MCID: HYP043
MIFTS: 50

Hyperandrogenism

Categories: Endocrine diseases

Aliases & Classifications for Hyperandrogenism

MalaCards integrated aliases for Hyperandrogenism:

Name: Hyperandrogenism 12 76 55 44 15 73
Hyperandrogenization Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11613
MeSH 44 D017588
SNOMED-CT 68 237793004
UMLS 73 C0206081

Summaries for Hyperandrogenism

MalaCards based summary : Hyperandrogenism, also known as hyperandrogenization syndrome, is related to cortisone reductase deficiency and 3-beta-hydroxysteroid dehydrogenase deficiency. An important gene associated with Hyperandrogenism is WNT4 (Wnt Family Member 4), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Aldosterone synthesis and secretion. The drugs Cyproterone Acetate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Hyperandrogenism, also known as androgen excess, is a medical condition characterized by excessive... more...

Related Diseases for Hyperandrogenism

Diseases related to Hyperandrogenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 cortisone reductase deficiency 32.5 CYP21A2 HSD11B1
2 3-beta-hydroxysteroid dehydrogenase deficiency 30.9 CYP21A2 HSD3B2
3 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 30.3 CYP21A2 POMC
4 hyperthyroidism 30.0 INS PRL SHBG
5 acanthosis nigricans 30.0 IGF1 INS INSR PRL SHBG
6 central precocious puberty 29.8 GNRH1 IGF1
7 hyperglycemia 29.7 IGF1 INS INSR
8 alopecia, androgenetic, 1 29.5 CYP19A1 CYP21A2 SHBG
9 conn's syndrome 29.5 CYP17A1 CYP21A2 POMC
10 androgenic alopecia 29.5 CYP19A1 PRL SHBG
11 hyperinsulinism 29.5 IGF1 IGFBP1 INS INSR SHBG
12 leydig cell tumor 29.4 CYP17A1 CYP19A1 CYP21A2
13 diabetes mellitus, noninsulin-dependent 29.4 HSD11B1 IGF1 IGFBP1 INS INSR SHBG
14 adenoma 29.2 CYP21A2 IGF1 POMC PRL
15 precocious puberty 29.2 CYP19A1 CYP21A2 GNRH1
16 adrenal adenoma 29.1 CYP17A1 CYP21A2 HSD11B1 POMC
17 transsexualism 29.1 CYP17A1 CYP19A1 CYP21A2
18 diabetes mellitus 29.0 IGF1 IGFBP1 INS INSR SHBG
19 amenorrhea 29.0 GNRH1 POMC PRL SHBG WNT4
20 glucose intolerance 28.9 IGF1 IGFBP1 INS INSR SHBG
21 aromatase deficiency 28.7 CYP19A1 GNRH1 INS
22 bipolar disorder 28.6 IGF1 IGFBP1 PRL SHBG
23 infertility 28.5 CYP19A1 GNRH1 PRL
24 insulin-like growth factor i 28.4 IGF1 IGFBP1 INS INSR PRL SHBG
25 hyperprolactinemia 28.4 GNRH1 IGF1 POMC PRL SHBG
26 lipoid congenital adrenal hyperplasia 28.3 CYP17A1 CYP19A1 CYP21A2 HSD3B2 POMC
27 acromegaly 28.2 IGF1 IGFBP1 INS POMC PRL
28 anovulation 27.0 CYP19A1 GNRH1 IGF1 IGFBP1 INS PRL
29 endometrial cancer 26.9 CYP19A1 GNRH1 IGF1 IGFBP1 INS SHBG
30 ovarian disease 26.6 CYP19A1 GNRH1 IGF1 IGFBP1 INS PRL
31 polycystic ovary syndrome 26.1 CYP17A1 CYP19A1 CYP21A2 GNRH1 HSD3B2 IGF1
32 mullerian aplasia and hyperandrogenism 12.4
33 hyperandrogenism due to cortisone reductase deficiency 11.9
34 hair-an syndrome 11.8
35 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 11.5
36 cortisone reductase deficiency 1 11.0
37 cortisone reductase deficiency 2 11.0
38 mayer-rokitansky-kuster-hauser syndrome 10.8
39 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.8
40 brachyolmia type 4 with mild epiphyseal and metaphyseal changes 10.8
41 testotoxicosis 10.8
42 insulin autoimmune syndrome 10.8 INS INSR
43 hermaphroditism 10.7 SHBG WNT4
44 secondary adrenal insufficiency 10.7 IGF1 INS
45 scleredema adultorum 10.6 INS POMC
46 acute adrenal insufficiency 10.6 CYP21A2 POMC
47 galactorrhea 10.5 IGF1 PRL
48 pseudohypoparathyroidism, type ia 10.5 IGF1 PRL
49 acidophil adenoma 10.4 IGF1 POMC
50 abdominal obesity-metabolic syndrome 1 10.4 HSD11B1 INS

