HLP
MCID: HYP160
MIFTS: 27

Hyperkeratosis Lenticularis Perstans (HLP)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Hyperkeratosis Lenticularis Perstans

MalaCards integrated aliases for Hyperkeratosis Lenticularis Perstans:

Name: Hyperkeratosis Lenticularis Perstans 57 73 20 58 70
Flegel Disease 57 20 58
Hlp 57 20
Hyperkeratosis Lenticularis Perstans of Flegel 20
Flegel's Disease 20

Characteristics:

Orphanet epidemiological data:

58
hyperkeratosis lenticularis perstans
Inheritance: Autosomal dominant,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
hyperkeratosis lenticularis perstans:
Inheritance autosomal dominant inheritance
Onset and clinical course adult onset


Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

OMIM® 57 144150
MESH via Orphanet 45 C538377
UMLS via Orphanet 71 C0263420
Orphanet 58 ORPHA409
MedGen 41 C0263420
UMLS 70 C0263420

Summaries for Hyperkeratosis Lenticularis Perstans

OMIM® : 57 Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown keratotic papules that primarily affect the extremities. The disorder was first described by Flegel (1958) (summary by Bean, 1972). (144150) (Updated 20-May-2021)

MalaCards based summary : Hyperkeratosis Lenticularis Perstans, also known as flegel disease, is related to keratosis and hyperlipoproteinemia, type iii. An important gene associated with Hyperkeratosis Lenticularis Perstans is HLP (Hyperkeratosis Lenticularis Perstans). Affiliated tissues include skin and breast, and related phenotypes are papule and hyperkeratosis lenticularis perstans

Wikipedia : 73 Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis, or skin),... more...

Related Diseases for Hyperkeratosis Lenticularis Perstans

Diseases related to Hyperkeratosis Lenticularis Perstans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 keratosis 11.2
2 hyperlipoproteinemia, type iii 11.0
3 skin disease 10.5
4 dowling-degos disease 1 10.3
5 porokeratosis 10.3
6 erythrokeratoderma ''en cocardes'' 10.3
7 hypercholesterolemia, familial, 1 10.1
8 hypertriglyceridemia, familial 10.0
9 angina pectoris 10.0
10 exanthem 10.0
11 candida glabrata 10.0
12 kyrle disease 10.0
13 leprosy 3 9.9
14 familial hyperlipidemia 9.9
15 acute pancreatitis 9.9
16 crohn's disease 9.9
17 cytokine deficiency 9.9
18 hansen's disease 9.9
19 anoxia 9.9

Graphical network of the top 20 diseases related to Hyperkeratosis Lenticularis Perstans:



Diseases related to Hyperkeratosis Lenticularis Perstans

Symptoms & Phenotypes for Hyperkeratosis Lenticularis Perstans

Human phenotypes related to Hyperkeratosis Lenticularis Perstans:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 papule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200034
2 hyperkeratosis lenticularis perstans 58 31 hallmark (90%) Very frequent (99-80%) HP:0007570
3 skin ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0200042
4 pruritus 58 31 frequent (33%) Frequent (79-30%) HP:0000989
5 aplasia/hypoplasia of the skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0008065
6 basal cell carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0002671
7 squamous cell carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0002860

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Skin:
hyperkeratosis lenticularis perstans
hyperkeratotic pink or reddish-brown scaly 1 to 5 mm papules of lower leg and dorsum of foot

Misc:
lesions of trunk, thigh, arms and dorsum of the hand may occur
onset in third or fourth decade

Clinical features from OMIM®:

144150 (Updated 20-May-2021)

Drugs & Therapeutics for Hyperkeratosis Lenticularis Perstans

Search Clinical Trials , NIH Clinical Center for Hyperkeratosis Lenticularis Perstans

Genetic Tests for Hyperkeratosis Lenticularis Perstans

Anatomical Context for Hyperkeratosis Lenticularis Perstans

MalaCards organs/tissues related to Hyperkeratosis Lenticularis Perstans:

40
Skin, Breast

Publications for Hyperkeratosis Lenticularis Perstans

Articles related to Hyperkeratosis Lenticularis Perstans:

(show top 50) (show all 74)
# Title Authors PMID Year
1
Hyperkeratosis lenticularis perstans (Flegel). An autosomal dominant skin disease due to lack of a keratinocytic organelle. 57 61
4430495 1974
2
Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. 61 57
4715122 1973
3
The genetics of hyperkeratosis lenticularis perstans. 61 57
5039109 1972
4
Hyperkeratosis lenticularis perstans. A clinical, histopathologic, and genetic study. 57 61
5783081 1969
5
Hyperkeratosis lenticularis perstans (Flegel's disease): our experience and review of the literature. 61
32403156 2021
6
Dermoscopy of hyperkeratosis lenticularis perstans (Flegel disease). 61
30802320 2019
7
Postinflammatory hyperpigmentation following treatment of hyperkeratosis lenticularis perstans with tazarotene cream 0.1. 61
31603977 2019
8
Hyperkeratosis lenticularis perstans bei einem Patienten mit primärem Hyperaldosteronismus. 61
29314694 2018
9
Hyperkeratosis lenticularis perstans in a patient with primary hyperaldosteronism. 61
29232039 2018
10
Dermoscopic findings in hyperkeratosis lenticularis perstans. 61
27846965 2016
11
Detection of Borrelia burgdorferi sensu stricto and Borrelia garinii DNAs in patient with Hyperkeratosis lenticularis perstans (Flegel disease). 61
26769152 2016
12
A case of localized, unilateral hyperkeratosis lenticularis perstans on a woman's breast. 61
27027755 2016
13
A Case of Infantile Kyrle-Flegel Disease in a 6-Year-Old Yemeni Girl. 61
26933407 2016
14
Hyperkeratosis lenticularis perstans: case report of a rare entity. 61
23716839 2013
15
Photoletter to the editor: Hyperkeratosis lenticularis perstans (Flegel's disease) with unusual clinical presentation. Response to isotretinoin therapy. 61
23091588 2012
16
Hyperkeratosis lenticularis perstans. 61
22068777 2011
17
[Hyperkeratosis lenticularis perstans, or Flegel disease, with palmoplantar involvement]. 61
19445887 2009
18
Morphological evidence of periodical exacerbation of hyperkeratosis lenticularis perstans. 61
19386211 2009
19
Hyperkeratosis lenticularis perstans (Flegel's disease) - successful treatment with topical corticosteroids. 61
18986485 2008
20
Long-standing spiny papules on the lower extremities. Flegel disease, or hyperkeratosis lenticularis perstans (HLP). 61
19015429 2008
21
Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans (Flegel's disease). 61
16625073 2006
22
An unusual generalized form of hyperkeratosis lenticularis perstans (Flegel's disease). 61
15506318 2004
23
Case 3: widespread scaly papules affecting a patient's limbs and pinnae giving the skin a rough feeling. Diagnosis: Flegel's disease. Syn. hyperkeratosis lenticularis perstans. 61
12780736 2003
24
[Atypical acral hyperkeratosis in a black woman]. 61
12038187 2002
25
[40 years to Flegel's disease (hyperkeratosis lenticularis perstans)]. 61
11284069 2001
26
Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol. 61
11385235 2001
27
[Hyperkeratosis lenticularis perstans (Flegel's disease) - a complex disorder of epidermal differentiation with good response to a synthetic vitamin D3 derivate]. 61
10663037 2000
28
Hyperkeratosis lenticularis perstans (Flegel's disease): histologic, immunohistochemical, and ultrastructural features in a case. 61
10446786 1999
29
Unilateral hyperkeratosis lenticularis perstans (Flegel's disease). 61
9777782 1998
30
Multiple asymptomatic hyperkeratotic papules on the lower part of the legs. Hyperkeratosis lenticularis perstans (HLP) (Flegel disease). 61
9236534 1997
31
Hyperkeratosis lenticularis perstans (Flegel's disease). Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. 61
1469133 1992
32
Localized hyperkeratosis lenticularis perstans (Flegel's disease). 61
1935248 1991
33
[Hyperkeratosis lenticularis perstans. A clinical case and review of the literature]. 61
2279758 1990
34
[Hyperkeratosis lenticularis perstans (Flegel)]. 61
2695721 1989
35
Hyperkeratosis lenticularis perstans. 61
3360552 1988
36
Hyperkeratosis lenticularis perstans (Flegel's disease). In situ characterization of T cell subsets and Langerhans' cells. 61
2459881 1988
37
Lamellar bodies in hyperkeratosis lenticularis perstans. 61
3624584 1987
38
A clinicopathological study of Flegel's disease (hyperkeratosis lenticularis perstans). 61
2439113 1987
39
Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review. 61
3819050 1987
40
Hyperkeratosis lenticularis perstans (Flegel's disease). A light and electron microscopic study of involved and uninvolved epidermis. 61
3556701 1987
41
Langerhans cells in the dermal infiltrate of hyperkeratosis lenticularis perstans. 61
3804548 1986
42
[Tigason in hyperkeratosis lenticularis perstans (HLP)--a case report]. 61
3962407 1986
43
[Hyperkeratosis lenticularis perstans (Flegel's disease)]. 61
4008255 1985
44
Hyperkeratosis lenticularis perstans: report on three cases. 61
2420130 1985
45
Familial hyperkeratosis lenticularis perstans. Associated with cancers of the digestive organs. 61
6392388 1984
46
[Scanning electron microscopic observation of hyperkeratosis lenticularis perstans]. 61
6492450 1984
47
[Considerations on a case of hyperkeratosis lenticularis perstans]. 61
6671693 1983
48
Hyperkeratosis lenticularis perstans (Flegel's disease). 61
6195872 1983
49
Biochemical analyses of stratum corneum in hyperkeratosis lenticularis perstans. 61
6188769 1982
50
Dyskeratotic process of hyperkeratosis lenticularis perstans (Flegel). The abnormal formation of cystine-rich protein. 61
7117641 1982

Variations for Hyperkeratosis Lenticularis Perstans

Expression for Hyperkeratosis Lenticularis Perstans

Search GEO for disease gene expression data for Hyperkeratosis Lenticularis Perstans.

Pathways for Hyperkeratosis Lenticularis Perstans

GO Terms for Hyperkeratosis Lenticularis Perstans

Sources for Hyperkeratosis Lenticularis Perstans

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
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28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
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53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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