Aliases & Classifications for Hyperacusis

MalaCards integrated aliases for Hyperacusis:

Name: Hyperacusis 53 29
Low Tolerance to Sound 53

Classifications:



Summaries for Hyperacusis

NIH Rare Diseases : 53 Hyperacusis is a hearing disorder that results in difficulty tolerating sounds that would not bother most people. This condition may occur due to many different causes, such as head injury, viral infections, or neurological disorders. In some people with hyperacusis, sounds are perceived as being much louder than they would be by someone without this disorder. Some people may have emotional reactions to sounds, such as being annoyed or afraid. Others experience pain with low-level sounds. People with hyperacusis can have only one or different combinations of these symptoms. Another very common symptom is ringing in the ears (tinnitus). Patients with hyperacusis typically first receive an otolaryngologic exam and hearing testing. These tests can be done by an Audiologist or an Otolaryngologist (ear, nose, and throat doctor). Treatment may involve a program of sound therapy to train the brain to better process everyday sounds. This type of treatment involves ing to low-level white noise to gradually improve the ability to hear sounds.

MalaCards based summary : Hyperacusis, also known as low tolerance to sound, is related to superior semicircular canal dehiscence and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. An important gene associated with Hyperacusis is PDLIM1 (PDZ And LIM Domain 1). The drugs Diclofenac and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and cortex.

Wikipedia : 76 Hyperacusis (or hyperacousis) is a debilitating hearing disorder characterized by an increased... more...

Related Diseases for Hyperacusis

Graphical network of the top 20 diseases related to Hyperacusis:



Diseases related to Hyperacusis

Symptoms & Phenotypes for Hyperacusis

Drugs & Therapeutics for Hyperacusis

Drugs for Hyperacusis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 3 15307-86-5 3033
2 Analgesics Phase 3
3 Cyclooxygenase Inhibitors Phase 3
4 Analgesics, Non-Narcotic Phase 3
5 Peripheral Nervous System Agents Phase 3
6 Anti-Inflammatory Agents Phase 3
7 Anti-Inflammatory Agents, Non-Steroidal Phase 3
8 Antirheumatic Agents Phase 3
9
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
10
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 439302 53477758
11
Coenzyme Q10 Approved, Investigational, Nutraceutical Not Applicable 303-98-0 5281915
12 Ubiquinone Not Applicable
13 Vasopressins Not Applicable
14 Psychotropic Drugs Not Applicable
15 Arginine Vasopressin Not Applicable
16 arginine Nutraceutical Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis Unknown status NCT00730834 Phase 4
2 Chronic Electrical Stimulation of the Auditory Cortex for Intractable Tinnitus Completed NCT00486577 Phase 2, Phase 3
3 Safety and Efficacy in Adult Subjects With Acute Migraines Completed NCT03237845 Phase 3 Rimegepant;Placebo
4 Safety and Efficacy Study in Adult Subjects With Acute Migraines Completed NCT03235479 Phase 3 BHV-3000;Placebo Oral Tablet
5 An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack Completed NCT00330850 Phase 3 PRO-513
6 Tinnitus Retraining Therapy Trial Completed NCT01177137 Phase 3
7 Conventional Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment Completed NCT01407133 Phase 1, Phase 2
8 Intervention for Reduced Sound Tolerance Completed NCT00890526 Phase 1
9 Effect of Time Shift of Transcranial Direct Current Stimulation (tDCS) for Treatment of Acute Tinnitus Unknown status NCT01886729 Not Applicable
10 The Effect of Coenzyme Q10 on Hearing and Tinnitus Characteristics of Chronic Tinnitus Patients Unknown status NCT02353650 Not Applicable
11 Cognitive Behavioral Therapy for Hyperacusis Completed NCT01321814 Not Applicable
12 The Effect of Transcranial Direct Current Stimulation (tDCS) in Addition to Tinnitus Retraining Therapy (TRT) for Treatment of Chronic Tinnitus Patients Completed NCT02285803 Not Applicable
13 Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs Completed NCT00386880
14 Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus Completed NCT02283216 Not Applicable
15 rTMS for the Treatment of Chronic Tinnitus: Optimization by Simulation of the Cortical Tinnitus Network Completed NCT01663324 Not Applicable
16 Audiovisual Assessment After Dural Puncture During Epidural Placement in Obstetric Patients Completed NCT03428841
17 Exposure Therapy for Auditory Sensitivity in Autism Recruiting NCT03206996 Not Applicable
18 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
19 Temporomandibular Dysfunction in Patients With Tinnitus: Assessment and Treatment Recruiting NCT03209297 Not Applicable
20 Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory Recruiting NCT03101826 Not Applicable
21 The Value of EMDR in the Treatment of Tinnitus Recruiting NCT03114878 Not Applicable
22 A Natural History Study of the Gangliosidoses Recruiting NCT00668187
23 A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom Active, not recruiting NCT02370810 Not Applicable
24 Internet-based Versus Face-to-face Clinical Care for Tinnitus Active, not recruiting NCT02665975 Not Applicable
25 Variability of Tinnitus Characterization Tools and Investigation of Audiovisual Integration in Tinnitus Perception Withdrawn NCT02717065 Not Applicable

