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MCID: HYP070
MIFTS: 38

Hyperpituitarism

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hyperpituitarism

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MalaCards integrated aliases for Hyperpituitarism:

Name: Hyperpituitarism 12 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2444
MeSH 43 D006964
SNOMED-CT 67 10649000
UMLS 71 C0020506
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Summaries for Hyperpituitarism

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MalaCards based summary : Hyperpituitarism is related to galactorrhea and graves disease 1. An important gene associated with Hyperpituitarism is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Hydrocortisone acetate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and breast, and related phenotypes are homeostasis/metabolism and behavior/neurological

Wikipedia : 74 Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; it typically... more...

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Related Diseases for Hyperpituitarism

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Diseases related to Hyperpituitarism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 galactorrhea 31.2 PRL IGF1
2 graves disease 1 30.6 TRH POMC INS
3 hypoglycemia 29.4 SST PRL POMC INS IGFBP3 IGF1
4 hyperthyroidism 29.3 TRH SST PRL POMC INS IGF1
5 hypopituitarism 29.1 TRH PRL POMC INS IGFBP3 IGF1
6 pituitary hormone deficiency, combined, 2 29.1 TRH PRL POMC INS IGFBP3 IGF1
7 body mass index quantitative trait locus 11 28.4 TRH PRL POMC INS IGFBP3 IGF1
8 bronchial adenomas/carcinoids childhood 10.6 SST POMC
9 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 10.5 GHRH GH1
10 generalized resistance to thyroid hormone 10.5 TRH PRL
11 lactocele 10.5 TRH PRL
12 suprasellar meningioma 10.5 TRH POMC
13 acth-dependent cushing syndrome 10.5 PRL POMC
14 tuberculum sellae meningioma 10.5 PRL POMC
15 sella turcica neoplasm 10.5 PRL POMC
16 lymphocytic hypophysitis 10.5 POMC GH1
17 slipped capital femoral epiphysis 10.5 IGFBP3 IGF1
18 transient refractive change 10.5 SST INS
19 prolactin producing pituitary tumor 10.5 PRL POMC
20 congenital hypopituitarism 10.5 PRL IGF1 GHRH
21 type c thymoma 10.5 SSTR2 SST
22 null pituitary adenoma 10.4 MEN1 AIP
23 silent pituitary adenoma 10.4 MEN1 AIP
24 gangliocytoma 10.4 PRL POMC GHRH
25 central precocious puberty 10.4 IGF1 GH1
26 gastrointestinal neuroendocrine benign tumor 10.4 SST MEN1
27 hypothalamic obesity 10.4 INS IGF1 GHRH
28 acth deficiency, isolated 10.4 TRH PRL POMC
29 central nervous system benign neoplasm 10.4 PRL POMC IGF1
30 non-functioning pancreatic endocrine tumor 10.4 SST MEN1
31 isolated growth hormone deficiency, type ii 10.4 IGF1 GHRH GH1
32 familial isolated pituitary adenoma 10.4 MEN1 AIP
33 protein-deficiency anemia 10.4 INS GH1
34 diabetes insipidus, neurohypophyseal 10.4 TRH PRL POMC
35 hypothyroidism, congenital, nongoitrous, 4 10.4 PRL POMC GH1
36 nerve compression syndrome 10.4 INS IGF1 GHRH
37 hypoadrenalism 10.4 POMC GH1
38 androgenic alopecia 10.4 PRL INS IGF1
39 benign essential hypertension 10.4 PRL POMC INS
40 persistent fetal circulation syndrome 10.4 POMC INS IGF1
41 mammographic density 10.4 PRL IGFBP3 IGF1
42 short bowel syndrome 10.4 SST IGF1 GH1
43 adult syndrome 10.4 POMC INS IGF1
44 steroid inherited metabolic disorder 10.4 PRL POMC INS
45 non-functioning pituitary adenoma 10.4 SST GHR GH1
46 isolated growth hormone deficiency type iii 10.4 GHRH GH1
47 pancreatic cholera 10.4 SST MEN1 GHRH
48 gastric neuroendocrine neoplasm 10.4 SST MEN1
49 sexual disorder 10.4 PRL POMC INS
50 basophil adenoma 10.3 PRKAR1A POMC

Graphical network of the top 20 diseases related to Hyperpituitarism:



Diseases related to Hyperpituitarism
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Symptoms & Phenotypes for Hyperpituitarism

