Hypersplenism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP063 MIFTS: 51	Hypersplenism Categories: Blood diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Hypersplenism

MalaCards integrated aliases for Hypersplenism:

Name: Hypersplenism ¹¹ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹ ⁷⁵ ³¹ ³³

Hypersplenia ¹¹ ³³

Increased Splenic Activity ³³

Hyperfunction of Spleen ³³

Big Spleen Syndrome ³³

Splenic Metaplasia ³³

Spleen Metaplasia ³³

Classifications:

MalaCards categories:
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Diseases of spleen

Hypersplenism

ICD11: ³³

Diseases of the blood or blood-forming organs

Diseases of spleen

Acquired disorders of spleen

Hypersplenism

External Ids:

Disease Ontology ¹¹ DOID:6376

ICD9CM ³⁴ 289.4

MeSH ⁴³ D006971

NCIt ⁴⁹ C34714

SNOMED-CT ⁶⁸ 154839008

ICD10 ³¹ D73.1

EFO ¹⁶ EFO_1000975

ICD11 ³³ 2093549625

UMLS ⁷¹ C0020532

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Summaries for Hypersplenism

MalaCards based summary: Hypersplenism, also known as hypersplenia, is related to purpura and thrombocytopenic purpura, autoimmune. An important gene associated with Hypersplenism is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation. The drugs Warfarin and Acetylsalicylic acid have been mentioned in the context of this disorder. Affiliated tissues include spleen, bone marrow and bone, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Wikipedia: ⁷⁵ Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ)... more...

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Related Diseases for Hypersplenism

Diseases related to Hypersplenism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)

#	Related Disease	Score	Top Affiliating Genes
1	purpura	30.6	THPO SERPINC1 F2
2	thrombocytopenic purpura, autoimmune	30.5	THPO F2 CD4
3	sickle cell anemia	30.4	SERPINC1 F2 EPO CSF3 CD4 ALB
4	liver cirrhosis	30.4	THPO SERPINC1 GPT F2 ALB AFP
5	aplastic anemia	30.4	U2AF1 THPO EPO CSF3 CSF2 CD4
6	thalassemia	30.4	GPT F2 EPO ALB
7	thrombocytopenia due to platelet alloimmunization	30.4	U2AF1 THPO CD4
8	schistosomiasis	30.4	GPT F2 ALB
9	wilson disease	30.3	GPT F2 ALB
10	anemia, autoimmune hemolytic	30.3	FOXP3 EPO CD4
11	peritonitis	30.3	TLR4 F2 CSF3 ALB
12	splenic tuberculosis	30.3	F2 CD4 ALB
13	granulocytopenia	30.3	CSF3 CSF2
14	splenic infarction	30.2	U2AF1 SERPINC1 GPT F2 ALB
15	endocarditis	30.2	SERPINC1 F2 ALB
16	hepatic encephalopathy	30.2	GPT F2 ALB
17	paralytic ileus	30.2	GPT F2 ALB
18	biliary atresia	30.2	GPT F2 ALB
19	felty syndrome	30.2	U2AF1 CSF3 CSF2
20	toxic shock syndrome	30.1	TLR4 SERPINC1 CSF3
21	beta-thalassemia	30.1	SERPINC1 GPT F2 EPO
22	splenic abscess	30.1	THPO GPT F2 CD4 ALB
23	portal hypertension	30.1	THPO PKHD1 GPT F2 ALB AFP
24	miliary tuberculosis	30.0	GPT CD4 ALB
25	aphthous stomatitis	30.0	CSF3 CD4 ALB
26	dysentery	30.0	TLR4 CD4 ALB
27	cavernous hemangioma	30.0	SERPINC1 F2 ALB AFP
28	klippel-trenaunay-weber syndrome	30.0	SERPINC1 PIK3R1 F2
29	portal vein thrombosis	29.9	THPO SERPINC1 GPT F2 ALB AFP
30	splenic sequestration	29.9	U2AF1 THPO F2 EPO CD4 ALB
31	peripheral vascular disease	29.9	SERPINC1 F2 EPO ALB
32	crohn's disease	29.9	TLR4 FOXP3 CSF2 CD4 ALB
33	myelofibrosis	29.9	U2AF1 THPO IL2RA EPO CSF3
34	sleep apnea	29.9	GPT EPO ALB
35	acquired immunodeficiency syndrome	29.9	IL2RA EPO CSF2 CD4 ALB
36	adult t-cell leukemia/lymphoma	29.8	IL2RA FOXP3 CD4
37	volvulus of midgut	29.8	GPT F2 ALB
38	choledocholithiasis	29.8	GPT F2 ALB
39	beta-thalassemia major	29.8	GPT EPO ALB
40	lymphoma, non-hodgkin, familial	29.7	U2AF1 IL2RA CSF3 CSF2 CD4
41	disseminated intravascular coagulation	29.7	SERPINC1 GPT F2
42	cholangitis	29.7	TLR4 GPT F2 ALB
43	syphilis	29.6	GPT FOXP3 CD4 ALB
44	neutropenia	29.6	TLR4 THPO GPT EPO CSF3 CSF2
45	systemic mastocytosis	29.6	U2AF1 PIK3R1 IL2RA
46	autoimmune hepatitis	29.6	GPT FOXP3 F2 ALB
47	lymphoma, hodgkin, classic	29.6	REL IL2RA CSF3 CSF2
48	hepatitis b	29.6	TLR4 GPT F2 ALB AFP
49	hemoglobinuria	29.6	THPO SERPINC1 F2 EPO CSF3
50	cystic fibrosis	29.6	TLR4 EGF CSF3 CSF2 CD4 ALB

Comorbidity relations with Hypersplenism via Phenotypic Disease Network (PDN): (show all 12)

Acquired Thrombocytopenia	Active Peptic Ulcer Disease
Acute Cystitis	Alcoholic Liver Cirrhosis
Chronic Congestive Splenomegaly	Deficiency Anemia
Heart Disease	Hepatic Encephalopathy
Iron Deficiency Anemia	Neutropenia
Portal Hypertension	Primary Thrombocytopenia

Graphical network of the top 20 diseases related to Hypersplenism:

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Symptoms & Phenotypes for Hypersplenism

GenomeRNAi Phenotypes related to Hypersplenism according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.14	AFP ALB CD4 CSF2 CSF3 EGF
2	no effect	GR00402-S-2	10.14	ALB CD4 CSF2 CSF3 EGF EPO
3	Reduced mammosphere formation	GR00396-S	9.5	AFP ALB CSF3 IL2RA PIK3R1 SERPINC1

MGI Mouse Phenotypes related to Hypersplenism:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.35	AFP ALB CD4 CSF2 EPO F2
2	immune system	MP:0005387	10.28	ALB CD4 CSF2 CSF3 EGF EPO
3	endocrine/exocrine gland	MP:0005379	10.23	AFP ALB CD4 CSF2 EGF F2
4	cellular	MP:0005384	10.22	ALB CD4 CSF2 EPO F2 FOXP3
5	normal	MP:0002873	10.21	ALB EGF F2 FOXP3 IL7R PIK3R1
6	liver/biliary system	MP:0005370	10.19	AFP ALB EPO FOXP3 PIK3R1 PKHD1
7	cardiovascular system	MP:0005385	10.18	ALB CSF2 EPO F2 FOXP3 IL2RA
8	digestive/alimentary	MP:0005381	10.13	ALB CD4 EGF F2 FOXP3 IL2RA
9	neoplasm	MP:0002006	10.07	AFP ALB CSF2 IL7R PIK3R1 TLR4
10	hematopoietic system	MP:0005397	10.06	CD4 CSF2 CSF3 EPO F2 FOXP3
11	respiratory system	MP:0005388	9.96	CSF2 EPO F2 FOXP3 IL2RA PKHD1
12	mortality/aging	MP:0010768	9.8	ALB CD4 CSF2 EPO F2 FOXP3
13	integument	MP:0010771	9.36	CD4 CSF2 CSF3 EGF F2 FOXP3

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Drugs & Therapeutics for Hypersplenism

Drugs for Hypersplenism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Warfarin

