MCID: HYP006
MIFTS: 50

Hypertensive Heart Disease

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Hypertensive Heart Disease

MalaCards integrated aliases for Hypertensive Heart Disease:

Name: Hypertensive Heart Disease 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11516
ICD10 33 I11 I11.9 I11.0
ICD9CM 35 402 402.9
SNOMED-CT 68 64715009
UMLS 73 C0152105

Summaries for Hypertensive Heart Disease

Disease Ontology : 12 A heart disease that is caused by high blood pressure.

MalaCards based summary : Hypertensive Heart Disease is related to heart disease and coronary artery anomaly. An important gene associated with Hypertensive Heart Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Pathways in cancer and Colorectal Cancer Metastasis. The drugs Angiotensin II and Irbesartan have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Hypertensive heart disease includes a number of complications of high blood pressure that affect the... more...

Related Diseases for Hypertensive Heart Disease

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 heart disease 31.6 ACE AGTR1 CD36 NPPB
2 coronary artery anomaly 30.2 ACE AGTR1 NPPB
3 atrial fibrillation 30.1 ACE AGT AGTR1 NPPB
4 coronary heart disease 1 29.9 ACE AGTR1 NPPB
5 nephrosclerosis 29.9 ACE AGTR1 NR3C2
6 mitral valve insufficiency 29.8 ACE NPPB
7 renal dysplasia 29.6 ACE AGT AGTR1
8 arteries, anomalies of 29.6 ACE AGT AGTR1 MMP9 NPPB
9 diastolic heart failure 29.6 ACE AGT AGTR1 MMP2 NPPB
10 kidney disease 29.3 ACE AGT AGTR1 NPPB NR3C2
11 congestive heart failure 29.3 ACE AGTR1 NPPB NPR1 NR3C2
12 hypertension, essential 28.8 ACE AGT AGTR1 CYP11B2 NPPB NPR1
13 myocardial infarction 28.4 ACE AGT AGTR1 CTF1 MMP2 MMP9
14 dilated cardiomyopathy 28.2 ACE AGT AGTR1 CTF1 CYP11B2 MMP1
15 hypertrophic cardiomyopathy 10.4
16 anterolateral myocardial infarction 10.2 ACE NPPB
17 left bundle branch hemiblock 10.2 ACE NPPB
18 syndrome of inappropriate antidiuretic hormone 10.2 ACE NPPB
19 pediatric hypertension 10.2 ACE AGT
20 hypertensive nephropathy 10.2 ACE AGTR1
21 ischemic heart disease 10.2 ACE NPPB
22 keloids 10.2 CD36 MMP1
23 aortic valve insufficiency 10.2 ACE NPPB
24 renal hypertension 10.1 ACE AGTR1 NPPB
25 idiopathic edema 10.1 ACE NPPB NR3C2
26 systolic heart failure 10.1 ACE NPPB NR3C2
27 ischemia 10.1
28 meningococcal infection 10.1 AGT AGTR1
29 conjunctivochalasis 10.1 MMP1 MMP2
30 hypertrophic scars 10.1 CD36 MMP2
31 chronic actinic dermatitis 10.1 MMP1 MMP9
32 renal fibrosis 10.1 AGTR1 CD36 NR3C2
33 chromoblastomycosis 10.1 MMP1 MMP9
34 aortic valve disease 2 10.1 ACE AGT NPPB
35 renovascular hypertension 10.1 ACE AGTR1
36 adult astrocytic tumour 10.1 MMP1 MMP9
37 renal artery disease 10.1 ACE AGT AGTR1
38 posterior urethral valves 10.1 ACE AGT AGTR1
39 microvascular complications of diabetes 3 10.1 ACE AGT AGTR1
40 malignant hypertension 10.1 ACE AGT AGTR1
41 fibromuscular dysplasia 10.1 ACE AGT AGTR1
42 renal tubular dysgenesis 10.1 ACE AGT AGTR1
43 fibromatosis, gingival, 1 10.1 CD36 MMP1 MMP2
44 ischemic optic neuropathy 10.1 ACE AGT AGTR1
45 end stage renal failure 10.0 ACE AGT AGTR1
46 gingival fibromatosis 10.0 CD36 MMP1 MMP2
47 septic arthritis 10.0 MMP1 MMP2
48 angina pectoris 10.0 ACE NPPB
49 gingival overgrowth 10.0 CD36 MMP1 MMP2
50 extracranial arteriovenous malformation 10.0 MMP2 MMP9

Comorbidity relations with Hypertensive Heart Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to Hypertensive Heart Disease

