Hypertensive Heart Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP006 MIFTS: 47	Hypertensive Heart Disease Categories: Blood diseases, Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Sources

Aliases & Classifications for Hypertensive Heart Disease

MalaCards integrated aliases for Hypertensive Heart Disease:

Name: Hypertensive Heart Disease ¹¹ ⁵³ ¹⁴ ⁷¹ ⁷⁵ ³¹ ³³

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the circulatory system

Hypertensive diseases

Hypertensive heart disease

Hypertensive heart disease with (congestive) heart failure

Hypertensive heart disease without (congestive) heart failure

ICD11: ³³

Diseases of the circulatory system

Hypertensive diseases

Hypertensive heart disease

External Ids:

Disease Ontology ¹¹ DOID:11516

ICD9CM ³⁴ 402

NCIt ⁴⁹ C157879

SNOMED-CT ⁶⁸ 155297007

ICD10 ³¹ I11 I11.0 I11.9

ICD11 ³³ 1210166201

UMLS ⁷¹ C0152105

Sources

Summaries for Hypertensive Heart Disease

Disease Ontology: ¹¹ A heart disease that is caused by high blood pressure.

MalaCards based summary: Hypertensive Heart Disease is related to cardiovascular system disease and renal artery atheroma. An important gene associated with Hypertensive Heart Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cardiac conduction and MicroRNAs in cardiomyocyte hypertrophy. The drugs Irbesartan and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include heart, cardiac myocytes and kidney, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: ⁷⁵ Hypertensive heart disease includes a number of complications of high blood pressure that affect the... more...

Sources

Related Diseases for Hypertensive Heart Disease

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)

#	Related Disease	Score	Top Affiliating Genes
1	cardiovascular system disease	30.9	REN PPARA NR3C2 NPPB NPPA EDN1
2	renal artery atheroma	30.5	REN AGTR1 ACE
3	nephrosclerosis	30.5	NR3C2 AGTR1 ACE
4	angina pectoris	30.4	TNNI3 NPPB EDN1 CRP ACE
5	atrial standstill 1	30.4	TTR NPPB EDN1
6	hypertension, diastolic	30.3	REN ACE
7	aortic valve insufficiency	30.2	TNNI3 REN NPPB CRP ACE
8	infective endocarditis	30.1	NPPB CRP ACE
9	coronary stenosis	30.1	TNNI3 NPPB CRP ACE
10	fabry disease	30.1	TNNI3 NPPB CRP AGTR1
11	arteriolosclerosis	30.1	REN CRP ACE
12	alcoholic cardiomyopathy	30.1	TTN REN NPPB ACE
13	pyelonephritis	30.0	TIMP1 CRP ACE
14	renovascular hypertension	30.0	REN NR3C2 NPPB NPPA EDN1 AGTR1
15	adult syndrome	30.0	REN PPARA CRP
16	malignant hypertension	30.0	REN NPPB NPPA AGTR1 ACE
17	sleep apnea	30.0	REN NPPB EDN1 CRP ACE
18	hypertensive retinopathy	30.0	REN NR3C2 CRP ACE
19	lipid metabolism disorder	30.0	REN PPARA EDN1 CRP CD36 ACE
20	vascular disease	30.0	TTR TIMP1 EDN1 CRP AGTR1 ACE
21	cerebrovascular disease	29.9	REN CRP AGTR1 ACE
22	atrial fibrillation	29.9	TNNI3 NR3C2 NPPB NPPA CYP11B2 CRP
23	autosomal dominant polycystic kidney disease	29.8	REN EDN1 CRP ACE
24	aortic disease	29.8	TIMP1 REN NPPB CRP ACE
25	left ventricular noncompaction	29.8	TTN TNNI3 MYH6 ACE
26	hypothyroidism	29.7	TTR REN NPPB CRP ACE
27	pulmonary hypertension	29.7	REN NPPB NPPA EDN1 CRP AGTR1
28	conn's syndrome	29.7	REN NR3C2 NPPA EDN1 CYP11B2 CRP
29	stroke, ischemic	29.7	REN NR3C2 NPPB NPPA CRP CD36
30	arteries, anomalies of	29.7	TNNI3 REN MIR208B EDN1 CRP AGTR1
31	atherosclerosis susceptibility	29.7	PPARA EDN1 CRP CD36 AGTR1 ACE
32	apnea, obstructive sleep	29.6	REN NR3C2 NPPB EDN1 CRP ACE
33	renal hypertension	29.6	REN NR3C2 EDN1 CRP AGTR1 ACE
34	aortic valve disease 2	29.6	TTR TTN TNNI3 REN NPPB NPPA
35	pericardial effusion	29.6	TTR TNNI3 REN NPPB NPPA CRP
36	mitral valve stenosis	29.5	TTR REN NR3C2 NPPB NPPA EDN1
37	atrioventricular block	29.5	TNNI3 NPPB MYH6 MMP1 CRP ACE
38	arteriosclerosis	29.5	TTR TIMP1 PPARA EDN1 CRP ACE
39	first-degree atrioventricular block	29.4	TTR TTN TNNI3 NPPB CRP ACE
40	body mass index quantitative trait locus 11	29.4	REN PPARA NR3C2 NPR1 EDN1 CRP
41	mitral valve insufficiency	29.4	TTN TNNI3 REN NR3C2 NPPB NPPA
42	congestive heart failure	29.3	TTN TNNI3 REN NR3C2 NPR1 NPPB
43	lipoprotein quantitative trait locus	29.3	TTN TNNI3 REN PPARA NPPB NPPA
44	heart disease	29.3	TTR TTN TNNI3 REN PPARA NR3C2
45	hypertrophic cardiomyopathy	29.2	TTR TTN TNNI3 REN PPARA NR3C2
46	pulmonary edema	29.2	TNNI3 REN NPPB NPPA EDN1 CRP
47	myocarditis	29.2	TTN TNNI3 NPPB NPPA MYH6 EDN1
48	aortic valve disease 1	29.2	TIMP1 REN NPPB MYH6 EDN1 CRP
49	diastolic heart failure	29.2	TTR TTN TNNI3 REN NR3C2 NPPB
50	chronic kidney disease	29.1	TTR TNNI3 REN NR3C2 NPPB NPPA

