MCID: HYP705
MIFTS: 20

Hyperadrenalism

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Hyperadrenalism

MalaCards integrated aliases for Hyperadrenalism:

Name: Hyperadrenalism 53
Adrenal Gland Hyperfunction 53

Classifications:



Summaries for Hyperadrenalism

MalaCards based summary : Hyperadrenalism, also known as adrenal gland hyperfunction, is related to acth-secreting pituitary adenoma and conn's syndrome. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and adrenal gland.

Wikipedia : 76 Cushing''s syndrome is a collection of signs and symptoms due to prolonged exposure to cortisol. Signs... more...

Related Diseases for Hyperadrenalism

Diseases related to Hyperadrenalism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 acth-secreting pituitary adenoma 11.4
2 conn's syndrome 10.1
3 pituitary tumors 10.1
4 hypertension, essential 10.0
5 osteoporosis 10.0
6 pemphigus vulgaris, familial 10.0
7 rheumatoid arthritis 10.0
8 arthritis 10.0
9 pemphigus vulgaris 10.0
10 pemphigus 10.0
11 hypoadrenalism 10.0

Graphical network of the top 20 diseases related to Hyperadrenalism:



Diseases related to Hyperadrenalism

Symptoms & Phenotypes for Hyperadrenalism

Drugs & Therapeutics for Hyperadrenalism

Drugs for Hyperadrenalism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 197)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 329-65-7 838
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-43-4 5816
3
Spironolactone Approved Phase 4,Phase 3,Not Applicable 52-01-7, 1952-01-7 5833
4
Eplerenone Approved Phase 4,Not Applicable 107724-20-9 443872 150310
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
7
Captopril Approved Phase 4 62571-86-2 44093
8
Mifepristone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 84371-65-3 55245
9
Morphine Approved, Investigational Phase 4 57-27-2 5288826
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
12
Losartan Approved Phase 4 114798-26-4 3961
13
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Mydriatics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Epinephryl borate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Sympathomimetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 diuretics Phase 4,Not Applicable
30 Diuretics, Potassium Sparing Phase 4,Not Applicable
31 Mineralocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
32 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Not Applicable
33 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Natriuretic Agents Phase 4,Not Applicable
36 Antiparkinson Agents Phase 4
37 Dopamine agonists Phase 4
38 Dopamine Agents Phase 4
39 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Antihypertensive Agents Phase 4,Phase 3,Not Applicable
41
protease inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
42 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
43 Angiotensin-Converting Enzyme Inhibitors Phase 4
44 Contraceptives, Oral Phase 4,Phase 3,Phase 1,Phase 2
45 Contraceptives, Postcoital Phase 4,Phase 3,Phase 1,Phase 2
46 Luteolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
47 Contraceptive Agents Phase 4,Phase 3,Phase 1,Phase 2
48 Entonox Phase 4
49 Central Nervous System Depressants Phase 4,Not Applicable
50 Analgesics, Opioid Phase 4

Interventional clinical trials:

