Hyperglycemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP066 MIFTS: 65	Hyperglycemia Categories: Blood diseases, Metabolic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Hyperglycemia

MalaCards integrated aliases for Hyperglycemia:

Name: Hyperglycemia ¹² ⁷⁷ ³⁰ ⁵⁶ ⁶ ⁴⁴ ⁴⁵ ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Abnormal findings on examination of blood, without diagnosis

Elevated blood glucose level

Hyperglycaemia, unspecified

External Ids:

Disease Ontology ¹² DOID:4195

MeSH ⁴⁵ D006943

NCIt ⁵¹ C26797

SNOMED-CT ⁶⁹ 80394007

ICD10 ³⁴ R73.9

UMLS ⁷⁴ C0020456

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Summaries for Hyperglycemia

MedlinePlus : ⁴⁴ Hyperglycemia means high blood sugar or glucose. Glucose comes from the foods you eat. Insulin is a hormone that moves glucose into your cells to give them energy. Hyperglycemia happens when your body doesn't make enough insulin or can't use it the right way. People with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. Other problems that can raise blood sugar include infections, certain medicines, hormone imbalances, or severe illnesses.

MalaCards based summary : Hyperglycemia is related to diabetes mellitus, transient neonatal, 1 and maturity-onset diabetes of the young, type 2, and has symptoms including seizures, fever and dyspnea. An important gene associated with Hyperglycemia is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Developmental Biology and Aldosterone synthesis and secretion. The drugs Zinc and Metformin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and brain, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : ⁷⁷ Hyperglycemia (also spelled hyperglycaemia or hyperglycæmia), is a condition in which an excessive... more...

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Related Diseases for Hyperglycemia

Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 468)

#	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus, transient neonatal, 1	32.8	ABCC8 INS KCNJ11
2	maturity-onset diabetes of the young, type 2	32.3	GCK HNF1A INS PDX1
3	diabetes mellitus, permanent neonatal	32.3	ABCC8 GCK INS KCNJ11 PDX1
4	diabetes mellitus, insulin-dependent	32.0	AKR1B1 ALB GCG GCK HNF1A IAPP
5	hyperinsulinism	32.0	ABCC8 GCK IGF1 INS INSR KCNJ11
6	microvascular complications of diabetes 1	31.9	AKR1B1 IGF1 INS SST
7	hypoglycemia	31.2	ABCC8 GCG GCK INS INSR KCNJ11
8	lipid metabolism disorder	30.9	ADIPOQ INS LEP PPARG
9	microvascular complications of diabetes 5	30.8	AKR1B1 ALB IGF1 INS
10	fatty liver disease, nonalcoholic 1	30.7	ADIPOQ INS LEP
11	microvascular complications of diabetes 3	30.6	ALB INS MALAT1
12	acromegaly	30.5	IGF1 INS SST
13	gestational diabetes	30.4	ADIPOQ GCK IAPP INS INSR KCNJ11
14	vascular disease	30.4	ADIPOQ ALB INS PPARG
15	diabetic neuropathy	30.4	AKR1B1 INS LEP
16	atherosclerosis susceptibility	30.4	ADIPOQ INS PPARG
17	arteries, anomalies of	30.3	ADIPOQ ALB INS LEP PPARG
18	liver disease	30.2	ADIPOQ ALB INS LEP
19	nonalcoholic fatty liver disease	30.2	ADIPOQ INS LEP
20	polycystic ovary syndrome	30.2	IGF1 INS INSR LEP
21	fanconi-bickel syndrome	30.2	ABCC8 INS SLC2A2
22	chronic kidney failure	30.2	ADIPOQ ALB IGF1 INS LEP
23	glucose intolerance	30.1	ADIPOQ DPP4 GCG GCK IGF1 INS
24	insulin-like growth factor i	30.1	IGF1 INS INSR LEP SST
25	sleep apnea	30.1	ADIPOQ IGF1 INS LEP
26	peripheral nervous system disease	30.0	AKR1B1 ALB INS
27	islet cell tumor	30.0	IAPP INS SST
28	hyperandrogenism	30.0	IGF1 INS INSR
29	uremia	29.9	ALB INS LEP
30	fatty liver disease	29.9	ADIPOQ INS INSR LEP MALAT1
31	monogenic diabetes	29.7	ABCC8 GCK HNF1A INS KCNJ11 PDX1
32	abdominal obesity-metabolic syndrome 1	29.7	ADIPOQ INS LEP PPARG
33	hyperthyroidism	29.7	INS LEP SST
34	insulinoma	29.6	ABCC8 GCG GCK IAPP INS PDX1
35	neonatal diabetes mellitus	29.6	ABCC8 GCK INS KCNJ11 PDX1 SLC2A2
36	prediabetes syndrome	29.5	ADIPOQ ALB DPP4 GCG INS LEP
37	maturity-onset diabetes of the young	29.4	ABCC8 DPP4 GCG GCK HNF1A IAPP
38	body mass index quantitative trait locus 11	29.1	ADIPOQ DPP4 GCG GCK IAPP IGF1
39	anorexia nervosa	29.1	ADIPOQ IGF1 LEP
40	diabetes mellitus	28.8	ABCC8 ADIPOQ AKR1B1 ALB DPP4 GCG
41	diabetes mellitus, noninsulin-dependent	28.8	ABCC8 ADIPOQ AKR1B1 ALB DPP4 GCG
42	diabetes mellitus, ketosis-prone	11.4
43	diabetes and deafness, maternally inherited	11.4
44	transient neonatal diabetes mellitus	11.4
45	mitochondrial complex iii deficiency, nuclear type 6	11.1
46	diabetes mellitus, insulin-dependent, 2	10.9
47	pancreas, dorsal, agenesis of	10.9
48	renal glucosuria	10.9
49	glycogen storage disease 0, liver	10.9
50	diabetes mellitus, insulin-dependent, 5	10.9