Graphical network of the top 20 diseases related to Hyperandrogenism:



Diseases related to Hyperandrogenism

Symptoms & Phenotypes for Hyperandrogenism

GenomeRNAi Phenotypes related to Hyperandrogenism according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.7 IGF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.7 IGF1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 CYP21A2 IGF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.7 INSR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.7 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.7 CYP21A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.7 IGF1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.7 INSR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.7 CYP21A2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.7 SHBG
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.7 IGF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.7 IGF1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.7 CYP21A2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.7 CYP21A2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.7 INSR SHBG CYP21A2 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.7 IGF1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.7 INSR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.7 INSR
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.7 INSR
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.7 IGF1

MGI Mouse Phenotypes related to Hyperandrogenism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 IGF1 CYP19A1 IGFBP1 INS HSD11B1 CYP17A1
2 endocrine/exocrine gland MP:0005379 10.09 GNRH1 INS HSD11B1 IGF1 CYP19A1 POMC
3 immune system MP:0005387 10.07 IGFBP1 GNRH1 INS HSD11B1 IGF1 CYP19A1
4 growth/size/body region MP:0005378 10.06 IGF1 CYP19A1 GNRH1 INS HSD11B1 CYP17A1
5 adipose tissue MP:0005375 10.02 INS HSD11B1 INSR CYP17A1 IGF1 CYP19A1
6 integument MP:0010771 9.92 CYP19A1 GNRH1 INS HSD11B1 IGF1 POMC
7 liver/biliary system MP:0005370 9.86 IGFBP1 INS GNRH1 HSD11B1 INSR CYP19A1
8 nervous system MP:0003631 9.81 CYP19A1 GNRH1 INS HSD11B1 IGF1 POMC
9 renal/urinary system MP:0005367 9.56 INS GNRH1 INSR CYP17A1 IGF1 CYP19A1
10 reproductive system MP:0005389 9.23 CYP19A1 GNRH1 INS CYP17A1 IGF1 PRL