(show top 50) (show all 176)
# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 Does Aldosterone Cause Hypertension by a Non-Renal Mechanism? Unknown status NCT00553722 Phase 4 Eplerenone;Placebo
3 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
4 Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism Completed NCT01990560 Phase 4 Mifepristone
5 Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia. Completed NCT02198378 Phase 4 MEOPA and paracetamol;Morphine
6 Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism Completed NCT00155064 Phase 4 captopril, Losartan (drug)
7 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
8 Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment Recruiting NCT03760835 Phase 4 Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone);Dual release hydrocortisone (plenadren)
9 Prevention of Metabolic Complications of Glucocorticoid Excess Unknown status NCT01319994 Phase 2, Phase 3 Metformin;Placebo
10 COrticosteroid in Congenital Adrenal Hyperplasia Unknown status NCT02552251 Phase 2, Phase 3
11 Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome Completed NCT01371565 Phase 3 Mifepristone
12 Effects of IL-1 Beta on the HPA-axis in Obese Persons Completed NCT02227420 Phase 3 Anakinra
13 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
14 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
15 Efficacy and Safety of Pasireotide Administered Monthly in Patients With Cushing's Disease Completed NCT01374906 Phase 3 pasireotide LAR;SOM230 LAR 30 mg;SOM230 LAR 10 mg
16 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
17 Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal Hyperplasia Completed NCT02716818 Phase 3 Chronocort®;standard glucocorticoid therapy
18 Treatment for Endogenous Cushing's Syndrome Completed NCT01838551 Phase 3 COR-003
19 The Role of Mineralocorticoid Receptors in Vascular Function Completed NCT00759525 Phase 2, Phase 3 Glycyrrhetic Acid;Placebo
20 A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. Recruiting NCT03277690 Phase 3 Levoketoconazole;Placebo
21 Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome Recruiting NCT02297945 Phase 3 metyrapone
22 A Study of the Efficacy and Safety of Relacorilant Recruiting NCT03697109 Phase 3 Relacorilant
23 A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH Recruiting NCT03062280 Phase 3 Hydrocortisone
24 Adrenal Artery Ablation for Primary Aldosteronism Recruiting NCT03653845 Phase 3 Sequenced antihypertensvie drugs with titrated dosage
25 Adrenal Artery Ablation Treats Primary Aldosteronism Recruiting NCT03398785 Phase 3
26 Open-label Treatment in Cushing's Syndrome Not yet recruiting NCT03621280 Phase 3 Levoketoconazole
27 Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement Therapy Suspended NCT03532022 Phase 3 Chronocort®;Standard Care
28 Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia Unknown status NCT01771328 Phase 2 Hydrocortisone;Cortisone acetate
29 Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia Unknown status NCT02096510 Phase 1, Phase 2 Solu-Cortef;Cortef
30 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Completed NCT02804750 Phase 2 CORT125134
31 Mifepristone for Metabolic Syndrome Completed NCT01419535 Phase 1, Phase 2 Mifepristone
32 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Completed NCT03174171 Phase 2 Everolimus 0.75 mg
33 Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism Completed NCT00732771 Phase 2 LCI699
34 A Study of ATR-101 for the Treatment of Congenital Adrenal Hyperplasia Completed NCT02804178 Phase 2 ATR-101
35 Dexamethasone Treatment of Congenital Adrenal Hyperplasia Completed NCT00621985 Phase 2 dexamethasone;Hydrocortisone
36 Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia Completed NCT00519818 Phase 1, Phase 2 Chronocort;Cortef
37 Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia Completed NCT00001521 Phase 2 Flutamide;Letrozole;Hydrocortisone
38 Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets Completed NCT00000102 Phase 1, Phase 2 Nifedipine
39 Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia Completed NCT01859312 Phase 2 Hydrocortisone (Solucortef)
40 Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH Completed NCT01735617 Phase 2 Hydrocortisone Modified Release Capsules
41 A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease Completed NCT00088608 Phase 2 SOM230 s.c.
42 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Completed NCT02468193 Phase 2 Osilodrostat
43 Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy Completed NCT01867710 Phase 2 Abiraterone Acetate;Prednisone 5 mg twice daily;Prednisone 5 mg once daily;Prednisone 2.5 mg twice daily;Dexamethasone 0.5 mg once daily
44 Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome Recruiting NCT02019706 Phase 2 F-DOPA PET Scan;Mifepristone;Ga-DOTATATE;Octreoscan
45 New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome Recruiting NCT00001849 Phase 1, Phase 2 Pentetreotide;18-F-fluorodeoxyglucose;(18F)-L-3,4-dihydroxyophenylalanine (18F-DOPA)
46 Extension Study to Evaluate the Safety and Clinical Benefit of Long-Term Use of Relacorilant in Patients With Cushing Syndrome Recruiting NCT03604198 Phase 2 relacorilant
47 Study to Evaluate the Safety and Efficacy of SPR001 in Subjects With Classic Congenital Adrenal Hyperplasia Recruiting NCT03687242 Phase 2 SPR001
48 Nevanimibe HCl for the Treatment of Classic CAH Recruiting NCT03669549 Phase 2 Nevanimibe hydrochloride
49 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 in Adults With Congenital Adrenal Hyperplasia Recruiting NCT03525886 Phase 2 NBI-74788
50 Study of SPR001 in Adults With Classic Congenital Adrenal Hyperplasia Recruiting NCT03257462 Phase 2 SPR001

Search NIH Clinical Center for Hyperadrenalism

Genetic Tests for Hyperadrenalism

Anatomical Context for Hyperadrenalism

MalaCards organs/tissues related to Hyperadrenalism:

41
Skin, Bone, Adrenal Gland, Heart, Pituitary, Eye

Publications for Hyperadrenalism

Articles related to Hyperadrenalism:

(show all 14)
# Title Authors Year
1
An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells. ( 30021644 )
2018
2
Letter to the Editor: Including the Zona Reticularis in the Definition of Hypoadrenalism and Hyperadrenalism. ( 28911156 )
2017
3
Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-β hydroxysteroid dehydrogenase type 1. ( 27060500 )
2016
4
In utero and neonate exposure to nonylphenol develops hyperadrenalism and metabolic syndrome later in life. I. First generation rats (F(1)). ( 22765982 )
2012
5
Hyperadrenalism in childhood and adolescence. ( 6721603 )
1984
6
The genesis and treatment of hyperadrenalism. ( 5776602 )
1969
7
Eye signs in patients with Cushing's syndrome and pituitary tumors: some observations related to chromophobe tumors and hyperadrenalism. ( 5299904 )
1967
8
Cushing's syndrome and the hypophysis. A re-evaluation of pituitary tumors and hyperadrenalism. ( 4284589 )
1965
9
Differential diagnosis of the month: hyperadrenalism. ( 5828286 )
1965
10
The periadrenal foetal adipose tissue (brown fat) in phaeochromocytoma and experimental hyperadrenalism. ( 13993019 )
1962
11
The course of rheumatoid arthritis during four years of induced hyperadrenalism (IHA). ( 13321366 )
1956
12
Pemphigus vulgaris; hyperadrenalism with osteoporosis. ( 12996080 )
1952
13
Absence of analgesia during induced hyperadrenalism. ( 14911892 )
1951
14
Subtotal Bilateral Adrenalectomy for Hyperadrenalism (Essential Hypertension). ( 17856349 )
1934

Variations for Hyperadrenalism

Expression for Hyperadrenalism

Search GEO for disease gene expression data for Hyperadrenalism.

Pathways for Hyperadrenalism

GO Terms for Hyperadrenalism

Sources for Hyperadrenalism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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