Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

EOHSEP MCID: HYP806 MIFTS: 34	Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (EOHSEP) Categories: Cardiovascular diseases, Genetic diseases, Nephrological diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards integrated aliases for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Name: Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy ⁵⁷ ²⁹ ⁴⁰

Hypertension, Early-Onset, Autosomal Dominant, with Exacerbation in Pregnancy ⁵⁷ ¹³ ⁶

Hypertension Due to Gain-of-Function Mutations in the Mineralocorticoid Receptor ⁵⁹

Early-Onset Hypertension with Severe Exacerbation in Pregnancy ⁷⁴

Early-Onset Hypertension with Exacerbation in Pregnancy ⁵⁹

Pseudohyperaldosteronism Type 2 ⁵⁹

Hypertensive Disease ⁷²

Eohsep ⁷⁴

Characteristics:

HPO:

³²

hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Cardiovascular diseases Nephrological diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the circulatory system

Hypertensive diseases

Secondary hypertension

Hypertension secondary to other renal disorders

Orphanet: ⁵⁹

Rare circulatory system diseases

Rare renal diseases

Rare gynaecological and obstetric diseases

External Ids:

OMIM ⁵⁷ 605115

MeSH ⁴⁴ D006973

ICD10 via Orphanet ³⁴ I15.1

UMLS via Orphanet ⁷³ C1854631

Orphanet ⁵⁹ ORPHA88660

MedGen ⁴² C1854631

UMLS ⁷² C0020538

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Summaries for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

UniProtKB/Swiss-Prot : ⁷⁴ Early-onset hypertension with severe exacerbation in pregnancy: Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.

MalaCards based summary : Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy, is also known as hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy, and has symptoms including tremor, angina pectoris and edema. An important gene associated with Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy is NR3C2 (Nuclear Receptor Subfamily 3 Group C Member 2). The drugs Ethinyl Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial, and related phenotypes are hypertension and decreased circulating aldosterone level

More information from OMIM: 605115

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Related Diseases for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

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Symptoms & Phenotypes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Human phenotypes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

³²

#	Description	HPO Source Accession
1	hypertension ³²	HP:0000822
2	decreased circulating aldosterone level ³²	HP:0004319
3	maternal hypertension ³²	HP:0008071
4	decreased circulating renin level ³²	HP:0003351

Clinical features from OMIM:

605115

UMLS symptoms related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

tremor, angina pectoris, edema, chest pain, equilibration disorder

Sources

Drugs & Therapeutics for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Drugs for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ethinyl Estradiol

