Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

EOHSEP MCID: HYP806 MIFTS: 32	Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (EOHSEP) Categories: Genetic diseases
Genes Variations Tissues Publications Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards integrated aliases for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Name: Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy ⁵⁶ ²⁹ ³⁹

Hypertension, Early-Onset, Autosomal Dominant, with Exacerbation in Pregnancy ⁵⁶ ¹³ ⁶

Early-Onset Hypertension with Severe Exacerbation in Pregnancy ⁷³

Hypertensive Disease ⁷¹

Eohsep ⁷³

Characteristics:

HPO:

³¹

hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁶ 605115

MeSH ⁴³ D006973

MedGen ⁴¹ C1854631

SNOMED-CT via HPO ⁶⁸ 24184005 263681008 288250001 more

UMLS ⁷¹ C0020538

Sources

Summaries for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

UniProtKB/Swiss-Prot : ⁷³ Early-onset hypertension with severe exacerbation in pregnancy: Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.

MalaCards based summary : Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy, is also known as hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy, and has symptoms including edema, tremor and chest pain. An important gene associated with Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy is NR3C2 (Nuclear Receptor Subfamily 3 Group C Member 2). The drugs Estradiol and Cyproterone Acetate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial, and related phenotypes are hypertension and decreased circulating aldosterone level

More information from OMIM: 605115

Sources

Related Diseases for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Sources

Symptoms & Phenotypes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Human phenotypes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

³¹

#	Description	HPO Source Accession
1	hypertension ³¹	HP:0000822
2	decreased circulating aldosterone level ³¹	HP:0004319
3	decreased circulating renin level ³¹	HP:0003351
4	maternal hypertension ³¹	HP:0008071

Clinical features from OMIM:

605115

UMLS symptoms related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

edema, tremor, chest pain, angina pectoris, equilibration disorder

Sources

Drugs & Therapeutics for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Drugs for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Cyproterone Acetate

Approved, Investigational

Phase 4

427-51-0

Ethinyl Estradiol

Approved

Phase 4

57-63-6

5991

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Phenylephrine

Approved

Phase 4

59-42-7

6041

Oxymetazoline

Approved, Investigational

Phase 4

1491-59-4

4636

Remifentanil

Approved

Phase 4

132875-61-7

60815

Thiopental

Approved, Vet_approved

Phase 4

76-75-5

3000715

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Isoflurane

Approved, Vet_approved

Phase 4

26675-46-7

3763

Atracurium

Approved, Experimental, Investigational

Phase 4

64228-79-1

47319

Nifedipine

Approved

Phase 4

21829-25-4

4485

Labetalol

Approved

Phase 4

36894-69-6

3869

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

94-09-7, 1994-09-7

2337

Ketorolac

Approved

Phase 4

66635-83-4, 74103-06-3

3826

Acetaminophen

Approved

Phase 4

103-90-2

1983

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Estradiol 17 beta-cypionate

Phase 4

Contraceptive Agents, Male

Phase 4

Androgen Antagonists

Phase 4

Contraceptive Agents

Phase 4

Estradiol 3-benzoate

Phase 4

Androgens

Phase 4

Cyproterone

Phase 4

2098-66-0

5284537

Cyproterone acetate, ethinyl estradiol drug combination

Phase 4

Antihypertensive Agents

Phase 4

Anesthetics

Phase 4

Calcium, Dietary

Phase 4

Analgesics, Opioid

Phase 4

Adrenergic alpha-Antagonists

Phase 4

Adrenergic Agents

Phase 4

Adrenergic Antagonists

Phase 4

Vasodilator Agents

Phase 4

Adrenergic beta-Antagonists

Phase 4

Sympathomimetics

Phase 4

Adrenergic alpha-1 Receptor Antagonists

Phase 4

Neurotransmitter Agents

Phase 4

calcium channel blockers

Phase 4

Analgesics

Phase 4

Analgesics, Non-Narcotic

Phase 4

Narcotics

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Anti-Inflammatory Agents

Phase 4

Antirheumatic Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Valsartan

Approved, Investigational

Phase 3

137862-53-4

60846

Potassium Supplement

Phase 1, Phase 2

Olmesartan

Approved, Investigational

144689-24-7, 144689-63-4

158781 130881

Interventional clinical trials:

(show all 32)

