MCID: HYP364
MIFTS: 29

Hyperostosis Frontalis Interna

Categories: Bone diseases, Fetal diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Hyperostosis Frontalis Interna

MalaCards integrated aliases for Hyperostosis Frontalis Interna:

Name: Hyperostosis Frontalis Interna 57 74 58 71
Morgagni-Stewart-Morel Syndrome 57 20 58
Hyperostosis Frontalis Interna, Obesity, Shortness and Cognitive Impairment 20
Msm Syndrome 20

Characteristics:

Orphanet epidemiological data:

58
morgagni-stewart-morel syndrome
Inheritance: Autosomal dominant,X-linked recessive; Age of onset: Adult;

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant


HPO:

31
hyperostosis frontalis interna:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

OMIM® 57 144800
ICD10 via Orphanet 33 M85.2
UMLS via Orphanet 72 C0020494
Orphanet 58 ORPHA77296
MedGen 41 C0020494
UMLS 71 C0020494

Summaries for Hyperostosis Frontalis Interna

GARD : 20 Morgagni-Stewart-Morel (MSM) syndrome is a disorder characterized by thickening of the frontal bone of the skull (hyperostosis frontalis interna), as well as obesity and excessive hair growth (hypertrichosis). Other signs and symptoms may include seizures, headaches, diabetes insipidus, and sex gland disturbances. The cause of Morgagni-Stewart-Morel syndrome is not fully understood. Some instances of dominant inheritance have been reported, but whether it is autosomal dominant or X-linked dominant is not known. Treatment may include medication for headaches and seizures and surgery to remove the excessive bone of the skull.

MalaCards based summary : Hyperostosis Frontalis Interna, also known as morgagni-stewart-morel syndrome, is related to hyperostosis and acromegaly. Affiliated tissues include bone, brain and eye, and related phenotypes are diabetes mellitus and obesity

Wikipedia : 74 Hyperostosis frontalis interna is a common, benign thickening of the inner side of the frontal bone of... more...

More information from OMIM: 144800

Related Diseases for Hyperostosis Frontalis Interna

Diseases related to Hyperostosis Frontalis Interna via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 hyperostosis 11.3
2 acromegaly 10.4
3 headache 10.4
4 osteoporosis 10.3
5 bone mineral density quantitative trait locus 8 10.3
6 bone mineral density quantitative trait locus 15 10.3
7 amenorrhea 10.3
8 mammary paget's disease 10.3
9 subacute delirium 10.3
10 intracranial hypertension 10.3
11 type 2 diabetes mellitus 10.3
12 hypertriglyceridemia, familial 10.3
13 vitiligo-associated multiple autoimmune disease susceptibility 6 10.3
14 vitiligo-associated multiple autoimmune disease susceptibility 1 10.3
15 mental depression 10.3
16 hyperuricemia 10.3
17 psychotic disorder 10.3
18 galactorrhoea-hyperprolactinaemia 10.3
19 pseudobulbar affect 10.3
20 depression 10.3
21 chronic pain 10.3
22 amyotrophic lateral sclerosis 1 10.2
23 temporal arteritis 10.2
24 chondrosarcoma 10.2
25 galactorrhea 10.2
26 myxedema 10.2
27 3-methylglutaconic aciduria, type iii 10.2
28 osteogenic sarcoma 10.2
29 aging 10.2
30 kearns-sayre syndrome 10.2
31 hyperphosphatemia 10.2
32 crest syndrome 10.2
33 polycystic kidney disease 10.2
34 parkinsonism 10.2
35 hypogonadotropic hypogonadism 10.2
36 prostatic hypertrophy 10.2
37 hypoparathyroidism 10.2
38 gout 10.2
39 epilepsy 10.2
40 bone cancer 10.2
41 hypogonadism 10.2
42 lateral sclerosis 10.2
43 arteriosclerosis 10.2
44 unverricht-lundborg syndrome 10.2
45 syphilis 10.2
46 hyperglycemia 10.2
47 cerebral angioma 10.2
48 diffuse idiopathic skeletal hyperostosis 10.2
49 vasculitis 10.2
50 hypoglycemia 10.2

Graphical network of the top 20 diseases related to Hyperostosis Frontalis Interna:



Diseases related to Hyperostosis Frontalis Interna

Symptoms & Phenotypes for Hyperostosis Frontalis Interna

Human phenotypes related to Hyperostosis Frontalis Interna:

31 (show all 8)
# Description HPO Frequency HPO Source Accession
1 diabetes mellitus 31 HP:0000819
2 obesity 31 HP:0001513
3 galactorrhea 31 HP:0100829
4 irregular menstruation 31 HP:0000858
5 hypertrichosis 31 HP:0000998
6 elevated alkaline phosphatase 31 HP:0003155
7 increased circulating prolactin concentration 31 HP:0000870
8 hyperostosis frontalis interna 31 HP:0004438

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Endocrine:
diabetes mellitus
galactorrhea
hyperprolactinemia
menstrual irregularity

Skin:
hypertrichosis

Misc:
mainly females

Growth:
obesity

Skull:
hyperostosis frontalis interna

Lab:
hyperphosphatasemia

Clinical features from OMIM®:

144800 (Updated 05-Mar-2021)

Drugs & Therapeutics for Hyperostosis Frontalis Interna

Search Clinical Trials , NIH Clinical Center for Hyperostosis Frontalis Interna

Genetic Tests for Hyperostosis Frontalis Interna

Anatomical Context for Hyperostosis Frontalis Interna

MalaCards organs/tissues related to Hyperostosis Frontalis Interna:

40
Bone, Brain, Eye, Cortex, Breast, Uterus

Publications for Hyperostosis Frontalis Interna

Articles related to Hyperostosis Frontalis Interna:

(show top 50) (show all 237)
# Title Authors PMID Year
1
Hyperostosis frontalis, galactorrhoea/hyperprolactinaemia, and Morgagni-Stewart-Morel syndrome. 61 57
6131191 1983
2
Hyperostosis frontalis interna and hyperphosphatasemia. 57 61
4721177 1973
3
[Family affected by hyperostosis frontalis interna (Morgagni-Morel syndrome) through 4 successive generations]. 57 61
4659165 1972
4
Hyperostosis frontalis interna requiring craniotomy for intracranial hypertension. 61 20
24384350 2014
5
Hyperostosis frontalis interna. 20 61
16476822 2006
6
Morgagni Stewart Morel syndrome--additional features. 20 61
15805672 2005
7
A rare case of hyperostosis frontalis interna in an 86-year-old Japanese female cadaver. 61
33001387 2021
8
"Skull on Fire": Monostotic Paget Disease of the Skull Bone. 61
33156053 2021
9
Comparative Analysis of Femoral Macro- and Micromorphology in Males and Females With and Without Hyperostosis Frontalis Interna: A Cross-Sectional Cadaveric Study. 61
32748007 2020
10
Co-occurrence of malignant neoplasm and Hyperostosis Frontalis Interna in an Iron Age individual from Münsingen-Rain (Switzerland): A multi-diagnostic study. 61
33176226 2020
11
Micro-computed Tomography Study of Frontal Bones in Males and Females with Hyperostosis Frontalis Interna. 61
32712779 2020
12
Hyperostosis frontalis interna diagnosed after a provoked seizure. 61
32611657 2020
13
Hyperostosis frontalis interna and frontal bone thickness among various age groups - differences between males and females. 61
33462799 2020
14
Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance? 61
32142095 2020
15
Finding of Hyperostosis Frontalis Interna During the Autopsy Procedure: Forensic Issues. 61
31162647 2019
16
Hyperostosis frontalis interna in ancient populations from the Carpathian Basin - A possible relationship between lifestyle and risk of development. 61
30342349 2019
17
Hyperostosis frontalis interna as an age-related phenomenon - Differences between males and females and possible use in identification. 61
30798865 2019
18
Incidental findings on cerebral MRI in twins: the Older Australian Twins Study. 61
28676986 2018
19
Frontal Sinus Osteoma Accompanied by Intracranial Mucocele and Local Hyperostosis Frontalis Interna. 61
29452329 2018
20
Hyperostosis Frontalis Interna in Myotonic Dystrophy. 61
28824073 2017
21
Hyperostosis frontalis interna in female historic skeletal populations: Age, sex hormones and the impact of industrialization. 61
27901271 2017
22
Hyperostosis Frontalis Interna in a Child With Severe Traumatic Brain Injury. 61
28503629 2017
23
Hyperostosis frontalis interna in postmenopausal women-Possible relation to osteoporosis. 61
27093135 2016
24
3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. 61
27279170 2016
25
Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy. 61
27556792 2016
26
Hyperostosis frontalis interna presenting as depression and parkinsonism in an older woman. 61
26551972 2016
27
[Morgagni-Stewart-Morel syndrome. Case report and review of the literature]. 61
27428347 2016
28
What do cranial bones of LB1 tell us about Homo floresiensis? 61
27086053 2016
29
Hyperostosis frontalis interna as a potential source of cerebral oximetry signal interference: A case report. 61
25906264 2015
30
Neuropsychological profile of a male psychiatric patient with a Morgagni-Stewart-Morel syndrome. 61
25382447 2015
31
Dental status and 3D reconstruction of the malocclusion of the famous singer Farinelli (1705-1782). 61
29539492 2014
32
Does hyperostosis frontalis interna have any clinical relevance in stroke patients? 61
24974394 2014
33
Hyperostosis frontalis interna in a Neandertal from Marillac (Charente, France). 61
24491378 2014
34
[Hyperostosis frontalis interna and epilepsy]. 61
24303658 2013
35
Full penetrance of Morgagni-Stewart-Morel syndrome in a 75-year-old woman: case report and review of the literature. 61
23284007 2013
36
Intracranial volume, cranial thickness, and hyperostosis frontalis interna in the elderly. 61
23012133 2012
37
[The phenomenon of hyperostosis frontalis interna--state of the art knowledge]. 61
23650850 2012
38
Frontal cortex dysfunction due to extensive hyperostosis frontalis interna. 61
22665704 2012
39
[Rare diseases. The Morgagni Stewart Morel syndrome]. 61
23241298 2012
40
Benign hyperostotic mass of the frontal bone. 61
22337455 2012
41
[Morgagni Stewart Morel Syndrome]. 61
23241289 2012
42
Hyperostosis frontalis interna (HFI) and castration: the case of the famous singer Farinelli (1705-1782). 61
21740437 2011
43
Etiopathogenesis of hyperostosis frontalis interna: a mystery still. 61
21684729 2011
44
Hyperostosis frontalis interna: criteria for sexing and aging a skeleton. 61
20652712 2011
45
Hyperostosis frontalis interna: what does it tell us about our health? 61
21387460 2011
46
[Diagnostic references in osteo-archeology. The contribution of historical medical data]. 61
21936216 2011
47
Hyperostosis frontalis interna mimicking Mount Fuji sign. 61
21751633 2011
48
Hyperostosis frontalis interna - a marker of social status? Evidence from the Bronze-Age "high society" of Qatna, Syria. 61
21238960 2011
49
Identifying and classifying hyperostosis frontalis interna via computerized tomography. 61
21046669 2010
50
Rate of occurrence, gross appearance, and age relation of hyperostosis frontalis interna in females: a prospective autopsy study. 61
20177366 2010

Variations for Hyperostosis Frontalis Interna

Expression for Hyperostosis Frontalis Interna

Search GEO for disease gene expression data for Hyperostosis Frontalis Interna.

Pathways for Hyperostosis Frontalis Interna

GO Terms for Hyperostosis Frontalis Interna

Sources for Hyperostosis Frontalis Interna

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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