MCID: HYP006
MIFTS: 47

Hypertensive Heart Disease

Categories: Blood diseases, Cardiovascular diseases
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Aliases & Classifications for Hypertensive Heart Disease

Summaries for Hypertensive Heart Disease

Disease Ontology: 11 A heart disease that is caused by high blood pressure.

MalaCards based summary: Hypertensive Heart Disease is related to cardiovascular system disease and renal artery atheroma. An important gene associated with Hypertensive Heart Disease is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Cardiac conduction and MicroRNAs in cardiomyocyte hypertrophy. The drugs Irbesartan and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include heart, cardiac myocytes and kidney, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: 75 Hypertensive heart disease includes a number of complications of high blood pressure that affect the... more...

Related Diseases for Hypertensive Heart Disease

Diseases related to Hypertensive Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 cardiovascular system disease 30.9 REN PPARA NR3C2 NPPB NPPA EDN1
2 renal artery atheroma 30.5 REN AGTR1 ACE
3 nephrosclerosis 30.5 NR3C2 AGTR1 ACE
4 angina pectoris 30.4 TNNI3 NPPB EDN1 CRP ACE
5 atrial standstill 1 30.4 TTR NPPB EDN1
6 hypertension, diastolic 30.3 REN ACE
7 aortic valve insufficiency 30.2 TNNI3 REN NPPB CRP ACE
8 infective endocarditis 30.1 NPPB CRP ACE
9 coronary stenosis 30.1 TNNI3 NPPB CRP ACE
10 fabry disease 30.1 TNNI3 NPPB CRP AGTR1
11 arteriolosclerosis 30.1 REN CRP ACE
12 alcoholic cardiomyopathy 30.1 TTN REN NPPB ACE
13 pyelonephritis 30.0 TIMP1 CRP ACE
14 renovascular hypertension 30.0 REN NR3C2 NPPB NPPA EDN1 AGTR1
15 adult syndrome 30.0 REN PPARA CRP
16 malignant hypertension 30.0 REN NPPB NPPA AGTR1 ACE
17 sleep apnea 30.0 REN NPPB EDN1 CRP ACE
18 hypertensive retinopathy 30.0 REN NR3C2 CRP ACE
19 lipid metabolism disorder 30.0 REN PPARA EDN1 CRP CD36 ACE
20 vascular disease 30.0 TTR TIMP1 EDN1 CRP AGTR1 ACE
21 cerebrovascular disease 29.9 REN CRP AGTR1 ACE
22 atrial fibrillation 29.9 TNNI3 NR3C2 NPPB NPPA CYP11B2 CRP
23 autosomal dominant polycystic kidney disease 29.8 REN EDN1 CRP ACE
24 aortic disease 29.8 TIMP1 REN NPPB CRP ACE
25 left ventricular noncompaction 29.8 TTN TNNI3 MYH6 ACE
26 hypothyroidism 29.7 TTR REN NPPB CRP ACE
27 pulmonary hypertension 29.7 REN NPPB NPPA EDN1 CRP AGTR1
28 conn's syndrome 29.7 REN NR3C2 NPPA EDN1 CYP11B2 CRP
29 stroke, ischemic 29.7 REN NR3C2 NPPB NPPA CRP CD36
30 arteries, anomalies of 29.7 TNNI3 REN MIR208B EDN1 CRP AGTR1
31 atherosclerosis susceptibility 29.7 PPARA EDN1 CRP CD36 AGTR1 ACE
32 apnea, obstructive sleep 29.6 REN NR3C2 NPPB EDN1 CRP ACE
33 renal hypertension 29.6 REN NR3C2 EDN1 CRP AGTR1 ACE
34 aortic valve disease 2 29.6 TTR TTN TNNI3 REN NPPB NPPA
35 pericardial effusion 29.6 TTR TNNI3 REN NPPB NPPA CRP
36 mitral valve stenosis 29.5 TTR REN NR3C2 NPPB NPPA EDN1
37 atrioventricular block 29.5 TNNI3 NPPB MYH6 MMP1 CRP ACE
38 arteriosclerosis 29.5 TTR TIMP1 PPARA EDN1 CRP ACE
39 first-degree atrioventricular block 29.4 TTR TTN TNNI3 NPPB CRP ACE
40 body mass index quantitative trait locus 11 29.4 REN PPARA NR3C2 NPR1 EDN1 CRP
41 mitral valve insufficiency 29.4 TTN TNNI3 REN NR3C2 NPPB NPPA
42 congestive heart failure 29.3 TTN TNNI3 REN NR3C2 NPR1 NPPB
43 lipoprotein quantitative trait locus 29.3 TTN TNNI3 REN PPARA NPPB NPPA
44 heart disease 29.3 TTR TTN TNNI3 REN PPARA NR3C2
45 hypertrophic cardiomyopathy 29.2 TTR TTN TNNI3 REN PPARA NR3C2
46 pulmonary edema 29.2 TNNI3 REN NPPB NPPA EDN1 CRP
47 myocarditis 29.2 TTN TNNI3 NPPB NPPA MYH6 EDN1
48 aortic valve disease 1 29.2 TIMP1 REN NPPB MYH6 EDN1 CRP
49 diastolic heart failure 29.2 TTR TTN TNNI3 REN NR3C2 NPPB
50 chronic kidney disease 29.1 TTR TNNI3 REN NR3C2 NPPB NPPA

Comorbidity relations with Hypertensive Heart Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Hypertensive Heart Disease:



Diseases related to Hypertensive Heart Disease

Symptoms & Phenotypes for Hypertensive Heart Disease

MGI Mouse Phenotypes related to Hypertensive Heart Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.19 ACE AGTR1 CD36 CRP CTF1 CYP11B2
2 muscle MP:0005369 10.13 CD36 CYP11B2 EDN1 MIR208B MYH6 NPPA
3 renal/urinary system MP:0005367 10.07 ACE AGTR1 CD36 CYP11B2 EDN1 NPPA
4 growth/size/body region MP:0005378 9.97 ACE AGTR1 CD36 CTF1 CYP11B2 EDN1
5 cardiovascular system MP:0005385 9.89 ACE AGTR1 CD36 CRP CYP11B2 EDN1
6 immune system MP:0005387 9.4 ACE AGTR1 CD36 CRP CYP11B2 MMP1

Drugs & Therapeutics for Hypertensive Heart Disease

Drugs for Hypertensive Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
2
Ramipril Approved Phase 4 87333-19-5 5362129
3 Angiotensin-Converting Enzyme Inhibitors Phase 4
4 HIV Protease Inhibitors Phase 4
5
protease inhibitors Phase 4
6
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
7 diuretics Phase 3
8 Hormones Phase 3
9 Hormone Antagonists Phase 3
10 Diuretics, Potassium Sparing Phase 3
11 Mineralocorticoids Phase 3
12 Mineralocorticoid Receptor Antagonists Phase 3
13
Angiotensin II Approved, Investigational Phase 2 68521-88-0, 11128-99-7, 4474-91-3 172198
14
Amlodipine Approved Phase 2 88150-42-9 2162
15
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
16
Hydrochlorothiazide Approved, Vet_approved Phase 2 58-93-5 3639
17 Antihypertensive Agents Phase 2
18
Angiotensinogen Phase 2 16133225
19 Angiotensin Receptor Antagonists Phase 2
20 Angiotensin II Type 1 Receptor Blockers Phase 2
21 Giapreza Phase 2
22 Sacubitril and valsartan sodium hydrate drug combination Phase 2
23 Grape Approved Phase 1
24
Quercetin Experimental, Investigational Phase 1 117-39-5 10283929 5320834 5280343
25
Resveratrol Investigational Phase 1 501-36-0 445154
26 Antioxidants Phase 1
27 Anthocyanidin Phase 1
28 Platelet Aggregation Inhibitors Phase 1
29
Grape Seed Extract Phase 1 91973920
30 Protective Agents Phase 1
31
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
32
Tannic acid Approved 1401-55-4 16129878 16129778
33
Atropine Approved, Vet_approved 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
34 Parasympatholytics
35 Bronchodilator Agents
36 Neurotransmitter Agents
37 Anti-Asthmatic Agents
38 Anti-Arrhythmia Agents
39 Anesthetics
40 Respiratory System Agents
41 Mydriatics
42 Muscarinic Antagonists
43 Cholinergic Antagonists
44 Cholinergic Agents

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan Unknown status NCT00517322 Phase 4 ramipril;irbesartan
2 Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease Completed NCT00865501 Phase 3 spironolactone;placebo
3 Role of ARNi in Ventricular Remodeling in Hypertensive LVH Recruiting NCT03553810 Phase 2 Entresto;Valsartan
4 GRAPe Seed Extract and Ventriculovascular Investigation in Normal Ejection-Fraction Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
5 E_Stethoscope : Portable Digital Auscultation Based on Wireless Sensor Node to Diagnose Diastolic Dysfunction in Hypertensive Heart Disease Unknown status NCT02809040
6 Asian American Partnerships in Research and Empowerment (AsPIRE) Completed NCT03100812
7 EARLY Differentiation of MYOcardial Hypertrophy Between Hypertensive Heart Disease and Hypertrophic Cardiomyopathy Completed NCT03271385
8 Renal Sympathetic Denervation Restores Autonomic Imbalance and Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study Completed NCT01990911 Medical therapy
9 Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet on Ventriculovascular Function in Heart Failure With Preserved Systolic Function Completed NCT00939640
10 The Personalized Chinese Herb Formulas Are Evaluated for Their Effectiveness to Relieve Symptoms in Hypertensive Bradyarrhythmia Completed NCT04505228 Safflower (Carthamus Tinctorius) IgG4 | Serum | Allergy;Atropine Sulfate
11 Association Between Enhanced Sympathetic Activity and Cardiometabolic Complications: a Cross-sectional Study on Predictive Power of 24-hour Urinary Metanephrines (SYMPACT) Completed NCT04495231
12 Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease Completed NCT03476785
13 Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline Recruiting NCT04682977
14 Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection (ACTIV4) Recruiting NCT05226416
15 The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study Enrolling by invitation NCT04190420
16 Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2) Terminated NCT01942395

Search NIH Clinical Center for Hypertensive Heart Disease

Genetic Tests for Hypertensive Heart Disease

Anatomical Context for Hypertensive Heart Disease

Organs/tissues related to Hypertensive Heart Disease:

MalaCards : Heart, Cardiac Myocytes, Kidney, Endothelial, Bone Marrow, Brain, T Cells

Publications for Hypertensive Heart Disease

Articles related to Hypertensive Heart Disease:

(show top 50) (show all 1742)
# Title Authors PMID Year
1
Relation of circulating markers of fibrosis and progression of left and right ventricular dysfunction in hypertensive patients with heart failure. 53 62
19887955 2009
2
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease. 53 62
19117407 2009
3
Mineralocorticoid signaling in transition to heart failure with normal ejection fraction. 53 62
18086943 2008
4
Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. 53 62
17127817 2006
5
Measurements of baseline and follow-up concentrations of cardiac troponin-T and brain natriuretic peptide in patients with heart failure from various etiologies. 53 62
17143708 2006
6
Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease. 53 62
16371224 2006
7
Comparison of positive cases for B-type natriuretic peptide and ECG testing for identification of precursor forms of heart failure in an elderly population. 53 62
16043943 2005
8
Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. 53 62
15313958 2004
9
Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. 53 62
15093887 2004
10
Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis. 53 62
15202614 2004
11
Peroxisome proliferator-activated receptor alpha and hypertensive heart disease. 53 62
15765888 2004
12
The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives. 53 62
14597852 2003
13
Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. 53 62
12824076 2003
14
Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease. 53 62
11569573 2001
15
Renin-angiotensin system inhibition improves coronary flow reserve in hypertension. 53 62
11392478 2001
16
Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. 53 62
10948081 2000
17
AT1 receptors: coronary flow and flow reserve. 53 62
10678287 2000
18
[Hypertensive heart disease with left ventricular diastolic dysfunction demonstrating restrictive hemodynamics: a case report]. 53 62
10396707 1999
19
Angiotensin converting enzyme inhibition by captopril influences cardiac work in healthy hearts. 53 62
9832171 1998
20
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. 53 62
9405681 1997
21
Effects of moexiprilat on oestrogen-stimulated cardiac fibroblast growth. 53 62
9257913 1997
22
Marked expression of plasma brain natriuretic peptide is a special feature of hypertrophic obstructive cardiomyopathy. 53 62
8890821 1996
23
Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation. 53 62
8518539 1993
24
Growing Heart Failure Burden of Hypertensive Heart Disease: A Call to Action. 62
36082670 2023
25
Differential diagnosis of common etiologies of left ventricular hypertrophy using a hybrid CNN-LSTM model. 62
36470931 2022
26
Aortic stiffness and aortic-brachial stiffness mismatch as markers of renal dysfunction in hypertension. 62
35546095 2022
27
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload. 62
36440584 2022
28
Trends in Regional Disparity in Cardiovascular Mortality in Korea, 1983-2019. 62
36347519 2022
29
Intelligent diagnosis of left ventricular hypertrophy using transthoracic echocardiography videos. 62
36257197 2022
30
Pathological features of biopsied myocardium in patients clinically diagnosed with peripartum cardiomyopathy. 62
36348099 2022
31
[Analysis on impact of four major non-communicable diseases on life expectancy of local population in Ji'nan, 2015-2020]. 62
36444454 2022
32
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy. 62
36070120 2022
33
Hypertensive heart disease and myocardial fibrosis: How traditional Chinese medicine can help addressing unmet therapeutical needs. 62
36265555 2022
34
Peripartum Cardiomyopathy. 62
36458061 2022
35
Phenotyping the hypertensive heart. 62
35869979 2022
36
Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure. 62
35862118 2022
37
Hypertension and its complications are also common in low-resource specialty clinics. 62
36243762 2022
38
Left Atrial Myocardium in Arterial Hypertension. 62
36231118 2022
39
Right Ventricle in Arterial Hypertension: Did We Forget Something? 62
36362485 2022
40
Temporal trends in the burden of non-communicable diseases in countries with the highest malaria burden, 1990-2019: Evaluating the double burden of non-communicable and communicable diseases in epidemiological transition. 62
36274138 2022
41
Estimating the changing burden of disease attributable to high sodium intake in South Africa for 2000, 2006 and 2012. 62
36458360 2022
42
Estimating the changing burden of disease attributable to high systolic blood pressure in South Africa for 2000, 2006 and 2012. 62
36458347 2022
43
Is it necessary to perform cardiovascular screening in migrant patients? 62
35840428 2022
44
Low coronary flow relative to myocardial mass predicts heart failure in symptomatic hypertensive patients with no obstructive coronary artery disease. 62
34491335 2022
45
Estimating the changing burden of disease attributable to high body mass index in South Africa for 2000, 2006 and 2012. 62
36458354 2022
46
Multimodal imaging shows fibrosis architecture and action potential dispersion are predictors of arrhythmic risk in spontaneous hypertensive rats. 62
35984854 2022
47
Effects of high-absorption curcumin for the prevention of hypertensive heart disease: a double-blind, placebo-controlled, randomized clinical study. 62
36172003 2022
48
Special Issue: Hypertensive Heart Disease-From Pathophysiology to Therapeutical Challenges. 62
36012879 2022
49
Inverse salt sensitivity: an independent risk factor for cardiovascular damage in essential hypertension. 62
35881450 2022
50
Genetic Deletion of Galectin-3 Exacerbates Age-Related Myocardial Hypertrophy and Fibrosis in Mice. 62
35959709 2022

