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MCID: HYP074
MIFTS: 49

Hypersensitivity Vasculitis

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Hypersensitivity Vasculitis

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MalaCards integrated aliases for Hypersensitivity Vasculitis:

Name: Hypersensitivity Vasculitis 12 53 15
Cutaneous Small Vessel Vasculitis 53 59 73
Vasculitis, Leukocytoclastic, Cutaneous 44 73
Cutaneous Leukocytoclastic Vasculitis 53 59
Cutaneous Leukocytoclastic Angiitis 53 59
Hypersensitivity Angiitis 53 59
Cutaneous Hypersensitivity Vasculitis 59
Drug Induced Cutaneous Vasculitis 73
Vasculitis Hypersensitivity 76
Leukocytoclastic Vasculitis 73
Leukocytoclastic Angiitis 53

Characteristics:

Orphanet epidemiological data:

59
cutaneous leukocytoclastic angiitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Bone diseases Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare circulatory system diseases
Rare systemic and rhumatological diseases


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Summaries for Hypersensitivity Vasculitis

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NIH Rare Diseases : 53 Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance that leads to inflammation and damage to blood vessels of the skin. Signs and symptoms may include purple-colored spots and patches on the skin; skin lesions on the legs, buttocks, or trunk; blisters on the skin; hives (urticaria); and/or open sores with dead tissue (necrotic ulcers). This condition is caused by an allergic reaction to a drug or other foreign substance. This condition usually goes away over time; but on occasion, people can have repeated episodes.

MalaCards based summary : Hypersensitivity Vasculitis, also known as cutaneous small vessel vasculitis, is related to vasculitis and behcet syndrome. An important gene associated with Hypersensitivity Vasculitis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and Phagosome. The drugs leucovorin and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related phenotypes are fever and subcutaneous nodule

Wikipedia : 76 Cutaneous small-vessel vasculitis, also known as hypersensitivity vasculitis, cutaneous leukocytoclastic... more...

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Related Diseases for Hypersensitivity Vasculitis

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Diseases related to Hypersensitivity Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.8 CRP MEFV MPO PRTN3
2 behcet syndrome 30.1 C4A CRP MEFV
3 mononeuritis multiplex 30.0 CRP MPO
4 microscopic polyangiitis 29.9 HLA-DRB1 MPO
5 polyarteritis nodosa 29.7 CRP MEFV MPO PRTN3
6 churg-strauss syndrome 29.4 MPO PRTN3
7 systemic lupus erythematosus 28.4 ACE C3 C4A CD79A CRP HLA-DRB1
8 allergic cutaneous vasculitis 11.1
9 goodpasture syndrome 10.4
10 aortitis 10.3 CRP MPO
11 mediastinitis 10.3 CRP MPO
12 pleural empyema 10.2 CD79A CRP
13 pulmonary aspergilloma 10.2 CRP MPO
14 acquired angioedema 10.2 C3 CRP
15 relapsing fever 10.2 CRP MEFV
16 acute maxillary sinusitis 10.2 C3 CRP
17 amyloidosis aa 10.2 CRP MEFV
18 chronic monocytic leukemia 10.2 C3 MPO
19 ulcerative stomatitis 10.2 CD79A MPO
20 arteriolosclerosis 10.2 C3 CD79A
21 renal tuberculosis 10.2 CD79A CRP
22 pericardium disease 10.2 CRP MEFV
23 ascending cholangitis 10.2 C3 MPO
24 lemierre's syndrome 10.2 C3 CRP
25 pharyngitis 10.2 CRP MEFV
26 immunoglobulin alpha deficiency 10.2 C4A CD79A
27 muckle-wells syndrome 10.2 CRP MEFV
28 pediatric systemic lupus erythematosus 10.2 C3 C4A
29 generalized atherosclerosis 10.2 ACE CRP
30 wells syndrome 10.2 CRP MEFV
31 proctitis 10.2 CRP MPO
32 pleurisy 10.2 CRP MEFV MPO
33 central nervous system vasculitis 10.1 CRP HLA-DRB1
34 testicular torsion 10.1 ACE CD79A
35 peritonitis 10.1 CRP MEFV MPO
36 microscopic colitis 10.1 CD79A HLA-DRB1
37 ischemic heart disease 10.1 ACE CRP
38 purpura 10.1
39 adult-onset still's disease 10.1 CRP MEFV
40 proliferative glomerulonephritis 10.1 C3 CD79A MPO
41 subdural empyema 10.1 ACE CRP
42 idiopathic edema 10.1 ACE MPO
43 hepatitis c virus 10.1
44 cryoglobulinemia 10.1
45 viral infectious disease 10.1
46 acute proliferative glomerulonephritis 10.1 MPO PIGN
47 histoplasmosis 10.1 C3 HLA-DRB1
48 intermediate coronary syndrome 10.1 ACE CRP
49 complement deficiency 10.1 C3 C4A
50 autoimmune disease of musculoskeletal system 10.1 C3 C4A CRP