Drugs & Therapeutics for Hyperandrogenism

Drugs for Hyperandrogenism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 216)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproterone Acetate Approved, Investigational Phase 4,Not Applicable 427-51-0
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 50-28-2 5757
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 979-32-8
4
Ethinyl Estradiol Approved Phase 4,Phase 2,Not Applicable 57-63-6 5991
5
Polyestradiol phosphate Approved Phase 4,Phase 2,Not Applicable 28014-46-2
6
Drospirenone Approved Phase 4 67392-87-4 68873
7
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
8
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
9
Simvastatin Approved Phase 4 79902-63-9 54454
10
Orlistat Approved, Investigational Phase 4,Phase 2 96829-58-2 3034010
11
Exenatide Approved, Investigational Phase 4,Phase 3 141758-74-9 15991534
12
Liraglutide Approved Phase 4 204656-20-2 44147092
13
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 1,Not Applicable 501-36-0 445154
14
Acarbose Approved, Investigational Phase 4,Not Applicable 56180-94-0 441184
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Not Applicable 58-05-9 143 6006
18
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
19
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
20
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 5280795
21
Enclomiphene Investigational Phase 4,Phase 3,Phase 2 15690-57-0
22 Androgen Antagonists Phase 4,Phase 2,Not Applicable
23 Androgens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Contraceptive Agents Phase 4,Phase 2,Not Applicable
25 Contraceptive Agents, Male Phase 4,Not Applicable
26
Cyproterone Phase 4,Not Applicable 2098-66-0 5284537
27 Estradiol 17 beta-cypionate Phase 4,Phase 2,Not Applicable
28 Estradiol 3-benzoate Phase 4,Phase 2,Not Applicable
29 Estrogens Phase 4,Phase 3,Phase 2,Not Applicable
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Antioxidants Phase 4,Not Applicable
34 Contraceptives, Oral Phase 4,Phase 2,Not Applicable
35 Contraceptives, Oral, Combined Phase 4,Phase 2,Not Applicable
36 Cyproterone acetate, ethinyl estradiol drug combination Phase 4,Not Applicable
37 diuretics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Drospirenone and ethinyl estradiol combination Phase 4
40 Hemostatics Phase 4
41 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
42 Mineralocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
43 Natriuretic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
44 Protective Agents Phase 4,Phase 3,Not Applicable
45 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
46 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
48 Chelating Agents Phase 4,Phase 3,Phase 2
49 Clomiphene Phase 4,Phase 3,Phase 2
50 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 128)
# Name Status NCT ID Phase Drugs
1 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4 Ethinyl Estradiol + Cyproterone acetate
2 Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants Unknown status NCT02027337 Phase 4 20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
3 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed NCT01360996 Phase 4 3 mg DRSP/20 μg EE
4 Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS Completed NCT00428311 Phase 4 Metformin;Ethynyl-estradiol plus cyproterone acetate
5 Role of Myo-inositol and D-chiro Inositol on the Ovaric and Metabolic Functions Completed NCT01626443 Phase 4
6 Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos. Completed NCT01896492 Phase 4 NAC
7 Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Completed NCT01021579 Phase 4 Metformin plus Placebo;Metfomin plus Simvastatin
8 Vitamin D Treatment, Pharmacogenetics and Glucose Metabolism Completed NCT01721915 Phase 4 Vitamin D supplementation;Placebo
9 The Effects of Vitamin D on Transforming Growth Factor-beta1 in Polycystic Ovary Syndrome Completed NCT02460380 Phase 4 Vitamin D3
10 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4 Drospirenone Ethinyl estradiol;Drospirenone Ethinyl estradiol Myo-inositol;placebo
11 Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS Recruiting NCT03252223 Phase 4 Recombinant Follicle Stimulating Hormone
12 The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS Recruiting NCT03151005 Phase 4 Metformin-GLP-1 Receptor Agonist;Metformin-Oral Contraceptive(OC)
13 Oral Contraceptive Therapy and Sexuality Recruiting NCT02613039 Phase 4 Combined Estrogen-Progestin Oral Contraceptives
14 Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients Recruiting NCT02766803 Phase 4 Simvastatin and micronized trans-resveratrol
15 Research of Exenatide for Overweight/Obese PCOS Patients With IGR Recruiting NCT03352869 Phase 4 Exenatide;Metformin
16 Research of Intensive Metabolic Intervention Before Pregnancy in PCOS Not yet recruiting NCT03383068 Phase 4 Acarbose 100 MG;Exenatide;Orlistat;Metformin
17 Effect of Bromocriptine on Insulin Resistance in Polycystic Ovarian Syndrome - A Pilot Study Unknown status NCT02133755 Phase 3 Bromocriptine
18 Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome Completed NCT01788215 Phase 3 doxycycline
19 The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women Completed NCT00413179 Phase 3 Metformin;Clomiphene citrate;Placebo
20 Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS Completed NCT01482286 Phase 3 Metformin
21 The Adrenal Contribution to Androgen Production in Girls During Puberty Completed NCT01062568 Phase 3 Adrenocorticotropin;Dexamethasone
22 Theca Cell Function in Women With Polycystic Ovary Syndrome (PCOS) Completed NCT00747617 Phase 3 recombinant human chorionic gonadotropin
23 Transdermal Testosterone Pretreatment in Poor Responders Undergoing IVF Completed NCT01961336 Phase 3 Testosterone
24 Obesity in Children and Adolescents: Associated Risks and Early Intervention Completed NCT01677923 Phase 3 Metformin
25 Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis Completed NCT02022007 Phase 3 Metformin XR;Saxagliptin;Saxagliptin-Metformin XR
26 The Effect of Vitamin D Supplementation Among Overweight Jordanian Women With Polycystic Ovary Syndrome (PCOS) Completed NCT02328404 Phase 3 50,000 IU vitamin D3;Placebo
27 Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman. Recruiting NCT03334682 Phase 3 spironolactone;Doxycycline
28 Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome Recruiting NCT03135301 Phase 3 letrozole plus metformin;letrozole
29 DAPA, EQW, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS) Recruiting NCT02635386 Phase 3 Exenatide once weekly (EQW );Dapagliflozin (DAPA);EQW plus DAPA;Dapagliflozin plus Glucophage (MET ER);Phentermine /Topiramate (PHEN/ TRP) ER
30 Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS Not yet recruiting NCT03480022 Phase 3 Liraglutide Pen Injector [Saxenda];Placebo Liraglutide Pen Injector
31 Clomiphene Citrate Plus Cabergoline in Treatment of Polycystic Ovary Syndrome Unknown status NCT02644304 Phase 2 Clomiphene citrate;Cabergoline
32 Phase II Randomized Study of Leuprolide Vs Oral Contraceptive Therapy Vs Leuprolide and Oral Contraceptive Therapy for Ovarian Hyperandrogenism Completed NCT00004763 Phase 2 leuprolide;Ethinyl estradiol/norethindrone
33 Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women Completed NCT00704912 Phase 2 Orlistat/Meal Replacement/Lifestyle Modification;Loestrin 1/20;Combination of treatments
34 Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome Completed NCT00004311 Phase 2 leuprolide acetate;spironolactone
35 Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasia Completed NCT01859312 Phase 2 Hydrocortisone (Solucortef)
36 Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients Completed NCT02562664 Phase 2 CC;Placebo tablets;Metformin
37 Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome Completed NCT03152591 Phase 2 LIK066;Placebo
38 Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women Recruiting NCT01889199 Phase 2 Flutamide
39 Acupuncture or Metformin for Insulin Resistance in Women With PCOS Recruiting NCT02647827 Phase 2 Metformin
40 Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant Enrolling by invitation NCT02523898 Phase 2 metformine;placebo;clomiphene citrate
41 Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction Not yet recruiting NCT03229408 Phase 2 Salsalate
42 Acupuncture to Treat Insulin Resistance in Women With and Without Polycystic Ovary Syndrome Completed NCT01457209 Phase 1
43 Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone Recruiting NCT01428089 Phase 1 Progesterone;Placebo
44 Effect of Metformin Therapy on Serum Under-carboxylated Osteocalcin Levels in Hyperandrogenic Lean Polycystic Ovarian Syndrome Women Recruiting NCT02244567 Phase 1 Metformin 850 mg twice daily for 3 months
45 Acute Effects of Progesterone on LH Pulses During the Follicular Phase (CRM006) Active, not recruiting NCT01602679 Phase 1 oral micronized progesterone suspension;Placebo
46 Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS) Terminated NCT01489319 Phase 1 Salsalate;Salsalate
47 Meal Timing on Glucose Metabolism and Hyperandrogenism in Lean Women With Polycystic Ovary Syndrome Unknown status NCT01569425 Not Applicable
48 Meal Timing on Glucose and Hyperandrogenism in PCOS Women Unknown status NCT01711476 Not Applicable
49 Ultrasound Three-dimensional Characterization of Ovarian Morphology in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT02402413 Not Applicable
50 Evaluation of Endocrine and Metabolic Parameters in the New Diagnostic Phenotypes of Polycystic Ovary Syndrome Unknown status NCT00784615