Approved

Phase 4

57-63-6

5991

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Cyproterone Acetate

Approved, Investigational

Phase 4

427-51-0

Oxymetazoline

Approved, Investigational

Phase 4

1491-59-4

4636

Phenylephrine

Approved

Phase 4

59-42-7

6041

Remifentanil

Approved

Phase 4

132875-61-7

60815

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Ephedrine

Approved

Phase 4

299-42-3

9294

Pseudoephedrine

Approved

Phase 4

90-82-4

7028

Thiopental

Approved, Vet_approved

Phase 4

76-75-5

3000715

Atracurium

Approved, Experimental, Investigational

Phase 4

64228-79-1

47319

Isoflurane

Approved, Vet_approved

Phase 4

26675-46-7

3763

Nifedipine

Approved

Phase 4

21829-25-4

4485

Labetalol

Approved

Phase 4

36894-69-6

3869

Acetaminophen

Approved

Phase 4

103-90-2

1983

Ketorolac

Approved

Phase 4

74103-06-3, 66635-83-4

3826

Ibuprofen

Approved

Phase 4

15687-27-1

3672

tannic acid

Approved

Phase 4

1401-55-4

Oxytocin

Approved, Vet_approved

Phase 4

50-56-6

439302 53477758

Misoprostol

Approved

Phase 4

59122-46-2

5282381

Benzocaine

Approved, Investigational

Phase 4

94-09-7, 1994-09-7

2337

Calcium

Approved, Nutraceutical

Phase 4

7440-70-2

271

Contraceptive Agents

Phase 4

Contraceptive Agents, Male

Phase 4

Androgens

Phase 4

Hormone Antagonists

Phase 4

Cyproterone

Phase 4

2098-66-0

5284537

Cyproterone acetate, ethinyl estradiol drug combination

Phase 4

Estradiol 3-benzoate

Phase 4

Estradiol 17 beta-cypionate

Phase 4

Androgen Antagonists

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

Antihypertensive Agents

Phase 4

Anesthetics

Phase 4

Central Nervous System Depressants

Phase 4

Vasoconstrictor Agents

Phase 4

Hormones

Phase 4

Calcium, Dietary

Phase 4

Anesthetics, Local

Phase 4

Sympathomimetics

Phase 4

Neurotransmitter Agents

Phase 4

Cardiotonic Agents

Phase 4

Adrenergic Agonists

Phase 4

Respiratory System Agents

Phase 4

Nasal Decongestants

Phase 4

Adrenergic alpha-Agonists

Phase 4

Mydriatics

Phase 4

Analgesics, Opioid

Phase 4

Protective Agents

Phase 4

Interventional clinical trials:

(show all 29)

#	Name	Status	NCT ID	Phase	Drugs
1	The Effect of Diane-35 Pretreatment on Endocrine and Clinical Profile for Patients With Polycystic Ovary Syndrome Undergoing In-vitro Fertilization	Unknown status	NCT01752270	Phase 4	Diane-35 pretreatment;Diane-35 pretreatment
2	Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.	Completed	NCT01897155	Phase 4
3	Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients	Completed	NCT03506724	Phase 4	Nifedipine;Labetalol
4	Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial	Recruiting	NCT03824119	Phase 4	Ibuprofen 600 mg
5	A Randomized Trial Comparing Oral Misoprostol Alone With Oral Misoprostol Followed by Oxytocin in Women Induced for Hypertension of Pregnancy	Not yet recruiting	NCT03749902	Phase 4	Oral misoprostol;Oxytocin
6	Randomized, Double Blind, Active-controlled, Parallel Study to Analyse Effects of the Combination of Aliskiren and Valsartan on the Vascular Structure and Function of Retinal Vessels	Completed	NCT01318395	Phase 3	Aliskiren;Placebo
7	A Randomized, Double-blind, Placebo-controlled, Cross-over, Multi-center Study Assessing the Safety, Tolerability and Efficacy of SER100 10 mg s.c. Twice Daily for 2 Days in Patients With Isolated Systolic Hypertension Insufficiently Treated With One or More Anti-hypertensives.	Completed	NCT01987284	Phase 2	SER100;Placebo
8	The Effect of Potatoes on Potassium Retention, Acid Base Balance, and Blood Pressure	Active, not recruiting	NCT02697708	Phase 1, Phase 2
9	A Study on Medication Adherence and "True" Resistance in Patients Referred to a Medical Outpatient Department in Germany With the Diagnosis "Resistant Hypertension".	Unknown status	NCT02128386
10	Understanding the Mechanisms of Progressive Decrease in Blood Pressure After Renal Nerve Ablation	Unknown status	NCT01442883
11	Acupuncture as Applied Technology to Nursing Care Adult Hypertensive: An Experimental Study.	Unknown status	NCT02530853
12	Observational Multicenter Study Lasting 12 Months to Determine the Prevalence of Pulmonary Hypertension (PAH) in Patients With Thalassemia Major and Intermedia and Verify the Suitability of Common Diagnostic Criteria in This Population	Unknown status	NCT01496963
13	Effect of Vitamin D3 on Cardiovascular Risk Factors: a Randomized Trial in Human	Completed	NCT01501916
14	A Multicentre Cross-sectional Study of the Prevalence of Hypertensive Disease in Patients Presenting for Elective Surgery in the Western Cape	Completed	NCT03157661
15	Hypertension of Our Patients: Knowledge, Control, Comorbidity	Completed	NCT01998022
16	Cloud BP System Integrated With CPOE Improves Self-Management of the Hypertensive Patients: A Randomized Controlled Trial Study	Completed	NCT02175511
17	Maturational Changes in Cardiac Structures -- Blood Pressure Relationship -- SCOR in Hypertension	Completed	NCT00005469
18	Activating Mass Media for Salt Reduction Program by Using Media Reporters as Research Investigators in a Randomized Controlled Trial	Completed	NCT03074851
19	Circulating Melatonin and 6-hydroxymelatonin Levels During Pregnancy	Completed	NCT03014245
20	The Use of the Cerebro-placental Ratio to Predict Adverse Outcomes in Pregnancies Complicated by Gestational Diabetes	Recruiting	NCT03072563
21	Renal Denervation in Treatment Resistant Hypertension	Recruiting	NCT01687725
22	EASL: European Registry of Liver Disease in Pregnancy	Recruiting	NCT03834285
23	Use of Meditation as a Complementary Therapy in the Treatment of Gestational Hypertension	Recruiting	NCT03873194
24	A Systematic Review of Factors Associated With Pulmonary Arterial Hypertension in Systemic Sclerosis	Active, not recruiting	NCT03889509
25	Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers	Active, not recruiting	NCT02780414
26	Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes (Triabetes) - Alliance of Randomized Trials of Medicine vs. Metabolic Surgery in Type 2 Diabetes ARMMST2D)	Active, not recruiting	NCT01047735
27	Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients	Not yet recruiting	NCT03897790
28	An Alongside Qualitative Study Exploring Patients' and Health Care Professionals' Expectations and Experiences of Labour Induction With Misoprostol and Oxytocin for Hypertension in Pregnancy in India	Not yet recruiting	NCT04037683		Misoprostol Oral Tablet;Oxytocin
29	Bioimpedance In Pregnancy and Labour: A Fluid Balance Concept Study.	Not yet recruiting	NCT03823820

