MCID: HYP364
MIFTS: 29

Hyperostosis Frontalis Interna

Categories: Bone diseases, Fetal diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Hyperostosis Frontalis Interna

MalaCards integrated aliases for Hyperostosis Frontalis Interna:

Name: Hyperostosis Frontalis Interna 56 74 58 71
Morgagni-Stewart-Morel Syndrome 56 52 58
Hyperostosis Frontalis Interna, Obesity, Shortness and Cognitive Impairment 52
Msm Syndrome 52

Characteristics:

Orphanet epidemiological data:

58
morgagni-stewart-morel syndrome
Inheritance: Autosomal dominant,X-linked recessive; Age of onset: Adult;

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
hyperostosis frontalis interna:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

OMIM 56 144800
ICD10 via Orphanet 33 M85.2
UMLS via Orphanet 72 C0020494
Orphanet 58 ORPHA77296
MedGen 41 C0020494
UMLS 71 C0020494

Summaries for Hyperostosis Frontalis Interna

NIH Rare Diseases : 52 Morgagni-Stewart-Morel (MSM) syndrome is a disorder characterized by thickening of the frontal bone of the skull (hyperostosis frontalis interna), as well as obesity and excessive hair growth (hypertrichosis). Other signs and symptoms may include seizures , headaches, diabetes insipidus , and sex gland disturbances. The cause of Morgagni-Stewart-Morel syndrome is not fully understood. Some instances of dominant inheritance have been reported, but whether it is autosomal dominant or X-linked dominant is not known. Treatment may include medication for headaches and seizures and surgery to remove the excessive bone of the skull.

MalaCards based summary : Hyperostosis Frontalis Interna, also known as morgagni-stewart-morel syndrome, is related to hyperostosis and headache. Affiliated tissues include bone, brain and eye, and related phenotypes are obesity and diabetes mellitus

Wikipedia : 74 Hyperostosis frontalis interna is a common, benign thickening of the inner side of the frontal bone of... more...

More information from OMIM: 144800

Related Diseases for Hyperostosis Frontalis Interna

Diseases related to Hyperostosis Frontalis Interna via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 hyperostosis 11.4
2 headache 10.6
3 acromegaly 10.5
4 hypertriglyceridemia, familial 10.4
5 vitiligo-associated multiple autoimmune disease susceptibility 6 10.4
6 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4
7 mental depression 10.4
8 hyperuricemia 10.4
9 psychotic disorder 10.4
10 galactorrhoea-hyperprolactinaemia 10.4
11 pseudobulbar affect 10.4
12 depression 10.4
13 chronic pain 10.4
14 osteoporosis 10.4
15 bone mineral density quantitative trait locus 8 10.4
16 bone mineral density quantitative trait locus 15 10.4
17 amenorrhea 10.4
18 mammary paget's disease 10.4
19 subacute delirium 10.4
20 intracranial hypertension 10.4
21 amyotrophic lateral sclerosis 1 10.3
22 breast cancer 10.3
23 migraine with or without aura 1 10.3
24 temporal arteritis 10.3
25 pituitary adenoma 4, acth-secreting 10.3
26 galactorrhea 10.3
27 myxedema 10.3
28 3-methylglutaconic aciduria, type iii 10.3
29 aging 10.3
30 kearns-sayre syndrome 10.3
31 hyperphosphatemia 10.3
32 crest syndrome 10.3
33 polycystic kidney disease 10.3
34 hypogonadotropic hypogonadism 10.3
35 prostatic hypertrophy 10.3
36 hypoparathyroidism 10.3
37 visual epilepsy 10.3
38 gout 10.3
39 epilepsy 10.3
40 hypogonadism 10.3
41 lateral sclerosis 10.3
42 arteriosclerosis 10.3
43 adenocarcinoma 10.3
44 unverricht-lundborg syndrome 10.3
45 syphilis 10.3
46 hyperglycemia 10.3
47 cerebral angioma 10.3
48 diffuse idiopathic skeletal hyperostosis 10.3
49 acth-secreting pituitary adenoma 10.3
50 vasculitis 10.3

Graphical network of the top 20 diseases related to Hyperostosis Frontalis Interna:



Diseases related to Hyperostosis Frontalis Interna

Symptoms & Phenotypes for Hyperostosis Frontalis Interna

Human phenotypes related to Hyperostosis Frontalis Interna:

31 (show all 8)
# Description HPO Frequency HPO Source Accession
1 obesity 31 HP:0001513
2 diabetes mellitus 31 HP:0000819
3 galactorrhea 31 HP:0100829
4 irregular menstruation 31 HP:0000858
5 hypertrichosis 31 HP:0000998
6 increased circulating prolactin concentration 31 HP:0000870
7 elevated alkaline phosphatase 31 HP:0003155
8 hyperostosis frontalis interna 31 HP:0004438

Symptoms via clinical synopsis from OMIM:

56
Growth:
obesity

Skin:
hypertrichosis

Misc:
mainly females

Endocrine:
diabetes mellitus
galactorrhea
hyperprolactinemia
menstrual irregularity

Skull:
hyperostosis frontalis interna

Lab:
hyperphosphatasemia

Clinical features from OMIM:

144800

Drugs & Therapeutics for Hyperostosis Frontalis Interna

Search Clinical Trials , NIH Clinical Center for Hyperostosis Frontalis Interna

Genetic Tests for Hyperostosis Frontalis Interna

Anatomical Context for Hyperostosis Frontalis Interna

MalaCards organs/tissues related to Hyperostosis Frontalis Interna:

40
Bone, Brain, Eye, Cortex, Breast, Ovary, Uterus

Publications for Hyperostosis Frontalis Interna

Articles related to Hyperostosis Frontalis Interna:

(show top 50) (show all 228)
# Title Authors PMID Year
1
Hyperostosis frontalis, galactorrhoea/hyperprolactinaemia, and Morgagni-Stewart-Morel syndrome. 56 61
6131191 1983
2
Hyperostosis frontalis interna and hyperphosphatasemia. 56 61
4721177 1973
3
[Family affected by hyperostosis frontalis interna (Morgagni-Morel syndrome) through 4 successive generations]. 56 61
4659165 1972
4
Hyperostosis frontalis interna requiring craniotomy for intracranial hypertension. 61 52
24384350 2014
5
Hyperostosis frontalis interna. 61 52
16476822 2006
6
Morgagni Stewart Morel syndrome--additional features. 61 52
15805672 2005
7
Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance? 61
32142095 2020
8
Finding of Hyperostosis Frontalis Interna During the Autopsy Procedure: Forensic Issues. 61
31162647 2019
9
Hyperostosis frontalis interna in ancient populations from the Carpathian Basin - A possible relationship between lifestyle and risk of development. 61
30342349 2019
10
Hyperostosis frontalis interna as an age-related phenomenon - Differences between males and females and possible use in identification. 61
30798865 2019
11
Incidental findings on cerebral MRI in twins: the Older Australian Twins Study. 61
28676986 2018
12
Frontal Sinus Osteoma Accompanied by Intracranial Mucocele and Local Hyperostosis Frontalis Interna. 61
29452329 2018
13
Hyperostosis Frontalis Interna in Myotonic Dystrophy. 61
28824073 2017
14
Hyperostosis frontalis interna in female historic skeletal populations: Age, sex hormones and the impact of industrialization. 61
27901271 2017
15
Hyperostosis Frontalis Interna in a Child With Severe Traumatic Brain Injury. 61
28503629 2017
16
3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. 61
27279170 2016
17
Hyperostosis frontalis interna in postmenopausal women-Possible relation to osteoporosis. 61
27093135 2016
18
Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy. 61
27556792 2016
19
Hyperostosis frontalis interna presenting as depression and parkinsonism in an older woman. 61
26551972 2016
20
[Morgagni-Stewart-Morel syndrome. Case report and review of the literature]. 61
27428347 2016
21
What do cranial bones of LB1 tell us about Homo floresiensis? 61
27086053 2016
22
Hyperostosis frontalis interna as a potential source of cerebral oximetry signal interference: A case report. 61
25906264 2015
23
Neuropsychological profile of a male psychiatric patient with a Morgagni-Stewart-Morel syndrome. 61
25382447 2015
24
Dental status and 3D reconstruction of the malocclusion of the famous singer Farinelli (1705-1782). 61
29539492 2014
25
Does hyperostosis frontalis interna have any clinical relevance in stroke patients? 61
24974394 2014
26
Hyperostosis frontalis interna in a Neandertal from Marillac (Charente, France). 61
24491378 2014
27
[Hyperostosis frontalis interna and epilepsy]. 61
24303658 2013
28
Full penetrance of Morgagni-Stewart-Morel syndrome in a 75-year-old woman: case report and review of the literature. 61
23284007 2013
29
Intracranial volume, cranial thickness, and hyperostosis frontalis interna in the elderly. 61
23012133 2012
30
[The phenomenon of hyperostosis frontalis interna--state of the art knowledge]. 61
23650850 2012
31
Frontal cortex dysfunction due to extensive hyperostosis frontalis interna. 61
22665704 2012
32
Benign hyperostotic mass of the frontal bone. 61
22337455 2012
33
[Morgagni Stewart Morel Syndrome]. 61
23241289 2012
34
[Rare diseases. The Morgagni Stewart Morel syndrome]. 61
23241298 2012
35
Hyperostosis frontalis interna (HFI) and castration: the case of the famous singer Farinelli (1705-1782). 61
21740437 2011
36
Etiopathogenesis of hyperostosis frontalis interna: a mystery still. 61
21684729 2011
37
Hyperostosis frontalis interna: criteria for sexing and aging a skeleton. 61
20652712 2011
38
Hyperostosis frontalis interna: what does it tell us about our health? 61
21387460 2011
39
[Diagnostic references in osteo-archeology. The contribution of historical medical data]. 61
21936216 2011
40
Hyperostosis frontalis interna mimicking Mount Fuji sign. 61
21751633 2011
41
Hyperostosis frontalis interna - a marker of social status? Evidence from the Bronze-Age "high society" of Qatna, Syria. 61
21238960 2011
42
Identifying and classifying hyperostosis frontalis interna via computerized tomography. 61
21046669 2010
43
Rate of occurrence, gross appearance, and age relation of hyperostosis frontalis interna in females: a prospective autopsy study. 61
20177366 2010
44
Hyperostosis frontalis interna and androgen suppression. 61
20665812 2010
45
Appearance of hyperostosis frontalis interna in some osteoarcheological series from Hungary. 61
19339004 2009
46
A case of extensive hyperostosis frontalis interna in an 87-year-old female human cadaver. 61
18351650 2008
47
Hyperostosis frontalis interna in a patient with giant cell arteritis. 61
18250961 2008
48
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. 61
18071629 2007
49
Hyperostosis frontalis interna as a novel finding in Unverricht-Lundborg disease. 61
17389316 2007
50
Analysis of human skeletal remains from Nadin iron age burial mound. 61
17243552 2006

Variations for Hyperostosis Frontalis Interna

Expression for Hyperostosis Frontalis Interna

Search GEO for disease gene expression data for Hyperostosis Frontalis Interna.

Pathways for Hyperostosis Frontalis Interna

GO Terms for Hyperostosis Frontalis Interna

Sources for Hyperostosis Frontalis Interna

3 CDC
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50 NDF-RT
53 NINDS
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57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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