MCID: HYP072
MIFTS: 41

Hypersensitivity Reaction Type Iii Disease

Categories: Cancer diseases, Immune diseases
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Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease 11 14
Immune Complex Diseases 53 43 71
Type Iii Hypersensitivity Reaction Disease 16
Immune Complex Disease 11

Classifications:



External Ids:

Disease Ontology 11 DOID:1557
MeSH 43 D007105
UMLS 71 C0020951

Summaries for Hypersensitivity Reaction Type Iii Disease

Disease Ontology: 11 A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury.

MalaCards based summary: Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to arthus reaction and membranous nephropathy. An important gene associated with Hypersensitivity Reaction Type Iii Disease is C5AR1 (Complement C5a Receptor 1), and among its related pathways/superpathways are Innate Immune System and Complement cascade. The drugs Vaccines and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and neutrophil, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 907)
# Related Disease Score Top Affiliating Genes
1 arthus reaction 32.4 TNF C5AR1 ALB
2 membranous nephropathy 30.6 CFHR2 CD79A ALB
3 lupus erythematosus 30.5 CCR6 C4B C4A C3
4 purpura 30.3 TNF IL6 CRP CD79A C3
5 cryoglobulinemia 30.3 TNF IL6 CD79A
6 hypersensitivity vasculitis 30.2 TNF SERPINA3 PRTN3 MPO MEST MEFV
7 thrombocytopenia due to platelet alloimmunization 30.2 ICOSLG CD4 CCR6
8 palindromic rheumatism 30.2 PRTN3 MEFV CRP
9 lipoid nephrosis 30.1 SERPINA3 CD79A ALB
10 libman-sacks endocarditis 30.1 PRTN3 CRP CFHR2 C3
11 immune-complex glomerulonephritis 30.1 PRTN3 ICOSLG CFP CFHR2 CD4 C3
12 complement deficiency 30.1 CFP CFHR2 C5AR1 C4B C4A C3
13 pasteurellosis 30.1 SERPINA3 MPO CFHR2 ALB
14 neutrophilia, hereditary 30.0 MPO IL6 CRP
15 liver cirrhosis 30.0 TNF SERPINA3 IL6 ALB
16 thyroiditis 30.0 TNF IL6 CRP
17 cholera 30.0 TNF SERPINA3 IL6 CD79A
18 acute kidney failure 30.0 PRTN3 IL6 ALB
19 lepromatous leprosy 30.0 TNF CD4 CCR6
20 thrombocytopenic purpura, autoimmune 30.0 ICOSLG CD4 CCR6
21 typhoid fever 30.0 TNF IL6 CRP CCR6 ALB
22 viral infectious disease 30.0 TNF SERPINA3 IL6 ICOSLG CD4 CCR6
23 arthropathy 29.9 TNF IL6 CRP CCR6
24 proliferative glomerulonephritis 29.9 PRTN3 MPO ICOSLG CFHR2 CD79A CCR6
25 endocarditis 29.9 TNF IL6 CRP ALB
26 synovitis 29.9 TNF PRTN3 IL6 CRP
27 mesangial proliferative glomerulonephritis 29.9 IL6 CFHR2 CD79A C3 ALB
28 urticaria 29.9 TNF IL6 CRP CD4
29 spondylitis 29.9 TNF IL6 CRP CCR6
30 viral hepatitis 29.9 MPO IL6 CRP ALB
31 extrinsic allergic alveolitis 29.9 TNF CD4 CCR6
32 hepatitis a 29.9 TNF CD4 ALB
33 eclampsia 29.9 TNF IL6 ALB
34 uremia 29.8 TNF IL6 CRP ALB
35 monoclonal gammopathy of uncertain significance 29.8 IL6 ICOSLG CFHR2 CCR6 ALB
36 pfeiffer syndrome 29.8 TNF CRP CD4 CCR6
37 vasculitis 29.8 TNF SERPINA3 PRTN3 MPO MEFV IL6
38 myocarditis 29.7 TNF IL6 CD4 ALB
39 psoriatic arthritis 29.7 TNF IL6 ICOSLG CRP CCR6
40 chronic granulomatous disease 29.7 TNF MPO CFP CD4
41 otitis media 29.7 TNF MPO IL6 CRP CD79A C3
42 common variable immunodeficiency 29.7 TNF MPO IL6 ICOSLG CD79A
43 migraine with or without aura 1 29.6 TNF SERPINA3 IL6 CRP ALB
44 arthritis 29.6 TNF MEFV IL6 CRP CCR6 ALB
45 allergic disease 29.6 TNF SERPINA3 IL6 ICOSLG CD4 CCR6
46 glomerulonephritis 29.6 TNF PRTN3 MPO IL6 FCAR CRP
47 bell's palsy 29.6 TNF IL6 CRP CD4 ALB
48 neutropenia 29.6 TNF MPO IL6 CRP C5AR1 ALB
49 polyarteritis nodosa 29.6 TNF PRTN3 MPO MEFV IL6 CRP
50 portal hypertension 29.6 TNF CCR6 ALB