Search NIH Clinical Center for Hyperacusis

Genetic Tests for Hyperacusis

Genetic tests related to Hyperacusis:

# Genetic test Affiliating Genes
1 Hyperacusis 29

Anatomical Context for Hyperacusis

MalaCards organs/tissues related to Hyperacusis:

41
Testes, Brain, Cortex, Skin

Publications for Hyperacusis

Articles related to Hyperacusis:

(show top 50) (show all 153)
# Title Authors Year
1
Hyperacusis in children: A clinical profile. ( 29501317 )
2018
2
Psychometric Properties and Factor Structure of a New Scale to Measure Hyperacusis: Introducing the Inventory of Hyperacusis Symptoms. ( 29742543 )
2018
3
Proportion and characteristics of patients who were offered, enrolled in and completed audiologist-delivered cognitive behavioural therapy for tinnitus and hyperacusis rehabilitation in a specialist UK clinic. ( 29415588 )
2018
4
Sensitivity to sounds in sport-related concussed athletes: a new clinical presentation of hyperacusis. ( 29967340 )
2018
5
Uncomfortable loudness levels among children and adolescents seeking help for tinnitus and/or hyperacusis. ( 29688102 )
2018
6
Hyperacusis: major research questions. ( 29392341 )
2018
7
One-Year Results for Patients with Unilateral Hearing Loss and Accompanying Severe Tinnitus and Hyperacusis Treated with a Cochlear Implant. ( 29929187 )
2018
8
Prolonged Exposure of CBA/Ca Mice to Moderately Loud Noise Can Cause Cochlear Synaptopathy but Not Tinnitus or Hyperacusis as Assessed With the Acoustic Startle Reflex. ( 29532738 )
2018
9
Thoughts about Suicide and Self-Harm in Patients with Tinnitus and Hyperacusis. ( 29488875 )
2018
10
Long-Term Effects of Middle Ear Tendon Resection on Middle Ear Myoclonic Tinnitus, Hearing, and Hyperacusis. ( 29649793 )
2018
11
Effect of sound generator on tinnitus and hyperacusis. ( 29043888 )
2018
12
Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects. ( 29370266 )
2018
13
Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic. ( 28622055 )
2017
14
Incidence of Discomfort During Pure-Tone Audiometry and Measurement of Uncomfortable Loudness Levels Among People Seeking Help for Tinnitus and/or Hyperacusis. ( 28810267 )
2017
15
Assessment of Reduced Tolerance to Sound (Hyperacusis) in University Students. ( 29192616 )
2017
16
Increased Hyperacusis with Risperidone in an Autistic Child. ( 28680319 )
2017
17
The short hyperacusis questionnaire: A tool for the identification and measurement of hyperacusis in the Italian tinnitus population. ( 29071058 )
2017
18
Effects of the cannabinoid CB<sub>1</sub>agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs. ( 29108871 )
2017
19
Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity. ( 27838888 )
2017
20
Salicylate-induced hyperacusis in rats: Dose- and frequency-dependent effects. ( 28463806 )
2017
21
Health-relevant personality is associated with sensitivity to sound (hyperacusis). ( 28252196 )
2017
22
Hyperacusis in chronic pain: neural interactions between the auditory and nociceptive systems. ( 28685627 )
2017
23
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress. ( 28286099 )
2017
24
Factors Associated With Depression in Patients With Tinnitus and Hyperacusis. ( 29209701 )
2017
