MCID: HYP160
MIFTS: 27

Hyperkeratosis Lenticularis Perstans

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Hyperkeratosis Lenticularis Perstans

MalaCards integrated aliases for Hyperkeratosis Lenticularis Perstans:

Name: Hyperkeratosis Lenticularis Perstans 57 76 53 59 73
Flegel Disease 57 53 59
Hlp 57 53
Hyperkeratosis Lenticularis Perstans of Flegel 53
Flegel's Disease 53

Characteristics:

Orphanet epidemiological data:

59
hyperkeratosis lenticularis perstans
Inheritance: Autosomal dominant,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
hyperkeratosis lenticularis perstans:
Inheritance autosomal dominant inheritance
Onset and clinical course adult onset


Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

OMIM 57 144150
Orphanet 59 ORPHA409
MESH via Orphanet 45 C538377
UMLS via Orphanet 74 C0263420
MedGen 42 C0263420
UMLS 73 C0263420

Summaries for Hyperkeratosis Lenticularis Perstans

OMIM : 57 Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown keratotic papules that primarily affect the extremities. The disorder was first described by Flegel (1958) (summary by Bean, 1972). (144150)

MalaCards based summary : Hyperkeratosis Lenticularis Perstans, also known as flegel disease, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type iii. An important gene associated with Hyperkeratosis Lenticularis Perstans is HLP (Hyperkeratosis Lenticularis Perstans). Affiliated tissues include skin and t cells, and related phenotypes are pruritus and basal cell carcinoma

Wikipedia : 76 Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis), often... more...

Related Diseases for Hyperkeratosis Lenticularis Perstans

Diseases related to Hyperkeratosis Lenticularis Perstans via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hyperlipoproteinemia, type v 10.9
2 hyperlipoproteinemia, type iii 10.9
3 skin disease 10.2
4 candida glabrata 9.9

Symptoms & Phenotypes for Hyperkeratosis Lenticularis Perstans

Symptoms via clinical synopsis from OMIM:

57
Skin:
hyperkeratosis lenticularis perstans
hyperkeratotic pink or reddish-brown scaly 1 to 5 mm papules of lower leg and dorsum of foot

Misc:
lesions of trunk, thigh, arms and dorsum of the hand may occur
onset in third or fourth decade


Clinical features from OMIM:

144150

Human phenotypes related to Hyperkeratosis Lenticularis Perstans:

59 32 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 59 32 frequent (33%) Frequent (79-30%) HP:0000989
2 basal cell carcinoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0002671
3 squamous cell carcinoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0002860
4 hyperkeratosis lenticularis perstans 59 32 hallmark (90%) Very frequent (99-80%) HP:0007570
5 aplasia/hypoplasia of the skin 59 32 occasional (7.5%) Occasional (29-5%) HP:0008065
6 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
7 skin ulcer 59 32 frequent (33%) Frequent (79-30%) HP:0200042

Drugs & Therapeutics for Hyperkeratosis Lenticularis Perstans

Search Clinical Trials , NIH Clinical Center for Hyperkeratosis Lenticularis Perstans

Genetic Tests for Hyperkeratosis Lenticularis Perstans

Anatomical Context for Hyperkeratosis Lenticularis Perstans

MalaCards organs/tissues related to Hyperkeratosis Lenticularis Perstans:

41
Skin, T Cells

Publications for Hyperkeratosis Lenticularis Perstans

Articles related to Hyperkeratosis Lenticularis Perstans:

(show all 50)
# Title Authors Year
1
Hyperkeratosis lenticularis perstans in a patient with primary hyperaldosteronism. ( 29232039 )
2018
2
Hyperkeratosis lenticularis perstans bei einem Patienten mit primAorem Hyperaldosteronismus. ( 29314694 )
2018
3
Ein Fall von lokalisierter, unilateraler Hyperkeratosis lenticularis perstans an der Brust einer Frau. ( 27027754 )
2016
4
Dermoscopic findings in hyperkeratosis lenticularis perstans. ( 27846965 )
2016
5
Detection of Borrelia burgdorferi sensu stricto and Borrelia garinii DNAs in patient with Hyperkeratosis lenticularis perstans (Flegel disease). ( 26769152 )
2016
6
A case of localized, unilateral hyperkeratosis lenticularis perstans on a woman's breast. ( 27027755 )
2016
7
Hyperkeratosis lenticularis perstans: case report of a rare entity. ( 23716839 )
2013
8
Photoletter to the editor: Hyperkeratosis lenticularis perstans (Flegel's disease) with unusual clinical presentation. Response to isotretinoin therapy. ( 23091588 )
2012
9
Hyperkeratosis lenticularis perstans. ( 22068777 )
2011
10
Morphological evidence of periodical exacerbation of hyperkeratosis lenticularis perstans. ( 19386211 )
2009
11
Hyperkeratosis lenticularis perstans (Flegel's disease) - successful treatment with topical corticosteroids. ( 18986485 )
2008
12
Long-standing spiny papules on the lower extremities. Flegel disease, or hyperkeratosis lenticularis perstans (HLP). ( 19015429 )
2008
13
Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans (Flegel's disease). ( 16625073 )
2006
14
An unusual generalized form of hyperkeratosis lenticularis perstans (Flegel's disease). ( 15506318 )
2004
15
Case 3: widespread scaly papules affecting a patient's limbs and pinnae giving the skin a rough feeling. Diagnosis: Flegel's disease. Syn. hyperkeratosis lenticularis perstans. ( 12780736 )
2003
16
Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol. ( 11385235 )
2001
17
Hyperkeratosis lenticularis perstans (Flegel's disease): histologic, immunohistochemical, and ultrastructural features in a case. ( 10446786 )
1999
18
Unilateral hyperkeratosis lenticularis perstans (Flegel's disease). ( 9777782 )
1998
19
Multiple asymptomatic hyperkeratotic papules on the lower part of the legs. Hyperkeratosis lenticularis perstans (HLP) (Flegel disease). ( 9236534 )
1997
20
Hyperkeratosis lenticularis perstans (Flegel's disease). Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. ( 1469133 )
1992
21
Localized hyperkeratosis lenticularis perstans (Flegel's disease). ( 1935248 )
1991
22
Hyperkeratosis lenticularis perstans (Flegel's disease). In situ characterization of T cell subsets and Langerhans' cells. ( 2459881 )
1988
23
Hyperkeratosis lenticularis perstans. ( 3360552 )
1988
24
Hyperkeratosis lenticularis perstans (Flegel's disease). A light and electron microscopic study of involved and uninvolved epidermis. ( 3556701 )
1987
25
Lamellar bodies in hyperkeratosis lenticularis perstans. ( 3624584 )
1987
26
Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review. ( 3819050 )
1987
27
A clinicopathological study of Flegel's disease (hyperkeratosis lenticularis perstans). ( 2439113 )
1987
28
Langerhans cells in the dermal infiltrate of hyperkeratosis lenticularis perstans. ( 3804548 )
1986
29
Hyperkeratosis lenticularis perstans: report on three cases. ( 2420130 )
1985
30
Familial hyperkeratosis lenticularis perstans. Associated with cancers of the digestive organs. ( 6392388 )
1984
31
Hyperkeratosis lenticularis perstans (Flegel's disease). ( 6195872 )
1983
32
Biochemical analyses of stratum corneum in hyperkeratosis lenticularis perstans. ( 6188769 )
1982
33
Dyskeratotic process of hyperkeratosis lenticularis perstans (Flegel). The abnormal formation of cystine-rich protein. ( 7117641 )
1982
34
Retinoid acid in the treatment of hyperkeratosis lenticularis perstans Flegel. ( 6175154 )
1982
35
Treatment of hyperkeratosis lenticularis perstans (Flegel) with topical fluorouracil. ( 7364143 )
1980
36
Hyperkeratosis lenticularis perstans (Flegel). ( 7439482 )
1980
37
An ultrastructural study of the epidermis in hyperkeratosis lenticularis perstans. ( 82336 )
1978
38
Intracytoplasmic inclusions in dermal infiltrating cells of hyperkeratosis lenticularis perstans. ( 588458 )
1977
39
Hyperkeratosis lenticularis perstans (Flegel). A biological model for keratinization occurring in the absence of odland bodies? ( 65301 )
1976
40
Hyperkeratosis lenticularis perstans (Flegel). ( 4140664 )
1974
41
Letter: Hyperkeratosis lenticularis perstans. ( 4451399 )
1974
42
Hyperkeratosis lenticularis perstans (Flegel). An autosomal dominant skin disease due to lack of a keratinocytic organelle. ( 4430495 )
1974
43
Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. ( 4715122 )
1973
44
The genetics of hyperkeratosis lenticularis perstans. ( 5039109 )
1972
45
Coexistence of hyperkeratosis lenticularis perstans (Flegel) and hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle) in a patient. ( 4099145 )
1970
46
Hyperkeratosis lenticularis perstans. ( 5358103 )
1969
47
Hyperkeratosis lenticularis perstans. A clinical, histopathologic, and genetic study. ( 5783081 )
1969
48
Hyperkeratosis lenticularis perstans (Flegel). ( 5642681 )
1968
49
Hyperkeratosis lenticularis perstans (Flegel) or dyskeratotic psoriasiform dermatosis. A single dermatosis or two? ( 5673884 )
1968
50
Hyperkeratosis lenticularis perstans (Flegel): report of a case in which the application of betamethasone-17-valerate cream caused complete clearing of the lesions. ( 5590674 )
1967

Variations for Hyperkeratosis Lenticularis Perstans

Expression for Hyperkeratosis Lenticularis Perstans

Search GEO for disease gene expression data for Hyperkeratosis Lenticularis Perstans.

Pathways for Hyperkeratosis Lenticularis Perstans

GO Terms for Hyperkeratosis Lenticularis Perstans

Sources for Hyperkeratosis Lenticularis Perstans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....