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:



Diseases related to Hypersensitivity Reaction Type Iii Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB C3 C4A C5AR1 CCR6 CD79A

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 ALB C3 C4A C4B C5AR1 CCR6
2 liver/biliary system MP:0005370 9.92 ALB C3 C4A C4B CD79A IL6
3 cardiovascular system MP:0005385 9.9 ALB C3 C4A C4B CCR6 CFP
4 immune system MP:0005387 9.89 ALB C3 C4A C4B C5AR1 CCR6
5 hematopoietic system MP:0005397 9.47 C3 C4A C4B C5AR1 CCR6 CD4

Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Drugs for Hypersensitivity Reaction Type Iii Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies Completed NCT03277703 Phase 2

Search NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

Genetic Tests for Hypersensitivity Reaction Type Iii Disease

Anatomical Context for Hypersensitivity Reaction Type Iii Disease

Organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

MalaCards : Kidney, Lung, Neutrophil, Smooth Muscle, Bone Marrow, T Cells, Liver

Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show top 50) (show all 786)
# Title Authors PMID Year
1
Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. 53 62
12869020 2003
2
Endothelin levels in Henoch-Schonlein purpura. 53 62
12432435 2002
3
Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. 53 62
10395696 1999
4
Pathogenesis of idiopathic IgA nephropathy. 53 62
8518104 1993
5
Triple-threat quantitative multiplexed plasma proteomics analysis on immune complex disease MRL-lpr mice. 62
35964289 2022
6
[Cryoglobulinemic vasculitis]. 62
35258723 2022
7
A Case of Focal Segmental Glomerulosclerosis With Immune Complexes: Is HIV, Hepatitis B, or Crack the Culprit? 62
34557371 2021
8
Illuminating the in vitro effects of Epstein-Barr virus and vitamin D on immune response in multiple sclerosis patients. 62
33666884 2021
9
BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics. 62
33455525 2021
10
Profiling Biomarkers in HIV Glomerular Disease - Potential for the Non-Invasive Diagnosis of HIVAN? 62
34916827 2021
11
Type 3 hypersensitivity in COVID-19 vasculitis. 62
32479986 2020
12
Inflammatory markers in systemic lupus erythematosus. 62
31812331 2020
13
Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease. 62
32553251 2020
14
Contemporary issues and new challenges in chronic kidney disease amongst people living with HIV. 62
32178687 2020
15
Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates. 62
32325480 2020
16
HIV/AIDS and chronic kidney disease. 62
31397267 2020
17
[Dermatomyositis combined with IgA vasculitis: A case report]. 62
31848525 2019
18
[Cutaneous alterations in vasculitides : Part 2: Special aspects of diseases of large, medium and small vessels]. 62
31300830 2019
19
Patterns of renal disease: A 30-year renal biopsy study at Chris Hani Baragwanath Academic Hospital, Soweto, Johannesburg, South Africa. 62
31266574 2019
20
Immunogenicity and Immune Complex Disease in Preclinical Safety Studies. 62
30157708 2018
21
Drug-induced Glomerulonephritis: The Spectre of Biotherapeutic and Antisense Oligonucleotide Immune Activation in the Kidney. 62
30089413 2018
22
Renal involvement in antiphospholipid syndrome. 62
29730854 2018
23
Amdoparvovirus Infection in Red Pandas ( Ailurus fulgens). 62
29433401 2018
24
Acute Kidney Injury after Pembrolizumab-Induced Adrenalitis and Adrenal Insufficiency. 62
30197906 2018
25
Epstein-Barr virus and rheumatoid arthritis. 62
28499895 2018
26
Nephrotic syndrome due to lupus-like glomerulonephritis in an HIV-positive patient. 62
29219816 2017
27
APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy. 62
29110758 2017
28
Viral-Associated GN: Hepatitis B and Other Viral Infections. 62
27797900 2017
29
Kidney disease in patients with obesity: It is not always obesity-related glomerulopathy alone. 62
28442280 2017
30
Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. 62
28810602 2017
31
Patterns of glomerulonephritis with crescents: Experience at a tertiary medical center in Saudi Arabia. 62
28540889 2017
32
[THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE]. 62
29975827 2017
33
[IgA nephropathy]. 62
27323655 2016
34
Fraternal twins with job's syndrome and immune complex nephritis. 62
28509165 2016
35
Bullous Pemphigoid With a Dual Pattern of Glomerular Immune Complex Disease. 62
26616334 2016
36
Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. 62
26613031 2015
37
Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. 62
26551683 2015
38
Successful and Safe Long-Term Standard Antiviral Therapy in a Patient with "Explosive" Immune Response in Course of HCV-Related Liver Cirrhosis. 62
26101866 2015
39
Vaccination of cattle with the N terminus of LppQ of Mycoplasma mycoides subsp. mycoides results in type III immune complex disease upon experimental infection. 62
25733516 2015
40
HIV and chronic kidney disease. 62
25725239 2015
41
[Genotoxic stress and the pathways of thymus cell death and lymph nodes of mice in conditions of immunocomplex pathology]. 62
26040032 2015
42
Validation of an automated ELISA system for detection of antibodies to Aleutian mink disease virus using blood samples collected in filter paper strips. 62
25103400 2014
43
[Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?]. 62
25272602 2014
44
Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis). 62
24616262 2014
45
Membranous glomerulonephritis with crescents. 62
24217802 2014
46
Necrotizing arteritis in a human immunodeficiency virus-infected patient with lupus-like glomerulonephritis. 62
24427374 2014
47
Transferrin-immune complex disease: a potentially overlooked gammopathy mediated by IgM and IgG. 62
23913829 2013
48
Immune complex disease with a lupus-like pattern of deposition in an antinuclear antibody-negative patient. 62
23548558 2013
49
Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. 62
23595413 2013
50
The clinical and histological response of HIV-associated kidney disease to antiretroviral therapy in South Africans. 62
23444185 2013

Variations for Hypersensitivity Reaction Type Iii Disease

Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 C3 C4A C4B C5AR1 CCR6 CD4
2
Show member pathways
12.31 CRP CFP CFHR2 C5AR1 C4B C4A
3
Show member pathways
12.2 IL6 C4B C4A C3 ALB
4 12.01 TNF IL6 C4B C4A
5
Show member pathways
11.86 C3 C4A C4B C5AR1 CFP CRP
6 11.83 TNF MPO IL6 CD79A CD4
7
Show member pathways
11.77 CRP CFP C5AR1 C4B C4A C3
8 11.73 TNF C4B C4A C3
9 11.65 TNF CD4 CCR6
10 11.64 PRTN3 MPO CD4
11
Show member pathways
11.61 IL6 CRP CD4
12 11.58 TNF IL6 CD4
13 11.27 TNF C5AR1 C4B
14 11.12 CD4 IL6 TNF
15 11.08 TNF IL6 ICOSLG CRP CD79A C4B
16 10.86 TNF IL6 CRP
17
Show member pathways
10.22 TNF IL6

GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.07 ALB C3 C4A C4B CFHR2 CFP
2 endoplasmic reticulum lumen GO:0005788 10.03 IL6 CFP CD4 C4A C3 ALB
3 azurophil granule lumen GO:0035578 9.92 SERPINA3 PRTN3 MPO C3
4 blood microparticle GO:0072562 9.85 ALB C3 C4A C4B SERPINA3
5 extracellular space GO:0005615 9.7 TNF SERPINA3 PRTN3 MPO IL6 CRP

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.17 C3 C5AR1 CCR6 CD4 CFP FCAR
2 defense response to Gram-positive bacterium GO:0050830 10.08 TNF IL6 CRP C5AR1
3 acute-phase response GO:0006953 9.93 SERPINA3 IL6 CRP
4 positive regulation of vascular endothelial growth factor production GO:0010575 9.91 IL6 C5AR1 C3
5 inflammatory response GO:0006954 9.91 C3 C4A C4B C5AR1 CRP IL6
6 negative regulation of lipid storage GO:0010888 9.85 TNF IL6 CRP
7 immune system process GO:0002376 9.76 MEFV ICOSLG CFP CD79A CD4 C4B
8 positive regulation of apoptotic cell clearance GO:2000427 9.73 C4B C4A C3
9 response to gold nanoparticle GO:1990268 9.71 TNF MPO
10 complement activation GO:0006956 9.32 CFP CFHR2 C4B C4A C3

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 9.1 C4B C4A C3

Sources for Hypersensitivity Reaction Type Iii Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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