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MCID: HYP068
MIFTS: 52

Hyperostosis

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hyperostosis

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MalaCards integrated aliases for Hyperostosis:

Name: Hyperostosis 12 30 56 45 15 74
Hypertrophy of Bone 12
Bone Hypertrophy 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:205
MeSH 45 D015576
NCIt 51 C34712
SNOMED-CT 69 13814009
ICD10 34 M89.3 M89.30
UMLS 74 C0020492
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Summaries for Hyperostosis

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Disease Ontology : 12 A bone remodeling disease that results in an abnormal growth of located in bone.

MalaCards based summary : Hyperostosis, also known as hypertrophy of bone, is related to endosteal hyperostosis, autosomal dominant and tumoral calcinosis, hyperphosphatemic, familial, 1. An important gene associated with Hyperostosis is SOST (Sclerostin), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Senescence and Autophagy in Cancer. The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and brain, and related phenotypes are growth/size/body region and cellular

Wikipedia : 77 Hyperostosis is an excessive growth of bone. It may lead to exostosis. It occurs in many musculoskeletal... more...

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Related Diseases for Hyperostosis

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Diseases related to Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 endosteal hyperostosis, autosomal dominant 33.7 ANKH LRP5 TNFRSF11B
2 tumoral calcinosis, hyperphosphatemic, familial, 1 33.4 FGF23 GALNT3 KL
3 osteopathia striata with cranial sclerosis 33.4 LRP5 TNFRSF11B
4 caffey disease 33.4 COL1A1 GALNT3
5 sclerosteosis 1 33.1 LRP4 SOST
6 sclerosteosis 33.1 COL1A1 LRP4 LRP5 SOST
7 van buchem disease 32.9 COL1A1 KREMEN1 LRP4 LRP5 SOST
8 craniodiaphyseal dysplasia 32.4 LRP5 SOST TGFB1
9 sclerosteosis 2 32.2 LRP4 LRP5 SOST
10 hyperphosphatemia 30.5 FGF23 GALNT3 KL
11 familial tumoral calcinosis 30.2 FGF23 GALNT3 KL
12 calcinosis 30.0 ANKH FGF23 GALNT3 KL
13 renal osteodystrophy 30.0 FGF23 SOST TNFRSF11B
14 chondrocalcinosis 29.6 ALPL ANKH TNFRSF11B
15 facial paralysis 29.6 ANKH LRP5 TGFB1
16 bone disease 28.6 ALPL COL1A1 FGF23 IGF1 LRP5 SOST
17 osteoporosis 28.1 ALPL COL1A1 FGF23 IGF1 KL LRP5
18 diffuse idiopathic skeletal hyperostosis 12.7
19 hyperostosis cranialis interna 12.6
20 hyperostosis frontalis interna 12.6
21 calvarial hyperostosis 12.5
22 ankylosing vertebral hyperostosis with tylosis 12.5
23 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.4
24 polyosteolysis-hyperostosis syndrome 12.2
25 dysplastic cortical hyperostosis 12.2
26 sapho syndrome 12.1
27 short stature cranial hyperostosis hepatomegaly 12.0
28 short stature, cranial hyperostosis, hepatomegaly and diabetes 12.0
29 isolated sternocostoclavicular hyperostosis 12.0
30 paget disease of bone 5, juvenile-onset 11.8
31 camurati-engelmann disease 11.7
32 worth type autosomal dominant osteosclerosis 11.5
33 craniometaphyseal dysplasia, autosomal dominant 11.4
34 exostosis 11.3
35 lenz-majewski hyperostotic dwarfism 11.3
36 frontometaphyseal dysplasia 2 11.2
37 tumoral calcinosis, hyperphosphatemic, familial, 2 11.2
38 tumoral calcinosis, hyperphosphatemic, familial, 3 11.2
39 melorheostosis 11.1
40 weleber hecht bigley syndrome 11.1
41 craniodiaphyseal dysplasia, autosomal dominant 11.1
42 craniometaphyseal dysplasia, autosomal recessive 11.1
43 weismann-netter syndrome 10.9
44 melorheostosis, isolated 10.9
45 buschke-ollendorff syndrome 10.9
46 raine syndrome 10.9
47 ossification of the posterior longitudinal ligament of spine 10.9
48 synovitis 10.6
49 dysphagia 10.6
50 spondylitis 10.5