Approved

Phase 4

81-81-2, 129-06-6

54678486

Acetylsalicylic acid

Approved, Vet_approved

Phase 4

50-78-2

2244

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 4

1401-55-4

16129878 16129778

Dipyridamole

Approved

Phase 4

58-32-2

3108

Nadroparin

Approved, Investigational

Phase 4

Reviparin

Approved, Investigational

Phase 4

9041-08-1

Liver Extracts

Phase 4

Analgesics

Phase 4

Antirheumatic Agents

Phase 4

Fibrinolytic Agents

Phase 4

Antipyretics

Phase 4

Phosphodiesterase Inhibitors

Phase 4

Vasodilator Agents

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Platelet Aggregation Inhibitors

Phase 4

Calcium, Dietary

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Anticoagulants

Phase 4

Analgesics, Non-Narcotic

Phase 4

Anti-Inflammatory Agents

Phase 4

Heparin, Low-Molecular-Weight

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Valproic acid

Approved, Investigational

Phase 1, Phase 2

99-66-1

3121

Neurotransmitter Agents

Phase 1, Phase 2

Psychotropic Drugs

Phase 1, Phase 2

Anticonvulsants

Phase 1, Phase 2

Propranolol

Approved, Investigational

318-98-9, 525-66-6

62882 4946

Heparin, bovine

Approved, Investigational, Withdrawn

9005-49-6

22833565 9812414 772

Verapamil

Approved

152-11-4, 52-53-9

2520

Nitroglycerin

Approved, Investigational

55-63-0

4510

Somatostatin

Approved, Investigational

38916-34-6, 51110-01-1

53481605 16129706

Carvedilol

Approved, Investigational

72956-09-3

2585

Calcium heparin

Anesthetics

Sclerosing Solutions

Adrenergic beta-Antagonists

Adrenergic Antagonists

Adrenergic Agents

Hormones

Hormone Antagonists

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy and Safety of Warfarin Anticoagulation for Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy	Unknown status	NCT02238444	Phase 4	Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
2	Pilot (Phase I-II) Study of Valproic Acid (Depakote) for the Treatment of the Autoimmune Lymphoproliferative Syndrome (ALPS)	Completed	NCT00605657	Phase 1, Phase 2	Valproic Acid
3	Comparative Study of Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism	Unknown status	NCT02261584
4	Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension: Prevalence, Pattern, Correlations, and Therapy	Unknown status	NCT03269877
5	Multicentric Retrospective Case Control Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis	Unknown status	NCT01201655
6	Partial Splenic Embolization Combined With Endoscopic Therapies and NSBB Decreases the Variceal Rebleeding Rate in Cirrhosis Patients With Hypersplenism: a Multicenter Randomized Controlled Trial	Completed	NCT02778425
7	Transfemoral Versus Transradial Partial Splenic Artery Embolization in Patients With Hypersplenism, a Randomized Controlled Trial	Completed	NCT05446116
8	EUS-guided Partial Splenic Embolization in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension	Recruiting	NCT04692805		cyanoacrylate glue
9	The Effects of Endoscopy Combined With Partial Splenic Artery Embolization in the Treatment of Cirrhosis With Esophageal and Gastric Varices Complicated With Hyperplenism or Splenomegaly:A Randomized Controlled Study.	Enrolling by invitation	NCT05055713

Search NIH Clinical Center for Hypersplenism

Cochrane evidence based reviews: hypersplenism

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Genetic Tests for Hypersplenism

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Anatomical Context for Hypersplenism

Organs/tissues related to Hypersplenism:

MalaCards : Spleen, Bone Marrow, Bone, Liver, Kidney, Myeloid, Pineal

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Publications for Hypersplenism

Articles related to Hypersplenism:

(show top 50) (show all 2231)

