MCID: HYP006
MIFTS: 50

Hypertensive Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Hypertensive Heart Disease

MalaCards integrated aliases for Hypertensive Heart Disease:

Name: Hypertensive Heart Disease 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11516
ICD10 33 I11 I11.9 I11.0
ICD9CM 35 402 402.9
UMLS 73 C0152105

Summaries for Hypertensive Heart Disease

Disease Ontology : 12 A heart disease that is caused by high blood pressure.

MalaCards based summary : Hypertensive Heart Disease is related to heart disease and nephrosclerosis. An important gene associated with Hypertensive Heart Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Pathways in cancer and Colorectal Cancer Metastasis. The drugs Angiotensin II and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Hypertensive heart disease includes a number of complications of high blood pressure that affect the... more...

Related Diseases for Hypertensive Heart Disease

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 heart disease 30.1 ACE AGTR1 CD36 CTF1 NPPB NR3C2
2 nephrosclerosis 30.1 ACE AGTR1 NR3C2
3 atrial fibrillation 29.8 ACE AGT AGTR1 NPPB
4 renal dysplasia 29.7 ACE AGT AGTR1
5 diastolic heart failure 28.7 ACE AGT AGTR1 MMP2 NPPB
6 arteries, anomalies of 28.6 ACE AGT AGTR1 MMP9 NPPB
7 coronary artery anomaly 28.6 ACE AGT AGTR1 MMP9 NPPB
8 kidney disease 28.6 ACE AGT AGTR1 NPPB NR3C2
9 hypertension, essential 26.4 ACE AGT AGTR1 CYP11B2 NPPB NPR1
10 myocardial infarction 25.8 ACE AGT AGTR1 CTF1 MMP2 MMP9
11 dilated cardiomyopathy 25.6 ACE AGT AGTR1 CTF1 CYP11B2 MMP1
12 renal artery disease 10.7 ACE AGTR1
13 syndrome of inappropriate antidiuretic hormone 10.6 ACE NPPB
14 aortic valve insufficiency 10.6 ACE NPPB
15 pediatric hypertension 10.6 ACE AGT
16 hypertensive nephropathy 10.6 ACE AGTR1
17 ischemic heart disease 10.5 ACE NPPB
18 keloids 10.5 CD36 MMP1
19 familial hypertension 10.5 AGT AGTR1
20 renal hypertension 10.4 ACE AGTR1 NPPB
21 idiopathic edema 10.4 ACE NPPB NR3C2
22 systolic heart failure 10.4 ACE NPPB NR3C2
23 meningococcal infection 10.4 AGT AGTR1
24 conjunctivochalasis 10.4 MMP1 MMP2
25 hypertrophic scars 10.3 CD36 MMP2
26 mitral valve insufficiency 10.3 ACE NPPB
27 chronic actinic dermatitis 10.3 MMP1 MMP9
28 renal fibrosis 10.3 AGTR1 CD36 NR3C2
29 chromoblastomycosis 10.3 MMP1 MMP9
30 hypertrophic cardiomyopathy 10.3
31 aortic valve disease 2 10.3 ACE AGT NPPB
32 adult astrocytic tumour 10.2 MMP1 MMP9
33 posterior urethral valves 10.2 ACE AGT AGTR1
34 malignant hypertension 10.2 ACE AGT AGTR1
35 fibromuscular dysplasia 10.2 ACE AGT AGTR1
36 renal tubular dysgenesis 10.2 ACE AGT AGTR1
37 fibromatosis, gingival, 1 10.2 CD36 MMP1 MMP2
38 ischemic optic neuropathy 10.2 ACE AGT AGTR1
39 microvascular complications of diabetes 3 10.2 ACE AGT AGTR1
40 end stage renal failure 10.2 ACE AGT AGTR1
41 gingival fibromatosis 10.1 CD36 MMP1 MMP2
42 extracranial arteriovenous malformation 10.1 MMP2 MMP9
43 hypoaldosteronism 10.1 ACE CYP11B2
44 focal myositis 10.1 MMP2 MMP9
45 lentigo maligna melanoma 10.1 MMP2 MMP9
46 villous adenocarcinoma 10.1 MMP2 MMP9
47 psammomatous meningioma 10.1 MMP2 MMP9
48 acute transverse myelitis 10.1 MMP2 MMP9
49 nodular malignant melanoma 10.1 MMP1 MMP2
50 senile ectropion 10.1 MMP2 MMP9