Symptoms & Phenotypes for Hypertensive Heart Disease

MGI Mouse Phenotypes related to Hypertensive Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACE AGT AGTR1 CD36 CYP11B2 MMP2
2 homeostasis/metabolism MP:0005376 10.11 ACE AGT AGTR1 CD36 CTF1 CYP11B2
3 growth/size/body region MP:0005378 10.09 ACE AGT AGTR1 CD36 CTF1 CYP11B2
4 hematopoietic system MP:0005397 10.01 ACE AGTR1 CD36 CYP11B2 MMP2 MMP9
5 immune system MP:0005387 9.97 ACE AGT AGTR1 CD36 CYP11B2 MMP1
6 adipose tissue MP:0005375 9.95 ACE AGT AGTR1 CD36 CTF1 CYP11B2
7 muscle MP:0005369 9.73 AGT CD36 MMP2 MMP9 NPR1 NR3C2
8 nervous system MP:0003631 9.56 AGT AGTR1 CD36 CTF1 CYP11B2 MMP2
9 neoplasm MP:0002006 9.55 ACE MMP1 MMP2 MMP9 NPR1
10 renal/urinary system MP:0005367 9.17 ACE AGT AGTR1 CD36 CYP11B2 MMP9

Drugs & Therapeutics for Hypertensive Heart Disease

Drugs for Hypertensive Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
2
Irbesartan Approved, Investigational Phase 4,Phase 2,Phase 3 138402-11-6 3749
3
Ramipril Approved Phase 4 87333-19-5 5362129
4 Antihypertensive Agents Phase 4,Phase 2,Phase 3
5 Angiotensin Receptor Antagonists Phase 4,Phase 2,Phase 3
6 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 2,Phase 3
7 Angiotensinogen Phase 4,Phase 2,Phase 3
8 HIV Protease Inhibitors Phase 4
9
protease inhibitors Phase 4
10 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 3
11
Spironolactone Approved Phase 3 52-01-7, 1952-01-7 5833
12
Atenolol Approved Phase 2, Phase 3 29122-68-7 2249
13
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
14
Enalaprilat Approved Phase 3 76420-72-9 6917719
15
Amlodipine Approved Phase 3 88150-42-9 2162
16
Valsartan Approved, Investigational Phase 3 137862-53-4 60846
17
Hydrochlorothiazide Approved, Vet_approved Phase 3 58-93-5 3639
18 diuretics Phase 3,Not Applicable
19 Diuretics, Potassium Sparing Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Mineralocorticoids Phase 3
22 Mineralocorticoid Receptor Antagonists Phase 3
23 Hormone Antagonists Phase 3
24 Hormones Phase 3
25 Natriuretic Agents Phase 3
26 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
27 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
28 Neurotransmitter Agents Phase 2, Phase 3
29 Adrenergic beta-Antagonists Phase 2, Phase 3
30 Adrenergic Agents Phase 2, Phase 3
31 Sympatholytics Phase 2, Phase 3
32 Anti-Arrhythmia Agents Phase 2, Phase 3
33 Adrenergic Antagonists Phase 2, Phase 3
34 Autonomic Agents Phase 2, Phase 3
35 LCZ 696 Phase 3
36 Sodium Chloride Symporter Inhibitors Phase 3
37 Pharmaceutical Solutions Phase 2
38
Resveratrol Approved, Experimental, Investigational Phase 1 501-36-0 445154
39 Grape Approved Phase 1
40
Quercetin Experimental, Investigational Phase 1 117-39-5 5280343
41 Antioxidants Phase 1,Not Applicable
42 Anti-Inflammatory Agents, Non-Steroidal Phase 1
43 Anthocyanidin Phase 1
44 Analgesics Phase 1
45 Anti-Inflammatory Agents Phase 1
46 Antirheumatic Agents Phase 1
47 Antineoplastic Agents, Phytogenic Phase 1
48 Analgesics, Non-Narcotic Phase 1
49 Protective Agents Phase 1
50 Grape Seed Extract Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan Unknown status NCT00517322 Phase 4 ramipril;irbesartan
2 Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease Completed NCT00865501 Phase 3 spironolactone;placebo
3 Irbesartan and Atenolol in Hypertensive Heart Disease Completed NCT00389168 Phase 2, Phase 3 Irbesartan;Atenolol
4 Studies of Left Ventricular Dysfunction (SOLVD) Completed NCT00000516 Phase 3 enalapril
5 Role of ARNi in Ventricular Remodeling in Hypertensive LVH Not yet recruiting NCT03553810 Phase 3 Entresto;Valsartan
6 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
7 Physiological Effects of Grape Seed Extract in Diastolic Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
8 REMODEL: Hypertensive Heart Disease Unknown status NCT02670031
9 Clinical Research to Explore Manifestations of Heart Failure Using Infrared Thermal Imaging Technology Unknown status NCT02672618
10 Asian American Partnerships in Research and Empowerment (AsPIRE) Completed NCT03100812 Not Applicable
11 Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure Completed NCT00939640 Not Applicable
12 Vitamin D Therapy to Reduce Cardiac Damage Among Vulnerable Hypertensive Patients Completed NCT01360476 Not Applicable
13 Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR Completed NCT00811668 Not Applicable
14 Differentiating Hypertrophic Cardiomyopathy From Hypertensive Heart Disease Recruiting NCT03271385
15 Renal Sympathetic Denervation Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study Recruiting NCT01990911 Not Applicable Medical therapy
16 Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease Recruiting NCT03476785 Not Applicable
17 Outcome of Different Pathogenic Mutations in Hypertrophic Cardiomyopathy Recruiting NCT03726424
18 E_Stethoscope: Portable Digital Auscultation Study on Hypertensive/Hypertensive Heart Disease Patients Active, not recruiting NCT02809040
19 Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2) Terminated NCT01942395 Not Applicable

Search NIH Clinical Center for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

Anatomical Context for Hypertensive Heart Disease

MalaCards organs/tissues related to Hypertensive Heart Disease:

41
Heart, Bone, Testes, Brain, Kidney, Cortex, Adrenal Gland

Publications for Hypertensive Heart Disease

Articles related to Hypertensive Heart Disease:

(show top 50) (show all 405)
# Title Authors Year
1
Extracellular volume by cardiac magnetic resonance is associated with biomarkers of inflammation in hypertensive heart disease. ( 30063646 )
2019
2
An essential role for Wnt/I^-catenin signaling in mediating hypertensive heart disease. ( 29895976 )
2018
3
Three-dimensional echocardiography: a further step in the evaluation of hypertensive heart disease. ( 29952849 )
2018
4
Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease. ( 29449707 )
2018
5
Oxygenation-sensitive cardiovascular magnetic resonance in hypertensive heart disease with left ventricular myocardial hypertrophy and non-left ventricular myocardial hypertrophy: Insight from altered mechanics and cardiac BOLD imaging. ( 29734491 )
2018
6
Limited Impact of β-Adrenergic Receptor Activation on Left Ventricular Diastolic Function in Rat Models of Hypertensive Heart Disease. ( 30403389 )
2018
7
Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats. ( 30456794 )
2018
8
Empagliflozin reduces myocardial ketone utilization while preserving glucose utilization in diabetic hypertensive heart disease: A hyperpolarized 13 C magnetic resonance spectroscopy study. ( 30225964 )
2018
9
Hypertensive heart disease beyond left ventricular hypertrophy: are we ready for echocardiographic strain evaluation in everyday clinical practice? ( 29227376 )
2017
10
Cardiac magnetic resonance imaging provides new insight into hypertensive heart disease-a reply. ( 28139052 )
2017
11
Fragmented QRS: A marker of hypertensive heart disease? ( 28721702 )
2017
12
Histamine-2 receptor antagonist famotidine modulates cardiac stem cell characteristics in hypertensive heart disease. ( 29038754 )
2017
13
Regression of Established Cardiac Fibrosis in Hypertensive Heart Disease. ( 28379281 )
2017
14
Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging. ( 28373647 )
2017
15
A predominance of hypertensive heart disease among patients with cardiac disease in Buea, a semi-urban setting, South West Region of Cameroon. ( 29202813 )
2017
16
The emerging role of Cardiovascular Magnetic Resonance in the evaluation of hypertensive heart disease. ( 28535761 )
2017
17
Heart Failure WithA Preserved EjectionA Fraction: A Late Stage of Hypertensive Heart Disease. ( 29096816 )
2017
18
Relaxation and the Role of Calcium in Isolated Contracting Myocardium From Patients With Hypertensive Heart Disease and Heart Failure With Preserved Ejection Fraction. ( 28784688 )
2017
19
Hypertrophic cardiomyopathy and left ventricular hypertrophy in hypertensive heart disease with mildly reduced or preserved ejection fraction: insight from altered mechanics and native T1 mapping. ( 28552325 )
2017
20
MiR-19b and miR-16 cooperatively signaling target the regulator ADRA1A in Hypertensive heart disease. ( 28531963 )
2017
21
Comparison of Pulmonary Venous and Left Atrial Remodeling in Patients With Atrial Fibrillation With Hypertrophic Cardiomyopathy Versus With Hypertensive Heart Disease. ( 28214001 )
2017
22
Carotid artery intima-media thickness and hypertensive heart disease: a short review. ( 28373912 )
2017
23
Reply: Heart Failure With Preserved EjectionA Fraction: A Late Stage of Hypertensive Heart Disease. ( 29096817 )
2017
24
High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats. ( 28888352 )
2017
25
Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway. ( 28971696 )
2017
26
NT-pro BNP and plasma-soluble ST2 as promising biomarkers for hypertension, hypertensive heart disease and heart failure in sub-Saharan Africa. ( 29297544 )
2017
27
Cardiac magnetic resonance imaging provides a new insight in hypertensive heart disease. ( 28139099 )
2017
28
Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. ( 28630342 )
2017
29
A Novel Index of Remodeling in Hypertensive Heart Disease. ( 28847912 )
2017
30
Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry. ( 26766206 )
2016
31
JS ISH-ESH-2 UPDATE ON THE DETECTION AND FOLLOW-UP OF EARLY HYPERTENSIVE HEART DISEASE. ( 27642917 )
2016
32
The interplay between renin-angiotensin system activation, abnormal myocardial deformation and neurohumoral activation in hypertensive heart disease: a speckle tracking echocardiography study. ( 27787699 )
2016
33
Electrocardiography for Assessment of Hypertensive Heart Disease: A New Role for an Old Tool. ( 27160048 )
2016
34
Recurrent Syncope: An Unusual Complication of Hypertensive Heart Disease. ( 27448490 )
2016
35
SY 05-2 PROGRESSION OF HYPERTENSIVE HEART DISEASE: NEW THERAPEUTIC APPROACH. ( 27753836 )
2016
36
The septal bulge-an early echocardiographic sign in hypertensive heart disease. ( 26850524 )
2016
37
Factors associated to hypertensive heart disease development: a prospective cohort study in Bayamo, Cuba. ( 27571318 )
2016
38
Cardiac Fibrosis in Aortic Stenosis and Hypertensive Heart Disease Assessed by Magnetic Resonance T1 Mapping. ( 28238233 )
2016
39
The Relationship Between Left Ventricular Wall Thickness, Myocardial Shortening, and Ejection Fraction in Hypertensive Heart Disease: Insights From Cardiac Magnetic Resonance Imaging. ( 27316563 )
2016
40
Effect of Renal Sympathetic Denervation on Specific MicroRNAs as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease. ( 26916982 )
2016
41
Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy. ( 27142065 )
2016
42
Case 2/2016 - 76-Year-Old Male with Hypertensive Heart Disease, Renal Tumor and Shock. ( 27305288 )
2016
43
SY 05-2 PROGRESSION OF HYPERTENSIVE HEART DISEASE: NEW THERAPEUTIC APPROACH. ( 27642889 )
2016
44
JS ISH-ESH-2 UPDATE ON THE DETECTION AND FOLLOW-UP OF EARLY HYPERTENSIVE HEART DISEASE. ( 27754006 )
2016
45
Comprehensive characterisation of hypertensive heart disease left ventricular phenotypes. ( 27260191 )
2016
46
Hypertensive heart disease versus hypertrophic cardiomyopathy: multi-parametric cardiovascular magnetic resonance discriminators when end-diastolic wall thickness a8Y 15 mm. ( 27368925 )
2016
47
Aircraft, road and railway traffic noise as risk factors for heart failure and hypertensive heart disease-A case-control study based on secondary data. ( 27667192 )
2016
48
Fragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease. ( 27774963 )
2016
49
Prognostic Implications of LV Strain RiskA ScoreA inA Asymptomatic Patients WithA Hypertensive Heart Disease. ( 27344417 )
2016
50
Screening and Treatment for Subclinical Hypertensive Heart Disease in Emergency Department Patients With Uncontrolled Blood Pressure: A Cost Effectiveness Analysis. ( 27797437 )
2016

Variations for Hypertensive Heart Disease

Expression for Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for Hypertensive Heart Disease

Pathways related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.6 AGTR1 MMP1 MMP2 MMP9
2 11.94 MMP1 MMP2 MMP9
3
Show member pathways
11.91 AGT CTF1 NPPB
4
Show member pathways
11.77 CD36 MMP2 MMP9
5 11.68 CD36 MMP1 MMP2 MMP9
6
Show member pathways
11.65 MMP1 MMP2 MMP9
7 11.5 MMP1 MMP2 MMP9
8
Show member pathways
11.41 MMP1 MMP2 MMP9
9 11.37 MMP1 MMP2 MMP9
10 11.27 ACE AGT AGTR1 NPR1
11 11.08 MMP1 MMP2 MMP9
12 10.98 MMP2 MMP9
13 10.96 AGT CTF1
14
Show member pathways
10.92 ACE AGT AGTR1 CYP11B2 NR3C2
15 10.85 MMP1 MMP2
16 10.79 ACE MMP2 MMP9
17 10.76 ACE CD36 MMP2 MMP9
18 10.74 MMP1 MMP9

GO Terms for Hypertensive Heart Disease

Cellular components related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ACE AGT CTF1 MMP1 MMP2 MMP9
2 receptor complex GO:0043235 9.33 CD36 NPR1 NR3C2
3 extracellular space GO:0005615 9.17 ACE AGT CD36 CTF1 MMP2 MMP9

Biological processes related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 AGT AGTR1 CD36
2 cytokine-mediated signaling pathway GO:0019221 9.83 CD36 CTF1 MMP1 MMP2 MMP9
3 negative regulation of cell growth GO:0030308 9.81 AGT NPPB NPR1
4 negative regulation of angiogenesis GO:0016525 9.81 AGT NPPB NPR1
5 cell surface receptor signaling pathway GO:0007166 9.8 AGT CD36 CTF1 NPPB NPR1
6 kidney development GO:0001822 9.79 ACE AGT AGTR1
7 extracellular matrix disassembly GO:0022617 9.74 MMP1 MMP2 MMP9
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.71 AGT MMP2 MMP9
9 collagen catabolic process GO:0030574 9.69 MMP1 MMP2 MMP9
10 blood vessel remodeling GO:0001974 9.67 ACE AGT
11 endodermal cell differentiation GO:0035987 9.67 MMP2 MMP9
12 cGMP-mediated signaling GO:0019934 9.66 CD36 NPR1
13 positive regulation of blood pressure GO:0045777 9.66 ACE AGT
14 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.65 AGT MMP9
15 nitric oxide mediated signal transduction GO:0007263 9.65 AGT CD36
16 positive regulation of reactive oxygen species metabolic process GO:2000379 9.65 AGT AGTR1 CD36
17 positive regulation of cellular protein metabolic process GO:0032270 9.64 AGT AGTR1
18 low-density lipoprotein particle remodeling GO:0034374 9.63 AGT AGTR1
19 regulation of vasoconstriction GO:0019229 9.63 ACE AGT AGTR1
20 positive regulation of urine volume GO:0035810 9.62 NPPB NPR1
21 cGMP biosynthetic process GO:0006182 9.61 NPPB NPR1
22 receptor guanylyl cyclase signaling pathway GO:0007168 9.61 NPPB NPR1
23 regulation of vascular permeability GO:0043114 9.6 NPPB NPR1
24 body fluid secretion GO:0007589 9.59 NPPB NPR1
25 positive regulation of cholesterol esterification GO:0010873 9.58 AGT AGTR1
26 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGT AGTR1
27 regulation of renal sodium excretion GO:0035813 9.56 AGT AGTR1
28 renin-angiotensin regulation of aldosterone production GO:0002018 9.55 AGT AGTR1
29 regulation of blood vessel size GO:0050880 9.54 AGT NPPB NPR1
30 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.52 AGT AGTR1
31 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.5 AGT AGTR1 CD36
32 regulation of renal output by angiotensin GO:0002019 9.49 ACE AGT
33 regulation of blood pressure GO:0008217 9.46 ACE AGT NPPB NPR1
34 positive regulation of renal sodium excretion GO:0035815 9.43 AGT NPPB NPR1
35 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
36 regulation of blood vessel diameter GO:0097746 8.92 ACE AGTR1 NPPB NPR1

Molecular functions related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.72 ACE MMP1 MMP2 MMP9 NR3C2
2 peptidase activity GO:0008233 9.67 ACE MMP1 MMP2 MMP9
3 metalloendopeptidase activity GO:0004222 9.43 MMP1 MMP2 MMP9
4 endopeptidase activity GO:0004175 9.33 ACE MMP1 MMP9
5 metallopeptidase activity GO:0008237 9.26 ACE MMP1 MMP2 MMP9
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Hypertensive Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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