MCID: HYP070
MIFTS: 32

Hyperpituitarism

Categories: Endocrine diseases
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Aliases & Classifications for Hyperpituitarism

MalaCards integrated aliases for Hyperpituitarism:

Name: Hyperpituitarism 11 43 14 16 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:2444
MeSH 43 D006964
SNOMED-CT 68 10649000
UMLS 71 C0020506

Summaries for Hyperpituitarism

MalaCards based summary: Hyperpituitarism is related to galactorrhea and graves disease 1. An important gene associated with Hyperpituitarism is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are TGF-Beta Pathway and Prolactin Signaling. Affiliated tissues include pituitary, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: 75 Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones;[medical... more...

Related Diseases for Hyperpituitarism

Diseases related to Hyperpituitarism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 galactorrhea 30.7 PRL IGF1
2 graves disease 1 30.6 TRH POMC INS
3 pituitary hormone deficiency, combined, 2 29.8 TRH PRL POMC IGF1 GHRH GHR
4 hyperthyroidism 29.8 TRH SST PRL POMC INS IGF1
5 hypopituitarism 29.4 TRH PRL POMC INS IGFBP3 IGF1
6 hypoglycemia 29.3 TRH SST PRL POMC INS IGFBP3
7 acromegaly 28.0 TRH SSTR5 SSTR2 SSTR1 SST PRL
8 bronchial adenomas/carcinoids childhood 10.4 SST POMC
9 retroperitoneal hemangiopericytoma 10.4 INS IGF1
10 optic nerve sheath meningioma 10.4 SSTR2 SST
11 premature ovarian failure 7 10.4 POMC GH1
12 suprasellar meningioma 10.4 TRH POMC
13 carcinoid syndrome 10.4 SST IGF1 GHRH
14 functionless pituitary adenoma 10.4 SST POMC IGF1
15 null pituitary adenoma 10.3 MEN1 AIP
16 chiasmal syndrome 10.3 SST PRL POMC
17 silent pituitary adenoma 10.3 MEN1 AIP
18 isolated growth hormone deficiency 10.3 IGF1 GHRH GH1
19 ectopic cushing syndrome 10.3 SST PRL POMC
20 tuberculum sellae meningioma 10.3 PRL POMC GHRH
21 sella turcica neoplasm 10.3 PRL POMC GHRH
22 cavernous sinus thrombosis 10.3 POMC INS
23 non-functioning pancreatic endocrine tumor 10.3 SST MEN1
24 gastric gastrinoma 10.3 SST MEN1
25 pancreatic somatostatinoma 10.3 SST MEN1
26 scleredema adultorum 10.3 POMC INS
27 abducens palsy 10.3 PRL POMC
28 factitious disorder 10.3 POMC INS
29 postgastrectomy syndrome 10.3 SST INS
30 hirata disease 10.3 POMC INS
31 ulcer of lower limbs 10.3 INS IGF1
32 brain meningioma 10.3 SSTR2 SST
33 lactocele 10.3 TRH PRL GHRH
34 gastrointestinal neuroendocrine benign tumor 10.3 SST MEN1
35 partial third-nerve palsy 10.3 PRL POMC GH1
36 cranial nerve malignant neoplasm 10.3 SSTR2 SST POMC
37 telogen effluvium 10.3 PRL IGF1
38 van maldergem syndrome 1 10.3 PRL POMC GH1
39 acth-independent macronodular adrenal hyperplasia 1 10.3 POMC GNAS
40 nerve compression syndrome 10.3 INS IGF1 GHRH
41 androgenic alopecia 10.3 PRL INS IGF1
42 melancholia 10.3 TRH PRL POMC
43 thyroid hormone resistance, selective pituitary 10.3 TRH SST
44 acth deficiency, isolated 10.3 TRH PRL POMC
45 common bile duct neoplasm 10.3 SST GNAS
46 mixed cerebral palsy 10.3 TRH PRL
47 duodenal gastrinoma 10.3 SST MEN1
48 short bowel syndrome 10.3 SST IGF1 GH1
49 optic nerve neoplasm 10.3 SSTR2 SST
50 persistent fetal circulation syndrome 10.3 POMC INS IGF1

Graphical network of the top 20 diseases related to Hyperpituitarism:



Diseases related to Hyperpituitarism

Symptoms & Phenotypes for Hyperpituitarism

GenomeRNAi Phenotypes related to Hyperpituitarism according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 AIP GH1 GH2 GHR GHRH GNAS
2 no effect GR00402-S-2 10.18 AIP GH1 GH2 GHR GNAS GPR101

MGI Mouse Phenotypes related to Hyperpituitarism:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 AIP GH1 GH2 GHR GHRH GNAS
2 nervous system MP:0003631 10.4 GH1 GH2 GHR GHRH GNAS IGF1
3 growth/size/body region MP:0005378 10.34 AIP GH1 GH2 GHR GHRH GNAS
4 endocrine/exocrine gland MP:0005379 10.28 AIP GH1 GH2 GHR GHRH GNAS
5 liver/biliary system MP:0005370 10.27 AIP GH1 GH2 GHR GHRH GNAS
6 behavior/neurological MP:0005386 10.25 GH1 GH2 GHR GHRH GNAS GPR101
7 adipose tissue MP:0005375 10.22 GH1 GH2 GHR GHRH GNAS IGF1
8 renal/urinary system MP:0005367 10.21 GH1 GH2 GHR GNAS IGF1 INS
9 cardiovascular system MP:0005385 10.21 AIP GH1 GH2 GHR GHRH GNAS
10 neoplasm MP:0002006 10.08 AIP GNAS IGF1 MEN1 POMC PRKAR1A
11 immune system MP:0005387 10.07 GH1 GH2 GHR GHRH GNAS IGF1
12 reproductive system MP:0005389 9.85 GH1 GH2 GHR GHRH IGF1 INS
13 skeleton MP:0005390 9.65 GHR GHRH GNAS IGF1 IGFBP3 INS
14 integument MP:0010771 9.32 AIP GHR GNAS IGF1 IGFBP3 INS

Drugs & Therapeutics for Hyperpituitarism

Search Clinical Trials, NIH Clinical Center for Hyperpituitarism

Cochrane evidence based reviews: hyperpituitarism

Genetic Tests for Hyperpituitarism

Anatomical Context for Hyperpituitarism

Organs/tissues related to Hyperpituitarism:

MalaCards : Pituitary

Publications for Hyperpituitarism

Articles related to Hyperpituitarism:

(show all 34)
# Title Authors PMID Year
1
Pituicytoma Associated with Suspected Cushing's Disease: Two Case Reports and a Literature Review. 62
36013043 2022
2
Pituitary surgery's epidemiology using a national inpatient database in Japan. 62
32125502 2020
3
Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells. 62
31956173 2020
4
Imaging of pediatric pituitary endocrinopathies. 62
23087850 2012
5
Clinical differentiation of primary from secondary hyperhidrosis. 62
21334095 2011
6
[History of pituitary surgery]. 62
20096901 2010
7
[Osteoporosis during development--selected problems]. 62
9333882 1997
8
Graphic analysis for the study of metabolic states. 62
8712258 1996
9
Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. 62
8555708 1995
10
Age-related changes in hormones in impotent men. Jefferson Sexual Function Center. 62
2114689 1990
11
[Medical topics: treatment of hyperpituitarism; stomach cancer after gastric resection]. 62
3649468 1986
12
Investigation of hypothalamic-pituitary disease. 62
6323063 1983
13
The renin-angiotensin-aldosterone system in primary and secondary hypertension. 62
6119955 1981
14
Transsphenoidal neurosurgery of intracranial neoplasm. 62
945663 1976
15
[Common occurrence of estrinism and adenomyosis due to gonadotropic partial hyperpituitarism during late climacteric]. 62
5368197 1969
16
[Anterior hyperpituitarism due to post-traumatic carotido-cavernous aneurysm]. 62
5682071 1968
17
Congenital hyperpituitarism of hypothalamic origin: a new diencephalic syndrome with endocrine manifestations. 62
14444640 1959
18
Psychological findings in a case of von Recklinghausen's disease and hyperpituitarism. 62
13367234 1956
19
[Three cases of obesity in Pende's anterior hyperpituitarism]. 62
13293028 1955
20
[Hyperpituitarism and hemorrhagic aneurysm of the anterior cerebras artery]. 62
13288406 1955
21
[Hyperluteal amenorrheas in young diabetics; unusual manifestation of combined hyperpituitarism]. 62
13288405 1955
22
Further evidence that hyperthyroidism (Graves' disease) is not hyperpituitarism: effects of triiodothyronine and sodium iodide. 62
14367487 1955
23
[Postdiabetic hypoglycemia; hyperpituitarism at onset and panhypopituitarism in later stages]. 62
13235710 1954
24
Graves' disease: hyperthyroidism or hyperpituitarism. 62
13022743 1952
25
[Persistent galactorrhea; a case of functional galactotropic hyperpituitarism]. 62
14945077 1952
26
[Basedow's disease from hyperpituitarism; importance of the biologic determination of the thyrotropic hormone for diagnosis; remarkable effectiveness of pituitary inhibiting therapeutic agents]. 62
14853591 1951
27
[Contribution to the study of persistent galactorrhea; comments on a case of galactrophic functional hyperpituitarism]. 62
15409407 1949
28
Morgagni endocraniosis highlighted by a head injury with reactive serous meningitis syndrome and acromegaloid hyperpituitarism. 62
18879519 1948
29
Creatine-creatinine metabolism in adult and juvenile hyperpituitarism. 62
18877070 1948
30
[Disorders of peripheral circulation in hyperpituitarism during puberty]. 62
18107498 1947
31
Hyperpituitarism and Hypopituitarism. 62
19312151 1940
32
Thyrotoxicosis with Unilateral Exophthalmos, Hyperpituitarism, and Infantile Hemiplegia. 62
19990197 1935
33
Gigantism and Acromegaly: Hyperpituitarism. 62
33944128 1931
34
Case of Hyperpituitarism. 62
19984234 1925

Variations for Hyperpituitarism

Expression for Hyperpituitarism

Search GEO for disease gene expression data for Hyperpituitarism.

Pathways for Hyperpituitarism

Pathways related to Hyperpituitarism according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 PRL INS IGF1 GNAS GHRH GHR
2
Show member pathways
13.33 PRL PRKAR1A IGF1 GNAS GHR GH2
3
Show member pathways
13.29 TRH SSTR5 SSTR3 SSTR2 SSTR1 SST
4
Show member pathways
13.04 GHRH GNAS POMC SST SSTR1 SSTR2
5
Show member pathways
12.88 GH1 GH2 GHRH GNAS IGF1 INS
6 12.85 TRH SSTR5 SSTR3 SSTR2 SSTR1 SST
7
Show member pathways
12.76 PRL INS IGF1 GHR GH2 GH1
8
Show member pathways
12.56 PRKAR1A INS IGFBP3 IGF1 GHR GH1
9
Show member pathways
12.55 PRKAR1A IGF1 GHRH GH2 GH1
10
Show member pathways
12.43 PRKAR1A POMC GNAS GHRH GH2 GH1
11
Show member pathways
12.06 POMC INS IGF1 GH1
12
Show member pathways
12.02 PRKAR1A POMC GNAS GHRH
13 12 SSTR2 SSTR1 SST PRKAR1A
14 11.78 INS IGFBP3 IGF1
15 11.73 INS IGFBP3 IGF1
16 11.5 GHRH INS POMC
17 11.32 PRKAR1A IGF1 GNAS GHRH GH2 GH1
18 10.88 PRL POMC INS
19 10.87 IGF1 GNAS GHRH GH2 GH1
20
Show member pathways
10.85 PRL GHR GH2 GH1

GO Terms for Hyperpituitarism

Cellular components related to Hyperpituitarism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.37 SST PRL POMC INS IGFBP3 IGF1
2 extracellular region GO:0005576 10.22 GH1 GH2 GHR GHRH GNAS IGF1
3 insulin-like growth factor ternary complex GO:0042567 9.62 IGFBP3 IGF1
4 insulin-like growth factor binding protein complex GO:0016942 9.56 IGFBP3 IGF1
5 growth hormone receptor complex GO:0070195 9.26 GHR GH1
6 endosome lumen GO:0031904 9.23 PRL INS GH2 GH1

Biological processes related to Hyperpituitarism according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.28 IGFBP3 MEN1 SST SSTR1 SSTR2 SSTR3
2 G protein-coupled receptor signaling pathway GO:0007186 10.27 SSTR5 SSTR3 SSTR2 SSTR1 SST INS
3 cell-cell signaling GO:0007267 10.15 TRH SSTR3 SST POMC INS GHRH
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.08 IGF1 GHR GH2 GH1
5 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 10.06 SSTR5 SSTR3 SSTR2 SSTR1
6 signal transduction GO:0007165 10.06 TRH SSTR5 SSTR3 SSTR2 SSTR1 PRL
7 cerebellum development GO:0021549 10.05 SSTR3 SSTR2 SSTR1
8 cellular response to estradiol stimulus GO:0071392 10.04 SSTR3 SSTR2 SSTR1
9 response to starvation GO:0042594 10.03 SSTR3 SSTR2 SSTR1
10 neuropeptide signaling pathway GO:0007218 10.02 SSTR5 SSTR3 SSTR2 SSTR1 POMC
11 positive regulation of multicellular organism growth GO:0040018 10.01 GHRH GHR GH1
12 regulation of multicellular organism growth GO:0040014 10 PRL IGF1 GHR
13 cellular response to glucocorticoid stimulus GO:0071385 9.99 SSTR2 SSTR3 SSTR5
14 growth hormone receptor signaling pathway GO:0060396 9.88 GHR GH2 GH1
15 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.86 GH1 GH2 GHR PRL
16 hormone-mediated apoptotic signaling pathway GO:0008628 9.85 SSTR3 SST
17 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.56 IGFBP3 IGF1 GHRH GH1
18 somatostatin signaling pathway GO:0038170 9.23 SSTR5 SSTR3 SSTR2 SSTR1

Molecular functions related to Hyperpituitarism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide binding GO:0042277 9.92 SSTR5 SSTR3 SSTR2 SSTR1
2 neuropeptide binding GO:0042923 9.76 SSTR1 SSTR2 SSTR3 SSTR5
3 insulin-like growth factor receptor binding GO:0005159 9.73 INS IGF1 GNAS
4 prolactin receptor binding GO:0005148 9.67 PRL GH1
5 somatostatin receptor activity GO:0004994 9.56 SSTR5 SSTR3 SSTR2 SSTR1
6 hormone activity GO:0005179 9.53 TRH SST PRL POMC INS IGF1

Sources for Hyperpituitarism

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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