MCID: HYP021
MIFTS: 34

Hypercementosis

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Hypercementosis

MalaCards integrated aliases for Hypercementosis:

Name: Hypercementosis 12 76 53 55 44 15 73
Cementation Hyperplasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12733
ICD10 33 K03.4
ICD9CM 35 521.5
MeSH 44 D006936
SNOMED-CT 68 78537008
UMLS 73 C0020441

Summaries for Hypercementosis

MalaCards based summary : Hypercementosis, also known as cementation hyperplasia, is related to tooth resorption and root resorption, and has symptoms including toothache An important gene associated with Hypercementosis is GORAB (Golgin, RAB6 Interacting), and among its related pathways/superpathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. Related phenotypes are craniofacial and growth/size/body region

Wikipedia : 76 Hypercementosis is an idiopathic, non-neoplastic condition characterized by the excessive buildup of... more...

Related Diseases for Hypercementosis

Diseases related to Hypercementosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 tooth resorption 28.7 ACP5 CTSK DSPP PTH1R TNFRSF11A
2 root resorption 28.4 CTSK DSPP SPP1 TNFRSF11A
3 hypoplastic amelogenesis imperfecta 10.5 ENAM FAM20A
4 autosomal recessive hypophosphatemic rickets 10.5 ENPP1 FAM20A
5 hypocalcified amelogenesis imperfecta 10.5 DSPP ENAM
6 hypophosphatemic rickets, x-linked recessive 10.4 DSPP ENPP1
7 hypophosphatasia 10.4 DSPP ENPP1
8 dentin dysplasia, type ii 10.2 DSPP SPP1
9 dentin dysplasia 10.1 DSPP SPP1
10 hypophosphatasia, adult 10.1 ENPP1 SPP1
11 d-2-hydroxyglutaric aciduria 1 10.0 ACP5 PTH1R
12 periodontitis 10.0
13 tendinitis 9.9 ACP5 SPP1
14 enchondromatosis, multiple, ollier type 9.9 ACP5 PTH1R
15 ischemic bone disease 9.9 ACP5 TNFRSF11A
16 dental pulp calcification 9.8 DSPP ENAM SPP1
17 systemic lupus erythematosus 9.8
18 goiter 9.8
19 periodontal disease 9.8
20 hyperthyroidism 9.8
21 lupus erythematosus 9.8
22 exophthalmos 9.8
23 calcific tendinitis 9.7 CTSK SPP1
24 dentinogenesis imperfecta 9.7 DSPP SPP1
25 periapical periodontitis 9.7 ACP5 DSPP TNFRSF11A
26 teeth hard tissue disease 9.6 ACP5 DSPP ENAM FAM20A
27 skeletal dysplasias 9.6 CTSK PTH1R
28 multicentric carpotarsal osteolysis syndrome 9.5 ACP5 CTSK TNFRSF11A
29 bone giant cell tumor 9.4 ACP5 CTSK SPP1
30 bone remodeling disease 9.1 ACP5 CTSK SOST TNFRSF11A
31 bone resorption disease 8.4 ACP5 CTSK SOST SPP1 TNFRSF11A
32 bone disease 7.9 ACP5 CTSK PTH1R SOST SPP1 TNFRSF11A
33 osteoporosis 7.6 ACP5 CTSK GORAB PTH1R SOST SPP1

Graphical network of the top 20 diseases related to Hypercementosis:



Diseases related to Hypercementosis

Symptoms & Phenotypes for Hypercementosis

UMLS symptoms related to Hypercementosis:


toothache

MGI Mouse Phenotypes related to Hypercementosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.97 CTSK ENAM FAM20A GORAB MMP2 PTH1R
2 growth/size/body region MP:0005378 9.97 CTSK ENAM ENPP1 FAM20A MMP2 PTH1R
3 homeostasis/metabolism MP:0005376 9.91 SOST SPP1 TNFRSF11A CTSK ENAM ENPP1
4 limbs/digits/tail MP:0005371 9.55 CTSK FAM20A PTH1R SOST TNFRSF11A
5 respiratory system MP:0005388 9.5 CTSK FAM20A GORAB MMP2 PTH1R SPP1
6 skeleton MP:0005390 9.28 ENPP1 FAM20A MMP2 PTH1R SOST SPP1

Drugs & Therapeutics for Hypercementosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Buccodental Manifestations in Patients With Acromegaly Recruiting NCT03401008

Search NIH Clinical Center for Hypercementosis

Cochrane evidence based reviews: hypercementosis

Genetic Tests for Hypercementosis

Anatomical Context for Hypercementosis

Publications for Hypercementosis

Articles related to Hypercementosis:

(show all 46)
# Title Authors Year
1
Reduced Orthodontic Tooth Movement in Enpp1 Mutant Mice with Hypercementosis. ( 29533727 )
2018
2
Evaluation of the frequency and characteristics of hypercementosis in the turkish population with cone-beam computed tomography. ( 28656927 )
2017
3
Radiological prevalence of equine odontoclastic tooth resorption and hypercementosis. ( 29067719 )
2017
4
Hematologic, Biochemical, and Endocrine Parameters in Horses With Tooth Resorption and Hypercementosis. ( 28814178 )
2017
5
Hypercementosis Associated with ENPP1 Mutations and GACI. ( 29244957 )
2017
6
Radiographic evaluation in clinical practice of the types and stage of incisor tooth resorption and hypercementosis in horses. ( 27862232 )
2016
7
Determination and validation of criteria to define hypercementosis in two medieval samples from France (Sains-en-Gohelle, AD 7th-17th century; Jau-Dignac-et-Loirac, AD 7th-8th century). ( 25463907 )
2015
8
Novel treatment of equine odontoclastic tooth resorption and hypercementosis of incisor teeth in a 22-year-old Arabian mare. ( 26246633 )
2015
9
Equine Odontoclastic Tooth Resorption and Hypercementosis: Histopathologic Features. ( 26077784 )
2015
10
Hypercementosis: a rare finding in a patient with systemic lupus erythematosus. ( 25427926 )
2014
11
Localized multiple cemental excrescences: a rare presentation of hypercementosis. ( 24995256 )
2014
12
Clinical treatment and prognosis of equine odontoclastic tooth resorption and hypercementosis. ( 25557855 )
2014
13
Hypercementosis and concrescence of maxillary second molar with third molar: a case report and review of literature. ( 24984682 )
2014
14
Exuberant hypercementosis. ( 24357753 )
2013
15
Isolation of Treponema and Tannerella spp. from equine odontoclastic tooth resorption and hypercementosis related periodontal disease. ( 23742079 )
2013
16
Periodontitis with hypercementosis: report of a case and discussion of possible aetiologic factors. ( 23186579 )
2012
17
Occurrence of hypercementosis in a German population. ( 23146646 )
2012
18
Focal hypercementosis affecting a mandibular molar: a case report. ( 22313830 )
2011
19
Hypercementosis and odontogenic epithelial hyperplasia associated with a tooth root remnant mimicking a neoplasm. A case report. ( 20668326 )
2010
20
Equine odontoclastic tooth resorption and hypercementosis. ( 21140603 )
2010
21
A scanning electron microscopic study of hypercementosis. ( 19082395 )
2008
22
Hypercementosis. ( 18459677 )
2008
23
Equine odontoclastic tooth resorption and hypercementosis. ( 19010701 )
2008
24
Progressive, generalized, apical idiopathic root resorption and hypercementosis. ( 16274322 )
2005
25
Generalised hypercementosis: a case report. ( 15509438 )
2004
26
Atypical hypercementosis versus cementoblastoma. ( 15533983 )
2004
27
Duplication and dilaceration of a crown with hypercementosis of the root following trauma: a case report. ( 9922764 )
1998
28
Generalized hypercementosis in a young female patient. ( 9127369 )
1997
29
Case #3. Hypercementosis. ( 9442732 )
1997
30
Enlarged occlusal surfaces on first molars due to severe attrition and hypercementosis: examples from prehistoric coastal populations of Texas. ( 2648859 )
1989
31
Implications of tooth root hypercementosis in a Barbados slave skeletal collection. ( 3322025 )
1987
32
Generalized hypercementosis. ( 3473365 )
1987
33
Interpret your X-ray. Hypercementosis of the tooth root. ( 3868643 )
1985
34
Radiological diagnosis IX. Hypercementosis. ( 3867182 )
1985
35
Early hypercementosis and arrested dental eruption: heritable multiple ankylodontia. ( 6501562 )
1984
36
Hypercementosis--an important clue to Paget disease of the maxilla. ( 7163823 )
1982
37
A contribution to the histological study of hypercementosis using metal staining. ( 79581 )
1978
38
Hypercementosis. ( 5230346 )
1967
39
Differential radiological interpretation. The hypercementosis of Paget's disease. ( 5233296 )
1967
40
Effects of hypercementosis on the movability of teeth during orthdontic treatment. ( 5220824 )
1966
41
Effects of hypercementosis on the movability of teeth during orthodontic treatment. ( 5221250 )
1966
42
Hypercementosis, its developmental stage and effects on the movability of teeth during orthodontic treatment. ( 5222368 )
1965
43
HYPERCEMENTOSIS. ( 14049118 )
1963
44
The clinical significance of hypercementosis. ( 13120132 )
1954
45
Relationship of hypercementosis to the exophthalmos of hyperthyroidism. ( 13217541 )
1954
46
Correlation of hypercementosis with toxic goiter; a preliminary report. ( 14888775 )
1951

Variations for Hypercementosis

Expression for Hypercementosis

Search GEO for disease gene expression data for Hypercementosis.

Pathways for Hypercementosis

GO Terms for Hypercementosis

Cellular components related to Hypercementosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CTSK ENPP1 FAM20A MMP2 SOST SPP1
2 extracellular region GO:0005576 9.23 CTSK DSPP ENAM ENPP1 FAM20A MMP2

Biological processes related to Hypercementosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 ENAM MMP2 SPP1
2 extracellular matrix disassembly GO:0022617 9.54 CTSK MMP2 SPP1
3 embryo implantation GO:0007566 9.46 MMP2 SPP1
4 positive regulation of bone resorption GO:0045780 9.4 SPP1 TNFRSF11A
5 bone resorption GO:0045453 9.33 ACP5 CTSK PTH1R
6 riboflavin metabolic process GO:0006771 9.32 ACP5 ENPP1
7 intramembranous ossification GO:0001957 9.26 CTSK MMP2
8 ossification GO:0001503 9.26 DSPP PTH1R SOST TNFRSF11A
9 biomineral tissue development GO:0031214 9.02 DSPP ENAM ENPP1 FAM20A SPP1

Sources for Hypercementosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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