#	Name	Status	NCT ID	Phase	Drugs
1	The Effect of Diane-35 Pretreatment on Endocrine and Clinical Profile for Patients With Polycystic Ovary Syndrome Undergoing In-vitro Fertilization	Unknown status	NCT01752270	Phase 4	Diane-35 pretreatment;Diane-35 pretreatment
2	Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.	Completed	NCT01897155	Phase 4
3	Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients	Completed	NCT03506724	Phase 4	Nifedipine;Labetalol
4	A Randomized Trial Comparing Oral Misoprostol Alone With Oral Misoprostol Followed by Oxytocin in Women Induced for Hypertension of Pregnancy	Recruiting	NCT03749902	Phase 4	Oral misoprostol;Oxytocin
5	Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial	Recruiting	NCT03824119	Phase 4	Ibuprofen 600 mg
6	Randomized, Double Blind, Active-controlled, Parallel Study to Analyse Effects of the Combination of Aliskiren and Valsartan on the Vascular Structure and Function of Retinal Vessels	Completed	NCT01318395	Phase 3	Aliskiren;Placebo
7	The Effect of Potatoes on Potassium Retention, Acid Base Balance, and Blood Pressure	Unknown status	NCT02697708	Phase 1, Phase 2
8	A Randomized, Double-blind, Placebo-controlled, Cross-over, Multi-center Study Assessing the Safety, Tolerability and Efficacy of SER100 10 mg s.c. Twice Daily for 2 Days in Patients With Isolated Systolic Hypertension Insufficiently Treated With One or More Anti-hypertensives.	Completed	NCT01987284	Phase 2	SER100;Placebo
9	A Study on Medication Adherence and "True" Resistance in Patients Referred to a Medical Outpatient Department in Germany With the Diagnosis "Resistant Hypertension".	Unknown status	NCT02128386
10	Acupuncture as Applied Technology to Nursing Care Adult Hypertensive: An Experimental Study.	Unknown status	NCT02530853
11	Effect of Vitamin D3 on Cardiovascular Risk Factors: a Randomized Trial in Human	Completed	NCT01501916
12	Investigation of the Serum MUC3 Protein Levels in Gestational Hypertensive Disease (Preeclampsia-Eclampsia, Pregnancy Induced Hypertension, and HELLP Syndrome) Compared With Normal Pregnancy	Completed	NCT04421183
13	A Multicentre Cross-sectional Study of the Prevalence of Hypertensive Disease in Patients Presenting for Elective Surgery in the Western Cape	Completed	NCT03157661
14	Understanding the Mechanisms of Progressive Decrease in Blood Pressure After Renal Nerve Ablation	Completed	NCT01442883
15	Hypertension of Our Patients: Knowledge, Control, Comorbidity	Completed	NCT01998022
16	Maturational Changes in Cardiac Structures -- Blood Pressure Relationship -- SCOR in Hypertension	Completed	NCT00005469
17	Renal Denervation in Treatment Resistant Hypertension	Completed	NCT01687725
18	Cloud BP System Integrated With CPOE Improves Self-Management of the Hypertensive Patients: A Randomized Controlled Trial Study	Completed	NCT02175511
19	Activating Mass Media for Salt Reduction Program by Using Media Reporters as Research Investigators in a Randomized Controlled Trial	Completed	NCT03074851
20	Circulating Melatonin and 6-hydroxymelatonin Levels During Pregnancy	Completed	NCT03014245
21	Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers	Recruiting	NCT02780414
22	The Use of the Cerebro-placental Ratio to Predict Adverse Outcomes in Pregnancies Complicated by Gestational Diabetes	Recruiting	NCT03072563
23	Use of Meditation as a Complementary Therapy in the Treatment of Gestational Hypertension	Recruiting	NCT03873194
24	EASL: European Registry of Liver Disease in Pregnancy	Recruiting	NCT03834285
25	An Alongside Qualitative Study Exploring Patients' and Health Care Professionals' Expectations and Experiences of Labour Induction With Misoprostol and Oxytocin for Hypertension in Pregnancy in India	Active, not recruiting	NCT04037683		Misoprostol Oral Tablet;Oxytocin
26	A Systematic Review of Factors Associated With Pulmonary Arterial Hypertension in Systemic Sclerosis	Active, not recruiting	NCT03889509
27	Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes (Triabetes) - Alliance of Randomized Trials of Medicine vs. Metabolic Surgery in Type 2 Diabetes ARMMST2D)	Active, not recruiting	NCT01047735
28	Observational Multicenter Study Lasting 12 Months to Determine the Prevalence of Pulmonary Hypertension (PAH) in Patients With Thalassemia Major and Intermedia and Verify the Suitability of Common Diagnostic Criteria in This Population	Active, not recruiting	NCT01496963
29	Antenatal Management Based on Transvaginal Ultrasound Cervical Length Screening for Preventing Preterm Birth	Not yet recruiting	NCT04104984	Early Phase 1	Progesterone Vaginal Suppository;Tocolytic Agents
30	Bioimpedance In Pregnancy and Labour: A Fluid Balance Concept Study.	Not yet recruiting	NCT03823820
31	The Impact of Interleukin-10 in the Invasion Capacity and Immunoregulation During Pregnancy: the Implications of Pathogenesis of Pre-Eclampsia.	Terminated	NCT00154934
32	Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients	Withdrawn	NCT03897790

Search NIH Clinical Center for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Acebutolol

Acebutolol Hydrochloride

Amiloride

Amiloride Hydrochloride

Amlodipine

Amlodipine Besylate

Angelica sinensis preparation

Antihypertensives, Other

Atenolol

benazepril

Benazepril hydrochloride

Bendroflumethiazide

benzthiazide

Bepridil

Bepridil hydrochloride

Betaxolol

Betaxolol Hydrochloride

Bisoprolol

Bisoprolol Fumarate

Bumetanide

candesartan

candesartan cilexetil

Carteolol

Carteolol Hydrochloride

carvedilol

carvedilol phosphate

Chlorothiazide

Chlorothiazide sodium

Chlorthalidone

Clonidine

CLONIDINE HCL PWDR

Clonidine Hydrochloride

coenzyme Q10

cyclothiazide

deserpidine

Diltiazem

Diltiazem Hydrochloride

Diltiazem maleate

DITIAZ

Doxazosin

Doxazosin Mesylate

eplerenone

eprosartan

Eprosartan mesylate

esmolol

Esmolol hydrochloride

Ethacrynate Sodium

Ethacrynic Acid

Felodipine

Fish Oils

Fosinopril

Fosinopril Sodium

Furosemide

Guanabenz

Guanabenz Acetate

guanadrel

Guanadrel sulfate

Guanethidine

Guanethidine Monosulfate

Guanfacine

Guanfacine Hydrochloride

Hydrochlorothiazide

Hydroflumethiazide

Indapamide

irbesartan

Isradipine

Lisinopril

Losartan

Losartan Potassium

Methyclothiazide

Methyldopa

Methyldopate hydrochloride

Metolazone

Metoprolol

metoprolol succinate

Metoprolol Tartrate

Mibefradil

Mibefradil Dihydrochloride

moexipril

Moexipril hydrochloride

Nadolol

Nicardipine

Nicardipine hydrochloride

Nifedipine

Nisoldipine

Oil of garlic

olmesartan

Olmesartan medoxomil

Penbutolol

Penbutolol Sulfate

Perindopril

Perindopril arginine

Perindopril Erbumine

Pindolol

Polythiazide

Prazosin

Prazosin hydrochloride

Propranolol

Propranolol Hydrochloride

quinapril

Quinapril hydrochloride

quinethazone

Ramipril

Reserpine

Spironolactone

SPIRONOLACTONE PWDR

telmisartan

Terazosin

terazosin hydrochloride

Timolol

Timolol Hemihydrate

Timolol Maleate

torsemide

trandolapril

Triamterene

Trichlormethiazide

valsartan

Verapamil

Verapamil hydrochloride

Sources

Genetic Tests for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genetic tests related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

#	Genetic test	Affiliating Genes
1	Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy ²⁹	NR3C2

Sources

Anatomical Context for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards organs/tissues related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

⁴⁰

Heart, Kidney, Endothelial, Testes, Brain, Liver, Placenta

Sources

Publications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Articles related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

(show top 50) (show all 2566)