Comorbidity relations with Hypersensitivity Vasculitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Postinflammatory Pulmonary Fibrosis
Rheumatoid Arthritis Systemic Lupus Erythematosus

Graphical network of the top 20 diseases related to Hypersensitivity Vasculitis:



Diseases related to Hypersensitivity Vasculitis
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Symptoms & Phenotypes for Hypersensitivity Vasculitis

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Human phenotypes related to Hypersensitivity Vasculitis:

59 32 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
2 subcutaneous nodule 59 32 occasional (7.5%) Occasional (29-5%) HP:0001482
3 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
4 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
5 purpura 59 32 hallmark (90%) Very frequent (99-80%) HP:0000979
6 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
7 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
8 urticaria 59 32 hallmark (90%) Very frequent (99-80%) HP:0001025
9 vasculitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002633
10 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034
11 gangrene 59 32 hallmark (90%) Very frequent (99-80%) HP:0100758
12 cutis marmorata 59 32 hallmark (90%) Very frequent (99-80%) HP:0000965
13 recurrent skin infections 59 32 hallmark (90%) Very frequent (99-80%) HP:0001581
14 abnormality of the oral cavity 59 Occasional (29-5%)
15 abnormal oral cavity morphology 32 occasional (7.5%) HP:0000163

MGI Mouse Phenotypes related to Hypersensitivity Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ACE C1GALT1 C3 CD79A CRP HSP90AA1
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Drugs & Therapeutics for Hypersensitivity Vasculitis

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Drugs for Hypersensitivity Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Dapsone Approved, Investigational Phase 4 80-08-0 2955
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Anti-Infective Agents Phase 4,Not Applicable
5 Anti-Bacterial Agents Phase 4
6 Antiprotozoal Agents Phase 4
7 Vitamin B9 Phase 4
8 Vitamin B Complex Phase 4
9 Antimalarials Phase 4
10 Folic Acid Antagonists Phase 4
11 Antiparasitic Agents Phase 4
12 Folate Phase 4
13 Omega 3 Fatty Acid Phase 4
14 Antibodies Phase 1, Phase 2
15 Immunoglobulins Phase 1, Phase 2
16 Immunologic Factors Phase 1, Phase 2,Not Applicable
17 Antibodies, Monoclonal Phase 1, Phase 2
18
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
19
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
20
Lenograstim Approved, Investigational Not Applicable 135968-09-1
21
Cyclophosphamide Approved, Investigational Not Applicable 6055-19-2, 50-18-0 2907
22
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
23
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
24
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
25
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
26
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
27 Immunoglobulin A
28 Antigen-Antibody Complex
29 Antirheumatic Agents Not Applicable
30 Alkylating Agents Not Applicable
31 Neuroprotective Agents Not Applicable
32 Protective Agents Not Applicable
33 Autonomic Agents Not Applicable
34 Methylprednisolone acetate Not Applicable
35 Prednisolone acetate Not Applicable
36 Immunosuppressive Agents Not Applicable
37 Calcineurin Inhibitors Not Applicable
38 Antiemetics Not Applicable
39 Cyclosporins Not Applicable
40 Gastrointestinal Agents Not Applicable
41 Peripheral Nervous System Agents Not Applicable
42 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
43 Antineoplastic Agents, Alkylating Not Applicable
44 Hormone Antagonists Not Applicable
45 glucocorticoids Not Applicable
46 Antifungal Agents Not Applicable
47 Dermatologic Agents Not Applicable
48 Antineoplastic Agents, Hormonal Not Applicable
49 Hormones Not Applicable
50 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
2 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels Terminated NCT00578578 Phase 4
3 Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma Active, not recruiting NCT01740297 Phase 1, Phase 2 Talimogene laherparepvec;Ipilimumab
4 IgA-positive Versus IgA-negative Immune Complex Vasculitis Unknown status NCT01815190
5 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
6 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
7 Study to Determine the Hepatitis C Virus Infection Prevalence Among Patients Attended Primarily for Vasculitis Recruiting NCT03693586

Search NIH Clinical Center for Hypersensitivity Vasculitis

Cochrane evidence based reviews: vasculitis, leukocytoclastic, cutaneous

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Genetic Tests for Hypersensitivity Vasculitis

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Anatomical Context for Hypersensitivity Vasculitis

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MalaCards organs/tissues related to Hypersensitivity Vasculitis:

41
Skin, Bone, Thyroid, Lung, Heart, Myeloid, Monocytes
Sources

Publications for Hypersensitivity Vasculitis

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Articles related to Hypersensitivity Vasculitis:

(show top 50) (show all 98)
# Title Authors Year
1
Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis. ( 29441165 )
2018
2
Leukocytoclastic Vasculitis (Hypersensitivity Vasculitis) ( 29489227 )
2018
3
A Unique Case Report on Hypersensitivity Vasculitis as an Allergic Reaction to the Herpes Zoster Vaccine. ( 30122132 )
2018
4
Paraneoplastic cutaneous small-vessel vasculitis as a presentation of recurrent metastatic breast cancer. ( 29984288 )
2018
5
Checkpoint inhibitor-associated cutaneous small vessel vasculitis. ( 30112452 )
2018
6
Role of Direct Immunofluorescence in Cutaneous Small-Vessel Vasculitis: Experience From a Tertiary Center. ( 29672364 )
2018
7
Premature diagnosis of calciphylaxis without pathological indications finally diagnosed as cutaneous small-vessel vasculitis: a post-mortem case report. ( 30549918 )
2017
8
Successful Treatment of Cutaneous Small Vessel Vasculitis With Leflunomide. ( 28614577 )
2017
9
Cutaneous Small-Vessel Vasculitis in Two Children with Inflammatory Bowel Disease: Case Series and Review of the Literature. ( 28771805 )
2017
10
Single-organ cutaneous small-vessel vasculitis according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides: a study of 60 patients from a series of 766 cutaneous vasculitis cases. ( 25065012 )
2015
11
Revisiting clinical differences between hypersensitivity vasculitis and Henoch-SchAPnlein purpura in adults from a defined population. ( 24528895 )
2014
12
A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. ( 24756249 )
2014
13
Histopathological findings in cutaneous small-vessel vasculitis associated with solid-organ malignancy. ( 24958433 )
2014
14
Carbimazole-associated hypersensitivity vasculitis in a cat. ( 24255992 )
2013
15
Paracetamol-induced hypersensitivity vasculitis in a 10-year-old child. ( 24379075 )
2013
16
Cutaneous small vessel vasculitis accompanied by pustulosis palmaris et plantaris. ( 22548039 )
2012
17
Cutaneous small-vessel vasculitis associated with solid organ malignancies: the Mayo Clinic experience, 1996 to 2009. ( 21093106 )
2012
18
Treatment of severe cutaneous small-vessel vasculitis with mycophenolate mofetil. ( 22911181 )
2012
19
Ink sick: tattoo ink hypersensitivity vasculitis. ( 21035978 )
2011
20
Hypersensitivity vasculitis associated with leuprolide (Lupron). ( 20470239 )
2010
21
Hepatitis C- and human immunodeficiency virus-induced hypersensitivity vasculitis: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. ( 19921341 )
2010
22
Utilizing active Leptospermum honey dressings in the treatment of cutaneous small-vessel vasculitis. ( 20560242 )
2010
23
Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor. ( 20204065 )
2009
24
A stinging rash of indeterminate origin. Idiopathic hypersensitivity vasculitis. ( 19235501 )
2009
25
Isomorphic response of Koebner in a patient with cutaneous small vessel vasculitis. ( 18355213 )
2008
26
A case of hypersensitivity vasculitis after vinorelbine injection in a patient with metastatic breast cancer. ( 17419038 )
2007
27
Immunological diagnosis of cutaneous-pulmonary hypersensitivity vasculitis. ( 17332983 )
2007
28
Primary cutaneous small vessel vasculitis: approach to diagnosis and treatment. ( 16426368 )
2006
29
Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis. ( 16490843 )
2006
30
A large ulcer and cutaneous small-vessel vasculitis associated with syphilis infection. ( 16641051 )
2006
31
Cutaneous small vessel vasculitis and pulmonary tuberculosis: an unusual association. ( 16911400 )
2006
32
Prevalence of human parvovirus B19 component NS1 gene in patients with Henoch-Schonlein purpura and hypersensitivity vasculitis. ( 15888184 )
2005
33
Renal hypersensitivity vasculitis associated with dapsone. ( 16183407 )
2005
34
Case reports: cutaneous small vessel vasculitis due to famciclovir therapy. ( 16004023 )
2005
35
Cutaneous small-vessel vasculitis with unexpected circulating and in situ bound pemphigus autoantibodies. ( 16409915 )
2005
36
Primary Cutaneous Small Vessel Vasculitis. ( 15066243 )
2004
37
Hypersensitivity vasculitis with leukocytoclastic vasculitis secondary to infliximab. ( 12702983 )
2003
38
Hypersensitivity vasculitis induced by cefoperazone/sulbactam. ( 12556245 )
2003
39
Orbital inflammatory pseudotumor due to hypersensitivity vasculitis and mononeuritis multiplex in a patient with atypical, cANCA-positive Wegener's granulomatosis. ( 12700924 )
2003
40
Hypersensitivity vasculitis and cytokines. ( 12426663 )
2002
41
Hypersensitivity vasculitis induced by cefprozil. ( 17159422 )
2002
42
Cutaneous small vessel vasculitis: an entity with frequent renal involvement. ( 11903003 )
2002
43
Platelet involvement in cutaneous small vessel vasculitis. ( 11972716 )
2002
44
Hypersensitivity vasculitis in adults: a benign disease usually limited to skin. ( 11247332 )
2001
45
Are Henoch-SchAPnlein purpura and hypersensitivity vasculitis in adults truly distinct entities? A dermatologist's perspective. ( 11138325 )
2000
46
Comparative clinical and epidemiological study of hypersensitivity vasculitis versus Henoch-SchAPnlein purpura in adults. ( 10406408 )
1999
47
Hypersensitivity vasculitis (microscopic polyangiitis) in pregnancy with transmission to the neonate. ( 9746391 )
1998
48
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. ( 9724175 )
1998
49
Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. ( 9790279 )
1998
50
Cutaneous small-vessel vasculitis. ( 9810883 )
1998
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Variations for Hypersensitivity Vasculitis

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Expression for Hypersensitivity Vasculitis

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Search GEO for disease gene expression data for Hypersensitivity Vasculitis.
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Pathways for Hypersensitivity Vasculitis

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Pathways related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.2 C3 C4A CD79A CRP HLA-DRB1 HSP90AA1
2
Phagosome 37
11.68 C3 HLA-DRB1 MPO
3
Creation of C4 and C2 activators 66
Show member pathways
 11.59 C3 C4A CRP
4
Immune response Lectin induced complement pathway 22
Show member pathways
 11.46 C3 C4A CRP
5
Staphylococcus aureus infection 37
10.55 C3 C4A HLA-DRB1
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GO Terms for Hypersensitivity Vasculitis

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Cellular components related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 ACE C3 C4A CD79A HLA-DRB1 HSP90AA1
2 extracellular space GO:0005615 9.8 ACE C3 C4A CRP MPO PRTN3
3 extracellular region GO:0005576 9.7 ACE C3 C4A CRP HSP90AA1 MPO
4 extracellular exosome GO:0070062 9.5 ACE C3 C4A HLA-DRB1 HSP90AA1 MPO
5 azurophil granule lumen GO:0035578 8.8 C3 MPO PRTN3

Biological processes related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.67 C3 C4A CRP MEFV
2 neutrophil degranulation GO:0043312 9.62 C3 HSP90AA1 MPO PRTN3
3 inflammatory response GO:0006954 9.46 C3 C4A CRP MEFV
4 complement activation, classical pathway GO:0006958 9.43 C3 C4A CRP
5 protein tetramerization GO:0051262 9.4 HLA-DRB1 SLC26A5
6 immune system process GO:0002376 9.35 C3 C4A CD79A HLA-DRB1 MEFV
7 positive regulation of apoptotic cell clearance GO:2000427 8.62 C3 C4A

Molecular functions related to Hypersensitivity Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 9.16 C3 C4A
2 MHC class II protein complex binding GO:0023026 8.96 HLA-DRB1 HSP90AA1
3 complement component C1q binding GO:0001849 8.62 C4A CRP
Sources

Sources for Hypersensitivity Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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