Hypersensitivity Reaction Type Iii Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP072 MIFTS: 39	Hypersensitivity Reaction Type Iii Disease Categories: Cancer diseases, Immune diseases
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Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease ¹² ¹⁵

Immune Complex Diseases ⁵⁴ ⁴⁴ ⁷⁰

Type Iii Hypersensitivity Reaction Disease ¹⁷

Immune Complex Disease ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1557

MeSH ⁴⁴ D007105

EFO ¹⁷ EFO_1001222

UMLS ⁷⁰ C0020951

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Summaries for Hypersensitivity Reaction Type Iii Disease

Disease Ontology : ¹² A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury.

MalaCards based summary : Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to arthus reaction and membranoproliferative glomerulonephritis. An important gene associated with Hypersensitivity Reaction Type Iii Disease is C5AR1 (Complement C5a Receptor 1), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Vaccines and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and kidney, and related phenotypes are Reduced mammosphere formation and immune system

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Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)

#	Related Disease	Score	Top Affiliating Genes
1	arthus reaction	32.1	TNF FCGR1A C5AR1 ALB
2	membranoproliferative glomerulonephritis	31.5	CFP CFHR2 CD79A C4A C3 ALB
3	proliferative glomerulonephritis	30.5	MPO IL6 C3
4	glomerulonephritis	30.3	PRTN3 MPO CFP CD79A C4B C4A
5	immune-complex glomerulonephritis	30.3	MPO ICOSLG CFHR2 C4B C3 ALB
6	cryoglobulinemia	30.3	TNF IL6 CD79A
7	anemia, autoimmune hemolytic	30.2	ICOSLG CCR6 C3
8	primary biliary cholangitis	30.1	PRTN3 ICOSLG CD79A CCR6 ALB
9	pustulosis palmaris et plantaris	30.1	TNF CD79A CCR6
10	complement deficiency	30.1	CFP CFHR2 C5AR1 C4B C4A C3
11	hypersensitivity vasculitis	30.1	TNF SERPINA3 PRTN3 MPO MIR98 MEFV
12	purpura	30.0	TNF MEFV IL6 CRP CD79A C3
13	cholera	30.0	TNF SERPINA3 IL6 CD79A
14	membranous nephropathy	30.0	TNF MPO IL6 CD79A C3 ALB
15	thyroiditis	29.9	TNF IL6 CRP
16	pasteurellosis	29.9	TNF SERPINA3 MPO ALB
17	lupus erythematosus	29.9	TNF FCGR1A C4B C4A C3
18	enthesopathy	29.9	TNF MEFV CRP CCR6
19	extrinsic allergic alveolitis	29.9	MPO IL6 CCR6 ALB
20	chronic granulomatous disease	29.8	TNF MPO CFP CD79A
21	myeloma, multiple	29.8	TNF IL6 ICOSLG CCR6 ALB
22	allergic disease	29.8	TNF MPO IL6 ICOSLG CCR6
23	typhoid fever	29.8	TNF IL6 CRP CCR6 ALB
24	nephrotic syndrome	29.8	TNF IL6 CRP CD79A C3 ALB
25	leprosy 3	29.8	TNF IL6 CCR6 ALB
26	synovitis	29.8	TNF PRTN3 IL6 CRP
27	goodpasture syndrome	29.8	PRTN3 MPO CFP CCR6 ALB
28	endocarditis	29.8	TNF IL6 CRP ALB
29	uremia	29.7	TNF IL6 CRP ALB
30	kawasaki disease	29.7	TNF IL6 CRP ALB
31	spondylitis	29.7	TNF IL6 ICOSLG CRP CCR6
32	viral hepatitis	29.6	TNF SERPINA3 IL6 CRP ALB
33	otitis media	29.5	TNF MPO IL6 CRP CD79A C3
34	migraine with or without aura 1	29.5	TNF IL6 CRP ALB
35	vasculitis	29.5	TNF SERPINA3 PRTN3 MPO MEFV IL6
36	acquired immunodeficiency syndrome	29.5	TNF IL6 CRP CD79A CCR6 ALB
37	liver cirrhosis	29.5	TNF SERPINA3 IL6 CRP ALB
38	neutropenia	29.4	TNF MPO IL6 CRP C5AR1 ALB
39	thrombocytopenia	29.4	TNF IL6 FCGR1A CRP CD79A C3
40	temporal arteritis	29.3	TNF SERPINA3 PRTN3 MPO IL6 CRP
41	connective tissue disease	29.2	TNF SERPINA3 IL6 ICOSLG CRP CFHR2
42	lung disease	29.1	TNF SERPINA3 PRTN3 MPO IL6 CRP
43	autoimmune disease	29.1	TNF PRTN3 MPO IL6 ICOSLG CRP
44	exanthem	29.1	TNF PRTN3 MEFV IL6 ICOSLG CRP
45	spondyloarthropathy 1	29.1	TNF PRTN3 IL6 ICOSLG FCAR CRP
46	skin disease	29.0	TNF SERPINA3 PRTN3 MPO IL6 ICOSLG
47	deficiency anemia	29.0	TNF SERPINA3 PRTN3 IL6 ICOSLG CRP
48	iga glomerulonephritis	28.6	PRTN3 MEFV IL6 FCAR CFP CFHR2
49	systemic lupus erythematosus	28.2	TNF PRTN3 MPO IL6 ICOSLG FCGR1A
50	c1q deficiency	11.0

