MCID: HYP034
MIFTS: 43

Hypertensive Encephalopathy

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Hypertensive Encephalopathy

MalaCards integrated aliases for Hypertensive Encephalopathy:

Name: Hypertensive Encephalopathy 12 54 44 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9427
ICD9CM 34 437.2
MeSH 44 D020343
NCIt 50 C3503
SNOMED-CT 67 155408008
ICD10 32 I67.4
UMLS 70 C0151620

Summaries for Hypertensive Encephalopathy

MalaCards based summary : Hypertensive Encephalopathy is related to acute diffuse nephritis and malignant hypertension. An important gene associated with Hypertensive Encephalopathy is EPO (Erythropoietin), and among its related pathways/superpathways are p70S6K Signaling and Development Angiotensin activation of ERK. Affiliated tissues include kidney, heart and eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Hypertensive encephalopathy (HE) is general brain dysfunction due to significantly high blood pressure.... more...

Related Diseases for Hypertensive Encephalopathy

Diseases related to Hypertensive Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 406)
# Related Disease Score Top Affiliating Genes
1 acute diffuse nephritis 30.2 EPO ACE
2 malignant hypertension 30.2 REN EDN1 AGTR1 ADAMTS13 ACE
3 fibromuscular dysplasia 30.2 REN AGTR1 ACE
4 papilledema 30.2 VEGFA F2 ALB ACE
5 uremia 30.2 REN EPO ALB ACE
6 thrombotic microangiopathy 30.2 VEGFA ADAMTS13
7 arteriolosclerosis 30.1 REN ALB
8 purpura 30.1 F2 ADAMTS13 ACE
9 generalized atherosclerosis 30.0 REN ALB ACE
10 chronic pyelonephritis 30.0 REN ALB ACE
11 nephrotic syndrome 30.0 REN F2 ALB ACE
12 hypokalemia 30.0 REN ALB ACE
13 hypertensive heart disease 30.0 REN AGTR1 ACE
14 pheochromocytoma 29.9 VEGFA REN EPO EDN1 ACE
15 intracranial embolism 29.9 F2 ALB ACE
16 acute kidney failure 29.9 REN F2 ALB ADAMTS13
17 severe pre-eclampsia 29.7 VEGFA PGF ALB
18 pre-eclampsia 29.6 VEGFA REN PGF FLT1 F2 EDN1
19 renal hypertension 29.5 REN EPO EDN1 ALB AGTR1 ACE
20 hypertensive retinopathy 29.4 VEGFA REN ALB AGTR1 ADAMTS13 ACE
21 thrombocytopenia 29.4 F2 EPO EDN1 ALB ADAMTS13
22 deficiency anemia 29.4 F2 EPO ALB ADAMTS13 ACE
23 cerebrovascular disease 29.4 REN F2 AGTR1 ADAMTS13 ACE
24 proteinuria, chronic benign 29.4 VEGFA REN FLT1 ALB AGTR1 ACE
25 end stage renal disease 29.3 VEGFA REN EPO ALB AGTR1 ACE
26 migraine with or without aura 1 29.3 REN F2 EDN1 ALB ACE
27 pulmonary edema 29.0 REN F2 EPO EDN1 AGTR1 ACE
28 vascular disease 28.8 VEGFA REN F2 EPO EDN1 ALB
29 eclampsia 28.8 VEGFA REN PGF FLT1 F2 EDN1
30 hypertension, essential 28.1 VEGFA REN PGF FLT1 F2 EPO
31 encephalopathy 11.1
32 glomerulonephritis 10.4
33 microvascular complications of diabetes 2 10.4 EPO ACE
34 stress polycythemia 10.4 EPO ALB
35 renal artery obstruction 10.4 REN ACE
36 hypoaldosteronism 10.4 REN ACE
37 hypertension, diastolic 10.3 REN ACE
38 glomerular disease 10.3 ALB ACE
39 potter's syndrome 10.3 REN ACE
40 posterior scleritis 10.3 VEGFA ACE
41 retinal microaneurysm 10.3 VEGFA REN
42 benign essential hypertension 10.3 REN ALB
43 arteritic anterior ischemic optic neuropathy 10.3 F2 ACE
44 granulomatous hepatitis 10.3 ALB ACE
45 acroosteolysis 10.3 VEGFA ALB
46 heart aneurysm 10.3 ALB ACE
47 hepatoportal sclerosis 10.3 F2 ACE
48 pneumoconiosis due to talc 10.3 F2 ACE
49 non-a-e hepatitis 10.3 F2 ALB
50 antipyrine metabolism 10.3 F2 ALB

Comorbidity relations with Hypertensive Encephalopathy via Phenotypic Disease Network (PDN): (show all 21)


Acute Cystitis Acute Kidney Failure
Anxiety Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Disease Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Malignant Essential Hypertension Malignant Renovascular Hypertension
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypertensive Encephalopathy:



Diseases related to Hypertensive Encephalopathy

Symptoms & Phenotypes for Hypertensive Encephalopathy

MGI Mouse Phenotypes related to Hypertensive Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ACE AGTR1 ALB EDN1 EPO F2
2 homeostasis/metabolism MP:0005376 10.15 ACE ADAMTS13 AGTR1 ALB EDN1 EPO
3 immune system MP:0005387 10.02 ACE ADAMTS13 AGTR1 ALB EPO F2
4 mortality/aging MP:0010768 9.96 ACE ADAMTS13 AGTR1 ALB EDN1 EPO
5 embryo MP:0005380 9.95 ACE EDN1 EPO F2 FLT1 PGF
6 muscle MP:0005369 9.7 ALB EDN1 EPO F2 FLT1 REN
7 normal MP:0002873 9.56 ADAMTS13 ALB EDN1 EPO F2 FLT1
8 renal/urinary system MP:0005367 9.1 ACE AGTR1 ALB EDN1 REN VEGFA

Drugs & Therapeutics for Hypertensive Encephalopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Hypertonic Saline on the Pulmonary Circulation in Children Terminated NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl

Search NIH Clinical Center for Hypertensive Encephalopathy

Cochrane evidence based reviews: hypertensive encephalopathy

Genetic Tests for Hypertensive Encephalopathy

Anatomical Context for Hypertensive Encephalopathy

MalaCards organs/tissues related to Hypertensive Encephalopathy:

40
Kidney, Heart, Eye, Brain, Thyroid, Placenta, Spinal Cord

Publications for Hypertensive Encephalopathy

Articles related to Hypertensive Encephalopathy:

(show top 50) (show all 849)
# Title Authors PMID Year
1
[Guidelines for the treatment of anemia in chronic renal failure]. 54 61
14666504 2003
2
Erythropoietin-associated hypertensive posterior leukoencephalopathy. 61 54
9305323 1997
3
Controversies in selection of epoetin dosages. Issues and answers. 54 61
7789287 1995
4
Effects of recombinant human erythropoietin on cerebral and cutaneous blood flow and on blood coagulability. 61 54
2266676 1990
5
Subcutaneous erythropoietin therapy and hypertensive encephalopathy. 61 54
2130309 1990
6
Native nephrectomy in the management of hypertension in children with kidney disease: a tool to improve blood pressure control. 61
33683431 2021
7
Neurologic Complications After Pediatric Heart Transplant: A Single-Center Experience. 61
33797352 2021
8
Neurological complications of systemic hypertension. 61
33632444 2021
9
Etiology, Diagnosis and Management of Aortitis. 61
32390100 2020
10
Hypertensive Emergency in a Woman with Systemic Sclerosis. 61
33006010 2020
11
Hypertensive emergency and seizures in a 30-year-old man with anti-glomerular basement membrane disease. 61
33363926 2020
12
[A case of meningeal melanomatosis diagnosed by immunostaining of cerebrospinal fluid]. 61
32641630 2020
13
Hypertensive emergencies and urgencies in emergency departments: a systematic review and meta-analysis. 61
32510905 2020
14
Successful treatment of refractory acute lupus haemophagocytic syndrome using rituximab: a case report. 61
33087000 2020
15
Seizure and coma secondary to Conn's syndrome: a case report. 61
32665023 2020
16
CASPR2 autoimmunity in children expanding to mild encephalopathy with hypertension. 61
32424051 2020
17
Blood pressure and the brain: the neurology of hypertension. 61
31558584 2020
18
[Malignant arterial hypertension (HTAM) with severe systolic dysfunction of the reversible left ventricle]. 61
31735701 2020
19
Cerebral Hyperperfusion Syndrome and Related Conditions. 61
33070131 2020
20
Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model. 61
33644125 2020
21
[Features of cerebral venous hemodynamic in patients with hypertensive encephalopathy]. 61
32621466 2020
22
Posterior Reversible Encephalopathy Syndrome: Pattern on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Correlated with Magnetic Resonance Imaging in Pediatric Hypertensive Encephalopathy. 61
31949377 2020
23
Case Report: Posterior Reversible Leukoencephalopathy Syndrome (PRES) as a Biologically Predictable Neurological Association in Severe COVID-19. First Reported Case From Australia and Review of Internationally Published Cases. 61
33584499 2020
24
Mid-Aortic Syndrome: A Rare Cause of Renovascular Hypertension in Childhood Treated Percutaneously with an Unusual Vascular Access. 61
32516103 2020
25
Clinical Profile and Immediate Outcome of Children Admitted With Acute Glomerulonephritis in Pediatrics Department of A Tertiary Level Hospital. 61
31915329 2020
26
Clinical and MRI Features of Posterior Reversible Encephalopathy Syndrome With Atypical Regions: A Descriptive Study With a Large Sample Size. 61
32265829 2020
27
Posterior Reversible Encephalopathy Syndrome Due to Acute Water Intoxication in a Patient with Schizophrenia. 61
32308504 2020
28
Hypertensive brainstem encephalopathy: a diagnosis often overlooked. 61
31732595 2019
29
Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. 61
31402321 2019
30
Posterior reversible encephalopathy syndrome: A review with emphasis on neuroimaging characteristics. 61
31349066 2019
31
Neuropathology of Spontaneous Hypertensive Encephalopathy in Cats. 61
31113291 2019
32
Hypertension and Stroke: Update on Treatment. 61
31360232 2019
33
A novel mutation in the glucocorticoid receptor gene as a cause of severe glucocorticoid resistance complicated by hypertensive encephalopathy. 61
31145715 2019
34
Unusual presentation of primary aldosteronism with advanced target organ damage: A case report. 61
31024637 2019
35
Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy. 61
30117098 2019
36
Status epilepticus in black African patients with hypertensive encephalopathy: a rare entity that must not be underrated. 61
31379343 2019
37
Requirement for Head Magnetic Resonance Imaging in Children Who Present to the Emergency Department With Acute Nontraumatic Visual Disturbance. 61
29768295 2019
38
Isolated pontine involvement in posterior reversible encephalopathy syndrome with coincidental acute ischaemic stroke. 61
30996063 2019
39
End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency. 61
30838168 2019
40
YangXue QingNao Wan, a Compound Chinese Medicine, Attenuates Cerebrovascular Hyperpermeability and Neuron Injury in Spontaneously Hypertensive Rat: Effect and Mechanism. 61
31632292 2019
41
Hypertensive emergency presenting with acute spontaneous subdural hematoma. 61
30693055 2019
42
Posterior Reversible Encephalopathy Syndrome Secondary to Hypertensive Encephalopathy Brought on by a MAO Inhibitor: A Case Report. 61
31423884 2019
43
[Mycophenolate mofetil versus cyclosporine A in children with primary refractory nephrotic syndrome]. 61
30180402 2018
44
A Late Complication Occurring Due to Tacrolimus After Liver Transplant: Posterior Reversible Encephalopathy Syndrome. 61
29993355 2018
45
Trastuzumab-associated Posterior Reversible Encephalopathy Syndrome. 61
30050741 2018
46
Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy. 61
29284571 2018
47
In Response to: De Bernardo, M and Rosa, N. "Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy". 61
29395651 2018
48
Congenital adrenal hyperplasia due to 17-alpha hydroxylase deficiency with hypertensive encephalopathy, hypoglycemic seizures and adrenal insufficiency. 61
30104848 2018
49
Durable renal response after combination of bortezomib, corticosteroids, rituximab, and plasmapheresis for late antibody-mediated renal transplant rejection
. 61
29208204 2018
50
New Developments in Hypertensive Encephalopathy. 61
29480370 2018

Variations for Hypertensive Encephalopathy

Expression for Hypertensive Encephalopathy

Search GEO for disease gene expression data for Hypertensive Encephalopathy.

Pathways for Hypertensive Encephalopathy

Pathways related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 REN PGF FLT1 F2 AGTR1 ACE
2
Show member pathways
12.59 F2 EPO EDN1 AGTR1
3 12.46 VEGFA PGF F2 EPO EDN1 AGTR1
4 11.69 VEGFA EDN1 AGTR1
5 11.66 VEGFA FLT1 EPO EDN1
6
Show member pathways
11.63 VEGFA PGF FLT1
7 11.47 VEGFA EPO EDN1
8 11.37 VEGFA EPO EDN1
9
Show member pathways
11.16 REN NLN AGTR1 ACE
10 11.15 VEGFA EPO EDN1
11 11.08 VEGFA FLT1 EPO
12 10.92 VEGFA FLT1
13 10.76 REN EDN1 AGTR1 ACE
14
Show member pathways
10.54 VEGFA PGF FLT1

GO Terms for Hypertensive Encephalopathy

Cellular components related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 VEGFA REN PGF FLT1 F2 EPO
2 extracellular region GO:0005576 9.36 VEGFA REN PGF NLN FLT1 F2

Biological processes related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.93 REN NLN F2 ADAMTS13 ACE
2 positive regulation of angiogenesis GO:0045766 9.77 VEGFA PGF FLT1
3 regulation of blood pressure GO:0008217 9.7 REN EDN1 ACE
4 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.69 VEGFA PGF FLT1
5 response to hypoxia GO:0001666 9.67 VEGFA PGF EPO EDN1
6 positive regulation of MAP kinase activity GO:0043406 9.63 VEGFA FLT1 EDN1
7 positive regulation of cell proliferation GO:0008284 9.63 VEGFA PGF FLT1 F2 EPO EDN1
8 kidney development GO:0001822 9.62 VEGFA REN AGTR1 ACE
9 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.61 VEGFA AGTR1
10 regulation of blood vessel diameter GO:0097746 9.6 AGTR1 ACE
11 peptide catabolic process GO:0043171 9.58 ADAMTS13 ACE
12 induction of positive chemotaxis GO:0050930 9.58 VEGFA PGF
13 amyloid-beta metabolic process GO:0050435 9.57 REN ACE
14 angiotensin maturation GO:0002003 9.56 REN ACE
15 response to dexamethasone GO:0071548 9.55 EPO EDN1
16 positive regulation of mast cell chemotaxis GO:0060754 9.49 VEGFA PGF
17 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.48 AGTR1 ACE
18 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.43 VEGFA ACE
19 regulation of vasoconstriction GO:0019229 9.43 EDN1 AGTR1 ACE
20 renin-angiotensin regulation of aldosterone production GO:0002018 9.4 REN AGTR1
21 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 VEGFA FLT1 F2 EPO
22 vascular endothelial growth factor signaling pathway GO:0038084 8.8 VEGFA PGF FLT1

Molecular functions related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 VEGFA PGF F2
2 endopeptidase activity GO:0004175 9.43 REN ADAMTS13 ACE
3 peptidase activity GO:0008233 9.35 REN NLN F2 ADAMTS13 ACE
4 vascular endothelial growth factor receptor binding GO:0005172 9.16 VEGFA PGF
5 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Hypertensive Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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