MCID: HYP018
MIFTS: 28

Hyperglobulinemic Purpura

Categories: Blood diseases

Aliases & Classifications for Hyperglobulinemic Purpura

MalaCards integrated aliases for Hyperglobulinemic Purpura:

Name: Hyperglobulinemic Purpura 12 15 17
Purpura, Hyperglobulinemic 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3325
MeSH 43 D011694
SNOMED-CT 67 402852007
UMLS 71 C0034151

Summaries for Hyperglobulinemic Purpura

MalaCards based summary : Hyperglobulinemic Purpura, also known as purpura, hyperglobulinemic, is related to sialadenitis and sjogren syndrome. An important gene associated with Hyperglobulinemic Purpura is DPY30 (Dpy-30 Histone Methyltransferase Complex Regulatory Subunit), and among its related pathways/superpathways are NF-kappaB Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Affiliated tissues include liver, lung and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Hyperglobulinemic Purpura

Diseases related to Hyperglobulinemic Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 sialadenitis 30.1 TRIM21 TNFSF13B HSPG2
2 sjogren syndrome 30.0 TRIM21 TNFSF13B HSPG2 CD40LG
3 vasculitis 29.9 TNFSF13B TNFRSF1B CD40LG
4 myeloma, multiple 29.4 TNFSF13B CD40LG CD22 BRD4
5 autoimmune disease 28.0 TRIM21 TNFSF13B TNFRSF1B IL1RN CD40LG CD22
6 systemic lupus erythematosus 27.7 TRIM21 TNFSF13B TNFRSF1B IL1RN CD40LG CD22
7 purpura 11.1
8 liver cirrhosis 10.3
9 macroglobulinemia 10.3
10 polymyositis 10.3
11 parotid disease 10.3 TRIM21 CD40LG
12 parotitis 10.2 TRIM21 CD40LG
13 late yaws 10.2 NDUFS3 CD40LG
14 raynaud disease 10.2 TRIM21 CD40LG
15 drug allergy 10.2 HSPG2 CD40LG
16 childhood type dermatomyositis 10.1 TRIM21 TNFRSF1B
17 glossopharyngeal nerve paralysis 10.1 TNFRSF1B CD40LG
18 rheumatoid arthritis 10.1
19 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.1
20 xanthomatosis 10.1
21 deficiency anemia 10.1
22 lung abscess 10.1
23 familial periodic paralysis 10.1
24 alcoholic liver cirrhosis 10.1
25 renal tubular acidosis 10.1
26 hepatitis 10.1
27 epidermolysis bullosa 10.1
28 histiocytosis 10.1
29 epidermolysis bullosa dystrophica 10.1
30 hemolytic anemia 10.1
31 bronchitis 10.1
32 blood protein disease 10.1
33 arthritis 10.1
34 lupus erythematosus 10.1
35 lymphosarcoma 10.1
36 splenomegaly 10.1
37 familial periodic paralyses 10.1
38 periodic paralysis 10.1
39 argyria 10.1
40 chronic orbital inflammation 10.1 TNFRSF1B CD40LG
41 optic papillitis 10.1 TNFRSF1B CD40LG
42 collagen disease 10.1 TRIM21 HSPG2 CD40LG
43 opportunistic bacterial infectious disease 10.1 TNFRSF1B CD40LG
44 granulomatous hepatitis 10.1 TNFRSF1B CD40LG
45 alpha chain disease 10.1 CD40LG CD22
46 granulomatous dermatitis 10.1 TNFRSF1B CD40LG
47 good syndrome 10.1 TNFRSF1B CD40LG
48 iritis 10.1 TNFRSF1B CD40LG
49 iridocyclitis 10.0 TNFRSF1B CD40LG
50 chorioretinitis 10.0 TNFRSF1B CD40LG

Graphical network of the top 20 diseases related to Hyperglobulinemic Purpura:



Diseases related to Hyperglobulinemic Purpura

Symptoms & Phenotypes for Hyperglobulinemic Purpura

MGI Mouse Phenotypes related to Hyperglobulinemic Purpura:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CD22 CD40LG HSPG2 IL1RN LRP1 NDUFS3
2 immune system MP:0005387 9.23 CD22 CD40LG HSPG2 IL1RN LRP1 TNFRSF1B

Drugs & Therapeutics for Hyperglobulinemic Purpura

Search Clinical Trials , NIH Clinical Center for Hyperglobulinemic Purpura

Cochrane evidence based reviews: purpura, hyperglobulinemic

Genetic Tests for Hyperglobulinemic Purpura

Anatomical Context for Hyperglobulinemic Purpura

MalaCards organs/tissues related to Hyperglobulinemic Purpura:

40
Liver, Lung, Testes

Publications for Hyperglobulinemic Purpura

Articles related to Hyperglobulinemic Purpura:

(show top 50) (show all 86)
# Title Authors PMID Year
1
Refractory primary Sjögren syndrome successfully treated with bortezomib. 61
25539431 2015
2
Mycophenolate mofetil treatment of a patient with hyperglobulinemic purpura. 61
15455483 2004
3
Therapeutic effect of ethamsylate in a case of hyperglobulinemic purpura associated with Sjogren's syndrome. 61
8833011 1996
4
Hypergammaglobulinemic purpura of Waldenstrom associated with systemic lupus erythematosus: report of a case and review of the literature. 61
7539322 1995
5
[A case of primary Sjögren's syndrome presenting as osteomalacia secondary to renal tubular acidosis]. 61
1857996 1991
6
[Waldenström's hyperglobulinemic purpura. Apropos of a case]. 61
2264698 1990
7
[Distal tubular renal acidosis associated with hyperglobulinemic purpura and Sjõgren's syndrome]. 61
2716388 1989
8
Benign hyperglobulinemic purpura of Waldenström: a report of seven patients and long-term follow-up. 61
3233123 1988
9
[Waldenström's benign hyperglobulinemic purpura]. 61
3494293 1986
10
Hyperglobulinemic purpura, chronic sialoadenitis and the Sjögren syndrome. 61
3473622 1986
11
[Hyperglobulinemic purpura]. 61
4001472 1985
12
[Waldenström's hyperglobulinemic purpura in a patient with alcoholic liver cirrhosis]. 61
6523593 1984
13
Cutaneous leukocytoclastic vasculitis with hyperglobulinemia and splenomegaly. A variant of hyperglobulinemic purpura of Waldenström. 61
6206803 1984
14
Waldenström's hyperglobulinemic purpura in HLA identical sisters. 61
6437921 1984
15
Waldenström's hyperglobulinemic purpura: an unusual immune complex disorder. 61
6236022 1984
16
Cutaneous manifestations of primary Sjögren's syndrome: a reflection of vasculitis and association with anti-Ro(SSA) antibodies. 61
6341472 1983
17
[Waldenström's hyperglobulinemic purpura and Gougerot-Sjögren's syndrome]. 61
6660766 1983
18
Sjögren,'s syndrome and benign hyperglobulinemic purpura of Waldenstrom. 61
7325506 1981
19
[Rheumatoid arthritis associated with chronic active cirrhogenous hepatitis. Treatment by plasmapheresis of associated hyperglobulinemic purpura]. 61
7267358 1981
20
Hyperglobulinemic purpura in the course of multiple myeloma. 61
6782799 1980
21
[New results on hyperglobulinemic purpura of Waldenström in childhood (author's transl)]. 61
224310 1979
22
Immune complex vasculitis, polymyositis, and hyperglobulinemic purpura. 61
155783 1979
23
[Hematological manifestations and complications in Sjögren's syndrome (author's transl)]. 61
220711 1978
24
[A case of hyperglobulinemic purpura associated with chronic bronchitis and lung abscess]. 61
987142 1976
25
Systemic lupus erythematosus in twin sisters following ten years of hyperglobulinemic purpura (Waldenström). 61
1274678 1976
26
Purpura hyperglobulinemica (Waldenstrom). 61
1052727 1976
27
[On a case of "hyperglobulinemic purpura" in childhood]. 61
1113717 1975
28
Monoclonal hyperglobulinemic purpura in multiple myeloma. IgG anti-IgG complexes as a pathogenetic factor. 61
4542372 1972
29
[Case of hyperglobulinemic purpura--with statistical review of cases reported in Japan]. 61
5128053 1971
30
[Waldenström's hyperglobulinemic purpura in chronic aggressive hepatitis]. 61
5507852 1970
31
[Waldenstrom's hyperglobulinemic purpura and Gougerot-Sjoegren syndrome]. 61
5396957 1969
32
[Waldenstrom's hyperglobulinemic purpura and Gougerot-Sjogren syndrome]. 61
5405320 1969
33
[A fatal pathological condition with hyperglobulinemic purpura and polymyositis after phenylbutazone]. 61
5755571 1968
34
[On the therapy of Waldenström's hyperglobulinemic purpura by suppression of protein biosynthesis with cytostatic drugs]. 61
5703099 1968
35
[Waldenström's hyperglobulinemic purpura, Waldenström's macroglobulinemia]. 61
5005718 1968
36
[Waldenstrom's hyperglobulinemic purpura and the sicca syndrome]. 61
5586686 1967
37
[Sjogren's syndrome with paraproteinemia and hyperglobulinemic purpura]. 61
6047572 1967
38
[Waldenström's hyperglobulinemic purpura. Apropos of a case]. 61
5597453 1967
39
Hyperglobulinemic purpura. Report of a case and review of the literature. 61
5977724 1966
40
[A case of Waldenström's hyperglobulinemic purpura in a 14-year-old girl]. 61
5928336 1966
41
[Case of hyperlipemia with hyperglobulinemic purpura]. 61
5962745 1966
42
[The association of 2 rare diseases: Sjögren's syndrome and Waldenström's hyperglobulinemic purpura]. 61
5934946 1966
43
[Primary and secondary hyperglobulinemic purpura]. 61
5903558 1966
44
Hyperglobulinemic purpura terminating in myeloma, hyperlipemia, and xanthomatosis. 61
4158672 1965
45
[Benign hyperglobulinemic purpura with familial periodic paralysis; report of a case]. 61
5887597 1965
46
[Chronic focal oral infection as a factor causing the appearence of hemorrhagic hyperglobulinemic purpura of Waldenstrom]. 61
5841412 1965
47
[Case contribution to the study of nosologic problems inherent in Waldenström's hyperglobulinemic purpura]. 61
5831228 1964
48
IDIOPATHIC HYPERGLOBULINEMIC PURPURA. 61
14172210 1964
49
[Clinico-pathogenetic considerations on a case of Walderström's hyperglobulinemic purpura]. 61
5831229 1964
50
[ON HYPERGLOBULINEMIC PURPURA AND ACQUIRED HEMOLYTIC ANEMIA IN THE SAME PATIENT]. 61
14097951 1963

Variations for Hyperglobulinemic Purpura

Expression for Hyperglobulinemic Purpura

Search GEO for disease gene expression data for Hyperglobulinemic Purpura.

Pathways for Hyperglobulinemic Purpura

Pathways related to Hyperglobulinemic Purpura according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 TNFSF13B TNFRSF1B IL1RN CD40LG
2
Show member pathways
11.05 TNFSF13B TNFRSF1B CD40LG
3 10.84 TNFRSF1B CD40LG
4 10.76 LRP1 CD40LG
5
Show member pathways
10.66 TNFSF13B TNFRSF1B CD40LG

GO Terms for Hyperglobulinemic Purpura

Cellular components related to Hyperglobulinemic Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane protein complex GO:0098797 8.62 LRP1 HSPG2

Biological processes related to Hyperglobulinemic Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 TNFSF13B TNFRSF1B IL1RN CD40LG
2 inflammatory response GO:0006954 9.46 TNFRSF1B IL1RN HSPG2 CD40LG
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.13 TNFSF13B TNFRSF1B CD40LG
4 immunoglobulin secretion GO:0048305 8.62 TNFSF13B CD40LG

Molecular functions related to Hyperglobulinemic Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TNFSF13B CD40LG

Sources for Hyperglobulinemic Purpura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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