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MGI Mouse Phenotypes related to Hyperpituitarism:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 AIP GHR GHRH GNAS GPR101 IGF1
2 behavior/neurological MP:0005386 10.32 GHR GHRH GNAS IGFBP3 INS POMC
3 endocrine/exocrine gland MP:0005379 10.29 AIP GHR GHRH GNAS IGF1 IGFBP3
4 cardiovascular system MP:0005385 10.27 AIP GHR GNAS GPR101 IGF1 INS
5 growth/size/body region MP:0005378 10.27 AIP GHR GHRH GNAS IGF1 IGFBP3
6 immune system MP:0005387 10.14 GHR GHRH GNAS IGF1 INS MEN1
7 adipose tissue MP:0005375 10.13 GHR GHRH GNAS IGF1 IGFBP3 INS
8 integument MP:0010771 10.07 AIP GHR GNAS IGF1 IGFBP3 INS
9 liver/biliary system MP:0005370 10.02 AIP GHR GHRH GNAS IGFBP3 INS
10 nervous system MP:0003631 9.93 GHR GHRH GNAS IGF1 INS MEN1
11 neoplasm MP:0002006 9.8 AIP GNAS IGF1 MEN1 POMC PRKAR1A
12 no phenotypic analysis MP:0003012 9.5 GNAS INS POMC SST SSTR3 SSTR4
13 skeleton MP:0005390 9.28 GHR GHRH GNAS IGF1 IGFBP3 INS
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Drugs & Therapeutics for Hyperpituitarism

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Drugs for Hyperpituitarism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
2
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
3
Pasireotide Approved Phase 3 396091-73-9 9941444
4 Hydrocortisone hemisuccinate Phase 3
5 Hormone Antagonists Phase 3
6 Hydrocortisone 17-butyrate 21-propionate Phase 3
7 Melanocyte-Stimulating Hormones Phase 3
8 beta-endorphin Phase 3
9 Hormones Phase 3
10 Adrenocorticotropic Hormone Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of Pasireotide LAR in Patients With Cushing's Disease Completed NCT01374906 Phase 3 pasireotide LAR;SOM230 LAR 30 mg;SOM230 LAR 10 mg

Search NIH Clinical Center for Hyperpituitarism

Cochrane evidence based reviews: hyperpituitarism

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Genetic Tests for Hyperpituitarism

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Anatomical Context for Hyperpituitarism

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MalaCards organs/tissues related to Hyperpituitarism:

40
Pituitary, Thyroid, Breast, Pineal, Cortex, Kidney, Liver
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Publications for Hyperpituitarism

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Articles related to Hyperpituitarism:

(show all 30)
# Title Authors PMID Year
1
Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells. 61
31956173 2020
2
Imaging of pediatric pituitary endocrinopathies. 61
23087850 2012
3
Clinical differentiation of primary from secondary hyperhidrosis. 61
21334095 2011
4
[History of pituitary surgery]. 61
20096901 2010
5
[Osteoporosis during development--selected problems]. 61
9333882 1997
6
Graphic analysis for the study of metabolic states. 61
8712258 1996
7
Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. 61
8555708 1995
8
Age-related changes in hormones in impotent men. Jefferson Sexual Function Center. 61
2114689 1990
9
[Medical topics: treatment of hyperpituitarism; stomach cancer after gastric resection]. 61
3649468 1986
10
Investigation of hypothalamic-pituitary disease. 61
6323063 1983
11
The renin-angiotensin-aldosterone system in primary and secondary hypertension. 61
6119955 1981
12
Transsphenoidal neurosurgery of intracranial neoplasm. 61
945663 1976
13
[Common occurrence of estrinism and adenomyosis due to gonadotropic partial hyperpituitarism during late climacteric]. 61
5368197 1969
14
[Anterior hyperpituitarism due to post-traumatic carotido-cavernous aneurysm]. 61
5682071 1968
15
Congenital hyperpituitarism of hypothalamic origin: a new diencephalic syndrome with endocrine manifestations. 61
14444640 1959
16
Psychological findings in a case of von Recklinghausen's disease and hyperpituitarism. 61
13367234 1956
17
[Three cases of obesity in Pende's anterior hyperpituitarism]. 61
13293028 1955
18
[Hyperluteal amenorrheas in young diabetics; unusual manifestation of combined hyperpituitarism]. 61
13288405 1955
19
[Hyperpituitarism and hemorrhagic aneurysm of the anterior cerebras artery]. 61
13288406 1955
20
Further evidence that hyperthyroidism (Graves' disease) is not hyperpituitarism: effects of triiodothyronine and sodium iodide. 61
14367487 1955
21
[Postdiabetic hypoglycemia; hyperpituitarism at onset and panhypopituitarism in later stages]. 61
13235710 1954
22
Graves' disease: hyperthyroidism or hyperpituitarism. 61
13022743 1952
23
[Persistent galactorrhea; a case of functional galactotropic hyperpituitarism]. 61
14945077 1952
24
[Basedow's disease from hyperpituitarism; importance of the biologic determination of the thyrotropic hormone for diagnosis; remarkable effectiveness of pituitary inhibiting therapeutic agents]. 61
14853591 1951
25
[Contribution to the study of persistent galactorrhea; comments on a case of galactrophic functional hyperpituitarism]. 61
15409407 1949
26
Creatine-creatinine metabolism in adult and juvenile hyperpituitarism. 61
18877070 1948
27
[Disorders of peripheral circulation in hyperpituitarism during puberty]. 61
18107498 1947
28
Hyperpituitarism and Hypopituitarism. 61
19312151 1940
29
Thyrotoxicosis with Unilateral Exophthalmos, Hyperpituitarism, and Infantile Hemiplegia. 61
19990197 1935
30
Case of Hyperpituitarism. 61
19984234 1925
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Variations for Hyperpituitarism