Variations for Hypertensive Heart Disease

Expression for Hypertensive Heart Disease

Search GEO for disease gene expression data for Hypertensive Heart Disease.

Pathways for Hypertensive Heart Disease

Pathways related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 TTN TNNI3 NPR1 NPPA MYH6
2
Show member pathways
11.73 NPPB NPPA EDN1 CTF1
3 11.69 TIMP1 MMP1 CD36
4
Show member pathways
11.57 PPARA MMP1 CD36
5
Show member pathways
11.45 TTN TNNI3 MYH6
6
Show member pathways
11.4 TIMP1 MMP1 CTF1
7 11.14 NPR1 NPPB NPPA
8 11.1 TIMP1 NPPA MMP1 EDN1
9
Show member pathways
11.08 REN NR3C2 CYP11B2 AGTR1 ACE
10
Show member pathways
10.81 TIMP1 EDN1 CRP

GO Terms for Hypertensive Heart Disease

Cellular components related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 TTR TIMP1 REN NPPB NPPA EDN1
2 extracellular region GO:0005576 9.66 ACE CRP CTF1 EDN1 MMP1 NPPA

Biological processes related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 10.25 NPR1 NPPB EDN1 CTF1 CD36
2 cardiac muscle contraction GO:0060048 10.01 TTN TNNI3 MYH6
3 regulation of vasoconstriction GO:0019229 9.97 EDN1 AGTR1 ACE
4 vasoconstriction GO:0042310 9.95 EDN1 CRP ACE
5 positive regulation of urine volume GO:0035810 9.91 EDN1 NPPB NPR1
6 positive regulation of renal sodium excretion GO:0035815 9.88 EDN1 NPPB NPR1
7 striated muscle contraction GO:0006941 9.85 TTN TNNI3 MYH6
8 cGMP biosynthetic process GO:0006182 9.85 NPR1 NPPB NPPA
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.83 AGTR1 ACE
10 renin-angiotensin regulation of aldosterone production GO:0002018 9.81 AGTR1 REN
11 receptor guanylyl cyclase signaling pathway GO:0007168 9.8 NPR1 NPPB NPPA
12 regulation of blood pressure GO:0008217 9.77 REN NPR1 NPPB NPPA MYH6 EDN1
13 cGMP-mediated signaling GO:0019934 9.76 CD36 NPPA NPPB NPR1
14 body fluid secretion GO:0007589 9.73 NPR1 NPPB EDN1
15 blood vessel diameter maintenance GO:0097746 9.32 NPR1 NPPB NPPA EDN1 AGTR1 ACE

Molecular functions related to Hypertensive Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.56 TTR NPPB NPPA EDN1
2 hormone receptor binding GO:0051427 9.46 NPPB NPPA
3 bradykinin receptor binding GO:0031711 8.92 AGTR1 ACE

Sources for Hypertensive Heart Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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