MCID: HYP072
MIFTS: 39

Hypersensitivity Reaction Type Iii Disease

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease 12 15
Immune Complex Diseases 54 44 70
Type Iii Hypersensitivity Reaction Disease 17
Immune Complex Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1557
MeSH 44 D007105
UMLS 70 C0020951

Summaries for Hypersensitivity Reaction Type Iii Disease

Disease Ontology : 12 A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury.

MalaCards based summary : Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to arthus reaction and membranoproliferative glomerulonephritis. An important gene associated with Hypersensitivity Reaction Type Iii Disease is C5AR1 (Complement C5a Receptor 1), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Vaccines and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and kidney, and related phenotypes are Reduced mammosphere formation and immune system

Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)
# Related Disease Score Top Affiliating Genes
1 arthus reaction 32.1 TNF FCGR1A C5AR1 ALB
2 membranoproliferative glomerulonephritis 31.5 CFP CFHR2 CD79A C4A C3 ALB
3 proliferative glomerulonephritis 30.5 MPO IL6 C3
4 glomerulonephritis 30.3 PRTN3 MPO CFP CD79A C4B C4A
5 immune-complex glomerulonephritis 30.3 MPO ICOSLG CFHR2 C4B C3 ALB
6 cryoglobulinemia 30.3 TNF IL6 CD79A
7 anemia, autoimmune hemolytic 30.2 ICOSLG CCR6 C3
8 primary biliary cholangitis 30.1 PRTN3 ICOSLG CD79A CCR6 ALB
9 pustulosis palmaris et plantaris 30.1 TNF CD79A CCR6
10 complement deficiency 30.1 CFP CFHR2 C5AR1 C4B C4A C3
11 hypersensitivity vasculitis 30.1 TNF SERPINA3 PRTN3 MPO MIR98 MEFV
12 purpura 30.0 TNF MEFV IL6 CRP CD79A C3
13 cholera 30.0 TNF SERPINA3 IL6 CD79A
14 membranous nephropathy 30.0 TNF MPO IL6 CD79A C3 ALB
15 thyroiditis 29.9 TNF IL6 CRP
16 pasteurellosis 29.9 TNF SERPINA3 MPO ALB
17 lupus erythematosus 29.9 TNF FCGR1A C4B C4A C3
18 enthesopathy 29.9 TNF MEFV CRP CCR6
19 extrinsic allergic alveolitis 29.9 MPO IL6 CCR6 ALB
20 chronic granulomatous disease 29.8 TNF MPO CFP CD79A
21 myeloma, multiple 29.8 TNF IL6 ICOSLG CCR6 ALB
22 allergic disease 29.8 TNF MPO IL6 ICOSLG CCR6
23 typhoid fever 29.8 TNF IL6 CRP CCR6 ALB
24 nephrotic syndrome 29.8 TNF IL6 CRP CD79A C3 ALB
25 leprosy 3 29.8 TNF IL6 CCR6 ALB
26 synovitis 29.8 TNF PRTN3 IL6 CRP
27 goodpasture syndrome 29.8 PRTN3 MPO CFP CCR6 ALB
28 endocarditis 29.8 TNF IL6 CRP ALB
29 uremia 29.7 TNF IL6 CRP ALB
30 kawasaki disease 29.7 TNF IL6 CRP ALB
31 spondylitis 29.7 TNF IL6 ICOSLG CRP CCR6
32 viral hepatitis 29.6 TNF SERPINA3 IL6 CRP ALB
33 otitis media 29.5 TNF MPO IL6 CRP CD79A C3
34 migraine with or without aura 1 29.5 TNF IL6 CRP ALB
35 vasculitis 29.5 TNF SERPINA3 PRTN3 MPO MEFV IL6
36 acquired immunodeficiency syndrome 29.5 TNF IL6 CRP CD79A CCR6 ALB
37 liver cirrhosis 29.5 TNF SERPINA3 IL6 CRP ALB
38 neutropenia 29.4 TNF MPO IL6 CRP C5AR1 ALB
39 thrombocytopenia 29.4 TNF IL6 FCGR1A CRP CD79A C3
40 temporal arteritis 29.3 TNF SERPINA3 PRTN3 MPO IL6 CRP
41 connective tissue disease 29.2 TNF SERPINA3 IL6 ICOSLG CRP CFHR2
42 lung disease 29.1 TNF SERPINA3 PRTN3 MPO IL6 CRP
43 autoimmune disease 29.1 TNF PRTN3 MPO IL6 ICOSLG CRP
44 exanthem 29.1 TNF PRTN3 MEFV IL6 ICOSLG CRP
45 spondyloarthropathy 1 29.1 TNF PRTN3 IL6 ICOSLG FCAR CRP
46 skin disease 29.0 TNF SERPINA3 PRTN3 MPO IL6 ICOSLG
47 deficiency anemia 29.0 TNF SERPINA3 PRTN3 IL6 ICOSLG CRP
48 iga glomerulonephritis 28.6 PRTN3 MEFV IL6 FCAR CFP CFHR2
49 systemic lupus erythematosus 28.2 TNF PRTN3 MPO IL6 ICOSLG FCGR1A
50 c1q deficiency 11.0

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:



Diseases related to Hypersensitivity Reaction Type Iii Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ALB C3 C4A C5AR1 CCR6 CD79A

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.47 ALB C3 C4B C5AR1 CCR6 CD79A

Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Drugs for Hypersensitivity Reaction Type Iii Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies Recruiting NCT03277703 Phase 2

Search NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

Genetic Tests for Hypersensitivity Reaction Type Iii Disease

Anatomical Context for Hypersensitivity Reaction Type Iii Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

40
Heart, Bone, Kidney, Skin, Lung, Eye, Placenta

Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show top 50) (show all 210)
# Title Authors PMID Year
1
Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. 61 54
12869020 2003
2
Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. 61 54
10395696 1999
3
Illuminating the in vitro effects of Epstein-Barr virus and vitamin D on immune response in multiple sclerosis patients. 61
33666884 2021
4
Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease. 61
32553251 2020
5
[Dermatomyositis combined with IgA vasculitis: A case report]. 61
31848525 2019
6
[Cutaneous alterations in vasculitides : Part 2: Special aspects of diseases of large, medium and small vessels]. 61
31300830 2019
7
Kidney disease in patients with obesity: It is not always obesity-related glomerulopathy alone. 61
28442280 2017
8
[THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE]. 61
29975827 2017
9
Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. 61
26551683 2015
10
[Genotoxic stress and the pathways of thymus cell death and lymph nodes of mice in conditions of immunocomplex pathology]. 61
26040032 2015
11
Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. 61
23595413 2013
12
[Vasculitis and vasculopathy]. 61
23193816 2012
13
[Systemic lupus erythematosus and pregnancy]. 61
23236665 2012
14
Quantification of immune deposits in renal diseases. 61
21606839 2011
15
Renal AA amyloidosis in a patient with hereditary complete complement C4 deficiency. 61
21912034 2011
16
Effect of academic psychological stress in post-graduate students: the modulatory role of cortisol on superoxide release by neutrophils. 61
21443430 2011
17
Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets. 61
20886107 2010
18
Risks and complications of vasectomy. 61
19643235 2009
19
Molecular bases of immune complex pathology. 61
19538120 2009
20
Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. 61
19852746 2009
21
Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patient. 61
19013325 2008
22
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. 61
17684013 2007
23
TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells. 61
17495424 2007
24
Anaphylatoxins: their role in bacterial infection and inflammation. 61
17873401 2007
25
Anti-C1q antibodies in hepatitis C virus infection. 61
16879251 2006
26
Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. 61
16167082 2005
27
Mechanisms of immune-deposit formation and the mediation of immune renal injury. 61
16189625 2005
28
[Investigation of the complement system in clinical practice]. 61
15037829 2003
29
Monoclonal gammopathy: significance and possible causality in renal disease. 61
12830460 2003
30
Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack. 61
12374811 2002
31
A full complement of receptors in immune complex diseases. 61
12488423 2002
32
Endothelin levels in Henoch-Schonlein purpura. 54
12432435 2002
33
Susceptibility to T cell-mediated injury in immune complex disease is linked to local activation of renin-angiotensin system: the role of NF-AT pathway. 61
12370342 2002
34
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. 61
12379763 2002
35
Specific inhibition of the classical complement pathway by C1q-binding peptides. 61
11739526 2001
36
Enhancement of splenic-macrophage Fcgamma receptor expression by treatment with estrogens. 61
11427431 2001
37
Cryoglobulinemia. 61
10626153 1999
38
Precipitated immune complexes of IgM induce the generation of reactive oxygen species by rabbit polymorphonuclear leucocytes. 61
9698825 1998
39
Risk and safety of immunotherapy. 61
9636805 1998
40
[Immunogerontology--aging of the immune system and its cause]. 61
10021884 1998
41
Glomerular lesions in HIV-infected patients: a Yale University Department of Medicine Residency Peer-Teaching Conference. 61
9493848 1997
42
Polymorphism of the fourth component of complement (C4) and three clinical pictures of hepatitis B virus infection in children. 61
9523004 1997
43
[Lupus erythematosus systemic and persistent pulmonary salmonellosis]. 61
9011888 1996
44
Frequency of complement third component (C3) and properdin factor (BF) phenotypes in patients with various clinical manifestations of HBV infection. 61
8834917 1996
45
Pharmacological effects of oral enzyme combinations. 61
7585874 1995
46
[Systemic enzyme therapy in diseases of the vascular system]. 61
8620329 1995
47
Partial C4 deficiency in two children with systemic lupus erythematosus. 61
7597765 1995
48
Physiology and pathophysiology of complement: progress and trends. 61
7495498 1995
49
Expression of receptors for advanced glycosylated end-products in renal disease. 61
8559486 1995
50
[Today's apheresis therapy]. 61
7744369 1995

Variations for Hypersensitivity Reaction Type Iii Disease

Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 TNF SERPINA3 PRTN3 MPO MEFV IL6
2
Show member pathways
12.71 TNF IL6 ICOSLG C4A C3
3
Show member pathways
12.13 TNF SERPINA3 MPO IL6 CRP ALB
4 12.1 TNF IL6 FCGR1A C3
5 12.03 TNF IL6 C4B C4A
6 11.99 MPO FCGR1A FCAR C3
7
Show member pathways
11.96 CRP C5AR1 C4B C4A C3
8 11.93 CFHR2 C5AR1 C4B C4A C3
9 11.86 TNF MPO IL6 CD79A
10
Show member pathways
11.83 CRP CFP C5AR1 C4B C4A C3
11
Show member pathways
11.67 CFP C4B C4A C3
12 11.55 TNF IL6 ICOSLG CCR6
13 11.54 TNF IL6 C4B C4A C3
14 11.49 TNF IL6 C3
15 11.42 FCGR1A FCAR C5AR1 C4B C4A C3
16 11.39 TNF MPO IL6
17 10.93 TNF IL6 CRP

GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF SERPINA3 PRTN3 MPO IL6 FCAR
2 endoplasmic reticulum lumen GO:0005788 9.72 IL6 CFP C4A C3 ALB
3 azurophil granule lumen GO:0035578 9.56 SERPINA3 PRTN3 MPO C3
4 blood microparticle GO:0072562 9.55 SERPINA3 C4B C4A C3 ALB
5 extracellular space GO:0005615 9.4 TNF SERPINA3 PRTN3 MPO MIR98 IL6

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.01 MEFV ICOSLG FCGR1A CFP CD79A C4B
2 innate immune response GO:0045087 9.98 MEFV FCGR1A CRP CFP C4B C4A
3 cellular protein metabolic process GO:0044267 9.88 IL6 C4A C3 ALB
4 neutrophil degranulation GO:0043312 9.87 SERPINA3 PRTN3 MPO FCAR CFP C5AR1
5 complement activation, classical pathway GO:0006958 9.84 CRP C4B C4A C3
6 negative regulation of endopeptidase activity GO:0010951 9.83 SERPINA3 C4B C4A C3
7 defense response to Gram-positive bacterium GO:0050830 9.78 TNF IL6 CRP C5AR1
8 complement activation GO:0006956 9.76 CFP C4B C4A C3
9 immune response GO:0006955 9.76 TNF IL6 FCGR1A FCAR CFP CCR6
10 humoral immune response GO:0006959 9.72 TNF IL6 CCR6
11 acute-phase response GO:0006953 9.69 SERPINA3 IL6 CRP
12 positive regulation of vascular endothelial growth factor production GO:0010575 9.67 IL6 C5AR1 C3
13 neutrophil mediated immunity GO:0002446 9.59 IL6 FCAR
14 response to peptidoglycan GO:0032494 9.58 IL6 C5AR1
15 vascular endothelial growth factor production GO:0010573 9.57 TNF IL6
16 opsonization GO:0008228 9.56 CRP C4B
17 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
18 positive regulation of apoptotic cell clearance GO:2000427 9.43 C4B C4A C3
19 regulation of complement activation GO:0030449 9.43 CFP CFHR2 C5AR1 C4B C4A C3
20 inflammatory response GO:0006954 9.28 TNF SERPINA3 MEFV IL6 CRP C5AR1

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement component C1q binding GO:0001849 8.96 CRP C4A
2 endopeptidase inhibitor activity GO:0004866 8.8 C4B C4A C3

Sources for Hypersensitivity Reaction Type Iii Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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