MCID: HYP073
MIFTS: 45

Hypersensitivity Reaction Type Iv Disease

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Hypersensitivity Reaction Type Iv Disease

MalaCards integrated aliases for Hypersensitivity Reaction Type Iv Disease:

Name: Hypersensitivity Reaction Type Iv Disease 12 15
Immunoproliferative Disorders 44 73
Immunoproliferative Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2916
ICD10 33 C88.9 C88
MeSH 44 D007160
SNOMED-CT 68 86295000
UMLS 73 C0021070

Summaries for Hypersensitivity Reaction Type Iv Disease

MalaCards based summary : Hypersensitivity Reaction Type Iv Disease, also known as immunoproliferative disorders, is related to sarcoidosis 1 and autoimmune lymphoproliferative syndrome. An important gene associated with Hypersensitivity Reaction Type Iv Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include b cells, t cells and bone, and related phenotypes are digestive/alimentary and hematopoietic system

Related Diseases for Hypersensitivity Reaction Type Iv Disease

Diseases in the Hypersensitivity Reaction Type Iv Disease family:

Hypersensitivity Reaction Type Iii Disease

Diseases related to Hypersensitivity Reaction Type Iv Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 31.6 ACE BTNL2 IFNG IL2 NOD2 TNF
2 autoimmune lymphoproliferative syndrome 31.5 ARFGAP1 CASP10 FAS IL2 MAS1L
3 heavy chain disease 11.3
4 cryoglobulinemia 11.3
5 lymphoid interstitial pneumonia 11.2
6 cerebral sarcoidosis 10.3 ACE LYZ
7 aortitis 10.3 MRAP SMUG1
8 chronic gonococcal salpingitis 10.3 TNF TNFRSF1B
9 pouchitis 10.3 IL1RN NOD2
10 rectum squamous cell carcinoma 10.3 SMUG1 TNFRSF1B
11 subacute cutaneous lupus erythematosus 10.3 ACE TNF
12 anthracosilicosis 10.3 ACE SMUG1
13 extrinsic cardiomyopathy 10.3 ACE TLR9 TNF
14 oral tuberculosis 10.2 IL2 TNF
15 inflammatory bowel disease 20 10.2 MRAP NOD2
16 rheumatic heart disease 10.2 ACE MYOM2 TNF
17 splenic tuberculosis 10.2 IL2 SMUG1
18 streptococcal meningitis 10.2 MYOM2 NOD2 TNF
19 loeffler syndrome 10.2 ACE ENSG00000264813
20 skin sarcoidosis 10.2 ACE TNF TNFRSF1B
21 granulomatous myositis 10.2 LYZ SMUG1 TNFRSF1B
22 rheumatoid lung disease 10.2 SMUG1 TNF TNFRSF1B
23 systemic onset juvenile idiopathic arthritis 10.2 IL1RN TNF
24 female reproductive system disease 10.2 SMUG1 TLR9 TNF
25 reproductive system disease 10.2 SMUG1 TLR9 TNF
26 cogan syndrome 10.2 SMUG1 TNF TNFRSF1B
27 periodic fever, familial, autosomal dominant 10.2 LYZ TNF TNFRSF1B
28 osteosclerotic myeloma 10.2 IL1RN MYOM2 TNF
29 streptococcal toxic-shock syndrome 10.2 IL2 MYOM2 TNF
30 autoimmune atherosclerosis 10.2 ACE ENSG00000264813
31 staphylococcal toxic shock syndrome 10.2 IFNG TNF
32 microscopic colitis 10.2 IL2 LYZ TNF
33 rheumatic fever 10.2 IL2 MYOM2 TNF
34 guillain-barre syndrome 10.2 FAS TNF TNFRSF1B
35 cerebral lymphoma 10.2 SMUG1 TLR9
36 cardiac sarcoidosis 10.2 IFNG SMUG1 TNF
37 chondromalacia 10.2 IL1RN SMUG1 TNFRSF1B
38 lichen disease 10.2 IFNG TLR9 TNF
39 posterior scleritis 10.2 MRAP TNF
40 parasitic helminthiasis infectious disease 10.2 IL2 TLR9 TNF
41 lymphoproliferative syndrome 10.2 CASP10 FAS IL2
42 tuberculous peritonitis 10.2 IFNG SMUG1 TNF
43 autoimmune disease of musculoskeletal system 10.2 IL2 TLR9 TNF
44 opportunistic mycosis 10.2 IFNG TLR9 TNF
45 panuveitis 10.2 MRAP TNF TNFRSF1B
46 autoimmune myocarditis 10.2 IFNG TNF
47 palindromic rheumatism 10.2 MRAP TNF TNFRSF1B
48 gastrointestinal system cancer 10.2 SMUG1 TLR9 TNF
49 waldenstrom macroglobulinemia 10.1
50 alpha-heavy chain disease 10.1

Graphical network of the top 20 diseases related to Hypersensitivity Reaction Type Iv Disease:



Diseases related to Hypersensitivity Reaction Type Iv Disease

Symptoms & Phenotypes for Hypersensitivity Reaction Type Iv Disease

MGI Mouse Phenotypes related to Hypersensitivity Reaction Type Iv Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 FAS IFNG IL2 LYZ NOD2 TLR9
2 hematopoietic system MP:0005397 9.85 ACE FAS IFNG IL1RN IL2 LYZ
3 liver/biliary system MP:0005370 9.5 ACE FAS IFNG IL2 LYZ TNF
4 neoplasm MP:0002006 9.23 ACE FAS IFNG IL2 LYZ SMUG1

Drugs & Therapeutics for Hypersensitivity Reaction Type Iv Disease

Search Clinical Trials , NIH Clinical Center for Hypersensitivity Reaction Type Iv Disease

Cochrane evidence based reviews: immunoproliferative disorders

Genetic Tests for Hypersensitivity Reaction Type Iv Disease

Anatomical Context for Hypersensitivity Reaction Type Iv Disease

MalaCards organs/tissues related to Hypersensitivity Reaction Type Iv Disease:

41
B Cells, T Cells, Bone, Myeloid, Bone Marrow, Lung, Heart

Publications for Hypersensitivity Reaction Type Iv Disease

Articles related to Hypersensitivity Reaction Type Iv Disease:

(show all 11)
# Title Authors Year
1
CD200 expression in plasma cells of nonmyeloma immunoproliferative disorders: clinicopathologic features and comparison with plasma cell myeloma. ( 23161721 )
2012
2
Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients. ( 14652716 )
2004
3
Effect of alpha IFN on unaggressive immunoproliferative disorders. ( 7758989 )
1995
4
Atypical immunoproliferative disorders: when of age? ( 8506619 )
1993
5
Structurally abnormal immunoglobulins in human immunoproliferative disorders. ( 1571535 )
1992
6
Immunoproliferative disorders: detection, prevention, and therapeutics. ( 2508454 )
1989
7
Study of the natural history of immunoblastic lymphadenopathy and atypical immunoproliferative disorders. ( 6667410 )
1983
8
Development of acute erythroleukemia in B-cell immunoproliferative disorders after prolonged therapy with alkylating drugs. ( 4216270 )
1974
9
Surface IgD in immunoproliferative disorders. ( 4218365 )
1974
10
Lymphocyte transformation in immunoproliferative disorders. ( 4114813 )
1972
11
M-components in immunoproliferative disorders. Electrophoretic and immunologic analysis of 200 cases. ( 4964131 )
1967

Variations for Hypersensitivity Reaction Type Iv Disease

Expression for Hypersensitivity Reaction Type Iv Disease

Search GEO for disease gene expression data for Hypersensitivity Reaction Type Iv Disease.

Pathways for Hypersensitivity Reaction Type Iv Disease

Pathways related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 BTNL2 CASP10 IFNA1 IFNG IL1RN IL2
2
Show member pathways
13.29 IFNA1 IFNG IL1RN IL2 NOD2 TNF
3
Show member pathways
12.78 ACE FAS IFNA1 IFNG IL2 NOD2
4
Show member pathways
12.75 FAS IFNA1 IFNG IL2 TNF TNFRSF1B
5
Show member pathways
12.62 FAS IFNA1 IFNG IL2 TLR9 TNF
6
Show member pathways
12.54 CASP10 FAS TLR9 TNF TNFRSF1B
7
Show member pathways
12.41 CASP10 FAS TNF TNFRSF1B
8
Show member pathways
12.38 FAS IFNA1 IFNG IL2 TNF
9
Show member pathways
12.35 FAS IFNG IL2 TNF
10
Show member pathways
12.25 CASP10 FAS TNF TNFRSF1B
11
Show member pathways
12.13 FAS IFNA1 IFNG TNF
12
Show member pathways
12.08 FAS IFNG TLR9 TNF
13
Show member pathways
11.94 IFNG IL2 TLR9 TNF
14 11.74 FAS IFNA1 IFNG IL1RN IL2 TLR9
15 11.71 IFNG IL2 TNF
16 11.7 CASP10 FAS NOD2 TNF TNFRSF1B
17 11.69 CASP10 IFNA1 IFNG NOD2 TLR9 TNF
18
Show member pathways
11.68 IFNG IL2 TNF
19 11.6 IFNG IL2 TLR9 TNF
20
Show member pathways
11.58 IFNG IL2 TNF
21
Show member pathways
11.56 IFNG IL2 TNF
22 11.56 IFNG IL1RN IL2 TNF
23
Show member pathways
11.46 IFNG TNF TNFRSF1B
24 11.44 IL1RN TNF TNFRSF1B
25 11.43 IFNG TLR9 TNF
26 11.4 IFNG IL2 TNF
27 11.38 FAS IFNG IL2 TNF
28 11.19 IFNG IL2 TNFRSF1B
29 11.12 IFNG IL2 TNF
30 11 FAS IFNG TLR9 TNF

GO Terms for Hypersensitivity Reaction Type Iv Disease

Cellular components related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 ACE ENSG00000264813 IFNA1 IFNG IL1RN IL2
2 extracellular region GO:0005576 9.32 ACE FAS IFNA1 IFNG IL1RN IL2
3 CD95 death-inducing signaling complex GO:0031265 8.96 CASP10 FAS

Biological processes related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 IFNA1 IFNG IL1RN IL2 TNF
2 inflammatory response GO:0006954 9.93 IL1RN LYZ TLR9 TNF TNFRSF1B
3 defense response to bacterium GO:0042742 9.92 LYZ NOD2 TLR9 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.87 FAS IFNG IL2 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.85 IFNA1 IL1RN IL2 TNF TNFRSF1B
6 cellular response to lipopolysaccharide GO:0071222 9.83 IL1RN NOD2 TNF TNFRSF1B
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 CASP10 FAS TNF
8 positive regulation of inflammatory response GO:0050729 9.79 IL2 TLR9 TNF
9 apoptotic signaling pathway GO:0097190 9.76 CASP10 FAS TNF
10 humoral immune response GO:0006959 9.75 IFNA1 IFNG TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.72 NOD2 TLR9 TNF
12 positive regulation of JUN kinase activity GO:0043507 9.67 IL1RN TLR9 TNF
13 positive regulation of JNK cascade GO:0046330 9.67 IL1RN NOD2 TLR9 TNF
14 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.65 CASP10 IL1RN NOD2 TLR9 TNF
15 maintenance of gastrointestinal epithelium GO:0030277 9.64 NOD2 TLR9
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 NOD2 TLR9
17 positive regulation of interleukin-17 production GO:0032740 9.63 IL2 NOD2
18 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 TLR9 TNF
19 positive regulation of interleukin-8 production GO:0032757 9.61 NOD2 TLR9 TNF
20 positive regulation of systemic arterial blood pressure GO:0003084 9.6 ACE ENSG00000264813
21 necroptotic signaling pathway GO:0097527 9.56 FAS TNF
22 chronic inflammatory response to antigenic stimulus GO:0002439 9.51 IL1RN TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.5 IFNG TNF TNFRSF1B
24 immune response GO:0006955 9.5 FAS IFNG IL1RN IL2 TLR9 TNF
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
26 positive regulation of interleukin-6 production GO:0032755 9.46 IL1RN NOD2 TLR9 TNF
27 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
28 extrinsic apoptotic signaling pathway GO:0097191 8.92 FAS IFNG TNF TNFRSF1B

Molecular functions related to Hypersensitivity Reaction Type Iv Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dipeptidyl-peptidase activity GO:0008239 9.32 ACE ENSG00000264813
2 interleukin-1 receptor binding GO:0005149 9.26 IL1RN TLR9
3 exopeptidase activity GO:0008238 9.16 ACE ENSG00000264813
4 cytokine activity GO:0005125 9.02 IFNA1 IFNG IL1RN IL2 TNF
5 peptidyl-dipeptidase activity GO:0008241 8.96 ACE ENSG00000264813

Sources for Hypersensitivity Reaction Type Iv Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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