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:

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Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.23	ALB C3 C4A C5AR1 CCR6 CD79A

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.47	ALB C3 C4B C5AR1 CCR6 CD79A

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Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Drugs for Hypersensitivity Reaction Type Iii Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Vaccines		Phase 2
2	Immunosuppressive Agents		Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies	Recruiting	NCT03277703	Phase 2

Search NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

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Genetic Tests for Hypersensitivity Reaction Type Iii Disease

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Anatomical Context for Hypersensitivity Reaction Type Iii Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

⁴⁰

Heart, Bone, Kidney, Skin, Lung, Eye, Placenta

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Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show top 50) (show all 210)

#	Title	Authors	PMID	Year
1	Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. ⁶¹ ⁵⁴	Fung M...Mollnes TE	12869020	2003
2	Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. ⁶¹ ⁵⁴	Heller T...Kohl J	10395696	1999
3	Illuminating the in vitro effects of Epstein-Barr virus and vitamin D on immune response in multiple sclerosis patients. ⁶¹	Teymoori-Rad M...Marashi SM	33666884	2021
4	Novel Complement Therapeutics in Development as Potential Treatment for Renal Disease. ⁶¹	Kelleher C...Kocinsky H	32553251	2020
5	[Dermatomyositis combined with IgA vasculitis: A case report]. ⁶¹	Xu J...Li SG	31848525	2019
6	[Cutaneous alterations in vasculitides : Part 2: Special aspects of diseases of large, medium and small vessels]. ⁶¹	Sunderkotter C...Michl C	31300830	2019
7	Kidney disease in patients with obesity: It is not always obesity-related glomerulopathy alone. ⁶¹	Salvatore SP...Seshan SV	28442280	2017
8	[THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE]. ⁶¹	Grushka NG	29975827	2017
9	Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. ⁶¹	Couvrat-Desvergnes G...Soulillou JP	26551683	2015
10	[Genotoxic stress and the pathways of thymus cell death and lymph nodes of mice in conditions of immunocomplex pathology]. ⁶¹	Grushka NG...Yanchiy RI	26040032	2015
11	Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. ⁶¹	Radic M...Marion TN	23595413	2013
12	[Vasculitis and vasculopathy]. ⁶¹	Markovic A	23193816	2012
13	[Systemic lupus erythematosus and pregnancy]. ⁶¹	Basheva S...Stoilov N	23236665	2012
14	Quantification of immune deposits in renal diseases. ⁶¹	Sarioglu S...Ellidokuz H	21606839	2011
15	Renal AA amyloidosis in a patient with hereditary complete complement C4 deficiency. ⁶¹	Helal I...Kheder A	21912034	2011
16	Effect of academic psychological stress in post-graduate students: the modulatory role of cortisol on superoxide release by neutrophils. ⁶¹	Ignacchiti MD...Mantovani B	21443430	2011
17	Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets. ⁶¹	Hamad OA...Ekdahl KN	20886107	2010
18	Risks and complications of vasectomy. ⁶¹	Adams CE...Wald M	19643235	2009
19	Molecular bases of immune complex pathology. ⁶¹	Shmagel KV...Chereshnev VA	19538120	2009
20	Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. ⁶¹	Weissmann G	19852746	2009
21	Thrombotic microangiopathy and other glomerular disorders in the HIV-infected patient. ⁶¹	Fine DM...Alpers CE	19013325	2008
22	Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. ⁶¹	Janssen BJ...Gros P	17684013	2007
23	TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells. ⁶¹	Sellitti DF...Suzuki K	17495424	2007
24	Anaphylatoxins: their role in bacterial infection and inflammation. ⁶¹	Haas PJ...van Strijp J	17873401	2007
25	Anti-C1q antibodies in hepatitis C virus infection. ⁶¹	Saadoun D...Cacoub P	16879251	2006
26	Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. ⁶¹	Boruchov AM...Young JW	16167082	2005
27	Mechanisms of immune-deposit formation and the mediation of immune renal injury. ⁶¹	Nangaku M...Couser WG	16189625	2005
28	[Investigation of the complement system in clinical practice]. ⁶¹	Fremeaux-Bacchi V...Fridman WH	15037829	2003
29	Monoclonal gammopathy: significance and possible causality in renal disease. ⁶¹	Paueksakon P...Fogo AB	12830460	2003
30	Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack. ⁶¹	Ren G...Quigg RJ	12374811	2002
31	A full complement of receptors in immune complex diseases. ⁶¹	Ravetch JV	12488423	2002
32	Endothelin levels in Henoch-Schonlein purpura. ⁵⁴	Muslu A...Sakarcan A	12432435	2002
33	Susceptibility to T cell-mediated injury in immune complex disease is linked to local activation of renin-angiotensin system: the role of NF-AT pathway. ⁶¹	Suzuki Y...Egido J	12370342	2002
34	New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. ⁶¹	Imamura T...Nakamura S	12379763	2002
35	Specific inhibition of the classical complement pathway by C1q-binding peptides. ⁶¹	Roos A...Daha MR	11739526	2001
36	Enhancement of splenic-macrophage Fcgamma receptor expression by treatment with estrogens. ⁶¹	Gomez F...Lopez-Saez JJ	11427431	2001
37	Cryoglobulinemia. ⁶¹	Dispenzieri A...Gorevic PD	10626153	1999
38	Precipitated immune complexes of IgM induce the generation of reactive oxygen species by rabbit polymorphonuclear leucocytes. ⁶¹	Lucisano YM...Mantovani B	9698825	1998
39	Risk and safety of immunotherapy. ⁶¹	Rogala B	9636805	1998
40	[Immunogerontology--aging of the immune system and its cause]. ⁶¹	Ptak W...Szczepanik M	10021884	1998
41	Glomerular lesions in HIV-infected patients: a Yale University Department of Medicine Residency Peer-Teaching Conference. ⁶¹	Wrone EM...Reilly RF	9493848	1997
42	Polymorphism of the fourth component of complement (C4) and three clinical pictures of hepatitis B virus infection in children. ⁶¹	Kacprzak-Bergman I...Halasa J	9523004	1997
43	[Lupus erythematosus systemic and persistent pulmonary salmonellosis]. ⁶¹	Godoy P...Martins GM	9011888	1996
44	Frequency of complement third component (C3) and properdin factor (BF) phenotypes in patients with various clinical manifestations of HBV infection. ⁶¹	Kacprzak-Bergman I...Halasa J	8834917	1996
45	Pharmacological effects of oral enzyme combinations. ⁶¹	Stauder G	7585874	1995
46	[Systemic enzyme therapy in diseases of the vascular system]. ⁶¹	Nouza K	8620329	1995
47	Partial C4 deficiency in two children with systemic lupus erythematosus. ⁶¹	Bakkaloglu A...Saatci U	7597765	1995
48	Physiology and pathophysiology of complement: progress and trends. ⁶¹	Morgan BP	7495498	1995
49	Expression of receptors for advanced glycosylated end-products in renal disease. ⁶¹	Abel M...Ritz E	8559486	1995
50	[Today's apheresis therapy]. ⁶¹	Kawamura A	7744369	1995

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Genes for Hypersensitivity Reaction Type Iii Disease

Genes related to Hypersensitivity Reaction Type Iii Disease (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	C5AR1	Complement C5a Receptor 1	Protein Coding	12.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	12869020 10395696
2	CD79A	CD79a Molecule	Protein Coding	9.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	12432435 8518104
3	CFHR2	Complement Factor H Related 2	Protein Coding	8.99	DISEASES inferred ¹⁵ ¹⁵
4	MIR98	MicroRNA 98	RNA Gene	7.99	DISEASES inferred ¹⁵ ¹⁵
5	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.25	DISEASES inferred ¹⁵ ¹⁵
6	C3	Complement C3	Protein Coding	7.24	DISEASES inferred ¹⁵
7	PRTN3	Proteinase 3	Protein Coding	7.15	DISEASES inferred ¹⁵
8	SERPINA3	Serpin Family A Member 3	Protein Coding	7.14	DISEASES inferred ¹⁵ ¹⁵
9	ALB	Albumin	Protein Coding	7.04	DISEASES inferred ¹⁵
10	MEFV	MEFV Innate Immuity Regulator, Pyrin	Protein Coding	6.91	DISEASES inferred ¹⁵
11	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.87	DISEASES inferred ¹⁵ ¹⁵
12	MPO	Myeloperoxidase	Protein Coding	6.81	DISEASES inferred ¹⁵
13	CRP	C-Reactive Protein	Protein Coding	6.74	DISEASES inferred ¹⁵
14	C4A	Complement C4A (Rodgers Blood Group)	Protein Coding	6.66	DISEASES inferred ¹⁵
15	C4B	Complement C4B (Chido Blood Group)	Protein Coding	6.66	DISEASES inferred ¹⁵
16	CFP	Complement Factor Properdin	Protein Coding	6.51	DISEASES inferred ¹⁵
17	FCAR	Fc Fragment Of IgA Receptor	Protein Coding	6.44	DISEASES inferred ¹⁵
18	TNF	Tumor Necrosis Factor	Protein Coding	6.43	DISEASES inferred ¹⁵
19	IL6	Interleukin 6	Protein Coding	6.37	DISEASES inferred ¹⁵
20	FCGR1A	Fc Fragment Of IgG Receptor Ia	Protein Coding	6.35	DISEASES inferred ¹⁵
21	FCGR2A	Fc Fragment Of IgG Receptor IIa	Protein Coding	6.32	DISEASES inferred ¹⁵
22	ACE	Angiotensin I Converting Enzyme	Protein Coding	6.28	DISEASES inferred ¹⁵
23	FCGR2B	Fc Fragment Of IgG Receptor IIb	Protein Coding	6.22	DISEASES inferred ¹⁵
24	CD4	CD4 Molecule	Protein Coding	6.1	DISEASES inferred ¹⁵
25	MEST	Mesoderm Specific Transcript	Protein Coding	6.06	DISEASES inferred ¹⁵

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Variations for Hypersensitivity Reaction Type Iii Disease

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Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

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Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.15	TNF SERPINA3 PRTN3 MPO MEFV IL6
2	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.71	TNF IL6 ICOSLG C4A C3
3	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁵ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.13	TNF SERPINA3 MPO IL6 CRP ALB
4	Tuberculosis ³⁶	12.1	TNF IL6 FCGR1A C3
5	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.03	TNF IL6 C4B C4A
6	Phagosome ³⁶	11.99	MPO FCGR1A FCAR C3
7	Creation of C4 and C2 activators ⁶⁵ Show member pathways Alternative complement activation ⁶⁵ Classical antibody-mediated complement activation ⁶⁵ Complement cascade ⁶⁵ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁵ Initial triggering of complement ⁶⁵ Lectin pathway of complement activation ⁶⁵ Terminal pathway of complement ⁶⁵	11.96	CRP C5AR1 C4B C4A C3
8	Complement and coagulation cascades ³⁶ ¹	11.93	CFHR2 C5AR1 C4B C4A C3
9	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.86	TNF MPO IL6 CD79A
10	Immune response Lectin induced complement pathway ²³ Show member pathways Activation of C3 and C5 ⁶⁵ Complement Activation Pathways ⁶⁶ Immune response Alternative complement pathway ²³ Immune response Classical complement pathway ²³ Regulation of Complement cascade ⁶⁵	11.83	CRP CFP C5AR1 C4B C4A C3
11	Complement Pathway ⁶³ Show member pathways Alternative Complement Pathway ⁶³ Classical Complement Pathway ⁶³ Complement Activation ¹ Lectin Induced Complement Pathway ⁶³	11.67	CFP C4B C4A C3
12	IgA-Producing B Cells in the Intestine ⁶⁴	11.55	TNF IL6 ICOSLG CCR6
13	Pertussis ³⁶	11.54	TNF IL6 C4B C4A C3
14	Legionellosis ³⁶	11.49	TNF IL6 C3
15	Staphylococcus aureus infection ³⁶	11.42	FCGR1A FCAR C5AR1 C4B C4A C3
16	amb2 Integrin signaling ¹	11.39	TNF MPO IL6
17	Overview of nanoparticle effects ¹	10.93	TNF IL6 CRP

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GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.77	TNF SERPINA3 PRTN3 MPO IL6 FCAR
2	endoplasmic reticulum lumen	GO:0005788	9.72	IL6 CFP C4A C3 ALB
3	azurophil granule lumen	GO:0035578	9.56	SERPINA3 PRTN3 MPO C3
4	blood microparticle	GO:0072562	9.55	SERPINA3 C4B C4A C3 ALB
5	extracellular space	GO:0005615	9.4	TNF SERPINA3 PRTN3 MPO MIR98 IL6

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	10.01	MEFV ICOSLG FCGR1A CFP CD79A C4B
2	innate immune response	GO:0045087	9.98	MEFV FCGR1A CRP CFP C4B C4A
3	cellular protein metabolic process	GO:0044267	9.88	IL6 C4A C3 ALB
4	neutrophil degranulation	GO:0043312	9.87	SERPINA3 PRTN3 MPO FCAR CFP C5AR1
5	complement activation, classical pathway	GO:0006958	9.84	CRP C4B C4A C3
6	negative regulation of endopeptidase activity	GO:0010951	9.83	SERPINA3 C4B C4A C3
7	defense response to Gram-positive bacterium	GO:0050830	9.78	TNF IL6 CRP C5AR1
8	complement activation	GO:0006956	9.76	CFP C4B C4A C3
9	immune response	GO:0006955	9.76	TNF IL6 FCGR1A FCAR CFP CCR6
10	humoral immune response	GO:0006959	9.72	TNF IL6 CCR6
11	acute-phase response	GO:0006953	9.69	SERPINA3 IL6 CRP
12	positive regulation of vascular endothelial growth factor production	GO:0010575	9.67	IL6 C5AR1 C3
13	neutrophil mediated immunity	GO:0002446	9.59	IL6 FCAR
14	response to peptidoglycan	GO:0032494	9.58	IL6 C5AR1
15	vascular endothelial growth factor production	GO:0010573	9.57	TNF IL6
16	opsonization	GO:0008228	9.56	CRP C4B
17	negative regulation of lipid storage	GO:0010888	9.54	TNF IL6 CRP
18	positive regulation of apoptotic cell clearance	GO:2000427	9.43	C4B C4A C3
19	regulation of complement activation	GO:0030449	9.43	CFP CFHR2 C5AR1 C4B C4A C3
20	inflammatory response	GO:0006954	9.28	TNF SERPINA3 MEFV IL6 CRP C5AR1

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	complement component C1q binding	GO:0001849	8.96	CRP C4A
2	endopeptidase inhibitor activity	GO:0004866	8.8	C4B C4A C3

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