MCID: HYP114
MIFTS: 36

Hypertensive Nephropathy

Categories: Nephrological diseases

Aliases & Classifications for Hypertensive Nephropathy

MalaCards integrated aliases for Hypertensive Nephropathy:

Name: Hypertensive Nephropathy 57 13 73
Nephropathy Hypertensive 55
Hnp1 57

Classifications:



External Ids:

OMIM 57 608026
MedGen 42 C0848548
UMLS 73 C0848548

Summaries for Hypertensive Nephropathy

MalaCards based summary : Hypertensive Nephropathy, also known as nephropathy hypertensive, is related to malignant hypertension and chronic kidney failure. An important gene associated with Hypertensive Nephropathy is HNP1 (Hypertensive Nephropathy), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Constitutive Androstane Receptor Pathway. The drugs Diltiazem and Hydralazine have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver.

Description from OMIM: 608026

Related Diseases for Hypertensive Nephropathy

Diseases related to Hypertensive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 29.7 ACE AGTR1
2 chronic kidney failure 29.3 ACE AGTR1 ALB
3 iga glomerulonephritis 29.0 ACE AGTR1 ALB NAGLU
4 kidney disease 27.5 ACE AGTR1 ALB AMBP NAGLU
5 renal failure, progressive, with hypertension 11.4
6 allain-babin-demarquez syndrome 11.0
7 koro 10.7 ALB CYP3A4
8 severe nonproliferative diabetic retinopathy 10.6 ALB VEGFA
9 acute kidney tubular necrosis 10.6 ALB NAGLU
10 acroosteolysis 10.6 ALB VEGFA
11 background diabetic retinopathy 10.6 ALB VEGFA
12 lipoid nephrosis 10.6 ALB NAGLU
13 gastric lymphoma 10.6 ALB VEGFA
14 acute pyelonephritis 10.5 ALB NAGLU
15 hydrops, lactic acidosis, and sideroblastic anemia 10.4 ALB VEGFA
16 orthostatic proteinuria 10.4 ACE ALB
17 generalized atherosclerosis 10.4 ACE CYP4A11
18 syndrome of inappropriate antidiuretic hormone 10.4 ACE ALB
19 renal artery disease 10.3 ACE AGTR1
20 posterior urethral valves 10.2 ACE AGTR1
21 aortic coarctation 10.2 ACE AGTR1
22 diastolic heart failure 10.2 ACE AGTR1
23 neuroretinitis 10.2 ACE VEGFA
24 fibromuscular dysplasia 10.2 ACE AGTR1
25 portal hypertension 10.2 AGTR1 ALB VEGFA
26 hepatorenal syndrome 10.2 ACE ALB NAGLU
27 pyelonephritis 10.2 ACE ALB NAGLU
28 urinary system disease 10.1 ACE ALB NAGLU
29 renal tubular dysgenesis 10.1 ACE AGTR1
30 intermittent claudication 10.1 ACE ALB VEGFA
31 microvascular complications of diabetes 5 10.0 ACE ALB VEGFA
32 renovascular hypertension 10.0 ACE AGTR1
33 peripheral vascular disease 10.0 ACE ALB VEGFA
34 anuria 10.0 ACE AGTR1 ALB
35 renal hypertension 10.0 ACE AGTR1 ALB
36 autosomal dominant polycystic kidney disease 10.0 ACE ALB VEGFA
37 end stage renal failure 10.0 ACE AGTR1 ALB
38 nephrosclerosis 10.0 ACE AGTR1
39 xanthinuria, type i 10.0 AMBP NAGLU
40 oral squamous cell carcinoma 9.9
41 squamous cell carcinoma 9.9
42 acute mountain sickness 9.9 ACE AGTR1 VEGFA
43 ischemic optic neuropathy 9.8 ACE AGTR1
44 hepatopulmonary syndrome 9.8 ALB VEGFA
45 nephrolithiasis, calcium oxalate 9.8 AMBP NAGLU
46 hypertensive heart disease 9.7 ACE AGTR1
47 microvascular complications of diabetes 3 9.7 ACE AGTR1 ALB NAGLU
48 vesicoureteral reflux 1 9.6 AGTR1 AMBP NAGLU
49 hypertension, essential 9.6
50 stroke, ischemic 9.6

Graphical network of the top 20 diseases related to Hypertensive Nephropathy:



Diseases related to Hypertensive Nephropathy

Symptoms & Phenotypes for Hypertensive Nephropathy

Clinical features from OMIM:

608026

Drugs & Therapeutics for Hypertensive Nephropathy

Drugs for Hypertensive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diltiazem Approved, Investigational Phase 2, Phase 3 42399-41-7 39186
2
Hydralazine Approved Phase 2, Phase 3 86-54-4 3637
3
Ramipril Approved Phase 2, Phase 3 87333-19-5 5362129
4 Antihypertensive Agents Phase 2, Phase 3
5
Fluvastatin Approved 93957-54-1 1548972
6
Lovastatin Approved, Investigational 75330-75-5 53232
7
Pravastatin Approved 81093-37-0 54687
8
Simvastatin Approved 79902-63-9 54454
9 Anticholesteremic Agents
10 Antimetabolites
11 Atorvastatin Calcium 134523-03-8
12 Calcium, Dietary
13 Dihydromevinolin
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors
15 Hypolipidemic Agents
16 L 647318
17 Lipid Regulating Agents
18 Rosuvastatin Calcium 147098-20-2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 African American Study of Kidney Disease and Hypertension ABPM Pilot Study Completed NCT00582777 Phase 2, Phase 3 ADD On Dosing
2 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
3 Ayurvedic Management of Chronic Kidney Disease Recruiting NCT02477163
4 Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML) Recruiting NCT03280888
5 Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population Recruiting NCT02316522
6 Chongqing Primary Aldosteronism Study Recruiting NCT03224312
7 The Application of Microcurrent in Athletes Recruiting NCT03477747 Not Applicable
8 KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease Active, not recruiting NCT01630486
9 Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy Terminated NCT01881035 Not Applicable

Search NIH Clinical Center for Hypertensive Nephropathy

Genetic Tests for Hypertensive Nephropathy

Anatomical Context for Hypertensive Nephropathy

MalaCards organs/tissues related to Hypertensive Nephropathy:

41
Kidney, Endothelial, Liver, Heart

Publications for Hypertensive Nephropathy

Articles related to Hypertensive Nephropathy:

(show all 46)
# Title Authors Year
1
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy. ( 28244896 )
2017
2
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. ( 28808068 )
2017
3
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms. ( 27782909 )
2017
4
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis. ( 28713898 )
2017
5
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. ( 27255359 )
2016
6
Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats. ( 26823279 )
2016
7
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27754058 )
2016
8
An Analysis of Anthropometric Indicators and Modifiable Lifestyle Parameters Associated with Hypertensive Nephropathy. ( 27774313 )
2016
9
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27753857 )
2016
10
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27642978 )
2016
11
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile. ( 27756246 )
2016
12
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27643094 )
2016
13
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. ( 27558173 )
2016
14
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. ( 25503732 )
2015
15
Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant. ( 25815268 )
2015
16
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
17
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. ( 24368192 )
2014
18
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. ( 24511990 )
2014
19
Renoprotective activity of aliskiren, a renin inhibitor in cyclosporine A induced hypertensive nephropathy in dTG mice. ( 24905308 )
2014
20
Translational study of the Notch pathway in hypertensive nephropathy. ( 24798563 )
2014
21
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. ( 25352064 )
2014
22
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. ( 24223652 )
2013
23
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ( 24029866 )
2013
24
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor. ( 24238127 )
2013
25
Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans? ( 23815529 )
2013
26
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ( 24116080 )
2013
27
Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. ( 23192770 )
2013
28
Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. ( 24648890 )
2013
29
Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province. ( 23673113 )
2013
30
Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. ( 21881553 )
2012
31
Hypertensive nephropathy in children - do we diagnose early enough? ( 22424480 )
2012
32
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. ( 22403621 )
2012
33
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats. ( 23102665 )
2012
34
Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study. ( 21796127 )
2011
35
Gene polymorphism of vascular endothelial growth factor -1154 G&amp;gt;A is associated with hypertensive nephropathy in a Hispanic population. ( 21080079 )
2011
36
Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. ( 21475627 )
2011
37
Diabetic and hypertensive nephropathy in India. ( 21751620 )
2011
38
Increased mast cell number in human hypertensive nephropathy. ( 18684889 )
2008
39
Regression of hypertensive nephropathy during three years of optimal blood pressure control. ( 12918187 )
2003
40
African American hypertensive nephropathy maps to a new locus on chromosome 9q31-q32. ( 12840782 )
2003
41
[Hypertensive nephropathy: a growing cause of renal insufficiency]. ( 11244820 )
2001
42
Role of plasma and urinary endothelin-1 in early diabetic and hypertensive nephropathy. ( 9715792 )
1998
43
The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy. ( 9160765 )
1997
44
Hypertensive nephropathy and the gene for angiotensin-converting enzyme. ( 9081678 )
1997
45
Predictors for hypertensive nephropathy: results of a 6-year follow-up study in essential hypertension. ( 7622857 )
1995
46
Impact of antihypertensive therapy with isradipine and metoprolol on early markers of hypertensive nephropathy. ( 1533771 )
1992

Variations for Hypertensive Nephropathy

Expression for Hypertensive Nephropathy

Search GEO for disease gene expression data for Hypertensive Nephropathy.

Pathways for Hypertensive Nephropathy

GO Terms for Hypertensive Nephropathy

Cellular components related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE ALB AMBP MIR26B POSTN VEGFA

Biological processes related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of vasoconstriction GO:0019229 9.37 ACE AGTR1
2 kidney development GO:0001822 9.33 ACE AGTR1 VEGFA
3 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.32 AGTR1 VEGFA
4 regulation of blood vessel diameter GO:0097746 9.26 ACE AGTR1
5 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
6 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.62 ACE VEGFA

Molecular functions related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.33 AMBP CYP3A4 CYP4A11
2 oxygen binding GO:0019825 9.13 ALB CYP3A4 CYP4A11
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Hypertensive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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