Search NIH Clinical Center for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy

Inferred drug relations via UMLS ⁷² / NDF-RT ⁵¹ :

Acebutolol

Acebutolol Hydrochloride

Amiloride

Amiloride Hydrochloride

Amlodipine

Amlodipine Besylate

Angelica sinensis preparation

Antihypertensives, Other

Atenolol

benazepril

Benazepril hydrochloride

Bendroflumethiazide

benzthiazide

Bepridil

Bepridil hydrochloride

Betaxolol

Betaxolol Hydrochloride

Bisoprolol

Bisoprolol Fumarate

Bumetanide

candesartan

candesartan cilexetil

Carteolol

Carteolol Hydrochloride

carvedilol

carvedilol phosphate

Chlorothiazide

Chlorothiazide sodium

Chlorthalidone

Clonidine

CLONIDINE HCL PWDR

Clonidine Hydrochloride

coenzyme Q10

cyclothiazide

deserpidine

Diltiazem

Diltiazem Hydrochloride

Diltiazem maleate

DITIAZ

Doxazosin

Doxazosin Mesylate

eplerenone

eprosartan

Eprosartan mesylate

esmolol

Esmolol hydrochloride

Ethacrynate Sodium

Ethacrynic Acid

Felodipine

Fish Oils

Fosinopril

Fosinopril Sodium

Furosemide

Guanabenz

Guanabenz Acetate

guanadrel

Guanadrel sulfate

Guanethidine

Guanethidine Monosulfate

Guanfacine

Guanfacine Hydrochloride

Hydrochlorothiazide

Hydroflumethiazide

Indapamide

irbesartan

Isradipine

Lisinopril

Losartan

Losartan Potassium

Methyclothiazide

Methyldopa

Methyldopate hydrochloride

Metolazone

Metoprolol

metoprolol succinate

Metoprolol Tartrate

Mibefradil

Mibefradil Dihydrochloride

moexipril

Moexipril hydrochloride

Nadolol

Nicardipine

Nicardipine hydrochloride

Nifedipine

Nisoldipine

Oil of garlic

olmesartan

Olmesartan medoxomil

Penbutolol

Penbutolol Sulfate

Perindopril

Perindopril arginine

Perindopril Erbumine

Pindolol

Polythiazide

Prazosin

Prazosin hydrochloride

Propranolol

Propranolol Hydrochloride

quinapril

Quinapril hydrochloride

quinethazone

Ramipril

Reserpine

Spironolactone

SPIRONOLACTONE PWDR

telmisartan

Terazosin

terazosin hydrochloride

Timolol

Timolol Hemihydrate

Timolol Maleate

torsemide

trandolapril

Triamterene

Trichlormethiazide

valsartan

Verapamil

Verapamil hydrochloride

Sources

Genetic Tests for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genetic tests related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

#	Genetic test	Affiliating Genes
1	Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy ²⁹	NR3C2

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Anatomical Context for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards organs/tissues related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

⁴¹

Heart, Kidney, Endothelial, Testes, Brain, Liver, Placenta

Sources

Publications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Articles related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

(show top 50) (show all 2522)

