal hair, joint laxity, and developmental delay 9.8
34 arts syndrome 9.8
35 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8
36 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
37 ifap syndrome 2 9.8
38 b-lymphoblastic leukemia/lymphoma 9.8
39 adhesive otitis media 9.8
40 social phobia 9.8
41 lyme disease 9.8
42 dementia 9.8
43 uveitis 9.8
44 multiple chemical sensitivity 9.8
45 sleep disorder 9.8
46 dystonia 9.8
47 cochlear disease 9.8
48 panic disorder 9.8
49 chronic fatigue syndrome 9.8
50 pathologic nystagmus 9.8

Graphical network of the top 20 diseases related to Hyperacusis:



Diseases related to Hyperacusis

Symptoms & Phenotypes for Hyperacusis

Drugs & Therapeutics for Hyperacusis

Drugs for Hyperacusis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 3 15307-86-5 3033
2 Antirheumatic Agents Phase 3
3 Anti-Inflammatory Agents Phase 3
4 Cyclooxygenase Inhibitors Phase 3
5 Anti-Inflammatory Agents, Non-Steroidal Phase 3
6 Analgesics Phase 3
7 Analgesics, Non-Narcotic Phase 3

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of Use of a Customized Acoustic Stimulus to Reduce the Disturbing Symptoms of Tinnitus and Hyperacusis Unknown status NCT00730834 Phase 4
2 Tinnitus Retraining Therapy Trial Completed NCT01177137 Phase 3
3 Chronic Electrical Stimulation of the Auditory Cortex for Intractable Tinnitus Completed NCT00486577 Phase 2, Phase 3
4 An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack Completed NCT00330850 Phase 3 PRO-513
5 Intervention for Reduced Sound Tolerance Completed NCT00890526 Phase 1
6 Cognitive Behavioral Therapy for Hyperacusis Completed NCT01321814
7 Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs Completed NCT00386880
8 Treatment for Auditory Hyper-Reactivity Behavior in Children With Autism Using Exposure and Response Prevention Principles Completed NCT03206996
9 Evaluation of the Elimination of Tinnitus and Hyperacusis by the ØREBLUE® Method Recruiting NCT04752176
10 Exploratory Study on the Role of Somatic Modulation in Hyperacusis Recruiting NCT04693819
11 Effect of Psychoeducation Upon Exposure to Sounds and Hyperacusis Severity Recruiting NCT04705246
12 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
13 Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus Withdrawn NCT02283216

Search NIH Clinical Center for Hyperacusis

Genetic Tests for Hyperacusis

Anatomical Context for Hyperacusis

MalaCards organs/tissues related to Hyperacusis:

40
Cortex, Amygdala, Eye, Spinal Cord, Endothelial, Brain

Publications for Hyperacusis

Articles related to Hyperacusis:

(show top 50) (show all 603)
# Title Authors PMID Year
1
Impact of abuse on migraine-related sensory hypersensitivity symptoms: Results from the American Registry for Migraine Research. 61
33779989 2021
2
Abnormal auditory event-related potentials in Williams syndrome. 61
33571693 2021
3
Hyperacusis in tinnitus patients relates to enlarged subcortical and cortical responses to sound except at the tinnitus frequency. 61
33421659 2021
4
Cut-off score of the Khalfa Hyperacusis Questionnaire with 10 selected items. 61
33733977 2021
5
Effects of Age on Loudness-Dependent Auditory ERPs in Young Autistic and Typically-Developing Children. 61
33781752 2021
6
A psychoacoustic test for diagnosing hyperacusis based on ratings of natural sounds. 61
33321385 2021
7
The Source of Hemisensory Disturbances in Complex Regional Pain Syndrome. 61
33136610 2021
8
Olivocochlear efferent effects on perception and behavior. 61
33674070 2021
9
[Analysis of clinical characteristics of 87 patients with cochlear migraine]. 61
33540990 2021
10
Development of ebselen for the treatment of sensorineural hearing loss and tinnitus. 61
33678494 2021
11
A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms. 61
33285160 2021
12
Prevalence of Decreased Sound Tolerance (Hyperacusis) in Individuals With Autism Spectrum Disorder: A Meta-Analysis. 61
33577214 2021
13
[Superior semicircular canal dehiscence syndrome]. 61
33491628 2021
14
Separate auditory pathways for the induction and maintenance of tinnitus and hyperacusis? 61
33637214 2021
15
Superior semicircular canal dehiscence syndrome: Diagnostic criteria consensus document of the committee for the classification of vestibular disorders of the bárány society. 61
33522990 2021
16
Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity. 61
33465315 2021
17
Hyperacusis and stapes surgery: An observation in fifty patients after stapedotomy. 61
33505445 2021
18
The ototoxic potential of cobalt from metal-on-metal hip implants: a pilot study on the patient-reported auditory, vestibular, and general neurological outcome. 61
32687006 2021
19
Decreased Sound Tolerance in Tinnitus Patients. 61
33530474 2021
20
Preliminary Examination of the Incidence of and Factors Related to Hearing Tinnitus in Dreams. 61
33296927 2020
21
Development and validation of Hyperacusis Handicap Questionnaire in individuals with tinnitus associated with hyperacusis. 61
33293911 2020
22
A Delphi survey to determine a definition and description of hyperacusis by clinician consensus. 61
33305628 2020
23
Misophonia: An Evidence-Based Case Report. 61
32955918 2020
24
Auditory Quality-of-Life Measures in Patients With Traumatic Brain Injury and Normal Pure Tone Audiometry. 61
32600124 2020
25
Occupational Noise: Auditory and Non-Auditory Consequences. 61
33276507 2020
26
Tinnitus and hyperacusis: Central noise, gain and variance. 61
33299958 2020
27
Checklist for the initial evaluation of oral and maxillofacial trauma. 61
33270348 2020
28
Acoustic Reflexes in Individuals Having Hyperacusis of the Auditory Origin. 61
33088781 2020
29
Ventral cochlear nucleus bushy cells encode hyperacusis in guinea pigs. 61
33244141 2020
30
The effect of insular cortex lesion on hyperacusis-like behavior in rats. 61
32003272 2020
31
Internal Consistency and Convergent Validity of the Inventory of Hyperacusis Symptoms. 61
33259445 2020
32
Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism. 61
33024221 2020
33
The Content and Quality of Information About Hyperacusis Presented Online. 61
32946248 2020
34
Complaints of People with Hyperacusis. 61
32340056 2020
35
Focal Unilateral Palatal Myoclonus Causing Objective Clicking Tinnitus without Uvula Elevation Diagnosed by Concurrent Auscultation. 61
32654474 2020
36
Investigating the effects of noise exposure on self-report, behavioral and electrophysiological indices of hearing damage in musicians with normal audiometric thresholds. 61
32631495 2020
37
Facial Nerve Palsy: Clinical Practice and Cognitive Errors. 61
32445717 2020
38
Spinal cord injury in the United States Army Special Forces. 61
32977307 2020
39
Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media. 61
32333137 2020
40
The Role of Anti-Endothelial Cell Autoantibodies and Immune Response in Acute Low-Tone Hearing Loss. 61
32865463 2020
41
Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling. 61
32554129 2020
42
Readability assessment of self-report hyperacusis questionnaires. 61
32134337 2020
43
How low must you go? Effects of low-level noise on cochlear neural response. 61
32447098 2020
44
Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis. 61
32653998 2020
45
Association between Hyperacusis and Tinnitus. 61
32731492 2020
46
Hyperacusis in children: a scoping review. 61
32600446 2020
47
Development of novel in silico prediction model for drug-induced ototoxicity by using naïve Bayes classifier approach. 61
32109528 2020
48
Pulsatile tinnitus caused by pneumocephalus after Janneta surgery. 61
32586740 2020
49
Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients. 61
31786960 2020
50
Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine. 61
32295535 2020

Variations for Hyperacusis

Expression for Hyperacusis

Search GEO for disease gene expression data for Hyperacusis.

Pathways for Hyperacusis

GO Terms for Hyperacusis

Sources for Hyperacusis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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