MCID: HYP144
MIFTS: 27

Hyperacusis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Hyperacusis

MalaCards integrated aliases for Hyperacusis:

Name: Hyperacusis 54 30
Low Tolerance to Sound 54

Classifications:



Summaries for Hyperacusis

NIH Rare Diseases : 54 Hyperacusis is a hearing disorder that results in difficulty tolerating sounds that would not bother most people. This condition may occur due to many different causes, such as head injury, viral infections, or neurological disorders. In some people with hyperacusis, sounds are perceived as being much louder than they would be by someone without this disorder. Some people may have emotional reactions to sounds, such as being annoyed or afraid. Others experience pain with low-level sounds. People with hyperacusis can have only one or different combinations of these symptoms. Another very common symptom is ringing in the ears (tinnitus). Patients with hyperacusis typically first receive an otolaryngologic exam and hearing testing. These tests can be done by an Audiologist or an Otolaryngologist (ear, nose, and throat doctor). Treatment may involve a program of sound therapy to train the brain to better process everyday sounds. This type of treatment involves ing to low-level white noise to gradually improve the ability to hear sounds.

MalaCards based summary : Hyperacusis, also known as low tolerance to sound, is related to superior semicircular canal dehiscence and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. An important gene associated with Hyperacusis is PDLIM1 (PDZ And LIM Domain 1). The drugs Diclofenac and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and cortex.

Wikipedia : 77 Hyperacusis is a highly debilitating hearing disorder characterized by an increased sensitivity to... more...

Related Diseases for Hyperacusis

Graphical network of the top 20 diseases related to Hyperacusis:



Diseases related to Hyperacusis

Symptoms & Phenotypes for Hyperacusis

Drugs & Therapeutics for Hyperacusis

Drugs for Hyperacusis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 3 15307-86-5 3033
2 Peripheral Nervous System Agents Phase 3
3 Anti-Inflammatory Agents Phase 3
4 Cyclooxygenase Inhibitors Phase 3
5 Anti-Inflammatory Agents, Non-Steroidal Phase 3
6 Analgesics Phase 3
7 Antirheumatic Agents Phase 3
8 Analgesics, Non-Narcotic Phase 3
9
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
10
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 439302 53477758
11
Coenzyme Q10 Approved, Investigational, Nutraceutical Not Applicable 303-98-0 5281915
12 Ubiquinone Not Applicable
13 Vasopressins Not Applicable
14 arginine Not Applicable
15 Arginine Vasopressin Not Applicable
16 Psychotropic Drugs Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis Unknown status NCT00730834 Phase 4
2 Chronic Electrical Stimulation of the Auditory Cortex for Intractable Tinnitus Completed NCT00486577 Phase 2, Phase 3
3 Safety and Efficacy in Adult Subjects With Acute Migraines Completed NCT03237845 Phase 3 Rimegepant;Placebo
4 Safety and Efficacy Study in Adult Subjects With Acute Migraines Completed NCT03235479 Phase 3 BHV-3000;Placebo Oral Tablet
5 An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack Completed NCT00330850 Phase 3 PRO-513
6 Tinnitus Retraining Therapy Trial Completed NCT01177137 Phase 3
7 Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI) Completed NCT02367521 Phase 2, Phase 3
8 Conventional Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment Completed NCT01407133 Phase 1, Phase 2
9 Intervention for Reduced Sound Tolerance Completed NCT00890526 Phase 1
10 Effect of Time Shift of Transcranial Direct Current Stimulation (tDCS) for Treatment of Acute Tinnitus Unknown status NCT01886729 Not Applicable
11 The Effect of Coenzyme Q10 on Hearing and Tinnitus Characteristics of Chronic Tinnitus Patients Unknown status NCT02353650 Not Applicable
12 Cognitive Behavioral Therapy for Hyperacusis Completed NCT01321814 Not Applicable
13 The Effect of Transcranial Direct Current Stimulation (tDCS) in Addition to Tinnitus Retraining Therapy (TRT) for Treatment of Chronic Tinnitus Patients Completed NCT02285803 Not Applicable
14 Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs Completed NCT00386880
15 Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus Completed NCT02283216 Not Applicable
16 rTMS for the Treatment of Chronic Tinnitus: Optimization by Simulation of the Cortical Tinnitus Network Completed NCT01663324 Not Applicable
17 Audiovisual Assessment After Dural Puncture During Epidural Placement in Obstetric Patients Completed NCT03428841
18 Exposure Therapy for Auditory Sensitivity in Autism Recruiting NCT03206996 Not Applicable
19 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
20 Temporomandibular Dysfunction in Patients With Tinnitus: Assessment and Treatment Recruiting NCT03209297 Not Applicable
21 A Randomized Controlled HD-tDCS Trial: Effects on Tinnitus Severity and Cognition Recruiting NCT03754127 Not Applicable
22 Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory Recruiting NCT03101826 Not Applicable
23 The Value of EMDR in the Treatment of Tinnitus Recruiting NCT03114878 Not Applicable
24 A Natural History Study of the Gangliosidoses Recruiting NCT00668187
25 A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom Active, not recruiting NCT02370810 Not Applicable
26 Internet-based Versus Face-to-face Clinical Care for Tinnitus Active, not recruiting NCT02665975 Not Applicable
27 Home-based SSP on Individuals With PWS Not yet recruiting NCT03871751 Not Applicable
28 Variability of Tinnitus Characterization Tools and Investigation of Audiovisual Integration in Tinnitus Perception Withdrawn NCT02717065 Not Applicable

Search NIH Clinical Center for Hyperacusis

Genetic Tests for Hyperacusis

Genetic tests related to Hyperacusis:

# Genetic test Affiliating Genes
1 Hyperacusis 30

Anatomical Context for Hyperacusis

MalaCards organs/tissues related to Hyperacusis:

42
Testes, Brain, Cortex, Skin

Publications for Hyperacusis

Articles related to Hyperacusis:

(show top 50) (show all 175)
# Title Authors Year
1
Associations between hyperacusis and psychosocial work factors in the general population. ( 30194539 )
2019
2
Top ten hyperacusis research priorities in the UK. ( 30722956 )
2019
3
Voluntary increase of acoustic middle ear impedances with simultaneous sound attenuation associated with mild hyperacusis (VIMH). ( 30806127 )
2019
4
Overview: Hearing Loss, Tinnitus, Hyperacusis, and the role of Central Gain. ( 30885639 )
2019
5
Hyperacusis in children: A clinical profile. ( 29501317 )
2018
6
Psychometric Properties and Factor Structure of a New Scale to Measure Hyperacusis: Introducing the Inventory of Hyperacusis Symptoms. ( 29742543 )
2018
7
Proportion and characteristics of patients who were offered, enrolled in and completed audiologist-delivered cognitive behavioural therapy for tinnitus and hyperacusis rehabilitation in a specialist UK clinic. ( 29415588 )
2018
8
Sensitivity to sounds in sport-related concussed athletes: a new clinical presentation of hyperacusis. ( 29967340 )
2018
9
Uncomfortable loudness levels among children and adolescents seeking help for tinnitus and/or hyperacusis. ( 29688102 )
2018
10
Hyperacusis: major research questions. ( 29392341 )
2018
11
One-Year Results for Patients with Unilateral Hearing Loss and Accompanying Severe Tinnitus and Hyperacusis Treated with a Cochlear Implant. ( 29929187 )
2018
12
Prolonged Exposure of CBA/Ca Mice to Moderately Loud Noise Can Cause Cochlear Synaptopathy but Not Tinnitus or Hyperacusis as Assessed With the Acoustic Startle Reflex. ( 29532738 )
2018
13
Thoughts about Suicide and Self-Harm in Patients with Tinnitus and Hyperacusis. ( 29488875 )
2018
14
Long-Term Effects of Middle Ear Tendon Resection on Middle Ear Myoclonic Tinnitus, Hearing, and Hyperacusis. ( 29649793 )
2018
15
Effect of sound generator on tinnitus and hyperacusis. ( 29043888 )
2018
16
Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects. ( 29370266 )
2018
17
Parental Mental Health in Childhood as a Risk Factor for Anxiety and Depression among People Seeking Help for Tinnitus and Hyperacusis. ( 30446035 )
2018
18
Prevalence and Characteristics of Patients with Severe Hyperacusis among Patients Seen in a Tinnitus and Hyperacusis Clinic. ( 29988010 )
2018
19
Hyperacusis in Children: A Preliminary Study on the Effects of Hypersensitivity to Sound on Speech and Language. ( 29993211 )
2018
20
Hyperacusis in children: The Edinburgh experience. ( 30055737 )
2018
21
Insights from the third international conference on hyperacusis: causes, evaluation, diagnosis, and treatment. ( 30136676 )
2018
22
Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and Hyperacusis Rehabilitation: Outcomes for Patients Treated in Routine Practice. ( 30242355 )
2018
23
Rationale and Efficacy of Sound Therapies for Tinnitus and Hyperacusis. ( 30244031 )
2018
24
Hearing Loss, Tinnitus, Hyperacusis, and Diplacusis in Professional Musicians: A Systematic Review. ( 30261653 )
2018
25
Hyperacusis and disorders of sound intolerance. ( 30261767 )
2018
26
Parental separation and parental mental health in childhood and tinnitus and hyperacusis disability in adulthood: a retrospective exploratory analysis. ( 30272507 )
2018
27
Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis. ( 30292765 )
2018
28
The Relationship between Severity of Hearing Loss and Subjective Tinnitus Loudness among Patients Seen in a Specialist Tinnitus and Hyperacusis Therapy Clinic in UK. ( 30403955 )
2018
29
Stapes hypermobility as a possible cause of hyperacusis. ( 30502003 )
2018
30
Enhanced Central Neural Gain Compensates Acoustic Trauma-induced Cochlear Impairment, but Unlikely Correlates with Tinnitus and Hyperacusis. ( 30599268 )
2018
31
Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic. ( 28622055 )
2017
32
Incidence of Discomfort During Pure-Tone Audiometry and Measurement of Uncomfortable Loudness Levels Among People Seeking Help for Tinnitus and/or Hyperacusis. ( 28810267 )
2017
33
Assessment of Reduced Tolerance to Sound (Hyperacusis) in University Students. ( 29192616 )
2017
34
Increased Hyperacusis with Risperidone in an Autistic Child. ( 28680319 )
2017
35
The short hyperacusis questionnaire: A tool for the identification and measurement of hyperacusis in the Italian tinnitus population. ( 29071058 )
2017
36
Effects of the cannabinoid CB<sub>1</sub>agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs. ( 29108871 )
2017
37
Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity. ( 27838888 )
2017
38
Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects. ( 28463806 )
2017
39
Health-relevant personality is associated with sensitivity to sound (hyperacusis). ( 28252196 )
2017
40
Hyperacusis in chronic pain: neural interactions between the auditory and nociceptive systems. ( 28685627 )
2017
41
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress. ( 28286099 )
2017
42
Factors Associated With Depression in Patients With Tinnitus and Hyperacusis. ( 29209701 )
2017
43
Clinical Interventions for Hyperacusis in Adults: A Scoping Review to Assess the Current Position and Determine Priorities for Research. ( 29312994 )
2017
44
Characteristics of somatic tinnitus patients with and without hyperacusis. ( 29161302 )
2017
45
Usefulness of self-report questionnaires for psychological assessment of patients with tinnitus and hyperacusis and patients' views of the questionnaires. ( 28277857 )
2017
46
Factors related to tinnitus and hyperacusis handicap in older people. ( 28625091 )
2017
47
Efferent inhibition strength is a physiological correlate of hyperacusis in children with autism spectrum disorder. ( 28592687 )
2017
48
Assessment of hyperacusis with a newly produced Japanese version of the Khalfa hyperacusis questionnaire. ( 28394666 )
2017
49
Prevalence of tinnitus and hyperacusis in children and adolescents: a systematic review. ( 27259524 )
2016
50
Severe Hyperacusis, Photophobia, and Skin Hypersensitivity. ( 26981300 )
2016

Variations for Hyperacusis

Expression for Hyperacusis

Search GEO for disease gene expression data for Hyperacusis.

Pathways for Hyperacusis

GO Terms for Hyperacusis

Sources for Hyperacusis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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