Hyperpituitarism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hyperpituitarism

MalaCards integrated aliases for Hyperpituitarism:

Name: Hyperpituitarism ¹¹ ⁴³ ¹⁴ ¹⁶ ⁷¹ ⁷⁵

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:2444

MeSH ⁴³ D006964

SNOMED-CT ⁶⁸ 10649000

EFO ¹⁶ EFO_1000973

UMLS ⁷¹ C0020506

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Summaries for Hyperpituitarism

MalaCards based summary: Hyperpituitarism is related to galactorrhea and graves disease 1. An important gene associated with Hyperpituitarism is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are TGF-Beta Pathway and Prolactin Signaling. Affiliated tissues include pituitary, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: ⁷⁵ Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones;[medical... more...

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Related Diseases for Hyperpituitarism

Diseases related to Hyperpituitarism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)

#	Related Disease	Score	Top Affiliating Genes
1	galactorrhea	30.7	PRL IGF1
2	graves disease 1	30.6	TRH POMC INS
3	pituitary hormone deficiency, combined, 2	29.8	TRH PRL POMC IGF1 GHRH GHR
4	hyperthyroidism	29.8	TRH SST PRL POMC INS IGF1
5	hypopituitarism	29.4	TRH PRL POMC INS IGFBP3 IGF1
6	hypoglycemia	29.3	TRH SST PRL POMC INS IGFBP3
7	acromegaly	28.0	TRH SSTR5 SSTR2 SSTR1 SST PRL
8	bronchial adenomas/carcinoids childhood	10.4	SST POMC
9	retroperitoneal hemangiopericytoma	10.4	INS IGF1
10	optic nerve sheath meningioma	10.4	SSTR2 SST
11	premature ovarian failure 7	10.4	POMC GH1
12	suprasellar meningioma	10.4	TRH POMC
13	carcinoid syndrome	10.4	SST IGF1 GHRH
14	functionless pituitary adenoma	10.4	SST POMC IGF1
15	null pituitary adenoma	10.3	MEN1 AIP
16	chiasmal syndrome	10.3	SST PRL POMC
17	silent pituitary adenoma	10.3	MEN1 AIP
18	isolated growth hormone deficiency	10.3	IGF1 GHRH GH1
19	ectopic cushing syndrome	10.3	SST PRL POMC
20	tuberculum sellae meningioma	10.3	PRL POMC GHRH
21	sella turcica neoplasm	10.3	PRL POMC GHRH
22	cavernous sinus thrombosis	10.3	POMC INS
23	non-functioning pancreatic endocrine tumor	10.3	SST MEN1
24	gastric gastrinoma	10.3	SST MEN1
25	pancreatic somatostatinoma	10.3	SST MEN1
26	scleredema adultorum	10.3	POMC INS
27	abducens palsy	10.3	PRL POMC
28	factitious disorder	10.3	POMC INS
29	postgastrectomy syndrome	10.3	SST INS
30	hirata disease	10.3	POMC INS
31	ulcer of lower limbs	10.3	INS IGF1
32	brain meningioma	10.3	SSTR2 SST
33	lactocele	10.3	TRH PRL GHRH
34	gastrointestinal neuroendocrine benign tumor	10.3	SST MEN1
35	partial third-nerve palsy	10.3	PRL POMC GH1
36	cranial nerve malignant neoplasm	10.3	SSTR2 SST POMC
37	telogen effluvium	10.3	PRL IGF1
38	van maldergem syndrome 1	10.3	PRL POMC GH1
39	acth-independent macronodular adrenal hyperplasia 1	10.3	POMC GNAS
40	nerve compression syndrome	10.3	INS IGF1 GHRH
41	androgenic alopecia	10.3	PRL INS IGF1
42	melancholia	10.3	TRH PRL POMC
43	thyroid hormone resistance, selective pituitary	10.3	TRH SST
44	acth deficiency, isolated	10.3	TRH PRL POMC
45	common bile duct neoplasm	10.3	SST GNAS
46	mixed cerebral palsy	10.3	TRH PRL
47	duodenal gastrinoma	10.3	SST MEN1
48	short bowel syndrome	10.3	SST IGF1 GH1
49	optic nerve neoplasm	10.3	SSTR2 SST
50	persistent fetal circulation syndrome	10.3	POMC INS IGF1

Graphical network of the top 20 diseases related to Hyperpituitarism:

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Symptoms & Phenotypes for Hyperpituitarism

GenomeRNAi Phenotypes related to Hyperpituitarism according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	AIP GH1 GH2 GHR GHRH GNAS
2	no effect	GR00402-S-2	10.18	AIP GH1 GH2 GHR GNAS GPR101

MGI Mouse Phenotypes related to Hyperpituitarism:

⁴⁵ (show all 14)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.41	AIP GH1 GH2 GHR GHRH GNAS
2	nervous system	MP:0003631	10.4	GH1 GH2 GHR GHRH GNAS IGF1
3	growth/size/body region	MP:0005378	10.34	AIP GH1 GH2 GHR GHRH GNAS
4	endocrine/exocrine gland	MP:0005379	10.28	AIP GH1 GH2 GHR GHRH GNAS
5	liver/biliary system	MP:0005370	10.27	AIP GH1 GH2 GHR GHRH GNAS
6	behavior/neurological	MP:0005386	10.25	GH1 GH2 GHR GHRH GNAS GPR101
7	adipose tissue	MP:0005375	10.22	GH1 GH2 GHR GHRH GNAS IGF1
8	renal/urinary system	MP:0005367	10.21	GH1 GH2 GHR GNAS IGF1 INS
9	cardiovascular system	MP:0005385	10.21	AIP GH1 GH2 GHR GHRH GNAS
10	neoplasm	MP:0002006	10.08	AIP GNAS IGF1 MEN1 POMC PRKAR1A
11	immune system	MP:0005387	10.07	GH1 GH2 GHR GHRH GNAS IGF1
12	reproductive system	MP:0005389	9.85	GH1 GH2 GHR GHRH IGF1 INS
13	skeleton	MP:0005390	9.65	GHR GHRH GNAS IGF1 IGFBP3 INS
14	integument	MP:0010771	9.32	AIP GHR GNAS IGF1 IGFBP3 INS

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Drugs & Therapeutics for Hyperpituitarism

Search Clinical Trials, NIH Clinical Center for Hyperpituitarism

Cochrane evidence based reviews: hyperpituitarism

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Genetic Tests for Hyperpituitarism

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Anatomical Context for Hyperpituitarism

Organs/tissues related to Hyperpituitarism:

MalaCards : Pituitary

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Publications for Hyperpituitarism

Articles related to Hyperpituitarism:

(show all 34)

