MCID: HYP074
MIFTS: 54

Hypersensitivity Vasculitis

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hypersensitivity Vasculitis

MalaCards integrated aliases for Hypersensitivity Vasculitis:

Name: Hypersensitivity Vasculitis 12 54 15 17
Cutaneous Small Vessel Vasculitis 54 60 74
Vasculitis, Leukocytoclastic, Cutaneous 45 74
Cutaneous Leukocytoclastic Vasculitis 54
Cutaneous Hypersensitivity Vasculitis 60
Cutaneous Leukocytoclastic Angiitis 54
Drug Induced Cutaneous Vasculitis 74
Vasculitis Hypersensitivity 77
Leukocytoclastic Vasculitis 74
Hypersensitivity Angiitis 54
Leukocytoclastic Angiitis 54

Characteristics:

Orphanet epidemiological data:

60
cutaneous small vessel vasculitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Hypersensitivity Vasculitis

NIH Rare Diseases : 54 Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance that leads to inflammation and damage to blood vessels of the skin. Signs and symptoms may include purple-colored spots and patches on the skin; skin lesions on the legs, buttocks, or trunk; blisters on the skin; hives (urticaria); and/or open sores with dead tissue (necrotic ulcers). This condition is caused by an allergic reaction to a drug or other foreign substance. This condition usually goes away over time; but on occasion, people can have repeated episodes.

MalaCards based summary : Hypersensitivity Vasculitis, also known as cutaneous small vessel vasculitis, is related to vasculitis and henoch-schoenlein purpura, and has symptoms including purpura An important gene associated with Hypersensitivity Vasculitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and Phagosome. The drugs Dapsone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and breast, and related phenotypes are fever and myalgia

Disease Ontology : 12 A hypersensitivity reaction type III disease that is characterized by inflammation and injury to blood vessels and has symptom purpura, telangiectasia, blistering, urticaria, and ulcers.

Wikipedia : 77 Cutaneous small-vessel vasculitis (CSVV), also known as hypersensitivity vasculitis, cutaneous... more...

Related Diseases for Hypersensitivity Vasculitis

Diseases related to Hypersensitivity Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 vasculitis 31.4 CRP MEFV MPO
2 henoch-schoenlein purpura 31.1 C1GALT1 C3 CD79A CRP HSP90AA1 MEFV
3 polyarteritis nodosa 30.3 CRP MEFV MPO
4 mononeuritis multiplex 30.2 CRP MPO
5 behcet syndrome 30.2 C4A CRP MEFV
6 myeloma, multiple 30.1 CD79A CRP HSP90AA1
7 purpura 30.1 C4B CD79A CRP
8 microscopic polyangiitis 29.9 HLA-DRB1 MPO
9 lupus erythematosus 29.4 C3 C4A C4B
10 systemic lupus erythematosus 27.7 ACE C3 C4A C4B CD79A CRP
11 allergic cutaneous vasculitis 11.2
12 goodpasture syndrome 10.4
13 aortitis 10.4 CRP MPO
14 mediastinitis 10.4 CRP MPO
15 monoclonal paraproteinemia 10.4 HSP90AA1 MPO
16 acquired angioedema 10.4 C3 CRP
17 rapidly progressive glomerulonephritis 10.4 CRP MPO
18 acute maxillary sinusitis 10.4 C3 CRP
19 pulmonary aspergilloma 10.4 CRP MPO
20 relapsing fever 10.4 CRP MEFV
21 amyloidosis aa 10.4 CRP MEFV
22 chronic monocytic leukemia 10.4 C3 MPO
23 pleural empyema 10.3 CD79A CRP
24 pericardium disease 10.3 CRP MEFV
25 ascending cholangitis 10.3 C3 MPO
26 arteriolosclerosis 10.3 C3 CD79A
27 complement deficiency 10.3 C3 C4A
28 ulcerative stomatitis 10.3 CD79A MPO
29 lemierre's syndrome 10.3 C3 CRP
30 renal tuberculosis 10.3 CD79A CRP
31 chronic maxillary sinusitis 10.3 C3 MPO
32 generalized atherosclerosis 10.3 ACE CRP
33 muckle-wells syndrome 10.3 CRP MEFV
34 wells syndrome 10.2 CRP MEFV
35 pleurisy 10.2 CRP MEFV MPO
36 peritonitis 10.2 CRP MEFV MPO
37 immunoglobulin alpha deficiency 10.2 C4A CD79A
38 pulmonary hemosiderosis 10.2 CRP MPO
39 hydrarthrosis 10.2 C4A MEFV
40 proctitis 10.2 CRP MPO
41 ischemic heart disease 10.2 ACE CRP
42 subdural empyema 10.2 ACE CRP
43 testicular torsion 10.2 ACE CD79A
44 proliferative glomerulonephritis 10.2 C3 CD79A MPO
45 anca-associated vasculitis 10.2 HLA-DRB1 MPO
46 idiopathic edema 10.2 ACE MPO
47 adult-onset still's disease 10.2 CRP MEFV
48 central nervous system vasculitis 10.2 CRP HLA-DRB1
49 granulomatous angiitis 10.1 ACE CRP
50 mesangial proliferative glomerulonephritis 10.1 CD79A SPG7

Comorbidity relations with Hypersensitivity Vasculitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Postinflammatory Pulmonary Fibrosis
Rheumatoid Arthritis Systemic Lupus Erythematosus

Graphical network of the top 20 diseases related to Hypersensitivity Vasculitis:



Diseases related to Hypersensitivity Vasculitis

Symptoms & Phenotypes for Hypersensitivity Vasculitis

Human phenotypes related to Hypersensitivity Vasculitis:

60 33 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
3 purpura 60 33 hallmark (90%) Very frequent (99-80%) HP:0000979
4 erythema 60 33 hallmark (90%) Very frequent (99-80%) HP:0010783
5 urticaria 60 33 hallmark (90%) Very frequent (99-80%) HP:0001025
6 vasculitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002633
7 papule 60 33 hallmark (90%) Very frequent (99-80%) HP:0200034
8 gangrene 60 33 hallmark (90%) Very frequent (99-80%) HP:0100758
9 cutis marmorata 60 33 hallmark (90%) Very frequent (99-80%) HP:0000965
10 recurrent skin infections 60 33 hallmark (90%) Very frequent (99-80%) HP:0001581
11 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
12 skin rash 60 33 frequent (33%) Frequent (79-30%) HP:0000988
13 subcutaneous nodule 60 33 occasional (7.5%) Occasional (29-5%) HP:0001482
14 abnormal oral cavity morphology 33 occasional (7.5%) HP:0000163
15 abnormality of the oral cavity 60 Occasional (29-5%)

Symptoms:

12
  • purpura

GenomeRNAi Phenotypes related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.77 C4A C4B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.77 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.77 C4A C4B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.77 C4A C4B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.77 CRP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.77 C4A C4B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.77 CRP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.77 C4A C4B CRP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 CD79A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 C4A C4B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.77 C4A C4B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.77 CRP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 C4A C4B CD79A CRP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.77 CD79A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.77 CD79A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.77 C4A C4B

MGI Mouse Phenotypes related to Hypersensitivity Vasculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ACE C1GALT1 C3 C4B CD79A CRP

Drugs & Therapeutics for Hypersensitivity Vasculitis

Drugs for Hypersensitivity Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
leucovorin Approved Phase 4 58-05-9 143 6006
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Antimalarials Phase 4
5 Folic Acid Antagonists Phase 4
6 Vitamin B9 Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Vitamin B Complex Phase 4
10 Anti-Infective Agents Phase 4,Not Applicable
11 Folate Phase 4
12 Anti-Bacterial Agents Phase 4
13 Omega 3 Fatty Acid Phase 4
14
Talimogene laherparepvec Approved, Experimental, Investigational Phase 1, Phase 2 1187560-31-1
15
Ipilimumab Approved Phase 1, Phase 2 477202-00-9
16 Antineoplastic Agents, Immunological Phase 1, Phase 2
17
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
18
Lenograstim Approved, Investigational Not Applicable 135968-09-1
19
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
20
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
21
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
22
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
23
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
24
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
25
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
26 Immunologic Factors ,Not Applicable
27 Antibodies
28 Immunoglobulin A
29 Immunoglobulins
30 Antigen-Antibody Complex
31 Hormone Antagonists Not Applicable
32 Immunosuppressive Agents Not Applicable
33 Autonomic Agents Not Applicable
34 Cyclosporins Not Applicable
35 Antirheumatic Agents Not Applicable
36 Methylprednisolone Acetate Not Applicable
37 Protective Agents Not Applicable
38 Antifungal Agents Not Applicable
39 Antineoplastic Agents, Alkylating Not Applicable
40 Dermatologic Agents Not Applicable
41 glucocorticoids Not Applicable
42 Peripheral Nervous System Agents Not Applicable
43 Antineoplastic Agents, Hormonal Not Applicable
44 Antiemetics Not Applicable
45 Antilymphocyte Serum Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
47 Calcineurin Inhibitors Not Applicable
48 Gastrointestinal Agents Not Applicable
49 Alkylating Agents Not Applicable
50 Hormones Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Unknown status NCT02550080 Phase 4 Dapsone
2 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
3 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
4 IgA-positive Versus IgA-negative Immune Complex Vasculitis Unknown status NCT01815190
5 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
6 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
7 Study to Determine the Hepatitis C Virus Infection Prevalence Among Patients Attended Primarily for Vasculitis Recruiting NCT03693586

