MCID: HYP018
MIFTS: 22

Hyperglobulinemic Purpura

Categories: Blood diseases

Aliases & Classifications for Hyperglobulinemic Purpura

MalaCards integrated aliases for Hyperglobulinemic Purpura:

Name: Hyperglobulinemic Purpura 12 15
Purpura, Hyperglobulinemic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3325
MeSH 44 D011694
SNOMED-CT 68 402852007
UMLS 73 C0034151

Summaries for Hyperglobulinemic Purpura

MalaCards based summary : Hyperglobulinemic Purpura, also known as purpura, hyperglobulinemic, is related to purpura and sjogren syndrome. An important gene associated with Hyperglobulinemic Purpura is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways is Primary immunodeficiency. Related phenotype is renal/urinary system.

Related Diseases for Hyperglobulinemic Purpura

Diseases related to Hyperglobulinemic Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 purpura 30.3 CD40LG CD79A
2 sjogren syndrome 29.0 CD79A HSPG2 TRIM21
3 primary hypomagnesemia 10.3 ATP6V0A4 BRD4
4 sialadenitis 10.3 HSPG2 TRIM21
5 mixed connective tissue disease 10.3 CD40LG HSPG2
6 hypokalemic periodic paralysis, type 1 10.3 ATP6V0A4 BRD4
7 lacrimal apparatus disease 10.2 HSPG2 TRIM21
8 multiple cranial nerve palsy 10.2 BRD4 CD40LG
9 facial hemiatrophy 10.2 CD40LG TRIM21
10 cutaneous lupus erythematosus 10.1 CD40LG TRIM21
11 myeloma, multiple 10.1
12 vasculitis 10.1
13 selective igg deficiency disease 10.0 CD40LG CD79A
14 c1q nephropathy 10.0 CD40LG CD79A
15 meningovascular neurosyphilis 10.0 CD40LG CD79A
16 alpha chain disease 10.0 CD40LG CD79A
17 brill-zinsser disease 10.0 CD40LG CD79A
18 exudative glomerulonephritis 10.0 CD40LG CD79A
19 cork-handlers' disease 10.0 CD40LG CD79A
20 salpingo-oophoritis 10.0 CD40LG CD79A
21 early yaws 10.0 CD40LG CD79A
22 ventilation pneumonitis 10.0 CD40LG CD79A
23 chronic interstitial cystitis 10.0 CD40LG CD79A
24 axillary adenitis 10.0 CD40LG CD79A
25 cryofibrinogenemia 10.0 CD40LG CD79A
26 trichostrongyloidiasis 10.0 CD40LG CD79A
27 subacute bacterial endocarditis 10.0 CD40LG CD79A
28 heterophyiasis 10.0 CD40LG CD79A
29 immunoglobulin g deficiency 10.0 CD40LG CD79A
30 orbital granuloma 10.0 CD40LG CD79A
31 transient hypogammaglobulinemia of infancy 10.0 CD40LG CD79A
32 gastroduodenitis 10.0 CD40LG CD79A
33 bacterial conjunctivitis 10.0 CD40LG CD79A
34 heavy chain disease 10.0 CD40LG CD79A
35 ophthalmia neonatorum 10.0 CD40LG CD79A
36 immunoglobulin a deficiency 1 10.0 CD40LG CD79A
37 parotid disease 10.0 CD40LG CD79A
38 cerebral arteritis 10.0 CD40LG CD79A
39 selective immunoglobulin deficiency disease 10.0 CD40LG CD79A
40 geniculate herpes zoster 10.0 CD40LG CD79A
41 erythema elevatum diutinum 10.0 CD40LG CD79A
42 sporotrichosis 10.0 CD40LG CD79A
43 fallopian tube disease 10.0 CD40LG CD79A
44 hyperimmunoglobulin syndrome 10.0 CD40LG CD79A
45 congenital syphilis 10.0 CD40LG CD79A
46 polyclonal hypergammaglobulinemia 10.0 CD40LG CD79A
47 monoclonal paraproteinemia 10.0 CD40LG CD79A
48 salpingitis 10.0 CD40LG CD79A
49 ocular toxoplasmosis 10.0 CD40LG CD79A
50 dysgammaglobulinemia 10.0 CD40LG CD79A

