MCID: HYP072
MIFTS: 44

Hypersensitivity Reaction Type Iii Disease

Categories: Immune diseases, Cancer diseases

Aliases & Classifications for Hypersensitivity Reaction Type Iii Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iii Disease:

Name: Hypersensitivity Reaction Type Iii Disease 12 15
Immune Complex Diseases 55 44 73
Immune Complex Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1557
MeSH 44 D007105
UMLS 73 C0020951

Summaries for Hypersensitivity Reaction Type Iii Disease

MalaCards based summary : Hypersensitivity Reaction Type Iii Disease, also known as immune complex diseases, is related to membranoproliferative glomerulonephritis and anemia, autoimmune hemolytic. An important gene associated with Hypersensitivity Reaction Type Iii Disease is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Prednisone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and t cells, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Hypersensitivity Reaction Type Iii Disease

Diseases in the Hypersensitivity Reaction Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Iii Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 membranoproliferative glomerulonephritis 30.2 ALB C3 C4A CD79A ICAM1
2 anemia, autoimmune hemolytic 30.2 C3 CD40LG CD79A
3 schistosomiasis 30.2 ALB CD40LG CD79A
4 aleutian mink disease 30.0 ALB CD40LG
5 pustulosis palmaris et plantaris 29.9 CD40LG CD79A SELE
6 lupus erythematosus 28.5 C3 C4A C4B CD40LG
7 vasculitis 26.7 CD40LG CD79A CRP ICAM1 MEFV MPO
8 systemic lupus erythematosus 23.0 ALB C3 C4A C4B CD40LG CD79A
9 selective igg deficiency disease 11.0 CD40LG CD79A
10 c1q nephropathy 11.0 CD40LG CD79A
11 meningovascular neurosyphilis 11.0 CD40LG CD79A
12 alpha chain disease 11.0 CD40LG CD79A
13 brill-zinsser disease 11.0 CD40LG CD79A
14 exudative glomerulonephritis 11.0 CD40LG CD79A
15 salpingo-oophoritis 11.0 CD40LG CD79A
16 early yaws 11.0 CD40LG CD79A
17 ventilation pneumonitis 11.0 CD40LG CD79A
18 chronic interstitial cystitis 11.0 CD40LG CD79A
19 axillary adenitis 11.0 CD40LG CD79A
20 cryofibrinogenemia 11.0 CD40LG CD79A
21 trichostrongyloidiasis 10.9 CD40LG CD79A
22 subacute bacterial endocarditis 10.9 CD40LG CD79A
23 immunoglobulin g deficiency 10.9 CD40LG CD79A
24 orbital granuloma 10.9 CD40LG CD79A
25 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
26 hyperglobulinemic purpura 10.9 CD40LG CD79A
27 gastroduodenitis 10.9 CD40LG CD79A
28 bacterial conjunctivitis 10.9 CD40LG CD79A
29 heavy chain disease 10.9 CD40LG CD79A
30 ophthalmia neonatorum 10.9 CD40LG CD79A
31 immunoglobulin a deficiency 1 10.9 CD40LG CD79A
32 parotid disease 10.9 CD40LG CD79A
33 cerebral arteritis 10.9 CD40LG CD79A
34 selective immunoglobulin deficiency disease 10.9 CD40LG CD79A
35 geniculate herpes zoster 10.9 CD40LG CD79A
36 ostertagiasis 10.9 ALB CD79A
37 colorado tick fever 10.9 ALB CD40LG
38 erythema elevatum diutinum 10.9 CD40LG CD79A
39 dermatitis, atopic, 3 10.9 ALB CD79A
40 sporotrichosis 10.9 CD40LG CD79A
41 fallopian tube disease 10.9 CD40LG CD79A
42 hyperimmunoglobulin syndrome 10.9 CD40LG CD79A
43 congenital syphilis 10.9 CD40LG CD79A
44 salpingitis 10.9 CD40LG CD79A
45 plasmodium malariae malaria 10.9 ALB CD40LG
46 ocular toxoplasmosis 10.9 CD40LG CD79A
47 dysgammaglobulinemia 10.9 CD40LG CD79A
48 congenital hypogammaglobulinemia 10.9 CD40LG CD79A
49 fournier gangrene 10.9 ALB CD40LG
50 chronic polyneuropathy 10.8 CD40LG CD79A

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iii Disease:



Diseases related to Hypersensitivity Reaction Type Iii Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iii Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 ALB C3 C4A CD79A HSP90AA1 SELE

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iii Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 ALB CD79A HSP90AA1 C3 ICAM1 IL6
2 homeostasis/metabolism MP:0005376 10.06 CD79A ALB CRP C3 ICAM1 C4B
3 cardiovascular system MP:0005385 10.03 CRP C3 ICAM1 C4B IL6 CD40LG
4 hematopoietic system MP:0005397 10.02 CD79A C3 ICAM1 C4B IL6 CD40LG
5 immune system MP:0005387 10 CD79A CRP C3 HSP90AA1 ICAM1 C4B
6 liver/biliary system MP:0005370 9.7 CD79A ALB C3 C4B IL6 MEFV
7 mortality/aging MP:0010768 9.65 ALB HSP90AA1 C3 ICAM1 C4B IL6
8 renal/urinary system MP:0005367 9.1 CD79A ALB C3 C4B IL6 CD40LG

Drugs & Therapeutics for Hypersensitivity Reaction Type Iii Disease

Drugs for Hypersensitivity Reaction Type Iii Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 53-03-2 5865
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 83-43-2 6741
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
4
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-24-8 5755
5
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
6
Dapsone Approved, Investigational Phase 4,Phase 2 80-08-0 2955
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
9 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
10 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Not Applicable
11 Calcineurin Inhibitors Phase 4,Not Applicable
12 glucocorticoids Phase 4,Phase 2,Not Applicable
13 Hormone Antagonists Phase 4,Phase 2,Not Applicable
14 Hormones Phase 4,Phase 2,Not Applicable
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
16 Immunosuppressive Agents Phase 4,Phase 2,Not Applicable
17 Antiemetics Phase 4,Phase 2,Not Applicable
18 Antifungal Agents Phase 4,Not Applicable
19 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
20 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
21 Autonomic Agents Phase 4,Phase 2,Not Applicable
22 Cyclosporins Phase 4,Not Applicable
23 Dermatologic Agents Phase 4,Not Applicable
24 Gastrointestinal Agents Phase 4,Phase 2,Not Applicable
25 Methylprednisolone acetate Phase 4,Phase 2,Not Applicable
26 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Not Applicable
27 Neuroprotective Agents Phase 4,Phase 2,Not Applicable
28 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
29 Prednisolone acetate Phase 4,Phase 2,Not Applicable
30 Prednisolone hemisuccinate Phase 4,Phase 2,Not Applicable
31 Prednisolone phosphate Phase 4,Phase 2,Not Applicable
32 Protective Agents Phase 4,Phase 2,Not Applicable
33 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
34 Antimalarials Phase 4,Phase 2
35 Antiparasitic Agents Phase 4,Phase 2
36 Antiprotozoal Agents Phase 4,Phase 2
37 Folic Acid Antagonists Phase 4,Phase 2
38 Vitamin B Complex Phase 4,Phase 2
39 Folate Nutraceutical Phase 4,Phase 2
40 Vitamin B9 Nutraceutical Phase 4,Phase 2
41
Cyclophosphamide Approved, Investigational Phase 2,Not Applicable 50-18-0, 6055-19-2 2907
42
Mycophenolate mofetil Approved, Investigational Phase 2,Not Applicable 128794-94-5 5281078
43
Mycophenolic acid Approved Phase 2,Not Applicable 24280-93-1 446541
44
Azathioprine Approved Phase 2 446-86-6 2265
45
Colchicine Approved Phase 2 64-86-8 6167 2833
46
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
47
Benazepril Approved, Investigational Phase 2 86541-75-5 5362124
48
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
49 Alkylating Agents Phase 2,Not Applicable
50 Antineoplastic Agents, Alkylating Phase 2,Not Applicable

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis Completed NCT03222687 Phase 4 tacrolimus;prednisone
2 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
3 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
4 Research on the Blood- Cooling - Toxin - Removing - Stasis - Dispersing Protocol Evaluation of Hench-schonlein Purpura Unknown status NCT01104428 Phase 2 Placebo;"ziying" granules
5 Absorption of Corticosteroids in Children With Juvenile Dermatomyositis Completed NCT00004357 Phase 2 Methylprednisolone;Prednisolone
6 A Comparison of the Safety, PD and PK of a Single Dose of SYN023 Administered With Licensed Rabies Vaccines Completed NCT02956746 Phase 1, Phase 2
7 Flu Vaccine Response in Patients on Biologic Therapies Recruiting NCT03277703 Phase 2
8 A Randomized Multicenter Study for Isolated Skin Vasculitis Recruiting NCT02939573 Phase 2 Colchicine;Dapsone;Azathioprine
9 The Research of Standard Diagnosis and Treatment for Severe HSP in Children Recruiting NCT02540720 Phase 2 Dexamethasone;Gamma globulin
10 The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in Children Recruiting NCT02532790 Phase 2 Prednisone;ACEI
11 The Research of Standard Diagnosis and Treatment for HSPN in Children Recruiting NCT02532777 Phase 2 Prednisone;Cyclophosphamide(CTX);Mycophenolate mofetil(MMF);Leflunomide(LEF);Angiotensin-converting enzyme inhibitor(ACEI);Methylprednisolone
12 Safety and Efficacy of Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome Terminated NCT02741362 Phase 1
13 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Unknown status NCT02811770
14 Identification of Biomarkers Predictive of Worse Prognosis in Henoch Schonlein Purpura Unknown status NCT01610830
15 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
16 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
17 Impact of Vasculitis on Employment and Income Completed NCT02476292
18 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
19 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
20 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
21 Mycophenolate Mofetil (MMF) Versus Intravenous CTX Pulses in the Treatment of Adult Severe HSPN Completed NCT00301613 Not Applicable Mycophenolate mofetil
22 Efficacy of Steroid Versus Steroid Plus Cyclophosphamide for Severe Henoch-Schoenlein Purpura Completed NCT00190229 Not Applicable Cyclophosphamide
23 VCRC Tissue Repository Recruiting NCT02967068
24 Vasculitis Pregnancy Registry Recruiting NCT02593565
25 Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura Recruiting NCT02317133
26 Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases Recruiting NCT01952275
27 Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis Enrolling by invitation NCT02878018 Qi-Ji Shen-Kang formula; Zhu-Bai formula; Yu-Shen formula;angiotensin-converting enzyme (ACE) inhibitor; adrenergic receptor binder (ARB); adrenal cortical hormone; Tripterygium wilfordii polyglycosidium; immunosuppressant
28 Pathology of Hepatitis c Nephropathy Not yet recruiting NCT03476031

Search NIH Clinical Center for Hypersensitivity Reaction Type Iii Disease

Cochrane evidence based reviews: immune complex diseases

Genetic Tests for Hypersensitivity Reaction Type Iii Disease

Anatomical Context for Hypersensitivity Reaction Type Iii Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Type Iii Disease:

41
Skin, Neutrophil, T Cells

Publications for Hypersensitivity Reaction Type Iii Disease

Articles related to Hypersensitivity Reaction Type Iii Disease:

(show all 16)
# Title Authors Year
1
Schistosoma mansoni infection: an immune complex disease presenting with polyarthritis. ( 21229360 )
2013
2
Warm autoimmune hemolytic anemia is an IgM-IgG immune complex disease. ( 16242913 )
2005
3
Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. ( 10395696 )
1999
4
Immune complex disease associated with Epstein-Barr virus infectious mononucleosis. ( 9811388 )
1998
5
Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lpr mice: a spontaneous model for human microscopic angiitis. ( 9692891 )
1998
6
Immune complex disease consistent with systemic lupus erythematosus in a patient with lysinuric protein intolerance. ( 8892019 )
1996
7
Complement deficiency and immune complex disease. ( 8153874 )
1994
8
[Therapeutic plasmapheresis in immune complex diseases]. ( 7985137 )
1994
9
Complement deficiency and the pathogenesis of autoimmune immune complex disease. ( 2140942 )
1990
10
Conceptual understanding of pustulosis palmaris et plantaris as an immune complex disease due to focal tonsillar infections. ( 6582757 )
1983
11
A case of palindromic rheumatism suggestive of immune complex disease. ( 6214631 )
1982
12
Pityriasis lichenoides, an immune complex disease? ( 6158231 )
1980
13
Mixed cryoglobulinemia-an immune complex disease often associated with hepatitis B virus infection. ( 148133 )
1977
14
Pityriasis lichenoides--an immune complex disease. ( 146510 )
1977
15
Nephropathy associated with Gardner-Diamond syndrome. Autologous erythrocyte antigen-antibody immune-complex disease. ( 140323 )
1977
16
Aleutian mink disease as a model for immune complex disease. ( 179727 )
1975

Variations for Hypersensitivity Reaction Type Iii Disease

Expression for Hypersensitivity Reaction Type Iii Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iii Disease.

Pathways for Hypersensitivity Reaction Type Iii Disease

Pathways related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 C3 C4A C4B CD40LG CD79A CRP
2
Show member pathways
12.65 C3 C4A CD40LG HSP90AA1 ICAM1 IL6
3
Show member pathways
11.99 ALB CRP ICAM1 IL6 MPO
4 11.95 CD40LG ICAM1 SELE
5
Show member pathways
11.94 C3 C4A C4B CRP
6 11.92 C3 C4A C4B
7 11.92 HSP90AA1 ICAM1 SELE
8 11.89 C3 CD40LG ICAM1
9
Show member pathways
11.88 C3 C4A C4B CRP
10 11.81 CD79A IL6 MPO
11 11.79 HSP90AA1 ICAM1 IL6
12 11.76 ICAM1 IL6 SELE
13
Show member pathways
11.74 C3 C4A C4B
14 11.7 ICAM1 IL6 SELE
15 11.62 HSP90AA1 ICAM1 IL6 SELE
16 11.5 C3 C4A C4B IL6
17 11.37 ICAM1 IL6 MPO
18
Show member pathways
11.26 CD40LG ICAM1 IL6 SELE
19 11.21 ICAM1 IL6 SELE
20 11 C3 C4A C4B ICAM1
21 10.87 CRP IL6
22 10.78 ICAM1 MPO
23 10.61 CD40LG ICAM1 IL6 SELE

GO Terms for Hypersensitivity Reaction Type Iii Disease

Cellular components related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 ALB C3 C4A C4B CRP HSP90AA1
2 extracellular region GO:0005576 9.61 ALB C3 C4A C4B CD40LG CRP
3 endoplasmic reticulum lumen GO:0005788 9.56 ALB C3 C4A IL6
4 blood microparticle GO:0072562 9.46 ALB C3 C4A C4B
5 extracellular space GO:0005615 9.32 ALB C3 C4A C4B CD40LG CRP

Biological processes related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.81 ALB C3 C4A IL6
2 immune system process GO:0002376 9.8 C3 C4A C4B CD79A MEFV
3 innate immune response GO:0045087 9.77 C3 C4A C4B CRP MEFV
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 CD40LG ICAM1 IL6
5 negative regulation of endopeptidase activity GO:0010951 9.7 C3 C4A C4B
6 regulation of complement activation GO:0030449 9.67 C3 C4A C4B
7 complement activation GO:0006956 9.65 C3 C4A C4B
8 cellular protein metabolic process GO:0044267 9.62 ALB C3 C4A IL6
9 complement activation, classical pathway GO:0006958 9.56 C3 C4A C4B CRP
10 negative regulation of lipid storage GO:0010888 9.46 CRP IL6
11 opsonization GO:0008228 9.43 C4B CRP
12 leukocyte cell-cell adhesion GO:0007159 9.33 CD40LG ICAM1 SELE
13 inflammatory response GO:0006954 9.23 C3 C4A C4B CD40LG CRP IL6
14 positive regulation of apoptotic cell clearance GO:2000427 9.13 C3 C4A C4B

Molecular functions related to Hypersensitivity Reaction Type Iii Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement component C1q binding GO:0001849 8.96 C4A CRP
2 endopeptidase inhibitor activity GO:0004866 8.8 C3 C4A C4B

Sources for Hypersensitivity Reaction Type Iii Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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