MCID: HYP073
MIFTS: 34

Hypersensitivity Reaction Type Iv Disease

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Hypersensitivity Reaction Type Iv Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iv Disease:

Name: Hypersensitivity Reaction Type Iv Disease 12 15
Immunoproliferative Disorders 44 73
Immunoproliferative Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2916
ICD10 33 C88.9 C88
MeSH 44 D007160
UMLS 73 C0021070

Summaries for Hypersensitivity Reaction Type Iv Disease

MalaCards based summary : Hypersensitivity Reaction Type Iv Disease, also known as immunoproliferative disorders, is related to heavy chain disease and autoimmune lymphoproliferative syndrome. An important gene associated with Hypersensitivity Reaction Type Iv Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Hypersensitivity Reaction Type Iv Disease

Diseases in the Hypersensitivity Reaction Disease family:

Hypersensitivity Reaction Type Iii Disease Hypersensitivity Reaction Type Iv Disease

Diseases related to Hypersensitivity Reaction Type Iv Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 heavy chain disease 32.9 CD40LG CD79A
2 autoimmune lymphoproliferative syndrome 30.3 CASP10 FAS IL2
3 sarcoidosis 1 30.1 ACE BTNL2 IFNG NOD2 TNF TNFRSF1B
4 cryoglobulinemia 11.1
5 cerebral sarcoidosis 11.0 ACE LYZ
6 selective igg deficiency disease 11.0 CD40LG CD79A
7 c1q nephropathy 11.0 CD40LG CD79A
8 cardiovascular syphilis 11.0 CD40LG SMUG1
9 meningovascular neurosyphilis 11.0 CD40LG CD79A
10 alpha chain disease 11.0 CD40LG CD79A
11 brill-zinsser disease 11.0 CD40LG CD79A
12 exudative glomerulonephritis 11.0 CD40LG CD79A
13 cork-handlers' disease 11.0 CD40LG CD79A
14 salpingo-oophoritis 11.0 CD40LG CD79A
15 early yaws 11.0 CD40LG CD79A
16 ventilation pneumonitis 11.0 CD40LG CD79A
17 chronic interstitial cystitis 11.0 CD40LG CD79A
18 axillary adenitis 10.9 CD40LG CD79A
19 cryofibrinogenemia 10.9 CD40LG CD79A
20 ulcerative blepharitis 10.9 CD79A LYZ
21 trichostrongyloidiasis 10.9 CD40LG CD79A
22 subacute bacterial endocarditis 10.9 CD40LG CD79A
23 heterophyiasis 10.9 CD40LG CD79A
24 immunoglobulin g deficiency 10.9 CD40LG CD79A
25 orbital granuloma 10.9 CD40LG CD79A
26 anthracosilicosis 10.9 ACE SMUG1
27 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
28 subacute cutaneous lupus erythematosus 10.9 ACE TNF
29 hyperglobulinemic purpura 10.8 CD40LG CD79A
30 gastroduodenitis 10.8 CD40LG CD79A
31 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A MYOM2
32 bacterial conjunctivitis 10.8 CD40LG CD79A
33 chronic polyneuropathy 10.8 CD40LG CD79A MYOM2
34 autoimmune disease of urogenital tract 10.8 CD40LG CD79A TLR9
35 plasma protein metabolism disease 10.8 CD40LG CD79A MYOM2
36 neuroretinitis 10.8 ACE CD40LG LYZ
37 rectum squamous cell carcinoma 10.8 SMUG1 TNFRSF1B
38 plasma cell neoplasm 10.8 CD40LG CD79A MYOM2
39 meningoencephalitis 10.8 CD40LG CD79A TLR9
40 b cell deficiency 10.8 CD40LG CD79A TLR9
41 ophthalmia neonatorum 10.8 CD40LG CD79A
42 endocardium disease 10.8 CD40LG CD79A SMUG1
43 lung lymphoma 10.7 CD40LG CD79A SMUG1
44 diffuse glomerulonephritis 10.7 CD40LG CD79A LYZ
45 acute proliferative glomerulonephritis 10.7 CD40LG CD79A LYZ
46 rheumatic heart disease 10.7 ACE MYOM2 TNF
47 pyelitis 10.7 CD40LG CD79A LYZ
48 pulmonary hemosiderosis 10.7 CD40LG CD79A LYZ
49 jejunoileitis 10.7 CD40LG CD79A TNF
50 immunoglobulin a deficiency 1 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iv Disease:



Diseases related to Hypersensitivity Reaction Type Iv Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iv Disease

GenomeRNAi Phenotypes related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CD40LG FAS IL2 NOD2 TNF TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CD40LG FAS IL2 NOD2 TNF TNFRSF1B

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iv Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 IFNG CD40LG IL1RN CD79A IL2 FAS
2 hematopoietic system MP:0005397 10.18 IFNG CD40LG IL1RN CD79A IL2 FAS
3 homeostasis/metabolism MP:0005376 10.18 ACE IFNG CD40LG IL1RN CD79A IL2
4 cardiovascular system MP:0005385 10.13 ACE IFNG CD40LG IL1RN FAS TNF
5 immune system MP:0005387 10.1 IFNG CD40LG IL1RN CD79A IL2 FAS
6 digestive/alimentary MP:0005381 10.03 IFNG IL2 FAS LYZ NOD2 TNFRSF1B
7 mortality/aging MP:0010768 9.93 ACE IFNG CD40LG IL1RN IL2 FAS
8 liver/biliary system MP:0005370 9.86 ACE IFNG CD79A IL2 FAS TNFRSF1B
9 neoplasm MP:0002006 9.61 IFNG CD79A IL2 FAS ACE TNFRSF1B
10 renal/urinary system MP:0005367 9.23 IFNG CD40LG CD79A FAS ACE TNFRSF1B

Drugs & Therapeutics for Hypersensitivity Reaction Type Iv Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Type Iv Disease

Cochrane evidence based reviews: immunoproliferative disorders

Genetic Tests for Hypersensitivity Reaction Type Iv Disease

Anatomical Context for Hypersensitivity Reaction Type Iv Disease

Publications for Hypersensitivity Reaction Type Iv Disease

Articles related to Hypersensitivity Reaction Type Iv Disease:

# Title Authors Year
1
Alpha-chain disease: an immunoproliferative disease of the secretory immune system. ( 6408973 )
1983

Variations for Hypersensitivity Reaction Type Iv Disease

Expression for Hypersensitivity Reaction Type Iv Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iv Disease.

Pathways for Hypersensitivity Reaction Type Iv Disease

Pathways related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 BTNL2 CASP10 CD40LG CD79A IFNG IL1RN
2
Show member pathways
13.3 CD40LG IFNG IL1RN IL2 NOD2 TNF
3
Show member pathways
12.91 ACE FAS IFNG IL2 NOD2 TLR9
4
Show member pathways
12.87 CASP10 CD40LG CD79A FAS TNF TNFRSF1B
5
Show member pathways
12.78 CD40LG FAS IFNG IL2 TNF TNFRSF1B
6
Show member pathways
12.74 CD79A IFNG IL2 TLR9 TNF
7
Show member pathways
12.73 FAS IFNG IL2 TLR9 TNF
8
Show member pathways
12.64 CD40LG IL2 TLR9 TNF TNFRSF1B
9
Show member pathways
12.57 CD40LG FAS IFNG TNF TNFRSF1B
10
Show member pathways
12.43 CASP10 FAS TNF TNFRSF1B
11
Show member pathways
12.38 IFNG IL2 NOD2 TNF
12
Show member pathways
12.36 CASP10 CD40LG TLR9 TNF TNFRSF1B
13
Show member pathways
12.33 CD40LG FAS IFNG IL2 TNF
14
Show member pathways
12.27 CASP10 FAS TNF TNFRSF1B
15
Show member pathways
12.19 IFNG IL2 TLR9 TNF
16 12.18 CD40LG FAS TNF TNFRSF1B
17
Show member pathways
12.11 FAS IFNG TLR9 TNF
18 12.11 CASP10 IFNG NOD2 TLR9 TNF
19 11.91 CD79A IFNG IL2 TNF
20 11.79 CD40LG CD79A FAS IFNG IL1RN IL2
21 11.73 IFNG IL2 TNF
22 11.69 CASP10 FAS NOD2 TNF TNFRSF1B
23
Show member pathways
11.68 CD40LG TNF TNFRSF1B
24
Show member pathways
11.68 CD40LG IFNG IL2 TNF
25 11.65 IFNG IL2 TLR9 TNF
26
Show member pathways
11.59 IFNG IL2 TNF
27
Show member pathways
11.5 CD40LG IFNG IL2 TNF
28
Show member pathways
11.48 IFNG TNF TNFRSF1B
29 11.46 IL1RN TNF TNFRSF1B
30 11.44 IFNG IL2 TNF
31 11.38 FAS IFNG IL2 TNF
32 11.31 CD40LG IFNG TLR9 TNF
33 11.19 IFNG IL2 TNF
34 11 FAS IFNG TLR9 TNF
35 10.78 CD40LG IFNG IL2 TNFRSF1B

GO Terms for Hypersensitivity Reaction Type Iv Disease

Cellular components related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 ACE CD40LG IFNG IL1RN IL2 LYZ
2 extracellular region GO:0005576 9.65 ACE CD40LG FAS IFNG IL1RN IL2
3 membrane raft GO:0045121 9.56 CD79A FAS TNF TNFRSF1B
4 CD95 death-inducing signaling complex GO:0031265 9.16 CASP10 FAS
5 external side of plasma membrane GO:0009897 9.02 ACE BTNL2 CD40LG CD79A TNF

Biological processes related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CD40LG IFNG IL1RN IL2 TNF
2 cell surface receptor signaling pathway GO:0007166 9.93 CASP10 CD79A IFNG TNFRSF1B
3 defense response to bacterium GO:0042742 9.9 LYZ NOD2 TLR9 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.86 CASP10 NOD2 TLR9 TNF
5 positive regulation of protein phosphorylation GO:0001934 9.83 FAS IFNG IL2 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 CD40LG NOD2 TLR9 TNF
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 CD40LG FAS TNF TNFRSF1B
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.79 CASP10 FAS TNF
9 positive regulation of JNK cascade GO:0046330 9.78 NOD2 TLR9 TNF
10 positive regulation of T cell proliferation GO:0042102 9.76 BTNL2 CD40LG IL2
11 positive regulation of interleukin-6 production GO:0032755 9.74 NOD2 TLR9 TNF
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.72 NOD2 TLR9 TNF
13 immune response GO:0006955 9.7 CD40LG FAS IFNG IL1RN IL2 TNF
14 positive regulation of interleukin-8 production GO:0032757 9.63 NOD2 TLR9 TNF
15 positive regulation of interleukin-17 production GO:0032740 9.62 IL2 NOD2
16 apoptotic signaling pathway GO:0097190 9.62 CASP10 FAS TNF TNFRSF1B
17 maintenance of gastrointestinal epithelium GO:0030277 9.61 NOD2 TLR9
18 necroptotic signaling pathway GO:0097527 9.58 FAS TNF
19 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG IFNG TLR9
20 regulation of immunoglobulin secretion GO:0051023 9.54 CD40LG TNF
21 positive regulation of interleukin-10 production GO:0032733 9.54 CD40LG NOD2 TLR9
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG TNF TNFRSF1B
25 extrinsic apoptotic signaling pathway GO:0097191 9.26 FAS IFNG TNF TNFRSF1B
26 inflammatory response GO:0006954 9.23 CD40LG FAS IL1RN LYZ NOD2 TLR9

Molecular functions related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CD40LG IFNG IL1RN IL2 TNF
2 peptidyl-dipeptidase activity GO:0008241 8.96 ACE ENSG00000264813

Sources for Hypersensitivity Reaction Type Iv Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....