Comorbidity relations with Hypertensive Heart Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to Hypertensive Heart Disease

Symptoms & Phenotypes for Hypertensive Heart Disease

MGI Mouse Phenotypes related to Hypertensive Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 MMP9 NPR1 NR3C2 MMP2 CD36 ACE
2 homeostasis/metabolism MP:0005376 10.11 MMP9 NPR1 NR3C2 CD36 ACE CTF1
3 growth/size/body region MP:0005378 10.09 MMP9 NR3C2 AGTR1 MMP2 CD36 ACE
4 hematopoietic system MP:0005397 10.01 MMP9 NPR1 NR3C2 AGTR1 MMP2 CD36
5 immune system MP:0005387 9.97 MMP9 NPR1 AGTR1 MMP2 CD36 ACE
6 adipose tissue MP:0005375 9.95 CD36 ACE CTF1 AGT CYP11B2 AGTR1
7 muscle MP:0005369 9.73 MMP9 NPR1 NR3C2 MMP2 CD36 AGT
8 nervous system MP:0003631 9.56 NR3C2 MMP9 AGTR1 MMP2 CD36 CTF1
9 neoplasm MP:0002006 9.55 MMP9 NPR1 MMP2 ACE MMP1
10 renal/urinary system MP:0005367 9.17 MMP9 NR3C2 CD36 ACE AGT CYP11B2

Drugs & Therapeutics for Hypertensive Heart Disease

Drugs for Hypertensive Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Irbesartan Approved, Investigational Phase 4,Phase 2,Phase 3 138402-11-6 3749
3
Ramipril Approved Phase 4 87333-19-5 5362129
4 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 2,Phase 3
5 Angiotensin Receptor Antagonists Phase 4,Phase 2,Phase 3
6 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 3
7 Angiotensinogen Phase 4,Phase 2,Phase 3
8 Antihypertensive Agents Phase 4,Phase 2,Phase 3
9 HIV Protease Inhibitors Phase 4
10
protease inhibitors Phase 4
11
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
12
Atenolol Approved Phase 2, Phase 3 29122-68-7 2249
13
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
14
Enalaprilat Approved Phase 3 76420-72-9 6917719
15 diuretics Phase 3,Not Applicable
16 Diuretics, Potassium Sparing Phase 3
17 Hormone Antagonists Phase 3
18 Hormones Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Mineralocorticoid Receptor Antagonists Phase 3
21 Mineralocorticoids Phase 3
22 Natriuretic Agents Phase 3
23 Adrenergic Agents Phase 2, Phase 3
24 Adrenergic Antagonists Phase 2, Phase 3
25 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
26 Adrenergic beta-Antagonists Phase 2, Phase 3
27 Anti-Arrhythmia Agents Phase 2, Phase 3
28 Autonomic Agents Phase 2, Phase 3
29 Neurotransmitter Agents Phase 2, Phase 3
30 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
31 Sympatholytics Phase 2, Phase 3
32 Pharmaceutical Solutions Phase 2
33
Resveratrol Approved, Experimental, Investigational Phase 1 501-36-0 445154
34 Grape Approved, Nutraceutical Phase 1
35 Antioxidants Phase 1,Not Applicable
36 Analgesics Phase 1
37 Analgesics, Non-Narcotic Phase 1
38 Anti-Inflammatory Agents Phase 1
39 Anti-Inflammatory Agents, Non-Steroidal Phase 1
40 Antineoplastic Agents, Phytogenic Phase 1
41 Antirheumatic Agents Phase 1
42 Grape Seed Extract Phase 1
43 Platelet Aggregation Inhibitors Phase 1
44 Protective Agents Phase 1
45 Anthocyanidin Nutraceutical Phase 1
46
Quercetin Experimental, Investigational, Nutraceutical Phase 1 117-39-5 5280343
47
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
48 tannic acid Approved, Nutraceutical Not Applicable
49
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
50
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan Unknown status NCT00517322 Phase 4 ramipril;irbesartan
2 Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease Completed NCT00865501 Phase 3 spironolactone;placebo
3 Irbesartan and Atenolol in Hypertensive Heart Disease Completed NCT00389168 Phase 2, Phase 3 Irbesartan;Atenolol
4 Studies of Left Ventricular Dysfunction (SOLVD) Completed NCT00000516 Phase 3 enalapril
5 Role of ARNi in Ventricular Remodeling in Hypertensive LVH Not yet recruiting NCT03553810 Phase 3 Entresto;Valsartan
6 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
7 Physiological Effects of Grape Seed Extract in Diastolic Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
8 Renal Sympathetic Denervation Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study Unknown status NCT01990911 Not Applicable Medical therapy
9 Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure Unknown status NCT00939640 Not Applicable
10 Clinical Research to Explore Manifestations of Heart Failure Using Infrared Thermal Imaging Technology Unknown status NCT02672618
11 Asian American Partnerships in Research and Empowerment (AsPIRE) Completed NCT03100812 Not Applicable
12 Vitamin D Therapy to Reduce Cardiac Damage Among Vulnerable Hypertensive Patients Completed NCT01360476 Not Applicable
13 Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR Completed NCT00811668 Not Applicable
14 Differentiating Hypertrophic Cardiomyopathy From Hypertensive Heart Disease Recruiting NCT03271385
15 Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease Recruiting NCT03476785 Not Applicable
16 REMODEL: Hypertensive Heart Disease Recruiting NCT02670031
17 E_Stethoscope: Portable Digital Auscultation Study on Hypertensive/Hypertensive Heart Disease Patients Active, not recruiting NCT02809040
18 Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2) Terminated NCT01942395 Not Applicable

Search NIH Clinical Center for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

Anatomical Context for Hypertensive Heart Disease

MalaCards organs/tissues related to Hypertensive Heart Disease:

41
Heart, Bone, Endothelial, Monocytes, Tongue, Kidney, Bone Marrow

Publications for Hypertensive Heart Disease

Articles related to Hypertensive Heart Disease:

(show top 50) (show all 390)
# Title Authors Year
1
An essential role for Wnt/I^-catenin signaling in mediating hypertensive heart disease. ( 29895976 )
2018
2
Three-dimensional echocardiography: a further step in the evaluation of hypertensive heart disease. ( 29952849 )
2018
3
Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease. ( 29449707 )
2018
4
Oxygenation-sensitive cardiovascular magnetic resonance in hypertensive heart disease with left ventricular myocardial hypertrophy and non-left ventricular myocardial hypertrophy: Insight from altered mechanics and cardiac BOLD imaging. ( 29734491 )
2018
5
Hypertensive heart disease beyond left ventricular hypertrophy: are we ready for echocardiographic strain evaluation in everyday clinical practice? ( 29227376 )
2017
6
Cardiac magnetic resonance imaging provides new insight into hypertensive heart disease-a reply. ( 28139052 )
2017
7
Fragmented QRS: A marker of hypertensive heart disease? ( 28721702 )
2017
8
Histamine-2 receptor antagonist famotidine modulates cardiac stem cell characteristics in hypertensive heart disease. ( 29038754 )
2017
9
Regression of Established Cardiac Fibrosis in Hypertensive Heart Disease. ( 28379281 )
2017
10
Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging. ( 28373647 )
2017
11
A predominance of hypertensive heart disease among patients with cardiac disease in Buea, a semi-urban setting, South West Region of Cameroon. ( 29202813 )
2017
12
The emerging role of Cardiovascular Magnetic Resonance in the evaluation of hypertensive heart disease. ( 28535761 )
2017
13
Heart Failure WithA Preserved EjectionA Fraction: A Late Stage of Hypertensive Heart Disease. ( 29096816 )
2017
14
Relaxation and the Role of Calcium in Isolated Contracting Myocardium From Patients With Hypertensive Heart Disease and Heart Failure With Preserved Ejection Fraction. ( 28784688 )
2017
15
Hypertrophic cardiomyopathy and left ventricular hypertrophy in hypertensive heart disease with mildly reduced or preserved ejection fraction: insight from altered mechanics and native T1 mapping. ( 28552325 )
2017
16
MiR-19b and miR-16 cooperatively signaling target the regulator ADRA1A in Hypertensive heart disease. ( 28531963 )
2017
17
Comparison of Pulmonary Venous and Left Atrial Remodeling in Patients With Atrial Fibrillation With Hypertrophic Cardiomyopathy Versus With Hypertensive Heart Disease. ( 28214001 )
2017
18
Carotid artery intima-media thickness and hypertensive heart disease: a short review. ( 28373912 )
2017
19
Reply: Heart Failure With Preserved EjectionA Fraction: A Late Stage of Hypertensive Heart Disease. ( 29096817 )
2017
20
High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats. ( 28888352 )
2017
21
Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway. ( 28971696 )
2017
22
NT-pro BNP and plasma-soluble ST2 as promising biomarkers for hypertension, hypertensive heart disease and heart failure in sub-Saharan Africa. ( 29297544 )
2017
23
A Novel Index of Remodeling in Hypertensive Heart Disease. ( 28847912 )
2017
24
Cardiac magnetic resonance imaging provides a new insight in hypertensive heart disease. ( 28139099 )
2017
25
Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. ( 28630342 )
2017
26
Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry. ( 26766206 )
2016
27
JS ISH-ESH-2 UPDATE ON THE DETECTION AND FOLLOW-UP OF EARLY HYPERTENSIVE HEART DISEASE. ( 27642917 )
2016
28
The interplay between renin-angiotensin system activation, abnormal myocardial deformation and neurohumoral activation in hypertensive heart disease: a speckle tracking echocardiography study. ( 27787699 )
2016
29
Electrocardiography for Assessment of Hypertensive Heart Disease: A New Role for an Old Tool. ( 27160048 )
2016
30
Recurrent Syncope: An Unusual Complication of Hypertensive Heart Disease. ( 27448490 )
2016
31
SY 05-2 PROGRESSION OF HYPERTENSIVE HEART DISEASE: NEW THERAPEUTIC APPROACH. ( 27753836 )
2016
32
The septal bulge-an early echocardiographic sign in hypertensive heart disease. ( 26850524 )
2016
33
Factors associated to hypertensive heart disease development: a prospective cohort study in Bayamo, Cuba. ( 27571318 )
2016
34
Cardiac Fibrosis in Aortic Stenosis and Hypertensive Heart Disease Assessed by Magnetic Resonance T1 Mapping. ( 28238233 )
2016
35
The Relationship Between Left Ventricular Wall Thickness, Myocardial Shortening, and Ejection Fraction in Hypertensive Heart Disease: Insights From Cardiac Magnetic Resonance Imaging. ( 27316563 )
2016
36
Effect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease. ( 26916982 )
2016
37
Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy. ( 27142065 )
2016
38
Case 2/2016 - 76-Year-Old Male with Hypertensive Heart Disease, Renal Tumor and Shock. ( 27305288 )
2016
39
SY 05-2 PROGRESSION OF HYPERTENSIVE HEART DISEASE: NEW THERAPEUTIC APPROACH. ( 27642889 )
2016
40
JS ISH-ESH-2 UPDATE ON THE DETECTION AND FOLLOW-UP OF EARLY HYPERTENSIVE HEART DISEASE. ( 27754006 )
2016
41
Comprehensive characterisation of hypertensive heart disease left ventricular phenotypes. ( 27260191 )
2016
42
Hypertensive heart disease versus hypertrophic cardiomyopathy: multi-parametric cardiovascular magnetic resonance discriminators when end-diastolic wall thickness a8Y 15 mm. ( 27368925 )
2016
43
Aircraft, road and railway traffic noise as risk factors for heart failure and hypertensive heart disease-A case-control study based on secondary data. ( 27667192 )
2016
44
Fragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease. ( 27774963 )
2016
45
Prognostic Implications of LV Strain RiskA ScoreA inA Asymptomatic Patients WithA Hypertensive Heart Disease. ( 27344417 )
2016
46
Screening and Treatment for Subclinical Hypertensive Heart Disease in Emergency Department Patients With Uncontrolled Blood Pressure: A Cost Effectiveness Analysis. ( 27797437 )
2016
47
Obesity and hypertensive heart disease: focus on body composition and sex differences. ( 27956942 )
2016
48
Myocardial dysfunction in patients with aortic stenosis and hypertensive heart disease assessed by MR tissue phase mapping. ( 26687082 )
2015
49
CMR imaging of extracellular volume and myocardial strain in hypertensive heart disease. ( 25677890 )
2015
50
Prevalence and predictors of asymmetric hypertensive heart disease: insights from cardiac and aortic function with cardiovascular magnetic resonance. ( 26705488 )
2015

Variations for Hypertensive Heart Disease

Expression for Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for Hypertensive Heart Disease

Pathways related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.59 AGTR1 MMP1 MMP2 MMP9
2 11.93 MMP1 MMP2 MMP9
3
Show member pathways
11.9 AGT CTF1 NPPB
4 11.68 CD36 MMP1 MMP2 MMP9
5
Show member pathways
11.65 MMP1 MMP2 MMP9
6 11.5 MMP1 MMP2 MMP9
7
Show member pathways
11.41 MMP1 MMP2 MMP9
8 11.37 MMP1 MMP2 MMP9
9 11.27 ACE AGT AGTR1 NPR1
10 11.08 MMP1 MMP2 MMP9
11 10.97 MMP2 MMP9
12 10.95 AGT CTF1
13
Show member pathways
10.92 ACE AGT AGTR1 CYP11B2 NR3C2
14 10.83 MMP1 MMP2
15 10.79 ACE MMP2 MMP9
16 10.76 ACE CD36 MMP2 MMP9
17 10.73 MMP1 MMP9

GO Terms for Hypertensive Heart Disease

Cellular components related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ACE AGT CTF1 MMP1 MMP2 MMP9
2 receptor complex GO:0043235 9.33 CD36 NPR1 NR3C2
3 extracellular space GO:0005615 9.17 ACE AGT CD36 CTF1 MMP2 MMP9

Biological processes related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.85 CD36 CTF1 MMP1 MMP2 MMP9
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 AGT AGTR1 CD36
3 negative regulation of cell growth GO:0030308 9.81 AGT NPPB NPR1
4 negative regulation of angiogenesis GO:0016525 9.8 AGT NPPB NPR1
5 cell surface receptor signaling pathway GO:0007166 9.8 AGT CD36 CTF1 NPPB NPR1
6 kidney development GO:0001822 9.79 ACE AGT AGTR1
7 extracellular matrix disassembly GO:0022617 9.75 MMP1 MMP2 MMP9
8 collagen catabolic process GO:0030574 9.73 MMP1 MMP2 MMP9
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.69 AGT MMP2 MMP9
10 positive regulation of protein tyrosine kinase activity GO:0061098 9.67 ACE AGT
11 blood vessel remodeling GO:0001974 9.67 ACE AGT
12 endodermal cell differentiation GO:0035987 9.66 MMP2 MMP9
13 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.66 AGT MMP9
14 cGMP biosynthetic process GO:0006182 9.65 NPPB NPR1
15 nitric oxide mediated signal transduction GO:0007263 9.65 AGT CD36
16 positive regulation of reactive oxygen species metabolic process GO:2000379 9.65 AGT AGTR1 CD36
17 positive regulation of cellular protein metabolic process GO:0032270 9.64 AGT AGTR1
18 positive regulation of urine volume GO:0035810 9.63 NPPB NPR1
19 low-density lipoprotein particle remodeling GO:0034374 9.62 AGT AGTR1
20 angiotensin maturation GO:0002003 9.61 ACE AGT
21 regulation of vascular permeability GO:0043114 9.61 NPPB NPR1
22 regulation of vasoconstriction GO:0019229 9.61 ACE AGT AGTR1
23 receptor guanylyl cyclase signaling pathway GO:0007168 9.6 NPPB NPR1
24 positive regulation of cholesterol esterification GO:0010873 9.59 AGT AGTR1
25 body fluid secretion GO:0007589 9.58 NPPB NPR1
26 positive regulation of NAD(P)H oxidase activity GO:0033864 9.57 AGT AGTR1
27 regulation of renal sodium excretion GO:0035813 9.55 AGT AGTR1
28 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGT AGTR1
29 regulation of blood vessel size GO:0050880 9.54 AGT NPPB NPR1
30 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.52 AGT AGTR1
31 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.5 AGT AGTR1 CD36
32 regulation of renal output by angiotensin GO:0002019 9.49 ACE AGT
33 regulation of blood pressure GO:0008217 9.46 ACE AGT NPPB NPR1
34 positive regulation of renal sodium excretion GO:0035815 9.43 AGT NPPB NPR1
35 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
36 regulation of blood vessel diameter GO:0097746 8.92 ACE AGTR1 NPPB NPR1

Molecular functions related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.72 ACE MMP1 MMP2 MMP9 NR3C2
2 peptidase activity GO:0008233 9.67 ACE MMP1 MMP2 MMP9
3 metalloendopeptidase activity GO:0004222 9.43 MMP1 MMP2 MMP9
4 endopeptidase activity GO:0004175 9.33 ACE MMP1 MMP9
5 metallopeptidase activity GO:0008237 9.26 ACE MMP1 MMP2 MMP9
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Hypertensive Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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