MCID: HYP007
MIFTS: 37

Hypermobility Syndrome

Categories: Bone diseases

Aliases & Classifications for Hypermobility Syndrome

MalaCards integrated aliases for Hypermobility Syndrome:

Name: Hypermobility Syndrome 12 55 15 73
Benign Joint Hypermobility 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13781
ICD10 33 M35.7
ICD9CM 35 728.5
SNOMED-CT 68 85551004
UMLS 73 C0152093

Summaries for Hypermobility Syndrome

MalaCards based summary : Hypermobility Syndrome, also known as benign joint hypermobility, is related to ehlers-danlos syndrome and classic ehlers-danlos syndrome. An important gene associated with Hypermobility Syndrome is TNXB (Tenascin XB), and among its related pathways/superpathways are Collagen chain trimerization and Focal Adhesion. The drugs Phenylephrine and Oxymetazoline have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin.

Wikipedia : 76 Hypermobility, also known as double-jointedness, describes joints that stretch farther than normal. For... more...

Related Diseases for Hypermobility Syndrome

Diseases related to Hypermobility Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 ehlers-danlos syndrome 30.6 C1R COL3A1 COL5A1 TNXB
2 classic ehlers-danlos syndrome 29.7 COL5A1 TNXB
3 marfanoid hypermobility syndrome 12.3
4 ehlers-danlos syndrome, hypermobility type 11.7
5 hypermobile ehlers-danlos syndrome 11.6
6 joint laxity, familial 11.3
7 marfan syndrome 11.0
8 hypermobility of coccyx 11.0
9 anxiety 10.1
10 orthostatic intolerance 10.1
11 ehlers-danlos syndrome, vascular type 10.0 COL3A1 COL5A1
12 ehlers-danlos syndrome, classic type, 2 10.0 COL3A1 COL5A1
13 postural orthostatic tachycardia syndrome 10.0
14 arthropathy 10.0
15 panic disorder 10.0
16 pain - chronic 10.0
17 tarsal tunnel syndrome 10.0
18 neuropathy 10.0
19 pelvic organ prolapse 10.0 COL3A1 TNXB
20 ehlers-danlos syndrome, classic type, 1 10.0 COL3A1 COL5A1
21 celiac disease 1 9.9
22 arthritis 9.9
23 inguinal hernia 9.9
24 dystonia 9.9
25 dysautonomia 9.9
26 collagen disease 9.9 COL3A1 COL5A1 TNXB
27 brittle bone disorder 9.9 COL3A1 PEPD
28 connective tissue disease 9.9 COL3A1 COL5A1 TNXB
29 carpal tunnel syndrome 9.8
30 systemic lupus erythematosus 9.8
31 pectus excavatum 9.8
32 rheumatoid arthritis 9.8
33 asthma 9.8
34 mononeuropathy of the median nerve, mild 9.8
35 osteoarthritis 9.8
36 cervical dystonia 9.8
37 obsessive-compulsive personality disorder 9.8
38 von willebrand's disease 9.8
39 personality disorder 9.8
40 hyperostosis 9.8
41 diffuse idiopathic skeletal hyperostosis 9.8
42 chronic fatigue syndrome 9.8
43 lupus erythematosus 9.8
44 developmental coordination disorder 9.8
45 aortic coarctation 9.8
46 wandering spleen 9.8
47 fibromyalgia 9.8
48 developmental dyspraxia 9.8
49 dysphagia 9.8

Graphical network of the top 20 diseases related to Hypermobility Syndrome:



Diseases related to Hypermobility Syndrome

Symptoms & Phenotypes for Hypermobility Syndrome

Drugs & Therapeutics for Hypermobility Syndrome

Drugs for Hypermobility Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenylephrine Approved 59-42-7 6041
2
Oxymetazoline Approved, Investigational 1491-59-4 4636
3
Isoproterenol Approved, Investigational 7683-59-2 3779
4
Ephedrine Approved 299-42-3 9294
5
Pseudoephedrine Approved 90-82-4 7028
6 Vasoconstrictor Agents
7 Anti-Asthmatic Agents
8 Neurotransmitter Agents
9 Mydriatics
10 Adrenergic beta-Agonists
11 Nasal Decongestants
12 Immunoglobulins
13 Antibodies
14 Adrenergic alpha-Agonists
15 Adrenergic Agonists
16 Autonomic Agents
17 Adrenergic Agents
18 Sympathomimetics
19 Cardiotonic Agents
20 Respiratory System Agents
21 Peripheral Nervous System Agents
22 Protective Agents
23 Bronchodilator Agents
24 Immunologic Factors

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Spinal Stabilization Exercise Effects in Hypermobility Completed NCT02869373 Phase 2
2 A Study to Assess Benign Joint Hypermobility Syndrome in Children With a History of Wheezing or Asthma Completed NCT02163096
3 Resistance Training for Patients With Hypermobility Spectrum Disorders and Shoulder Symptoms: a Feasibility Study Completed NCT03547570 Not Applicable
4 Association Between Hypermobility and Chronic Musculoskeletal Pain Completed NCT01032863
5 Pelvic Floor Muscle Training (PFMT) in Treatment and Prevention of POP (POP Study) Completed NCT00271297 Not Applicable
6 The Comorbidity of Benign Hypermobility Joint Syndrome and Functional Constipation in Children Recruiting NCT02854098
7 Prevalence of FODMAP Intolerance and JHS in FGID and Association With Microbiome, Dyssynergic Defecation and Dietary Intervention Recruiting NCT03460613 Not Applicable
8 Genetics of Ehlers-Danlos Syndrome Recruiting NCT03093493
9 POTS Adrenergic Ab (CIHR Aims #1&2) Recruiting NCT02673996 Phenylephrine;Isoproterenol
10 Comparison of Exercise Therapies for Patellofemoral Pain Recruiting NCT03069547 Not Applicable
11 Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients Active, not recruiting NCT02761928
12 Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome Active, not recruiting NCT02196376
13 Gait Retraining in Patients With Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome Not yet recruiting NCT03575182 Not Applicable

Search NIH Clinical Center for Hypermobility Syndrome

Genetic Tests for Hypermobility Syndrome

Anatomical Context for Hypermobility Syndrome

MalaCards organs/tissues related to Hypermobility Syndrome:

41
Bone, Testes, Skin, Heart, Spleen

Publications for Hypermobility Syndrome

Articles related to Hypermobility Syndrome:

(show top 50) (show all 248)
# Title Authors Year
1
A novel surgical correction and innovative splint for swan neck deformity in hypermobility syndrome. ( 29915767 )
2018
2
COL1A1 Mutations Presenting as Descending Perineum Syndrome in a Young Patient With Hypermobility Syndrome. ( 29502568 )
2018
3
Evaluating the immediate effects of wearing foot orthotics in children with Joint Hypermobility Syndrome (JHS) by analysis of temperospatial parameters of gait and dynamic balance: A preliminary study. ( 29156379 )
2018
4
Focal linear elastosis in a patient with joint hypermobility syndrome. ( 29469764 )
2018
5
Prevalence and frequency of self-perceived systemic features in people with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type. ( 30232714 )
2018
6
Comment on: The multisystemic nature and natural history of joint hypermobility syndrome and Ehlers-Danlos syndrome in children. ( 30239925 )
2018
7
Comment on: The multisystemic nature and natural history of joint hypermobility syndrome and Ehlers-Danlos syndrome in children: reply. ( 30239979 )
2018
8
Interdisciplinary Pain Management Improves Pain and Function in Pediatric Patients with Chronic Pain Associated with Joint Hypermobility Syndrome. ( 30010052 )
2018
9
Generalized hypermobility syndrome (GHS) alters dynamic plantar pressure characteristics. ( 30412480 )
2018
10
The multisystemic nature and natural history of joint hypermobility syndrome and Ehlers-Danlos syndrome in children: New research data conflict with widely held views. ( 29106635 )
2017
11
Subjective health complaints and illness perception amongst adults with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome-HypermobilityType - a cross-sectional study. ( 29041819 )
2017
12
Exercise beliefs and behaviours of individuals with Joint Hypermobility syndrome/Ehlers-Danlos syndrome - hypermobility type. ( 29125009 )
2017
13
Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure? ( 28286774 )
2017
14
Coexistence of spondyloarthritis and joint hypermobility syndrome: rare or unknown association? ( 28933136 )
2017
15
A humanisation approach for the management of Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome-Hypermobility Type (JHS/EDS-HT). ( 28866967 )
2017
16
Mechanisms underlying reflux symptoms and dysphagia in patients with joint hypermobility syndrome, with and without postural tachycardia syndrome. ( 28191707 )
2017
17
Cognitive impairment in women with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type. ( 28180909 )
2017
18
Multiple fractures in infants who have Ehlers-Danlos/hypermobility syndrome and or vitamin D deficiency: A case series of 72 infants whose parents were accused of child abuse and neglect. ( 29511428 )
2017
19
The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome. ( 28306230 )
2017
20
Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers-Danlos syndrome - hypermobility type. ( 28482708 )
2017
21
Pregnancy outcome in joint hypermobility syndrome and Ehlers-Danlos syndrome. ( 27743500 )
2017
22
Effects of spinal stabilization exercises in women with benign joint hypermobility syndrome: a randomized controlled trial. ( 28361275 )
2017
23
Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: a review for the gastroenterologist. ( 28086259 )
2017
24
The natural history of children with joint hypermobility syndrome and Ehlers-Danlos hypermobility type: a longitudinal cohort study. ( 28431150 )
2017
25
Refining patterns of joint hypermobility, habitus, and orthopedic traits in joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type. ( 28266107 )
2017
26
Joint Hypermobility Syndrome: Recognizing a Commonly Overlooked Cause of Chronic Pain. ( 28286166 )
2017
27
Where do People with Joint Hypermobility Syndrome Present in Secondary Care? The Prevalence in a General Hospital and the Challenges of Classification. ( 27238954 )
2016
28
Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type. ( 26919608 )
2016
29
Generalized Hyperalgesia in children and adults diagnosed with Hypermobility Syndrome and Ehlers-Danlos Syndrome Hypermobility type: A discriminative analysis. ( 27483212 )
2016
30
Shoulder function, pain and health related quality of life in adults with joint hypermobility syndrome/Ehlers-Danlos syndrome-hypermobility type. ( 26824670 )
2016
31
Proteomic analysis for the identification of serum diagnostic markers for joint hypermobility syndrome. ( 26709396 )
2016
32
The feasibility of a randomised controlled trial of physiotherapy for adults with joint hypermobility syndrome. ( 27365226 )
2016
33
Quality of life, unmet needs, and iatrogenic injuries in rehabilitation of patients with Ehlers-Danlos Syndrome hypermobility type/Joint Hypermobility Syndrome. ( 27273746 )
2016
34
Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type. ( 27518164 )
2016
35
Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings. ( 27377649 )
2016
36
In Response to: Low Back Pain in Benign Joint Hypermobility Syndrome: Do not Forget the Adolescents. ( 27347870 )
2016
37
Nationwide population-based cohort study of celiac disease and risk of Ehlers-Danlos syndrome and joint hypermobility syndrome. ( 27321543 )
2016
38
Benign Joint Hypermobility Minimally Impacts Autonomic Abnormalities in Pediatric Subjects with Chronic Functional Pain Disorders. ( 27496265 )
2016
39
Difficulty eating and significant weight loss in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type. ( 26506923 )
2015
40
Physiotherapy management of joint hypermobility syndrome - a focus group study of patient and health professional perspectives. ( 26116487 )
2015
41
Living with joint hypermobility syndrome: patient experiences of diagnosis, referral and self-care. ( 25911504 )
2015
42
Diagnosis, Management and Assessment of Adults with Joint Hypermobility Syndrome: A UK-Wide Survey of Physiotherapy Practice. ( 25784539 )
2015
43
Spectrum of mucocutaneous manifestations in 277 patients with joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type. ( 25655071 )
2015
44
Re: Lower Urinary Tract Symptoms in Women with Benign Joint Hypermobility Syndrome: A Case-Control Study. ( 26195385 )
2015
45
A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type. ( 25791889 )
2015
46
Chronic pain in hypermobility syndrome and Ehlers-Danlos syndrome (hypermobility type): it is a challenge. ( 26316810 )
2015
47
The effects of neuromuscular taping on gait walking strategy in a patient with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type. ( 25649985 )
2015
48
Knowledge, assessment, and management of adults with joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type among flemish physiotherapists. ( 25821093 )
2015
49
Maxillofacial prosthetic rehabilitation for esophageal and laryngeal laxity due to the hypermobility syndrome: A clinical report. ( 25794916 )
2015
50
Prevalence, injury rate and, symptom frequency in generalized joint laxity and joint hypermobility syndrome in a "healthy" college population. ( 25930211 )
2015

Variations for Hypermobility Syndrome

Expression for Hypermobility Syndrome

Search GEO for disease gene expression data for Hypermobility Syndrome.

Pathways for Hypermobility Syndrome

GO Terms for Hypermobility Syndrome

Cellular components related to Hypermobility Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 C1R COL3A1 COL5A1 COL6A5 TNXB VTN
2 extracellular space GO:0005615 9.72 C1R COL3A1 COL5A1 TNXB VTN
3 basement membrane GO:0005604 9.37 COL5A1 VTN
4 collagen trimer GO:0005581 9.33 COL3A1 COL5A1 COL6A5
5 extracellular matrix GO:0031012 9.26 COL3A1 COL5A1 TNXB VTN
6 collagen-containing extracellular matrix GO:0062023 9.02 COL3A1 COL5A1 COL6A5 TNXB VTN

Biological processes related to Hypermobility Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.56 COL5A1 COL6A5 TNXB VTN
2 regulation of complement activation GO:0030449 9.43 C1R VTN
3 cell-matrix adhesion GO:0007160 9.4 COL3A1 VTN
4 blood vessel development GO:0001568 9.37 COL3A1 COL5A1
5 skin development GO:0043588 9.32 COL3A1 COL5A1
6 supramolecular fiber organization GO:0097435 9.16 COL3A1 COL5A1
7 collagen fibril organization GO:0030199 9.13 COL3A1 COL5A1 TNXB
8 extracellular matrix organization GO:0030198 8.92 COL3A1 COL5A1 TNXB VTN

Molecular functions related to Hypermobility Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.5 COL5A1 TNXB VTN
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.33 COL3A1 COL5A1 COL6A5
3 platelet-derived growth factor binding GO:0048407 9.26 COL3A1 COL5A1
4 integrin binding GO:0005178 9.26 COL3A1 COL5A1 TNXB VTN
5 extracellular matrix structural constituent GO:0005201 8.92 COL3A1 COL5A1 TNXB VTN

Sources for Hypermobility Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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