25
Clinical Interventions for Hyperacusis in Adults: A Scoping Review to Assess the Current Position and Determine Priorities for Research. ( 29312994 )
2017
26
Characteristics of somatic tinnitus patients with and without hyperacusis. ( 29161302 )
2017
27
Usefulness of self-report questionnaires for psychological assessment of patients with tinnitus and hyperacusis and patients' views of the questionnaires. ( 28277857 )
2017
28
Factors related to tinnitus and hyperacusis handicap in older people. ( 28625091 )
2017
29
Efferent inhibition strength is a physiological correlate of hyperacusis in children with autism spectrum disorder. ( 28592687 )
2017
30
Assessment of hyperacusis with a newly produced Japanese version of the Khalfa hyperacusis questionnaire. ( 28394666 )
2017
31
Prevalence of tinnitus and hyperacusis in children and adolescents: a systematic review. ( 27259524 )
2016
32
Severe Hyperacusis, Photophobia, and Skin Hypersensitivity. ( 26981300 )
2016
33
Scrub typhus with hyperacusis and tinnitus. ( 27728719 )
2016
34
Effects of noise exposure on development of tinnitus and hyperacusis: Prevalence rates 12 months after exposure in middle-aged rats. ( 26584761 )
2016
35
Management of hyperacusis in children - two case reports. ( 27133908 )
2016
36
Characteristics of hyperacusis in the general population. ( 27569405 )
2016
37
Early age noise exposure increases loudness perception - A novel animal model of hyperacusis. ( 27746216 )
2016
38
Minimally Invasive Surgery for the Treatment of Hyperacusis. ( 27668792 )
2016
39
Coexistence of tinnitus and hyperacusis in individuals with auditory dys-synchrony: A single case study. ( 26989651 )
2016
40
Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments. ( 27195947 )
2016
41
Speech Comprehension Difficulties in Chronic Tinnitus and Its Relation to Hyperacusis. ( 28018209 )
2016
42
Elevated Acoustic Startle Responses in Humans: Relationship to Reduced Loudness Discomfort Level, but not Self-Report of Hyperacusis. ( 26931342 )
2016
43
Prevalence and risk factors for reduced sound tolerance (hyperacusis) in children. ( 26642866 )
2016
44
Demographic data, referral patterns and interventions used for children and adolescents with tinnitus and hyperacusis in Denmark. ( 27619040 )
2016
45
Pathology of Tinnitus and Hyperacusis-Clinical Implications. ( 26587541 )
2015
46
Abnormal Auditory Gain in Hyperacusis: Investigation with a Computational Model. ( 26236277 )
2015
47
Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. ( 25962854 )
2015
48
Decreased sound tolerance: hyperacusis, misophonia, diplacousis, and polyacousis. ( 25726280 )
2015
49
Validation of Screening Questions for Hyperacusis in Chronic Tinnitus. ( 26557654 )
2015
50
Tinnitus and hyperacusis in autism spectrum disorders with emphasis on high functioning individuals diagnosed with Asperger's Syndrome. ( 26243502 )
2015

Variations for Hyperacusis

Expression for Hyperacusis

Search GEO for disease gene expression data for Hyperacusis.

Pathways for Hyperacusis

GO Terms for Hyperacusis

Sources for Hyperacusis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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