#	Title	Authors	PMID	Year
1	Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. ⁵⁶ ⁶	Geller DS...Lifton RP	10884226	2000
2	Neonatal Seizures Among Low-Risk Pregnancies at Term: Risk Factors and Adverse Outcomes. ⁶¹	Doty MS...Chauhan SP	32459434	2020
3	Characteristics and preventability of obstetric intensive care unit admissions in Far North Queensland. ⁶¹	Jayaratnam S...de Costa C	32557552	2020
4	Blood-brain barrier dysfunction: the undervalued frontier of hypertension. ⁶¹	Katsi V...Tousoulis D	32424144	2020
5	Early gestational diabetes screening in obese women: a randomized controlled trial. ⁶¹	Harper LM...Tita AT	31926951	2020
6	Placental Overexpression of Soluble CORIN in Preeclampsia. ⁶¹	Degrelle SA...Tsatsaris V	32084366	2020
7	Caesarean birth by maternal request: a poorly understood phenomenon in low- and middle-income countries. ⁶¹	Harrison MS...Krebs NF	32478383	2020
8	The predictive capacity of uterine artery Doppler for preterm birth-A cohort study. ⁶¹	van Zijl MD...Pajkrt E	31715024	2020
9	Developing and applying a costing tool for hypertension and related cardiovascular disease: Attributable costs to salt/sodium consumption. ⁶¹	Nilson EAF...Jaime PC	32108425	2020
10	The WNK signaling pathway and salt-sensitive hypertension. ⁶¹	Furusho T...Sohara E	32286498	2020
11	Society for Maternal-Fetal Medicine (SMFM) Consult Series #50: The role of activity restriction in obstetric management. ⁶¹	Society for Maternal-Fetal Medicine (SMFM)...Osmundson S	32360110	2020
12	Notch3 in Development, Health and Disease. ⁶¹	Hosseini-Alghaderi S...Baron M	32210034	2020
13	Twins versus singleton pregnancies: outcomes in small for gestational age late preterm deliveries. ⁶¹	Walker AR...Caughey AB	30078342	2020
14	Development of a prediction model to target screening for high blood pressure in children. ⁶¹	Hamoen M...de Kroon MLA	31981642	2020
15	Comparison and evaluation of Abbott chemiluminescent microparticle immunoassay and ChIVD light-initiated chemiluminescent assay in the detection of Treponema pallidum antibody. ⁶¹	Chen X...Cui L	32133697	2020
16	Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach. ⁶¹	Gu S...Lai LH	31530902	2020
17	Alterations on a key nephrogenic/cardiogenic gene expression linked to hypertension development. ⁶¹	Mazzei L...Manucha W	31472952	2020
18	Laparoscopic mini/one anastomosis gastric bypass: anatomic features, imaging, efficacy and postoperative complications. ⁶¹	Scavone G...Scavone A	32189194	2020
19	Cost Effectiveness of Antenatal Lifestyle Interventions for Preventing Gestational Diabetes and Hypertensive Disease in Pregnancy. ⁶¹	Bailey C...Ademi Z	32026397	2020
20	Does the AQHI reduce cardiovascular hospitalization in Hong Kong's elderly population? ⁶¹	Mason TG...Tian L	31801101	2020
21	The association between high particulate matter pollution and daily cause-specific hospital admissions: a time-series study in Yichang, China. ⁶¹	Yao C...Lam KBH	31848968	2020
22	Harmonising research outcomes for polycystic ovary syndrome: an international multi-stakeholder core outcome set. ⁶¹	Al Wattar BH...Thangaratinam S	32020203	2020
23	Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension. ⁶¹	Kostrzewska M...Guzik P	32026418	2020
24	Early Onset Severe Hypertensive Disease in Pregnancy and Screening for Antiphospholipid Syndrome. ⁶¹	Sobhani NC...Gonzalez JM	32140289	2020
25	Risks of cause-specific mortality in offspring of pregnancies complicated by hypertensive disease of pregnancy. ⁶¹	Hammad IA...Varner MW	31336073	2020
26	Central hemodynamics are associated with fetal outcomes in pregnancies of advanced maternal age. ⁶¹	Yin O...Afshar Y	31923879	2020
27	Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy. ⁶¹	Wilson DL...Walker SP	32339208	2020
28	Initial-onset symptoms of preeclampsia and their relation to pregnancy outcomes. ⁶¹	Zhuang X...Lin JH	31790312	2019
29	Association of Cardiovascular Disease With Premature Mortality in the United States. ⁶¹	Chen Y...Berrington de Gonzalez A	31617863	2019
30	Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up. ⁶¹	Yu Y...Li J	31801789	2019
31	Urban-rural comparisons in health risk factor, health status and outcomes in Tianjin, China: A cross-sectional survey (2009-2013). ⁶¹	Luo D...Yang W	31614059	2019
32	Prevalence and determinants of stillbirth in Nigerian referral hospitals: a multicentre study. ⁶¹	Okonofua FE...Randawa A	31888536	2019
33	Cardiovascular Disease and hospital admissions in African immigrants and former Soviet Union immigrants: A retrospective cohort study. ⁶¹	Reuven Y...Dreiher J	31477314	2019
34	Comparison of four prognostic scales for predicting mortality in patients with severe maternal morbidity. ⁶¹	Jonguitud Lopez B...Palacios Saucedo GC	31810578	2019
35	[The remote results of treatment of ischemic stroke conditioned by atherosclerotic affection of carotid arteries]. ⁶¹	Kovalenko IB...Lykov YA	31884766	2019
36	The Steroid Profile of Adrenal Incidentalomas: Subtyping Subjects With High Cardiovascular Risk. ⁶¹	Di Dalmazi G...Pagotto U	31381072	2019
37	Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia. ⁶¹	Zhao J...Qi H	31399951	2019
38	Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes. ⁶¹	Brosens I...Benagiano G	31163132	2019
39	Impact of Perinatal Different Intrauterine Environments on Child Growth and Development: Planning and Baseline Data for a Cohort Study. ⁶¹	Werlang ICR...Goldani MZ	31714249	2019
40	Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study. ⁶¹	Li X...Theodoratou E	31626644	2019
41	Nitric Oxide in the Prevention of Pre-eclampsia (NOPE): A Double-Blind Randomized Placebo-Controlled Trial Assessing the Efficacy of Isosorbide Mononitrate in the Prevention of Pre-eclampsia in High-Risk Women. ⁶¹	Ponmozhi G...Manikandan K	31686742	2019
42	A new customised placental weight standard redefines the relationship between maternal obesity and extremes of placental size and is more closely associated with pregnancy complications than an existing population standard. ⁶¹	Wallace JM...Horgan GW	31587680	2019
43	Obstetric Complications of Donor Egg Conception Pregnancies. ⁶¹	Shah A...Garner J	31598040	2019
44	Peripartum Cardiomyopathy: A Review. ⁶¹	Ballard LC...Kea B	31534832	2019
45	Influence of intrauterine growth restriction on caesarean delivery risk among preterm pregnancies undergoing induction of labor for hypertensive disease. ⁶¹	Wilk C...Abenhaim HA	31290217	2019
46	SAFE@HOME - Feasibility study of a telemonitoring platform combining blood pressure and preeclampsia symptoms in pregnancy care. ⁶¹	van den Heuvel JFM...Bekker MN	31330428	2019
47	A National Dataset Analysis of older adults in emergency department observation units. ⁶¹	Southerland LT...Mion LC	30563716	2019
48	[Maternal deaths in Sweden: Diagnostics and clinical management could be improved]. ⁶¹	Grunewald C...Saltvedt S	31573669	2019
49	[Participation of Sphingolipids in the Pathogenesis of Atherosclerosis]. ⁶¹	Alessenko AV...Kurochkin IN	31397233	2019
50	Telemonitoring for hypertensive disease in pregnancy. ⁶¹	Khalil A...Gyselaers W	31282755	2019

Sources

Genes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	1300	Molecular basis known ⁵⁶ Pathogenic ⁶ Causative variation ⁷³ Genetic Tests ²⁹	10884226

Sources

Variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

ClinVar genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

⁶ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	NR3C2	NM_000901.5(NR3C2):c.2429C>T (p.Ser810Leu)	SNV	Pathogenic	8557	rs41511344	4:149073701-149073701	4:148152550-148152550

UniProtKB/Swiss-Prot genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

⁷³

#	Symbol	AA change	Variation ID	SNP ID
1	NR3C2	p.Ser810Leu	VAR_015626	rs41511344

Sources

Expression for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Search GEO for disease gene expression data for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy.

Sources

Pathways for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Sources

GO Terms for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Sources

Sources for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (EOHSEP)

Aliases & Classifications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards integrated aliases for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Characteristics:

HPO:

Classifications:

External Ids:

Summaries for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Related Diseases for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Symptoms & Phenotypes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Human phenotypes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Clinical features from OMIM:

UMLS symptoms related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Drugs & Therapeutics for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Drugs for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Genetic Tests for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genetic tests related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Anatomical Context for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards organs/tissues related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Publications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Articles related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Genes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (1 elite genes):

Variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

ClinVar genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

UniProtKB/Swiss-Prot genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Expression for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Pathways for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

GO Terms for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Sources for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :