Hypersensitivity Reaction Type Iii Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP072 MIFTS: 45	Hypersensitivity Reaction Type Iii Disease Categories: Cancer diseases, Immune diseases
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Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease ¹² ¹⁵

Immune Complex Diseases ⁵⁵ ⁴⁴ ⁷³

Immune Complex Disease ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1557

MeSH ⁴⁴ D007105

UMLS ⁷³ C0020951

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Summaries for Hypersensitivity Reaction Type Iii Disease

MalaCards based summary : Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to membranoproliferative glomerulonephritis and viral infectious disease. An important gene associated with Hypersensitivity Reaction Type Iii Disease is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. Affiliated tissues include kidney, monocytes and bone, and related phenotypes are Reduced mammosphere formation and cellular

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Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)

#	Related Disease	Score	Top Affiliating Genes
1	membranoproliferative glomerulonephritis	31.2	ALB C3 C4A CD79A ICAM1
2	viral infectious disease	29.6	IL6 TLR9 TNF
3	pustulosis palmaris et plantaris	29.3	CD79A SELE TNF
4	lupus erythematosus	29.3	C3 C4A C4B TNF
5	palindromic rheumatism	29.3	CRP MEFV TNF
6	rheumatoid arthritis	29.0	CRP ICAM1 IL6 SELE TNF
7	myeloma, multiple	29.0	ALB CRP HSP90AA1 IL6 TLR9 TNF
8	vasculitis	28.5	CRP ICAM1 MEFV MPO SELE TNF
9	glomerulonephritis	28.5	ALB C3 C4A C4B CD79A ICAM1
10	systemic lupus erythematosus	27.5	ALB C3 C4A C4B CD79A CRP
11	c1q deficiency	10.9
12	complement component c1s deficiency	10.9
13	focal dermal hypoplasia	10.3	ALB CD79A
14	parotitis	10.3	ALB CD79A
15	root caries	10.3	ALB CD79A
16	arteriolosclerosis	10.3	C3 CD79A
17	ocular toxoplasmosis	10.3	CD79A TLR9
18	abdominal tuberculosis	10.3	ALB CRP
19	pyuria	10.3	ALB CRP
20	gastrointestinal tuberculosis	10.3	ALB CRP
21	decubitus ulcer	10.3	ALB CRP
22	acute maxillary sinusitis	10.3	C3 CRP
23	acquired angioedema	10.3	C3 CRP
24	phototoxic dermatitis	10.2	C3 ICAM1
25	autoimmune glomerulonephritis	10.2	ICAM1 TLR9
26	complement factor i deficiency	10.2	C3 C4B
27	eye lymphoma	10.2	IL6 TLR9
28	epilepsy, familial temporal lobe, 2	10.2	C4A C4B
29	hymenolepiasis	10.2	ICAM1 SELE
30	mooren's ulcer	10.2	ICAM1 SELE
31	juvenile dermatitis herpetiformis	10.2	C4A C4B
32	monoclonal paraproteinemia	10.2	HSP90AA1 MPO
33	lymphocytic vasculitis	10.2	ICAM1 SELE
34	immunodeficiency due to a classical component pathway complement deficiency	10.2	C4A C4B
35	neutrophilia, hereditary	10.2	CRP IL6
36	acute cholangitis	10.2	CRP IL6
37	pasteurellosis	10.2	ALB MPO
38	cold agglutinin disease	10.2	CRP IL6
39	cryopyrin-associated periodic syndrome	10.2	CRP IL6
40	uremic pruritus	10.2	CRP IL6
41	orthostatic proteinuria	10.2	ALB C3 HSP90AA1
42	chronic monocytic leukemia	10.2	C3 MPO
43	mononeuritis multiplex	10.1	CRP MPO
44	aortitis	10.1	CRP MPO
45	mediastinitis	10.1	CRP MPO
46	pericardium disease	10.1	ALB CRP MEFV
47	iga glomerulonephritis	10.1	ALB CD79A IL6
48	cow milk allergy	10.1	CD79A TNF
49	autoinflammation, panniculitis, and dermatosis syndrome	10.1	MEFV TNF
50	systemic scleroderma	10.1	CRP SELE TLR9

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:

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Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.17	ALB C3 C4A CD79A HSP90AA1 SELE

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.13	ALB C3 CD79A HSP90AA1 ICAM1 IL6
2	homeostasis/metabolism	MP:0005376	10.1	ALB C3 C4B CD79A CRP ICAM1
3	hematopoietic system	MP:0005397	10.07	C3 C4B CD79A ICAM1 IL6 MEFV
4	cardiovascular system	MP:0005385	10.06	C3 C4B CRP ICAM1 IL6 MPO
5	immune system	MP:0005387	10.03	C3 C4B CD79A CRP HSP90AA1 ICAM1
6	digestive/alimentary	MP:0005381	9.95	ALB C3 C4B ICAM1 IL6 TLR9
7	liver/biliary system	MP:0005370	9.76	ALB C3 C4B CD79A IL6 MEFV
8	mortality/aging	MP:0010768	9.7	ALB C3 C4B HSP90AA1 ICAM1 IL6
9	renal/urinary system	MP:0005367	9.1	ALB C3 C4B CD79A IL6 TLR9

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Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

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Genetic Tests for Hypersensitivity Reaction Type Iii Disease

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Anatomical Context for Hypersensitivity Reaction Type Iii Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

⁴¹

Kidney, Monocytes, Bone, Heart, Lymph Node, Eye, Spinal Cord

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Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show all 32)

#	Title	Authors	Year
1	Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. ( 19852746 )	Weissmann G	2009
2	A full complement of receptors in immune complex diseases. ( 12488423 )	Ravetch JV	2002
3	[Therapeutic plasmapheresis in immune complex diseases]. ( 7985137 )		1994
4	Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases. ( 8098488 )	Miyata T...Maeda K	1993
5	Immune complex diseases. ( 8424984 )	Virella G	1993
6	Immune complex diseases. ( 2151123 )	Virella G	1990
7	Cationic polyelectrolytes: a new look at their possible roles as opsonins, as stimulators of respiratory burst in leukocytes, in bacteriolysis, and as modulators of immune-complex diseases (a review hypothesis). ( 2961690 )	Ginsburg I	1987
8	Complement and immune complex diseases. ( 2944500 )	Webb J...Whaley K	1986
9	Detection of complement activation in immune complex diseases: six methods compared. ( 2946496 )	Sun T...Stagias J	1986
10	Neutrophil-mediated cellular cytotoxicity triggered by immobilized aggregated IgG: an in vitro model of cell injury during immune complex diseases. ( 6096393 )	Dallegri F...Sacchetti C	1984
11	Treatment of immune complex diseases. ( 6239985 )	Kater L	1984
12	Complement-mediated inhibition of immune precipitation in patients with immune complex diseases. ( 6220848 )	Naama JK...Whaley K	1983
13	Plasma exchange and immune complex diseases: the predictability of immune complexes removal to clinical response. ( 6460383 )	Valbonesi M...Cantarella S	1982
14	Plasmapheresis in patients with leukaemia, multiple myeloma and immune complex diseases. ( 6454615 )	M?d A...Holl?n SR	1981
15	The effect of plasma exchange on the in vitro monocyte function of patients with immune complex diseases. ( 6459197 )	Steven MM...Wright R	1981
16	Factors influencing the development of immune-complex diseases. ( 6461275 )	Lamers MC	1981
17	Is autoimmunity a common denominator in immune complex diseases? ( 6101634 )	Lewis EJ...Roberts JL	1980
18	Pathopysiological aspects of immune complex diseases. Part II. Phagocytosis, exocytosis, and pathogenic depositions. ( 6447230 )	Sedlacek HH	1980
19	Plasmapheresis in patients with leukaemia, multiple myeloma and immune complex diseases. ( 6449819 )	M?d A...Holl?n SR	1980
20	Coexisting immune complex diseases in atopy. ( 6449893 )	Rebhun J	1980
21	Biochemical aspects of immune complex formation and immune complex diseases. ( 6451188 )	Steensgaard J...Johansen AS	1980
22	Pathophysiologicl aspects of immune complex diseases part i. interaction with plasma enzyme systems, cell membranes and the immune response. ( 7392533 )	Sedlacek HH	1980
23	A nephelometric study of the reaction of monoclonal rheumatoid factor with heat aggregated gamma globulin and sera from patients with immune complex diseases. ( 92379 )	Roberts-Thomson PJ...Bradley J	1979
24	Serum complement profile in human leprosy and its comparison with immune complex diseases. ( 147246 )	Saha K...Chakraborty AK	1977
25	Editorial: Are the inflammatory bowel diseases immune complex diseases? ( 128486 )	Thayer WR	1976
26	Proceedings: Models of immune complex diseases and the role of antibody affinity. ( 129487 )	Steward MW	1976
27	Canine immune complex diseases. ( 136591 )	Plechner AJ	1976
28	Immunity. II. Immune complex diseases. ( 4277523 )	McNutt DR	1974
29	Immune complex diseases. ( 4264709 )	Dixon FJ	1972
30	Virus-associated immunopathology: animal models and implications for human disease. 1. Effects of viruses on the immune system, immune-complex diseases, and antibody-mediated immunologic injury. ( 4404992 )	Allison AC...Torrigiani G	1972
31	Immune complex diseases. I. Pathological changes in the kidneys of BALB-c mice neonatally infected with Moloney leukaemogenic and murine sarcoma viruses. ( 4333814 )	Branca M...Hirsch MS	1971
32	Immune complex diseases. ( 4398333 )	Cream JJ	1971

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Genes for Hypersensitivity Reaction Type Iii Disease

Genes related to Hypersensitivity Reaction Type Iii Disease (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CD79A	CD79a Molecule	Protein Coding	20.51	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	12432435 8518104
2	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	16.52	DISEASES inferred ¹⁵
3	MEFV	MEFV, Pyrin Innate Immunity Regulator	Protein Coding	16.33	DISEASES inferred ¹⁵
4	ALB	Albumin	Protein Coding	16.14	DISEASES inferred ¹⁵
5	C3	Complement C3	Protein Coding	16.09	DISEASES inferred ¹⁵
6	TLR9	Toll Like Receptor 9	Protein Coding	16.01	DISEASES inferred ¹⁵ ¹⁵
7	C4A	Complement C4A (Rodgers Blood Group)	Protein Coding	15.67	DISEASES inferred ¹⁵
8	CRP	C-Reactive Protein	Protein Coding	15.39	DISEASES inferred ¹⁵
9	SELE	Selectin E	Protein Coding	15.19	DISEASES inferred ¹⁵
10	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	15.16	DISEASES inferred ¹⁵
11	C4B	Complement C4B (Chido Blood Group)	Protein Coding	15.14	DISEASES inferred ¹⁵
12	MPO	Myeloperoxidase	Protein Coding	15.12	DISEASES inferred ¹⁵
13	TNF	Tumor Necrosis Factor	Protein Coding	15.05	DISEASES inferred ¹⁵
14	IL6	Interleukin 6	Protein Coding	15.04	DISEASES inferred ¹⁵

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Variations for Hypersensitivity Reaction Type Iii Disease

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Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

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Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 33)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.69	C3 C4A C4B CD79A CRP HSP90AA1
2	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.92	C3 HSP90AA1 IL6 MEFV TLR9 TNF
3	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.77	C3 C4A HSP90AA1 ICAM1 IL6 TNF
4	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.71	C3 ICAM1 IL6 TLR9 TNF
5	NF-kappaB Signaling ⁴	12.46	CD79A MPO TLR9 TNF
6	Tuberculosis ³⁷	12.16	C3 IL6 TLR9 TNF
7	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.11	C4A C4B IL6 TNF
8	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.07	ALB CRP ICAM1 IL6 MPO TNF
9	Creation of C4 and C2 activators ⁶⁶ Show member pathways Alternative complement activation ⁶⁶ Classical antibody-mediated complement activation ⁶⁶ Complement cascade ⁶⁶ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁶ Initial triggering of complement ⁶⁶ Lectin pathway of complement activation ⁶⁶ Terminal pathway of complement ⁶⁶	12.05	C3 C4A C4B CRP
10	Fluid shear stress and atherosclerosis ³⁷	12.02	HSP90AA1 ICAM1 SELE TNF
11	Immune response Lectin induced complement pathway ²² Show member pathways Activation of C3 and C5 ⁶⁶ Immune response Alternative complement pathway ²² Immune response Classical complement pathway ²² Regulation of Complement cascade ⁶⁶	12	C3 C4A C4B CRP
12	Complement and coagulation cascades ¹ ³⁷	11.98	C3 C4A C4B
13	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.94	IL6 TLR9 TNF
14	Spinal Cord Injury ¹	11.91	ICAM1 IL6 TNF
15	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.91	CD79A IL6 MPO TNF
16	Interleukin-4 and 13 signaling ⁶⁶	11.89	HSP90AA1 ICAM1 IL6 TNF
17	TNF signaling pathway ³⁷	11.87	ICAM1 IL6 SELE TNF
18	Complement Pathway ⁶⁴ Show member pathways Alternative Complement Pathway ⁶⁴ Classical Complement Pathway ⁶⁴ Complement Activation ¹ Complement Activation Pathways ⁶⁷ Lectin Induced Complement Pathway ⁶⁴	11.85	C3 C4A C4B
19	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.81	ICAM1 IL6 SELE TNF
20	Rheumatoid arthritis ³⁷	11.77	ICAM1 IL6 TNF
21	Glucocorticoid receptor regulatory network ¹	11.69	HSP90AA1 ICAM1 IL6 SELE
22	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.68	IL6 TLR9 TNF
23	Legionellosis ³⁷	11.54	C3 IL6 TNF
24	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.53	ICAM1 IL6 SELE TNF
25	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.5	HSP90AA1 IL6 TNF
26	Interleukin-10 signaling ⁶⁶	11.48	ICAM1 IL6 TNF
27	Staphylococcus aureus infection ³⁷	11.45	C3 C4A C4B ICAM1
28	Pertussis ³⁷	11.43	C3 C4A C4B IL6 TNF
29	amb2 Integrin signaling ¹	11.35	ICAM1 IL6 MPO TNF
30	Malaria ³⁷	11.04	ICAM1 IL6 SELE TLR9 TNF
31	Overview of nanoparticle effects ¹	10.95	CRP IL6 TNF
32	LDL Oxidation in Atherogenesis ⁶⁴	10.84	ICAM1 MPO TNF
33	African trypanosomiasis ³⁷	10.57	ICAM1 IL6 SELE TLR9 TNF

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GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.91	ALB C3 C4A C4B HSP90AA1 ICAM1
2	extracellular region	GO:0005576	9.65	ALB C3 C4A C4B CRP HSP90AA1
3	endoplasmic reticulum lumen	GO:0005788	9.62	ALB C3 C4A IL6
4	membrane raft	GO:0045121	9.56	CD79A ICAM1 SELE TNF
5	blood microparticle	GO:0072562	9.46	ALB C3 C4A C4B
6	extracellular space	GO:0005615	9.32	ALB C3 C4A C4B CRP ICAM1

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	post-translational protein modification	GO:0043687	9.89	ALB C3 C4A IL6
2	cytokine-mediated signaling pathway	GO:0019221	9.87	HSP90AA1 ICAM1 IL6 TNF
3	immune system process	GO:0002376	9.85	C3 C4A C4B CD79A MEFV TLR9
4	cellular protein metabolic process	GO:0044267	9.8	ALB C3 C4A IL6
5	innate immune response	GO:0045087	9.8	C3 C4A C4B CRP MEFV TLR9
6	regulation of complement activation	GO:0030449	9.77	C3 C4A C4B
7	defense response to Gram-positive bacterium	GO:0050830	9.76	CRP IL6 TNF
8	complement activation	GO:0006956	9.75	C3 C4A C4B
9	complement activation, classical pathway	GO:0006958	9.73	C3 C4A C4B CRP
10	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.72	HSP90AA1 IL6 TNF
11	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.71	ICAM1 IL6 TLR9 TNF
12	positive regulation of interleukin-6 production	GO:0032755	9.65	IL6 TLR9 TNF
13	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.63	HSP90AA1 ICAM1 TNF
14	leukocyte tethering or rolling	GO:0050901	9.62	SELE TNF
15	positive regulation of glial cell proliferation	GO:0060252	9.61	IL6 TNF
16	negative regulation of growth of symbiont in host	GO:0044130	9.61	MPO TNF
17	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.56	TLR9 TNF
18	opsonization	GO:0008228	9.54	C4B CRP
19	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.52	ICAM1 TNF
20	positive regulation of neuroinflammatory response	GO:0150078	9.51	IL6 TNF
21	positive regulation of chemokine production	GO:0032722	9.43	IL6 TLR9 TNF
22	negative regulation of lipid storage	GO:0010888	9.33	CRP IL6 TNF
23	inflammatory response	GO:0006954	9.28	C3 C4A C4B CRP IL6 MEFV
24	positive regulation of apoptotic cell clearance	GO:2000427	9.13	C3 C4A C4B

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	9.26	CD79A ICAM1 SELE TLR9
2	complement component C1q binding	GO:0001849	9.16	C4A CRP
3	endopeptidase inhibitor activity	GO:0004866	8.8	C3 C4A C4B

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