Hypertension, Diastolic disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP540 MIFTS: 37	Hypertension, Diastolic Categories: Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Hypertension, Diastolic

MalaCards integrated aliases for Hypertension, Diastolic:

Name: Hypertension, Diastolic ⁵⁷

Hypertension, Diastolic, Resistance to ⁵⁷ ²⁹ ¹³ ⁶ ³⁹

Diastolic Hypertension ⁵⁴ ⁷¹

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Inheritance:
autosomal dominant

HPO:

³¹

hypertension, diastolic:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 608622

MedGen ⁴¹ C1837739

SNOMED-CT via HPO ⁶⁸ 263681008

UMLS ⁷¹ C0235222

Sources

Summaries for Hypertension, Diastolic

OMIM® : ⁵⁷ Hypertension is a significant risk factor for cardiac and renal disease, arteriosclerosis, retinopathy, and stroke. Systolic hypertension reflects an increase in the force of cardiac contraction, whereas diastolic hypertension reflects an increase in peripheral vascular resistance. Normalization of blood pressure is associated with reductions in morbidity and mortality related to end-organ damage. (608622) (Updated 05-Mar-2021)

MalaCards based summary : Hypertension, Diastolic, also known as hypertension, diastolic, resistance to, is related to proteinuria, chronic benign and renovascular hypertension. An important gene associated with Hypertension, Diastolic is KCNMB1 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1), and among its related pathways/superpathways are ACE Inhibitor Pathway, Pharmacodynamics and Renin secretion. The drugs Nebivolol and Lisinopril have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial, and related phenotypes are elevated diastolic blood pressure and renal/urinary system

Sources

Related Diseases for Hypertension, Diastolic

Diseases related to Hypertension, Diastolic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)

#	Related Disease	Score	Top Affiliating Genes
1	proteinuria, chronic benign	29.7	REN ACE
2	renovascular hypertension	29.7	REN ACE
3	carotid stenosis	29.7	REN ACE
4	cardiac arrest	29.4	REN ACE
5	hypertension, essential	28.7	REN KCNMB1 KCNMA1 ACE
6	congestive heart failure	10.1
7	hepatic tuberculosis	10.1	GGT1 ACE
8	hypoaldosteronism	10.0	REN ACE
9	renal artery obstruction	10.0	REN ACE
10	orthostatic proteinuria	10.0	REN ACE
11	cholesterol embolism	10.0	REN ACE
12	hypertensive encephalopathy	10.0	REN ACE
13	kidney papillary necrosis	10.0	REN ACE
14	generalized atherosclerosis	10.0	REN ACE
15	potter's syndrome	10.0	REN ACE
16	severe nonproliferative diabetic retinopathy	10.0	REN ACE
17	perinephritis	10.0	REN ACE
18	pulmonary valve insufficiency	10.0	REN ACE
19	hypertensive retinopathy	10.0	REN ACE
20	kidney hypertrophy	10.0	REN ACE
21	constrictive pericarditis	10.0	REN ACE
22	fibromuscular dysplasia	10.0	REN ACE
23	renal artery disease	10.0	REN ACE
24	pure autonomic failure	10.0	REN ACE
25	inappropriate adh syndrome	10.0	REN ACE
26	left bundle branch hemiblock	10.0	REN ACE
27	cardiac tamponade	10.0	REN ACE
28	chronic pyelonephritis	10.0	REN ACE
29	coronary artery vasospasm	10.0	REN ACE
30	central sleep apnea	10.0	REN ACE
31	sleep apnea	10.0	REN ACE
32	anuria	10.0	REN ACE
33	alcoholic cardiomyopathy	10.0	REN ACE
34	diabetic autonomic neuropathy	10.0	REN ACE
35	tricuspid valve disease	10.0	REN ACE
36	tricuspid valve insufficiency	10.0	REN ACE
37	pseudohyperkalemia, familial, 2, due to red cell leak	10.0	REN ACE
38	aortic valve insufficiency	10.0	REN ACE
39	pyelitis	10.0	REN ACE
40	mitral valve stenosis	10.0	REN ACE
41	acute kidney tubular necrosis	10.0	REN ACE
42	microvascular complications of diabetes 3	10.0	REN ACE
43	mitral valve insufficiency	10.0	REN ACE
44	vascular disease	10.0
45	pericardium disease	10.0	REN ACE
46	hepatorenal syndrome	10.0	REN ACE
47	autonomic nervous system disease	10.0	REN ACE
48	renal tubular dysgenesis	10.0	REN ACE
49	malignant hypertension	10.0	REN ACE
50	diastolic heart failure	10.0	REN ACE

Graphical network of the top 20 diseases related to Hypertension, Diastolic:

Sources

Symptoms & Phenotypes for Hypertension, Diastolic

Human phenotypes related to Hypertension, Diastolic:

³¹

#	Description	HPO Frequency	HPO Source Accession
1	elevated diastolic blood pressure ³¹		HP:0005117

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Cardiovascular Vascular:
resistance to moderate and severe diastolic hypertension

Clinical features from OMIM®:

608622 (Updated 05-Mar-2021)

MGI Mouse Phenotypes related to Hypertension, Diastolic:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	9.02	ACE GGT1 KCNMA1 KCNMB1 REN

Sources

Drugs & Therapeutics for Hypertension, Diastolic

Drugs for Hypertension, Diastolic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Nebivolol

Approved, Investigational

Phase 4

152520-56-4, 118457-14-0, 99200-09-6

71301

Synonyms:

1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol

1,1'-[Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol

1,1'-Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2'-iminodiethanol

104365-59-5

118457-14-0

2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]

99200-09-6

a,Alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

AC-1611

AC1L2FX8

AC1Q4OMF

alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol

alpha,Alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol

alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

alpha,Alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

alpha,alpha'-(Iminodimethylene)bis(6-fluoro-2-chromanmethanol)

Bystolic

C22H25F2NO4

CHEMBL434394

CID71301

D05127

DB04861

Hydrochloride, nebivolol

I06-0378

L001284

Lobivon

LS-178404

MolPort-003-849-343

Narbivolol

Nebicard-5

Nebilet

Nebilong

Nebipill

Nebivolol

Nebivolol (USAN/INN)

Nebivolol [USAN:INN:BAN]

Nebivolol hydrochloride

Nebivololum

nebivololum [latin]

Nebivololum [Latin]

Nodon

Nubeta

PDSP1_000244

PDSP2_000243

PI-21858

R 67555

R65,824

R-67555

Silostar

UNII-030Y90569U

Α,alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

Lisinopril

Approved, Investigational

Phase 4

83915-83-7, 76547-98-3

5362119

Synonyms:

(2S)-1-[(2S)-6-amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid

(S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline

(S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline

(S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline

(S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline

[N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline

[N2-[(S)-1-CARBOXY-3-phenylpropyl]-L-lysyl-L-proline

[N2-[(S)-1-CARBOXY-3-PHENYLPROPYL]-L-LYSYL-L-PROLINE

1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline

1-[Nalpha-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-proline

76547-98-3

77726-95-5

83915-83-7 (Parent)

AC1NSFPF

Acerbon

Acercomp

Alapril

BB_NC-1454

BIDD:GT0755

BPBio1_000290

BRD-K67966701-335-03-5

BRN 4276619

BSPBio_000262

C21H31N3O5

Carace

CCRIS 3568

CHEBI:43755

CHEMBL1237

CID5362119

Cipral

Cipril

Coric

D08131

DB00722

DivK1c_001037

Doneka

EINECS 278-488-1

HMS1921B14

HMS2090O14

HMS2092L21

HMS503O15

I06-1895

ICI-209K

IDI1_001037

Inhibril

Inopril

KBio1_001037

KBio2_000977

KBio2_003545

KBio2_006113

KBio3_002002

KBioGR_001599

KBioSS_000977

L0220

Linopril

Linvas

Lipril

Lisinal

lisinopril

Lisinopril

Lisinopril (anhydrous)