Search NIH Clinical Center for Hypersensitivity Vasculitis

Cochrane evidence based reviews: vasculitis, leukocytoclastic, cutaneous

Genetic Tests for Hypersensitivity Vasculitis

Anatomical Context for Hypersensitivity Vasculitis

MalaCards organs/tissues related to Hypersensitivity Vasculitis:

42
Skin, Thyroid, Breast, Bone, Heart, Liver, Colon

Publications for Hypersensitivity Vasculitis

Articles related to Hypersensitivity Vasculitis:

(show top 50) (show all 98)
# Title Authors Year
1
Cutaneous small-vessel vasculitis associated with paediatric ulcerative colitis: A case study and literature review. ( 30895688 )
2019
2
A Unique Case Report on Hypersensitivity Vasculitis as an Allergic Reaction to the Herpes Zoster Vaccine. ( 30122132 )
2019
3
Paraneoplastic cutaneous small-vessel vasculitis as a presentation of recurrent metastatic breast cancer. ( 29984288 )
2018
4
Checkpoint inhibitor-associated cutaneous small vessel vasculitis. ( 30112452 )
2018
5
Role of Direct Immunofluorescence in Cutaneous Small-Vessel Vasculitis: Experience From a Tertiary Center. ( 29672364 )
2018
6
Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis. ( 29441165 )
2018
7
Premature diagnosis of calciphylaxis without pathological indications finally diagnosed as cutaneous small-vessel vasculitis: a post-mortem case report. ( 30549918 )
2017
8
Cutaneous Small-Vessel Vasculitis in Two Children with Inflammatory Bowel Disease: Case Series and Review of the Literature. ( 28771805 )
2017
9
Successful Treatment of Cutaneous Small Vessel Vasculitis With Leflunomide. ( 28614577 )
2017
10
Single-organ cutaneous small-vessel vasculitis according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides: a study of 60 patients from a series of 766 cutaneous vasculitis cases. ( 25065012 )
2015
11
Carbimazole-associated hypersensitivity vasculitis in a cat. ( 24255992 )
2014
12
Revisiting clinical differences between hypersensitivity vasculitis and Henoch-Schönlein purpura in adults from a defined population. ( 24528895 )
2014
13
A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. ( 24756249 )
2014
14
Histopathological findings in cutaneous small-vessel vasculitis associated with solid-organ malignancy. ( 24958433 )
2014
15
Paracetamol-induced hypersensitivity vasculitis in a 10-year-old child. ( 24379075 )
2013
16
Cutaneous small vessel vasculitis accompanied by pustulosis palmaris et plantaris. ( 22548039 )
2012
17
Cutaneous small-vessel vasculitis associated with solid organ malignancies: the Mayo Clinic experience, 1996 to 2009. ( 21093106 )
2012
18
Treatment of severe cutaneous small-vessel vasculitis with mycophenolate mofetil. ( 22911181 )
2012
19
Ink sick: tattoo ink hypersensitivity vasculitis. ( 21035978 )
2011
20
Hepatitis C- and human immunodeficiency virus-induced hypersensitivity vasculitis: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. ( 19921341 )
2010
21
Hypersensitivity vasculitis associated with leuprolide (Lupron). ( 20470239 )
2010
22
Utilizing active Leptospermum honey dressings in the treatment of cutaneous small-vessel vasculitis. ( 20560242 )
2010
23
A stinging rash of indeterminate origin. Idiopathic hypersensitivity vasculitis. ( 19235501 )
2009
24
Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor. ( 20204065 )
2009
25
Isomorphic response of Koebner in a patient with cutaneous small vessel vasculitis. ( 18355213 )
2008
26
Immunological diagnosis of cutaneous-pulmonary hypersensitivity vasculitis. ( 17332983 )
2007
27
A case of hypersensitivity vasculitis after vinorelbine injection in a patient with metastatic breast cancer. ( 17419038 )
2007
28
A large ulcer and cutaneous small-vessel vasculitis associated with syphilis infection. ( 16641051 )
2006
29
Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis. ( 16490843 )
2006
30
Primary cutaneous small vessel vasculitis: approach to diagnosis and treatment. ( 16426368 )
2006
31
Cutaneous small vessel vasculitis and pulmonary tuberculosis: an unusual association. ( 16911400 )
2006
32
Prevalence of human parvovirus B19 component NS1 gene in patients with Henoch-Schonlein purpura and hypersensitivity vasculitis. ( 15888184 )
2005
33
Renal hypersensitivity vasculitis associated with dapsone. ( 16183407 )
2005
34
Cutaneous small-vessel vasculitis with unexpected circulating and in situ bound pemphigus autoantibodies. ( 16409915 )
2005
35
Case reports: cutaneous small vessel vasculitis due to famciclovir therapy. ( 16004023 )
2005
36
Primary Cutaneous Small Vessel Vasculitis. ( 15066243 )
2004
37
Hypersensitivity vasculitis induced by cefoperazone/sulbactam. ( 12556245 )
2003
38
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. ( 12700924 )
2003
39
Hypersensitivity vasculitis with leukocytoclastic vasculitis secondary to infliximab. ( 12702983 )
2003
40
Hypersensitivity vasculitis and cytokines. ( 12426663 )
2002
41
Hypersensitivity vasculitis induced by cefprozil. ( 17159422 )
2002
42
Cutaneous small vessel vasculitis: an entity with frequent renal involvement. ( 11903003 )
2002
43
Platelet involvement in cutaneous small vessel vasculitis. ( 11972716 )
2002
44
Hypersensitivity vasculitis in adults: a benign disease usually limited to skin. ( 11247332 )
2001
45
Are Henoch-Schönlein purpura and hypersensitivity vasculitis in adults truly distinct entities? A dermatologist's perspective. ( 11138325 )
2000
46
Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-Schönlein purpura in adults. ( 10406408 )
1999
47
Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. ( 9790279 )
1998
48
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. ( 9724175 )
1998
49
Hypersensitivity vasculitis (microscopic polyangiitis) in pregnancy with transmission to the neonate. ( 9746391 )
1998
50
Cutaneous small-vessel vasculitis. ( 9810883 )
1998

Variations for Hypersensitivity Vasculitis

Expression for Hypersensitivity Vasculitis

Search GEO for disease gene expression data for Hypersensitivity Vasculitis.

Pathways for Hypersensitivity Vasculitis

GO Terms for Hypersensitivity Vasculitis

Cellular components related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE C3 C4A C4B CRP MPO
2 extracellular region GO:0005576 9.7 ACE C3 C4A C4B CRP HSP90AA1
3 extracellular exosome GO:0070062 9.17 ACE C3 C4A C4B HLA-DRB1 HSP90AA1
4 blood microparticle GO:0072562 9.13 C3 C4A C4B

Biological processes related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.72 C3 C4A C4B CRP MEFV
2 negative regulation of endopeptidase activity GO:0010951 9.65 C3 C4A C4B
3 regulation of complement activation GO:0030449 9.63 C3 C4A C4B
4 complement activation GO:0006956 9.58 C3 C4A C4B
5 complement activation, classical pathway GO:0006958 9.56 C3 C4A C4B CRP
6 inflammatory response GO:0006954 9.55 C3 C4A C4B CRP MEFV
7 protein tetramerization GO:0051262 9.49 HLA-DRB1 SLC26A5
8 proteolysis GO:0006508 9.43 ACE SPG7
9 immune system process GO:0002376 9.43 C3 C4A C4B CD79A HLA-DRB1 MEFV
10 opsonization GO:0008228 9.37 C4B CRP
11 positive regulation of apoptotic cell clearance GO:2000427 8.8 C3 C4A C4B

Molecular functions related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II protein complex binding GO:0023026 9.16 HLA-DRB1 HSP90AA1
2 complement component C1q binding GO:0001849 8.96 C4A CRP
3 endopeptidase inhibitor activity GO:0004866 8.8 C3 C4A C4B

Sources for Hypersensitivity Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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