Graphical network of the top 20 diseases related to Hyperglycemia:

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Symptoms & Phenotypes for Hyperglycemia

UMLS symptoms related to Hyperglycemia:

seizures, fever, dyspnea, edema, cachexia, vertigo, headache, syncope, cyanosis, icterus, signs and symptoms, signs and symptoms, digestive, hot flushes, symptoms

MGI Mouse Phenotypes related to Hyperglycemia:

⁴⁷ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	ABCC8 ADIPOQ AKR1B1 ALB DPP4 GCK
2	growth/size/body region	MP:0005378	10.36	ADIPOQ AKR1B1 DPP4 GCK HNF1A IAPP
3	endocrine/exocrine gland	MP:0005379	10.32	ABCC8 ADIPOQ ALB DPP4 GCK HNF1A
4	behavior/neurological	MP:0005386	10.25	ADIPOQ AKR1B1 HNF1A INS INSR KCNJ11
5	adipose tissue	MP:0005375	10.18	ADIPOQ HNF1A IGF1 INS INSR KCNJ11
6	mortality/aging	MP:0010768	10.17	ADIPOQ AKR1B1 ALB GCK HNF1A IGF1
7	digestive/alimentary	MP:0005381	10.1	ALB HNF1A INS INSR LEP PDX1
8	liver/biliary system	MP:0005370	10.07	ADIPOQ ALB GCK HNF1A INS INSR
9	integument	MP:0010771	10.01	ADIPOQ HNF1A IGF1 INS KCNJ11 LEP
10	muscle	MP:0005369	10	ADIPOQ ALB HNF1A IGF1 INS INSR
11	renal/urinary system	MP:0005367	9.73	ADIPOQ AKR1B1 ALB GCK HNF1A IGF1
12	no phenotypic analysis	MP:0003012	9.7	ABCC8 HNF1A INS KCNJ11 PDX1 PPARG
13	skeleton	MP:0005390	9.32	ADIPOQ AKR1B1 HNF1A IAPP IGF1 INS

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Drugs & Therapeutics for Hyperglycemia

Drugs for Hyperglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 859)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Zinc

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

7440-66-6

32051

Metformin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

657-24-9

14219 4091

Glipizide

Approved, Investigational

Phase 4,Phase 3,Phase 2

29094-61-9

3478

Saxagliptin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

361442-04-8

11243969

Insulin glargine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

160337-95-1

Aripiprazole

Approved, Investigational

Phase 4,Phase 3

129722-12-9

60795

Dopamine

Approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

62-31-7, 51-61-6

681

Insulin glulisine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

207748-29-6

Insulin Detemir

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

169148-63-4

5311023

Acarbose

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

56180-94-0

441184

Exenatide

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

141758-74-9

15991534

Curcumin

Approved, Experimental, Investigational

Phase 4,Phase 2,Phase 3,Not Applicable

458-37-7

969516

Insulin Aspart

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

116094-23-6

16132418

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Parecoxib

Approved

Phase 4

198470-84-7

Celecoxib

Approved, Investigational

Phase 4,Phase 1,Phase 2

169590-42-5

2662

Aspirin

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

50-78-2

2244

Nitric Oxide

Approved

Phase 4,Phase 2,Not Applicable

10102-43-9

145068

AT-101

Approved, Investigational

Phase 4

90141-22-3, 652-67-5

12597

Isosorbide Dinitrate

Approved, Investigational

Phase 4

87-33-2

6883

Amlodipine

Approved

Phase 4

88150-42-9

2162

Doxazosin

Approved

Phase 4

74191-85-8

3157

Irbesartan

Approved, Investigational

Phase 4

138402-11-6

3749

Atenolol

Approved

Phase 4

29122-68-7

2249

Furosemide

Approved, Vet_approved

Phase 4,Phase 2

54-31-9

3440

Ramipril

Approved

Phase 4,Phase 3

87333-19-5

5362129

Hydrochlorothiazide

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

58-93-5

3639

Simvastatin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

79902-63-9

54454

Clonidine

Approved

Phase 4

4205-90-7

2803

Angiotensin II

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

68521-88-0, 11128-99-7, 4474-91-3

172198 65143

Valsartan

Approved, Investigational

Phase 4,Phase 1,Phase 2

137862-53-4

60846

Hydrocortisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

50-23-7

5754

Glucagon

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

16941-32-5

Hydrocortisone acetate

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

50-03-3

Moxonidine

Approved, Investigational

Phase 4

75438-57-2

4810

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-24-8

5755

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2921-57-5

Rosiglitazone

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

122320-73-4

77999

tannic acid

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

1401-55-4

Insulin Lispro

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

133107-64-9

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

94-09-7, 1994-09-7

2337

Somatostatin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

38916-34-6, 51110-01-1

53481605

Liraglutide

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

204656-20-2

44147092

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

1177-87-3

Nicotinamide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

98-92-0

936

Racepinephrine

Approved

Phase 4,Phase 3,Not Applicable

329-65-7

838

Epinephrine

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

51-43-4

5816

Interventional clinical trials:

(show top 50) (show all 2164)

#	Name	Status	NCT ID	Phase	Drugs
1	The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia	Unknown status	NCT02806999	Phase 4	Berberine; Insulin;Insulin
2	Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia	Unknown status	NCT01267448	Phase 4	Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
3	Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury	Unknown status	NCT02161055	Phase 4	Insulin
4	Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes (FIT)	Unknown status	NCT03057470	Phase 4	50% bolus insulin correction;100% bolus insulin correction;150% bolus insulin correction
5	Effect of Acute Hyperglycemia on Renal Tissue Oxygenation	Unknown status	NCT02346149	Phase 4
6	ß-Cell Function and Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients With Moderate Hyperglycemia	Unknown status	NCT01717911	Phase 4	Insulin;Metformin;Sitagliptin
7	Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia	Unknown status	NCT00541554	Phase 4	Abilify (aripiprazole)
8	Arterial Catheter to Monitor Glycemia	Unknown status	NCT01176279	Phase 4
9	Treatment With Continuous Sub-cutaneous Insulin Infusion Via a Portable Pump Versus Discontinuous Insulin Infusion Via Multiple-injections in Type 2 Diabetes	Unknown status	NCT02048189	Phase 4	LEVEMIR;APIDRA
10	A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU	Unknown status	NCT02491346	Phase 4
11	Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial)	Unknown status	NCT00858676	Phase 4	acarbose
12	The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients	Unknown status	NCT01270191	Phase 4	Exenatide;Humulin-N
13	Curcumin for Type 2 Diabetic Patients	Unknown status	NCT01052597	Phase 4	curcumin
14	Insulin Infusion Diabetes Ulcer	Unknown status	NCT00700154	Phase 4
15	Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery	Unknown status	NCT01930318	Phase 4	parecoxib
16	Type 2 Diabetes Mellitus and Atherosclerosis	Unknown status	NCT01250340	Phase 4	Aspirin;Placebo
17	Various Insulin Regimens for Diabetic Inpatients With Cirrhosis Trial	Unknown status	NCT01143948	Phase 4	Glargine & Glulisine;Regular insulin;NPH & regular insulin
18	Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus	Unknown status	NCT00446810	Phase 4	Benfotiamine;Placebo
19	Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus	Unknown status	NCT02011620	Phase 4
20	Exenatide and Brown Adipose Tissue	Unknown status	NCT03002675	Phase 4	Bydureon
21	Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes.	Unknown status	NCT00254085	Phase 4	Insulin Aspart
22	Nephropathy In Type 2 Diabetes and Cardio-renal Events	Unknown status	NCT00535925	Phase 4	current therapy;irbesartan;ramipril;hydrochlorothiazide;furosemide;amlodipine;atenolol;doxazosin;clonidine;insulin;simvastatin;fibrate;erythropoietin;aspirin
23	Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics	Unknown status	NCT01095822	Phase 4	Aliskiren + Valsartan
24	Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose	Unknown status	NCT00145353	Phase 4	Insulin NovoRapid versus Actrapid
25	Efficacy of Acarbose on Intestinal Microbiome and Incretins of Type 2 Diabetes	Unknown status	NCT01758471	Phase 4	Glipizide;Acarbose
26	Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity	Unknown status	NCT01180231	Phase 4	Moxonidine (Physiotens)
27	Bone Turnover in Type 2 Diabetes Patients	Unknown status	NCT00732121	Phase 4	Sitagliptin;Placebo
28	TReatment by Insulin Continuous Infusion in Type 2 DIAbetes	Unknown status	NCT01889914	Phase 4	2 different procedures of administration of insulin
29	Comparison Study of Insulin Glargine and NPH Insulin	Unknown status	NCT01854723	Phase 4	Switching to NPH insulin;Continuation of insulin glargine
30	Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2	Unknown status	NCT02719756	Phase 4	Metformin;Dapagliflozin;Metformin up-titration
31	6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome	Unknown status	NCT00127985	Phase 4	6-methyl-prednisolone
32	Intensity of Exercise and Glucose Metabolism	Unknown status	NCT01649219	Phase 4
33	Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance	Unknown status	NCT01052025	Phase 4	Curcumin
34	Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy	Unknown status	NCT03112538	Phase 4	Multiple daily injections of insulin
35	Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity	Unknown status	NCT01960205	Phase 4	Saxagliptin;saxagliptin;metformin
36	Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance	Unknown status	NCT00733174	Phase 4	Rosiglitazone;Placebo
37	Sitagliptin for Hyperglycemia in Patients With T2DM Undergoing Cardiac Surgery	Completed	NCT02556918	Phase 4	Sitagliptin;Placebo;Regular Human Insulin;Insulin glargine;Supplemental insulin (Insulin lispro);Supplemental insulin (Insulin aspart)
38	Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock	Completed	NCT02266264	Phase 4	Hydrocortisone
39	Sitagliptin in Non-Diabetic Patients Undergoing General Surgery	Completed	NCT02741687	Phase 4	Sitagliptin;Placebo;Supplemental insulin (insulin lispro);Supplemental insulin (insulin aspart);Long acting basal insulin (insulin detemir);Long acting basal insulin (insulin glargine)
40	Glucose Control for Glucocorticoid Induced Hyperglycemia During Chemotherapy	Completed	NCT02155374	Phase 4	Sliding scale insulin;Intermediate acting insulin;Glucose lowering medication;Chemotherapy
41	Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia	Completed	NCT01184014	Phase 4	NPH insulin plus Complete Insulin Orders;Complete Insulin Orders
42	Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery	Completed	NCT02443402	Phase 4	Sitagliptin;Placebo;Regular Human Insulin;Insulin glargine;Supplemental insulin (Insulin lispro);Supplemental insulin (Insulin aspart)
43	NPH and Regular Insulin in the Treatment of Inpatient Hyperglycemia: Comparison of 3 Basal-bolus Regimens	Completed	NCT02758522	Phase 4	Once-daily Insulin;Twice-daily Insulin;Triple-daily Insulin
44	The Management of Glucocorticoid-Induced Hyperglycemia in Hospitalized Patients	Completed	NCT01810952	Phase 4	Glargine insulin;Lispro insulin;NPH Insulin
45	Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly	Completed	NCT02060383	Phase 4	Pasireotide s.c.;Sitagliptin;Liraglutide;Insulin;Pasireotide LAR;Metformin
46	Intensive Insulin Therapy in Non-diabetic Patients With Acute Myocardial Infarction and Hyperglycaemia	Completed	NCT00362778	Phase 4	Insulin
47	Effect of Low-Dose Dexamethasone on the Incidence of Hyperglycemia Following Surgery	Completed	NCT01545700	Phase 4	Control-saline;Dexamethasone 4 mg;Dexamethasone 8 mg;Control saline;Dexamethasone 4 mg;Dexamethasone 8 mg
48	Study of a Model-based Approach to Blood Glucose Control in Very-low-birthweight Neonates	Completed	NCT01419873	Phase 4	Actrapid Human Insulin
49	Hyperglycemia and Cardiovascular Outcomes With Type 2 Diabetes	Completed	NCT00191282	Phase 4	Insulin lispro;Human insulin isophane suspension (NPH);Insulin glargine;Human insulin isophane suspension;Human insulin 30/70
50	A Study of Postprandial Hyperglycemia in Participants With Type 2 Diabetes	Completed	NCT01159938	Phase 4	Lispro

