HYPRG
MCID: HYP737
MIFTS: 37

Hyperhidrosis, Gustatory (HYPRG)

Categories: Mental diseases, Neuronal diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Hyperhidrosis, Gustatory

MalaCards integrated aliases for Hyperhidrosis, Gustatory:

Name: Hyperhidrosis, Gustatory 57
Frey Syndrome 57 12 20 15 17
Gustatory Sweating 57 12 20
Auriculotemporal Nerve Syndrome 57 20
Sweating, Gustatory 44 70
Frey's Syndrome 73 20
Auriculotemporal Syndrome 70
Gustatory Hyperhidrosis 12
Hyperhidrosis Gustatory 20
Baillarger Syndrome 12
Hyprg 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
hyperhidrosis, gustatory:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11599
OMIM® 57 144100
MeSH 44 D013547
SNOMED-CT 67 56046002
MedGen 41 C0038994
UMLS 70 C0038994 C0162473

Summaries for Hyperhidrosis, Gustatory

GARD : 20 Frey's syndrome is a rare, neurological disorder that causes a person to sweat excessively while eating. It most often occurs as a complication of surgery involving the parotid gland (a major salivary gland located below the ear). It may also occur following neck dissection, facelift procedures, or trauma to the area near the parotid gland. Symptoms usually develop within several months of the procedure or trauma, but may develop several years later. The main symptoms include flushing and excessive sweating ( hyperhidrosis ) on the cheek, temple, or behind the ear, when eating or thinking about food ( gustatory sweating ). Some people with Frey's syndrome may experience a burning sensation, itching, or pain around the affected area. The symptoms are usually mild but can be severe, causing significant discomfort or social anxiety. Frey's syndrome is thought to be caused by damage to both the nerves that regulate the sweat glands, and the nerves that regulate the parotid glands. It is believed that the damaged nerves regrow abnormally and connect to the wrong glands. Frey's syndrome is diagnosed based on medical history (e.g. a history of surgery or trauma) and symptoms. The diagnosis can be confirmed with a test called the Minor's starch-iodine test. Treatment, when needed, is focused on controlling the symptoms and often involves injections of botulinum toxin A (Botox) and/or topical antiperspirants. Repeat Botox injections are often needed as symptoms return, which occurs yearly on average. Of note, although Botox injections have been reported to improve symptoms and quality of life, no randomized controlled trials of its use to treat Frey's syndrome have been documented.

MalaCards based summary : Hyperhidrosis, Gustatory, also known as frey syndrome, is related to diabetic neuropathy and peripheral nervous system disease. An important gene associated with Hyperhidrosis, Gustatory is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Development Endothelin-1/EDNRA signaling. Affiliated tissues include salivary gland and skin, and related phenotypes are hyperhidrosis and integument

OMIM® : 57 Gustatory sweating results from a disruption of the auriculotemporal nerve pathways. Damage to the nerve may cause a misdirected regrowth that results in parasympathetic innervation of sympathetic receptors and, therefore, facial sweating and flushing with gustatory stimulation (summary by Dunbar et al., 2002). (144100) (Updated 05-Apr-2021)

Wikipedia : 73 Gustatory hyperhidrosis is excessive sweating classified under focal hyperhidrosis, that is, it is... more...

Related Diseases for Hyperhidrosis, Gustatory

Diseases related to Hyperhidrosis, Gustatory via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 diabetic neuropathy 29.7 TRPV1 TRPM8
2 peripheral nervous system disease 29.2 TRPV1 TRPM8 TRPA1 TAC1
3 trigeminal neuralgia 29.1 TRPV1 TRPM8 TRPA1 TAC1
4 autonomic neuropathy 10.3
5 neuropathy 10.3
6 facial paralysis 10.1
7 end stage renal disease 10.1
8 myofascial pain syndrome 10.1 TRPV1 TAC1
9 causalgia 10.1 TRPV1 TAC1
10 detrusor sphincter dyssynergia 10.1 TRPV1 TAC1
11 reflex sympathetic dystrophy 10.1 TRPV1 TAC1
12 vasomotor rhinitis 10.1 TRPV1 TAC1
13 chronic cystitis 10.1 TRPV1 TAC1
14 neurofibromatosis 10.1
15 cystitis 10.1 TRPV1 TAC1
16 dental pulp disease 10.1 TRPV1 TAC1
17 mononeuropathy 10.1 TRPV1 TAC1
18 nerve compression syndrome 10.1 TRPV1 TAC1
19 burning mouth syndrome 10.1 TRPV1 TAC1
20 anismus 10.1 VAPA TAC1
21 aspiration pneumonia 10.1 TRPV1 TAC1
22 angioedema 10.0
23 adenoma 10.0
24 erythromelalgia 10.0 TRPV1 TRPA1
25 neurogenic bladder 10.0 TRPV1 TAC1
26 dowling-degos disease 1 10.0
27 rheumatoid arthritis 10.0
28 syringomyelia, noncommunicating isolated 10.0
29 type 1 diabetes mellitus 10.0
30 branchiootic syndrome 1 10.0
31 meningioma, familial 10.0
32 microvascular complications of diabetes 3 10.0
33 microvascular complications of diabetes 4 10.0
34 microvascular complications of diabetes 6 10.0
35 microvascular complications of diabetes 7 10.0
36 epidemic typhus 10.0
37 ptosis 10.0
38 b-lymphoblastic leukemia/lymphoma 10.0
39 intracranial meningioma 10.0
40 xerophthalmia 10.0
41 salivary gland disease 10.0
42 anhidrosis 10.0
43 horner's syndrome 10.0
44 goiter 10.0
45 keratoconjunctivitis sicca 10.0
46 pneumothorax 10.0
47 melanoma 10.0
48 food allergy 10.0
49 syringomyelia 10.0
50 pleomorphic adenoma 10.0

Graphical network of the top 20 diseases related to Hyperhidrosis, Gustatory:



Diseases related to Hyperhidrosis, Gustatory

Symptoms & Phenotypes for Hyperhidrosis, Gustatory

Human phenotypes related to Hyperhidrosis, Gustatory:

31
# Description HPO Frequency HPO Source Accession
1 hyperhidrosis 31 HP:0000975

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Skin:
excessive facial sweating when eating spicy or sour foods

Clinical features from OMIM®:

144100 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Hyperhidrosis, Gustatory:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 TAC1 TRPA1 TRPM3 TRPM8 TRPV1

Drugs & Therapeutics for Hyperhidrosis, Gustatory

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy Completed NCT01414790 Phase 3

Search NIH Clinical Center for Hyperhidrosis, Gustatory

Cochrane evidence based reviews: sweating, gustatory

Genetic Tests for Hyperhidrosis, Gustatory

Anatomical Context for Hyperhidrosis, Gustatory

MalaCards organs/tissues related to Hyperhidrosis, Gustatory:

40
Salivary Gland, Skin

Publications for Hyperhidrosis, Gustatory

Articles related to Hyperhidrosis, Gustatory:

(show top 50) (show all 243)
# Title Authors PMID Year
1
Gustatory sweating: Frey syndrome. 57 61
16344505 2005
2
Understanding gustatory sweating. What have we learned from Lucja Frey and her predecessors? 57
12269550 2002
3
Botulinum toxin therapy in Frey's syndrome: a retrospective study of 440 treatments in 100 patients. 20
27513469 2017
4
Interventions for the treatment of Frey's syndrome. 20
25781421 2015
5
What is the best method for prevention of postparotidectomy Frey syndrome? Network meta-analysis. 61
33439485 2021
6
Endoscopic versus conventional parotid gland excision: a systematic review and meta-analysis. 61
33280943 2021
7
Reconstruction using sternocleidomastoid muscle flap versus posterior belly of digastric muscle flap compared with no reconstruction following superficial parotidectomy. 61
32827113 2021
8
Method to prevent cheek depression using an island sternocleidomastoid muscle flap with the middle pedicle as a feeding vessel in immediate reconstruction of the facial nerve with the sural nerve following resection of a parotid gland tumor. 61
33765741 2021
9
Not only gustatory sweating and flushing: Signs and symptoms associated to the Frey syndrome and the role of botulinum toxin A therapy. 61
33247501 2021
10
Comparison of postoperative complications and facial nerve recovery rates after conventional and partial superficial parotidectomy of benign parotid tumours: a prospective study. 61
32814655 2021
11
Adenoid Cystic Carcinoma Developed from the Parotid Gland to the Ear Lobe of a Young Woman. 61
33680648 2021
12
Outpatient vs inpatient parotidectomy: Systematic review and meta-analysis. 61
33009691 2021
13
Different Surgical Strategies in the Prevention of Frey Syndrome: A Systematic Review and Meta-analysis. 61
33502015 2021
14
Fat transfer after parotidectomy: fat resorption rates, aesthetic and functional outcomes of en-bloc fat graft versus lipofilling technique. 61
33471168 2021
15
Changing trends in the management of condylar fractures. 61
33020008 2020
16
Confronting the Challenges of Anatomy Education in a Competency-Based Medical Curriculum During Normal and Unprecedented Times (COVID-19 Pandemic): Pedagogical Framework Development and Implementation. 61
32873536 2020
17
[Application of retroauricular sulcus incision in surgery of parotid gland tumor]. 61
32911889 2020
18
Superficial Parotidectomy: Impact of Postoperative Drainage. 61
32744902 2020
19
Type a botulinum toxin in the management of spontaneous salivary otorrhea: a case report. 61
32787918 2020
20
Outpatient versus Inpatient Parotidectomy: A Systematic Review and Meta-analysis. 61
32286187 2020
21
Facial functional outcomes analysis after reconstruction by vascularized thoracodorsal nerve free flap following radical parotidectomy with facial nerve sacrifice. 61
31976612 2020
22
Frey syndrome-like developmental dysautonomia in a child with PHACE syndrome. 61
32101632 2020
23
Submandibular Frey Syndrome Following Submandibular Gland Excision. 61
30966801 2020
24
Superficial parotidectomy versus extracapsular dissection: literature review and search for a gold standard technique. 61
31301925 2020
25
Use of Botulinum Toxin in Orofacial Clinical Practice. 61
32053883 2020
26
Extracapsular dissection via sternocleidomastoid muscle-parotid space approach-a new operative technique for treating clinically benign tumor in the parotid tail. 61
31227451 2020
27
Frey syndrome in a child with neurofibromatosis type 1. 61
30551797 2020
28
Postoperative complications after removal of pleomorphic adenoma from the parotid gland: A long-term follow up of 297 patients from 2002 to 2016 and a review of publications. 61
31500918 2019
29
Teaching NeuroImages: Frey syndrome. 61
31740517 2019
30
Retromandibular transparotid approach compared with transmasseteric anterior parotid approach for the management of fractures of the mandibular condylar process: a prospective randomised study. 61
31402192 2019
31
Pleomorphic adenoma of the head and neck in children: presentation and management. 61
30431646 2019
32
Intra-auricular modification of facelift incision decreased the risk of Frey syndrome. 61
31867256 2019
33
[Analysis of predictors for Frey syndrome after parotidectomy]. 61
31446704 2019
34
Temporoparietal frey syndrome: An uncommon variant of a common syndrome. 61
30570147 2019
35
Resected specimen size: A reliable predictor of severe Frey syndrome after parotidectomy. 61
30758100 2019
36
Extracapsular dissection versus partial superficial parotidectomy for the treatment of benign parotid tumours. 61
30871850 2019
37
[Clinical value of V-shaped concealed incision in parotid benign tumors]. 61
31327198 2019
38
Minimal Scar Dissection for Partial Parotidectomy via a Modified Cosmetic Incision and an Advanced Wound Closure Method. 61
30922883 2019
39
Use of Parotid Gland Fascia in the Prevention of Frey Syndrome After Parotidectomy. 61
30882571 2019
40
Autologous Free Fat Graft for Repair of Concave Deformity After Total Parotidectomy. 61
30845078 2019
41
Mucoepidermoid carcinoma of the head and neck in children. 61
30772619 2019
42
Retrograde approach for parotid benign tumours: A review. 61
30125738 2019
43
Optimizing the Aesthetic Result of Parotidectomy with a Facelift Incision and Temporoparietal Fascia Flap. 61
30881826 2019
44
Comparison of surgical techniques for benign parotid tumours: a multicentre retrospective study. 61
30139711 2019
45
Surgical Treatment of Chronic Parotitis. 61
30647789 2019
46
Autonomic Cross-Innervation in Patients With Neurofibromatosis Type 2: Frey Syndrome and Unilateral Epiphora With Rhinorrhea. 61
31763344 2019
47
[Functional parotid surgery for removal of benign parotid tumors]. 61
30550215 2018
48
[Concurrence of Frey syndrome after treatment of parotid mixed tumor operation by the xenogenic a cellular dermal matrix hypodermic implantation: a case report]. 61
30453410 2018
49
Vascularised fatty tissue: its role in prevention of the symptoms of Frey syndrome after parotidectomy. 61
30337163 2018
50
Hidden Scar Dissection of Benign Parotid Gland Tumors via a V-Shaped Minimal Facelift Incision. 61
29894461 2018

Variations for Hyperhidrosis, Gustatory

Expression for Hyperhidrosis, Gustatory

Search GEO for disease gene expression data for Hyperhidrosis, Gustatory.

Pathways for Hyperhidrosis, Gustatory

Pathways related to Hyperhidrosis, Gustatory according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 TRPV1 TRPM8 TRPM3 TRPA1
2
Show member pathways
11.92 TRPV1 TRPM8 TRPA1
3
Show member pathways
11.75 TRPV1 TRPM8 TRPM3 TRPA1
4 10.32 TRPV1 TRPM8 TRPM3 TRPA1

GO Terms for Hyperhidrosis, Gustatory

Cellular components related to Hyperhidrosis, Gustatory according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 VAPA TRPV1 TRPM8 TRPM3 TRPA1 TBC1D10A

Biological processes related to Hyperhidrosis, Gustatory according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.83 TRPV1 TRPM8 TRPM3 TRPA1
2 transmembrane transport GO:0055085 9.81 TRPV1 TRPM8 TRPM3 TRPA1
3 ion transmembrane transport GO:0034220 9.76 TRPV1 TRPM8 TRPM3 TRPA1
4 cation transmembrane transport GO:0098655 9.58 TRPM8 TRPM3
5 cation transport GO:0006812 9.58 TRPM8 TRPM3
6 protein homotetramerization GO:0051289 9.57 TRPV1 TRPA1
7 cellular response to nerve growth factor stimulus GO:1990090 9.56 TRPV1 TAC1
8 calcium ion transport GO:0006816 9.56 TRPV1 TRPM8 TRPM3 TRPA1
9 release of sequestered calcium ion into cytosol GO:0051209 9.55 TRPV1 TRPA1
10 response to cold GO:0009409 9.54 TRPM8 TRPA1
11 sensory perception of pain GO:0019233 9.54 TRPV1 TRPA1 TAC1
12 negative regulation of heart rate GO:0010459 9.49 TRPV1 TAC1
13 divalent metal ion transport GO:0070838 9.48 TRPM8 TRPM3
14 calcium ion transmembrane transport GO:0070588 9.46 TRPV1 TRPM8 TRPM3 TRPA1
15 sensory perception of temperature stimulus GO:0050951 9.43 TRPM8 TRPM3
16 detection of temperature stimulus GO:0016048 9.4 TRPM8 TRPM3
17 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.32 TRPV1 TRPA1
18 response to pain GO:0048265 9.13 TRPV1 TRPA1 TAC1
19 thermoception GO:0050955 8.8 TRPV1 TRPM8 TRPA1

Molecular functions related to Hyperhidrosis, Gustatory according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation channel activity GO:0005261 9.33 TRPV1 TRPM8 TRPM3
2 calcium-release channel activity GO:0015278 9.26 TRPV1 TRPA1
3 ion channel activity GO:0005216 9.26 TRPV1 TRPM8 TRPM3 TRPA1
4 calcium channel activity GO:0005262 8.92 TRPV1 TRPM8 TRPM3 TRPA1

Sources for Hyperhidrosis, Gustatory

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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