Search NIH Clinical Center for Hyperandrogenism

Cochrane evidence based reviews: hyperandrogenism

Genetic Tests for Hyperandrogenism

Anatomical Context for Hyperandrogenism

MalaCards organs/tissues related to Hyperandrogenism:

41
Ovary, Testes, Liver, Bone, Pituitary, Hypothalamus, Prostate

Publications for Hyperandrogenism

Articles related to Hyperandrogenism:

(show top 50) (show all 677)
# Title Authors Year
1
Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver. ( 29719598 )
2018
2
Heterogenous origins of hyperandrogenism in the polycystic ovary syndrome in relation to body mass index and insulin resistance. ( 29068242 )
2018
3
Hyperandrogenism Enhances Muscle Strength After Progressive Resistance Training, Independent of Body Composition, in Women With Polycystic Ovary Syndrome. ( 29927897 )
2018
4
Infertile polycystic ovary syndrome patients undergoing in vitro fertilization with the gonadotropin-releasing hormone-antagonist protocol: role of hyperandrogenism. ( 29376451 )
2018
5
Bariatric Surgery Improves Hyperandrogenism, Menstrual Irregularities, and Metabolic Dysfunction Among Women with Polycystic Ovary Syndrome (PCOS). ( 29500679 )
2018
6
Gut Microbial Diversity in Women with Polycystic Ovary Syndrome Correlates with Hyperandrogenism. ( 29370410 )
2018
7
Hyperandrogenism controversy in elite women's sport: an examination and critique of recent evidence. ( 29351951 )
2018
8
C-type natriuretic peptide: a link between hyperandrogenism and anovulation in a mouse model of polycystic ovary syndrome. ( 29739821 )
2018
9
Progesterone Suppression of Luteinizing Hormone Pulse Frequency in Adolescent Girls With Hyperandrogenism: Effects of Metformin. ( 29095983 )
2018
10
An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report. ( 29517680 )
2018
11
Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome. ( 29273198 )
2018
12
Hyperandrogenism Induces Histo-Architectural Changes in the Rat Uterus. ( 29929445 )
2018
13
The DNA methylation profile of oocytes in mice with hyperinsulinaemia and hyperandrogenism as detected by single-cell level whole genome bisulphite sequencing (SC-WGBS) technology. ( 29929576 )
2018
14
Effects of combined oral contraceptives on the clinical and biochemical parameters of hyperandrogenism in patients with polycystic ovary syndrome: a systematic review and meta-analysis. ( 29457756 )
2018
15
Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction. ( 29471520 )
2018
16
Improvement of hyperandrogenism, oligo-ovulation, and ovarian morphology in a patient with polycystic ovary syndrome: possible role of ovarian wedge resection. ( 29298536 )
2018
17
A question of 'fairness': Why ethics should factor in the Court of Arbitration for Sport's decision on the IAAF Hyperandrogenism Regulations. ( 29643090 )
2018
18
Adipose Tissue is a Potential Source of Hyperandrogenism in Obese Female Rats. ( 29901265 )
2018
19
High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice. ( 29535265 )
2018
20
Salivary testosterone may not serve as a screening test in the diagnosis of biochemical hyperandrogenism. ( 29517119 )
2018
21
Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS. ( 29161258 )
2017
22
Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients. ( 28271235 )
2017
23
The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse. ( 28961951 )
2017
24
Adrenal hyperandrogenism does not deteriorate insulin resistance and lipid profile in women with PCOS. ( 28912337 )
2017
25
Hyperandrogenism in a postmenopausal woman: a rare case of ectopic adrenal cortical gland. ( 28102088 )
2017
26
Effect of TNF-I+ on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome. ( 28946816 )
2017
27
Treatment of hyperandrogenism in women with ethinylestradiol and cyproteroneacetate. ( 28540758 )
2017
28
Value of selective venous catheterization in the diagnosis of hyperandrogenism. ( 29100622 )
2017
29
The BMP4-Smad signaling pathway regulates hyperandrogenism development in a female mouse model. ( 28572510 )
2017
30
ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne. ( 29497466 )
2017
31
Correction to: Fulghesu etA al., Very low dose of flutamide in the treatment of hyperandrogenism. ( 29171313 )
2017
32
Hyperandrogenism in adolescent girls: relationship with the somatotrophic axis. ( 28593921 )
2017
33
Obesity contributes more to increasing ApoB/ApoA1 ratio than hyperandrogenism in PCOS women aged 20-38 years in China. ( 28413474 )
2017
34
The Distribution of Stroma and Antral Follicles Differs between Insulin-Resistance and Hyperandrogenism-Related Polycystic Ovarian Syndrome. ( 28620353 )
2017
35
Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism. ( 28111236 )
2017
36
Association between biochemical hyperandrogenism parameters and Ferriman-Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta-regression analysis. ( 28575537 )
2017
37
The prevalence of non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency in Russian women with hyperandrogenism. ( 28669219 )
2017
38
An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients. ( 28125989 )
2017
39
A peel-off facial mask comprising myoinositol and trehalose-loaded liposomes improves adult female acne by reducing local hyperandrogenism and activating autophagy. ( 28342238 )
2017
40
Can the source of hyperandrogenism in adolescents with polycystic ovary syndrome predict metabolic phenotype? ( 28649885 )
2017
41
Transient hyperandrogenism in 2 preterm twins with exposure to antiretrovirals. ( 28864089 )
2017
42
Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review. ( 28183310 )
2017
43
Very low dose of flutamide in the treatment of hyperandrogenism. ( 29108453 )
2017
44
Polycystic ovary syndrome with hyperandrogenism as a risk factor for non-obese non-alcoholic fatty liver disease. ( 28370150 )
2017
45
Natural molecules for the therapy of hyperandrogenism and metabolic disorders in PCOS. ( 28724177 )
2017
46
Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels. ( 29760297 )
2017
47
Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life. ( 28089571 )
2017
48
Hyperandrogenism stimulates inflammation and promote apoptosis of cumulus cells. ( 29096744 )
2017
49
Identification of microRNAs and genes associated with hyperandrogenism in the follicular fluid of women with polycystic ovary syndrome. ( 29193229 )
2017
50
Correlation of clinical and biochemical hyperandrogenism in Thai women with polycystic ovary syndrome. ( 26890011 )
2016

Variations for Hyperandrogenism

Expression for Hyperandrogenism

Search GEO for disease gene expression data for Hyperandrogenism.

Pathways for Hyperandrogenism

Pathways related to Hyperandrogenism according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 IGF1 INS INSR PRL WNT4
2
Show member pathways
12.71 CYP17A1 CYP21A2 HSD3B2 INS POMC WNT4
3
Show member pathways
12.22 IGF1 INS INSR WNT4
4 12.14 CYP17A1 CYP19A1 IGFBP1 INS INSR
5
Show member pathways
11.92 IGF1 INS INSR
6
Show member pathways
11.85 IGF1 INS INSR
7 11.67 IGF1 INS INSR
8 11.62 CYP21A2 HSD3B2 POMC
9
Show member pathways
11.38 CYP17A1 CYP19A1 CYP21A2 HSD11B1 HSD3B2 POMC
10
Show member pathways
11.37 CYP17A1 CYP19A1 CYP21A2 HSD11B1 HSD3B2
11
Show member pathways
11.34 CYP17A1 CYP19A1 HSD3B2
12 11.28 INS INSR PRL
13 11.07 IGF1 INS INSR
14 10.88 IGF1 IGFBP1
15
Show member pathways
10.87 CYP17A1 CYP21A2
16 10.79 CYP17A1 CYP19A1 HSD3B2 IGF1 INS INSR
17 10.78 GNRH1 SHBG

