MCID: HYP034
MIFTS: 38

Hypertensive Encephalopathy

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Hypertensive Encephalopathy

MalaCards integrated aliases for Hypertensive Encephalopathy:

Name: Hypertensive Encephalopathy 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9427
ICD10 33 I67.4
ICD9CM 35 437.2
MeSH 44 D020343
NCIt 50 C3503
SNOMED-CT 68 50490005
UMLS 73 C0151620

Summaries for Hypertensive Encephalopathy

MalaCards based summary : Hypertensive Encephalopathy is related to malignant hypertension and stroke, ischemic. An important gene associated with Hypertensive Encephalopathy is EPO (Erythropoietin), and among its related pathways/superpathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin secretion. The drugs Antihypertensive Agents and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Hypertensive encephalopathy (HE) is general brain dysfunction due to significantly high blood pressure.... more...

Related Diseases for Hypertensive Encephalopathy

Diseases related to Hypertensive Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 30.2 ACE REN
2 stroke, ischemic 29.4 ACE DCX REN
3 lipoid congenital adrenal hyperplasia 29.3 CYP19A1 REN
4 renal hypertension 29.3 ACE EPO REN
5 encephalopathy 10.9
6 hypersensitivity vasculitis 10.1 ACE SLC26A5
7 headache 10.1
8 lissencephaly 10.1 DCX VLDLR
9 lissencephaly with cerebellar hypoplasia 10.1 DCX VLDLR
10 cerebellar hypoplasia 10.1 DCX VLDLR
11 neuronal migration disorders 10.1 DCX VLDLR
12 diabetic neuropathy 10.1 ACE EPO
13 eclampsia 10.0
14 myoma 10.0 CYP19A1 EPO
15 end stage renal failure 10.0 ACE EPO
16 glomerulonephritis 10.0
17 hyporeninemic hypoaldosteronism 10.0 ACE REN
18 hypoaldosteronism 10.0 ACE REN
19 renal artery obstruction 10.0 ACE REN
20 hypertension, diastolic 9.9 ACE REN
21 hypertensive retinopathy 9.9 ACE REN
22 orthostatic proteinuria 9.9 ACE REN
23 malignant essential hypertension 9.9 ACE REN
24 anuria 9.9 ACE REN
25 hydrocephalus 9.9
26 fibromuscular dysplasia 9.9 ACE REN
27 hepatorenal syndrome 9.9 ACE REN
28 renal tubular dysgenesis 9.9 ACE REN
29 renovascular hypertension 9.9 ACE REN
30 pseudohyperkalemia, familial, 2, due to red cell leak 9.9 ACE REN
31 interstitial nephritis 9.9 ACE REN
32 heart valve disease 9.9 ACE REN
33 obstructive nephropathy 9.9 ACE REN
34 oligohydramnios 9.9 ACE REN
35 carotid artery disease 9.9 ACE REN
36 hypokalemia 9.9 ACE REN
37 pulmonary edema 9.9 ACE REN
38 renal dysplasia 9.9 ACE REN
39 ovarian hyperstimulation syndrome 9.9 CYP19A1 REN
40 iga glomerulonephritis 9.9 ACE REN
41 aortic valve disease 2 9.9 ACE REN
42 pheochromocytoma 9.8
43 polyarteritis nodosa, childhood-onset 9.8
44 arteriovenous fistula 9.8
45 nephrotic syndrome 9.8
46 dementia 9.8
47 acute poststreptococcal glomerulonephritis 9.8
48 status epilepticus 9.8
49 epilepsy 9.8
50 arteriosclerosis 9.8

Comorbidity relations with Hypertensive Encephalopathy via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Acute Kidney Failure
Anxiety Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Malignant Essential Hypertension Malignant Renovascular Hypertension
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypertensive Encephalopathy:



Diseases related to Hypertensive Encephalopathy

Symptoms & Phenotypes for Hypertensive Encephalopathy

MGI Mouse Phenotypes related to Hypertensive Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 ACE CYP19A1 EPO REN VLDLR
2 growth/size/body region MP:0005378 9.1 ACE CYP19A1 DCX REN SLC26A5 VLDLR

Drugs & Therapeutics for Hypertensive Encephalopathy

Drugs for Hypertensive Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antihypertensive Agents Phase 2, Phase 3
2 Peripheral Nervous System Agents Phase 2, Phase 3,Not Applicable
3 Autonomic Agents Phase 2, Phase 3,Not Applicable
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
7 Antineoplastic Agents, Phytogenic Phase 2
8 Angiogenesis Inhibitors Phase 2
9 Immunoglobulins Phase 2
10 Endothelial Growth Factors Phase 2
11 Antimitotic Agents Phase 2
12 Mitogens Phase 2
13 Angiogenesis Modulating Agents Phase 2
14 Antibodies Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Antibodies, Monoclonal Phase 2
17
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
18
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
19 Antineoplastic Agents, Hormonal Not Applicable
20 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
21
protease inhibitors Not Applicable
22 Hormones Not Applicable
23 Hormone Antagonists Not Applicable
24 HIV Protease Inhibitors Not Applicable
25 Antiemetics Not Applicable
26 glucocorticoids Not Applicable
27 Gastrointestinal Agents Not Applicable
28 BB 1101 Not Applicable
29 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
2 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl
3 Trial of Vascular Endothelial Growth Factor (VEGF), Bevacizumab, in Combination With Cytotoxic Chemotherapy for Endometrial Cancer Completed NCT00879359 Phase 2 carboplatin, paclitaxel, and bevacizumab
4 Prognostic Observation of Posterior Reversible Encephalopathy Syndrome Unknown status NCT02665598
5 The Effect of Pre-discharge Blood Pressure of Patients With Asymptomatic Severe Hypertension in Emergency Department Completed NCT02534324 Antihypertensive meds
6 Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients Recruiting NCT03470467
7 Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES): Terminated NCT02027272 Not Applicable Dexamethasone

Search NIH Clinical Center for Hypertensive Encephalopathy

Cochrane evidence based reviews: hypertensive encephalopathy

Genetic Tests for Hypertensive Encephalopathy

Anatomical Context for Hypertensive Encephalopathy

MalaCards organs/tissues related to Hypertensive Encephalopathy:

41
Brain, Eye, Endothelial, Kidney, Spinal Cord, Temporal Lobe, Heart

Publications for Hypertensive Encephalopathy

Articles related to Hypertensive Encephalopathy:

(show top 50) (show all 272)
# Title Authors Year
1
New Developments in Hypertensive Encephalopathy. ( 29480370 )
2018
2
In Response to: De Bernardo, M and Rosa, N. "Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy". ( 29395651 )
2018
3
Congenital adrenal hyperplasia due to 17-alpha hydroxylase deficiency with hypertensive encephalopathy, hypoglycemic seizures and adrenal insufficiency. ( 30104848 )
2018
4
Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy. ( 30117098 )
2018
5
Clinical characteristics of hypertensive encephalopathy in pediatric patients. ( 29042869 )
2017
6
Hypertensive encephalopathy mimicking cerebral vasculitis with pontine oedema, cerebellar white matter lesions and multiple cerebral infarctions. ( 28724595 )
2017
7
A Case of Hypertensive Encephalopathy with Enlarged Optic Nerve Sheath Measured by Transorbital Sonography. ( 27838176 )
2017
8
'Khatatonia' - cathinone-induced hypertensive encephalopathy. ( 29256414 )
2017
9
Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula. ( 28512209 )
2017
10
Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy. ( 29284571 )
2017
11
Hypertensive Encephalopathy: A Case of a Male Who Bit Off His Fingers. ( 28979829 )
2017
12
Hypertensive Encephalopathy and Renal Failure in a Young Man. ( 26597825 )
2016
13
Hypertensive encephalopathy: what's in a name? ( 27067368 )
2016
14
Allgrove Syndrome: Adrenal Insufficiency with Hypertensive Encephalopathy. ( 27671188 )
2016
15
Does this patient have hypertensive encephalopathy? ( 26896240 )
2016
16
Acute hypertensive encephalopathy presenting with a partial third nerve palsy: image findings. ( 27932433 )
2016
17
Risk of Stroke After the International Classification of Diseases-Ninth Revision Discharge Code Diagnosis of Hypertensive Encephalopathy. ( 26742804 )
2016
18
Renal artery stenosis: An unusual etiology of hypertensive encephalopathy in a child with fanconi anemia. ( 26178556 )
2015
19
Asymmetric Posterior Reversible Encephalopathy Syndrome due to Hypertensive Encephalopathy. ( 25876591 )
2015
20
Venlafaxine as single therapy associated with hypertensive encephalopathy. ( 25763307 )
2015
21
Hypertensive encephalopathy associated with obstructive sleep apnoea syndrome. ( 25638253 )
2015
22
Increasing trend in admissions for malignant hypertension and hypertensive encephalopathy in the United States. ( 25801877 )
2015
23
Magnetic resonance imaging appearance of hypertensive encephalopathy in a dog. ( 25949801 )
2015
24
Estrogens are neuroprotective factors for hypertensive encephalopathy. ( 24736028 )
2015
25
A case of Liddle's syndrome; unusual presentation with hypertensive encephalopathy. ( 24969204 )
2014
26
Hypertensive encephalopathy and cerebral infarction. ( 25932363 )
2014
27
Hypertensive encephalopathy as a late complication of autonomic dysreflexia in a 12-year-old boy with a previous spinal cord injury. ( 24535713 )
2014
28
Hypertensive encephalopathy associated with anabolic-androgenic steroids used for bodybuilding. ( 25319132 )
2014
29
Risk of subsequent dementia in patients with hypertensive encephalopathy: a nationwide population-based study in Taiwan. ( 24513673 )
2014
30
Hypertension and hypertensive encephalopathy. ( 24365295 )
2014
31
Serial MR spectroscopy in hypertensive encephalopathy. ( 25394908 )
2014
32
Hypertensive encephalopathy with reversible brainstem edema. ( 24175031 )
2013
33
Hypertensive encephalopathy as the initial manifestation of Guillain-BarrAc syndrome in a 7-year-old girl. ( 23545616 )
2013
34
Hypertensive encephalopathy as the initial manifestation of Guillain-Barre syndrome in a 7-year-old girl. ( 23887224 )
2013
35
Concealed primary aortic sarcoma induced hypertensive encephalopathy resulting from a thoracic aortic occlusion: a case report. ( 23597173 )
2013
36
Clinicopathologic and MRI characteristics of presumptive hypertensive encephalopathy in two cats and two dogs. ( 24051253 )
2013
37
Isolated brainstem involvement in a patient with hypertensive encephalopathy. ( 23533856 )
2013
38
Characteristic electrocardiographic repolarisation changes in a 9 year-old boy with hypertensive encephalopathy. ( 23788105 )
2013
39
Severe hypertensive encephalopathy following percutaneous balloon aortic valvuloplasty for aortic stenosis. ( 24377710 )
2013
40
Risks of subsequent epilepsy among patients with hypertensive encephalopathy: a nationwide population-based study. ( 24090775 )
2013
41
Hypertensive encephalopathy following snake bite in a child: A diagnostic dilemma. ( 23983418 )
2013
42
Malignant hypertension with reversible brainstem hypertensive encephalopathy and thrombotic microangiopathy. ( 22418002 )
2012
43
Hypertensive encephalopathy presenting as status epilepticus in a three year old. ( 21903352 )
2012
44
Neuroprotection and sex steroid hormones: evidence of estradiol-mediated protection in hypertensive encephalopathy. ( 22827218 )
2012
45
Cyclophosphamide-induced hypertensive encephalopathy in a young girl with lupus. ( 22458753 )
2012
46
Hypertensive encephalopathy. ( 24665265 )
2012
47
Reversible obstructive hydrocephalus from hypertensive encephalopathy. ( 22234407 )
2012
48
Pheochromocytoma: a rare cause of childhood hypertensive encephalopathy. ( 22868025 )
2012
49
Prolonged enhancement of the subarachnoid space on FLAIR imaging in hypertensive encephalopathy. ( 21510244 )
2011
50
When should nitroglycerine be avoided in hypertensive encephalopathy? ( 21931071 )
2011

Variations for Hypertensive Encephalopathy

Expression for Hypertensive Encephalopathy

Search GEO for disease gene expression data for Hypertensive Encephalopathy.

Pathways for Hypertensive Encephalopathy

Pathways related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.06 ACE REN
2 10.77 ACE REN
3 10.11 DCX VLDLR

GO Terms for Hypertensive Encephalopathy

Biological processes related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.37 ACE REN
2 regulation of blood pressure GO:0008217 9.32 ACE REN
3 positive regulation of protein kinase activity GO:0045860 9.26 EPO VLDLR
4 dendrite morphogenesis GO:0048813 9.16 DCX VLDLR
5 amyloid-beta metabolic process GO:0050435 8.96 ACE REN
6 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....