Graphical network of the top 20 diseases related to Hyperglobulinemic Purpura:



Diseases related to Hyperglobulinemic Purpura

Symptoms & Phenotypes for Hyperglobulinemic Purpura

MGI Mouse Phenotypes related to Hyperglobulinemic Purpura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 ATP6V0A4 CD40LG CD79A TRIM21

Drugs & Therapeutics for Hyperglobulinemic Purpura

Search Clinical Trials , NIH Clinical Center for Hyperglobulinemic Purpura

Cochrane evidence based reviews: purpura, hyperglobulinemic

Genetic Tests for Hyperglobulinemic Purpura

Anatomical Context for Hyperglobulinemic Purpura

Publications for Hyperglobulinemic Purpura

Articles related to Hyperglobulinemic Purpura:

(show all 22)
# Title Authors Year
1
Mycophenolate mofetil treatment of a patient with hyperglobulinemic purpura. ( 15455483 )
2004
2
Therapeutic effect of ethamsylate in a case of hyperglobulinemic purpura associated with Sjogren's syndrome. ( 8833011 )
1996
3
Benign hyperglobulinemic purpura of WaldenstrAPm: a report of seven patients and long-term follow-up. ( 3233123 )
1988
4
Hyperglobulinemic purpura, chronic sialoadenitis and the SjAPgren syndrome. ( 3473622 )
1986
5
Cutaneous leukocytoclastic vasculitis with hyperglobulinemia and splenomegaly. A variant of hyperglobulinemic purpura of WaldenstrAPm. ( 6206803 )
1984
6
WaldenstrAPm's hyperglobulinemic purpura: an unusual immune complex disorder. ( 6236022 )
1984
7
WaldenstrAPm's hyperglobulinemic purpura in HLA identical sisters. ( 6437921 )
1984
8
SjAPgren,'s syndrome and benign hyperglobulinemic purpura of Waldenstrom. ( 7325506 )
1981
9
Hyperglobulinemic purpura in the course of multiple myeloma. ( 6782799 )
1980
10
Immune complex vasculitis, polymyositis, and hyperglobulinemic purpura. ( 155783 )
1979
11
Systemic lupus erythematosus in twin sisters following ten years of hyperglobulinemic purpura (WaldenstrAPm). ( 1274678 )
1976
12
Monoclonal hyperglobulinemic purpura in multiple myeloma. IgG anti-IgG complexes as a pathogenetic factor. ( 4542372 )
1972
13
Hyperglobulinemic purpura. Report of a case and review of the literature. ( 5977724 )
1966
14
Hyperglobulinemic purpura terminating in myeloma, hyperlipemia, and xanthomatosis. ( 4158672 )
1965
15
IDIOPATHIC HYPERGLOBULINEMIC PURPURA. ( 14172210 )
1964
16
Treatment of two cases of hyperglobulinemic purpura with thioguanine. ( 13999713 )
1963
17
Benign hyperglobulinemic purpura. Relation to Mikulicz's disease, sicca syndrome, and epidermolysis bullosa dystrophica. ( 13706742 )
1961
18
Idiopathic benign hyperglobulinemic purpura. ( 13600675 )
1958
19
Hyperglobulinemic purpura; report of 14 cases fulfilling Waldenstrom's criteria. ( 13406348 )
1957
20
Some observations on hyperglobulinemic purpura (Waldenstrom's syndrome). ( 13444268 )
1957
21
Idiopathic benign hyperglobulinemic purpura. ( 13348833 )
1956
22
Benign hyperglobulinemic purpura: case report. ( 13125219 )
1954

Variations for Hyperglobulinemic Purpura

Expression for Hyperglobulinemic Purpura

Search GEO for disease gene expression data for Hyperglobulinemic Purpura.

Pathways for Hyperglobulinemic Purpura

Pathways related to Hyperglobulinemic Purpura according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Hyperglobulinemic Purpura

Biological processes related to Hyperglobulinemic Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Hyperglobulinemic Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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