GO Terms for Hyperandrogenism

Cellular components related to Hyperandrogenism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 GNRH1 IGF1 IGFBP1 INS POMC PRL
2 extracellular region GO:0005576 9.23 GNRH1 IGF1 IGFBP1 INS POMC PRL
3 endosome lumen GO:0031904 9.16 INS PRL

Biological processes related to Hyperandrogenism according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.99 CYP17A1 CYP19A1 CYP21A2 HSD11B1 HSD3B2
2 cellular protein metabolic process GO:0044267 9.87 IGF1 IGFBP1 INS PRL
3 positive regulation of MAPK cascade GO:0043410 9.8 IGF1 INS INSR
4 steroid metabolic process GO:0008202 9.78 CYP17A1 CYP21A2 HSD11B1
5 activation of MAPK activity GO:0000187 9.77 IGF1 INS INSR
6 insulin receptor signaling pathway GO:0008286 9.75 IGFBP1 INS INSR
7 response to nutrient levels GO:0031667 9.73 IGF1 INS PRL
8 regulation of signaling receptor activity GO:0010469 9.73 GNRH1 IGF1 INS POMC PRL WNT4
9 glucose homeostasis GO:0042593 9.71 IGF1 INS INSR POMC
10 positive regulation of DNA replication GO:0045740 9.69 IGF1 INS INSR
11 activation of protein kinase B activity GO:0032148 9.67 IGF1 INS INSR
12 positive regulation of glucose import GO:0046326 9.65 IGF1 INS INSR
13 sex differentiation GO:0007548 9.64 CYP17A1 WNT4
14 regulation of multicellular organism growth GO:0040014 9.63 IGF1 PRL
15 female gonad development GO:0008585 9.63 CYP19A1 WNT4
16 positive regulation of mitotic nuclear division GO:0045840 9.63 IGF1 INS INSR
17 adrenal gland development GO:0030325 9.62 INSR WNT4
18 positive regulation of insulin receptor signaling pathway GO:0046628 9.61 IGF1 INS
19 sterol metabolic process GO:0016125 9.61 CYP17A1 CYP19A1 CYP21A2
20 male sex determination GO:0030238 9.58 GNRH1 INSR
21 positive regulation of respiratory burst GO:0060267 9.55 INS INSR
22 neuron projection maintenance GO:1990535 9.54 INS INSR
23 positive regulation of glycolytic process GO:0045821 9.54 IGF1 INS INSR
24 mineralocorticoid biosynthetic process GO:0006705 9.52 CYP21A2 HSD3B2
25 positive regulation of glycogen biosynthetic process GO:0045725 9.5 IGF1 INS INSR
26 steroid biosynthetic process GO:0006694 9.46 CYP17A1 CYP19A1 CYP21A2 HSD3B2
27 androgen biosynthetic process GO:0006702 9.13 CYP17A1 HSD3B2 WNT4
28 glucocorticoid biosynthetic process GO:0006704 8.92 CYP17A1 CYP21A2 HSD11B1 HSD3B2

Molecular functions related to Hyperandrogenism according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.8 CYP17A1 CYP19A1 CYP21A2 HSD11B1 HSD3B2
2 iron ion binding GO:0005506 9.65 CYP17A1 CYP19A1 CYP21A2
3 heme binding GO:0020037 9.63 CYP17A1 CYP19A1 CYP21A2
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.54 CYP17A1 CYP19A1 CYP21A2
5 insulin receptor binding GO:0005158 9.49 IGF1 INS
6 insulin-like growth factor I binding GO:0031994 9.43 IGFBP1 INSR
7 steroid binding GO:0005496 9.33 CYP21A2 HSD11B1 SHBG
8 insulin-like growth factor II binding GO:0031995 9.32 IGFBP1 INSR
9 receptor activator activity GO:0030546 9.26 IGF1 INS
10 insulin-like growth factor receptor binding GO:0005159 9.13 IGF1 INS INSR
11 hormone activity GO:0005179 9.02 GNRH1 IGF1 INS POMC PRL

Sources for Hyperandrogenism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....