#	Title	Authors	PMID	Year
1	Partial splenic embolization as pretreatment for antiviral therapy in hepatitis C virus infection. ⁵³ ⁶²	Palsson B...Verbaan H	16215425	2005
2	Platelet count increase following phlebotomy in iron overloaded patients with liver cirrhosis. ⁵³ ⁶²	Franchini M	12911944	2003
3	Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. ⁵³ ⁶²	Sanjo A...Suzuki N	12753144	2003
4	Serum thrombopoietin levels are linked to liver function in untreated patients with hepatitis C virus-related chronic hepatitis. ⁵³ ⁶²	Giannini E...Testa R	12399221	2002
5	Role of plasma thrombopoietin level in thrombocytopenia of postoperative biliary atresia patients. ⁵³ ⁶²	Hasegawa T...Okada A	12149701	2002
6	Thrombopoietin levels in serum and liver tissue in patients with chronic viral hepatitis and hepatocellular carcinoma. ⁵³ ⁶²	Okubo M...Kawasaki H	11787473	2000
7	Thrombocytopenia associated with liver cirrhosis and hepatitis C viral infection: role of thrombopoietin. ⁵³ ⁶²	Espanol I...Pujol-Moix N	11100362	2000
8	Laparoscopic cholecystectomy for cholelithiasis in patients with liver cirrhosis. ⁵³ ⁶²	Ishikawa T...Nishiguchi Y	18493357	1995
9	Open Radiofrequency Ablation Combined with Splenectomy and Pericardial Devascularization vs. Liver Transplantation for Hepatocellular Carcinoma Patients with Portal Hypertension and Hypersplenism: A Case-Matched Comparative Study. ⁶²	Wang X...Xia F	36345736	2023
10	Early prevention and risk factors analysis of portal vein system thrombosis after laparoscopic splenectomy and pericardial devascularization. ⁶²	Li Y...Pan Y	35764840	2022
11	Covered Transjugular Intrahepatic Portosystemic Shunt Improves Hypersplenism-Associated Cytopenia in Cirrhosis. ⁶²	Bucsics T...Reiberger T	35301618	2022
12	Hypersplenism and thrombocytopenia after exposure to ustekinumab in a patient with Crohn's disease. ⁶²	Altuwaijri MA...Aljasser MJ	36229348	2022
13	Minimally invasive treatment of cirrhotic secondary hypersplenism with high-intensity focused ultrasound. ⁶²	Zhang X...He S	36450808	2022
14	Successful Steroid Treatment of Pembrolizumab-induced Agranulocytosis that Developed after Splenectomy in a Patient with Non-small-cell Lung Cancer: A Case Report. ⁶²	Okuzumi S...Fukunaga K	36450461	2022
15	Primary splenic T-cell/histiocyte-rich B-cell lymphoma in a patient with recurrent hairy cell leukemia: a case report. ⁶²	Ahmad TY...Addeen SZ	36447474	2022
16	Non-alcoholic fatty liver disease and thrombocytopenia IV: its association with granulocytopenia. ⁶²	Rivera-Alvarez M...Ruiz-Arguelles GJ	34312112	2022
17	MPN-352 Clinicopathologic and Molecular Correlates of Organ Damage Across the Spectrum of Advanced Systemic Mastocytosis. ⁶²	Liang E...Gotlib J	36164002	2022
18	Hypersplenism caused by Caroli's disease. ⁶²	Liu C...Cui Z	36253263	2022
19	Robotic-assisted versus laparoscopic approach of Bai-Jiang-style vagus nerve-preserving splenectomy and azygoportal disconnection. ⁶²	Bai DS...Jiang GQ	34994944	2022
20	Clinical effects of cluster technology optimization and innovations on laparoscopic splenectomy and azygoportal disconnection: a single-center retrospective study with 500 consecutive cases. ⁶²	Wu LF...Jiang GQ	35257212	2022
21	Successful Preoperative Partial Splenic Artery and Aneurysm Embolization for Thrombocytopenia Associated with Failed Fontan Circulation. ⁶²	Sumitomo NF...Yamagishi H	36104230	2022
22	Vagus Nerve-Preserving Laparoscopic Splenectomy and Azygoportal Disconnection with Versus Without Intraoperative Endoscopic Variceal Ligation: a Randomized Clinical Trial. ⁶²	Bai DS...Jiang GQ	35676457	2022
23	Splenic artery aneurysm with extrahepatic portal venous obstruction: A case report. ⁶²	Pathak N...Lakhey PJ	36380538	2022
24	Early post-liver transplant thrombocytopenia in children: Clinical characteristics and significance. ⁶²	Tal N...Weissbach A	35599548	2022
25	Efficacy and safety of splenic artery embolization for intractable ascites using Amplatzer vascular plug versus coil after living donor liver transplantation. ⁶²	Lee CY...Ou HY	36218150	2022
26	Determination of etiology in patients admitted due to isolated leukopenia. ⁶²	Mart G...Buyukasik Y	35984149	2022
27	The prevalence of sickling abnormality in Oman: A review of relevant publications ⁶²	Al-Mashaikhi N...Khater D	36043956	2022
28	Comparison of thrombocytopenia between patients with non-alcoholic fatty liver disease and those with hepatitis C virus-related chronic liver disease. ⁶²	Kinoshita N...Okanoue T	35543116	2022
29	Management of Patients with Alagille Syndrome Undergoing Living Donor Liver Transplantation: A Report of 2 Cases. ⁶²	Alqahtani OJ...Alrashid AD	35921256	2022
30	Efficacy of interventional radiology in the management of portal hypertension: A narrative review. ⁶²	Ishikawa T	35984127	2022
31	Predicting the risk of postsplenectomy thrombosis in patients with portal hypertension using computational hemodynamics models: A proof-of-concept study. ⁶²	Wang T...Zhou Z	35834965	2022
32	Development of an Eye-Tracking Image Manipulation System for Angiography: A Comparative Study. ⁶²	Sato M...Ogura T	33158704	2022
33	Cystic fibrosis-related liver disease is an independent risk factor for mortality and increased health care resource utilization in hospitalized pediatric patients with cystic fibrosis. ⁶²	Thavamani A...Sankararaman S	35499220	2022
34	Improvement of SLC29A3 spectrum disorder-related sensorineural hearing loss after initiation of IL-6 inhibitor. ⁶²	Gunderman LM...Khojah A	35732371	2022
35	Clinico-pathological profile of pancytopenia patients in a single health care centre of northern India. ⁶²	Bhushan D...Agarwal M	36119319	2022
36	Partial splenectomy in children undergoing liver transplantation or venous shunt for severe hypersplenism: A case control comparative study. ⁶²	Boillot O...Dumortier J	35462062	2022
37	Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation. ⁶²	Kain V...Halade GV	34932185	2022
38	Porto-Sinusoidal Vascular Disease: A Pediatric Study of 30 Patients. ⁶²	Girard C...Broue P	35258501	2022
39	An updated meta-analysis of partial splenic embolization versus splenectomy in the treatment of hypersplenism due to cirrhosis. ⁶²	Huang Y...Xu X	34106805	2022
40	Primary splenic lymphoma discovered on massive splenomegaly: A case report. ⁶²	Beji H...Touinsi H	35658295	2022
41	[Clinical characteristics of 500 hospitalized patients with liver cirrhosis: a retrospective analysis from a tertiary hospital in Beijing]. ⁶²	Xu JH...Yu YY	35764547	2022
42	Successful use of a mesocaval shunt to treat refractory ascites in a chronic pancreatitis induced portal vein thrombosis. ⁶²	Dutta S...Ramakrishnaiah VPN	35193995	2022
43	Gastro-colic Fistula-associated Hypersplenism Causes Pancytopenia in a Patient with Crohn's Disease: A Case Report. ⁶²	Saito S...Fujiya M	35598997	2022
44	Spectrum of Pancytopenia in Adults Attending a Clinical Hematology Department: A Four-Year Experience From a Tertiary Care Center of Western India. ⁶²	Patel GR...Prajapati GR	35706755	2022
45	Elective splenectomy in patients with non-Hodgkin lymphoma: Does the size of the spleen affect surgical outcomes? ⁶²	Di Mauro D...Manzelli A	35168206	2022
46	Clinical and Haematological Abnormalities in Decompensated Chronic Liver Disease Patients. ⁶²	Lahari J...Shukla AK	35443528	2022
47	Limits in Laparoscopic Partial Splenectomy in Children. ⁶²	Tomuschat C...Reinshagen K	35626782	2022
48	National Consensus on Portal Hypertension Management in Indonesia. ⁶²	Kurniawan J...Hasan I	35818657	2022
49	Portal Steal Syndrome From a Large Linton's Splenorenal Shunt after Liver Transplantation: Successful Endovascular Management Through Off-Label Application of a 30 mm Amplatzer Cardiac Plug. ⁶²	Centonze L...De Carlis L	34978227	2022
50	Splenectomy ameliorates portal pressure and anemia in animal models of cirrhotic and non-cirrhotic portal hypertension. ⁶²	Schwabl P...Reiberger T	35272246	2022

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Genes for Hypersplenism

Genes related to Hypersplenism (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	F2	Coagulation Factor II, Thrombin	Protein Coding	20.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18493357
2	THPO	Thrombopoietin	Protein Coding	15.37	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12149701 12399221 12753144 (more) 11100362 11787473 12911944 16215425
3	ALB	Albumin	Protein Coding	14.66	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	EPO	Erythropoietin	Protein Coding	13.34	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	SERPINC1	Serpin Family C Member 1	Protein Coding	12.89	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	CD4	CD4 Molecule	Protein Coding	12.84	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	CSF3	Colony Stimulating Factor 3	Protein Coding	12.8	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	CSF2	Colony Stimulating Factor 2	Protein Coding	11.36	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	TLR4	Toll Like Receptor 4	Protein Coding	11.22	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	FOXP3	Forkhead Box P3	Protein Coding	11.01	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	10.69	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	EGF	Epidermal Growth Factor	Protein Coding	10.26	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	10.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	IL7R	Interleukin 7 Receptor	Protein Coding	10.09	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	7.3	GeneCards inferred via : Publications (show sections)
16	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	7.3	GeneCards inferred via : Publications (show sections)
17	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	6.83	DISEASES inferred ¹⁴ ¹⁴
18	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.62	DISEASES inferred ¹⁴
19	AFP	Alpha Fetoprotein	Protein Coding	6.12	DISEASES inferred ¹⁴
20	PKHD1	PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin	Protein Coding	5.95	DISEASES inferred ¹⁴
21	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.94	DISEASES inferred ¹⁴

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Variations for Hypersplenism

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Expression for Hypersplenism

Search GEO for disease gene expression data for Hypersplenism.