#	Title	Authors	PMID	Year
1	Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. ⁸ ⁷¹	Geller DS...Lifton RP	10884226	2000
2	[Participation of Sphingolipids in the Pathogenesis of Atherosclerosis]. ³⁸	Alessenko AV...Kurochkin IN	31397233	2019
3	Telemonitoring for hypertensive disease in pregnancy. ³⁸	Khalil A...Gyselaers W	31282755	2019
4	A Comparative Study on the Memory-Enhancing Actions of Oral Renin-Angiotensin System Altering Drugs in Scopolamine-Treated Mice. ³⁸	Ababei DC...Bild W	31106575	2019
5	Cardiac output measurements during high-risk Cesarean section using electrical bioreactance or arterial waveform analysis: assessment of agreement. ³⁸	Gutierrez J...Khalil A	30302868	2019
6	The steroid profile of adrenal incidentalomas: subtyping subjects with high cardiovascular risk. ³⁸	Di Dalmazi G...Pagotto U	31381072	2019
7	Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia. ³⁸	Zhao J...Qi H	31399951	2019
8	Risks of cause-specific mortality in offspring of pregnancies complicated by hypertensive disease of pregnancy. ³⁸	Hammad IA...Varner MW	31336073	2019
9	Influence of intrauterine growth restriction on caesarean delivery risk among preterm pregnancies undergoing induction of labor for hypertensive disease. ³⁸	Wilk C...Abenhaim HA	31290217	2019
10	Relating the number of human leucocytes antigen mismatches to pregnancy complications in oocyte donation pregnancies: study protocol for a prospective multicentre cohort study (DONOR study). ³⁸	van Bentem K...van der Hoorn ML	31345965	2019
11	Right ventricular dysfunction in arterial hypertension: still terra incognita? ³⁸	Marketou M...Parthenakis F	31076653	2019
12	SAFE@HOME - Feasibility study of a telemonitoring platform combining blood pressure and preeclampsia symptoms in pregnancy care. ³⁸	van den Heuvel JFM...Bekker MN	31330428	2019
13	Professional Driver's Job Stress and 8-year Risk of Cardiovascular Disease: The Taiwan Bus Driver Cohort Study. ³⁸	Wu WT...Liou SH	31181005	2019
14	Pattern of cardiac remodelling of the left ventricle in patients with essential hypertensive disease and concomitant type 2 diabetes mellitus. ³⁸	Ikwuka A...Virstyuk N	31345920	2019
15	The immature platelet fraction in hypertensive disease during pregnancy. ³⁸	Bernstein U...Jank A	30810879	2019
16	Effects of context-aware patient guidance on blood pressure self-measurement adherence levels. ³⁸	Lindahl C...Sandager P	28701078	2019
17	ATP release drives heightened immune responses associated with hypertension. ³⁸	Zhao TV...Shen XZ	31253642	2019
18	In-utero and perinatal influences on suicide risk: a systematic review and meta-analysis. ³⁸	Orri M...Geoffroy MC	31029623	2019
19	Placental Bed Research: 1. The Placental Bed. From Spiral Arteries Remodeling to the Great Obstetrical Syndromes. ³⁸	Brosens I...Benagiano G	31163132	2019
20	Surgical outcome in aortopulmonary window beyond the neonatal period. ³⁸	Kumar V...Jaswal V	30900319	2019
21	Correlates of neutrophil/lymphocyte, platelet/lymphocyte, and platelet/neutrophil ratios of neonates of women with hypertensive disease of pregnancy with neonatal birth outcomes. ³⁸	Okoye HC...Ilechukwu G	30835575	2019
22	Hypertensive Diseases of Pregnancy Increase Risk of Readmission With Heart Failure: A National Readmissions Database Study. ³⁸	Nizamuddin J...Shahul S	30577972	2019
23	The placental bed vascular pathology revisited: a risk indicator for cardiovascular disease. ³⁸	Brosens I...Benagiano G	29172831	2019
24	Interfacility Transport of the Pregnant Patient: A 5-year Retrospective Review of a Single Critical Care Transport Program. ³⁸	Nawrocki PS...Margolis A	30188241	2019
25	Low fetal fraction of cell-free DNA predicts placental dysfunction and hypertensive disease in pregnancy. ³⁸	Gerson KD...Spiel MH	31056151	2019
26	Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise. ³⁸	Braschi A	30714087	2019
27	Delivery or expectant management for prevention of adverse maternal and neonatal outcomes in hypertensive disorders of pregnancy: an individual participant data meta-analysis. ³⁸	Bernardes TP...Groen H	30697855	2019
28	Socioeconomic factors and mortality due to cerebrovascular and hypertensive disease in Brazil. ³⁸	Villela PB...de Oliveira GMM	31028004	2019
29	Management of Hypertension in the Obese Pregnant Patient. ³⁸	Coroyannakis C...Khalil A	30915600	2019
30	Clinical efficacy of acute respiratory viral infections prevention in patients with chronic heart failure. ³⁸	Budnevsky AV...Tokmachev RE	31094457	2019
31	Prevalence of colonisation by group B streptococcus in pregnant patients in Taguatinga, Federal District, Brazil: a cross-sectional study. ³⁸	Siqueira F...Dias A	30656444	2019
32	Gestational hypertensive disorders show unique patterns of circulatory deterioration with ongoing pregnancy. ³⁸	Gyselaers W...Bruckers L	30673301	2019
33	Association between endoglin/transforming growth factor beta receptors 1, 2 gene polymorphisms and the level of soluble endoglin with preeclampsia in Egyptian women. ³⁸	ElMonier AA...Shaheen AA	30496724	2019
34	Placental growth factor as an indicator of fetal growth restriction in late-onset small-for-gestational age pregnancies. ³⁸	Anderson N...McCowan L	29851029	2019
35	[Estudio sobre la asociación de hipertrigliceridemia con los estados hipertensivos del embarazo]. ³⁸	Serrano-Berrones MA...Barragan-Padilla SB	31182871	2019
36	The Evaluation of a 19-Year-Old With Hypertension and Proteinuria: A Case Report. ³⁸	Edison M...Miller N	31064291	2019
37	Hypertensive ocular disease in cats: A guide to fundic lesions to facilitate early diagnosis. ³⁸	Carter J	30763152	2019
38	Validation of the iHealth Track and Omron HEM-9210T automated blood pressure devices for use in pregnancy. ³⁸	Van Den Heuvel JFM...Bekker MN	30825925	2019
39	Maternal and perinatal outcomes after elective induction of labor at 39 weeks in uncomplicated singleton pregnancy: a meta-analysis. ³⁸	Sotiriadis A...Hyett J	30298532	2019
40	[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia]. ³⁸	Anisimova AV...Nasedkina TV	31184626	2019
41	Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo. ³⁸	Yoshida S...Sohara E	29869755	2018
42	A National Dataset Analysis of older adults in emergency department observation units. ³⁸	Southerland LT...Mion LC	30563716	2018
43	Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions. ³⁸	Sugiura Y...Nishimoto K	30571232	2018
44	GENDER DISPARITIES OF CIRCULATORY DISEASE PROGRESS IN THE CHORNOBYL ACCIDENT CLEAN-UP WORKERS AND PHOSPHODIESTERASE 4D GENE rs966221 POLYMORPHISM. ³⁸	Bilyi DO...Abramenko IV	30582852	2018
45	Influence of Time Interval from Bariatric Surgery to Conception on Pregnancy and Perinatal Outcomes. ³⁸	Rasteiro C...Ramalho C	30027331	2018
46	Prospective observational study to determine the accuracy of first-trimester serum biomarkers and uterine artery Dopplers in combination with maternal characteristics and arteriography for the prediction of women at risk of preeclampsia and other adverse pregnancy outcomes. ³⁸	Allen R...Aquilina J	28714317	2018
47	Erythrocyte heme‑oxygenation status indicated as a risk factor in prehypertension by Raman spectroscopy. ³⁸	Wrobel TP...Grodzicki T	30251685	2018
48	Dynamic prediction of childhood high blood pressure in a population-based birth cohort: a model development study. ³⁸	Hamoen M...de Kroon MLA	30467134	2018
49	PATHOGENETIC LINKS OF THE COMBINED COURSE OF CHRONIC PANCREATITIS AND HYPERTENSIVE DISEASE AND THEIR ROLE IN THE FORMATION OF COMPLICATIONS. ³⁸	Viun T...Pasieshvili L	30516499	2018
50	Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension. ³⁸	Uiterwijk R...van Oostenbrugge RJ	30277642	2018