Lisinopril (INN)

Lisinopril anhydrous

Lisinopril Dihydrate

Lisinopril maleate (1:1)

Lisinopril sulfate (1:2)

Lisinoprilum

Lisinoprilum [Latin]

Lisipril

Lisoril

Lispril

Longes

Loril

LPR

LS-118899

Lysinopril

MK 521

MK 522

MK-521

MLS001306436

MLS001306481

MolPort-002-507-428

N-(1(S)-Carboxy-3-phenylpropyl)-L-lysyl-L-proline

N(2)-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline

N2-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl-L-proline

N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline

NCGC00179623-01

NINDS_001037

Noperten

Novatec

Presiten

Prestwick0_000301

Prestwick1_000301

Prestwick2_000301

Prestwick3_000301

Prinil

Prinivil

Prinzide

Renacor

Sinopril

Sinopryl

SMR000544473

SPBio_001351

SPBio_002481

Spectrum_000497

SPECTRUM1501217

Spectrum2_001456

Spectrum3_000941

Spectrum4_001040

Spectrum5_000995

Tensopril

Tensyn

Tersif

TL8005499

Vivatec

Zestoretic

Zestril

Zestril (TN)

Protective Agents

Phase 4

Cardiotonic Agents

Phase 4

Adrenergic beta-Agonists

Phase 4

Neurotransmitter Agents

Phase 4

Antihypertensive Agents

Phase 4

Angiotensin-Converting Enzyme Inhibitors

Phase 4

HIV Protease Inhibitors

Phase 4

Adrenergic Agents

Phase 4

protease inhibitors

Phase 4

Adrenergic Agonists

Phase 4

Vasodilator Agents

Phase 4

Telmisartan

Approved, Investigational

144701-48-4

65999

Synonyms:

144701-48-4

2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid

4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylate

4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

4'-((4-mehtyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimmidazolyl)methyl)-2-biphenylcarboxylic acid

4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylate

4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid

4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid

4'-[(1,4'-Dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylate

4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid

4'-[(1,4'-Dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid

4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid

4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylate

4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid

4'-[(1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid

Abbott brand of telmisartan

AC1L24EB

AC1Q5U7O

AC-2013

Bay 68-9291

BAY68-9291

BAY-68-9291

BIBR 277

BIBR 277Se

BIBR 277SE

BIBR-277

BIBR-277SE

BIBR-277-SE

BIDD:GT0365

Bio-0103

Boehringer Ingelheim brand of telmisartan

BRD-K73999723-001-02-2

BSPBio_002738

C07710

C084178

C33H30N4O2

CHEBI:9434

CHEMBL1017

CID65999

CPD000466326

D00627

DB00966

Glaxo Wellcome brand of telmisartan

GlaxoSmithKline brand of telmisartan

HMS1922P07

HMS2051P16

HMS2090P17

HMS2093M22

HSDB 7590

I06-0281

KBio3_001958

KBioGR_001842

Kinzal

Kinzalmono

L001035

LS-44263

Micardis

Micardis (TN)

Micardis HCT

Micardis, Targit, Temax, BIBR277, Telmisartan

MLS000759432

MLS001076687

MolPort-003-666-621

NCGC00095150-01

NCGC00095150-02

NCGC00095150-03

Pritor

S1738_Selleck

SAM001246602

SMR000466326

SPBio_002131

SPECTRUM1505261

Spectrum2_001976

Spectrum3_001089

Spectrum4_001261

Spectrum5_001053

STK624049

telmisartan

Telmisartan

Telmisartan (JAN/USAN/INN)

Telmisartan [USAN:INN]

Telmisartan tablets

TL8000991

UNII-U5SYW473RQ

YM-086

Angiotensin II

Approved, Investigational

68521-88-0, 4474-91-3, 11128-99-7

172198

Synonyms:

1-8-Angiotensin I

1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide

5 L Isoleucine angiotensin II

5-isoleucine-angiotensin II

5-Isoleucine-angiotensin II

5-L-Isoleucine angiotensin II

5-L-isoleucineangiotensin II

5-L-Isoleucineangiotensin II

Ang II

ANG-(1-8)octapeptide

Angiotensin

Angiotensin 2

Angiotensin II

Angiotensin II (human)

