Hypersensitivity Reaction Type Iii Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease ¹¹ ¹⁴

Immune Complex Diseases ⁵³ ⁴³ ⁷¹

Type Iii Hypersensitivity Reaction Disease ¹⁶

Immune Complex Disease ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:1557

MeSH ⁴³ D007105

EFO ¹⁶ EFO_1001222

UMLS ⁷¹ C0020951

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Summaries for Hypersensitivity Reaction Type Iii Disease

Disease Ontology: ¹¹ A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury.

MalaCards based summary: Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to arthus reaction and membranous nephropathy. An important gene associated with Hypersensitivity Reaction Type Iii Disease is C5AR1 (Complement C5a Receptor 1), and among its related pathways/superpathways are Innate Immune System and Complement cascade. The drugs Vaccines and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and neutrophil, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

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Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 907)

#	Related Disease	Score	Top Affiliating Genes
1	arthus reaction	32.4	TNF C5AR1 ALB
2	membranous nephropathy	30.6	CFHR2 CD79A ALB
3	lupus erythematosus	30.5	CCR6 C4B C4A C3
4	purpura	30.3	TNF IL6 CRP CD79A C3
5	cryoglobulinemia	30.3	TNF IL6 CD79A
6	hypersensitivity vasculitis	30.2	TNF SERPINA3 PRTN3 MPO MEST MEFV
7	thrombocytopenia due to platelet alloimmunization	30.2	ICOSLG CD4 CCR6
8	palindromic rheumatism	30.2	PRTN3 MEFV CRP
9	lipoid nephrosis	30.1	SERPINA3 CD79A ALB
10	libman-sacks endocarditis	30.1	PRTN3 CRP CFHR2 C3
11	immune-complex glomerulonephritis	30.1	PRTN3 ICOSLG CFP CFHR2 CD4 C3
12	complement deficiency	30.1	CFP CFHR2 C5AR1 C4B C4A C3
13	pasteurellosis	30.1	SERPINA3 MPO CFHR2 ALB
14	neutrophilia, hereditary	30.0	MPO IL6 CRP
15	liver cirrhosis	30.0	TNF SERPINA3 IL6 ALB
16	thyroiditis	30.0	TNF IL6 CRP
17	cholera	30.0	TNF SERPINA3 IL6 CD79A
18	acute kidney failure	30.0	PRTN3 IL6 ALB
19	lepromatous leprosy	30.0	TNF CD4 CCR6
20	thrombocytopenic purpura, autoimmune	30.0	ICOSLG CD4 CCR6
21	typhoid fever	30.0	TNF IL6 CRP CCR6 ALB
22	viral infectious disease	30.0	TNF SERPINA3 IL6 ICOSLG CD4 CCR6
23	arthropathy	29.9	TNF IL6 CRP CCR6
24	proliferative glomerulonephritis	29.9	PRTN3 MPO ICOSLG CFHR2 CD79A CCR6
25	endocarditis	29.9	TNF IL6 CRP ALB
26	synovitis	29.9	TNF PRTN3 IL6 CRP
27	mesangial proliferative glomerulonephritis	29.9	IL6 CFHR2 CD79A C3 ALB
28	urticaria	29.9	TNF IL6 CRP CD4
29	spondylitis	29.9	TNF IL6 CRP CCR6
30	viral hepatitis	29.9	MPO IL6 CRP ALB
31	extrinsic allergic alveolitis	29.9	TNF CD4 CCR6
32	hepatitis a	29.9	TNF CD4 ALB
33	eclampsia	29.9	TNF IL6 ALB
34	uremia	29.8	TNF IL6 CRP ALB
35	monoclonal gammopathy of uncertain significance	29.8	IL6 ICOSLG CFHR2 CCR6 ALB
36	pfeiffer syndrome	29.8	TNF CRP CD4 CCR6
37	vasculitis	29.8	TNF SERPINA3 PRTN3 MPO MEFV IL6
38	myocarditis	29.7	TNF IL6 CD4 ALB
39	psoriatic arthritis	29.7	TNF IL6 ICOSLG CRP CCR6
40	chronic granulomatous disease	29.7	TNF MPO CFP CD4
41	otitis media	29.7	TNF MPO IL6 CRP CD79A C3
42	common variable immunodeficiency	29.7	TNF MPO IL6 ICOSLG CD79A
43	migraine with or without aura 1	29.6	TNF SERPINA3 IL6 CRP ALB
44	arthritis	29.6	TNF MEFV IL6 CRP CCR6 ALB
45	allergic disease	29.6	TNF SERPINA3 IL6 ICOSLG CD4 CCR6
46	glomerulonephritis	29.6	TNF PRTN3 MPO IL6 FCAR CRP
47	bell's palsy	29.6	TNF IL6 CRP CD4 ALB
48	neutropenia	29.6	TNF MPO IL6 CRP C5AR1 ALB
49	polyarteritis nodosa	29.6	TNF PRTN3 MPO MEFV IL6 CRP
50	portal hypertension	29.6	TNF CCR6 ALB

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:

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Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.17	ALB C3 C4A C5AR1 CCR6 CD79A

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.16	ALB C3 C4A C4B C5AR1 CCR6
2	liver/biliary system	MP:0005370	9.92	ALB C3 C4A C4B CD79A IL6
3	cardiovascular system	MP:0005385	9.9	ALB C3 C4A C4B CCR6 CFP
4	immune system	MP:0005387	9.89	ALB C3 C4A C4B C5AR1 CCR6
5	hematopoietic system	MP:0005397	9.47	C3 C4A C4B C5AR1 CCR6 CD4

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Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Drugs for Hypersensitivity Reaction Type Iii Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Vaccines		Phase 2
2	Immunosuppressive Agents		Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies	Completed	NCT03277703	Phase 2

Search NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

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Genetic Tests for Hypersensitivity Reaction Type Iii Disease

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Anatomical Context for Hypersensitivity Reaction Type Iii Disease

Organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

MalaCards : Kidney, Lung, Neutrophil, Smooth Muscle, Bone Marrow, T Cells, Liver

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Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show top 50) (show all 786)

#	Title	Authors	PMID	Year
1	Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. ⁵³ ⁶²	Fung M...Mollnes TE	12869020	2003
2	Endothelin levels in Henoch-Schonlein purpura. ⁵³ ⁶²	Muslu A...Sakarcan A	12432435	2002
3	Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. ⁵³ ⁶²	Heller T...Kohl J	10395696	1999
4	Pathogenesis of idiopathic IgA nephropathy. ⁵³ ⁶²	Williams DG	8518104	1993
5	Triple-threat quantitative multiplexed plasma proteomics analysis on immune complex disease MRL-lpr mice. ⁶²	Gaun A...McAllister FE	35964289	2022
6	[Cryoglobulinemic vasculitis]. ⁶²	Specker C...Schlaak J	35258723	2022
7	A Case of Focal Segmental Glomerulosclerosis With Immune Complexes: Is HIV, Hepatitis B, or Crack the Culprit? ⁶²	Balozian P...Ravakhah K	34557371	2021
8	Illuminating the in vitro effects of Epstein-Barr virus and vitamin D on immune response in multiple sclerosis patients. ⁶²	Teymoori-Rad M...Marashi SM	33666884	2021
9	BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics. ⁶²	Hall AP...Mukaratirwa S	33455525	2021
10	Profiling Biomarkers in HIV Glomerular Disease - Potential for the Non-Invasive Diagnosis of HIVAN? ⁶²	Naicker S...Duarte R	34916827	2021
11	Type 3 hypersensitivity in COVID-19 vasculitis. ⁶²	Roncati L...Maiorana A	32479986	2020
12	Inflammatory markers in systemic lupus erythematosus. ⁶²	Aringer M	31812331	2020
13	Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease. ⁶²	Kelleher C...Kocinsky H	32553251	2020
14	Contemporary issues and new challenges in chronic kidney disease amongst people living with HIV. ⁶²	Heron JE...Gracey DM	32178687	2020
15	Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates. ⁶²	Laffan SB...Bouma G	32325480	2020
16	HIV/AIDS and chronic kidney disease. ⁶²	Naicker S	31397267	2020
17	[Dermatomyositis combined with IgA vasculitis: A case report]. ⁶²	Xu J...Li SG	31848525	2019
18	[Cutaneous alterations in vasculitides : Part 2: Special aspects of diseases of large, medium and small vessels]. ⁶²	Sunderkotter C...Michl C	31300830	2019
19	Patterns of renal disease: A 30-year renal biopsy study at Chris Hani Baragwanath Academic Hospital, Soweto, Johannesburg, South Africa. ⁶²	Vermeulen A...Naicker S	31266574	2019
20	Immunogenicity and Immune Complex Disease in Preclinical Safety Studies. ⁶²	Vahle JL	30157708	2018
21	Drug-induced Glomerulonephritis: The Spectre of Biotherapeutic and Antisense Oligonucleotide Immune Activation in the Kidney. ⁶²	Frazier KS...Obert LA	30089413	2018
22	Renal involvement in antiphospholipid syndrome. ⁶²	de Azevedo FVA...Rodrigues CEM	29730854	2018
23	Amdoparvovirus Infection in Red Pandas ( Ailurus fulgens). ⁶²	Alex CE...Pesavento PA	29433401	2018
24	Acute Kidney Injury after Pembrolizumab-Induced Adrenalitis and Adrenal Insufficiency. ⁶²	Hanna RM...Rastogi A	30197906	2018
25	Epstein-Barr virus and rheumatoid arthritis. ⁶²	Balandraud N...Roudier J	28499895	2018
26	Nephrotic syndrome due to lupus-like glomerulonephritis in an HIV-positive patient. ⁶²	Wiegersma JS...Diepstra A	29219816	2017
27	APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy. ⁶²	Kopp JB...Winkler CA	29110758	2017
28	Viral-Associated GN: Hepatitis B and Other Viral Infections. ⁶²	Kupin WL	27797900	2017
29	Kidney disease in patients with obesity: It is not always obesity-related glomerulopathy alone. ⁶²	Salvatore SP...Seshan SV	28442280	2017
30	Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. ⁶²	Guo QY...Sun GD	28810602	2017
31	Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia. ⁶²	Al-Hussain T...Akhtar M	28540889	2017
32	[THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE]. ⁶²	Grushka NG	29975827	2017
33	[IgA nephropathy]. ⁶²	Pillebout E...Verine J	27323655	2016
34	Fraternal twins with job's syndrome and immune complex nephritis. ⁶²	Ahmed S...Workeneh B	28509165	2016
35	Bullous Pemphigoid With a Dual Pattern of Glomerular Immune Complex Disease. ⁶²	Hoorn EJ...Schreurs MW	26616334	2016
36	Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. ⁶²	Al-Rabadi L...Ghai S	26613031	2015
37	Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. ⁶²	Couvrat-Desvergnes G...Soulillou JP	26551683	2015
38	Successful and Safe Long-Term Standard Antiviral Therapy in a Patient with "Explosive" Immune Response in Course of HCV-Related Liver Cirrhosis. ⁶²	Conca P...Tarantino G	26101866	2015
39	Vaccination of cattle with the N terminus of LppQ of Mycoplasma mycoides subsp. mycoides results in type III immune complex disease upon experimental infection. ⁶²	Mulongo M...McKeever D	25733516	2015
40	HIV and chronic kidney disease. ⁶²	Naicker S...Kopp JB	25725239	2015
41	[Genotoxic stress and the pathways of thymus cell death and lymph nodes of mice in conditions of immunocomplex pathology]. ⁶²	Grushka NG...Yanchiy RI	26040032	2015
42	Validation of an automated ELISA system for detection of antibodies to Aleutian mink disease virus using blood samples collected in filter paper strips. ⁶²	Knuuttila A...Vapalahti O	25103400	2014
43	[Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?]. ⁶²	Zhu HW...Wen YJ	25272602	2014
44	Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis). ⁶²	Heyen JR...Han B	24616262	2014
45	Membranous glomerulonephritis with crescents. ⁶²	Barrett CM...Houghton DC	24217802	2014
46	Necrotizing arteritis in a human immunodeficiency virus-infected patient with lupus-like glomerulonephritis. ⁶²	Silva GE...Dantas M	24427374	2014
47	Transferrin-immune complex disease: a potentially overlooked gammopathy mediated by IgM and IgG. ⁶²	Forni GL...Ragione FD	23913829	2013
48	Immune complex disease with a lupus-like pattern of deposition in an antinuclear antibody-negative patient. ⁶²	Pirkle JL...Fogo AB	23548558	2013
49	Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. ⁶²	Radic M...Marion TN	23595413	2013
50	The clinical and histological response of HIV-associated kidney disease to antiretroviral therapy in South Africans. ⁶²	Fabian J...Venter WD	23444185	2013

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Genes for Hypersensitivity Reaction Type Iii Disease

Genes related to Hypersensitivity Reaction Type Iii Disease (0 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	C5AR1	Complement C5a Receptor 1	Protein Coding	11.98	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12869020 10395696
2	CD79A	CD79a Molecule	Protein Coding	9.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12432435 8518104
3	CFHR2	Complement Factor H Related 2	Protein Coding	8.59	DISEASES inferred ¹⁴ ¹⁴
4	C3	Complement C3	Protein Coding	7.1	DISEASES inferred ¹⁴
5	PRTN3	Proteinase 3	Protein Coding	7.05	DISEASES inferred ¹⁴
6	ALB	Albumin	Protein Coding	6.92	DISEASES inferred ¹⁴
7	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.75	DISEASES inferred ¹⁴ ¹⁴
8	CRP	C-Reactive Protein	Protein Coding	6.7	DISEASES inferred ¹⁴
9	MPO	Myeloperoxidase	Protein Coding	6.64	DISEASES inferred ¹⁴
10	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	6.58	DISEASES inferred ¹⁴
11	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6.58	DISEASES inferred ¹⁴ ¹⁴
12	MEST	Mesoderm Specific Transcript	Protein Coding	6.49	DISEASES inferred ¹⁴
13	SERPINA3	Serpin Family A Member 3	Protein Coding	6.44	DISEASES inferred ¹⁴ ¹⁴
14	FCAR	Fc Alpha Receptor	Protein Coding	6.42	DISEASES inferred ¹⁴
15	C4B	Complement C4B (Chido Blood Group)	Protein Coding	6.36	DISEASES inferred ¹⁴
16	C4A	Complement C4A (Rodgers Blood Group)	Protein Coding	6.34	DISEASES inferred ¹⁴
17	TNF	Tumor Necrosis Factor	Protein Coding	6.27	DISEASES inferred ¹⁴
18	CFP	Complement Factor Properdin	Protein Coding	6.27	DISEASES inferred ¹⁴
19	IL6	Interleukin 6	Protein Coding	6.18	DISEASES inferred ¹⁴
20	CD4	CD4 Molecule	Protein Coding	6.1	DISEASES inferred ¹⁴
21	ACE	Angiotensin I Converting Enzyme	Protein Coding	6.1	DISEASES inferred ¹⁴
22	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	5.96	DISEASES inferred ¹⁴
23	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	5.93	DISEASES inferred ¹⁴
24	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	5.9	DISEASES inferred ¹⁴
25	FCGR2B	Fc Gamma Receptor IIb	Protein Coding	5.78	DISEASES inferred ¹⁴
26	IL10	Interleukin 10	Protein Coding	5.77	DISEASES inferred ¹⁴

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Variations for Hypersensitivity Reaction Type Iii Disease

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Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

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Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.46	C3 C4A C4B C5AR1 CCR6 CD4
2	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	12.31	CRP CFP CFHR2 C5AR1 C4B C4A
3	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	12.2	IL6 C4B C4A C3 ALB
4	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.01	TNF IL6 C4B C4A
5	Initial triggering of complement ⁶⁶ Show member pathways Alternative complement activation ⁶⁶ Alternative Complement Pathway ⁶⁴ Classical antibody-mediated complement activation ⁶⁶ Complement activation ⁷⁴ Complement Activation Pathways ⁶⁷ Creation of C4 and C2 activators ⁶⁶ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁶ Lectin pathway of complement activation ⁶⁶	11.86	C3 C4A C4B C5AR1 CFP CRP
6	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.83	TNF MPO IL6 CD79A CD4
7	Immune response Lectin induced complement pathway ²² Show member pathways Immune response Alternative complement pathway ²² Immune response Classical complement pathway ²² Terminal pathway of complement ⁶⁶	11.77	CRP CFP C5AR1 C4B C4A C3
8	Allograft rejection ⁷⁴	11.73	TNF C4B C4A C3
9	Innate Lymphoid Cells Differentiation ⁶⁵	11.65	TNF CD4 CCR6
10	C-MYB transcription factor network ⁶¹	11.64	PRTN3 MPO CD4
11	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.61	IL6 CRP CD4
12	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.58	TNF IL6 CD4
13	Oxidative damage response ⁷⁴	11.27	TNF C5AR1 C4B
14	Cytokines and inflammatory response ⁷⁴	11.12	CD4 IL6 TNF
15	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.08	TNF IL6 ICOSLG CRP CD79A C4B
16	Overview of nanoparticle effects ⁷⁴	10.86	TNF IL6 CRP
17	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.22	TNF IL6

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GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.07	ALB C3 C4A C4B CFHR2 CFP
2	endoplasmic reticulum lumen	GO:0005788	10.03	IL6 CFP CD4 C4A C3 ALB
3	azurophil granule lumen	GO:0035578	9.92	SERPINA3 PRTN3 MPO C3
4	blood microparticle	GO:0072562	9.85	ALB C3 C4A C4B SERPINA3
5	extracellular space	GO:0005615	9.7	TNF SERPINA3 PRTN3 MPO IL6 CRP

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.17	C3 C5AR1 CCR6 CD4 CFP FCAR
2	defense response to Gram-positive bacterium	GO:0050830	10.08	TNF IL6 CRP C5AR1
3	acute-phase response	GO:0006953	9.93	SERPINA3 IL6 CRP
4	positive regulation of vascular endothelial growth factor production	GO:0010575	9.91	IL6 C5AR1 C3
5	inflammatory response	GO:0006954	9.91	C3 C4A C4B C5AR1 CRP IL6
6	negative regulation of lipid storage	GO:0010888	9.85	TNF IL6 CRP
7	immune system process	GO:0002376	9.76	MEFV ICOSLG CFP CD79A CD4 C4B
8	positive regulation of apoptotic cell clearance	GO:2000427	9.73	C4B C4A C3
9	response to gold nanoparticle	GO:1990268	9.71	TNF MPO
10	complement activation	GO:0006956	9.32	CFP CFHR2 C4B C4A C3

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endopeptidase inhibitor activity	GO:0004866	9.1	C4B C4A C3

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Sources for Hypersensitivity Reaction Type Iii Disease

¹ BitterDB

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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³⁰ HPO

³¹ ICD10

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³⁵ IUPHAR

³⁶ LifeMap

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⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: HYP072 MIFTS: 41	Hypersensitivity Reaction Type Iii Disease Categories: Cancer diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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