Sources

Genes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	1650	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative germline mutation (gain of function) ⁵⁹ Causative variation ⁷⁴ Genetic Tests ²⁹	10884226

Sources

Variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

ClinVar genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

⁶

#	Gene	Variation	Type	Significance	SNP ID	GRCh37 Pos	GRCh38 Pos
1	NR3C2	NM_000901.5(NR3C2): c.2429C> T (p.Ser810Leu)	single nucleotide variant	Pathogenic	rs41511344	4:149073701-149073701	4:148152550-148152550

UniProtKB/Swiss-Prot genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

⁷⁴

#	Symbol	AA change	Variation ID	SNP ID
1	NR3C2	p.Ser810Leu	VAR_015626	rs41511344

Sources

Expression for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Search GEO for disease gene expression data for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy.

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Pathways for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

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GO Terms for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

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Sources for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

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³⁴ ICD10 via Orphanet

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³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

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⁴⁰ LOVD

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⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia

Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (EOHSEP)

Aliases & Classifications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards integrated aliases for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Characteristics:

HPO:

Classifications:

External Ids:

Summaries for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Related Diseases for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Symptoms & Phenotypes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Human phenotypes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Clinical features from OMIM:

UMLS symptoms related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Drugs & Therapeutics for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Drugs for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 72 / NDF-RT 51 :

Genetic Tests for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genetic tests related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Anatomical Context for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

MalaCards organs/tissues related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Publications for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Articles related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Genes for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Genes related to Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy (1 elite genes):

Variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

ClinVar genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

UniProtKB/Swiss-Prot genetic disease variations for Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy:

Expression for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Pathways for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

GO Terms for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Sources for Hypertension, Early-Onset, Autosomal Dominant, with Severe...

Inferred drug relations via UMLS ⁷² / NDF-RT ⁵¹ :