Angiotensin II (mouse)

Angiotensin II, 5-L-isoleucine

Angiotensin-(1-8) octapeptide

Angiotonin

Asp-arg-val-tyr-ile-his-pro-phe

Delivert

Human angiotensin II

Hypertensin

II, 5-L-isoleucine angiotensin

Ile(5)-angiotensin II

Ile5-angiotensin II

Isoleucine(5)-angiotensin

Isoleucine(5)-angiotensin II

isoleucine5-angiotensin II

Isoleucyl(5)-angiotensin II

N-(1-(N-(N-(N-(N-(N(2)-L-a-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

N-(1-(N-(N-(N-(N-(N(2)-L-alpha-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

N-(1-(N-(N-(N-(N-(N(2)-L-Α-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

Valyl(5)-angiotensin II

Hydrochlorothiazide

Approved, Vet_approved

58-93-5

3639

Synonyms:

125727-50-6

3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi

3,4-Dihydrochlorothiazide

58-93-5

6-Chloro-7-sulfamoyl-3, 4-dihy

8049-49-8

AB00052012

AC-11072

AC1L1GDT

AC1Q55FM

Acesistem

Acuilix

Acuretic

adiazine-1,1-dioxide

AF-614/30832002

AKOS000121373

Aldactazide

Aldactazide 25/25

Aldazida

Aldectazide 50/50

Aldoril

Ambap58-93-5

Apo-Hydro

Apresazide

Aquarills

Aquarius

Aquazide H

Aquazide-H

ARONIS24316

BAS 00371709

BIDD:GT0153

Bio-0714

BPBio1_000019

BRD-K13078532-001-05-2

Bremil

Briazide

BRN 0625101

BSPBio_000017

BSPBio_002132

C7H8ClN3O4S2

Caplaril

Capozide

Carozide

CAS-58-93-5

Catiazida

CCRIS 2082

CHEMBL435

Chlorizide

Chlorosulthiadil

Chlorothiazide

Chlorsulfonamidodihydrobenzothiadiazine dioxide

Chlorzide

Chlothia

CID3639

Cidrex

Clorana

component of Aldactazide

component of Aldoril

Component of Butizide Prestabs

component of Caplaril

component of Cyclex

component of Dyazide

component of Esimil

Concor Plus

Condiuren

CPD000035778

D00340

D006852

DB00999

Diaqua

Dichlorosal

Dichlorotride

Dichlothiazide

Dichlotiazid

Dichlotride

diclot ride

Diclotride

Dicyclotride

Didral

Dihydran

Dihydrochlorothiazid

Dihydrochlorothiazide

Dihydrochlorothiazidum

Dihydrochlorurit

Dihydrochlorurite

Dihydroxychlorothiazidum

Direma

Disalunil

Disothiazid

Diu 25 Vigt

Diu-melusin

Diu-Melusin

Diuril

Diurogen

DivK1c_000289

Dixidrasi

Drenol

dro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Dyazide

EINECS 200-403-3

Esidrex

Esidrix

Esidrix (TN)

Esimil

Esoidrina

EU-0100614

Fluvin

FT-0082750

H 4759

H1274

H2910_SIAL

H4759_SIAL

HCT

HCT-Isis

HCTZ

HCZ

Hidril

Hidrochlortiazid

Hidroclorotiazida

Hidroclorotiazida [INN-Spanish]

Hidro-Niagrin

Hidroronol

Hidrosaluretil

Hidrotiazida

HMS1568A19

HMS1920D19

HMS2091L05

HMS500O11

HMS553N04

HSDB 3096

Hyclosid

Hydrex-semi

Hydril

Hydro Par

Hydro-aquil

Hydro-Aquil

Hydro-chlor

Hydrochlorat

Hydrochloro thiazide

Hydrochlorot

Hydrochlorothiazid

hydrochlorothiazide

Hydrochlorothiazide

Hydrochlorothiazide (JP15/USP/INN)

