MCID: HYP021
MIFTS: 28

Hypercementosis

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Hypercementosis

MalaCards integrated aliases for Hypercementosis:

Name: Hypercementosis 12 73 20 54 44 15 17 70 32
Cementation Hyperplasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12733
ICD9CM 34 521.5
MeSH 44 D006936
SNOMED-CT 67 78537008
ICD10 32 K03.4
UMLS 70 C0020441

Summaries for Hypercementosis

MalaCards based summary : Hypercementosis, also known as cementation hyperplasia, is related to tooth resorption and ankylosis, and has symptoms including toothache An important gene associated with Hypercementosis is ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1). Affiliated tissues include bone and kidney, and related phenotype is craniofacial.

Wikipedia : 73 Hypercementosis is an idiopathic, non-neoplastic condition characterized by the excessive buildup of... more...

Related Diseases for Hypercementosis

Diseases related to Hypercementosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 tooth resorption 30.2 LAMC3 DSPP AMELX AMBN
2 ankylosis 30.0 PHOSPHO1 ENPP1
3 gingival recession 30.0 DSPP AMBN
4 arterial calcification of infancy 29.7 PHOSPHO1 ENPP1
5 dental abscess 10.2 ENPP1 DSPP
6 suppurative periapical periodontitis 10.2 DSPP AMBN
7 hypoplastic amelogenesis imperfecta 10.2 ENAM AMBN
8 t cell and nk cell immunodeficiency 10.2 FAM83H AMBN
9 periodontitis 10.2
10 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.2 AMELX AMBN
11 dentin caries 10.2 MMP20 DSPP
12 root caries 10.2 DSPP AMELX
13 dental pulp necrosis 10.1 DSPP AMELX
14 hermansky-pudlak syndrome 6 10.1 AMELX AMBN
15 periarthritis 10.1 PHOSPHO1 ENPP1
16 autosomal recessive hypophosphatemic rickets 10.1 ENPP1 DSPP
17 dental pulp disease 10.1 DSPP AMELX
18 hypophosphatemic rickets, x-linked recessive 10.1 ENPP1 DSPP
19 hypophosphatasia, adult 10.1 PHOSPHO1 ENPP1
20 immunodeficiency 10 10.1 FAM83H AMBN
21 adamantinous craniopharyngioma 10.1 MMP20 ENAM
22 enamel erosion 10.1 MMP20 AMELX
23 bone benign neoplasm 10.0 AMELX AMBN
24 hypophosphatasia, childhood 10.0 PHOSPHO1 ENPP1
25 amelogenesis imperfecta hypomaturation type 10.0 MMP20 AMELX
26 hypophosphatasia, infantile 10.0 PHOSPHO1 ENPP1
27 hair whorl 10.0
28 root resorption 10.0
29 mammary paget's disease 10.0
30 hyperthyroidism 10.0
31 dentine erosion 10.0 ENAM AMELX AMBN
32 amelogenesis imperfecta, type ib 10.0 ENAM AMELX AMBN
33 amelogenesis imperfecta, type ie 10.0 AMELX AMBN
34 hypophosphatasia 10.0 PHOSPHO1 ENPP1 DSPP
35 regional odontodysplasia 10.0 PAX9 DSPP
36 jalili syndrome 10.0 MMP20 FAM83H ENAM
37 amelogenesis imperfecta, type ic 9.9 MMP20 ENAM AMELX
38 papillary craniopharyngioma 9.9 MMP20 ENAM AMELX
39 ameloblastoma 9.9 MMP20 AMELX AMBN
40 hypophosphatemia 9.9 ENPP1 DSPP
41 systemic lupus erythematosus 9.9
42 triiodothyronine receptor auxiliary protein 9.9
43 arterial calcification, generalized, of infancy, 1 9.9
44 pulpitis 9.9
45 keratomalacia 9.9
46 goiter 9.9
47 acromegaly 9.9
48 gingivitis 9.9
49 paget's disease of bone 9.9
50 lupus erythematosus 9.9