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Expression for Hyperpituitarism

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Search GEO for disease gene expression data for Hyperpituitarism.
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Pathways for Hyperpituitarism

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Pathways related to Hyperpituitarism according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.86 TRH SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2
Peptide ligand-binding receptors 65
Show member pathways
 13.05 TRH SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3
p70S6K Signaling 63
Show member pathways
 12.9 PRKAR1A INS IGF1 GNAS GHRH GH1
4
PI3K-Akt signaling pathway 36
Show member pathways
 12.81 PRL INS IGF1 GNAS GHR GH1
5
Regulation of lipid metabolism Insulin signaling-generic cascades 22
Show member pathways
 12.65 PRKAR1A INS IGFBP3 IGF1 GHR GH1
6
Peptide hormone metabolism 65
Show member pathways
 12.07 POMC INS IGF1 GH1
7
Relaxin signaling pathway 36
Show member pathways
 12 SSTR5 SSTR3 SSTR2 SSTR1 SST POMC
8
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.97 SSTR2 SSTR1 SST PRKAR1A
9
cAMP signaling pathway 36
11.97 SSTR5 SSTR2 SSTR1 SST POMC GNAS
10
Endochondral Ossification 1
11.51 IGF1 GHR GH1
11
G-protein signaling_RhoA regulation pathway 22
11.46 PRKAR1A IGF1 GNAS GHRH GH1
12
Ovarian steroidogenesis 36
11.34 INS IGF1 GNAS
13
Growth hormone receptor signaling 65
Show member pathways
 11.22 PRL GHR GH1
14
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.73 PRL POMC INS
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GO Terms for Hyperpituitarism

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Cellular components related to Hyperpituitarism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 SST PRL POMC INS IGFBP3 IGF1
2 integral component of plasma membrane GO:0005887 9.95 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 GPR101
3 extracellular region GO:0005576 9.7 TRH SST PRL POMC INS IGFBP3
4 insulin-like growth factor ternary complex GO:0042567 9.37 IGFBP3 IGF1
5 insulin-like growth factor binding protein complex GO:0016942 9.26 IGFBP3 IGF1
6 growth hormone receptor complex GO:0070195 9.16 GHR GH1
7 endosome lumen GO:0031904 8.8 PRL INS GH1

Biological processes related to Hyperpituitarism according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.07 TRH SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2 negative regulation of cell proliferation GO:0008285 9.97 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
3 cell-cell signaling GO:0007267 9.93 TRH SSTR3 SST POMC INS GHRH
4 cellular protein metabolic process GO:0044267 9.91 PRL MEN1 INS IGFBP3 IGF1
5 forebrain development GO:0030900 9.8 SSTR4 SSTR3 SSTR2 SSTR1
6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.8 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.79 IGF1 GHR GH1
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.79 INS IGF1 GH1
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IGF1 GHR GH1
10 cerebellum development GO:0021549 9.76 SSTR3 SSTR2 SSTR1
11 response to starvation GO:0042594 9.74 SSTR3 SSTR2 SSTR1
12 cellular response to estradiol stimulus GO:0071392 9.73 SSTR3 SSTR2 SSTR1
13 cellular response to glucocorticoid stimulus GO:0071385 9.73 SSTR5 SSTR4 SSTR3 SSTR2
14 G protein-coupled receptor signaling pathway GO:0007186 9.73 TRH SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
15 positive regulation of multicellular organism growth GO:0040018 9.72 GHRH GHR GH1
16 positive regulation of JAK-STAT cascade GO:0046427 9.71 PRL GHR GH1
17 regulation of multicellular organism growth GO:0040014 9.7 PRL IGF1 GHR
18 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.65 PRL GHR GH1
19 neuropeptide signaling pathway GO:0007218 9.63 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 POMC
20 insulin-like growth factor receptor signaling pathway GO:0048009 9.62 IGF1 GHR
21 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.62 IGFBP3 IGF1 GHRH GH1
22 growth hormone receptor signaling pathway GO:0060396 9.61 GHR GH1
23 negative regulation of feeding behavior GO:2000252 9.59 TRH INS
24 hormone-mediated apoptotic signaling pathway GO:0008628 9.58 SSTR3 SST
25 somatostatin signaling pathway GO:0038170 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Molecular functions related to Hyperpituitarism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide binding GO:0042277 9.65 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2 neuropeptide binding GO:0042923 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 insulin-like growth factor receptor binding GO:0005159 9.5 INS IGF1 GNAS
4 hormone activity GO:0005179 9.5 TRH SST PRL POMC INS IGF1
5 prolactin receptor binding GO:0005148 9.37 PRL GH1
6 somatostatin receptor activity GO:0004994 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
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Sources for Hyperpituitarism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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