Hydrochlorothiazide [INN:BAN:JAN]

Hydrochlorothiazide intensol

Hydrochlorothiazide Intensol

Hydrochlorothiazidum

Hydrochlorothiazidum [INN-Latin]

Hydrochlorthiazide

Hydrochlorthiazidum

Hydrocot

Hydro-D

Hydrodiuretic

Hydrodiuril

Hydro-diuril

Hydro-Diuril

HydroDIURIL

Hydropres

Hydrosaluric

Hydro-Saluric

Hydro-T

Hydrothide

Hydrozide

Hydrozide Injection, Veterinary

Hypothiazid

Hypothiazide

Hytrid

Hyzaar

I09-0531

IDI1_000289

Idroclorotiazide

Idroclorotiazide [DCIT]

Idrotiazide

Inderide

Inderide 80/25

Indroclor

Ivaugan

Jen-diril

Jen-Diril

KBio1_000289

KBio2_001357

KBio2_003925

KBio2_006493

KBio3_001352

KBioGR_000351

KBioSS_001357

Lopac0_000614

Lopac-H-4759

Lopressor HCT

Lotensin Hct

Lotensin HCT

LS-243

Manuril

Maschitt

Maxzide

Maybridge Compound 10

Maybridge1_004336

Mazide 25 mg

Medozide

Megadiuril

Microzide

Microzide (TN)

Mictrin

Mikorten

MLS000069619

Modurcen

Moduretic

MolPort-000-144-465

Natrinax

NCGC00015508-01

NCGC00015508-02

NCGC00015508-03

NCGC00015508-07

NCGC00015508-12

NCGC00021906-03

NCGC00021906-04

NCGC00021906-05

NCGC00021906-06

NCGC00021906-07

NCGC00021906-08

NCI60_004317

NCI-C55925

Nefrix

Nefrol

Neo-codema

Neo-Codema

Neoflumen

Neo-Flumen

Neo-Minzil

Newtolide

NINDS_000289

Novodiurex

NSC 53477

NSC53477

Oprea1_357174

Oretic

Pantemon

Panurin

panurin dichloride

Prestwick_263

Prestwick0_000009

Prestwick1_000009

Prestwick2_000009

Prestwick3_000009

Prinzide

Raunova Plus

Ro-hydrazide

Ro-Hydrazide

Roxane

S1708_Selleck

Saldiuril

SAM002554901

Sectrazide

Selozide

Ser-ap-es

Servithiazid

SMR000035778

SPBio_001259

SPBio_001938

Spectrum_000877

SPECTRUM1500335

Spectrum2_001040

Spectrum3_000456

Spectrum4_000006

Spectrum5_000824

Spironazide

STK315354

Su 5879

Tandiur

Thiaretic

Thiuretic

Thlaretic

Timolide

Unazid

UNII-0J48LPH2TH

Unipres

Urodiazin

Urozide

Vaseretic

Vetidrex

WLN: T66 BSWM EM DHJ HG ISZW

Ziac

Zide

ZINC00896569

Giapreza

Angiotensin II Type 1 Receptor Blockers

Angiotensinogen

Sodium Chloride Symporter Inhibitors

diuretics

Angiotensin Receptor Antagonists

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized, Double-blind, Parallel-Group Study to Evaluate the Effects of First-Line Treatment With a Free Combination of Nebivolol and Lisinopril Compared With Placebo and the Monotherapy Components on Blood Pressure in Patients With Stage 2 Diastolic Hypertension	Completed	NCT01218100	Phase 4	nebivolol and lisinopril (free combination);nebivolol monotherapy;lisinopril monotherapy;placebo
2	Observational Study in Everyday Medical Practice of the Effectiveness of Telmisartan for Treatment of Isolated Systolic Hypertension in Comparison With Systolic/Diastolic Hypertension in Patients Aged 55 or Older	Completed	NCT02242877		Telmisartan;Telmisartan combined with hydrochlorothiazide

Search NIH Clinical Center for Hypertension, Diastolic

Sources

Genetic Tests for Hypertension, Diastolic

Genetic tests related to Hypertension, Diastolic:

#	Genetic test	Affiliating Genes
1	Hypertension, Diastolic, Resistance to ²⁹	KCNMB1

Sources

Anatomical Context for Hypertension, Diastolic

MalaCards organs/tissues related to Hypertension, Diastolic:

⁴⁰

Heart, Kidney, Endothelial

Sources

Publications for Hypertension, Diastolic

Articles related to Hypertension, Diastolic:

(show top 50) (show all 446)

#	Title	Authors	PMID	Year
1	Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. ⁵⁷ ⁶	Fernandez-Fernandez JM...Valverde MA	15057310	2004
2	E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients. ⁶	Via M...Moral P	16155733	2005
3	A longitudinal study on the relationship between shift work and the progression of hypertension in male Japanese workers. ⁵⁴ ⁶¹	Oishi M...Nogawa K	16269958	2005
4	Effects of perindopril on elastic and structural properties of large arteries in essential hypertension. ⁵⁴ ⁶¹	Lacourciere Y...Canadian Hypertension Society	15229761	2004
5	[The TEAM study--a study of the effectiveness and tolerance of treatment of essential hypertension with a fixed combination of trandolapril and verapamil]. ⁶¹ ⁵⁴	Widimsky J...Dzurik R	9820054	1998
6	Treatment of senile hypertension: the Fosinopril in Old Patients Study (FOPS). ⁶¹ ⁵⁴	Vetter W	9366282	1997
7	I/D polymorphism of the angiotensin-converting enzyme gene does not predict isolated systolic or systolic-diastolic hypertension in the elderly. ⁵⁴ ⁶¹	Johnson AG...MaCallum J	8733034	1996
8	Angiotensin converting enzyme inhibitors as initial monotherapy in severe hypertension. Quinapril and captopril. ⁶¹ ⁵⁴	Frishman WH...Greenberg S	1747216	1991
9	Hemodynamic and renin responses to nifedipine in renovascular hypertension. ⁵⁴ ⁶¹	Fiorentini C...Riva S	2405611	1990
10	Time-evolving coupling functions for evaluating the interaction between cerebral oxyhemoglobin and arterial blood pressure with hypertension. ⁶¹	Li W...Li Z	33253413	2020
11	A robust diving response in the laboratory mouse. ⁶¹	Hult EM...Swoap SJ	31552491	2019
12	Hypertension, diastolic stress test, and HFpEF: Does new scoring system change something? ⁶¹	Tadic M...Cuspidi C	31769582	2019
13	Microvascular decompression in patients with hemifacial spasm. ⁶¹	Niu X...Li W	31617334	2019
14	Prevalence of diabetes and cardio-metabolic risk factors in young men in the United Arab Emirates: A cross-sectional national survey. ⁶¹	Alzaabi A...Ahmed LA	31592445	2019
15	Hypertension and its risk factors among male adolescents in intermediate and secondary schools in Sakaka City, Aljouf Region of Saudi Arabia. ⁶¹	Bandy A...Aldawasri MM	31417059	2019
16	Ranolazine: Multifaceted Role beyond Coronary Artery Disease, a Recent Perspective. ⁶¹	Ghosh GC...Aneja A	31007857	2018
17	ASSOCIATION BETWEEN COMPONENTS OF METABOLIC SYNDROME AND COGNITIVE DYSFUNCTION: CROSS-SECTIONAL STUDY AMONG THE POPULATION OF THE TURKESTAN REGION. ⁶¹	Madenbay K...Sadykova K	29905556	2018
18	Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa. ⁶¹	Mokoli VM...Nseka NM	29554877	2018
19	Sex Differences in Heart Failure. ⁶¹	Savarese G...D'Amario D	30051405	2018
20	Anthropometric and cardiometabolic risk factors in parents and child obesity in Segamat, Malaysia. ⁶¹	Partap U...Reidpath DD	29106558	2017
21	Mid-term results of bilateral lung transplant with postoperatively extended intraoperative extracorporeal membrane oxygenation for severe pulmonary hypertension. ⁶¹	Salman J...Tudorache I	28329232	2017
22	Chronic obstructive pulmonary disease and atrial fibrillation: An unknown relationship. ⁶¹	Goudis CA	28188041	2017
23	Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina. ⁶¹	Banerjee K...Gupta A	27838121	2017
24	Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development. ⁶¹	Plotnikov MB...Arkhipov AM	28722518	2017