Graphical network of the top 20 diseases related to Hypercementosis:



Diseases related to Hypercementosis

Symptoms & Phenotypes for Hypercementosis

UMLS symptoms related to Hypercementosis:


toothache

MGI Mouse Phenotypes related to Hypercementosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.1 AMBN ENAM ENPP1 FAM83H MMP20 PAX9

Drugs & Therapeutics for Hypercementosis

Search Clinical Trials , NIH Clinical Center for Hypercementosis

Cochrane evidence based reviews: hypercementosis

Genetic Tests for Hypercementosis

Anatomical Context for Hypercementosis

MalaCards organs/tissues related to Hypercementosis:

40
Bone, Kidney

Publications for Hypercementosis

Articles related to Hypercementosis:

(show top 50) (show all 123)
# Title Authors PMID Year
1
Regressive changes of the dental pulp complex in retained primary molars with congenitally missing successor teeth. 61 54
9643208 1997
2
Rough hypoplastic amelogenesis imperfecta with follicular hyperplasia. 54 61
1508515 1992
3
Incidence of hypercementosis in mandibular third molars determined using cone beam computed tomography. 61
33731505 2021
4
Orthodontic treatment of open bite involved in diffuse hypercementosis: A case report. 61
33203553 2021
5
Specific oral and maxillofacial identifiers in panoramic radiographs used for human identification. 61
33506528 2021
6
Update on Equine Odontoclastic Tooth Resorption and Hypercementosis. 61
33067098 2020
7
Odontoma associated with mandibular transmigrated canine in a geriatric patient: Second case report. 61
33179813 2020
8
Equine dental and skeletal fluorosis induced by well water consumption. 61
33140708 2020
9
Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study. 61
32738132 2020
10
Alternative Method for Full Oral Rehabilitation in Patients with Pycnodysostosis Syndrome: A Case Report. 61
32346314 2020
11
History, clinical findings and outcome of horses with radiographical signs of equine odontoclastic tooth resorption and hypercementosis. 61
31601733 2019
12
Generalised Hypercementosis in a Young Female Seeking Extraction: Revision and Update of Surgical Technique. 61
31659974 2019
13
Computer-aided design-guided endodontic microsurgery for a mandibular molar with hypercementosis. 61
31277917 2019
14
Radiographic evaluation and determination of hypercementosis patterns in Al-Madinah Al-Munawwarah, Saudi Arabia: A retrospective cross-sectional study. 61
31293261 2019
15
Hypercementosis and Cementoblastoma: Importance of the Histopathologic Analysis for the Correct Diagnosis. 61
31005619 2019
16
Radiographic Evaluation of Dental Anomaly Prevalence in a Selected Iranian Population. 61
31214635 2019
17
Florid hypercementosis synchronous with periodontitis: a case report. 61
31086857 2019
18
Radiological prevalence of equine odontoclastic tooth resorption and hypercementosis. 61
29067719 2018
19
Reduced Orthodontic Tooth Movement in Enpp1 Mutant Mice with Hypercementosis. 61
29533727 2018
20
Hypercementosis Associated with ENPP1 Mutations and GACI. 61
29244957 2018
21
Association of sickle cell haemoglobinopathies with dental and jaw bone abnormalities. 61
28833998 2018
22
Osteopontin regulates dentin and alveolar bone development and mineralization. 61
29313816 2018
23
Hematologic, Biochemical, and Endocrine Parameters in Horses With Tooth Resorption and Hypercementosis. 61
28814178 2017
24
[The mouth of patients with acromegaly]. 61
28943223 2017
25
Diagnoses and Treatment of Dental Disorders in a Research Colony of Macaca fascicularis: A Case Series. 61
28814183 2017
26
Radiographic evaluation in clinical practice of the types and stage of incisor tooth resorption and hypercementosis in horses. 61
27862232 2017
27
Evaluation of the frequency and characteristics of hypercementosis in the turkish population with cone-beam computed tomography. 61
28656927 2017
28
Craniometaphyseal Dysplasia: A review and novel oral manifestation. 61
28706789 2017
29
Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. 61
28095448 2017
30
Comparative analysis of dentognathic pathologies in the Dmanisi mandibles. 61
26919277 2016
31
Clinical treatment and prognosis of equine odontoclastic tooth resorption and hypercementosis. 61
25557855 2016
32
Oral and maxillofacial considerations in Gardner's syndrome: a report of two cases. 61
26981152 2016
33
Mucopolysaccharidosis: radiographic findings in a series of 16 cases. 61
26455293 2015
34
Equine Odontoclastic Tooth Resorption and Hypercementosis: Histopathologic Features. 61
26077784 2015
35
Novel treatment of equine odontoclastic tooth resorption and hypercementosis of incisor teeth in a 22-year-old Arabian mare. 61
26246633 2015
36
Tooth alterations in areas of bisphosphonate-induced osteonecrosis. 61
24948337 2015
37
Determination and validation of criteria to define hypercementosis in two medieval samples from France (Sains-en-Gohelle, AD 7th-17th century; Jau-Dignac-et-Loirac, AD 7th-8th century). 61
25463907 2015
38
The oral pathological conditions of the Broken Hill (Kabwe) 1 cranium. 61
29539491 2014
39
Hypercementosis: a rare finding in a patient with systemic lupus erythematosus. 61
25427926 2014
40
Hypercementosis and concrescence of maxillary second molar with third molar: a case report and review of literature. 61
24984682 2014
41
Localized multiple cemental excrescences: a rare presentation of hypercementosis. 61
24995256 2014
42
Isolation of Treponema and Tannerella spp. from equine odontoclastic tooth resorption and hypercementosis related periodontal disease. 61
23742079 2014
43
Irregular periapical radiopacity in mandibular premolars and molars. 61
24716003 2014
44
Finite element analysis of equine incisor teeth. Part 2: investigation of stresses and strain energy densities in the periodontal ligament and surrounding bone during tooth movement. 61
24252223 2013
45
Exuberant hypercementosis. 61
24357753 2013
46
Three-dimensional anatomy of equine incisors: tooth length, enamel cover and age related changes. 61
24321365 2013
47
A new understanding of oral and dental disorders of the equine incisor and canine teeth. 61
23915661 2013
48
The gold standard of dental care for the adult performance horse. 61
23915671 2013
49
Advances in the treatment of diseased equine incisor and canine teeth. 61
23915667 2013
50
FAM20A mutations can cause enamel-renal syndrome (ERS). 61
23468644 2013