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Pathways for Hypersplenism

Pathways related to Hypersplenism according to GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.52	THPO PIK3R1 IL7R IL2RA F2 EPO
2	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.41	TLR4 RELA PIK3R1 IL7R IL2RA F2
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.28	RELA PIK3R1 IL7R IL2RA CSF3 CSF2
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.17	TLR4 THPO PIK3R1 IL7R IL2RA EGF
5	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.16	THPO PIK3R1 IL7R IL2RA EGF CSF3
6	IL-9 Signaling Pathways ⁶⁵ Show member pathways Adipocytokines and Insulin Signaling ⁶⁵ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Pathway ⁶⁴ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ Immune response IL-9 signaling pathway ²² Interleukin-9 signaling ⁶⁶	12.85	THPO RELA PIK3R1 IL7R IL2RA
7	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.63	RELA REL PIK3R1 EGF CD4
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.57	THPO PIK3R1 IL7R IL2RA EPO EGF
9	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.56	TLR4 RELA PIK3R1 IL7R IL2RA EPO
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.53	CD4 F2 PIK3R1 REL RELA
11	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.53	TLR4 THPO RELA REL PIK3R1 EGF
12	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.48	EGF PIK3R1 REL RELA
13	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.4	TLR4 RELA REL PIK3R1
14	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	12.35	SERPINC1 F2 ALB AFP
15	B Cell Receptor Signaling Pathway ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.29	CD4 PIK3R1 REL RELA
16	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.24	RELA REL CSF3 CSF2
17	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.1	RELA PIK3R1 CSF2 CD4
18	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.08	RELA REL PIK3R1 EGF
19	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	12.01	THPO EGF ALB AFP
20	Ebola virus infection in host ⁷⁴	11.99	TLR4 RELA REL PIK3R1
21	IL2 signaling events mediated by STAT5 ⁶¹ Show member pathways IL2 signaling events mediated by PI3K ⁶¹ IL2-mediated signaling events ⁶¹ Interleukin-2 signaling ⁶⁶	11.94	FOXP3 IL2RA PIK3R1 RELA
22	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.93	IL2RA PIK3R1 RELA TLR4
23	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.86	RELA REL IL2RA CD4
24	Innate Lymphoid Cells Differentiation ⁶⁵	11.78	IL7R IL2RA CD4
25	Glucocorticoid receptor regulatory network ⁶¹	11.76	RELA CSF2 AFP
26	Acute viral myocarditis ⁷⁴	11.75	TLR4 PIK3R1 CD4
27	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.73	IL7R CSF2 CD4
28	Th17 cell differentiation pathway ⁷⁴	11.7	IL2RA FOXP3 CD4
29	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.68	IL2RA FOXP3 CSF2
30	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.64	RELA REL CSF2
31	Lung fibrosis ⁷⁴	11.64	EGF CSF3 CSF2
32	miRNAs involvement in the immune response in sepsis ⁷⁴	11.63	TLR4 RELA REL
33	NF-kB (NFkB) Pathway ⁶⁷	11.57	TLR4 RELA CD4
34	SHP2 signaling ⁶¹	11.56	EGF IL2RA PIK3R1
35	Transcription_NF-kB signaling pathway ²²	11.55	REL RELA TLR4
36	IL-2 Gene Expression in Activated and Quiescent T-Cells ⁶⁴ Show member pathways TOB in T-Cell Signaling ⁶⁴	11.53	RELA REL PIK3R1 EGF
37	Th2 Differentiation ⁶⁵	11.48	IL2RA FOXP3 CD4
38	THC Differentiation Pathway ⁶⁴	11.47	RELA REL IL2RA CD4
39	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	11.44	F2 ALB AFP
40	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.43	TLR4 RELA REL
41	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.4	TLR4 RELA REL FOXP3 CSF3 CSF2
42	IL 10 signaling pathway ⁶⁷	11.35	TLR4 RELA REL PIK3R1
43	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.33	IL2RA FOXP3 CSF2
44	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.23	THPO IL7R IL2RA EPO CSF3 CSF2
45	Cytokines and inflammatory response ⁷⁴	11.16	CSF3 CSF2 CD4
46	Telomere Extension by Telomerase ⁶⁴ Show member pathways XAV939 stabilizes AXIN ⁶⁶	11.08	IL2RA PIK3R1 REL RELA
47	G-protein signaling_Rap2B regulation pathway ²²	11.01	THPO PIK3R1 EGF CSF3 CSF2
48	LDL- influence on CD14 and TLR4 ⁷⁴	10.98	TLR4 RELA REL
49	Neuroinflammation ⁷⁴	10.75	TLR4 RELA
50	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) ⁶⁶	10.7	IL2RA FOXP3

Sources

GO Terms for Hypersplenism

Cellular components related to Hypersplenism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.36	TLR4 PKHD1 IL7R IL2RA F2 CD4
2	NF-kappaB complex	GO:0071159	9.26	RELA REL

Biological processes related to Hypersplenism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10	CD4 CSF2 CSF3 IL2RA IL7R PIK3R1
2	cellular response to lipopolysaccharide	GO:0071222	9.96	TLR4 THPO RELA CSF3 CSF2
3	T cell differentiation	GO:0030217	9.8	PIK3R1 IL7R CD4
4	T cell homeostasis	GO:0043029	9.77	IL7R IL2RA FOXP3
5	positive regulation of cell population proliferation	GO:0008284	9.58	THPO RELA PKHD1 IL7R F2 EPO
6	negative regulation of lymphocyte proliferation	GO:0050672	9.43	IL2RA FOXP3
7	negative regulation of macromolecule metabolic process	GO:0010605	9.32	RELA REL
8	lymphocyte proliferation	GO:0046651	9.13	TLR4 IL2RA FOXP3