MCID: HYP729
MIFTS: 30

Hypersensitivity Reaction Disease

Categories: Immune diseases, Cancer diseases

Aliases & Classifications for Hypersensitivity Reaction Disease

MalaCards integrated aliases for Hypersensitivity Reaction Disease:

Name: Hypersensitivity Reaction Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060056

Summaries for Hypersensitivity Reaction Disease

Disease Ontology : 12 An immune system disease that has material basis in abnormal immune responses.

MalaCards based summary : Hypersensitivity Reaction Disease is related to selective igg deficiency disease and c1q nephropathy. An important gene associated with Hypersensitivity Reaction Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Hypersensitivity Reaction Disease

Diseases in the Hypersensitivity Reaction Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 selective igg deficiency disease 11.4 CD40LG CD79A
2 c1q nephropathy 11.4 CD40LG CD79A
3 gluten allergy 11.3 CD79A TGM2
4 transient neonatal thrombocytopenia 11.3 CD79A TRIM21
5 meningovascular neurosyphilis 11.3 CD40LG CD79A
6 alpha chain disease 11.3 CD40LG CD79A
7 brill-zinsser disease 11.3 CD40LG CD79A
8 exudative glomerulonephritis 11.3 CD40LG CD79A
9 cork-handlers' disease 11.3 CD40LG CD79A
10 ocular toxoplasmosis 11.3 CD40LG CD79A TLR9
11 endocrine exophthalmos 11.3 CD40LG TG
12 salpingo-oophoritis 11.3 CD40LG CD79A
13 hyperglobulinemic purpura 11.3 CD40LG CD79A TRIM21
14 punctate inner choroidopathy 11.3 IL10 TNF
15 early yaws 11.3 CD40LG CD79A
16 ventilation pneumonitis 11.3 CD40LG CD79A
17 chronic interstitial cystitis 11.3 CD40LG CD79A
18 axillary adenitis 11.3 CD40LG CD79A
19 cryofibrinogenemia 11.3 CD40LG CD79A
20 congenital hypogammaglobulinemia 11.3 CD40LG CD79A IL4
21 parasitic ichthyosporea infectious disease 11.3 CD40LG CD79A IL4
22 central nervous system vasculitis 11.3 CD40LG TLR9 TNF
23 rhinosporidiosis 11.3 CD40LG CD79A IL4
24 wheat allergy 11.3 CD79A TGM2 TOR1A
25 lymphoepithelioma-like thymic carcinoma 11.3 FOXP3 TG
26 salivary gland disease 11.3 CD40LG CD79A TRIM21
27 osteosclerotic myeloma 11.3 CD40LG CD79A TNF
28 immunodeficiency with hyper-igm, type 1 11.3 CD40LG CD79A IL4
29 sporotrichosis 11.3 CD40LG CD79A IL10
30 hypersensitivity vasculitis 11.3 CD40LG CD79A MEFV
31 jejunoileitis 11.3 CD40LG CD79A TNF
32 meningoencephalitis 11.3 CD40LG CD79A TLR9
33 acute salpingitis 11.3 CD40LG CD79A TNF
34 monoclonal gammopathy of uncertain significance 11.3 CD40LG CD79A TNF
35 cardiovascular syphilis 11.3 CD40LG DDX41
36 pneumocystosis 11.3 CD40LG CD79A TNF
37 hypersensitivity reaction type iii disease 11.3 CD40LG CD79A MEFV
38 pustulosis palmaris et plantaris 11.3 CD40LG CD79A TNF
39 trichostrongyloidiasis 11.3 CD40LG CD79A
40 congenital syphilis 11.3 CD40LG CD79A DDX41
41 henoch-schoenlein purpura 11.3 CD40LG CD79A MEFV
42 subacute bacterial endocarditis 11.3 CD40LG CD79A
43 ross river fever 11.2 CD40LG IL10
44 mature b-cell neoplasm 11.2 CD40LG CD79A TLR9
45 microscopic colitis 11.2 CD79A IL4 TNF
46 heterophyiasis 11.2 CD40LG CD79A
47 stomach disease 11.2 CD79A TLR9 TRPV1
48 mucocutaneous leishmaniasis 11.2 IL10 TLR9 TNF
49 conjunctival disease 11.2 CD40LG CD79A IL4
50 immunoglobulin g deficiency 11.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Disease:



Diseases related to Hypersensitivity Reaction Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Disease

MGI Mouse Phenotypes related to Hypersensitivity Reaction Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.35 FOXP3 MEFV PRTN3 IL10 CD40LG IL4
2 homeostasis/metabolism MP:0005376 10.31 FOXP3 MEFV APOH IL10 CD40LG IL4
3 hematopoietic system MP:0005397 10.28 FOXP3 MEFV PRTN3 IL10 CD40LG IL4
4 immune system MP:0005387 10.21 FOXP3 MEFV IL10 CD40LG IL4 CD79A
5 endocrine/exocrine gland MP:0005379 10.16 IL4 FOXP3 IL10 CD40LG TGM2 TNF
6 mortality/aging MP:0010768 10.03 DDX41 FOXP3 MEFV APOH IL10 CD40LG
7 integument MP:0010771 9.92 IL4 MEFV FOXP3 IL10 CD40LG TRIM21
8 liver/biliary system MP:0005370 9.8 CD79A IL4 MEFV FOXP3 IL10 TRPV1
9 no phenotypic analysis MP:0003012 9.56 CD79A IL4 FOXP3 IL10 TGM2 TRPV1
10 renal/urinary system MP:0005367 9.28 FOXP3 CD40LG IL4 CD79A TGM2 TRIM21

Drugs & Therapeutics for Hypersensitivity Reaction Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Disease

Genetic Tests for Hypersensitivity Reaction Disease

Anatomical Context for Hypersensitivity Reaction Disease

Publications for Hypersensitivity Reaction Disease

Variations for Hypersensitivity Reaction Disease

Expression for Hypersensitivity Reaction Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Disease.

Pathways for Hypersensitivity Reaction Disease

Pathways related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 CD40LG CD79A DDX41 IL10 IL4 MEFV
2
Show member pathways
13.21 CD40LG IL10 IL4 PRTN3 TNF TNFRSF25
3
Show member pathways
12.54 CD40LG FOXP3 IL10 IL4 TG TNF
4
Show member pathways
12.3 FOXP3 IL10 IL4 TNF
5
Show member pathways
12.28 CD40LG IL10 IL4 TNF
6
Show member pathways
12.07 CD40LG IL10 IL4 TNF
7 11.74 CD40LG CD79A FOXP3 IL10 IL4 TLR9
8 11.73 CD79A IL10 IL4 TNF
9 11.63 IL10 IL4 TNF
10 11.58 IL10 TLR9 TNF
11
Show member pathways
11.56 CD40LG TNF TNFRSF25
12 11.49 CD40LG IL10 IL4
13
Show member pathways
11.34 CD40LG FOXP3 IL4 TNF
14 11.32 IL10 IL4 TNF
15 11.27 FOXP3 IL10 IL4
16 11.12 IL10 TLR9 TNF
17 10.97 IL10 IL4 TNF
18 10.95 CD40LG IL10 TLR9 TNF
19 10.26 TG TSHR

GO Terms for Hypersensitivity Reaction Disease

Cellular components related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 APOH CD40LG IL10 IL4 PRTN3 TG
2 extracellular region GO:0005576 9.32 APOH CD40LG COL17A1 IL10 IL4 PRTN3

Biological processes related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.93 CD40LG IL10 IL4 TNF TNFRSF25
2 regulation of signaling receptor activity GO:0010469 9.92 CD40LG IL10 IL4 TG TNF
3 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.74 FOXP3 TLR9 TRIM21
4 inflammatory response GO:0006954 9.7 CD40LG IL10 MEFV TLR9 TNF TNFRSF25
5 response to molecule of bacterial origin GO:0002237 9.58 IL10 TLR9
6 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
7 negative regulation of interleukin-12 production GO:0032695 9.55 IL10 MEFV
8 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.49 IL10 IL4
10 negative regulation of cytokine secretion involved in immune response GO:0002740 9.48 IL10 TNF
11 type 2 immune response GO:0042092 9.46 IL10 IL4
12 negative regulation of interleukin-8 production GO:0032717 9.43 IL10 TLR9
13 B cell proliferation GO:0042100 9.43 CD40LG CD79A IL10
14 regulation of immunoglobulin secretion GO:0051023 9.4 CD40LG TNF
15 regulation of isotype switching GO:0045191 9.37 IL10 IL4
16 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
17 negative regulation of interleukin-6 production GO:0032715 9.26 FOXP3 IL10 TLR9 TNF
18 B cell differentiation GO:0030183 9.02 CD40LG CD79A IL10 IL4 TSHR

Molecular functions related to Hypersensitivity Reaction Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 APOH CD40LG CD79A COL17A1 DDX41 FOXP3
2 cytokine activity GO:0005125 9.26 CD40LG IL10 IL4 TNF

Sources for Hypersensitivity Reaction Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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