Variations for Hypercementosis

Expression for Hypercementosis

Search GEO for disease gene expression data for Hypercementosis.

Pathways for Hypercementosis

GO Terms for Hypercementosis

Cellular components related to Hypercementosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 MMP20 LAMC3 ENPP1 ENAM DSPP AMELX
2 endoplasmic reticulum lumen GO:0005788 9.33 ENAM AMELX AMBN
3 extracellular matrix GO:0031012 9.1 PHOSPHO1 MMP20 LAMC3 ENAM DSPP AMELX

Biological processes related to Hypercementosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.58 ENAM AMELX AMBN
2 extracellular matrix organization GO:0030198 9.5 MMP20 LAMC3 DSPP
3 cellular protein metabolic process GO:0044267 9.43 ENAM AMELX AMBN
4 odontogenesis of dentin-containing tooth GO:0042475 9.37 AMELX AMBN
5 regulation of bone mineralization GO:0030500 9.16 PHOSPHO1 ENPP1
6 biomineral tissue development GO:0031214 9.1 FAM83H ENPP1 ENAM DSPP AMELX AMBN
7 amelogenesis GO:0097186 8.96 MMP20 ENAM

Molecular functions related to Hypercementosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 8.8 ENAM AMELX AMBN

Sources for Hypercementosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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