Comorbidity relations with Hypertensive Heart Disease via Phenotypic Disease Network (PDN):

Acute Cystitis	Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:

Sources

Symptoms & Phenotypes for Hypertensive Heart Disease

MGI Mouse Phenotypes related to Hypertensive Heart Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.19	ACE AGTR1 CD36 CRP CTF1 CYP11B2
2	muscle	MP:0005369	10.13	CD36 CYP11B2 EDN1 MIR208B MYH6 NPPA
3	renal/urinary system	MP:0005367	10.07	ACE AGTR1 CD36 CYP11B2 EDN1 NPPA
4	growth/size/body region	MP:0005378	9.97	ACE AGTR1 CD36 CTF1 CYP11B2 EDN1
5	cardiovascular system	MP:0005385	9.89	ACE AGTR1 CD36 CRP CYP11B2 EDN1
6	immune system	MP:0005387	9.4	ACE AGTR1 CD36 CRP CYP11B2 MMP1

Sources

Drugs & Therapeutics for Hypertensive Heart Disease

Drugs for Hypertensive Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Irbesartan

Approved, Investigational

Phase 4

138402-11-6

3749

Ramipril

Approved

Phase 4

87333-19-5

5362129

Angiotensin-Converting Enzyme Inhibitors

Phase 4

HIV Protease Inhibitors

Phase 4

protease inhibitors

Phase 4

Spironolactone

Approved

Phase 3

1952-01-7, 52-01-7

5833

diuretics

Phase 3

Hormones

Phase 3

Hormone Antagonists

Phase 3

Diuretics, Potassium Sparing

Phase 3

Mineralocorticoids

Phase 3

Mineralocorticoid Receptor Antagonists

Phase 3

Angiotensin II

Approved, Investigational

Phase 2

68521-88-0, 11128-99-7, 4474-91-3

172198

Amlodipine

Approved

Phase 2

88150-42-9

2162

Valsartan

Approved, Investigational

Phase 2

137862-53-4

60846

Hydrochlorothiazide

Approved, Vet_approved

Phase 2

58-93-5

3639

Antihypertensive Agents

Phase 2

Angiotensinogen

Phase 2

16133225

Angiotensin Receptor Antagonists

Phase 2

Angiotensin II Type 1 Receptor Blockers

Phase 2

Giapreza

Phase 2

Sacubitril and valsartan sodium hydrate drug combination

Phase 2

Grape

Approved

Phase 1

Quercetin

Experimental, Investigational

Phase 1

117-39-5

10283929 5320834 5280343

Resveratrol

Investigational

Phase 1

501-36-0

445154

Antioxidants

Phase 1

Anthocyanidin

Phase 1

Platelet Aggregation Inhibitors

Phase 1

Grape Seed Extract

Phase 1

91973920

Protective Agents

Phase 1

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

Tannic acid

Approved

1401-55-4

16129878 16129778

Atropine

Approved, Vet_approved

101-31-5, 5908-99-6, 51-55-8

3661 154417 174174

Parasympatholytics

Bronchodilator Agents

Neurotransmitter Agents

Anti-Asthmatic Agents

Anti-Arrhythmia Agents

Anesthetics

Respiratory System Agents

Mydriatics

Muscarinic Antagonists

Cholinergic Antagonists

Cholinergic Agents

Interventional clinical trials:

(show all 16)

#	Name	Status	NCT ID	Phase	Drugs
1	Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan	Unknown status	NCT00517322	Phase 4	ramipril;irbesartan
2	Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease	Completed	NCT00865501	Phase 3	spironolactone;placebo
3	Role of ARNi in Ventricular Remodeling in Hypertensive LVH	Recruiting	NCT03553810	Phase 2	Entresto;Valsartan
4	GRAPe Seed Extract and Ventriculovascular Investigation in Normal Ejection-Fraction Heart Failure	Completed	NCT01185067	Phase 1	grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
5	E_Stethoscope : Portable Digital Auscultation Based on Wireless Sensor Node to Diagnose Diastolic Dysfunction in Hypertensive Heart Disease	Unknown status	NCT02809040
6	Asian American Partnerships in Research and Empowerment (AsPIRE)	Completed	NCT03100812
7	EARLY Differentiation of MYOcardial Hypertrophy Between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy	Completed	NCT03271385
8	Renal Sympathetic Denervation Restores Autonomic Imbalance and Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study	Completed	NCT01990911		Medical therapy
9	Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet on Ventriculovascular Function in Heart Failure With Preserved Systolic Function	Completed	NCT00939640
10	The Personalized Chinese Herb Formulas Are Evaluated for Their Effectiveness to Relieve Symptoms in Hypertensive Bradyarrhythmia	Completed	NCT04505228		Safflower (Carthamus Tinctorius) IgG4 &#X7C; Serum &#X7C; Allergy;Atropine Sulfate
11	Association Between Enhanced Sympathetic Activity and Cardiometabolic Complications: a Cross-sectional Study on Predictive Power of 24-hour Urinary Metanephrines (SYMPACT)	Completed	NCT04495231
12	Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease	Completed	NCT03476785
13	Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline	Recruiting	NCT04682977
14	Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection (ACTIV4)	Recruiting	NCT05226416
15	The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study	Enrolling by invitation	NCT04190420
16	Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)	Terminated	NCT01942395

Search NIH Clinical Center for Hypertensive Heart Disease

Sources

Genetic Tests for Hypertensive Heart Disease

Sources

Anatomical Context for Hypertensive Heart Disease

Organs/tissues related to Hypertensive Heart Disease:

MalaCards : Heart, Cardiac Myocytes, Kidney, Endothelial, Bone Marrow, Brain, T Cells

Sources

Publications for Hypertensive Heart Disease

Articles related to Hypertensive Heart Disease:

(show top 50) (show all 1742)

#	Title	Authors	PMID	Year
1	Relation of circulating markers of fibrosis and progression of left and right ventricular dysfunction in hypertensive patients with heart failure. ⁵³ ⁶²	Plaksej R...Weidemann F	19887955	2009
2	Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. ⁵³ ⁶²	Huang M...He J	19117407	2009
3	Mineralocorticoid signaling in transition to heart failure with normal ejection fraction. ⁵³ ⁶²	Shapiro BP...Redfield MM	18086943	2008
4	Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. ⁵³ ⁶²	Kato M...Kitakaze M	17127817	2006
5	Measurements of baseline and follow-up concentrations of cardiac troponin-T and brain natriuretic peptide in patients with heart failure from various etiologies. ⁵³ ⁶²	Taniguchi R...Kita T	17143708	2006
6	Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease. ⁵³ ⁶²	Goikoetxea MJ...Diez J	16371224	2006
7	Comparison of positive cases for B-type natriuretic peptide and ECG testing for identification of precursor forms of heart failure in an elderly population. ⁵³ ⁶²	Nakamura M...Hiramori K	16043943	2005
8	Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. ⁵³ ⁶²	Querejeta R...Diez J	15313958	2004
9	Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. ⁵³ ⁶²	Ogata T...Yamaguchi I	15093887	2004
10	Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis. ⁵³ ⁶²	Lopez B...Diez J	15202614	2004
11	Peroxisome proliferator-activated receptor alpha and hypertensive heart disease. ⁵³ ⁶²	Goikoetxea MJ...Diez J	15765888	2004
12	The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives. ⁵³ ⁶²	Diez J...Beloqui O	14597852	2003
13	Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. ⁵³ ⁶²	Shi SJ...Pandey KN	12824076	2003
14	Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease. ⁵³ ⁶²	Dean DE...Powers RH	11569573	2001
15	Renin-angiotensin system inhibition improves coronary flow reserve in hypertension. ⁵³ ⁶²	Frohlich ED	11392478	2001
16	Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. ⁵³ ⁶²	Schwartzkopff B...Strauer BE	10948081	2000
17	AT1 receptors: coronary flow and flow reserve. ⁵³ ⁶²	Frohlich ED	10678287	2000
18	[Hypertensive heart disease with left ventricular diastolic dysfunction demonstrating restrictive hemodynamics: a case report]. ⁵³ ⁶²	Soeki T...Tamura Y	10396707	1999
19	Angiotensin converting enzyme inhibition by captopril influences cardiac work in healthy hearts. ⁵³ ⁶²	Derad I...Born J	9832171	1998
20	Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. ⁵³ ⁶²	Oliver PM...Maeda N	9405681	1997
21	Effects of moexiprilat on oestrogen-stimulated cardiac fibroblast growth. ⁵³ ⁶²	Grohe C...Neyses L	9257913	1997
22	Marked expression of plasma brain natriuretic peptide is a special feature of hypertrophic obstructive cardiomyopathy. ⁵³ ⁶²	Nishigaki K...Fujiwara H	8890821	1996
23	Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. ⁵³ ⁶²	Brilla CG...Weber KT	8518539	1993
24	Growing Heart Failure Burden of Hypertensive Heart Disease: A Call to Action. ⁶²	Diez J...Butler J	36082670	2023
25	Differential diagnosis of common etiologies of left ventricular hypertrophy using a hybrid CNN-LSTM model. ⁶²	Hwang IC...Cho GY	36470931	2022
26	Aortic stiffness and aortic-brachial stiffness mismatch as markers of renal dysfunction in hypertension. ⁶²	Lundwall K...Spaak J	35546095	2022
27	NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload. ⁶²	Higashikuni Y...Sata M	36440584	2022
28	Trends in Regional Disparity in Cardiovascular Mortality in Korea, 1983-2019. ⁶²	Kim E...Kim HC	36347519	2022
29	Intelligent diagnosis of left ventricular hypertrophy using transthoracic echocardiography videos. ⁶²	Xu Z...Zhang Q	36257197	2022
30	Pathological features of biopsied myocardium in patients clinically diagnosed with peripartum cardiomyopathy. ⁶²	Kawano H...Maemura K	36348099	2022
31	[Analysis on impact of four major non-communicable diseases on life expectancy of local population in Ji'nan, 2015-2020]. ⁶²	Zhou L...Ruan SM	36444454	2022
32	Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy. ⁶²	Han C...Xia C	36070120	2022
33	Hypertensive heart disease and myocardial fibrosis: How traditional Chinese medicine can help addressing unmet therapeutical needs. ⁶²	Liu M...Zhou H	36265555	2022
34	Peripartum Cardiomyopathy. ⁶²	Shrikhande L...Shrikhande B	36458061	2022
35	Phenotyping the hypertensive heart. ⁶²	Tadic M...Marwick TH	35869979	2022
36	Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure. ⁶²	Brandt M...Wenzel P	35862118	2022
37	Hypertension and its complications are also common in low-resource specialty clinics. ⁶²	Adamu UG...Ibok IO	36243762	2022
38	Left Atrial Myocardium in Arterial Hypertension. ⁶²	Kockskamper J...Pluteanu F	36231118	2022
39	Right Ventricle in Arterial Hypertension: Did We Forget Something? ⁶²	Tadic M...Cuspidi C	36362485	2022
40	Temporal trends in the burden of non-communicable diseases in countries with the highest malaria burden, 1990-2019: Evaluating the double burden of non-communicable and communicable diseases in epidemiological transition. ⁶²	Li Z...Zheng ZJ	36274138	2022
41	Estimating the changing burden of disease attributable to high sodium intake in South Africa for 2000, 2006 and 2012. ⁶²	Nojilana B...Bradshaw D	36458360	2022
42	Estimating the changing burden of disease attributable to high systolic blood pressure in South Africa for 2000, 2006 and 2012. ⁶²	Nojilana B...Bradshaw D	36458347	2022
43	Is it necessary to perform cardiovascular screening in migrant patients? ⁶²	Roa-Chamorro R...Torres-Quintero L	35840428	2022
44	Low coronary flow relative to myocardial mass predicts heart failure in symptomatic hypertensive patients with no obstructive coronary artery disease. ⁶²	Brown JM...Di Carli MF	34491335	2022
45	Estimating the changing burden of disease attributable to high body mass index in South Africa for 2000, 2006 and 2012. ⁶²	Bradshaw D...Pillay van-Wyk V	36458354	2022
46	Multimodal imaging shows fibrosis architecture and action potential dispersion are predictors of arrhythmic risk in spontaneous hypertensive rats. ⁶²	Khwaounjoo P...Trew ML	35984854	2022
47	Effects of high-absorption curcumin for the prevention of hypertensive heart disease: a double-blind, placebo-controlled, randomized clinical study. ⁶²	Funamoto M...Hasegawa K	36172003	2022
48	Special Issue: Hypertensive Heart Disease-From Pathophysiology to Therapeutical Challenges. ⁶²	Vischer AS...Burkard T	36012879	2022
49	Inverse salt sensitivity: an independent risk factor for cardiovascular damage in essential hypertension. ⁶²	Cuka E...Manunta P	35881450	2022
50	Genetic Deletion of Galectin-3 Exacerbates Age-Related Myocardial Hypertrophy and Fibrosis in Mice. ⁶²	Fontana Estevez FS...Gonzalez GE	35959709	2022

Sources

Genes for Hypertensive Heart Disease

Genes related to Hypertensive Heart Disease (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ACE	Angiotensin I Converting Enzyme	Protein Coding	22.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19117407 11569573 8518539 (more) 9832171 9257913 10948081 15093864 11392478
2	NPPB	Natriuretic Peptide B	Protein Coding	21.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17143708 16043943 17127817 (more) 10396707
3	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	18.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10678287
4	CD36	CD36 Molecule	Protein Coding	17.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15313958 14597852 19887955
5	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	11.99	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	11.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9405681 12824076
7	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	10.38	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18086943
8	NPPA	Natriuretic Peptide A	Protein Coding	10.03	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8890821 10396707
9	MMP1	Matrix Metallopeptidase 1	Protein Coding	9.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15202614
10	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	7.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15765888 15093887 16371224
11	REN	Renin	Protein Coding	7.2	DISEASES inferred ¹⁴
12	MIR208B	MicroRNA 208b	RNA Gene	6.84	DISEASES inferred ¹⁴ ¹⁴
13	CTF1	Cardiotrophin 1	Protein Coding	6.32	DISEASES inferred ¹⁴
14	TTR	Transthyretin	Protein Coding	6.3	DISEASES inferred ¹⁴
15	EDN1	Endothelin 1	Protein Coding	5.9	DISEASES inferred ¹⁴
16	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	5.87	DISEASES inferred ¹⁴
17	TTN	Titin	Protein Coding	5.83	DISEASES inferred ¹⁴
18	MYH6	Myosin Heavy Chain 6	Protein Coding	5.63	DISEASES inferred ¹⁴
19	TNNI3	Troponin I3, Cardiac Type	Protein Coding	5.6	DISEASES inferred ¹⁴
20	CRP	C-Reactive Protein	Protein Coding	5.58	DISEASES inferred ¹⁴
21	CCN2	Cellular Communication Network Factor 2	Protein Coding	5.56	DISEASES inferred ¹⁴
22	IL6	Interleukin 6	Protein Coding	5.54	DISEASES inferred ¹⁴
23	INS	Insulin	Protein Coding	5.49	DISEASES inferred ¹⁴
24	TNNT2	Troponin T2, Cardiac Type	Protein Coding	5.45	DISEASES inferred ¹⁴
25	MYH7	Myosin Heavy Chain 7	Protein Coding	5.28	DISEASES inferred ¹⁴

Sources

Variations for Hypertensive Heart Disease

Sources

Expression for Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Sources

Pathways for Hypertensive Heart Disease

Pathways related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cardiac conduction ⁶⁶ Show member pathways Classical Kir channels ⁶⁶ Ion homeostasis ⁶⁶ Ion transport by P-type ATPases ⁶⁶ Muscle contraction ⁶⁶ Phase 1 - inactivation of fast Na+ channels ⁶⁶ Phase 2 - plateau phase ⁶⁶ Phase 3 - rapid repolarisation ⁶⁶ Phase 4 - resting membrane potential ⁶⁶ Physiological factors ⁶⁶ Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) ⁶⁶ Tandem pore domain halothane-inhibited K+ channel (THIK) ⁶⁶ Tandem pore domain potassium channels ⁶⁶ TWIK related potassium channel (TREK) ⁶⁶ TWIK-related alkaline pH activated K+ channel (TALK) ⁶⁶ TWIK-related spinal cord K+ channel (TRESK) ⁶⁶ TWIK-releated acid-sensitive K+ channel (TASK) ⁶⁶	12.56	TTN TNNI3 NPR1 NPPA MYH6
2	MicroRNAs in cardiomyocyte hypertrophy ⁷⁴ Show member pathways Cardiac hypertrophic response ⁷⁴	11.73	NPPB NPPA EDN1 CTF1
3	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.69	TIMP1 MMP1 CD36
4	PPAR signaling pathway ⁷⁴ Show member pathways FABP4 in ovarian cancer ⁷⁴ Fatty acid transporters ⁷⁴	11.57	PPARA MMP1 CD36
5	Striated muscle contraction pathway ⁷⁴ Show member pathways Striated Muscle Contraction ⁶⁶	11.45	TTN TNNI3 MYH6
6	Interleukin-6 family signaling ⁶⁶ Show member pathways IL-6-type cytokine receptor ligand interactions ⁶⁶ Immune response Oncostatin M signaling via JAK-Stat in human cells ²² Interleukin-6 signaling ⁶⁶	11.4	TIMP1 MMP1 CTF1
7	NO/cGMP/PKG mediated neuroprotection ⁷⁴	11.14	NPR1 NPPB NPPA
8	AP-1 transcription factor network ⁶¹	11.1	TIMP1 NPPA MMP1 EDN1
9	ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE inhibitor pathway ⁷⁴ Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Conversion of angiotensinogen to angiotensin II ⁷⁴ Defective SERPING1 causes hereditary angioedema ⁶⁶ Downregulation of ACE2 by SARS-CoV-2 spike protein ⁷⁴ Kinin-Kallikrein pathway ⁷⁴ Non-classical role of vitamin D ⁷⁴ RAS and bradykinin pathways in COVID-19 ⁷⁴ Renin-angiotensin-aldosterone system (RAAS) ⁷⁴ SARS-CoV-2 and ACE2 receptor: molecular mechanisms ⁷⁴	11.08	REN NR3C2 CYP11B2 AGTR1 ACE
10	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.81	TIMP1 EDN1 CRP

Sources

GO Terms for Hypertensive Heart Disease

Cellular components related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.96	TTR TIMP1 REN NPPB NPPA EDN1
2	extracellular region	GO:0005576	9.66	ACE CRP CTF1 EDN1 MMP1 NPPA

Biological processes related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	10.25	NPR1 NPPB EDN1 CTF1 CD36
2	cardiac muscle contraction	GO:0060048	10.01	TTN TNNI3 MYH6
3	regulation of vasoconstriction	GO:0019229	9.97	EDN1 AGTR1 ACE
4	vasoconstriction	GO:0042310	9.95	EDN1 CRP ACE
5	positive regulation of urine volume	GO:0035810	9.91	EDN1 NPPB NPR1
6	positive regulation of renal sodium excretion	GO:0035815	9.88	EDN1 NPPB NPR1
7	striated muscle contraction	GO:0006941	9.85	TTN TNNI3 MYH6
8	cGMP biosynthetic process	GO:0006182	9.85	NPR1 NPPB NPPA
9	regulation of systemic arterial blood pressure by renin-angiotensin	GO:0003081	9.83	AGTR1 ACE
10	renin-angiotensin regulation of aldosterone production	GO:0002018	9.81	AGTR1 REN
11	receptor guanylyl cyclase signaling pathway	GO:0007168	9.8	NPR1 NPPB NPPA
12	regulation of blood pressure	GO:0008217	9.77	REN NPR1 NPPB NPPA MYH6 EDN1
13	cGMP-mediated signaling	GO:0019934	9.76	CD36 NPPA NPPB NPR1
14	body fluid secretion	GO:0007589	9.73	NPR1 NPPB EDN1
15	blood vessel diameter maintenance	GO:0097746	9.32	NPR1 NPPB NPPA EDN1 AGTR1 ACE