MCID: HYP263
MIFTS: 36

Hypersomnia

Categories: Neuronal diseases, Mental diseases

Aliases & Classifications for Hypersomnia

MalaCards integrated aliases for Hypersomnia:

Name: Hypersomnia 54 73

Classifications:



External Ids:

UMLS 73 C0917799

Summaries for Hypersomnia

NINDS : 54 Hypersomnia is characterized by recurrent episodes of excessive daytime sleepiness or prolonged nighttime sleep. Different from feeling tired due to lack of or interrupted sleep at night, persons with hypersomnia are compelled to nap repeatedly during the day, often at inappropriate times such as at work, during a meal, or in conversation. These daytime naps usually provide no relief from symptoms. Patients often have difficulty waking from a long sleep, and may feel disoriented. Other symptoms may include anxiety, increased irritation, decreased energy, restlessness, slow thinking, slow speech, loss of appetite, hallucinations, and memory difficulty. Some patients lose the ability to function in family, social, occupational, or other settings. Hypersomnia may be caused by another sleep disorder (such as narcolepsy or sleep apnea), dysfunction of the autonomic nervous system, or drug or alcohol abuse. In some cases it results from a physical problem, such as a tumor, head trauma, or injury to the central nervous system. Certain medications, or medicine withdrawal, may also cause hypersomnia. Medical conditions including multiple sclerosis, depression, encephalitis, epilepsy, or obesity may contribute to the disorder. Some people appear to have a genetic predisposition to hypersomnia; in others, there is no known cause. Typically, hypersomnia is first recognized in adolescence or young adulthood.

MalaCards based summary : Hypersomnia is related to idiopathic hypersomnia and recurrent hypersomnia, and has symptoms including sleep disturbances, snoring and excessive daytime somnolence. An important gene associated with Hypersomnia is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Phagosome and Immune response Antigen presentation by MHC class II. Affiliated tissues include testes, brain and hypothalamus.

Wikipedia : 76 Hypersomnia, or hypersomnolence, is a neurological disorder of excessive time spent sleeping or... more...

Related Diseases for Hypersomnia

Diseases in the Hypersomnia family:

Recurrent Hypersomnia

Diseases related to Hypersomnia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 idiopathic hypersomnia 34.0 HCRT HLA-DQB1
2 recurrent hypersomnia 33.6 HCRT HLA-DQB1
3 kleine-levin hibernation syndrome 32.3 HCRT HLA-DQB1
4 whipple disease 29.8 HLA-DQB1 HLA-DRB1
5 neuromyelitis optica 29.3 HCRT HLA-DRB1
6 acute disseminated encephalomyelitis 29.1 HCRT HLA-DQB1 HLA-DRB1
7 narcolepsy 27.8 CHKB CPT1B HCRT HLA-DQB1 HLA-DRB1
8 idiopathic hypersomnia without long sleep time 12.1
9 idiopathic hypersomnia with long sleep time 12.0
10 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 11.2
11 myotonic dystrophy 2 10.9
12 atypical depressive disorder 10.9
13 depression 10.3
14 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
15 metal allergy 10.3 HLA-DQB1 HLA-DRB1
16 focal epithelial hyperplasia 10.3 HLA-DQB1 HLA-DRB1
17 sleep apnea 10.3
18 lichen planopilaris 10.3 HLA-DQB1 HLA-DRB1
19 type ii mixed cryoglobulinemia 10.3 HLA-DQB1 HLA-DRB1
20 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
21 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
22 autoimmune pancreatitis 10.2 HLA-DQB1 HLA-DRB1
23 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
24 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
25 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
26 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
27 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1
28 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
29 peanut allergy 10.2 HLA-DQB1 HLA-DRB1
30 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DQB1 HLA-DRB1
31 panuveitis 10.1 HLA-DQB1 HLA-DRB1
32 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
33 severe hemophilia a 10.1 HLA-DQB1 HLA-DRB1
34 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
35 paraneoplastic pemphigus 10.1 HLA-DQB1 HLA-DRB1
36 myotonic dystrophy 10.1
37 myotonia atrophica 10.1
38 sleep disorder 10.0
39 vogt-koyanagi-harada disease 10.0 HLA-DQB1 HLA-DRB1
40 rubella 10.0 HLA-DQB1 HLA-DRB1
41 traumatic brain injury 10.0
42 major depressive disorder 10.0
43 bipolar disorder 10.0
44 brain injury 10.0
45 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1
46 prader-willi syndrome 9.9
47 mood disorder 9.9
48 neuronitis 9.9
49 guillain-barre syndrome 9.9 HCRT HLA-DQB1
50 autoimmune hepatitis 9.9 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Hypersomnia:



Diseases related to Hypersomnia

Symptoms & Phenotypes for Hypersomnia

UMLS symptoms related to Hypersomnia:


sleep disturbances, snoring, excessive daytime somnolence, sleeplessness, [d]sleep disturbances (& [hypersomnia] or [insomnia]), insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

Drugs & Therapeutics for Hypersomnia

Search Clinical Trials , NIH Clinical Center for Hypersomnia

Genetic Tests for Hypersomnia

Anatomical Context for Hypersomnia

MalaCards organs/tissues related to Hypersomnia:

41
Testes, Brain, Hypothalamus, Eye, Pituitary, Amygdala, Heart

Publications for Hypersomnia

Articles related to Hypersomnia:

(show top 50) (show all 377)
# Title Authors Year
1
Update on treatment for idiopathic hypersomnia. ( 29250981 )
2018
2
Insomnia and hypersomnia in major depressive episode: Prevalence, sociodemographic characteristics and psychiatric comorbidity in a population-based study. ( 28972930 )
2018
3
A case report of hypersomnia in tetrasomy X improved with medical therapy. ( 29744081 )
2018
4
Prevalence, risk factors, and response to treatment for hypersomnia of central origin in survivors of childhood brain tumors. ( 29116485 )
2018
5
Alternative diagnostic criteria for idiopathic hypersomnia: A 32-hour protocol. ( 29323727 )
2018
6
Idiopathic Hypersomnia Patients Revealed Longer Circadian Period Length in Peripheral Skin Fibroblasts. ( 29930532 )
2018
7
Hypersomnia due to injury of the lower ventral ascending reticular activating system in a patient with intraventricular hemorrhage. ( 29966809 )
2018
8
Associations Between Neuropsychological, Neurobehavioral and Emotional Functioning and Either Narcolepsy or Idiopathic Hypersomnia in Children and Adolescents. ( 29609710 )
2018
9
Nocturnal sleep architecture in idiopathic hypersomnia: a systematic review and meta-analysis. ( 29680423 )
2018
10
Drugs Used in Narcolepsy and Other Hypersomnias. ( 29759269 )
2018
11
A Case of Recurrent Hypersomnia With Autonomic Dysfunction. ( 28633719 )
2017
12
Treatment of narcolepsy and other organic hypersomnias in children. ( 28735675 )
2017
13
[18F]Fludeoxyglucose-Positron Emission Tomography Evidence for Cerebral Hypermetabolism in the Awake State in Narcolepsy and Idiopathic Hypersomnia. ( 28775709 )
2017
14
Hypersomnia: Evaluation, Treatment, and Social and Economic Aspects. ( 28159097 )
2017
15
Hypersomnolence, Hypersomnia, and Mood Disorders. ( 28243864 )
2017
16
Brain MRI findings in patients with idiopathic hypersomnia. ( 28376374 )
2017
17
Recurrent Hypersomnia and Autonomic Dysregulation in Posttraumatic Stress Disorder. ( 29117891 )
2017
18
Hypersomnia hiding a bipolar disorder. ( 28687972 )
2017
19
Test-Retest Reliability of Two Consecutive Mean Sleep Latency Tests in Patients with Hypersomnia. ( 29249902 )
2017
20
Narcolepsy and Other Central Hypersomnias. ( 28777172 )
2017
21
Efficacy, Safety, and Tolerability of Armodafinil Therapy for Hypersomnia Associated with Dementia with Lewy Bodies: A Pilot Study. ( 28448998 )
2017
22
Hypersomnia in Neurodegenerative Diseases. ( 28778241 )
2017
23
Life-time history of insomnia and hypersomnia symptoms as correlates of alcohol, cocaine and heroin use and relapse among adults seeking substance use treatment in the United States from 1991 to 1994. ( 28127809 )
2017
24
Val158Met polymorphism in the COMT gene is associated with hypersomnia and mental health-related quality of life in a Colombian sample. ( 28235603 )
2017
25
Neurobiological Basis of Hypersomnia. ( 28778226 )
2017
26
Narcolepsy type 1 and hypersomnia associated with a psychiatric disorder show different slow wave activity dynamics. ( 28691719 )
2017
27
Usefulness of brain SPECT imaging in the study of recurrent hypersomnia: Kleine-Levin syndrome. ( 28869046 )
2017
28
Narcolepsy and hypersomnia in Norwegian children and young adults following the influenza A(H1N1) 2009 pandemic. ( 28302408 )
2017
29
A case of hypersomnia due to bilateral thalamic stroke. ( 29026583 )
2017
30
Hypersomnia: an overlooked, but not overestimated, sleep disturbance in bipolar disorder. ( 28235881 )
2017
31
Depression and Hypersomnia: A Complex Association. ( 28778237 )
2017
32
Idiopathic Hypersomnia. ( 28778232 )
2017
33
Case Report of a Patient With Idiopathic Hypersomnia and a Family History of Malignant Hyperthermia Undergoing General Anesthesia: An Overview of the Anesthetic Considerations. ( 28328583 )
2017
34
Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia. ( 28958044 )
2017
35
Diffusion tensor imaging tractography and MRI perfusion in post traumatic brain injury hypersomnia. ( 28522105 )
2017
36
Hypersomnia and cognitive impairment in a patient with bipolar disorder - a case report. ( 28866718 )
2017
37
Urine Toxicology in Adults Evaluated for a Central Hypersomnia and How the Results Modify the Physician's Diagnosis. ( 27568897 )
2016
38
Benefits and risk of sodium oxybate in idiopathic hypersomnia versus narcolepsy type 1: a chart review. ( 26847972 )
2016
39
Menstruation-Related Hypersomnia Treated with Hormonal Contraception: Case Report and Review of Literature. ( 26932284 )
2016
40
Diurnal and nocturnal cardiovascular variability and heart rate arousal response in idiopathic hypersomnia. ( 27810179 )
2016
41
Injury of the Ascending Reticular Activating System in Patients With Fatigue and Hypersomnia Following Mild Traumatic Brain Injury: Two Case Reports. ( 26871783 )
2016
42
French consensus. Idiopathic hypersomnia: Investigations and follow-up. ( 27838089 )
2016
43
Behavioral Sleep Medicine Services for Hypersomnia Disorders: A Survey Study. ( 26788889 )
2016
44
Idiopathic Hypersomnia and Hypersomnolence Disorder: A Systematic Review of the Literature. ( 26895727 )
2016
45
Evaluation of polygenic risks for narcolepsy and essential hypersomnia. ( 27305985 )
2016
46
Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). ( 27343267 )
2016
47
Post-stroke hypersomnia. ( 26763039 )
2016
48
Disorders of Excessive Daytime Sleepiness Including Narcolepsy and Idiopathic Hypersomnia. ( 27542882 )
2016
49
Hypersomnia as the first presentation in a patient with insulinoma: A case report and review of the literature. ( 27699047 )
2016
50
Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias. ( 28083611 )
2016

Variations for Hypersomnia

Expression for Hypersomnia

Search GEO for disease gene expression data for Hypersomnia.

Pathways for Hypersomnia

GO Terms for Hypersomnia

Cellular components related to Hypersomnia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.4 HLA-DQB1 HLA-DRB1
2 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
3 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
4 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Hypersomnia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.4 HLA-DQB1 HLA-DRB1
2 T cell costimulation GO:0031295 9.37 HLA-DQB1 HLA-DRB1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.32 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation GO:0019882 9.26 HLA-DQB1 HLA-DRB1
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Hypersomnia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Hypersomnia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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