Aliases & Classifications for Hyperlucent Lung

MalaCards integrated aliases for Hyperlucent Lung:

Name: Hyperlucent Lung 12 15
Lung, Hyperlucent 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10032
MeSH 44 D019568
UMLS 73 C0524799

Summaries for Hyperlucent Lung

MalaCards based summary : Hyperlucent Lung, also known as lung, hyperlucent, is related to mitral valve disease and bronchiolitis, and has symptoms including hemoptysis An important gene associated with Hyperlucent Lung is FBXW7 (F-Box And WD Repeat Domain Containing 7), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include lung and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hyperlucent Lung

Diseases related to Hyperlucent Lung via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 mitral valve disease 29.2 IL10 IL4
2 bronchiolitis 28.6 IFNG IL10 IL4
3 posterior uveitis 10.4 IFNG IL2RA
4 hypersplenism 10.4 IFNG IL2RA
5 swyer-james syndrome 10.3
6 eumycotic mycetoma 10.3 IFNG NELFCD
7 radiculopathy 10.2 IL10 IL2RA
8 ascaridiasis 10.2 IL10 NELFCD
9 sporotrichosis 10.2 IFNG IL10
10 idiopathic neutropenia 10.2 IL10 IL2RA
11 tuberculoid leprosy 10.2 IFNG IL10
12 clonorchiasis 10.2 IFNG IL10
13 chronic active epstein-barr virus infection 10.2 IFNG IL10
14 multicentric castleman disease 10.2 IFNG IL10
15 fascioliasis 10.2 IFNG IL10
16 hand, foot and mouth disease 10.2 IFNG IL10
17 pulmonary sarcoidosis 10.2 IFNG IL2RA
18 peanut allergy 10.2 IFNG IL10
19 hemorrhagic fever 10.2 IFNG IL10
20 spotted fever 10.2 IFNG IL10
21 hematopoietic stem cell transplantation 10.1 IFNG IL10
22 aseptic meningitis 10.1 IFNG IL10
23 primary peritoneal carcinoma 10.1 IFNG IL10
24 plasmodium vivax malaria 10.1 IFNG IL10
25 primary sjögren syndrome 10.1 IL10 IL2RA
26 q fever 10.1 IFNG IL10
27 polyradiculoneuropathy 10.1 IFNG IL10
28 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 IFNG IL10
29 pneumonia 10.1
30 extrapulmonary tuberculosis 10.1 IFNG IL10
31 lepromatous leprosy 10.1 IFNG IL10
32 extrinsic allergic alveolitis 10.1 IL10 IL2RA
33 herpes zoster 10.1 IFNG IL10
34 mixed connective tissue disease 10.1 IFNG IL10
35 echinococcosis 10.1 IFNG IL10
36 reactive arthritis 10.1 IFNG IL10
37 melioidosis 10.1 IFNG IL10
38 vogt-koyanagi-harada disease 10.1 IL10 IL2RA
39 alopecia areata 10.1 IFNG IL2RA
40 dengue hemorrhagic fever 10.1 IFNG IL10
41 human immunodeficiency virus infectious disease 10.0 IFNG IL10
42 lymphopenia 10.0 IFNG IL2RA
43 filariasis 10.0 IFNG IL10
44 mycoplasmal pneumonia 10.0 IFNG IL4
45 bronchiolitis obliterans 10.0 IFNG IL10
46 b-cell growth factor 10.0 IFNG IL4
47 lymphadenitis 10.0 IFNG IL10
48 penicillin allergy 10.0 IFNG IL4
49 atopic keratoconjunctivitis 10.0 IFNG IL4
50 microscopic colitis 9.9 IFNG IL4

Graphical network of the top 20 diseases related to Hyperlucent Lung:



Diseases related to Hyperlucent Lung

Symptoms & Phenotypes for Hyperlucent Lung

UMLS symptoms related to Hyperlucent Lung:


hemoptysis

GenomeRNAi Phenotypes related to Hyperlucent Lung according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.92 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.92 IL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.92 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.92 FBXW7 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.92 FBXW7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.92 IL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.92 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.92 IL2RA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.92 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.92 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.92 FBXW7 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.92 FBXW7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.92 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.92 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.92 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.92 FBXW7
17 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.92 FBXW7
18 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.92 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.92 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.92 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.92 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.92 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.92 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 IL10
25 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.92 IL2RA IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.92 FBXW7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.92 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.92 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.92 IL10 FBXW7 IL2RA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.92 IL10 IL2RA
31 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.92 IL10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.92 IL10
33 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.92 IL10
34 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.92 IL2RA

MGI Mouse Phenotypes related to Hyperlucent Lung:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.72 IL10 IL2RA IL4 FBXW7 IFNG
2 craniofacial MP:0005382 9.67 IL10 IL4 FBXW7 IFNG
3 endocrine/exocrine gland MP:0005379 9.65 IL10 IL2RA IL4 FBXW7 IFNG
4 liver/biliary system MP:0005370 9.46 IL10 IL4 FBXW7 IFNG
5 respiratory system MP:0005388 9.35 IL10 IL2RA IL4 FBXW7 IFNG
6 vision/eye MP:0005391 9.02 IL10 IL2RA IL4 FBXW7 IFNG

Drugs & Therapeutics for Hyperlucent Lung

Drugs for Hyperlucent Lung (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
2 tannic acid Approved, Nutraceutical Phase 4
3 Calamus Nutraceutical Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD Completed NCT01377818 Phase 4

Search NIH Clinical Center for Hyperlucent Lung

Cochrane evidence based reviews: lung, hyperlucent

Genetic Tests for Hyperlucent Lung

Anatomical Context for Hyperlucent Lung

MalaCards organs/tissues related to Hyperlucent Lung:

41
Lung, Kidney

Publications for Hyperlucent Lung

Articles related to Hyperlucent Lung:

(show top 50) (show all 70)
# Title Authors Year
1
A unilateral hyperlucent lung - Swyer-James syndrome: A case report and literature review. ( 28138424 )
2017
2
Unilateral hyperlucent lung. ( 26933332 )
2016
3
Asymptomatic Unilateral Hyperlucent Lung in a Prospective Kidney Donor. ( 27608883 )
2015
4
Unilateral hyperlucent lung: An unusual cause. ( 26628784 )
2015
5
Unilateral hyperlucent lung associated with bronchial atresia mimicking swyer-james syndrome. ( 25053829 )
2014
6
A case of unilateral hyperlucent lung. ( 24575998 )
2014
7
Unilateral hyperlucent lung: Always think ACROSS. ( 24339504 )
2013
8
Differential diagnosis of unilateral hyperlucent lung in children. ( 23255778 )
2013
9
Unilateral hyperlucent lung in a child caused by a foreign body identified with v/q scintigraphy. ( 22889792 )
2012
10
Unilateral hyperlucent lung in children. ( 22528920 )
2012
11
Collateral ventilation to congenital hyperlucent lung lesions assessed on xenon-enhanced dynamic dual-energy CT: an initial experience. ( 21228937 )
2011
12
Usefulness of combination of pulmonary ventilation and perfusion scintigraphy on the diagnosis of children with unilateral hyperlucent lung. ( 21869729 )
2011
13
Diagnostic approach to unilateral hyperlucent lung. ( 22279605 )
2011
14
Swyer-James-MacLeod syndrome with ipsilateral herniation of hyperinflated hyperlucent lung. ( 22679043 )
2011
15
Bronchial adenoid cystic carcinoma presenting as unilateral hyperlucent lung (Swyer-James-McLeod syndrome). ( 18157603 )
2007
16
Unilateral hyperlucent lung: MacLeod versus Swyer-James. ( 15488856 )
2004
17
An extrathoracic cause for a unilateral hyperlucent lung on a chest radiograph. ( 14732797 )
2003
18
Utility of ventilation and perfusion scan in the diagnosis of young military recruits with an incidental finding of hyperlucent lung. ( 11388574 )
2001
19
Mediastinal esophageal cyst causing unilateral hyperlucent lung. ( 10226415 )
1999
20
Hyperlucent lung in a patient with mitral valve disease. ( 9824031 )
1998
21
Hyperlucent lung secondary to homocystinuria. ( 8781109 )
1996
22
Scintigraphy, angiography and computed tomography in unilateral hyperlucent lung due to obliterative bronchiolitis. ( 7824812 )
1994
23
Congenital pulmonary lymphangiectasis presenting as a unilateral hyperlucent lung. ( 8181508 )
1994
24
A patient with a chronic cough and one hyperlucent lung. ( 1541644 )
1992
25
A case report of unilateral hyperlucent lung syndrome. ( 1890083 )
1991
26
Transient unilateral hyperlucent lung due to mucus plugs. ( 1865034 )
1991
27
Presentation of bronchial mucoepidermoid carcinoma as unilateral hyperlucent lung. ( 2371078 )
1990
28
Ventilation-perfusion scintigraphy in an adult with congenital unilateral hyperlucent lung. ( 2225670 )
1990
29
Idiopathic unilateral hyperlucent lung. ( 2666886 )
1989
30
Unilateral hyperlucent lung due to interstitial pulmonary hemorrhage from aortic dissection. ( 2913792 )
1989
31
Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung. ( 3260171 )
1988
32
Ventilation-perfusion scan in the acutely ill patient with unilateral hyperlucent lung. ( 3335918 )
1988
33
Hyperlucent lung due to a calcium-containing bronchogenic cyst. ( 3243755 )
1988
34
Unilateral hyperlucent lung due to bullous disease. ( 3743158 )
1986
35
Swyer-James syndrome--unilateral hyperlucent lung syndrome. A case report and review. ( 6723187 )
1984
36
Hyperlucent lung: long-term complication of adenovirus type 7 pneumonia. ( 6291737 )
1983
37
Chronic unilateral hyperlucent lung. A consecutive series of 40 patients. ( 6212408 )
1982
38
Unilateral hyperlucent lung. Non-invasive diagnosis of pulmonary artery agenesis. ( 7224230 )
1981
39
Unilateral hyperlucent lung: the case for investigation. ( 7466723 )
1980
40
The unilateral hyperlucent lung. ( 7360420 )
1980
41
A case of hyperlucent lung. ( 470052 )
1979
42
Unilateral hyperlucent lung. Patent ductus arteriosus coexisting with bronchial carcinoid. ( 223818 )
1979
43
Unilateral hyperlucent lung (Swyer-James syndrome) after severe Mycoplasma pneumoniae infection. ( 619715 )
1978
44
Unilateral hyperlucent lung associated to mitral regurgitation. ( 889471 )
1977
45
Unilateral hyperlucent lung field in subcutaneous emphysema. ( 975967 )
1976
46
Unilateral hyperlucent lung with decreased vascular markings (Swyer-James syndrome). ( 1124208 )
1975
47
Swyer-James syndrome: a cause of hyperlucent lung. ( 1190675 )
1975
48
Hyperlucent lung after radiation therapy. ( 1155850 )
1975
49
Unilateral hyperlucent lung (Swyer-James syndrome). ( 1181658 )
1975
50
Hyperlucent lung. Pathophysiology and surgical management. ( 4621032 )
1974

Variations for Hyperlucent Lung

Expression for Hyperlucent Lung

Search GEO for disease gene expression data for Hyperlucent Lung.

Pathways for Hyperlucent Lung

Pathways related to Hyperlucent Lung according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 IFNG IL10 IL2RA IL4
2
Show member pathways
13.03 IFNG IL10 IL2RA IL4
3
Show member pathways
12.58 IFNG IL10 IL2RA IL4
4
Show member pathways
12.5 IFNG IL2RA IL4
5
Show member pathways
12.33 IFNG IL10 IL2RA IL4
6 12.27 IFNG IL10 IL2RA IL4
7
Show member pathways
12.16 IFNG IL10 IL4
8
Show member pathways
12.13 IFNG IL10 IL2RA IL4
9
Show member pathways
12 IFNG IL10 IL4
10
Show member pathways
11.81 IFNG IL10 IL2RA IL4
11
Show member pathways
11.74 IFNG IL2RA IL4
12 11.64 IFNG IL10 IL2RA
13
Show member pathways
11.53 IFNG IL2RA IL4
14 11.52 IFNG IL10 IL2RA IL4
15 11.5 IFNG IL10
16
Show member pathways
11.45 IL2RA IL4
17 11.42 IL10 IL4
18
Show member pathways
11.4 IFNG IL2RA
19 11.3 IL10 IL4
20 11.29 IFNG IL10
21 11.16 IFNG IL10 IL2RA IL4
22 11.14 IFNG IL10
23 11.09 IFNG IL4
24 11.06 IFNG IL2RA IL4
25
Show member pathways
11.03 IFNG IL2RA
26 11 IFNG IL2RA
27 10.97 IFNG IL10 IL4
28 10.85 IFNG IL10 IL4
29 10.59 IFNG IL10 IL2RA IL4

GO Terms for Hyperlucent Lung

Biological processes related to Hyperlucent Lung according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.69 IFNG IL10 IL4
2 cytokine-mediated signaling pathway GO:0019221 9.63 IL10 IL2RA IL4
3 immune response GO:0006955 9.56 IFNG IL10 IL2RA IL4
4 B cell differentiation GO:0030183 9.52 IL10 IL4
5 positive regulation of T cell proliferation GO:0042102 9.49 IL2RA IL4
6 interleukin-12-mediated signaling pathway GO:0035722 9.48 IFNG IL10
7 negative regulation of T cell proliferation GO:0042130 9.43 IL10 IL2RA
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.4 IL10 IL4
9 positive regulation of T cell differentiation GO:0045582 9.37 IL2RA IL4
10 regulation of regulatory T cell differentiation GO:0045589 9.32 IFNG IL2RA
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IL10 IL4
12 type 2 immune response GO:0042092 8.96 IL10 IL4
13 regulation of isotype switching GO:0045191 8.62 IL10 IL4

Molecular functions related to Hyperlucent Lung according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNG IL10 IL4

Sources for Hyperlucent Lung

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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