CAD
MCID: HYP724
MIFTS: 62
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Hyperlipoproteinemia, Type Iii (CAD)
Categories:
Endocrine diseases, Genetic diseases, Liver diseases, Metabolic diseases, Rare diseases
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MalaCards integrated aliases for Hyperlipoproteinemia, Type Iii:
Characteristics:Orphanet epidemiological data:59
hyperlipoproteinemia type 3
Inheritance: Autosomal dominant,Multigenic/multifactorial; Prevalence: 1-5/10000 (Worldwide); Age of onset: All ages; Age of death: normal life expectancy; Classifications:
MalaCards categories:
Global: Genetic diseases Metabolic diseases Rare diseases Anatomical: Endocrine diseases Liver diseases
ICD10:
34
External Ids:
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UniProtKB/Swiss-Prot
:
75
Coronary artery disease: A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction. Hyperlipoproteinemia 3: A disorder characterized by the accumulation of intermediate-density lipoprotein particles (IDL or broad-beta-lipoprotein) rich in cholesterol. Clinical features include xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause.
MalaCards based summary : Hyperlipoproteinemia, Type Iii, also known as hyperlipoproteinemia type iii, is related to hyperlipoproteinemia, type iv and atherosclerosis susceptibility, and has symptoms including tremor, angina pectoris and edema. An important gene associated with Hyperlipoproteinemia, Type Iii is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs Pravastatin and Fenofibrate have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and lung, and related phenotypes are obesity and diabetes mellitus OMIM : 57 Hyperlipoproteinemia type III, also called dysbetalipoproteinemia, is characterized by hyperlipidemia due to accumulation of remnants of the triglyceride (TG)-rich lipoproteins (TGRL), very low density lipoproteins (VLDL), and chylomicrons (CM), in response to dysfunctional genetic variants of apolipoprotein E or absence of apoE (summary by Blum, 2016). (617347) Wikipedia : 76 Familial dysbetalipoproteinemia or type III hyperlipoproteinemia (also known as remnant hyperlipidemia,... more... |
Human phenotypes related to Hyperlipoproteinemia, Type Iii:59 32 (show all 28)
UMLS symptoms related to Hyperlipoproteinemia, Type Iii:tremor, angina pectoris, edema, chest pain, equilibration disorder, substernal pain GenomeRNAi Phenotypes related to Hyperlipoproteinemia, Type Iii according to GeneCards Suite gene sharing:26
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Drugs for Hyperlipoproteinemia, Type Iii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 11)
Interventional clinical trials:
Inferred drug relations via UMLS 73 / NDF-RT 51 :Cochrane evidence based reviews: hyperlipoproteinemia type iii |
MalaCards organs/tissues related to Hyperlipoproteinemia, Type Iii:41
Heart,
Liver,
Lung,
Skin,
Brain,
Kidney,
Bone
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Articles related to Hyperlipoproteinemia, Type Iii:
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UniProtKB/Swiss-Prot genetic disease variations for Hyperlipoproteinemia, Type Iii:75
ClinVar genetic disease variations for Hyperlipoproteinemia, Type Iii:6 (show all 33)
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Search
GEO
for disease gene expression data for Hyperlipoproteinemia, Type Iii.
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Pathways related to Hyperlipoproteinemia, Type Iii according to GeneCards Suite gene sharing:(show all 14)
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Cellular components related to Hyperlipoproteinemia, Type Iii according to GeneCards Suite gene sharing:(show all 13)
Biological processes related to Hyperlipoproteinemia, Type Iii according to GeneCards Suite gene sharing:(show top 50) (show all 51)
Molecular functions related to Hyperlipoproteinemia, Type Iii according to GeneCards Suite gene sharing:(show all 18)
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