MCID: HYP034
MIFTS: 45

Hypertensive Encephalopathy

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Hypertensive Encephalopathy

MalaCards integrated aliases for Hypertensive Encephalopathy:

Name: Hypertensive Encephalopathy 12 54 43 15 17 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9427
ICD9CM 34 437.2
MeSH 43 D020343
NCIt 49 C3503
SNOMED-CT 67 50490005
ICD10 32 I67.4
UMLS 71 C0151620

Summaries for Hypertensive Encephalopathy

MalaCards based summary : Hypertensive Encephalopathy is related to hydrops, lactic acidosis, and sideroblastic anemia and malignant hypertension. An important gene associated with Hypertensive Encephalopathy is EPO (Erythropoietin), and among its related pathways/superpathways are p70S6K Signaling and Pathways in cancer. The drugs Perindopril and Lisinopril have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 74 Hypertensive encephalopathy (HE) is general brain dysfunction due to significantly high blood pressure.... more...

Related Diseases for Hypertensive Encephalopathy

Diseases related to Hypertensive Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 hydrops, lactic acidosis, and sideroblastic anemia 30.9 VEGFA ALB
2 malignant hypertension 30.4 REN AGTR1 ADAMTS13 ACE
3 pre-eclampsia 30.1 VEGFA REN PGF F2 ALB AGTR1
4 hypokalemia 30.1 REN ALB ACE
5 fibromuscular dysplasia 30.0 REN AGTR1 ACE
6 thrombotic microangiopathy 30.0 VEGFA ADAMTS13
7 uremia 30.0 REN EPO ALB ACE
8 generalized atherosclerosis 29.9 REN ALB ACE
9 pheochromocytoma 29.9 VEGFA REN EPO ACE
10 chronic pyelonephritis 29.9 REN ALB ACE
11 intracranial embolism 29.9 F2 ACE
12 arteriolosclerosis 29.8 REN ALB
13 purpura 29.8 F2 ADAMTS13 ACE
14 hypertensive heart disease 29.8 REN AGTR1 ACE
15 papilledema 29.7 VEGFA F2 ALB ACE
16 renal hypertension 29.5 REN EPO ALB AGTR1 ACE
17 deficiency anemia 29.4 EPO ALB ADAMTS13 ACE
18 severe pre-eclampsia 29.3 VEGFA PGF ALB
19 pyelonephritis 29.3 PGF ALB ACE
20 acute kidney failure 29.1 REN F2 CABIN1 ALB ADAMTS13
21 end stage renal failure 29.1 REN EPO ALB AGTR1 ACE
22 pulmonary edema 29.0 REN F2 EPO AGTR1 ACE
23 chronic kidney disease 28.9 VEGFA REN EPO ALB AGTR1 ACE
24 cerebrovascular disease 28.8 REN F2 AGTR1 ADAMTS13 ACE
25 vascular disease 28.8 VEGFA REN F2 EPO ALB ACE
26 hypertensive retinopathy 28.8 VEGFA REN ALB AGTR1 ADAMTS13 ACE
27 kidney disease 28.7 VEGFA REN EPO CABIN1 ALB AGTR1
28 stroke, ischemic 28.4 REN F2 ALB AGTR1 ADAMTS13 ACE
29 eclampsia 28.2 VEGFA REN PGF F2 ALB AGTR1
30 hypertension, essential 27.7 VEGFA REN PGF F2 EPO ALB
31 encephalopathy 11.0
32 hypoaldosteronism 10.5 REN ACE
33 renal artery obstruction 10.5 REN ACE
34 hypertension, diastolic 10.4 REN ACE
35 potter's syndrome 10.4 REN ACE
36 polycystic kidney disease 4 10.4 REN ALB
37 iritis 10.4 EPO ACE
38 idiopathic nephrotic syndrome 10.4 ALB ACE
39 glomerular disease 10.4 ALB ACE
40 retinal microaneurysm 10.4 VEGFA REN
41 malignant secondary hypertension 10.4 REN AGTR1
42 balantidiasis 10.3 EPO ALB
43 granulomatous hepatitis 10.3 ALB ACE
44 glomerulonephritis 10.3
45 headache 10.3
46 chronic mountain sickness 10.3 VEGFA EPO
47 spinal cord lymphoma 10.3 SLC26A5 CABIN1
48 red cell aplasia 10.3 EPO ALB
49 pure autonomic failure 10.3 REN EPO ACE
50 lymphocele 10.3 CABIN1 ALB

Comorbidity relations with Hypertensive Encephalopathy via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Acute Kidney Failure
Anxiety Benign Essential Hypertension
Cerebral Atherosclerosis Cerebrovascular Disease
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Malignant Essential Hypertension
Malignant Renovascular Hypertension Peripheral Vascular Disease
Renal Artery Atheroma Respiratory Failure
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Hypertensive Encephalopathy:



Diseases related to Hypertensive Encephalopathy

Symptoms & Phenotypes for Hypertensive Encephalopathy

MGI Mouse Phenotypes related to Hypertensive Encephalopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 ACE AGTR1 ALB EPO F2 PGF
2 hematopoietic system MP:0005397 9.91 ACE ADAMTS13 AGTR1 CABIN1 EPO F2
3 homeostasis/metabolism MP:0005376 9.85 ACE ADAMTS13 AGTR1 ALB EPO F2
4 immune system MP:0005387 9.7 ACE ADAMTS13 AGTR1 ALB CABIN1 EPO
5 renal/urinary system MP:0005367 9.1 ACE AGTR1 ALB MMACHC REN VEGFA

Drugs & Therapeutics for Hypertensive Encephalopathy

Drugs for Hypertensive Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
2
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
3
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
4
protease inhibitors Phase 4
5 HIV Protease Inhibitors Phase 4
6 Angiotensin-Converting Enzyme Inhibitors Phase 4
7 Epoetin alfa Phase 4 113427-24-0
8 Iron Supplement Phase 4
9
Bevacizumab Approved, Investigational Phase 2 216974-75-3
10
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
11
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
12
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
13
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
14 Antineoplastic Agents, Immunological Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Antimitotic Agents Phase 2
17 Antibodies, Monoclonal Phase 2
18 Endothelial Growth Factors Phase 2
19 Mitogens Phase 2
20 Immunoglobulins Phase 2
21 Antibodies Phase 2
22 Albumin-Bound Paclitaxel Phase 1, Phase 2
23 Etoposide phosphate Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Angiotensin Converting Enzyme Inhibitors on Peritoneal Protein Loss and Solute Transport in Peritoneal Dialysis Patients Completed NCT01575652 Phase 4
2 A Study on the Effect of Hemoglobin Level and the Vascular Reactivity Using th Generic Erythropoeitin Alpha (Renogen) on Incident Peritoneal Dialysis Patients Completed NCT03286712 Phase 4 Renogen
3 Labetalol Versus MgSO4 for the Prevention of Eclampsia Trial (LAMPET) Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
4 Phase II Trial of Geriatric Evaluation as Selection Criteria and Predictive Factor of Safety in Elderly Patients (≥ 70 Years) With Non-small Cell Lung Cancer (NSCLC)That Can be Treated With Bevacizumab, Carboplatin and Paclitaxel Unknown status NCT01980472 Phase 2
5 A Phase II Trial of a Vascular Endothelial Growth Factor (VEGF) Monoclonal Antibody, AVASTIN, in Combination With Cytotoxic Chemotherapy CARBOPLATIN and PACLITAXEL for Recurrent/Advanced Endometrial Cancer Completed NCT00879359 Phase 2 carboplatin, paclitaxel, and bevacizumab
6 Phase I / II Clinical Study on the Safety and Preliminary Efficacy of Anlotinib Hydrochloride Combined With Platinum-containing Simultaneous Radiotherapy in the Treatment of Locally Advanced Non-small Cell Lung Cancer Recruiting NCT04182698 Phase 1, Phase 2 Simultaneous chemoradiotherapy for An Luo
7 Prognostic Observation of Posterior Reversible Encephalopathy Syndrome Unknown status NCT02665598
8 Predicting Response and Toxicity in Patients Receiving Paclitaxel and Avastin for Breast Cancer: A Multicenter Genomic, Proteomic and Pharmacogenomic Correlative Study Terminated NCT00537173 Paclitaxel;Avastin

Search NIH Clinical Center for Hypertensive Encephalopathy

Cochrane evidence based reviews: hypertensive encephalopathy

Genetic Tests for Hypertensive Encephalopathy

Anatomical Context for Hypertensive Encephalopathy

MalaCards organs/tissues related to Hypertensive Encephalopathy:

40
Brain, Kidney, Heart, Eye, Spinal Cord, Lung, Endothelial

Publications for Hypertensive Encephalopathy

Articles related to Hypertensive Encephalopathy:

(show top 50) (show all 827)
# Title Authors PMID Year
1
[Guidelines for the treatment of anemia in chronic renal failure]. 54 61
14666504 2003
2
Erythropoietin-associated hypertensive posterior leukoencephalopathy. 54 61
9305323 1997
3
Controversies in selection of epoetin dosages. Issues and answers. 54 61
7789287 1995
4
Effects of recombinant human erythropoietin on cerebral and cutaneous blood flow and on blood coagulability. 54 61
2266676 1990
5
Subcutaneous erythropoietin therapy and hypertensive encephalopathy. 54 61
2130309 1990
6
Posterior Reversible Encephalopathy Syndrome: Pattern on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Correlated with Magnetic Resonance Imaging in Pediatric Hypertensive Encephalopathy. 61
31949377 2020
7
Clinical Profile and Immediate Outcome of Children Admitted With Acute Glomerulonephritis in Pediatrics Department of A Tertiary Level Hospital. 61
31915329 2020
8
Hypertensive brainstem encephalopathy: a diagnosis often overlooked. 61
31732595 2019
9
[Malignant arterial hypertension (HTAM) with severe systolic dysfunction of the reversible left ventricle]. 61
31735701 2019
10
Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. 61
31402321 2019
11
Posterior reversible encephalopathy syndrome: A review with emphasis on neuroimaging characteristics. 61
31349066 2019
12
Blood pressure and the brain: the neurology of hypertension. 61
31558584 2019
13
Neuropathology of Spontaneous Hypertensive Encephalopathy in Cats. 61
31113291 2019
14
Hypertension and Stroke: Update on Treatment. 61
31360232 2019
15
A novel mutation in the glucocorticoid receptor gene as a cause of severe glucocorticoid resistance complicated by hypertensive encephalopathy. 61
31145715 2019
16
Unusual presentation of primary aldosteronism with advanced target organ damage: A case report. 61
31024637 2019
17
Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy. 61
30117098 2019
18
Status epilepticus in black African patients with hypertensive encephalopathy: a rare entity that must not be underrated. 61
31379343 2019
19
Requirement for Head Magnetic Resonance Imaging in Children Who Present to the Emergency Department With Acute Nontraumatic Visual Disturbance. 61
29768295 2019
20
Isolated pontine involvement in posterior reversible encephalopathy syndrome with coincidental acute ischaemic stroke. 61
30996063 2019
21
Hypertensive emergency presenting with acute spontaneous subdural hematoma. 61
30693055 2019
22
YangXue QingNao Wan, a Compound Chinese Medicine, Attenuates Cerebrovascular Hyperpermeability and Neuron Injury in Spontaneously Hypertensive Rat: Effect and Mechanism. 61
31632292 2019
23
End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency. 61
30838168 2019
24
Posterior Reversible Encephalopathy Syndrome Secondary to Hypertensive Encephalopathy Brought on by a MAO Inhibitor: A Case Report. 61
31423884 2019
25
[Mycophenolate mofetil versus cyclosporine A in children with primary refractory nephrotic syndrome]. 61
30180402 2018
26
A Late Complication Occurring Due to Tacrolimus After Liver Transplant: Posterior Reversible Encephalopathy Syndrome. 61
29993355 2018
27
Trastuzumab-associated Posterior Reversible Encephalopathy Syndrome. 61
30050741 2018
28
In Response to: De Bernardo, M and Rosa, N. "Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy". 61
29395651 2018
29
Transorbital Sonography to Evaluate Optic Nerve in Hypertensive Encephalopathy. 61
29284571 2018
30
Congenital adrenal hyperplasia due to 17-alpha hydroxylase deficiency with hypertensive encephalopathy, hypoglycemic seizures and adrenal insufficiency. 61
30104848 2018
31
Durable renal response after combination of bortezomib, corticosteroids, rituximab, and plasmapheresis for late antibody-mediated renal transplant rejection
. 61
29208204 2018
32
New Developments in Hypertensive Encephalopathy. 61
29480370 2018
33
Posterior Reversible Encephalopathy Syndrome Associated with Sorafenib and Successful Retreatment. 61
26845702 2018
34
Posterior Reversible Encephalopathy Syndrome With Isolated Involving Infratentorial Structures. 61
30356684 2018
35
'Khatatonia' - cathinone-induced hypertensive encephalopathy. 61
29256414 2017
36
Clinical characteristics of hypertensive encephalopathy in pediatric patients. 61
29042869 2017
37
Venous hypertensive encephalopathy secondary to venous sinus thrombosis and dural arteriovenous fistula. 61
28512209 2017
38
Hypertensive encephalopathy mimicking cerebral vasculitis with pontine oedema, cerebellar white matter lesions and multiple cerebral infarctions. 61
28724595 2017
39
Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats. 61
28523794 2017
40
Hypertensive Encephalopathy: A Case of a Male Who Bit Off His Fingers. 61
28979829 2017
41
Clinical Profile of Hypertensive Emergencies in an Intensive Care Unit. 61
28598043 2017
42
Towards developing criteria for scleroderma renal crisis: A scoping review. 61
28212921 2017
43
Pazopanib induced unilateral posterior reversible encephalopathy syndrome. 61
29870619 2017
44
Clinical Characteristics of Transplant-associated Encephalopathy in Children. 61
28145649 2017
45
Various Imaging Manifestations of Posterior Reversible Encephalopathy Syndrome (PRES) on Magnetic Resonance Imaging (MRI). 61
28243339 2017
46
A Case of Hypertensive Encephalopathy with Enlarged Optic Nerve Sheath Measured by Transorbital Sonography. 61
27838176 2017
47
Acute hypertensive encephalopathy presenting with a partial third nerve palsy: image findings. 61
27932433 2016
48
APPLICATION OF PHARMACEUTICAL KNOWLEDGE TO THE UNCONVENTIONAL USE OF A RARELY USED ANAESTHETIC AGENT. 61
27540247 2016
49
Allgrove Syndrome: Adrenal Insufficiency with Hypertensive Encephalopathy. 61
27671188 2016
50
A Population-Based Analysis of Outcomes in Patients With a Primary Diagnosis of Hypertension in the Emergency Department. 61
27395439 2016

Variations for Hypertensive Encephalopathy

Expression for Hypertensive Encephalopathy

Search GEO for disease gene expression data for Hypertensive Encephalopathy.

Pathways for Hypertensive Encephalopathy

Pathways related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 REN PGF F2 AGTR1 ACE
2 11.75 VEGFA PGF F2 EPO AGTR1
3
Show member pathways
11.23 REN AGTR1 ACE
4 10.97 REN AGTR1 ACE
5
Show member pathways
10.46 VEGFA PGF

GO Terms for Hypertensive Encephalopathy

Cellular components related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 VEGFA REN PGF F2 EPO ALB
2 extracellular space GO:0005615 9.23 VEGFA REN PGF F2 EPO ALB

Biological processes related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell shape GO:0008360 9.72 VEGFA SLC26A5 F2
2 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.54 VEGFA AGTR1
3 regulation of vasoconstriction GO:0019229 9.52 AGTR1 ACE
4 regulation of blood vessel diameter GO:0097746 9.51 AGTR1 ACE
5 peptide catabolic process GO:0043171 9.49 ADAMTS13 ACE
6 vascular endothelial growth factor signaling pathway GO:0038084 9.48 VEGFA PGF
7 amyloid-beta metabolic process GO:0050435 9.46 REN ACE
8 induction of positive chemotaxis GO:0050930 9.43 VEGFA PGF
9 angiotensin maturation GO:0002003 9.4 REN ACE
10 positive regulation of mast cell chemotaxis GO:0060754 9.37 VEGFA PGF
11 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.32 AGTR1 ACE
12 response to potassium ion GO:0035864 9.26 SLC26A5 ADAMTS13
13 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.16 VEGFA ACE
14 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 REN AGTR1
15 kidney development GO:0001822 8.92 VEGFA REN AGTR1 ACE

Molecular functions related to Hypertensive Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor binding GO:0005172 8.96 VEGFA PGF
2 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Hypertensive Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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