HLP
MCID: HYP160
MIFTS: 28

Hyperkeratosis Lenticularis Perstans (HLP)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Hyperkeratosis Lenticularis Perstans

MalaCards integrated aliases for Hyperkeratosis Lenticularis Perstans:

Name: Hyperkeratosis Lenticularis Perstans 57 76 53 59 73
Flegel Disease 57 53 59
Hlp 57 53
Hyperkeratosis Lenticularis Perstans of Flegel 53
Flegel's Disease 53

Characteristics:

Orphanet epidemiological data:

59
hyperkeratosis lenticularis perstans
Inheritance: Autosomal dominant,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
hyperkeratosis lenticularis perstans:
Onset and clinical course adult onset
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

OMIM 57 144150
Orphanet 59 ORPHA409
MESH via Orphanet 45 C538377
UMLS via Orphanet 74 C0263420
MedGen 42 C0263420
UMLS 73 C0263420

Summaries for Hyperkeratosis Lenticularis Perstans

OMIM : 57 Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown keratotic papules that primarily affect the extremities. The disorder was first described by Flegel (1958) (summary by Bean, 1972). (144150)

MalaCards based summary : Hyperkeratosis Lenticularis Perstans, also known as flegel disease, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type iii. An important gene associated with Hyperkeratosis Lenticularis Perstans is HLP (Hyperkeratosis Lenticularis Perstans). Affiliated tissues include skin, t cells and breast, and related phenotypes are pruritus and skin ulcer

Wikipedia : 76 Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis), often... more...

Related Diseases for Hyperkeratosis Lenticularis Perstans

Diseases related to Hyperkeratosis Lenticularis Perstans via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hyperlipoproteinemia, type v 11.1
2 hyperlipoproteinemia, type iii 11.1
3 skin disease 10.4
4 candida glabrata 10.3

Symptoms & Phenotypes for Hyperkeratosis Lenticularis Perstans

Symptoms via clinical synopsis from OMIM:

57
Skin:
hyperkeratosis lenticularis perstans
hyperkeratotic pink or reddish-brown scaly 1 to 5 mm papules of lower leg and dorsum of foot

Misc:
lesions of trunk, thigh, arms and dorsum of the hand may occur
onset in third or fourth decade


Clinical features from OMIM:

144150

Human phenotypes related to Hyperkeratosis Lenticularis Perstans:

59 32 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 59 32 frequent (33%) Frequent (79-30%) HP:0000989
2 skin ulcer 59 32 frequent (33%) Frequent (79-30%) HP:0200042
3 aplasia/hypoplasia of the skin 59 32 occasional (7.5%) Occasional (29-5%) HP:0008065
4 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
5 squamous cell carcinoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0002860
6 basal cell carcinoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0002671
7 hyperkeratosis lenticularis perstans 59 32 hallmark (90%) Very frequent (99-80%) HP:0007570

Drugs & Therapeutics for Hyperkeratosis Lenticularis Perstans

Search Clinical Trials , NIH Clinical Center for Hyperkeratosis Lenticularis Perstans

Genetic Tests for Hyperkeratosis Lenticularis Perstans

Anatomical Context for Hyperkeratosis Lenticularis Perstans

MalaCards organs/tissues related to Hyperkeratosis Lenticularis Perstans:

41
Skin, T Cells, Breast

Publications for Hyperkeratosis Lenticularis Perstans

Articles related to Hyperkeratosis Lenticularis Perstans:

(show top 50) (show all 51)
# Title Authors Year
1
Hyperkeratosis lenticularis perstans in a patient with primary hyperaldosteronism. ( 29232039 )
2018
2
Hyperkeratosis lenticularis perstans bei einem Patienten mit primärem Hyperaldosteronismus. ( 29314694 )
2018
3
Ein Fall von lokalisierter, unilateraler Hyperkeratosis lenticularis perstans an der Brust einer Frau. ( 27027754 )
2016
4
Dermoscopic findings in hyperkeratosis lenticularis perstans. ( 27846965 )
2016
5
Detection of Borrelia burgdorferi sensu stricto and Borrelia garinii DNAs in patient with Hyperkeratosis lenticularis perstans (Flegel disease). ( 26769152 )
2016
6
A case of localized, unilateral hyperkeratosis lenticularis perstans on a woman's breast. ( 27027755 )
2016
7
A Case of Infantile Kyrle-Flegel Disease in a 6-Year-Old Yemeni Girl. ( 26933407 )
2016
8
Hyperkeratosis lenticularis perstans: case report of a rare entity. ( 23716839 )
2013
9
Photoletter to the editor: Hyperkeratosis lenticularis perstans (Flegel's disease) with unusual clinical presentation. Response to isotretinoin therapy. ( 23091588 )
2012
10
Hyperkeratosis lenticularis perstans. ( 22068777 )
2011
11
Morphological evidence of periodical exacerbation of hyperkeratosis lenticularis perstans. ( 19386211 )
2009
12
Hyperkeratosis lenticularis perstans (Flegel's disease) - successful treatment with topical corticosteroids. ( 18986485 )
2008
13
Long-standing spiny papules on the lower extremities. Flegel disease, or hyperkeratosis lenticularis perstans (HLP). ( 19015429 )
2008
14
Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans (Flegel's disease). ( 16625073 )
2006
15
An unusual generalized form of hyperkeratosis lenticularis perstans (Flegel's disease). ( 15506318 )
2004
16
Case 3: widespread scaly papules affecting a patient's limbs and pinnae giving the skin a rough feeling. Diagnosis: Flegel's disease. Syn. hyperkeratosis lenticularis perstans. ( 12780736 )
2003
17
Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol. ( 11385235 )
2001
18
Hyperkeratosis lenticularis perstans (Flegel's disease): histologic, immunohistochemical, and ultrastructural features in a case. ( 10446786 )
1999
19
Unilateral hyperkeratosis lenticularis perstans (Flegel's disease). ( 9777782 )
1998
20
Multiple asymptomatic hyperkeratotic papules on the lower part of the legs. Hyperkeratosis lenticularis perstans (HLP) (Flegel disease). ( 9236534 )
1997
21
Hyperkeratosis lenticularis perstans (Flegel's disease). Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. ( 1469133 )
1992
22
Localized hyperkeratosis lenticularis perstans (Flegel's disease). ( 1935248 )
1991
23
Hyperkeratosis lenticularis perstans (Flegel's disease). In situ characterization of T cell subsets and Langerhans' cells. ( 2459881 )
1988
24
Hyperkeratosis lenticularis perstans. ( 3360552 )
1988
25
Hyperkeratosis lenticularis perstans (Flegel's disease). A light and electron microscopic study of involved and uninvolved epidermis. ( 3556701 )
1987
26
Lamellar bodies in hyperkeratosis lenticularis perstans. ( 3624584 )
1987
27
Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review. ( 3819050 )
1987
28
A clinicopathological study of Flegel's disease (hyperkeratosis lenticularis perstans). ( 2439113 )
1987
29
Langerhans cells in the dermal infiltrate of hyperkeratosis lenticularis perstans. ( 3804548 )
1986
30
Hyperkeratosis lenticularis perstans: report on three cases. ( 2420130 )
1985
31
Familial hyperkeratosis lenticularis perstans. Associated with cancers of the digestive organs. ( 6392388 )
1984
32
Hyperkeratosis lenticularis perstans (Flegel's disease). ( 6195872 )
1983
33
Biochemical analyses of stratum corneum in hyperkeratosis lenticularis perstans. ( 6188769 )
1982
34
Dyskeratotic process of hyperkeratosis lenticularis perstans (Flegel). The abnormal formation of cystine-rich protein. ( 7117641 )
1982
35
Retinoid acid in the treatment of hyperkeratosis lenticularis perstans Flegel. ( 6175154 )
1982
36
Treatment of hyperkeratosis lenticularis perstans (Flegel) with topical fluorouracil. ( 7364143 )
1980
37
Hyperkeratosis lenticularis perstans (Flegel). ( 7439482 )
1980
38
An ultrastructural study of the epidermis in hyperkeratosis lenticularis perstans. ( 82336 )
1978
39
Intracytoplasmic inclusions in dermal infiltrating cells of hyperkeratosis lenticularis perstans. ( 588458 )
1977
40
Hyperkeratosis lenticularis perstans (Flegel). A biological model for keratinization occurring in the absence of odland bodies? ( 65301 )
1976
41
Hyperkeratosis lenticularis perstans (Flegel). ( 4140664 )
1974
42
Letter: Hyperkeratosis lenticularis perstans. ( 4451399 )
1974
43
Hyperkeratosis lenticularis perstans (Flegel). An autosomal dominant skin disease due to lack of a keratinocytic organelle. ( 4430495 )
1974
44
Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. ( 4715122 )
1973
45
The genetics of hyperkeratosis lenticularis perstans. ( 5039109 )
1972
46
Coexistence of hyperkeratosis lenticularis perstans (Flegel) and hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle) in a patient. ( 4099145 )
1970
47
Hyperkeratosis lenticularis perstans. ( 5358103 )
1969
48
Hyperkeratosis lenticularis perstans. A clinical, histopathologic, and genetic study. ( 5783081 )
1969
49
Hyperkeratosis lenticularis perstans (Flegel). ( 5642681 )
1968
50
Hyperkeratosis lenticularis perstans (Flegel) or dyskeratotic psoriasiform dermatosis. A single dermatosis or two? ( 5673884 )
1968

Variations for Hyperkeratosis Lenticularis Perstans

Expression for Hyperkeratosis Lenticularis Perstans

Search GEO for disease gene expression data for Hyperkeratosis Lenticularis Perstans.

Pathways for Hyperkeratosis Lenticularis Perstans

GO Terms for Hyperkeratosis Lenticularis Perstans

Sources for Hyperkeratosis Lenticularis Perstans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....