Search NIH Clinical Center for Hyperglycemia

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

insulin

insulin beef, isophane

insulin beef-pork, isophane

insulin degludec

insulin glargine

insulin human, isophane

insulin lispro

insulin pork, isophane

insulin, aspart protamine, human

insulin, aspart, human

insulin, glulisine, human

insulin, prompt zinc, beef

insulin, prompt zinc, beef-pork

insulin, prompt zinc, pork

insulin, protamine lispro, human

insulin, protamine zinc, beef

insulin, protamine zinc, beef-pork

insulin, protamine zinc, pork

insulin, regular, beef

insulin, regular, beef-pork

insulin, regular, pork

insulin, zinc, human

insulin, zinc, pork

insulin,detemir,human

insulin,regular,human buffered

lente insulin, beef

lente insulin, beef-pork

regular insulin, human

ultralente insulin, beef

ultralente insulin, beef-pork

ultralente insulin, human

Cochrane evidence based reviews: hyperglycemia

Sources

Genetic Tests for Hyperglycemia

Genetic tests related to Hyperglycemia:

#	Genetic test	Affiliating Genes
1	Hyperglycemia ³⁰

Sources

Anatomical Context for Hyperglycemia

MalaCards organs/tissues related to Hyperglycemia:

⁴²

Endothelial, Heart, Brain, Liver, Pancreas, Testes, Kidney

Sources

Publications for Hyperglycemia

Articles related to Hyperglycemia:

(show top 50) (show all 3791)

#	Title	Authors	Year
1	Regarding "Outcomes associated with hyperglycemia after abdominal aortic aneurysm repair". ( 30579453 )	Lareyre F...Raffort J	2019
2	Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetes rats. ( 30914353 )	Erukainure OL...Islam MS	2019
3	Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury. ( 30762009 )	Wei HJ...Zhang JN	2019
4	Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin. ( 30738804 )	Sun X...Norris AW	2019
5	Hyperglycemia recognised in early pregnancy is phenotypically type 2 diabetes mellitus not gestational diabetes mellitus: a case control study. ( 30913941 )	Agha-Jaffar R...Robinson S	2019
6	Hyperglycemia inhibition of endothelial miR-140-3p mediates angiogenic dysfunction in diabetes mellitus. ( 30862410 )	Wang D...Cheng S	2019
7	Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes and Childhood Glucose Metabolism. ( 30655380 )	Lowe WL...HAPO Follow-up Study Cooperative Research Group	2019
8	What Constitutes Ideal Perioperative Glycemic Control for Preventing Acute Postoperative Hyperglycemia in Surgical Patients with Nonalcoholic Fatty Liver Disease? ( 30685022 )	Hanazaki K...Namikawa T	2019
9	The effects of hyperglycemia on outcomes in surgical high-grade glioma patients. ( 30784896 )	Decker M...Rahman M	2019
10	Acute effects of hyperglycemia on the peripheral nervous system in zebrafish ( Danio Rerio) following nitroreductase-mediated β-cell ablation. ( 30726116 )	Rocker A...Clark JK	2019
11	Intestinal electrical stimulation attenuates hyperglycemia and prevents loss of pancreatic β cells in type 2 diabetic Goto-Kakizaki rats. ( 30728346 )	Ouyang X...Chen JDZ	2019
12	Evaluation of the Impact of an Inpatient Hyperglycemia Protocol on Glycemic Control. ( 30730832 )	Ilcewicz HN...Smith CB	2019
13	Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. ( 30739252 )	Piazza FV...Marcuzzo S	2019
14	Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance. ( 30755628 )	Gorski DJ...Fischer JW	2019
15	Intensive treatment of hyperglycemia in the acute phase of myocardial infarction: the tenuous balance between effectiveness and safety - a systematic review and meta-analysis of randomized clinical trials. ( 30758416 )	Negreiros PH...Carvalho LSF	2019
16	Intrauterine exposure to hyperglycemia retards the development of brown adipose tissue. ( 30759346 )	Yu DQ...Huang HF	2019
17	Diabetes Distress, Intentional Hyperglycemia at Work, and Glycemic Control Among Workers With Type 1 Diabetes. ( 30765430 )	Hansen UM...Willaing I	2019
18	Postoperative hyperglycemia in patients undergoing cytoreductive surgery and HIPEC: a cohort study. ( 30772524 )	DiSano JA...Pameijer CR	2019
19	Hyperglycemia is associated with psoriatic inflammation in both humans and mice. ( 30776434 )	Ikumi K...Yamazaki S	2019
20	Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm. ( 30776793 )	Zamir I...Domell?f M	2019
21	Hemoglobin A1c and Permissive Hyperglycemia in Patients in the Intensive Care Unit with Diabetes. ( 30784610 )	Balintescu A...M?rtensson J	2019
22	Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inﬂammation in high fat diet/streptozotocin treated rats. ( 30784905 )	Ni Z...Yin M	2019
23	Hyperglycemia aggravates spinal cord injury through endoplasmic reticulum stress mediated neuronal apoptosis, gliosis and activation. ( 30784940 )	Chen Z...Jin Q	2019
24	Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting a-Glucosidase. ( 30785285 )	Zhao X...Yue H	2019
25	Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects. ( 30789980 )	Tripathy D...DeFronzo RA	2019
26	p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. ( 30790589 )	Yokoyama M...Minamino T	2019
27	Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats. ( 30798121 )	Balakrishnan BB...Selvaraj A	2019
28	Ferulic Acid Protects Hyperglycemia-Induced Kidney Damage by Regulating Oxidative Insult, Inflammation and Autophagy. ( 30804780 )	Chowdhury S...Sil PC	2019
29	Cell Based Therapy for Type 1 Diabetes: Should We Take Hyperglycemia Into Account? ( 30804929 )	Grohov? A...Palov?-Jel?nkov? L	2019
30	Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice. ( 30805033 )	Yi JK...Kim SH	2019
31	Is the effect of hyperglycemia on liver 18F-FDG standardized uptake value really clinically significant? ( 30806749 )	Altmayer S...Hochhegger B	2019
32	The Paradox of Hyperglycemia and Surgical Outcomes in Patients with and without Diabetes. ( 30807266 )	Thompson R...Sobel M	2019
33	Spontaneous and transient hyperglycemia before sleep in a patient with glaucomatous blindness and diabetes: A case reprt. ( 30813182 )	Sun ZZ...Li W	2019
34	Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis. ( 30813579 )	Durrer C...Little JP	2019
35	A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. ( 30821687 )	Prada MP...Navedo MF	2019
36	Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans. ( 30823632 )	Perkins RK...Haus JM	2019
37	Maternal hyperglycemia disturbs neocortical neurogenesis via epigenetic regulation in C57BL/6J mice. ( 30824686 )	Ji S...Hao A	2019
38	Concurrent exercise training on hiperglicaemia and comorbidities associated: non-responders using clinical cutoff points. ( 30825342 )	?lvarez C...Izquierdo M	2019
39	Cardioprotective effect of 6-shogaol against hyperglycemia-induced toxicity in H9c2 cardiomyocytes via suppressing of NF-κB pathway. ( 30829211 )	Al-Malki WH...Abdel-Raheem IT	2019
40	Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. ( 30830866 )	Hirata Y...Ogawa W	2019
41	The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine. ( 30836124 )	Ma H...Ye X	2019
42	Effect of Hyperglycemia at Presentation on Outcomes in Acute Large Artery Occlusion Patients Treated With Solitaire Stent Thrombectomy. ( 30837929 )	Huo X...EAST Study Group	2019
43	TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells. ( 30842472 )	Cheng KC...Cheng JT	2019
44	Effects of Talinum triangulare leaf flavonoid extract on streptozotocin-induced hyperglycemia and associated complications in rats. ( 30847115 )	Oluba OM...Odutuga AA	2019
45	Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice. ( 30853374 )	Haller C...R-C Kraus M	2019
46	High Prevalence of Undiagnosed Hyperglycemia in Low-Income Overweight and Obese Hispanic Women in Oregon. ( 30859515 )	Lindberg NM...Turner A	2019
47	Preoperative fasting hyperglycemia is an independent prognostic factor for postoperative survival after gallbladder carcinoma radical surgery. ( 30863153 )	Zheng P...Zhang Q	2019
48	Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia. ( 30867247 )	Zhang J...Liu R	2019
49	Hyperglycemia and Hypokalemia in a 16-Year-Old Overweight Female Patient Misdiagnosed with Cushing Syndrome at First and Ultimately Diagnosed with Carney Complex Proven by PRKAR1A Gene Test: a Case Report and Literature Review. ( 30868845 )	Liu CH...Jin XP	2019
50	High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias. ( 30870879 )	Du P...Cheng LK	2019

Sources

Genes for Hyperglycemia

Genes related to Hyperglycemia (0 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MALAT1	Metastasis Associated Lung Adenocarcinoma Transcript 1	RNA Gene	150	Experimental evidence: Regulation ⁴⁰	25787249
2	INS	Insulin	Protein Coding	48.99	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	1452531 2272633 18596634 (more) 19487929 19623043 10591291 1727733 2257995 15823759 11815471 10421979 16735484 14987787 14993546 10599204 17973209 11132581 9346691 15199620 11796179 9691162 8487660 1425092 18470574 18556343 8822980 18477905 17109592 8474320 2134077 8039433 8720607 18220686 17950500 16612310 1513782 17599861 15251637 8941477 7729608 20001427 17224872 16428924 12962692 9313749 19278606 18482525 17065361 16363700 15694061 15458679 12221211 11679455 16972863 19212611 15103177 14767364 11079828 9662044 9589247 7534144 7851681 20078323 15655708 14604750 11791152 9051471 1991568 20176725 19140902 18809813 19008977 16919546 16015105 14551231 12819007 12656643 8299480 12840207 12652352 8013749 1727820 1566838 1972675 18375782 18045098 17068109 19307807 15894868 2210057 18469441 1499406 9314631 8923846 8911980 7670890 9477383 15520847 14747239
3	GCK	Glucokinase	Protein Coding	43.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	9049484 8720607 19309449 (more) 8826967 9357804 8433729 14517946 8932999 19934346 1354782 19411616 11872657 12542844 16444761 15677479 17216282 8132752 15929862 2240201 19790256 19125755 9713013 8878425 7789637 17488343 17414058 15102714 8168652 18297260 16925503 15677518 11554773 11272165 10525657 10480597 9539292 8591819 20458967 17186219 18301398 17186458 16556760 12765941 9662401 19564454 18556336 11393552 16731816 16380470 10753050 14578306 9710443
4	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	38.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	9075812 17389331 10819247 (more) 17207885 9799081
5	INSR	Insulin Receptor	Protein Coding	38.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10588370 10342822 10592293 (more) 7698515 8674872 11906473 11270675 7635966 11992868 14737743 16343639 17334654 18054736 7508912 9256480 16456234 15956119 15939413 11114100 8529791 16081595 12592403 11903393 10588371 20446576 17653211 17087288 16799396 15544481 18579738 14610924 11460589 18292430 16173935 15616014 15567345 9872935 17720889 19056296 11336594 11576522 12623164 12682618 16689387 16643434 1907347 12738810 7821730 19035155 8529511 7508875 10455187 7535776 16517960 7867639 12730204 18411068 10707037 11914741 7599689 8088709 10707549 9349593 8225693 11887975 11443207 19688022 9634724 1955101 17039177 16973725 7750630 16557003
6	HNF1A	HNF1 Homeobox A	Protein Coding	38.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	16444761 12453975 9539292 (more) 19794065
7	GCG	Glucagon	Protein Coding	34.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Functions (show sections)	19783893 19174495 7612912 (more) 19439067 9285204 10096792 8405741 9370106 20448799 10024091 19276444 18819251 16306549 12610039 11246876 8799658 1767243 19850204 15561910 15655716 14759561 11454146 20501434 17195423 16277173 15143860 12547550 11679463 19758106 19591659 19555131 18795210 10415574 20207828 15864535 11713984 11124853 9840447 9225821 8960841 8474320 19748061 18035865 8894501 9525985 11383230 19208912
8	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	33.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15539002 7838591 19383984 (more) 1314495 7839671 18451330 12490536 12604244 7557046 17003340 1611134 2114249 17720893 16625819 11422753 17720889 14751239 11353731 9709964 7497871 10421234 1908433 16297625 14610924 11460589 8681485 8457142 1748066 8877273 11336594 12682618 1828737 7963139 9676990
9	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	32.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17973209 15047634 19429700 (more) 17218834 17950098 18622594 19820028 19747747 15220246 20145925 18451326 20368216 17433469 19164335 18577692 12436346 17052201 14614541 17179929 16621799 16868887 18562232 18624998
10	KCNJ11	Potassium Voltage-Gated Channel Subfamily J Member 11	Protein Coding	32.25	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
11	IAPP	Islet Amyloid Polypeptide	Protein Coding	32.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8842609 1534057 16492545 (more) 17617279 1860552 9212322 11815498 16751351 1453875 9281227 18035865 19201608 19190104 16306549 17957149 7956938 9633536 9028722 7587855 18624122 18268000 9322799 8307253 8622964
12	DPP4	Dipeptidyl Peptidase 4	Protein Coding	31.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15864535 16939389 17160910 (more) 18035865 19555131 15143860 20197503 20448799
13	SST	Somatostatin	Protein Coding	31.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	7903954 1355580 1971827 (more) 10591291 1972675 7904782 8545317 7895951 18219490 7611393 8340056 12200764 11872657 9211494 18389272 12791513 10849575 9225821 14510913 14665723 8279535 19409239 17303805 15292365 14984315 12547550 7836708 1982386 1980259 18691043 12773135 1360156 9215304
14	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	31.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17532345 12643107 16644631 (more) 18769492 11729635 12628477 12689821 14624133 17722967 11581301 16567542 18095947 17593232 19628379 20145925 10859151 15708677 17826041 18220629
15	SLC5A2	Solute Carrier Family 5 Member 2	Protein Coding	31.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19232040 20425568 19357717 (more) 19125776 19243283
16	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	31.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	18086901 19393272 19656489 (more) 19817786 12173691
17	LEP	Leptin	Protein Coding	31.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19570342 12788860 17767817 (more) 9225821 8886745 9385619 19489767 9276727 9439547 10798377 17379009 9641678 9287057 16306549 15045701 12640189 9820079 9226485 19647774 17395684 19858588 10369428 14644019 11244470 18724043 10954026 12743644 11225217 9301425 18562232 15496495 2010535 12689528
18	IGF1	Insulin Like Growth Factor 1	Protein Coding	30.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16413942 18939362 17412627 (more) 9691162 1955101 12819007 9924360 15824155 18035140 2187189 7534144 15198124 8929861 10890193 11104267 10840365 7983791 11423485 18265556 15855342 12460458 12054122 17315038 9648485 7949222 20207740 19773182 19060447 19383984 14598295 12547889 10999789 20159489 16926523 17168853 14978159 11161963 10932965 10226799 1619015 2166697 20111736 18848411 16332921 7956938 7944536 1403403 18420583 17266031 16005252 18042318 17652764 12913330 10069661 17928399 7534902 8530617
19	ALB	Albumin	Protein Coding	30.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19968982 17767817 8243850 (more) 1289016 11935157 15769825 17393509 18928171 19349048 8773479 1511662 9492860 9288925 10737163 9588452 7814854 12679866 9849923 8157046 8307261 19923796 19624560 18688079 12639763 11876939 11735089 1500795 2111417 19401193 8840099 7811438 8270133 15313155 14733300 7708068 9365878 10615955 15505985 1756686 1507492 12489489
20	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	30.9	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	2237405 16223491
21	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	30.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11694852 20299674 20495289 (more) 14670831 15638868 19477910 9797717 11723063
22	IRS1	Insulin Receptor Substrate 1	Protein Coding	20.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15855318 8617880 20207740 (more) 17184177 11914741
23	UNC13B	Unc-13 Homolog B	Protein Coding	20.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
24	ST3GAL4	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4	Protein Coding	20.51	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10401233 11180699 11994404 (more) 15979893 18407527 19757377 10666008 11872670 12006365 11880921 9519717 19232850 17940666 20161908 19751257 19878567 18273752 14694265 18413164 18425420 20110858 10719242 10652031 10407491 19172850 17439741 14767489 16731816 9627363 16260351 17570261 18164317 8601643
25	G6PC	Glucose-6-Phosphatase Catalytic Subunit	Protein Coding	20.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19587243 9710443 17563061 (more) 18280254 18359296 12765941
26	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	20.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11440364 12787478 18180316 (more) 19331436 19099673 17682928 17214637 15094933 17319458 18839684 19531947 15340733 12365820 18996825 18578334 17935550 18358535 19188844 18691043
27	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	20.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19878258 18487451 19758106 (more) 19299027
28	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	20.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	14688680 11080093 16413942 (more) 9766571 10070142 10753038 8822374 9950801 10570081 20186957 18158647 19490621 9737725 12873613 12540631 10022440 10978417
29	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	20.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15793235 19587243 7772911 (more) 15809359 11851336 17563061
30	NOS3	Nitric Oxide Synthase 3	Protein Coding	20.02	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11696579 19584310 15479219 (more) 17101543 20238124 16775612 12819819 20357430 20446576 10893317 16643490 16085713 15479220 20124983
31	PRKCB	Protein Kinase C Beta	Protein Coding	19.81	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12540629 20184965 14986905 (more) 17494892 18220622 8489251 11304414 11151754
32	GCGR	Glucagon Receptor	Protein Coding	19.66	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19720878 18707090 11118010 (more) 15948676 17140563 15173883
33	TXNIP	Thioredoxin Interacting Protein	Protein Coding	19.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15128745 17575238 17555594 (more) 15687841 14531794
34	GIP	Gastric Inhibitory Polypeptide	Protein Coding	19.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10813588

Sources

Variations for Hyperglycemia

ClinVar genetic disease variations for Hyperglycemia:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	KLF11	NM_003597.4(KLF11): c.23G> A (p.Gly8Asp)	single nucleotide variant	Uncertain significance	rs1553312826	GRCh37	Chromosome 2, 10183866: 10183866
2	KLF11	NM_003597.4(KLF11): c.23G> A (p.Gly8Asp)	single nucleotide variant	Uncertain significance	rs1553312826	GRCh38	Chromosome 2, 10043739: 10043739

Copy number variations for Hyperglycemia from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	44162	10	52900000	70600000	Copy number	TFAM	Hyperglycemia

Sources

Expression for Hyperglycemia

Search GEO for disease gene expression data for Hyperglycemia.

Sources

Pathways for Hyperglycemia

Pathways related to Hyperglycemia according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁷ Show member pathways Axon guidance ⁶⁷	13.41	ADIPOQ GCK HNF1A IAPP INS LEP
2	Aldosterone synthesis and secretion ³⁸ Show member pathways Adrenergic signaling in cardiomyocytes ³⁸ Ca2+ activated K+ channels ⁶⁷ Cortisol synthesis and secretion ³⁸ Cushing syndrome ³⁸ Insulin secretion ³⁸ Melanogenesis ³⁸ Thyroid hormone synthesis ³⁸	12.87	ABCC8 ALB GCG GCK INS KCNJ11
3	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁸ AMPK Signaling Pathway ⁶⁸	12.37	ADIPOQ IGF1 INS INSR LEP PPARG
4	Prolactin Signaling Pathway ¹ ³⁸ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.35	GCK INS LEP SLC2A2
5	Integration of energy metabolism ⁶⁷ Show member pathways Acetylcholine regulates insulin secretion ⁶⁷ AMPK inhibits chREBP transcriptional activation activity ⁶⁷ ChREBP activates metabolic gene expression ⁶⁷ PKA-mediated phosphorylation of key metabolic factors ⁶⁷ PP2A-mediated dephosphorylation of key metabolic factors ⁶⁷ Regulation of insulin secretion ⁶⁷	12.3	ABCC8 ADIPOQ GCG INS KCNJ11 SLC2A2
6	Glucose / Energy Metabolism ⁴	12.25	ADIPOQ GCG HNF1A INS INSR PDX1
7	Peptide hormone metabolism ⁶⁷ Show member pathways Glycoprotein hormones ⁶⁷ Insulin processing ⁶⁷ Metabolism of Angiotensinogen to Angiotensins ⁶⁷ Peptide hormone biosynthesis ⁶⁷ Synthesis, secretion, and deacylation of Ghrelin ⁶⁷	12.18	DPP4 GCG IGF1 INS LEP
8	Longevity regulating pathway ³⁸ Show member pathways Longevity regulating pathway - multiple species ³⁸	12.09	ADIPOQ IGF1 INS INSR PPARG
9	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	12.02	ALB IGF1 INS PDX1 SLC2A2
10	Adipogenesis ¹	11.97	ADIPOQ HNF1A IGF1 INS LEP PPARG
11	Hepatic ABC Transporters ⁶⁵ Show member pathways MODY (Maturity-Onset Diabetes of Young) ⁶⁵	11.89	GCK HNF1A INS INSR PDX1 SLC2A2
12	Insulin resistance ³⁸ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.85	INS INSR SLC2A2
13	Glucagon signaling pathway ³⁸	11.81	GCG GCK SLC2A2
14	Hexose transport ⁶⁷ Show member pathways Glucose transport ⁶⁷	11.79	GCK SLC2A2 SLC5A2
15	HIF-1 signaling pathway ³⁸	11.78	IGF1 INS INSR
16	Regulation of beta-cell development ⁶⁷ Show member pathways Maturity onset diabetes of the young ³⁸ Regulation of gene expression in beta cells ⁶⁷ Regulation of gene expression in early pancreatic precursor cells ⁶⁷ Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells ⁶⁷ Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells ⁶⁷	11.73	GCK HNF1A IAPP INS PDX1 SLC2A2
17	Type II diabetes mellitus ³⁸ ¹ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶²	11.59	ABCC8 ADIPOQ GCK HNF1A INS INSR
18	Incretin synthesis, secretion, and inactivation

Hyperglycemia

Aliases & Classifications for Hyperglycemia

MalaCards integrated aliases for Hyperglycemia:

Classifications:

External Ids:

Summaries for Hyperglycemia

Related Diseases for Hyperglycemia

Diseases related to Hyperglycemia via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Hyperglycemia:

Symptoms & Phenotypes for Hyperglycemia

UMLS symptoms related to Hyperglycemia:

MGI Mouse Phenotypes related to Hyperglycemia:

Drugs & Therapeutics for Hyperglycemia

Drugs for Hyperglycemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: hyperglycemia

Genetic Tests for Hyperglycemia

Genetic tests related to Hyperglycemia:

Anatomical Context for Hyperglycemia

MalaCards organs/tissues related to Hyperglycemia:

Publications for Hyperglycemia

Articles related to Hyperglycemia:

Genes for Hyperglycemia

Genes related to Hyperglycemia (0 elite genes):

Variations for Hyperglycemia

ClinVar genetic disease variations for Hyperglycemia:

Copy number variations for Hyperglycemia from CNVD:

Expression for Hyperglycemia

Pathways for Hyperglycemia

Pathways related to Hyperglycemia according to GeneCards Suite gene sharing:

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :