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MCID: HYP074
MIFTS: 51

Hypersensitivity Vasculitis

Categories: Rare diseases, Cardiovascular diseases, Bone diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hypersensitivity Vasculitis

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MalaCards integrated aliases for Hypersensitivity Vasculitis:

Name: Hypersensitivity Vasculitis 12 53 15
Cutaneous Small Vessel Vasculitis 53 59 73
Vasculitis, Leukocytoclastic, Cutaneous 44 73
Cutaneous Leukocytoclastic Vasculitis 53 59
Cutaneous Leukocytoclastic Angiitis 53 59
Hypersensitivity Angiitis 53 59
Cutaneous Hypersensitivity Vasculitis 59
Drug Induced Cutaneous Vasculitis 73
Vasculitis Hypersensitivity 76
Leukocytoclastic Vasculitis 73
Leukocytoclastic Angiitis 53

Characteristics:

Orphanet epidemiological data:

59
cutaneous leukocytoclastic angiitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare circulatory system diseases
Rare systemic and rhumatological diseases


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Summaries for Hypersensitivity Vasculitis

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NIH Rare Diseases : 53 Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance that leads to inflammation and damage to blood vessels of the skin. Signs and symptoms may include purple-colored spots and patches on the skin; skin lesions on the legs, buttocks, or trunk; blisters on the skin; hives (urticaria); and/or open sores with dead tissue (necrotic ulcers). This condition is caused by an allergic reaction to a drug or other foreign substance. This condition usually goes away over time; but on occasion, people can have repeated episodes.

MalaCards based summary : Hypersensitivity Vasculitis, also known as cutaneous small vessel vasculitis, is related to purpura and vasculitis. An important gene associated with Hypersensitivity Vasculitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Dapsone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related phenotypes are cutis marmorata and purpura

Wikipedia : 76 Cutaneous small-vessel vasculitis, also known as hypersensitivity vasculitis, cutaneous leukocytoclastic... more...

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Related Diseases for Hypersensitivity Vasculitis

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Diseases related to Hypersensitivity Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 purpura 30.7 CD40LG CD79A CRP
2 vasculitis 30.1 CD40LG CD79A CRP MEFV MPO
3 mononeuritis multiplex 29.9 CD40LG CRP MPO
4 churg-strauss syndrome 29.5 CD40LG MPO
5 lupus erythematosus 29.3 C3 C4A CD40LG
6 systemic lupus erythematosus 27.7 C3 C4A CD40LG CD79A CRP MPO
7 allergic cutaneous vasculitis 11.0
8 intestinal tuberculosis 10.9 CD79A CRP
9 selective igg deficiency disease 10.8 CD40LG CD79A
10 c1q nephropathy 10.8 CD40LG CD79A
11 meningovascular neurosyphilis 10.8 CD40LG CD79A
12 alpha chain disease 10.8 CD40LG CD79A
13 brill-zinsser disease 10.8 CD40LG CD79A
14 exudative glomerulonephritis 10.8 CD40LG CD79A
15 cork-handlers' disease 10.8 CD40LG CD79A
16 acalculous cholecystitis 10.8 CD40LG CRP
17 salpingo-oophoritis 10.8 CD40LG CD79A
18 early yaws 10.8 CD40LG CD79A
19 ventilation pneumonitis 10.8 CD40LG CD79A
20 chronic interstitial cystitis 10.8 CD40LG CD79A
21 axillary adenitis 10.8 CD40LG CD79A
22 cryofibrinogenemia 10.8 CD40LG CD79A
23 trichostrongyloidiasis 10.8 CD40LG CD79A
24 subacute bacterial endocarditis 10.8 CD40LG CD79A
25 heterophyiasis 10.8 CD40LG CD79A
26 immunoglobulin g deficiency 10.8 CD40LG CD79A
27 orbital granuloma 10.8 CD40LG CD79A
28 transient hypogammaglobulinemia of infancy 10.8 CD40LG CD79A
29 relapsing fever 10.8 CRP MEFV
30 hyperglobulinemic purpura 10.8 CD40LG CD79A
31 gastroduodenitis 10.8 CD40LG CD79A
32 bacterial conjunctivitis 10.8 CD40LG CD79A
33 heavy chain disease 10.8 CD40LG CD79A
34 ophthalmia neonatorum 10.8 CD40LG CD79A
35 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
36 parotid disease 10.8 CD40LG CD79A
37 cerebral arteritis 10.8 CD40LG CD79A
38 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
39 amyloidosis aa 10.8 CRP MEFV
40 geniculate herpes zoster 10.8 CD40LG CD79A
41 japanese spotted fever 10.8 CD40LG CRP
42 erythema elevatum diutinum 10.8 CD40LG CD79A
43 sporotrichosis 10.8 CD40LG CD79A
44 fallopian tube disease 10.8 CD40LG CD79A
45 hyperimmunoglobulin syndrome 10.8 CD40LG CD79A
46 congenital syphilis 10.8 CD40LG CD79A
47 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A
48 acquired angioedema 10.8 C3 CRP
49 salpingitis 10.8 CD40LG CD79A
50 ocular toxoplasmosis 10.7 CD40LG CD79A

Comorbidity relations with Hypersensitivity Vasculitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Postinflammatory Pulmonary Fibrosis
Rheumatoid Arthritis Systemic Lupus Erythematosus

Graphical network of the top 20 diseases related to Hypersensitivity Vasculitis:



Diseases related to Hypersensitivity Vasculitis
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Symptoms & Phenotypes for Hypersensitivity Vasculitis

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Human phenotypes related to Hypersensitivity Vasculitis:

59 32 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cutis marmorata 59 32 hallmark (90%) Very frequent (99-80%) HP:0000965
2 purpura 59 32 hallmark (90%) Very frequent (99-80%) HP:0000979
3 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
4 urticaria 59 32 hallmark (90%) Very frequent (99-80%) HP:0001025
5 subcutaneous nodule 59 32 occasional (7.5%) Occasional (29-5%) HP:0001482
6 recurrent skin infections 59 32 hallmark (90%) Very frequent (99-80%) HP:0001581
7 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
8 vasculitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002633
9 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
10 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
11 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
12 gangrene 59 32 hallmark (90%) Very frequent (99-80%) HP:0100758
13 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
14 abnormality of the oral cavity 59 Occasional (29-5%)
15 abnormal oral cavity morphology 32 occasional (7.5%) HP:0000163

MGI Mouse Phenotypes related to Hypersensitivity Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 C1GALT1 C3 CD40LG CD79A CRP HSP90AA1
Sources

Drugs & Therapeutics for Hypersensitivity Vasculitis

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Drugs for Hypersensitivity Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Anti-Infective Agents Phase 4,Not Applicable
5 Folic Acid Antagonists Phase 4
6 Anti-Bacterial Agents Phase 4
7 Vitamin B Complex Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 Antimalarials Phase 4
11 Folate Nutraceutical Phase 4
12 Vitamin B9 Nutraceutical Phase 4
13 Omega 3 Fatty Acid Nutraceutical Phase 4
14 Antibodies Phase 1, Phase 2
15 Immunoglobulins Phase 1, Phase 2
16 Antibodies, Monoclonal Phase 1, Phase 2
17
Lenograstim Approved, Investigational Not Applicable 135968-09-1
18
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
19
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
20
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
21
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
22
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
23 Prednisolone acetate Not Applicable
24 Alkylating Agents Not Applicable
25 glucocorticoids Not Applicable
26 Methylprednisolone acetate Not Applicable
27 Methylprednisolone Hemisuccinate Not Applicable
28 Gastrointestinal Agents Not Applicable
29 Neuroprotective Agents Not Applicable
30 Cyclosporins Not Applicable
31 Hormone Antagonists Not Applicable
32 Dermatologic Agents Not Applicable
33 Hormones Not Applicable
34 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
35 Peripheral Nervous System Agents Not Applicable
36 Immunoglobulin A
37 Immunosuppressive Agents Not Applicable
38 Prednisolone hemisuccinate Not Applicable
39 Prednisolone phosphate Not Applicable
40 Antiemetics Not Applicable
41 Antifungal Agents Not Applicable
42 Antigen-Antibody Complex
43 Protective Agents Not Applicable
44 Anti-Inflammatory Agents Not Applicable
45 Antilymphocyte Serum Not Applicable
46 Antirheumatic Agents Not Applicable
47 Autonomic Agents Not Applicable
48 Calcineurin Inhibitors Not Applicable
49 Antineoplastic Agents, Alkylating Not Applicable
50 Antineoplastic Agents, Hormonal Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
2 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
3 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
4 IgA-positive Versus IgA-negative Immune Complex Vasculitis Unknown status NCT01815190
5 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
6 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129

Search NIH Clinical Center for Hypersensitivity Vasculitis

Cochrane evidence based reviews: vasculitis, leukocytoclastic, cutaneous

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Genetic Tests for Hypersensitivity Vasculitis

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Anatomical Context for Hypersensitivity Vasculitis

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MalaCards organs/tissues related to Hypersensitivity Vasculitis:

41
Skin, Bone, Liver, Thyroid
Sources

Publications for Hypersensitivity Vasculitis

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Articles related to Hypersensitivity Vasculitis:

(show top 50) (show all 73)
# Title Authors Year
1
Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis. ( 29441165 )
2018
2
Leukocytoclastic Vasculitis (Hypersensitivity Vasculitis) ( 29489227 )
2018
3
Revisiting clinical differences between hypersensitivity vasculitis and Henoch-SchAPnlein purpura in adults from a defined population. ( 24528895 )
2014
4
Carbimazole-associated hypersensitivity vasculitis in a cat. ( 24255992 )
2013
5
Paracetamol-induced hypersensitivity vasculitis in a 10-year-old child. ( 24379075 )
2013
6
Cutaneous small vessel vasculitis accompanied by pustulosis palmaris et plantaris. ( 22548039 )
2012
7
Ink sick: tattoo ink hypersensitivity vasculitis. ( 21035978 )
2011
8
Hypersensitivity vasculitis associated with leuprolide (Lupron). ( 20470239 )
2010
9
Hepatitis C- and human immunodeficiency virus-induced hypersensitivity vasculitis: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. ( 19921341 )
2010
10
Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor. ( 20204065 )
2009
11
A stinging rash of indeterminate origin. Idiopathic hypersensitivity vasculitis. ( 19235501 )
2009
12
A case of hypersensitivity vasculitis after vinorelbine injection in a patient with metastatic breast cancer. ( 17419038 )
2007
13
Immunological diagnosis of cutaneous-pulmonary hypersensitivity vasculitis. ( 17332983 )
2007
14
Prevalence of human parvovirus B19 component NS1 gene in patients with Henoch-Schonlein purpura and hypersensitivity vasculitis. ( 15888184 )
2005
15
Renal hypersensitivity vasculitis associated with dapsone. ( 16183407 )
2005
16
Hypersensitivity vasculitis with leukocytoclastic vasculitis secondary to infliximab. ( 12702983 )
2003
17
Hypersensitivity vasculitis induced by cefoperazone/sulbactam. ( 12556245 )
2003
18
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. ( 12700924 )
2003
19
Hypersensitivity vasculitis and cytokines. ( 12426663 )
2002
20
Hypersensitivity vasculitis induced by cefprozil. ( 17159422 )
2002
21
Hypersensitivity vasculitis in adults: a benign disease usually limited to skin. ( 11247332 )
2001
22
Are Henoch-SchAPnlein purpura and hypersensitivity vasculitis in adults truly distinct entities? A dermatologist's perspective. ( 11138325 )
2000
23
Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-SchAPnlein purpura in adults. ( 10406408 )
1999
24
Hypersensitivity vasculitis (microscopic polyangiitis) in pregnancy with transmission to the neonate. ( 9746391 )
1998
25
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. ( 9724175 )
1998
26
Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. ( 9790279 )
1998
27
Bilateral leg pain and bruising. Hypersensitivity vasculitis. ( 9305435 )
1997
28
Hypersensitivity vasculitis. ( 9329546 )
1997
29
Hypersensitivity vasculitis--not always benign? ( 9251631 )
1997
30
Severe cutaneous thrombotic hypersensitivity vasculitis. ( 9385997 )
1997
31
Hypersensitivity vasculitis related to aceclofenac. ( 9159552 )
1997
32
Clinical features and outcome of 95 patients with hypersensitivity vasculitis. ( 9217569 )
1997
33
Case report: ofloxacin-induced hypersensitivity vasculitis. ( 8615379 )
1996
34
Nonsteroidal antiinflammatory drug induced hypersensitivity vasculitis clinically mimicking temporal arteritis. ( 8838531 )
1996
35
Therapy of resistant systemic necrotizing vasculitis. Polyarteritis, Churg-Strauss syndrome, Wegener's granulomatosis, and hypersensitivity vasculitis group disorders. ( 7732173 )
1995
36
Idiopathic hypersensitivity vasculitis: clinicopathologic correlation of 61 cases. ( 8543412 )
1995
37
Hypersensitivity vasculitis associated with piperazine therapy. ( 8043407 )
1994
38
Hypersensitivity vasculitis of the duodenum. ( 8092020 )
1994
39
Ciprofloxacin-induced hypersensitivity vasculitis. ( 7941927 )
1994
40
Acute hantavirus infection presenting as hypersensitivity vasculitis with arthropathy. ( 8095959 )
1993
41
Ciprofloxacin induced hypersensitivity vasculitis syndrome. ( 8262601 )
1993
42
Hypersensitivity vasculitis and systemic lupus erythematosus induced by anticonvulsants. ( 8422654 )
1993
43
Hypersensitivity vasculitis related to nicoumalone. ( 8490477 )
1993
44
Hypersensitivity vasculitis and Henoch-SchAPnlein purpura: a comparison between the 2 disorders. ( 8350321 )
1993
45
Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis. ( 1555358 )
1992
46
Hypersensitivity vasculitis and Henoch-SchAPnlein purpura: a comparison between the 2 disorders. ( 1613701 )
1992
47
Propylthiouracil-induced hypersensitivity vasculitis presenting as respiratory failure. ( 1424898 )
1992
48
Elimination diet in the treatment of selected patients with hypersensitivity vasculitis. ( 1505105 )
1992
49
Systemic hypersensitivity vasculitis associated with bronchiectasis. ( 1386569 )
1992
50
Hypersensitivity vasculitis occurring in a patient receiving immunotherapy. ( 1826508 )
1991
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Variations for Hypersensitivity Vasculitis

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Expression for Hypersensitivity Vasculitis

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Search GEO for disease gene expression data for Hypersensitivity Vasculitis.
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Pathways for Hypersensitivity Vasculitis

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Pathways related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.35 C3 C4A CD40LG CD79A CRP HSP90AA1
2
Allograft rejection 1 37
Show member pathways
 12.3 C3 C4A CD40LG HSP90AA1
3
Creation of C4 and C2 activators 66
Show member pathways
 11.29 C3 C4A CRP
4
Immune response Lectin induced complement pathway 22
Show member pathways
 10.93 C3 C4A CRP
5
Primary immunodeficiency 37
10.89 CD40LG CD79A
Sources

GO Terms for Hypersensitivity Vasculitis

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Biological processes related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.62 C3 C4A CD79A MEFV
2 innate immune response GO:0045087 9.56 C3 C4A CRP MEFV
3 B cell proliferation GO:0042100 9.37 CD40LG CD79A
4 complement activation, classical pathway GO:0006958 9.33 C3 C4A CRP
5 inflammatory response GO:0006954 9.02 C3 C4A CD40LG CRP MEFV
6 positive regulation of apoptotic cell clearance GO:2000427 8.96 C3 C4A

Molecular functions related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement component C1q binding GO:0001849 8.62 C4A CRP
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Sources for Hypersensitivity Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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