MCID: HYP072
MIFTS: 45

Hypersensitivity Reaction Type Iii Disease

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease 12 15
Immune Complex Diseases 55 44 73
Immune Complex Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1557
MeSH 44 D007105
UMLS 73 C0020951

Summaries for Hypersensitivity Reaction Type Iii Disease

MalaCards based summary : Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to membranoproliferative glomerulonephritis and viral infectious disease. An important gene associated with Hypersensitivity Reaction Type Iii Disease is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. Affiliated tissues include kidney, monocytes and bone, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 membranoproliferative glomerulonephritis 31.2 ALB C3 C4A CD79A ICAM1
2 viral infectious disease 29.6 IL6 TLR9 TNF
3 pustulosis palmaris et plantaris 29.3 CD79A SELE TNF
4 lupus erythematosus 29.3 C3 C4A C4B TNF
5 palindromic rheumatism 29.3 CRP MEFV TNF
6 rheumatoid arthritis 29.0 CRP ICAM1 IL6 SELE TNF
7 myeloma, multiple 29.0 ALB CRP HSP90AA1 IL6 TLR9 TNF
8 vasculitis 28.5 CRP ICAM1 MEFV MPO SELE TNF
9 glomerulonephritis 28.5 ALB C3 C4A C4B CD79A ICAM1
10 systemic lupus erythematosus 27.5 ALB C3 C4A C4B CD79A CRP
11 c1q deficiency 10.9
12 complement component c1s deficiency 10.9
13 focal dermal hypoplasia 10.3 ALB CD79A
14 parotitis 10.3 ALB CD79A
15 root caries 10.3 ALB CD79A
16 arteriolosclerosis 10.3 C3 CD79A
17 ocular toxoplasmosis 10.3 CD79A TLR9
18 abdominal tuberculosis 10.3 ALB CRP
19 pyuria 10.3 ALB CRP
20 gastrointestinal tuberculosis 10.3 ALB CRP
21 decubitus ulcer 10.3 ALB CRP
22 acute maxillary sinusitis 10.3 C3 CRP
23 acquired angioedema 10.3 C3 CRP
24 phototoxic dermatitis 10.2 C3 ICAM1
25 autoimmune glomerulonephritis 10.2 ICAM1 TLR9
26 complement factor i deficiency 10.2 C3 C4B
27 eye lymphoma 10.2 IL6 TLR9
28 epilepsy, familial temporal lobe, 2 10.2 C4A C4B
29 hymenolepiasis 10.2 ICAM1 SELE
30 mooren's ulcer 10.2 ICAM1 SELE
31 juvenile dermatitis herpetiformis 10.2 C4A C4B
32 monoclonal paraproteinemia 10.2 HSP90AA1 MPO
33 lymphocytic vasculitis 10.2 ICAM1 SELE
34 immunodeficiency due to a classical component pathway complement deficiency 10.2 C4A C4B
35 neutrophilia, hereditary 10.2 CRP IL6
36 acute cholangitis 10.2 CRP IL6
37 pasteurellosis 10.2 ALB MPO
38 cold agglutinin disease 10.2 CRP IL6
39 cryopyrin-associated periodic syndrome 10.2 CRP IL6
40 uremic pruritus 10.2 CRP IL6
41 orthostatic proteinuria 10.2 ALB C3 HSP90AA1
42 chronic monocytic leukemia 10.2 C3 MPO
43 mononeuritis multiplex 10.1 CRP MPO
44 aortitis 10.1 CRP MPO
45 mediastinitis 10.1 CRP MPO
46 pericardium disease 10.1 ALB CRP MEFV
47 iga glomerulonephritis 10.1 ALB CD79A IL6
48 cow milk allergy 10.1 CD79A TNF
49 autoinflammation, panniculitis, and dermatosis syndrome 10.1 MEFV TNF
50 systemic scleroderma 10.1 CRP SELE TLR9

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:



Diseases related to Hypersensitivity Reaction Type Iii Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB C3 C4A CD79A HSP90AA1 SELE

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 ALB C3 CD79A HSP90AA1 ICAM1 IL6
2 homeostasis/metabolism MP:0005376 10.1 ALB C3 C4B CD79A CRP ICAM1
3 hematopoietic system MP:0005397 10.07 C3 C4B CD79A ICAM1 IL6 MEFV
4 cardiovascular system MP:0005385 10.06 C3 C4B CRP ICAM1 IL6 MPO
5 immune system MP:0005387 10.03 C3 C4B CD79A CRP HSP90AA1 ICAM1
6 digestive/alimentary MP:0005381 9.95 ALB C3 C4B ICAM1 IL6 TLR9
7 liver/biliary system MP:0005370 9.76 ALB C3 C4B CD79A IL6 MEFV
8 mortality/aging MP:0010768 9.7 ALB C3 C4B HSP90AA1 ICAM1 IL6
9 renal/urinary system MP:0005367 9.1 ALB C3 C4B CD79A IL6 TLR9

Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

Genetic Tests for Hypersensitivity Reaction Type Iii Disease

Anatomical Context for Hypersensitivity Reaction Type Iii Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

41
Kidney, Monocytes, Bone, Heart, Lymph Node, Eye, Spinal Cord

Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show all 32)
# Title Authors Year
1
Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. ( 19852746 )
2009
2
A full complement of receptors in immune complex diseases. ( 12488423 )
2002
3
[Therapeutic plasmapheresis in immune complex diseases]. ( 7985137 )
1994
4
Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases. ( 8098488 )
1993
5
Immune complex diseases. ( 8424984 )
1993
6
Immune complex diseases. ( 2151123 )
1990
7
Cationic polyelectrolytes: a new look at their possible roles as opsonins, as stimulators of respiratory burst in leukocytes, in bacteriolysis, and as modulators of immune-complex diseases (a review hypothesis). ( 2961690 )
1987
8
Complement and immune complex diseases. ( 2944500 )
1986
9
Detection of complement activation in immune complex diseases: six methods compared. ( 2946496 )
1986
10
Neutrophil-mediated cellular cytotoxicity triggered by immobilized aggregated IgG: an in vitro model of cell injury during immune complex diseases. ( 6096393 )
1984
11
Treatment of immune complex diseases. ( 6239985 )
1984
12
Complement-mediated inhibition of immune precipitation in patients with immune complex diseases. ( 6220848 )
1983
13
Plasma exchange and immune complex diseases: the predictability of immune complexes removal to clinical response. ( 6460383 )
1982
14
Plasmapheresis in patients with leukaemia, multiple myeloma and immune complex diseases. ( 6454615 )
1981
15
The effect of plasma exchange on the in vitro monocyte function of patients with immune complex diseases. ( 6459197 )
1981
16
Factors influencing the development of immune-complex diseases. ( 6461275 )
1981
17
Is autoimmunity a common denominator in immune complex diseases? ( 6101634 )
1980
18
Pathopysiological aspects of immune complex diseases. Part II. Phagocytosis, exocytosis, and pathogenic depositions. ( 6447230 )
1980
19
Plasmapheresis in patients with leukaemia, multiple myeloma and immune complex diseases. ( 6449819 )
1980
20
Coexisting immune complex diseases in atopy. ( 6449893 )
1980
21
Biochemical aspects of immune complex formation and immune complex diseases. ( 6451188 )
1980
22
Pathophysiologicl aspects of immune complex diseases part i. interaction with plasma enzyme systems, cell membranes and the immune response. ( 7392533 )
1980
23
A nephelometric study of the reaction of monoclonal rheumatoid factor with heat aggregated gamma globulin and sera from patients with immune complex diseases. ( 92379 )
1979
24
Serum complement profile in human leprosy and its comparison with immune complex diseases. ( 147246 )
1977
25
Editorial: Are the inflammatory bowel diseases immune complex diseases? ( 128486 )
1976
26
Proceedings: Models of immune complex diseases and the role of antibody affinity. ( 129487 )
1976
27
Canine immune complex diseases. ( 136591 )
1976
28
Immunity. II. Immune complex diseases. ( 4277523 )
1974
29
Immune complex diseases. ( 4264709 )
1972
30
Virus-associated immunopathology: animal models and implications for human disease. 1. Effects of viruses on the immune system, immune-complex diseases, and antibody-mediated immunologic injury. ( 4404992 )
1972
31
Immune complex diseases. I. Pathological changes in the kidneys of BALB-c mice neonatally infected with Moloney leukaemogenic and murine sarcoma viruses. ( 4333814 )
1971
32
Immune complex diseases. ( 4398333 )
1971

Variations for Hypersensitivity Reaction Type Iii Disease

Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 C3 C4A C4B CD79A CRP HSP90AA1
2
Show member pathways
12.92 C3 HSP90AA1 IL6 MEFV TLR9 TNF
3
Show member pathways
12.77 C3 C4A HSP90AA1 ICAM1 IL6 TNF
4
Show member pathways
12.71 C3 ICAM1 IL6 TLR9 TNF
5 12.46 CD79A MPO TLR9 TNF
6 12.16 C3 IL6 TLR9 TNF
7 12.11 C4A C4B IL6 TNF
8
Show member pathways
12.07 ALB CRP ICAM1 IL6 MPO TNF
9
Show member pathways
12.05 C3 C4A C4B CRP
10 12.02 HSP90AA1 ICAM1 SELE TNF
11
Show member pathways
12 C3 C4A C4B CRP
12 11.98 C3 C4A C4B
13
Show member pathways
11.94 IL6 TLR9 TNF
14 11.91 ICAM1 IL6 TNF
15 11.91 CD79A IL6 MPO TNF
16 11.89 HSP90AA1 ICAM1 IL6 TNF
17 11.87 ICAM1 IL6 SELE TNF
18
Show member pathways
11.85 C3 C4A C4B
19 11.81 ICAM1 IL6 SELE TNF
20 11.77 ICAM1 IL6 TNF
21 11.69 HSP90AA1 ICAM1 IL6 SELE
22 11.68 IL6 TLR9 TNF
23 11.54 C3 IL6 TNF
24
Show member pathways
11.53 ICAM1 IL6 SELE TNF
25 11.5 HSP90AA1 IL6 TNF
26 11.48 ICAM1 IL6 TNF
27 11.45 C3 C4A C4B ICAM1
28 11.43 C3 C4A C4B IL6 TNF
29 11.35 ICAM1 IL6 MPO TNF
30 11.04 ICAM1 IL6 SELE TLR9 TNF
31 10.95 CRP IL6 TNF
32 10.84 ICAM1 MPO TNF
33 10.57 ICAM1 IL6 SELE TLR9 TNF

GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ALB C3 C4A C4B HSP90AA1 ICAM1
2 extracellular region GO:0005576 9.65 ALB C3 C4A C4B CRP HSP90AA1
3 endoplasmic reticulum lumen GO:0005788 9.62 ALB C3 C4A IL6
4 membrane raft GO:0045121 9.56 CD79A ICAM1 SELE TNF
5 blood microparticle GO:0072562 9.46 ALB C3 C4A C4B
6 extracellular space GO:0005615 9.32 ALB C3 C4A C4B CRP ICAM1

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.89 ALB C3 C4A IL6
2 cytokine-mediated signaling pathway GO:0019221 9.87 HSP90AA1 ICAM1 IL6 TNF
3 immune system process GO:0002376 9.85 C3 C4A C4B CD79A MEFV TLR9
4 cellular protein metabolic process GO:0044267 9.8 ALB C3 C4A IL6
5 innate immune response GO:0045087 9.8 C3 C4A C4B CRP MEFV TLR9
6 regulation of complement activation GO:0030449 9.77 C3 C4A C4B
7 defense response to Gram-positive bacterium GO:0050830 9.76 CRP IL6 TNF
8 complement activation GO:0006956 9.75 C3 C4A C4B
9 complement activation, classical pathway GO:0006958 9.73 C3 C4A C4B CRP
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.72 HSP90AA1 IL6 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 ICAM1 IL6 TLR9 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.65 IL6 TLR9 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 HSP90AA1 ICAM1 TNF
14 leukocyte tethering or rolling GO:0050901 9.62 SELE TNF
15 positive regulation of glial cell proliferation GO:0060252 9.61 IL6 TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.61 MPO TNF
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.56 TLR9 TNF
18 opsonization GO:0008228 9.54 C4B CRP
19 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 ICAM1 TNF
20 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
21 positive regulation of chemokine production GO:0032722 9.43 IL6 TLR9 TNF
22 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
23 inflammatory response GO:0006954 9.28 C3 C4A C4B CRP IL6 MEFV
24 positive regulation of apoptotic cell clearance GO:2000427 9.13 C3 C4A C4B

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.26 CD79A ICAM1 SELE TLR9
2 complement component C1q binding GO:0001849 9.16 C4A CRP
3 endopeptidase inhibitor activity GO:0004866 8.8 C3 C4A C4B

Sources for Hypersensitivity Reaction Type Iii Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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