HNP1
MCID: HYP114
MIFTS: 37

Hypertensive Nephropathy (HNP1)

Categories: Nephrological diseases

Aliases & Classifications for Hypertensive Nephropathy

MalaCards integrated aliases for Hypertensive Nephropathy:

Name: Hypertensive Nephropathy 58 13 74
Nephropathy Hypertensive 56
Hnp1 58

Classifications:



External Ids:

OMIM 58 608026
MedGen 43 C0848548
UMLS 74 C0848548

Summaries for Hypertensive Nephropathy

MalaCards based summary : Hypertensive Nephropathy, also known as nephropathy hypertensive, is related to microvascular complications of diabetes 3 and chronic kidney failure. An important gene associated with Hypertensive Nephropathy is HNP1 (Hypertensive Nephropathy), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Constitutive Androstane Receptor Pathway. The drugs Ramipril and Diltiazem have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and neutrophil.

Description from OMIM: 608026

Related Diseases for Hypertensive Nephropathy

Diseases related to Hypertensive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 29.9 ACE AGTR1 ALB
2 chronic kidney failure 29.9 ACE AGTR1 ALB
3 kidney disease 29.8 ACE AGTR1 ALB AMBP NAGLU
4 vesicoureteral reflux 1 29.6 AGTR1 AMBP NAGLU
5 iga glomerulonephritis 29.5 ACE AGTR1 ALB NAGLU
6 diabetes mellitus 28.6 ACE AGTR1 ALB MIR26B VEGFA
7 renal failure, progressive, with hypertension 11.7
8 allain-babin-demarquez syndrome 11.2
9 acute kidney tubular necrosis 10.3 ALB NAGLU
10 drug allergy 10.3 ALB CYP3A4
11 severe nonproliferative diabetic retinopathy 10.3 ALB VEGFA
12 lipoid nephrosis 10.3 ALB NAGLU
13 acroosteolysis 10.3 ALB VEGFA
14 acute pyelonephritis 10.3 ALB NAGLU
15 background diabetic retinopathy 10.3 ALB VEGFA
16 loeffler syndrome 10.2 ACE ALB
17 gastric lymphoma 10.2 ALB VEGFA
18 orthostatic proteinuria 10.2 ACE ALB
19 syndrome of inappropriate antidiuretic hormone 10.2 ACE ALB
20 renal artery disease 10.2 ACE AGTR1
21 posterior urethral valves 10.2 ACE AGTR1
22 generalized atherosclerosis 10.2 ACE CYP4A11
23 hydrops, lactic acidosis, and sideroblastic anemia 10.2 ALB VEGFA
24 aortic coarctation 10.2 ACE AGTR1
25 malignant hypertension 10.2 ACE AGTR1
26 hepatorenal syndrome 10.2 ACE ALB
27 ischemic heart disease 10.2 ACE AGTR1
28 diastolic heart failure 10.2 ACE AGTR1
29 fibromuscular dysplasia 10.2 ACE AGTR1
30 renal tubular dysgenesis 10.1 ACE AGTR1
31 oral squamous cell carcinoma 10.1
32 squamous cell carcinoma 10.1
33 portal hypertension 10.1 AGTR1 ALB VEGFA
34 renovascular hypertension 10.1 ACE AGTR1
35 neuroretinitis 10.1 ACE VEGFA
36 xanthinuria, type i 10.1 AMBP NAGLU
37 pyelonephritis 10.1 ACE ALB NAGLU
38 anuria 10.1 ACE AGTR1 ALB
39 renal hypertension 10.1 ACE AGTR1 ALB
40 nephrosclerosis 10.1 ACE AGTR1
41 vein disease 10.1 ALB VEGFA
42 end stage renal failure 10.1 ACE AGTR1 ALB
43 retinal artery occlusion 10.1 ACE VEGFA
44 nephrolithiasis, calcium oxalate 10.0 AMBP NAGLU
45 hepatitis e 10.0 ALB AMBP
46 intermittent claudication 10.0 ACE ALB VEGFA
47 retinal vascular disease 10.0 ACE ALB VEGFA
48 peripheral vascular disease 10.0 ACE ALB VEGFA
49 ischemic optic neuropathy 10.0 ACE AGTR1
50 acute mountain sickness 10.0 ACE AGTR1 VEGFA

Graphical network of the top 20 diseases related to Hypertensive Nephropathy:



Diseases related to Hypertensive Nephropathy

Symptoms & Phenotypes for Hypertensive Nephropathy

Clinical features from OMIM:

608026

Drugs & Therapeutics for Hypertensive Nephropathy

Drugs for Hypertensive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 2, Phase 3 87333-19-5 5362129
2
Diltiazem Approved, Investigational Phase 2, Phase 3 42399-41-7 39186
3
Hydralazine Approved Phase 2, Phase 3 86-54-4 3637
4 Antihypertensive Agents Phase 2, Phase 3
5
Lovastatin Approved, Investigational 75330-75-5 53232
6
Pravastatin Approved 81093-37-0 54687
7
Simvastatin Approved 79902-63-9 54454
8
Atorvastatin Approved 134523-00-5 60823
9
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
10
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
11
Testosterone Approved, Experimental, Investigational Not Applicable 58-22-0, 481-30-1 10204 6013
12
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
13
Calcium Approved, Nutraceutical 7440-70-2 271
14 Antimetabolites
15 Dihydromevinolin
16 Hydroxymethylglutaryl-CoA Reductase Inhibitors
17 L 647318
18 Calcium, Dietary
19 Anticholesteremic Agents
20 Rosuvastatin Calcium 147098-20-2
21 Lipid Regulating Agents
22 Hypolipidemic Agents
23 Hydrocortisone hemisuccinate Not Applicable
24 Hormones Not Applicable
25 Hydrocortisone 17-butyrate 21-propionate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 African American Study of Kidney Disease and Hypertension ABPM Pilot Study Completed NCT00582777 Phase 2, Phase 3 ADD On Dosing
2 Ayurvedic Management of Chronic Kidney Disease Unknown status NCT02477163
3 Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy Terminated NCT01881035 Not Applicable
4 KNOW-CKD Cohort, Phase II Study Not yet recruiting NCT03929900
5 KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease Active, not recruiting NCT01630486
6 Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML) Recruiting NCT03280888
7 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
8 Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population Recruiting NCT02316522
9 Chongqing Primary Aldosteronism Study Active, not recruiting NCT03224312
10 The Application of Microcurrent in Athletes Completed NCT03477747 Not Applicable

Search NIH Clinical Center for Hypertensive Nephropathy

Genetic Tests for Hypertensive Nephropathy

Anatomical Context for Hypertensive Nephropathy

MalaCards organs/tissues related to Hypertensive Nephropathy:

42
Kidney, Heart, Neutrophil, Monocytes, Liver, Endothelial, Smooth Muscle

Publications for Hypertensive Nephropathy

Articles related to Hypertensive Nephropathy:

(show top 50) (show all 94)
# Title Authors Year
1
MiR-101a ameliorates AngII-mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF-κB signalling in a mouse model of hypertension. ( 30304543 )
2019
2
Prediction of Drug Positioning for Quan-Du-Zhong Capsules Against Hypertensive Nephropathy Based on the Robustness of Disease Network. ( 30809144 )
2019
3
Comparison of serum levels of Cystatin-C and traditional renal biomarkers for the early detection of pre-hypertensive nephropathy. ( 30890820 )
2019
4
The predictive value of β2-MG and TGF-β for elderly hypertensive nephropathy. ( 30906478 )
2019
5
FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy. ( 31040292 )
2019
6
Bioinformatic analysis reveals novel hub genes and pathways associated with hypertensive nephropathy. ( 30298691 )
2018
7
Patients with Hypertensive Nephropathy and Chronic Kidney Disease Might Not Benefit from Strict Blood Pressure Control. ( 30472714 )
2018
8
Combined Therapy of Hypertensive Nephropathy with Breviscapine Injection and Antihypertensive Drugs: A Systematic Review and a Meta-Analysis. ( 30671127 )
2018
9
Secretion expression of human neutrophil peptide 1 (HNP1) in Pichia pastoris and its functional analysis against antibiotic-resistant Helicobacter pylori. ( 29675800 )
2018
10
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms. ( 27782909 )
2017
11
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy. ( 28244896 )
2017
12
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis. ( 28713898 )
2017
13
Interstitial complement C3 activation and macrophage infiltration in patients with hypertensive nephropathy
. ( 28793954 )
2017
14
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. ( 28808068 )
2017
15
The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients. ( 28204842 )
2017
16
Live Leishmania tarentolae secreting HNP1 as an immunotherapeutic tool against Leishmania infection in BALB/c mice. ( 29032739 )
2017
17
Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats. ( 26823279 )
2016
18
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. ( 27255359 )
2016
19
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. ( 27558173 )
2016
20
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile. ( 27756246 )
2016
21
An Analysis of Anthropometric Indicators and Modifiable Lifestyle Parameters Associated with Hypertensive Nephropathy. ( 27774313 )
2016
22
Elevated Plasma α-Defensins (HNP1-3) Levels Correlated with IgA1 Glycosylation and Susceptibility to IgA Nephropathy. ( 27563166 )
2016
23
Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). ( 26871718 )
2016
24
Alarmin human α defensin HNP1 activates plasmacytoid dendritic cells by triggering NF-κB and IRF1 signaling pathways. ( 27031443 )
2016
25
Relevance of defensin β-2 and α defensins (HNP1-3) in Alzheimer's disease. ( 27082275 )
2016
26
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. ( 25352064 )
2015
27
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. ( 25503732 )
2015
28
Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant. ( 25815268 )
2015
29
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
30
Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission. ( 26379091 )
2015
31
Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. ( 26659570 )
2015
32
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. ( 24368192 )
2014
33
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. ( 24511990 )
2014
34
Translational study of the Notch pathway in hypertensive nephropathy. ( 24798563 )
2014
35
Renoprotective activity of aliskiren, a renin inhibitor in cyclosporine A induced hypertensive nephropathy in dTG mice. ( 24905308 )
2014
36
Relevance of α-defensins (HNP1-3) and defensin β-1 in diabetes. ( 25083086 )
2014
37
Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. ( 23192770 )
2013
38
Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province. ( 23673113 )
2013
39
Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans? ( 23815529 )
2013
40
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ( 24029866 )
2013
41
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ( 24116080 )
2013
42
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. ( 24223652 )
2013
43
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor. ( 24238127 )
2013
44
Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. ( 24648890 )
2013
45
Effect of RAS inhibition on TGF-β, renal function and structure in experimentally induced diabetic hypertensive nephropathy rats. ( 20089379 )
2013
46
Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1. ( 23498896 )
2013
47
Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function. ( 24236072 )
2013
48
Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. ( 21881553 )
2012
49
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. ( 22403621 )
2012
50
Hypertensive nephropathy in children - do we diagnose early enough? ( 22424480 )
2012

Variations for Hypertensive Nephropathy

Expression for Hypertensive Nephropathy

Search GEO for disease gene expression data for Hypertensive Nephropathy.

Pathways for Hypertensive Nephropathy

GO Terms for Hypertensive Nephropathy

Cellular components related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE ALB AMBP MIR26B POSTN VEGFA

Biological processes related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.43 ACE AGTR1 VEGFA
2 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.37 AGTR1 VEGFA
3 regulation of vasoconstriction GO:0019229 9.32 ACE AGTR1
4 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
5 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
6 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.62 ACE VEGFA

Molecular functions related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.16 ALB CYP3A4
2 heme binding GO:0020037 9.13 AMBP CYP3A4 CYP4A11
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Hypertensive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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