Graphical network of the top 20 diseases related to Hyperostosis:



Diseases related to Hyperostosis
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Symptoms & Phenotypes for Hyperostosis

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MGI Mouse Phenotypes related to Hyperostosis:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 ALPL ANKH COL1A1 COX4I2 FGF23 GALNT3
2 cellular MP:0005384 10.35 ALPL ANKH COL1A1 GALNT3 IGF1 KL
3 homeostasis/metabolism MP:0005376 10.32 ALPL ANKH COL1A1 COX4I2 FGF23 GALNT3
4 cardiovascular system MP:0005385 10.27 ALPL ANKH COL1A1 FGF23 GALNT3 IGF1
5 behavior/neurological MP:0005386 10.24 ALPL ANKH COL1A1 COX4I2 KL LRP4
6 limbs/digits/tail MP:0005371 10.22 ALPL ANKH COL1A1 FGF23 GALNT3 IGF1
7 craniofacial MP:0005382 10.21 ALPL ANKH COL1A1 GALNT3 KL LRP4
8 immune system MP:0005387 10.2 ALPL ANKH COL1A1 COX4I2 FGF23 GALNT3
9 endocrine/exocrine gland MP:0005379 10.19 ALPL COL1A1 FGF23 GALNT3 IGF1 KL
10 hematopoietic system MP:0005397 10.19 ALPL ANKH COL1A1 FGF23 GALNT3 IGF1
11 mortality/aging MP:0010768 10.11 ALPL ANKH COL1A1 FGF23 IGF1 KL
12 adipose tissue MP:0005375 10.07 ALPL COL1A1 IGF1 KL SLC39A14 TGFB1
13 digestive/alimentary MP:0005381 10.02 ALPL COL1A1 FGF23 GALNT3 KL TGFB1
14 integument MP:0010771 9.98 COL1A1 FGF23 GALNT3 IGF1 KL LRP4
15 muscle MP:0005369 9.92 ALPL ANKH COL1A1 GALNT3 IGF1 KL
16 hearing/vestibular/ear MP:0005377 9.91 ANKH COL1A1 IGF1 KL TNFRSF11B
17 reproductive system MP:0005389 9.85 ALPL ANKH COL1A1 FGF23 GALNT3 IGF1
18 renal/urinary system MP:0005367 9.8 COL1A1 FGF23 GALNT3 IGF1 KL LRP4
19 respiratory system MP:0005388 9.61 ALPL ANKH COL1A1 COX4I2 FGF23 IGF1
20 skeleton MP:0005390 9.47 ALPL ANKH COL1A1 FGF23 GALNT3 IGF1
Sources

Drugs & Therapeutics for Hyperostosis

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Drugs for Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
3
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
4
leucovorin Approved Phase 2 58-05-9 6006 143
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
8 Anti-Bacterial Agents Phase 2
9 Anti-Infective Agents Phase 2
10 Immunosuppressive Agents Phase 2
11 Immunologic Factors Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Antifungal Agents Phase 2
14 Dermatologic Agents Phase 2
15 Antirheumatic Agents Phase 2
16 Folic Acid Antagonists Phase 2
17 Nucleic Acid Synthesis Inhibitors Phase 2
18 Antibodies Phase 2
19 Antimetabolites, Antineoplastic Phase 2
20 Vitamin B9 Phase 2
21 Folate Phase 2
22 Antibodies, Monoclonal Phase 2
23 Antimetabolites Phase 2
24 Vitamin B Complex Phase 2
25 Immunoglobulins Phase 2
26
Pamidronate Approved Phase 1 40391-99-9 4674
27 Bone Density Conservation Agents Phase 1
28 Diphosphonates Phase 1
29
Sevelamer Approved 52757-95-6
30
Etanercept Approved, Investigational 185243-69-0
31
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
32 Nutrients
33 Vitamins
34 Trace Elements
35 Chelating Agents
36 Hydroxycholecalciferols
37 Micronutrients
38 Analgesics
39 Peripheral Nervous System Agents
40 Anti-Inflammatory Agents
41 Anti-Inflammatory Agents, Non-Steroidal
42 Analgesics, Non-Narcotic
43 Gastrointestinal Agents
44 Insulin, Globin Zinc Not Applicable
45 insulin Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
2 Flexible Footwear and Insole in Heel Pain Unknown status NCT03040557 Phase 1, Phase 2
3 Autologous Stem Cells in Achilles Tendinopathy Unknown status NCT02064062 Phase 2
4 Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation Completed NCT02428296 Phase 2 Sirolimus
5 Efficacy, Safety and Tolerability of AIN457 in Patients With Rheumatoid Arthritis (RA) Taking Methotrexate (MTX) Completed NCT00928512 Phase 2 Secukinmab;Placebo
6 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
7 Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial Terminated NCT01183637 Phase 2
8 Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome Completed NCT02544659 Phase 1 pamidronate disodium
9 Hypophosphatemic Rickets in Norway Unknown status NCT01057186 Sevelamer
10 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Unknown status NCT02934100 Not Applicable
11 Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis Completed NCT01417455
12 Nottingham Osteoarthritis Biomarker Study 2011 Completed NCT01495455
13 Immune Response in the SAPHO Syndrome Completed NCT01688219
14 Clinical Observation Study With the SBG Stem Completed NCT02338661
15 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
16 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698 Not Applicable
17 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932 Not Applicable
18 Characterize Patients With Moderately Active Rheumatoid Arthritis (RA) Completed NCT01557322 methotrexate (MTX)
19 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
20 Effect of Chosen Treatment Methods in Patients With Cervical Spine Osteoarthritis Completed NCT03683602 Not Applicable
21 NGS Strategy Effectiveness in Molecular Diagnosis Completed NCT03557567
22 Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease Recruiting NCT02504879
23 Genetic and Functional Analysis of Craniometaphyseal Dysplasia (CMD) Recruiting NCT01630460
24 Analysis of a Tapered Porous Coated Stem and a Cementless Hemispherical Acetabular Component Recruiting NCT03168750 Not Applicable
25 Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Active, not recruiting NCT03237455 Not Applicable
26 Evaluation of Radiculitis Following Use of Bone Morphogenetic Protein-2 for Interbody Arthrodesis in Spinal Surgery Active, not recruiting NCT00984672
27 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
28 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850

Search NIH Clinical Center for Hyperostosis

Cochrane evidence based reviews: hyperostosis

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Genetic Tests for Hyperostosis

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Genetic tests related to Hyperostosis:

# Genetic test Affiliating Genes
1 Hyperostosis 30
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Anatomical Context for Hyperostosis

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MalaCards organs/tissues related to Hyperostosis:

42
Bone, Spinal Cord, Brain, Heart, Testes, Lung, Bone Marrow
Sources

Publications for Hyperostosis

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Articles related to Hyperostosis:

(show top 50) (show all 1291)
# Title Authors Year
1
Spinal fractures in patients with Diffuse idiopathic skeletal hyperostosis:A nationwide multi-institution survey. ( 30679080 )
2019
2
Ectopic Spinal Calcification Associated with Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Quantitative Micro-CT Analysis. ( 30756413 )
2019
3
Diffuse Idiopathic Skeletal Hyperostosis: A Case with Dysphonia, Dysphagia and Myelopathy. ( 30879018 )
2019
4
Cervical myelopathy revealing a unique case of Retinoid Hyperostosis. ( 30660805 )
2019
5
Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study. ( 30767869 )
2019
6
Hyperostosis frontalis interna as an age-related phenomenon - Differences between males and females and possible use in identification. ( 30798865 )
2019
7
Hypotrichosis with keratosis follicular and hyperostosis: a new phenotype due to GJA1 mutation. ( 30811667 )
2019
8
Monoclonal Gammopathy of Undetermined Significance in a Patient With Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis (SAPHO) Syndrome: Coincidence or Association? ( 30870251 )
2019
9
Thoracic aortic aneurysm is an independent factor associated with diffuse idiopathic skeletal hyperostosis. ( 29701101 )
2018
10
Images in Neuroscience: Calvarial hyperostosis associated with multiple intracranial tumours. ( 29428264 )
2018
11
The Natural Course of Diffuse Idiopathic Skeletal Hyperostosis in the Thoracic Spine of Adult Males. ( 29657149 )
2018
12
Regional differences in diffuse idiopathic skeletal hyperostosis: a retrospective cohort study from Sweden and Japan. ( 29916957 )
2018
13
Simultaneous Bilateral Quadriceps Tendon Rupture in a Patient with Diffuse Idiopathic Skeletal Hyperostosis after Minimal Trauma: Eight-Year Follow-Up. ( 29682378 )
2018
14
Anterior longitudinal ligament in diffuse idiopathic skeletal hyperostosis: Ossified or displaced? ( 29667228 )
2018
15
Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects. ( 29848322 )
2018
16
The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis. ( 29438856 )
2018
17
L5-S1 Charcot spine induced by diffuse idiopathic skeletal hyperostosis in chronic tetraplegia: 2 cases. ( 29920334 )
2018
18
Rich table but short life: Diffuse idiopathic skeletal hyperostosis in Danish astronomer Tycho Brahe (1546-1601) and its possible consequences. ( 29672561 )
2018
19
Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis. ( 29621230 )
2018
20
Esophageal incarceration associated with cervical vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis. ( 29935973 )
2018
21
Diffuse Idiopathic Skeletal Hyperostosis-On the Wrong Side? ( 29481728 )
2018
22
Severe hip joint motion restriction in a patient with diffuse idiopathic skeletal hyperostosis: A case report. ( 29718882 )
2018
23
Degenerative changes of the thoracic spine do exist in patients with diffuse idiopathic skeletal hyperostosis: a detailed thoracic spine CT analysis. ( 29482347 )
2018
24
Urgent Anterior Cervical Osteophytectomy for an Asymptomatic Cervical Hyperostosis to Overcome Failed Intubation. ( 29868301 )
2018
25
Traumatic spondyloptosis at the thoracolumbar junction in a patient with diffuse idiopathic skeletal hyperostosis: A case report. ( 29478625 )
2018
26
Unusual findings on infantile cortical hyperostosis: A case report. ( 29956834 )
2018
27
Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )
2018
28
Meningioma and Bone Hyperostosis: Expression of Bone Stimulating Factors and Review of the Literature. ( 29729471 )
2018
29
Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis. ( 29547116 )
2018
30
Cervical Hyperostosis Leading to Dyspnea, Aspiration and Dysphagia: Strategies to Improve Patient Management. ( 29740589 )
2018
31
Diffuse Idiopathic Skeletal Hyperostosis Extended to the Lumbar Segment is a Risk Factor of Reoperation in Patients Treated Surgically for Lumbar Stenosis. ( 29481381 )
2018
32
Serum Levels of proinflammatory, antiinflammatory cytokines and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) Syndrome. ( 29694253 )
2018
33
Bone mineral density changes over time in diffuse idiopathic skeletal hyperostosis of the thoracic spine. ( 29649655 )
2018
34
Prevalence of Diffuse Idiopathic Skeletal Hyperostosis Diagnosed by Whole Spine Computed Tomography: A Preliminary Study. ( 29564046 )
2018
35
A frontal sinus osteoma accompanied by an intracranial mucocele and local hyperostosis frontalis interna. ( 29452329 )
2018
36
Giant Bilateral Calvarial Hyperostosis Secondary to Small Unilateral Frontal Meningioma. ( 30271067 )
2018
37
Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome - Two Presentations of the Same Disease? ( 30390722 )
2018
38
Abdominal fat distribution in diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis patients compared to controls. ( 30031587 )
2018
39
Diffuse Idiopathic Skeletal Hyperostosis in an HLA-B27-Positive Subject. ( 30048388 )
2018
40
Simultaneous occurrence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis: a systematic review. ( 30060244 )
2018
41
Prevalence and Distribution of Diffuse Idiopathic Skeletal Hyperostosis on Whole-spine Computed Tomography in Patients With Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Study. ( 30113323 )
2018
42
The controlled study of diffuse idiopathic skeletal hyperostosis for the assessment of physical function in elderly populations. ( 30119929 )
2018
43
Serum adiponectin levels in patients with diffuse idiopathic skeletal hyperostosis (DISH). ( 30121711 )
2018
44
Management of Airway Obstruction due to Diffuse Idiopathic Skeletal Hyperostosis in the Cervical Spine: A Case Report and Literature Review. ( 30146564 )
2018
45
Selective mortality in middle-aged American women with Diffuse Idiopathic Skeletal Hyperostosis (DISH). ( 30153267 )
2018
46
Diffuse Idiopathic Skeletal Hyperostosis and Ankylosing Spondylitis. Comment on the article by Latourte et al. ( 30192072 )
2018
47
Response to: "Diffuse Idiopathic Skeletal Hyperostosis and Ankylosing Spondylitis. Comment on the article by Latourte et al" by Olmedo-Garzón and Ruiz-Ollero. ( 30192080 )
2018
48
Aortic pulsation prevents the development of ossification of anterior longitudinal ligament toward the aorta in patients with diffuse idiopathic skeletal hyperostosis (DISH) in Japanese: Results of chest CT-based cross-sectional study. ( 30232028 )
2018
49
Prevalence of diffuse idiopathic skeletal hyperostosis among elderly subjects referred for radiological investigation in tertiary hospital at Oman. ( 30310709 )
2018
50
Spinal fractures in patients with diffuse idiopathic skeletal hyperostosis: Clinical characteristics by fracture level. ( 30415821 )
2018
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Variations for Hyperostosis

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Expression for Hyperostosis

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Search GEO for disease gene expression data for Hyperostosis.
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Pathways for Hyperostosis

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Pathways related to Hyperostosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cardiomyocyte hypertrophy 1
Show member pathways
 11.78 IGF1 LRP5 TGFB1
2
Senescence and Autophagy in Cancer 1
11.57 COL1A1 IGF1 TGFB1
3
Parathyroid hormone synthesis, secretion and action 38
11.48 FGF23 KL LRP5 SOST
4
Endochondral Ossification 1
11.31 ALPL IGF1 TGFB1
5
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.09 COL1A1 IGF1 TNFRSF11B
6
Wnt signaling network 1
10.88 KREMEN1 LRP5
7
Negative regulation of TCF-dependent signaling by WNT ligand antagonists 67
Show member pathways
 10.45 KREMEN1 LRP5 SOST
8
Osteoblast Signaling 1
9.95 COL1A1 FGF23 TNFRSF11B
Sources

GO Terms for Hyperostosis

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Cellular components related to Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALPL COL1A1 FGF23 IGF1 KL SOST
2 extracellular matrix GO:0031012 9.26 ALPL COL1A1 TGFB1 TNFRSF11B
3 extracellular space GO:0005615 9.23 ALPL COL1A1 FGF23 IGF1 KL SOST

Biological processes related to Hyperostosis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.76 FGF23 KL TGFB1
2 regulation of signaling receptor activity GO:0010469 9.72 FGF23 IGF1 KL TGFB1 TNFRSF11B
3 negative regulation of canonical Wnt signaling pathway GO:0090090 9.7 KREMEN1 LRP4 SOST
4 Wnt signaling pathway GO:0016055 9.67 KREMEN1 LRP4 LRP5 SOST
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 IGF1 LRP4 TGFB1
6 positive regulation of transcription, DNA-templated GO:0045893 9.63 COL1A1 FGF23 IGF1 LRP5 SOST TGFB1
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.61 FGF23 GALNT3 KL
8 positive regulation of mitotic nuclear division GO:0045840 9.58 IGF1 LRP5
9 endochondral ossification GO:0001958 9.57 ALPL COL1A1
10 regulation of bone mineralization GO:0030500 9.56 ANKH FGF23
11 phosphate-containing compound metabolic process GO:0006796 9.55 FGF23 TGFB1
12 response to vitamin D GO:0033280 9.54 ALPL TGFB1
13 positive regulation of transcription regulatory region DNA binding GO:2000679 9.51 IGF1 TGFB1
14 response to magnesium ion GO:0032026 9.49 FGF23 TNFRSF11B
15 cell activation GO:0001775 9.48 IGF1 TGFB1
16 cellular response to parathyroid hormone stimulus GO:0071374 9.4 FGF23 SOST
17 skeletal system development GO:0001501 9.35 ALPL ANKH COL1A1 IGF1 TNFRSF11B
18 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.26 FGF23 KL
19 negative regulation of ossification GO:0030279 8.92 KREMEN1 LRP4 SOST TGFB1

Molecular functions related to Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 FGF23 IGF1 TGFB1
2 fibroblast growth factor receptor binding GO:0005104 8.62 FGF23 KL
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Sources for Hyperostosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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