MCID: HYP034
MIFTS: 38

Hypertensive Encephalopathy

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Hypertensive Encephalopathy

MalaCards integrated aliases for Hypertensive Encephalopathy:

Name: Hypertensive Encephalopathy 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9427
ICD10 33 I67.4
ICD9CM 35 437.2
MeSH 44 D020343
NCIt 50 C3503
UMLS 73 C0151620

Summaries for Hypertensive Encephalopathy

MalaCards based summary : Hypertensive Encephalopathy is related to malignant hypertension and renal hypertension. An important gene associated with Hypertensive Encephalopathy is EPO (Erythropoietin), and among its related pathways/superpathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin secretion. The drugs Antihypertensive Agents and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and endothelial, and related phenotype is cardiovascular system.

Wikipedia : 76 Hypertensive encephalopathy (HE) is general brain dysfunction due to significantly high blood pressure.... more...

Related Diseases for Hypertensive Encephalopathy

Diseases related to Hypertensive Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 30.2 ACE REN
2 renal hypertension 28.8 ACE EPO REN
3 encephalopathy 10.8
4 cerebritis 10.2
5 hyporeninemic hypoaldosteronism 10.1 ACE REN
6 renal artery obstruction 10.1 ACE REN
7 hypoaldosteronism 10.1 ACE REN
8 hypertensive retinopathy 10.1 ACE REN
9 hypertension, diastolic 10.1 ACE REN
10 orthostatic proteinuria 10.1 ACE REN
11 atrial septal defect 4 10.1 ACE REN
12 malignant essential hypertension 10.1 ACE REN
13 anuria 10.1 ACE REN
14 fibromuscular dysplasia 10.0 ACE REN
15 hepatorenal syndrome 10.0 ACE REN
16 renal tubular dysgenesis 10.0 ACE REN
17 renovascular hypertension 10.0 ACE REN
18 ureteral disease 10.0 ACE REN
19 end stage renal failure 10.0 ACE EPO
20 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 ACE REN
21 interstitial nephritis 10.0 ACE REN
22 microvascular complications of diabetes 3 10.0 ACE REN
23 diabetic neuropathy 10.0 ACE EPO
24 oligohydramnios 10.0 ACE REN
25 aortic valve disease 1 10.0 ACE REN
26 headache 10.0
27 pulmonary edema 10.0 ACE REN
28 hypokalemia 10.0 ACE REN
29 polycystic kidney disease 1 with or without polycystic liver disease 10.0 ACE REN
30 eclampsia 9.9
31 renal dysplasia 9.9 ACE REN
32 sleep apnea 9.9 ACE REN
33 glomerulonephritis 9.9
34 immune system disease 9.8 ACE EPO
35 glucose metabolism disease 9.8 ACE REN
36 myoma 9.8 CYP19A1 EPO
37 hydrocephalus 9.8
38 aortic valve disease 2 9.8 ACE REN
39 iga glomerulonephritis 9.8 ACE REN
40 arteries, anomalies of 9.8 ACE REN
41 ovarian hyperstimulation syndrome 9.7 CYP19A1 REN
42 pheochromocytoma 9.7
43 stroke, ischemic 9.7
44 polyarteritis nodosa, childhood-onset 9.7
45 arteriovenous fistula 9.7
46 nephrotic syndrome 9.7
47 dementia 9.7
48 acute poststreptococcal glomerulonephritis 9.7
49 status epilepticus 9.7
50 arteriosclerosis 9.7

Comorbidity relations with Hypertensive Encephalopathy via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Acute Kidney Failure
Anxiety Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Malignant Essential Hypertension Malignant Renovascular Hypertension
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypertensive Encephalopathy:



Diseases related to Hypertensive Encephalopathy

Symptoms & Phenotypes for Hypertensive Encephalopathy

MGI Mouse Phenotypes related to Hypertensive Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 ACE CYP19A1 EPO REN VLDLR

Drugs & Therapeutics for Hypertensive Encephalopathy

Drugs for Hypertensive Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antihypertensive Agents Phase 2, Phase 3
2 Peripheral Nervous System Agents Phase 2, Phase 3,Not Applicable
3 Autonomic Agents Phase 2, Phase 3,Not Applicable
4
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
5
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7 Mitogens Phase 2
8 Albumin-Bound Paclitaxel Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Endothelial Growth Factors Phase 2
12 Antibodies Phase 2
13 Immunoglobulins Phase 2
14 Antibodies, Monoclonal Phase 2
15 Antimitotic Agents Phase 2
16 Antineoplastic Agents, Phytogenic Phase 2
17
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
18 Dexamethasone acetate Not Applicable 1177-87-3
19 glucocorticoids Not Applicable
20
protease inhibitors Not Applicable
21 Gastrointestinal Agents Not Applicable
22 HIV Protease Inhibitors Not Applicable
23 Hormone Antagonists Not Applicable
24 Hormones Not Applicable
25 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
26 Antiemetics Not Applicable
27 Anti-Inflammatory Agents Not Applicable
28 BB 1101 Not Applicable
29 Antineoplastic Agents, Hormonal Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
2 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl
3 Trial of Vascular Endothelial Growth Factor (VEGF), Bevacizumab, in Combination With Cytotoxic Chemotherapy for Endometrial Cancer Completed NCT00879359 Phase 2 carboplatin, paclitaxel, and bevacizumab
4 Prognostic Observation of Posterior Reversible Encephalopathy Syndrome Unknown status NCT02665598
5 The Effect of Pre-discharge Blood Pressure of Patients With Asymptomatic Severe Hypertension in Emergency Department Completed NCT02534324 Antihypertensive meds
6 Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients Recruiting NCT03470467
7 Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES): Terminated NCT02027272 Not Applicable Dexamethasone

Search NIH Clinical Center for Hypertensive Encephalopathy

Cochrane evidence based reviews: hypertensive encephalopathy

Genetic Tests for Hypertensive Encephalopathy

Anatomical Context for Hypertensive Encephalopathy

MalaCards organs/tissues related to Hypertensive Encephalopathy:

41
Brain, Eye, Endothelial, Kidney, Spinal Cord, Neutrophil, Pons

Publications for Hypertensive Encephalopathy

Articles related to Hypertensive Encephalopathy:

(show top 50) (show all 260)
# Title Authors Year
1
New Developments in Hypertensive Encephalopathy. ( 29480370 )
2018
2
Clinical characteristics of hypertensive encephalopathy in pediatric patients. ( 29042869 )
2017
3
Hypertensive encephalopathy mimicking cerebral vasculitis with pontine oedema, cerebellar white matter lesions and multiple cerebral infarctions. ( 28724595 )
2017
4
A Case of Hypertensive Encephalopathy with Enlarged Optic Nerve Sheath Measured by Transorbital Sonography. ( 27838176 )
2017
5
'Khatatonia' - cathinone-induced hypertensive encephalopathy. ( 29256414 )
2017
6
Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula. ( 28512209 )
2017
7
Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy. ( 29284571 )
2017
8
Hypertensive Encephalopathy: A Case of a Male Who Bit Off His Fingers. ( 28979829 )
2017
9
Hypertensive Encephalopathy and Renal Failure in a Young Man. ( 26597825 )
2016
10
Hypertensive encephalopathy: what's in a name? ( 27067368 )
2016
11
Allgrove Syndrome: Adrenal Insufficiency with Hypertensive Encephalopathy. ( 27671188 )
2016
12
Does this patient have hypertensive encephalopathy? ( 26896240 )
2016
13
Acute hypertensive encephalopathy presenting with a partial third nerve palsy: image findings. ( 27932433 )
2016
14
Risk of Stroke After the International Classification of Diseases-Ninth Revision Discharge Code Diagnosis of Hypertensive Encephalopathy. ( 26742804 )
2016
15
Renal artery stenosis: An unusual etiology of hypertensive encephalopathy in a child with fanconi anemia. ( 26178556 )
2015
16
Asymmetric Posterior Reversible Encephalopathy Syndrome due to Hypertensive Encephalopathy. ( 25876591 )
2015
17
Venlafaxine as single therapy associated with hypertensive encephalopathy. ( 25763307 )
2015
18
Hypertensive encephalopathy associated with obstructive sleep apnoea syndrome. ( 25638253 )
2015
19
Increasing trend in admissions for malignant hypertension and hypertensive encephalopathy in the United States. ( 25801877 )
2015
20
Magnetic resonance imaging appearance of hypertensive encephalopathy in a dog. ( 25949801 )
2015
21
Malignant systemic hypertension, encephalopathy and bradycardia following splenectomy for hereditary spherocytosis. ( 26009599 )
2015
22
A case of Liddle's syndrome; unusual presentation with hypertensive encephalopathy. ( 24969204 )
2014
23
Hypertensive encephalopathy and cerebral infarction. ( 25932363 )
2014
24
Hypertensive encephalopathy as a late complication of autonomic dysreflexia in a 12-year-old boy with a previous spinal cord injury. ( 24535713 )
2014
25
Hypertensive encephalopathy associated with anabolic-androgenic steroids used for bodybuilding. ( 25319132 )
2014
26
Risk of subsequent dementia in patients with hypertensive encephalopathy: a nationwide population-based study in Taiwan. ( 24513673 )
2014
27
Hypertension and hypertensive encephalopathy. ( 24365295 )
2014
28
Serial MR spectroscopy in hypertensive encephalopathy. ( 25394908 )
2014
29
Estrogens are neuroprotective factors for hypertensive encephalopathy. ( 24736028 )
2014
30
Hypertensive encephalopathy with reversible brainstem edema. ( 24175031 )
2013
31
Hypertensive encephalopathy as the initial manifestation of Guillain-BarrAc syndrome in a 7-year-old girl. ( 23545616 )
2013
32
Hypertensive encephalopathy as the initial manifestation of Guillain-Barre syndrome in a 7-year-old girl. ( 23887224 )
2013
33
Concealed primary aortic sarcoma induced hypertensive encephalopathy resulting from a thoracic aortic occlusion: a case report. ( 23597173 )
2013
34
Clinicopathologic and MRI characteristics of presumptive hypertensive encephalopathy in two cats and two dogs. ( 24051253 )
2013
35
Isolated brainstem involvement in a patient with hypertensive encephalopathy. ( 23533856 )
2013
36
Characteristic electrocardiographic repolarisation changes in a 9 year-old boy with hypertensive encephalopathy. ( 23788105 )
2013
37
Severe hypertensive encephalopathy following percutaneous balloon aortic valvuloplasty for aortic stenosis. ( 24377710 )
2013
38
Risks of subsequent epilepsy among patients with hypertensive encephalopathy: a nationwide population-based study. ( 24090775 )
2013
39
Hypertensive encephalopathy following snake bite in a child: A diagnostic dilemma. ( 23983418 )
2013
40
Malignant hypertension with reversible brainstem hypertensive encephalopathy and thrombotic microangiopathy. ( 22418002 )
2012
41
Hypertensive encephalopathy presenting as status epilepticus in a three year old. ( 21903352 )
2012
42
Neuroprotection and sex steroid hormones: evidence of estradiol-mediated protection in hypertensive encephalopathy. ( 22827218 )
2012
43
Cyclophosphamide-induced hypertensive encephalopathy in a young girl with lupus. ( 22458753 )
2012
44
Hypertensive encephalopathy. ( 24665265 )
2012
45
Reversible obstructive hydrocephalus from hypertensive encephalopathy. ( 22234407 )
2012
46
Pheochromocytoma: a rare cause of childhood hypertensive encephalopathy. ( 22868025 )
2012
47
Prolonged enhancement of the subarachnoid space on FLAIR imaging in hypertensive encephalopathy. ( 21510244 )
2011
48
When should nitroglycerine be avoided in hypertensive encephalopathy? ( 21931071 )
2011
49
Accelerated kidney transplant rejection and hypertensive encephalopathy in a pediatric patient associated with antibodies against angiotensin type 1 receptor and HLA class II. ( 22067217 )
2011
50
Impressive hypertensive encephalopathy. ( 21617160 )
2011

Variations for Hypertensive Encephalopathy

Expression for Hypertensive Encephalopathy

Search GEO for disease gene expression data for Hypertensive Encephalopathy.

Pathways for Hypertensive Encephalopathy

Pathways related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 ACE REN
2 10.44 ACE REN

GO Terms for Hypertensive Encephalopathy

Cellular components related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ACE EPO REN VLDLR

Biological processes related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.32 ACE REN
2 regulation of blood pressure GO:0008217 9.26 ACE REN
3 positive regulation of protein kinase activity GO:0045860 9.16 EPO VLDLR
4 amyloid-beta metabolic process GO:0050435 8.96 ACE REN
5 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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