#	Title	Authors	PMID	Year
1	Pituicytoma Associated with Suspected Cushing's Disease: Two Case Reports and a Literature Review. ⁶²	Xiao T...Pan H	36013043	2022
2	Pituitary surgery's epidemiology using a national inpatient database in Japan. ⁶²	Hattori Y...Morita A	32125502	2020
3	Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells. ⁶²	Musha S...Tomura H	31956173	2020
4	Imaging of pediatric pituitary endocrinopathies. ⁶²	Chaudhary V...Bano S	23087850	2012
5	Clinical differentiation of primary from secondary hyperhidrosis. ⁶²	Walling HW	21334095	2011
6	[History of pituitary surgery]. ⁶²	Hardy J	20096901	2010
7	[Osteoporosis during development--selected problems]. ⁶²	Chlebna-Sokol D	9333882	1997
8	Graphic analysis for the study of metabolic states. ⁶²	Summers RL...Hall JE	8712258	1996
9	Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. ⁶²	Murakami S...Miura S	8555708	1995
10	Age-related changes in hormones in impotent men. Jefferson Sexual Function Center. ⁶²	Carroll JL...Bagley DH	2114689	1990
11	[Medical topics: treatment of hyperpituitarism; stomach cancer after gastric resection]. ⁶²	Shibusawa K	3649468	1986
12	Investigation of hypothalamic-pituitary disease. ⁶²	Lamberton RP...Jackson IM	6323063	1983
13	The renin-angiotensin-aldosterone system in primary and secondary hypertension. ⁶²	del Greco F...Santhanam S	6119955	1981
14	Transsphenoidal neurosurgery of intracranial neoplasm. ⁶²	Hardy J...Vezina JL	945663	1976
15	[Common occurrence of estrinism and adenomyosis due to gonadotropic partial hyperpituitarism during late climacteric]. ⁶²	Foukas M	5368197	1969
16	[Anterior hyperpituitarism due to post-traumatic carotido-cavernous aneurysm]. ⁶²	Linquette M...Montois R	5682071	1968
17	Congenital hyperpituitarism of hypothalamic origin: a new diencephalic syndrome with endocrine manifestations. ⁶²	SEIP M	14444640	1959
18	Psychological findings in a case of von Recklinghausen's disease and hyperpituitarism. ⁶²	JORDAN TE	13367234	1956
19	[Three cases of obesity in Pende's anterior hyperpituitarism]. ⁶²	GAMBARO GC...PAVERO A	13293028	1955
20	[Hyperpituitarism and hemorrhagic aneurysm of the anterior cerebras artery]. ⁶²	BOULET P...VLAHOVITCH A	13288406	1955
21	[Hyperluteal amenorrheas in young diabetics; unusual manifestation of combined hyperpituitarism]. ⁶²	BOULET P...AUBANEL M	13288405	1955
22	Further evidence that hyperthyroidism (Graves' disease) is not hyperpituitarism: effects of triiodothyronine and sodium iodide. ⁶²	WERNER SC...HAMILTON H	14367487	1955
23	[Postdiabetic hypoglycemia; hyperpituitarism at onset and panhypopituitarism in later stages]. ⁶²	BOULET P...MIROUZE J	13235710	1954
24	Graves' disease: hyperthyroidism or hyperpituitarism. ⁶²	WERNER SC...NEMETH M	13022743	1952
25	[Persistent galactorrhea; a case of functional galactotropic hyperpituitarism]. ⁶²	SANTISTEBAN P...ALVAREZ COCA M	14945077	1952
26	[Basedow's disease from hyperpituitarism; importance of the biologic determination of the thyrotropic hormone for diagnosis; remarkable effectiveness of pituitary inhibiting therapeutic agents]. ⁶²	RIVIERE J	14853591	1951
27	[Contribution to the study of persistent galactorrhea; comments on a case of galactrophic functional hyperpituitarism]. ⁶²	SANTISTEBAN ABAD P	15409407	1949
28	Morgagni endocraniosis highlighted by a head injury with reactive serous meningitis syndrome and acromegaloid hyperpituitarism. ⁶²	LEVI M	18879519	1948
29	Creatine-creatinine metabolism in adult and juvenile hyperpituitarism. ⁶²	SCHRIRE I	18877070	1948
30	[Disorders of peripheral circulation in hyperpituitarism during puberty]. ⁶²	SCHWANK	18107498	1947
31	Hyperpituitarism and Hypopituitarism. ⁶²	Davidoff LM	19312151	1940
32	Thyrotoxicosis with Unilateral Exophthalmos, Hyperpituitarism, and Infantile Hemiplegia. ⁶²	Worster-Drought C	19990197	1935
33	Gigantism and Acromegaly: Hyperpituitarism. ⁶²	Weinberg SJ	33944128	1931
34	Case of Hyperpituitarism. ⁶²		19984234	1925

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Genes for Hyperpituitarism

Genes related to Hyperpituitarism (0 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGF1	Insulin Like Growth Factor 1	Protein Coding	9.94	DISEASES inferred ¹⁴
2	SST	Somatostatin	Protein Coding	9.73	DISEASES inferred ¹⁴
3	GHRH	Growth Hormone Releasing Hormone	Protein Coding	8.71	DISEASES inferred ¹⁴
4	PRL	Prolactin	Protein Coding	8.64	DISEASES inferred ¹⁴
5	POMC	Proopiomelanocortin	Protein Coding	8.32	DISEASES inferred ¹⁴
6	SSTR5	Somatostatin Receptor 5	Protein Coding	8.08	DISEASES inferred ¹⁴
7	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	8.07	DISEASES inferred ¹⁴
8	GH1	Growth Hormone 1	Protein Coding	7.95	DISEASES inferred ¹⁴
9	SSTR2	Somatostatin Receptor 2	Protein Coding	7.9	DISEASES inferred ¹⁴
10	TRH	Thyrotropin Releasing Hormone	Protein Coding	7.87	DISEASES inferred ¹⁴
11	INS	Insulin	Protein Coding	7.79	DISEASES inferred ¹⁴
12	GHR	Growth Hormone Receptor	Protein Coding	7.64	DISEASES inferred ¹⁴
13	SSTR1	Somatostatin Receptor 1	Protein Coding	7.51	DISEASES inferred ¹⁴
14	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	7.46	DISEASES inferred ¹⁴
15	MEN1	Menin 1	Protein Coding	7.42	DISEASES inferred ¹⁴
16	GPR101	G Protein-Coupled Receptor 101	Protein Coding	7.42	DISEASES inferred ¹⁴
17	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	7.29	DISEASES inferred ¹⁴
18	GH2	Growth Hormone 2	Protein Coding	6.94	DISEASES inferred ¹⁴
19	GNAS	GNAS Complex Locus	Protein Coding	6.81	DISEASES inferred ¹⁴
20	SSTR3	Somatostatin Receptor 3	Protein Coding	6.8	DISEASES inferred ¹⁴
21	SSTR4	Somatostatin Receptor 4	Protein Coding	6.74	DISEASES inferred ¹⁴
22	SNED1	Sushi, Nidogen And EGF Like Domains 1	Protein Coding	6.66	DISEASES inferred ¹⁴
23	GCG	Glucagon	Protein Coding	6.65	DISEASES inferred ¹⁴
24	CRH	Corticotropin Releasing Hormone	Protein Coding	6.62	DISEASES inferred ¹⁴
25	IGF2	Insulin Like Growth Factor 2	Protein Coding	6.61	DISEASES inferred ¹⁴
26	GHRHR	Growth Hormone Releasing Hormone Receptor	Protein Coding	6.43	DISEASES inferred ¹⁴

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Variations for Hyperpituitarism

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Expression for Hyperpituitarism

Search GEO for disease gene expression data for Hyperpituitarism.

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Pathways for Hyperpituitarism

Pathways related to Hyperpituitarism according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.4	PRL INS IGF1 GNAS GHRH GHR
2	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.33	PRL PRKAR1A IGF1 GNAS GHR GH2
3	GPCR downstream signalling ⁶⁶ Show member pathways G alpha (i) signalling events ⁶⁶ G alpha (q) signalling events ⁶⁶ Signaling by GPCR ⁶⁶	13.29	TRH SSTR5 SSTR3 SSTR2 SSTR1 SST
4	Class A/1 (Rhodopsin-like receptors) ⁶⁶ Show member pathways GPCR ligand binding ⁶⁶ GPCRs, class A rhodopsin-like ⁷⁴ Peptide GPCRs ⁷⁴ Peptide ligand-binding receptors ⁶⁶	13.04	GHRH GNAS POMC SST SSTR1 SSTR2
5	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	12.88	GH1 GH2 GHRH GNAS IGF1 INS
6	Signal Transduction ⁶⁶	12.85	TRH SSTR5 SSTR3 SSTR2 SSTR1 SST
7	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.76	PRL INS IGF1 GHR GH2 GH1
8	Translation Insulin regulation of translation ²² Show member pathways Butyrate-induced histone acetylation ⁷⁴ Cell adhesion PLAU signaling ²² Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 ⁷⁴ Regulation of lipid metabolism Insulin signaling-generic cascades ²² Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation inhibitors in chronically activated PDGFRA cells ⁷⁴	12.56	PRKAR1A INS IGFBP3 IGF1 GHR GH1
9	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.55	PRKAR1A IGF1 GHRH GH2 GH1
10	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.43	PRKAR1A POMC GNAS GHRH GH2 GH1
11	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁷⁴ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶ thyroid hormone biosynthesis ⁶¹	12.06	POMC INS IGF1 GH1
12	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	12.02	PRKAR1A POMC GNAS GHRH
13	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12	SSTR2 SSTR1 SST PRKAR1A
14	Senescence and autophagy in cancer ⁷⁴	11.78	INS IGFBP3 IGF1
15	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.73	INS IGFBP3 IGF1
16	Prader-Willi and Angelman syndrome ⁷⁴	11.5	GHRH INS POMC
17	G-protein signaling_RhoA regulation pathway ²²	11.32	PRKAR1A IGF1 GNAS GHRH GH2 GH1
18	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.88	PRL POMC INS
19	G-protein signaling_Rap2B regulation pathway ²²	10.87	IGF1 GNAS GHRH GH2 GH1
20	Growth hormone receptor signaling ⁶⁶ Show member pathways Prolactin receptor signaling ⁶⁶	10.85	PRL GHR GH2 GH1

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GO Terms for Hyperpituitarism

Cellular components related to Hyperpituitarism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.37	SST PRL POMC INS IGFBP3 IGF1
2	extracellular region	GO:0005576	10.22	GH1 GH2 GHR GHRH GNAS IGF1
3	insulin-like growth factor ternary complex	GO:0042567	9.62	IGFBP3 IGF1
4	insulin-like growth factor binding protein complex	GO:0016942	9.56	IGFBP3 IGF1
5	growth hormone receptor complex	GO:0070195	9.26	GHR GH1
6	endosome lumen	GO:0031904	9.23	PRL INS GH2 GH1

Biological processes related to Hyperpituitarism according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.28	IGFBP3 MEN1 SST SSTR1 SSTR2 SSTR3
2	G protein-coupled receptor signaling pathway	GO:0007186	10.27	SSTR5 SSTR3 SSTR2 SSTR1 SST INS
3	cell-cell signaling	GO:0007267	10.15	TRH SSTR3 SST POMC INS GHRH
4	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	10.08	IGF1 GHR GH2 GH1
5	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	10.06	SSTR5 SSTR3 SSTR2 SSTR1
6	signal transduction	GO:0007165	10.06	TRH SSTR5 SSTR3 SSTR2 SSTR1 PRL
7	cerebellum development	GO:0021549	10.05	SSTR3 SSTR2 SSTR1
8	cellular response to estradiol stimulus	GO:0071392	10.04	SSTR3 SSTR2 SSTR1
9	response to starvation	GO:0042594	10.03	SSTR3 SSTR2 SSTR1
10	neuropeptide signaling pathway	GO:0007218	10.02	SSTR5 SSTR3 SSTR2 SSTR1 POMC
11	positive regulation of multicellular organism growth	GO:0040018	10.01	GHRH GHR GH1
12	regulation of multicellular organism growth	GO:0040014	10	PRL IGF1 GHR
13	cellular response to glucocorticoid stimulus	GO:0071385	9.99	SSTR2 SSTR3 SSTR5
14	growth hormone receptor signaling pathway	GO:0060396	9.88	GHR GH2 GH1
15	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	9.86	GH1 GH2 GHR PRL
16	hormone-mediated apoptotic signaling pathway	GO:0008628	9.85	SSTR3 SST
17	positive regulation of insulin-like growth factor receptor signaling pathway	GO:0043568	9.56	IGFBP3 IGF1 GHRH GH1
18	somatostatin signaling pathway	GO:0038170	9.23	SSTR5 SSTR3 SSTR2 SSTR1

Molecular functions related to Hyperpituitarism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptide binding	GO:0042277	9.92	SSTR5 SSTR3 SSTR2 SSTR1
2	neuropeptide binding	GO:0042923	9.76	SSTR1 SSTR2 SSTR3 SSTR5
3	insulin-like growth factor receptor binding	GO:0005159	9.73	INS IGF1 GNAS
4	prolactin receptor binding	GO:0005148	9.67	PRL GH1
5	somatostatin receptor activity	GO:0004994	9.56	SSTR5 SSTR3 SSTR2 SSTR1
6	hormone activity	GO:0005179	9.53	TRH SST PRL POMC INS IGF1

Sources

Sources for Hyperpituitarism

¹ BitterDB

² CDC

³ Cell Signaling Technology

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⁸ Cosmic

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

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³⁵ IUPHAR

³⁶ LifeMap

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: HYP070 MIFTS: 32	Hyperpituitarism Categories: Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
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