25	Global longitudinal strain predicts incident atrial fibrillation and stroke occurrence after acute myocardial infarction. ⁶¹	Olsen FJ...Biering-Sorensen T	27858918	2016
26	The Inter-rater Reliability of Echocardiographic Diastolic Function Evaluation Among Emergency Physician Sonographers. ⁶¹	Saul T...Suprun M	27614538	2016
27	Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology. ⁶¹	Bakeer N...Malik P	27503873	2016
28	A Randomized, Double-blind, Candesartan-controlled, Parallel Group Comparison Clinical Trial to Evaluate the Antihypertensive Efficacy and Safety of Fimasartan in Patients with Mild to Moderate Essential Hypertension. ⁶¹	Lee JH...Chae SC	27161546	2016
29	The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial. ⁶¹	Movahed A...Netticadan T	27339453	2016
30	Correlates of Blood Pressure According to Early, On Time, and Late Maturation in Adolescents. ⁶¹	Werneck AO...Cyrino ES	26408345	2016
31	[Hypertension Control at the Primary Health Care: A Comparison Among Portuguese Natives and Portuguese Speaking African Coutries Immigrants]. ⁶¹	Lopes E...Rocha E	27285095	2016
32	Valacyclovir and Acyclovir Neurotoxicity With Status Epilepticus. ⁶¹	Hoskote SS...Jones JP	24368610	2016
33	Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease. ⁶¹	Velkoska E...Burrell LM	27571511	2016
34	Pathophysiological effects of different risk factors for heart failure. ⁶¹	Yang H...Marwick TH	27042319	2016
35	Genotype Correlations With Blood Pressure and Efficacy From a Randomized Phase III Trial of Second-Line Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma. ⁶¹	Escudier B...Williams JA	25816720	2015
36	Antibodies against native and oxidized cardiolipin and phosphatidylserine and phosphorylcholine in atherosclerosis development. ⁶¹	Frostegard AG...Frostegard J	25473948	2014
37	Cardiac mechanics and ventricular twist by three-dimensional strain analysis in relation to B-type natriuretic peptide as a clinical prognosticator for heart failure patients. ⁶¹	Chang SN...Yeh HI	25545637	2014
38	Perceived racial discrimination and hypertension: a comprehensive systematic review. ⁶¹	Dolezsar CM...Miller SB	24417692	2014
39	Transarterial treatment of congenital renal arteriovenous fistulas. ⁶¹	Nassiri N...Rosen RJ	23810295	2013
40	Effects of add-on nebivolol on blood pressure and glucose parameters in hypertensive patients with prediabetes. ⁶¹	Deedwania P...Brener L	23551727	2013
41	Probable carvedilol-induced thrombocytopenia. ⁶¹	Alex S...Aggarwal A	23515512	2013
42	Blood pressure load in adults with treated hypertension. ⁶¹	Kluk MK...Wozakowska-Kaplon B	23633274	2013
43	Progression of myocardial remodeling and mechanical dysfunction in the spontaneously hypertensive rat. ⁶¹	LeGrice IJ...Smaill BH	23001837	2012
44	Analysis of various etiologies of hypertension in patients hospitalized in the endocrinology division. ⁶¹	Ye D...Li C	22212439	2012
45	Prediction of individuals prone to suffer from early onset of hypertension. ⁶¹	Sherpa MT...Pramanik T	23671955	2012
46	Aldosterone and the heart: from basic research to clinical evidence. ⁶¹	Catena C...Sechi LA	22095099	2012
47	Clinical and echocardiographic correlates of intra-atrial conduction delay. ⁶¹	Weijs B...Crijns HJ	21846646	2011
48	Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. ⁶¹	Neldam S...TEAMSTA-10 Investigators	21955225	2011
49	Telmisartan and amlodipine single-pill combinations vs amlodipine monotherapy for superior blood pressure lowering and improved tolerability in patients with uncontrolled hypertension: results of the TEAMSTA-5 study. ⁶¹	Neldam S...TEAMSTA-5 Investigators	21762357	2011
50	Increased serum S-100B and neuron specific enolase - Potential markers of early nervous system involvement in essential hypertension. ⁶¹	Gonzalez-Quevedo A...Menendez K	21130083	2011

Sources

Genes for Hypertension, Diastolic

Genes related to Hypertension, Diastolic (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	KCNMB1	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1	Protein Coding	682.03	Molecular basis known ⁵⁷ Genetic Tests ²⁹ Susceptibility factor ⁵⁷ Protective ⁶ GeneCards inferred via : Variants (show sections)	15057310 16155733
2	ACE	Angiotensin I Converting Enzyme	Protein Coding	7.98	Novoseek inferred ⁵⁴	17487825 11681014 8733034 (more) 9107443 14968142 9231890 9820054 16003449 18693632 1747216 7796503 15229761 16755313 9657538 9366282
3	KCNIP1	Potassium Voltage-Gated Channel Interacting Protein 1	Protein Coding	7.03	GeneCards inferred via : Variants (show sections)
4	REN	Renin	Protein Coding	5.98	Novoseek inferred ⁵⁴	9422408 2405611
5	KCNMA1	Potassium Calcium-Activated Channel Subfamily M Alpha 1	Protein Coding	5.22	Novoseek inferred ⁵⁴	15057299
6	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	3.85	Novoseek inferred ⁵⁴	16269958

Sources

Variations for Hypertension, Diastolic

ClinVar genetic disease variations for Hypertension, Diastolic:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	KCNMB1	NM_004137.4(KCNMB1):c.193G>A (p.Glu65Lys)	SNV	protective	5941	rs11739136	5:169810796-169810796	5:170383792-170383792

Sources

Expression for Hypertension, Diastolic

Search GEO for disease gene expression data for Hypertension, Diastolic.

Sources

Pathways for Hypertension, Diastolic

Pathways related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE Inhibitor Pathway ¹ Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Renin-angiotensin system ³⁶	11.06	REN ACE
2	Renin secretion ³⁶	10.64	REN KCNMA1 ACE
3	Nitric oxide stimulates guanylate cyclase ⁶⁵ Show member pathways cGMP effects ⁶⁵	10.58	KCNMB1 KCNMA1

Sources

GO Terms for Hypertension, Diastolic

Cellular components related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.43	REN KCNMB1 KCNMA1 KCNIP1 GGT1 ACE
2	voltage-gated potassium channel complex	GO:0008076	8.8	KCNMB1 KCNMA1 KCNIP1

Biological processes related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood pressure	GO:0008217	9.37	REN ACE
2	potassium ion transport	GO:0006813	9.33	KCNMB1 KCNMA1 KCNIP1
3	response to calcium ion	GO:0051592	9.32	KCNMB1 KCNMA1
4	amyloid-beta metabolic process	GO:0050435	9.26	REN ACE
5	potassium ion transmembrane transport	GO:0071805	9.13	KCNMB1 KCNMA1 KCNIP1
6	angiotensin maturation	GO:0002003	8.62	REN ACE

Molecular functions related to Hypertension, Diastolic according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:0008233	9.43	REN GGT1 ACE
2	endopeptidase activity	GO:0004175	9.32	REN ACE
3	potassium channel activity	GO:0005267	9.16	KCNMA1 KCNIP1
4	potassium channel regulator activity	GO:0015459	8.96	KCNMB1 KCNIP1
5	calcium-activated potassium channel activity	GO:0015269	8.62	KCNMB1 KCNMA1

Sources

Sources for Hypertension, Diastolic

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia