Hypertensive Heart Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP006 MIFTS: 49	Hypertensive Heart Disease Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Hypertensive Heart Disease

MalaCards integrated aliases for Hypertensive Heart Disease:

Name: Hypertensive Heart Disease ¹² ⁵⁴ ¹⁵ ⁷¹ ³²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the circulatory system

Hypertensive diseases

Hypertensive heart disease

Hypertensive heart disease with (congestive) heart failure

Hypertensive heart disease without (congestive) heart failure

External Ids:

Disease Ontology ¹² DOID:11516

ICD9CM ³⁴ 402

NCIt ⁵⁰ C157879

SNOMED-CT ⁶⁷ 155297007

ICD10 ³² I11 I11.0 I11.9

UMLS ⁷¹ C0152105

Sources

Summaries for Hypertensive Heart Disease

Disease Ontology : ¹² A heart disease that is caused by high blood pressure.

MalaCards based summary : Hypertensive Heart Disease is related to cardiovascular system disease and muscle hypertrophy. An important gene associated with Hypertensive Heart Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cytokine Signaling in Immune system and p70S6K Signaling. The drugs Spironolactone and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁴ Hypertensive heart disease includes a number of complications of high blood pressure that affect the... more...

Sources

Related Diseases for Hypertensive Heart Disease

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)

#	Related Disease	Score	Top Affiliating Genes
1	cardiovascular system disease	30.8	NR3C2 NPPB NPPA IGF1 CYP11B2 AGTR1
2	muscle hypertrophy	30.4	MSTN IGF1 FGF2
3	hypertensive retinopathy	30.2	NR3C2 AGTR1 ACE
4	renal dysplasia	30.2	AGTR1 AGT ACE
5	nephrosclerosis	30.2	NR3C2 CASP3 AGTR1 ACE
6	mitral valve insufficiency	30.2	NR3C2 NPPB NPPA ACE
7	sleep apnea	30.2	NPPB IGF1 AGT ACE
8	renovascular hypertension	30.2	NPPB NPPA AGTR1 ACE
9	mitral valve stenosis	30.2	NPPB NPPA ACE
10	aortic dissection	30.1	MMP9 MMP2 ACE
11	ischemia	30.0	NPPB FGF2 CASP3 ACE
12	renal hypertension	30.0	NR3C2 NPPB AGTR1 AGT ACE
13	first-degree atrioventricular block	29.9	NPPB ACE
14	arteriosclerosis	29.9	MMP9 FGF2 ANXA5 ACE
15	aortic valve insufficiency	29.9	NPPB NPPA ACE
16	pericardial effusion	29.9	NPPB NPPA FGF2 ACE
17	atrial fibrillation	29.9	NR3C2 NPPB NPPA AGTR1 AGT ACE
18	familial hypertension	29.9	NR3C2 NPPA CYP11B2 AGTR1 AGT
19	pulmonary edema	29.8	NPPB NPPA AGTR1 ACE
20	vascular disease	29.8	NPPB MMP9 IGF1 FGF2 CASP3 AGT
21	congestive heart failure	29.8	NR3C2 NPR1 NPPB NPPA CYP11B2 AGTR1
22	diastolic heart failure	29.8	NPPB NPPA MMP9 MMP2 MMP1 AGTR1
23	heart valve disease	29.8	NR3C2 NPPB NPPA CTF1 ACE
24	kidney disease	29.7	NR3C2 NPPB NPPA AGTR1 AGT ACE
25	malignant hypertension	29.7	NPPB NPPA AGTR1 AGT ACE
26	lipoprotein quantitative trait locus	29.4	NPPB NPPA MMP9 FGF2 CASP3 AGTR1
27	systolic heart failure	29.4	NR3C2 NPPB NPPA MMP9 MMP2 CYP11B2
28	polycystic kidney disease	29.3	MMP9 IGF1 FGF2 CASP3 AGTR1 AGT
29	hypertrophic cardiomyopathy	29.2	TPM1 NR3C2 NPPB NPPA MMP9 MMP2
30	stroke, ischemic	29.1	NPPB NPPA MMP9 CASP3 ANXA5 AGTR1
31	body mass index quantitative trait locus 11	28.9	NR3C2 NPR1 MSTN IGF1 AGT ACE
32	pulmonary hypertension	28.9	NPPB NPPA MMP9 IGF1 FGF2 CASP3
33	chronic kidney disease	28.9	NR3C2 NPPB NPPA MMP9 MMP2 IGF1
34	autosomal dominant polycystic kidney disease	28.8	NPPA MSTN IGF1 CYP11B2 CASP3 AGTR1
35	dilated cardiomyopathy	28.5	TPM1 TIMP2 NR3C2 NPPB NPPA MMP9
36	hypertension, essential	28.4	NR3C2 NPR1 NPPB NPPA MMP9 MMP2
37	heart disease	28.3	TPM1 TIMP2 NR3C2 NPPB NPPA MSTN
38	atrial standstill 1	10.6
39	extracranial arteriovenous malformation	10.4	MMP9 MMP2
40	focal myositis	10.4	MMP9 MMP2
41	aldosterone-producing adenoma	10.4	CYP11B2 AGTR1
42	fibrosis of extraocular muscles, congenital, 1	10.4
43	acute transverse myelitis	10.4	MMP9 MMP2
44	lentigo maligna melanoma	10.4	MMP9 MMP2
45	lateral myocardial infarction	10.4	NR3C2 ACE
46	nasal cavity squamous cell carcinoma	10.4	MMP9 MMP2
47	toxic myocarditis	10.4	NPPB ACE
48	chronic actinic dermatitis	10.4	MMP9 MMP1
49	fungal keratitis	10.4	TIMP2 MMP9
50	senile ectropion	10.4	MMP9 MMP2

Comorbidity relations with Hypertensive Heart Disease via Phenotypic Disease Network (PDN):

Acute Cystitis	Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:

Sources

Symptoms & Phenotypes for Hypertensive Heart Disease

GenomeRNAi Phenotypes related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	9.6	TPM1
2	Decreased viability	GR00055-A-2	9.6	TPM1
3	Decreased viability	GR00055-A-3	9.6	TPM1
4	Decreased viability	GR00240-S-1	9.6	CD36
5	Decreased viability	GR00249-S	9.6	AGT CD36 FGF2 NPPA TPM1
6	Decreased viability	GR00386-A-1	9.6	AGT CD36 FGF2 NPR1 NR3C2 TPM1
7	Decreased viability	GR00402-S-2	9.6	CYP11B2 NPPA NPR1 TPM1

MGI Mouse Phenotypes related to Hypertensive Heart Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.33	ACE AGT AGTR1 CASP3 CD36 CYP11B2
2	homeostasis/metabolism	MP:0005376	10.3	ACE AGT AGTR1 CASP3 CD36 CTF1
3	growth/size/body region	MP:0005378	10.28	ACE AGT AGTR1 CASP3 CD36 CTF1
4	hematopoietic system	MP:0005397	10.25	ACE AGTR1 ANXA5 CASP3 CD36 CYP11B2
5	immune system	MP:0005387	10.17	ACE AGT AGTR1 ANXA5 CASP3 CD36
6	adipose tissue	MP:0005375	10.08	ACE AGT AGTR1 CD36 CTF1 CYP11B2
7	muscle	MP:0005369	10	AGT CASP3 CD36 FGF2 IGF1 MMP2
8	nervous system	MP:0003631	9.77	ACE AGT AGTR1 CASP3 CD36 CTF1
9	neoplasm	MP:0002006	9.7	ACE FGF2 IGF1 MMP1 MMP2 MMP9
10	renal/urinary system	MP:0005367	9.36	ACE AGT AGTR1 CASP3 CD36 CYP11B2

Sources

Drugs & Therapeutics for Hypertensive Heart Disease

Drugs for Hypertensive Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Spironolactone

Approved

Phase 3

1952-01-7, 52-01-7

5833

Synonyms:

4-18-00-01601 (Beilstein Handbook Reference)

496916-40-6

4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate

52-01-7

7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone

7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone

AB00513806

Abbolactone

AC1L1L8Q

AC-4214

Acelat

Aldace

Aldactazide

Aldactide

Aldactone

Aldactone (TN)

Aldactone a

Aldactone A

Alderon

Aldopur

Almatol

Alphapharm brand OF spironolactone

Alphapharm Brand of Spironolactone

Alpharma brand OF spironolactone

Alpharma Brand of Spironolactone

Alter brand OF spironolactone

Alter Brand of Spironolactone

Altex

Aquareduct

Ashbourne brand OF spironolactone

Ashbourne Brand of Spironolactone

Azupharma brand OF spironolactone

Azupharma Brand of Spironolactone

betapharm Brand of Spironolactone

Betapharm brand OF spironolactone

BIDD:PXR0071

BPBio1_000194

BRD-K90027355-001-03-4

BRN 0057767

BSPBio_000176

C07310

C24H32O4S

Cardel brand OF spironolactone

Cardel Brand of Spironolactone

CHEBI:428201

CHEBI:45692

CHEBI:9241

CHEMBL1393

CID5833

CPD000471892

ct Arzneimittel Brand of Spironolactone

CT Arzneimittel brand OF spironolactone

CT, Spiro von

ct-Arzneimittel Brand of Spironolactone

CT-Arzneimittel brand OF spironolactone

D00443

D013148

DB00421

Deverol

Dexo brand OF spironolactone

Dexo Brand of Spironolactone

Diatensec

Dira

Duraspiron

EINECS 200-133-6

Espironolactona

Espironolactona [INN-Spanish]

Espironolactona alter

Espironolactona Alter

Espironolactona mundogen

Espironolactona Mundogen

Euteberol

Flumach

Frumikal

Generosan brand OF spironolactone

Generosan Brand of Spironolactone

HMS1568I18

HMS2090N21

Hormosan brand OF spironolactone

Hormosan Brand of Spironolactone

HSDB 3184

I06-1970

Jenapharm brand OF spironolactone

Jenapharm Brand of Spironolactone

Jenaspiron

Lacalmin

Lacdene

Laractone

LS-118614

LT00772287

Mayoly-spindler brand OF spironolactone

Mayoly-Spindler Brand of Spironolactone

Melarcon

Merck dura brand OF spironolactone

Merck dura Brand of Spironolactone

MLS001074672

MLS001333253

MLS001333254

MLS002153245

MLS002207058

Mundogen brand OF spironolactone

Mundogen Brand of Spironolactone

NCGC00164397-01

NCGC00164397-02

Nefurofan

Novo spiroton

Novo Spiroton

Novopharm brand OF spironolactone

Novopharm Brand of Spironolactone

Novo-spiroton

NovoSpiroton

Novo-Spiroton

NSC 150399

NSC150399

Osyrol

Pfizer brand OF spironolactone

Pfizer Brand of Spironolactone

Pharmafrid brand OF spironolactone

Pharmafrid Brand of Spironolactone

Practon

Prestwick0_000128

Prestwick1_000128

Prestwick2_000128

Prestwick3_000128

Roche brand OF spironolactone

Roche Brand of Spironolactone

S0260

S3378_SIGMA

Sagisal

SAM002264648

SC 9420

SC9420

SC-9420

Searle brand OF spironolactone

Searle Brand of Spironolactone

Sincomen

SMR000471892

SNL

SPBio_002115

Spiractin

Spiresis

Spiretic

Spiridon

Spiro l.u.t.

Spiro L.U.T.

spiro von ct

Spiro von CT

Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)

Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]

Spirobeta

Spiroctan

Spiroctanie

Spiroderm

Spirogamma

Spirolactone

Spirolakton

Spirolang

Spirolone

Spirone

Spirono isis

Spirono Isis

Spironocompren

Spirono-isis

Spirono-Isis

spironolactone

Spironolactone

Spironolactone (JP15/USP/INN)

Spironolactone [BAN:INN:JAN]

Spironolactone [INN:BAN:JAN]

Spironolactone A

Spironolactonum

Spironolactonum [INN-Latin]

spironolattone

Spironolattone

Spironolattone [DCIT]

Spironone

Spirospare

Spiro-Tablinen

Sprioderm

Supra-puren

Suracton

UNII-27O7W4T232

Uractone

Urusonin

Veroshpiron

Verospiron

Verospirone

Verospirone Opianin

von ct, spiro

Von CT, spiro

WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ

Worwag Brand of Spironolactone

Wörwag brand OF spironolactone

Xenalon

ZINC03861599

Amlodipine

Approved

Phase 3

88150-42-9

2162

Synonyms:

()-Amlodipine

(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)

-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester

3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester

3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl ( -)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat

3-Ethyl-5-methyl ( -)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (.+/-.)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid

3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

88150-42-9

88150-47-4 (maleate (1:1))

AC1L1D26

AC1Q32ZS

AC-4535

Almirall brand OF amlodipine besilate

Ambap88150-42-9

Amlocard

amlodipine

Amlodipine

Amlodipine (INN)

Amlodipine [INN:BAN]

AMLODIPINE BASE

Amlodipine Benzenesulfonate

Amlodipine besilate

Amlodipine Besilate

Amlodipine besylate

Amlodipine Besylate

Amlodipine free base

Amlodipine Free Base

Amlodipine maleate

Amlodipine maleate (1:1)

Amlodipine, (+-)-isomer

Amlodipine, (+-)-isomer, maleate (1:1)

Amlodipine, (R)-isomer

Amlodipine, (S)-isomer, maleate (1:1)

Amlodipino

Amlodipino [Spanish]

Amlodipinum

Amlodipinum [Latin]

Amlodis

Amlopres

Amlor

Amvaz

AMVAZ

Astudal

BIDD:GT0810

BRD-A22032524-074-02-4

BRD-A22032524-074-03-2

BSPBio_002727

C06825

CHEBI:2668

CHEMBL1491

CID2162

Coroval

CPD000469198

D07450

DB00381

Eczacibasi brand OF amlodipine besilate

HMS2052N03

HMS2089H07

I14-0798

Intervask

Istin

KBio3_001947

KBioGR_001643

Lipinox

Lotrel

LS-131183

Mack brand OF amlodipine besilate

MLS001401409

MolPort-001-792-963

NCGC00165957-01

NCGC00165957-02

NCGC00165957-03

Norvasc

Norvasc (TN)

Pelmec

Pfizer brand OF amlodipine besilate

R,S)-Amlodipine

Racemic amlodipine

Racemic Amlodipine

SAM001246705

SMR000469198

SPBio_000351

Spectrum2_000486

Spectrum3_001004

Spectrum4_001132

Spectrum5_001550

UK-4834011

UNII-1J444QC288

Angiotensin II

Approved, Investigational

Phase 3

68521-88-0, 4474-91-3, 11128-99-7

172198

Synonyms:

1-8-Angiotensin I

1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide

5 L Isoleucine angiotensin II

5-isoleucine-angiotensin II

5-Isoleucine-angiotensin II

5-L-Isoleucine angiotensin II

5-L-isoleucineangiotensin II

5-L-Isoleucineangiotensin II

Ang II

ANG-(1-8)octapeptide

Angiotensin

Angiotensin 2

Angiotensin II

Angiotensin II (human)

Angiotensin II (mouse)

Angiotensin II, 5-L-isoleucine

Angiotensin-(1-8) octapeptide

Angiotonin

Asp-arg-val-tyr-ile-his-pro-phe

Delivert

Human angiotensin II

Hypertensin

II, 5-L-isoleucine angiotensin

Ile(5)-angiotensin II

Ile5-angiotensin II

Isoleucine(5)-angiotensin

Isoleucine(5)-angiotensin II

isoleucine5-angiotensin II

Isoleucyl(5)-angiotensin II

N-(1-(N-(N-(N-(N-(N(2)-L-a-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

N-(1-(N-(N-(N-(N-(N(2)-L-alpha-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

N-(1-(N-(N-(N-(N-(N(2)-L-Α-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine

Valyl(5)-angiotensin II

Valsartan

Approved, Investigational

Phase 3

137862-53-4

60846

Synonyms:

(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid

(s)-2-(n-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid

(S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine

(S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine

|Tareg

137862-53-4

AC1L1U1M

AC1Q5QIK

AC-4543

Ambap137862-53-4

Aventis brand of valsartan

BIDD:GT0345

Bio-0796

BRD-K45158365-001-02-3

BSPBio_003501

C081489

C24H29N5O3

CEPA brand of valsartan

CGP 48933

CGP-48933

CHEBI:9927

CHEMBL1069

CID60846

CPD000466318

D00400

DB00177

Diovan

Diovan (TN)

Diovan, Valsartan

Esteve brand of valsartan

HMS1922L21

HMS2051L12

HMS2093K22

HSDB 7519

Kalpress

KBio2_002287

KBio2_004855

KBio2_007423

KBio3_003006

KBioGR_001078

KBioSS_002289

Lacer brand of valsartan

LS-161334

L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)

Miten

MLS000759423

MLS001424088

MolPort-002-507-854

MolPort-003-666-608

N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine

N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine

N-(p-(O-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine

N-(P-(O-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine

Nisis

Nisis||

Novartis brand of valsartan

N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine

N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine

N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine

N-valeryl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)valine

N-Valeryl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)valine

Provas

S1894_Selleck

SAM001246581

Sanol brand of valsartan

Schwarz brand of valsartan

SMR000466318

SPBio_001260

Spectrum_001796

SPECTRUM1505209

Spectrum2_001120

Spectrum3_001831

Spectrum4_000749

Spectrum5_001582

Tareg

TL8000869

UNII-80M03YXJ7I

Vals

Valsarran

valsartan

Valsartan

Valsartan (JAN/USAN/INN)

Valsartan [USAN:INN]

walsartan

Hydrochlorothiazide

Approved, Vet_approved

Phase 3

58-93-5

3639

Synonyms:

125727-50-6

3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi

3,4-Dihydrochlorothiazide

58-93-5

6-Chloro-7-sulfamoyl-3, 4-dihy

8049-49-8

AB00052012

AC-11072

AC1L1GDT

AC1Q55FM

Acesistem

Acuilix

Acuretic

adiazine-1,1-dioxide

AF-614/30832002

AKOS000121373

Aldactazide

Aldactazide 25/25

Aldazida

Aldectazide 50/50

Aldoril

Ambap58-93-5

Apo-Hydro

Apresazide

Aquarills

Aquarius

Aquazide H

Aquazide-H

ARONIS24316

BAS 00371709

BIDD:GT0153

Bio-0714

BPBio1_000019

BRD-K13078532-001-05-2

Bremil

Briazide

BRN 0625101

BSPBio_000017

BSPBio_002132

C7H8ClN3O4S2

Caplaril

Capozide

Carozide

CAS-58-93-5

Catiazida

CCRIS 2082

CHEMBL435

Chlorizide

Chlorosulthiadil

Chlorothiazide

Chlorsulfonamidodihydrobenzothiadiazine dioxide

Chlorzide

Chlothia

CID3639

Cidrex

Clorana

component of Aldactazide

component of Aldoril

Component of Butizide Prestabs

component of Caplaril

component of Cyclex

component of Dyazide

component of Esimil

Concor Plus

Condiuren

CPD000035778

D00340

D006852

DB00999

Diaqua

Dichlorosal

Dichlorotride

Dichlothiazide

Dichlotiazid

Dichlotride

diclot ride

Diclotride

Dicyclotride

Didral

Dihydran

Dihydrochlorothiazid

Dihydrochlorothiazide

Dihydrochlorothiazidum

Dihydrochlorurit

Dihydrochlorurite

Dihydroxychlorothiazidum

Direma

Disalunil

Disothiazid

Diu 25 Vigt

Diu-melusin

Diu-Melusin

Diuril

Diurogen

DivK1c_000289

Dixidrasi

Drenol

dro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Dyazide

EINECS 200-403-3

Esidrex

Esidrix

Esidrix (TN)

Esimil

Esoidrina

EU-0100614

Fluvin

FT-0082750

H 4759

H1274

H2910_SIAL

H4759_SIAL

HCT

HCT-Isis

HCTZ

HCZ

Hidril

Hidrochlortiazid

Hidroclorotiazida

Hidroclorotiazida [INN-Spanish]

Hidro-Niagrin

Hidroronol

Hidrosaluretil

Hidrotiazida

HMS1568A19

HMS1920D19

HMS2091L05

HMS500O11

HMS553N04

HSDB 3096

Hyclosid

Hydrex-semi

Hydril

Hydro Par

Hydro-aquil

Hydro-Aquil

Hydro-chlor

Hydrochlorat

Hydrochloro thiazide

Hydrochlorot

Hydrochlorothiazid

hydrochlorothiazide

Hydrochlorothiazide

Hydrochlorothiazide (JP15/USP/INN)

Hydrochlorothiazide [INN:BAN:JAN]

Hydrochlorothiazide intensol

Hydrochlorothiazide Intensol

Hydrochlorothiazidum

Hydrochlorothiazidum [INN-Latin]

Hydrochlorthiazide

Hydrochlorthiazidum

Hydrocot

Hydro-D

Hydrodiuretic

Hydrodiuril

Hydro-diuril

Hydro-Diuril

HydroDIURIL

Hydropres

Hydrosaluric

Hydro-Saluric

Hydro-T

Hydrothide

Hydrozide

Hydrozide Injection, Veterinary

Hypothiazid

Hypothiazide

Hytrid

Hyzaar

I09-0531

IDI1_000289

Idroclorotiazide

Idroclorotiazide [DCIT]

Idrotiazide

Inderide

Inderide 80/25

Indroclor

Ivaugan

Jen-diril

Jen-Diril

KBio1_000289

KBio2_001357

KBio2_003925

KBio2_006493

KBio3_001352

KBioGR_000351

KBioSS_001357

Lopac0_000614

Lopac-H-4759

Lopressor HCT

Lotensin Hct

Lotensin HCT

LS-243

Manuril

Maschitt

Maxzide

Maybridge Compound 10

Maybridge1_004336

Mazide 25 mg

Medozide

Megadiuril

Microzide

Microzide (TN)

Mictrin

Mikorten

MLS000069619

Modurcen

Moduretic

MolPort-000-144-465

Natrinax

NCGC00015508-01

NCGC00015508-02

NCGC00015508-03

NCGC00015508-07

NCGC00015508-12

NCGC00021906-03

NCGC00021906-04

NCGC00021906-05

NCGC00021906-06

NCGC00021906-07

NCGC00021906-08

NCI60_004317

NCI-C55925

Nefrix

Nefrol

Neo-codema

Neo-Codema

Neoflumen

Neo-Flumen

Neo-Minzil

Newtolide

NINDS_000289

Novodiurex

NSC 53477

NSC53477

Oprea1_357174

Oretic

Pantemon

Panurin

panurin dichloride

Prestwick_263

Prestwick0_000009

Prestwick1_000009

Prestwick2_000009

Prestwick3_000009

Prinzide

Raunova Plus

Ro-hydrazide

Ro-Hydrazide

Roxane

S1708_Selleck

Saldiuril

SAM002554901

Sectrazide

Selozide

Ser-ap-es

Servithiazid

SMR000035778

SPBio_001259

SPBio_001938

Spectrum_000877

SPECTRUM1500335

Spectrum2_001040

Spectrum3_000456

Spectrum4_000006

Spectrum5_000824

Spironazide

STK315354

Su 5879

Tandiur

Thiaretic

Thiuretic

Thlaretic

Timolide

Unazid

UNII-0J48LPH2TH

Unipres

Urodiazin

Urozide

Vaseretic

Vetidrex

WLN: T66 BSWM EM DHJ HG ISZW

Ziac

Zide

ZINC00896569

diuretics

Phase 3

Hormone Antagonists

Phase 3

Hormones

Phase 3

Mineralocorticoid Receptor Antagonists

Phase 3

Diuretics, Potassium Sparing

Phase 3

Mineralocorticoids

Phase 3

Angiotensin Receptor Antagonists

Phase 3

Angiotensinogen

Phase 3

Antihypertensive Agents

Phase 3

Angiotensin II Type 1 Receptor Blockers

Phase 3

LCZ 696

Phase 3

Giapreza

Phase 3

Atropine

Approved, Vet_approved

5908-99-6, 51-55-8

174174

Synonyms:

(+-)-atropine

(+-)-Atropine

(+-)-hyoscyamine

(+-)-Hyoscyamine

(+,-)-Tropyl tropate

(+,-)-Tropyl tropic acid

(+/-)-Atropine

(+/-)-Hyoscyamine

(±)-atropine

(±)-hyoscyamine

(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate

(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate

(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate

(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate

(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropic acid

(3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol

(3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane

(3-exo)-8-methyl-8-azabicyclo[3.2.1]octan-3-ol

[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate

[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate

[(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate

[(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoic acid

120-29-6

1alphaH,5alphaH-Tropan-3alpha-ol

1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester)

1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester)

1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI)

1alphaH,5alphaH-Tropan-3beta-ol

2-Phenylhydracrylic acid 3-alpha-tropanyl ester

51-55-8

8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate

8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoic acid

8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate

8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropic acid

8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate

A0132_SIGMA

A2468_SIGMA

AC1L5AX3

AC1Q3XL2

ACon1_000046

AI3-60219

AKOS005137976

Ambap120-29-6

Anaspaz

Atropair

Atropen

Atropen (TN)

Atropin

Atropin [German]

Atropina

Atropina [Italian]

a-Tropine

Atropine

ATROPINE

Atropine (USP)

Atropine [BAN]

Atropine Care

Atropine sulfate

Atropine Sulfate S.O.P.

Atropin-flexiolen

atropinium cation

atropinium(1+)

Atropinol

Atropinum

Atropt

Atrosulf

b eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Belladenal

Bellergal-S

Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester

beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]

beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]

bmse000649

BRD-A27290375-001-01-8

C01479

C17H23NO3

CAS-120-29-6

CCRIS 3080

CHEBI:15742

CHEBI:15884

CHEBI:16684

CHEBI:537621

CHEBI:57858

CHEMBL1235490

CID174174

CPD001906768

Cytospaz

D00113

d1-hyoscyamine

DB00572

DB04026

dl-Hyoscyamine

DL-Hyoscyamine

DL-Tropanyl 2-hydroxy-1-phenylpropionate

DL-Tropyl tropate

dl-tropyltropate

dl-Tropyltropate

DL-Tropyltropate

DL-Tropyltropic acid

EINECS 200-104-8

endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol

Eyesules

FT-0082634

HMS2089A16

HSDB 2199

hyoscyamine

Hyoscyamine sulfate

Isopto Atropine

Isopto-atropine

I-Tropine

LS-7203

MEGxp0_001878

Minims

Minims Atropine

MLS000069795

MLS001148094

MLS002695888

MolPort-001-742-593

MolPort-003-986-158

NCGC00016370-01

NCGC00142514-01

NCGC00142514-03

nchembio.307-comp21

Neo-Diophen

NP-010662

Ocu-Tropine

OR22908

Protamine & Atropine

SAM002554885

SMR000058248

ST057178

ST057655

T0534

TL8000018

tropan-3alpha-ol

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate

tropan-3beta-ol

Tropanol

Tropic acid, 3-alpha-tropanyl ester

Tropic acid, ester with tropine

Tropine (+/-)-tropate

Tropine tropate

Tropine tropic acid

Tropine, tropate (ester)

Troyl tropate

Urised

Respiratory System Agents

Parasympatholytics

Anti-Asthmatic Agents

Neurotransmitter Agents

Cholinergic Antagonists

Anesthetics

Mydriatics

Cholinergic Agents

Muscarinic Antagonists

Bronchodilator Agents

Anti-Arrhythmia Agents

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease	Completed	NCT00865501	Phase 3	spironolactone;placebo
2	Role of ARNi in Ventricular Remodeling in Hypertensive LVH	Recruiting	NCT03553810	Phase 3	Entresto;Valsartan
3	E_Stethoscope : Portable Digital Auscultation Based on Wireless Sensor Node to Diagnose Diastolic Dysfunction in Hypertensive Heart Disease	Unknown status	NCT02809040
4	Asian American Partnerships in Research and Empowerment (AsPIRE)	Completed	NCT03100812
5	The Personalized Chinese Herb Formulas Are Evaluated for Their Effectiveness to Relieve Symptoms in Hypertensive Bradyarrhythmia	Completed	NCT04505228		Safflower (Carthamus Tinctorius) IgG4 &#X7C; Serum &#X7C; Allergy;Atropine Sulfate
6	Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease	Completed	NCT03476785
7	Relationship Between Arteriosclerosis and Myocardial Work in Hypertensive Patients With Left Ventricular Ejection Fraction Retention	Recruiting	NCT04573257
8	Registro Campania Salute Network for the Treatment of Hypertension and Correlated Diseases	Recruiting	NCT02211365
9	Renal Sympathetic Denervation Restores Autonomic Imbalance and Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study	Active, not recruiting	NCT01990911		Medical therapy
10	EARLY Differentiation of MYOcardial Hypertrophy From Hypertensive Heart Disease: a Multi-center, Prospective, Controlled Clinical Trial	Active, not recruiting	NCT03271385
11	The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study	Enrolling by invitation	NCT04190420
12	Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline	Not yet recruiting	NCT04682977

Search NIH Clinical Center for Hypertensive Heart Disease

Sources

Genetic Tests for Hypertensive Heart Disease

Sources

Anatomical Context for Hypertensive Heart Disease

MalaCards organs/tissues related to Hypertensive Heart Disease:

⁴⁰

Heart, Kidney, Brain, Endothelial, Bone Marrow, Cardiac Myocytes, Eye

Sources

Publications for Hypertensive Heart Disease

Articles related to Hypertensive Heart Disease:

(show top 50) (show all 1605)

#	Title	Authors	PMID	Year
1	Relation of circulating markers of fibrosis and progression of left and right ventricular dysfunction in hypertensive patients with heart failure. ⁶¹ ⁵⁴	Plaksej R...Weidemann F	19887955	2009
2	Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. ⁵⁴ ⁶¹	Huang M...He J	19117407	2009
3	Mineralocorticoid signaling in transition to heart failure with normal ejection fraction. ⁵⁴ ⁶¹	Shapiro BP...Redfield MM	18086943	2008
4	Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. ⁵⁴ ⁶¹	Kato M...Kitakaze M	17127817	2006
5	Measurements of baseline and follow-up concentrations of cardiac troponin-T and brain natriuretic peptide in patients with heart failure from various etiologies. ⁶¹ ⁵⁴	Taniguchi R...Kita T	17143708	2006
6	Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease. ⁵⁴ ⁶¹	Goikoetxea MJ...Diez J	16371224	2006
7	Comparison of positive cases for B-type natriuretic peptide and ECG testing for identification of precursor forms of heart failure in an elderly population. ⁵⁴ ⁶¹	Nakamura M...Hiramori K	16043943	2005
8	Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. ⁵⁴ ⁶¹	Querejeta R...Diez J	15313958	2004
9	Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. ⁶¹ ⁵⁴	Ogata T...Yamaguchi I	15093887	2004
10	Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis. ⁵⁴ ⁶¹	Lopez B...Diez J	15202614	2004
11	Peroxisome proliferator-activated receptor alpha and hypertensive heart disease. ⁶¹ ⁵⁴	Goikoetxea MJ...Diez J	15765888	2004
12	The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives. ⁵⁴ ⁶¹	Diez J...Beloqui O	14597852	2003
13	Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. ⁶¹ ⁵⁴	Shi SJ...Pandey KN	12824076	2003
14	Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease. ⁵⁴ ⁶¹	Dean DE...Powers RH	11569573	2001
15	Renin-angiotensin system inhibition improves coronary flow reserve in hypertension. ⁶¹ ⁵⁴	Frohlich ED	11392478	2001
16	Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. ⁵⁴ ⁶¹	Schwartzkopff B...Strauer BE	10948081	2000
17	AT1 receptors: coronary flow and flow reserve. ⁵⁴ ⁶¹	Frohlich ED	10678287	2000
18	[Hypertensive heart disease with left ventricular diastolic dysfunction demonstrating restrictive hemodynamics: a case report]. ⁵⁴ ⁶¹	Soeki T...Tamura Y	10396707	1999
19	Angiotensin converting enzyme inhibition by captopril influences cardiac work in healthy hearts. ⁶¹ ⁵⁴	Derad I...Born J	9832171	1998
20	Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. ⁶¹ ⁵⁴	Oliver PM...Maeda N	9405681	1997
21	Effects of moexiprilat on oestrogen-stimulated cardiac fibroblast growth. ⁵⁴ ⁶¹	Grohe C...Neyses L	9257913	1997
22	Marked expression of plasma brain natriuretic peptide is a special feature of hypertrophic obstructive cardiomyopathy. ⁶¹ ⁵⁴	Nishigaki K...Fujiwara H	8890821	1996
23	Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. ⁵⁴ ⁶¹	Brilla CG...Weber KT	8518539	1993
24	Texture analysis applied in T1 maps and extracellular volume obtained using cardiac MRI in the diagnosis of hypertrophic cardiomyopathy and hypertensive heart disease compared with normal controls. ⁶¹	Shi RY...Wu LM	33272531	2021
25	Hypertension, Prehypertension, Hypertensive Heart Disease, and Atrial Fibrillation. ⁶¹	Lau DH...Shenasa M	33516406	2021
26	Oxygenation-Sensitive Cardiovascular Magnetic Resonance in Hypertensive Heart Disease With Left Ventricular Myocardial Hypertrophy and Non-Left Ventricular Myocardial Hypertrophy: Insight From Altered Mechanics and Cardiac BOLD Imaging. ⁶¹	Chen BH...Wu LM	33068066	2021
27	Cardiac magnetic resonance imaging features prognostic information in patients with suspected myocardial infarction with non-obstructed coronary arteries. ⁶¹	Emrich T...Kreitner KF	33309758	2021
28	Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017. ⁶¹	Bragazzi NL...Dai H	33571994	2021
29	Estimation and determinants of direct medical costs of ischaemic heart disease, stroke and hypertensive heart disease: evidence from two major hospitals in Cameroon. ⁶¹	Aminde LN...Veerman JL	33579273	2021
30	Description of multimorbidity clusters of admitted patients in medical departments of a general hospital. ⁶¹	Matesanz-Fernandez M...Casariego-Vales E	33547138	2021
31	The Effect of Antihypertensive Therapy on Left Ventricular Longitudinal Strain: Missing Part of the Puzzle. ⁶¹	Tadic M...Cuspidi C	32086702	2021
32	Worldwide Trends in Prevalence, Mortality, and Disability-Adjusted Life Years for Hypertensive Heart Disease From 1990 to 2017. ⁶¹	Dai H...Grossman E	33583201	2021
33	Breastfeeding Challenges: ACOG Committee Opinion, Number 820. ⁶¹		33481531	2021
34	Breastfeeding Challenges: ACOG Committee Opinion Summary, Number 820. ⁶¹		33481526	2021
35	Left ventricular mass reduction and hypertrophy regression following renal artery revascularization: a meta-analysis. ⁶¹	Cuspidi C...Grassi G	32833917	2021
36	Left atrial strain imaging differentiates cardiac amyloidosis and hypertensive heart disease. ⁶¹	Rausch K...Chan J	32728989	2021
37	Prevalence of rheumatic heart disease in a major referral cardiology clinic in Ethiopia: A retrospective cross-sectional study. ⁶¹	Asmare MH...Vanrumste B	33592020	2021
38	Artificial intelligence-based myocardial texture analysis in etiological differentiation of left ventricular hypertrophy. ⁶¹	Yu F...Zhang B	33569410	2021
39	Maternal cardiovascular risk after hypertensive disorder of pregnancy. ⁶¹	Arnott C...Woodward M	32404402	2020
40	Orthogonal electrical cardioversion in atrial fibrillation refractory to biphasic shocks: a case series. ⁶¹	Velazquez-Rodriguez E...Rangel-Rojo FJ	33442616	2020
41	Sacubitril/Valsartan Inhibits Cardiomyocyte Hypertrophy in Angiotensin II-Induced Hypertensive Mice Independent of a Blood Pressure-Lowering Effect. ⁶¹	Tashiro K...Miura SI	33224383	2020
42	A case report of an infiltrative cardiomyopathy in everyday practice: a specific cause that cannot be missed in the elderly. ⁶¹	Chiou A...Kesarwani M	33442642	2020
43	Physical Exercise Combined with Antihypertensive Drug Therapy on Left Ventricular Hypertrophy: Systematic Review and Meta-Analysis. ⁶¹	de Castro QJT...Grabe-Guimaraes A	32776302	2020
44	Histological features of endomyocardial biopsies in patients undergoing hemodialysis: Comparison with dilated cardiomyopathy and hypertensive heart disease. ⁶¹	Yoshizawa S...Oda H	32721819	2020
45	Changes in the number of mast cells, expression of fibroblast growth factor-2 and extent of interstitial fibrosis in established and advanced hypertensive heart disease. ⁶¹	Kotov G...Iliev A	32603827	2020
46	Burden of cause-specific mortality attributable to heat and cold: A multicity time-series study in Jiangsu Province, China. ⁶¹	Ma Y...Chen K	32745780	2020
47	The value of multimodality imaging in hypertensive heart disease. ⁶¹	Saeed S...Larsen TH	33239554	2020
48	Cellular contribution to left and right atrial dysfunction in chronic arterial hypertension in pigs. ⁶¹	Jin G...Heinzel FR	33251761	2020
49	Epidemiology of acutely decompensated systolic heart failure over the 2003-2013 decade in Douala General Hospital, Cameroon. ⁶¹	Lemogoum D...van de Borne P	33225620	2020
50	Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. ⁶¹	Meijles DN...Clerk A	32903101	2020

Sources

Genes for Hypertensive Heart Disease

Genes related to Hypertensive Heart Disease (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ACE	Angiotensin I Converting Enzyme	Protein Coding	22.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19117407 11569573 8518539 (more) 9832171 9257913 10948081 15093864 11392478
2	NPPB	Natriuretic Peptide B	Protein Coding	21.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17143708 16043943 17127817 (more) 10396707
3	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	18.45	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10678287
4	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	17.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18086943
5	MMP1	Matrix Metallopeptidase 1	Protein Coding	17.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15202614
6	CD36	CD36 Molecule	Protein Coding	13.58	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15313958 14597852 19887955
7	CTF1	Cardiotrophin 1	Protein Coding	13.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	MMP9	Matrix Metallopeptidase 9	Protein Coding	12.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	12.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	MMP2	Matrix Metallopeptidase 2	Protein Coding	12.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	AGT	Angiotensinogen	Protein Coding	12.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	12.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CASP3	Caspase 3	Protein Coding	11.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	11.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9405681 12824076
15	FGF2	Fibroblast Growth Factor 2	Protein Coding	11.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TPM1	Tropomyosin 1	Protein Coding	11.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	IGF1	Insulin Like Growth Factor 1	Protein Coding	10.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	MSTN	Myostatin	Protein Coding	10.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	ANXA5	Annexin A5	Protein Coding	10.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	NPPA	Natriuretic Peptide A	Protein Coding	10.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8890821 10396707
21	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	7.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15765888 15093887 16371224
22	REN	Renin	Protein Coding	7.34	DISEASES inferred ¹⁵
23	AOC3	Amine Oxidase Copper Containing 3	Protein Coding	6.91	GeneCards inferred via : Publications (show sections)

Sources

Variations for Hypertensive Heart Disease

Sources

Expression for Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Sources

Pathways for Hypertensive Heart Disease

Pathways related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.3	MMP9 MMP2 MMP1 FGF2 CTF1 CD36
2	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	12.98	TIMP2 IGF1 FGF2 AGTR1 AGT ACE
3	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.67	TIMP2 MMP9 MMP2 MMP1 FGF2 CASP3
4	Pathways in cancer ³⁶	12.58	MMP9 MMP2 MMP1 IGF1 FGF2 CASP3
5	Oxytocin signaling pathway ³⁶ Show member pathways Vascular smooth muscle contraction ³⁶	12.43	NPR1 NPPB NPPA AGTR1 AGT
6	cGMP-PKG signaling pathway ³⁶ Show member pathways Adrenergic signaling in cardiomyocytes ³⁶	12.41	TPM1 NPR1 NPPB NPPA AGTR1 AGT
7	Proteoglycans in cancer ³⁶	12.19	MMP9 MMP2 IGF1 FGF2 CASP3
8	Dilated cardiomyopathy ³⁶ Show member pathways Hypertrophic cardiomyopathy ³⁶	12.18	TPM1 IGF1 AGT ACE
9	Colorectal Cancer Metastasis ⁶³	12.12	MMP9 MMP2 MMP1 CASP3
10	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.87	MMP2 CASP3 AGTR1 AGT
11	Interleukin-4 and 13 signaling ⁶⁵	11.86	MMP9 MMP2 MMP1 FGF2 CD36
12	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁵ Inhibition of Matrix Metalloproteinases ⁶³	11.85	TIMP2 MMP9 MMP2 MMP1
13	Angiogenesis (CST) ⁴	11.76	TIMP2 MMP9 MMP2 FGF2
14	Bladder cancer ³⁶ ¹	11.68	MMP9 MMP2 MMP1
15	AGE/RAGE pathway ¹	11.63	MMP9 MMP2 CASP3
16	MicroRNAs in cardiomyocyte hypertrophy ¹ Show member pathways Cardiac Hypertrophic Response ¹	11.63	NPPB NPPA IGF1 FGF2 CTF1 AGT
17	LPA receptor mediated events ¹	11.62	MMP9 MMP2 CASP3
18	ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE Inhibitor Pathway ¹ Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Renin-angiotensin system ³⁶	11.62	NR3C2 CYP11B2 AGTR1 AGT ACE
19	Endochondral Ossification ¹	11.61	MMP9 IGF1 FGF2
20	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.59	MMP9 MMP2 MMP1
21	Lung fibrosis ¹	11.56	MMP9 MMP2 IGF1 FGF2
22	Renin secretion ³⁶	11.39	NPR1 NPPA AGTR1 AGT ACE
23	Cell adhesion_Cell-matrix glycoconjugates ²³	11.36	TIMP2 MMP9 MMP1
24	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	11.29	MMP9 MMP2 MMP1
25	A-beta Pathways: Uptake and Degradation ⁶⁴	11.17	MMP9 MMP2 CD36 ACE
26	Angiogenesis (WikiPathways) ¹	11.1	TIMP2 MMP9 FGF2
27	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁴	11.06	MMP9 MMP2 ACE
28	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁵	10.99	MMP2 MMP1 IGF1
29	Cell adhesion_ECM remodeling ²³	10.81	TIMP2 MMP9 MMP2 MMP1 IGF1

Sources

GO Terms for Hypertensive Heart Disease

Cellular components related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.77	TIMP2 NPPB NPPA MSTN MMP9 MMP2
2	collagen-containing extracellular matrix	GO:0062023	9.63	TIMP2 NPPA MMP9 MMP2 ANXA5 AGT
3	extracellular matrix	GO:0031012	9.56	TIMP2 MMP9 MMP2 MMP1
4	extracellular space	GO:0005615	9.4	TIMP2 NPPB NPPA MSTN MMP9 MMP2

Biological processes related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 37)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.99	NPR1 NPPB CTF1 CD36 AGT
2	extracellular matrix organization	GO:0030198	9.96	MMP9 MMP2 MMP1 FGF2
3	cellular protein metabolic process	GO:0044267	9.95	NPPA MMP2 MMP1 IGF1
4	negative regulation of cell growth	GO:0030308	9.88	NPR1 NPPB NPPA AGT
5	positive regulation of MAPK cascade	GO:0043410	9.87	TIMP2 IGF1 FGF2 CD36
6	wound healing	GO:0042060	9.85	TPM1 IGF1 FGF2 CASP3
7	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.84	IGF1 CD36 AGT
8	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.84	IGF1 FGF2 AGT
9	regulation of cardiac conduction	GO:1903779	9.8	NPR1 NPPA AGT
10	extracellular matrix disassembly	GO:0022617	9.8	TIMP2 MMP9 MMP2 MMP1
11	collagen catabolic process	GO:0030574	9.79	MMP9 MMP2 MMP1
12	cellular response to reactive oxygen species	GO:0034614	9.77	TPM1 MMP9 MMP2
13	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.73	CD36 AGTR1 AGT
14	regulation of vasoconstriction	GO:0019229	9.7	AGTR1 AGT ACE
15	cytokine-mediated signaling pathway	GO:0019221	9.7	MMP9 MMP2 MMP1 FGF2 CTF1 CD36
16	positive regulation of macrophage derived foam cell differentiation	GO:0010744	9.69	CD36 AGTR1 AGT
17	response to amyloid-beta	GO:1904645	9.67	MMP9 MMP2
18	positive regulation of urine volume	GO:0035810	9.67	NPR1 NPPB
19	negative regulation of systemic arterial blood pressure	GO:0003085	9.66	NPPB NPPA
20	regulation of vascular permeability	GO:0043114	9.65	NPR1 NPPB
21	positive regulation of renal sodium excretion	GO:0035815	9.65	NPR1 NPPB AGT
22	regulation of blood pressure	GO:0008217	9.65	NPR1 NPPB NPPA AGT ACE
23	positive regulation of cholesterol esterification	GO:0010873	9.64	AGTR1 AGT
24	positive regulation of cGMP-mediated signaling	GO:0010753	9.64	NPR1 NPPA
25	body fluid secretion	GO:0007589	9.63	NPR1 NPPB
26	positive regulation of NAD(P)H oxidase activity	GO:0033864	9.63	AGTR1 AGT
27	cellular response to UV-A	GO:0071492	9.63	MMP9 MMP2 MMP1
28	regulation of blood vessel diameter	GO:0097746	9.62	NPR1 NPPB AGTR1 ACE
29	regulation of renal sodium excretion	GO:0035813	9.61	AGTR1 AGT
30	renin-angiotensin regulation of aldosterone production	GO:0002018	9.61	AGTR1 AGT
31	cGMP biosynthetic process	GO:0006182	9.61	NPR1 NPPB NPPA
32	regulation of blood vessel diameter by renin-angiotensin	GO:0002034	9.58	AGTR1 AGT
33	receptor guanylyl cyclase signaling pathway	GO:0007168	9.58	NPR1 NPPB NPPA
34	regulation of renal output by angiotensin	GO:0002019	9.54	AGT ACE
35	regulation of systemic arterial blood pressure by renin-angiotensin	GO:0003081	9.54	AGTR1 AGT ACE
36	cGMP-mediated signaling	GO:0019934	9.26	NPR1 NPPB NPPA CD36
37	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	9.02	MMP9 MMP2 IGF1 FGF2 AGT

Molecular functions related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	zinc ion binding	GO:0008270	9.88	TIMP2 NR3C2 MMP9 MMP2 MMP1 ACE
2	peptidase activity	GO:0008233	9.83	MMP9 MMP2 MMP1 CASP3 ACE
3	metallopeptidase activity	GO:0008237	9.62	MMP9 MMP2 MMP1 ACE
4	growth factor activity	GO:0008083	9.56	MSTN IGF1 FGF2 AGT
5	hormone activity	GO:0005179	9.46	NPPB NPPA IGF1 AGT
6	hormone receptor binding	GO:0051427	9.37	NPPB NPPA
7	bradykinin receptor binding	GO:0031711	8.96	AGTR1 ACE
8	endopeptidase activity	GO:0004175	8.92	MMP9 MMP2 MMP1 ACE

Sources

Sources for Hypertensive Heart Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia