HNP1
MCID: HYP114
MIFTS: 37

Hypertensive Nephropathy (HNP1)

Categories: Nephrological diseases

Aliases & Classifications for Hypertensive Nephropathy

MalaCards integrated aliases for Hypertensive Nephropathy:

Name: Hypertensive Nephropathy 58 13 74
Nephropathy Hypertensive 56
Hnp1 58

Classifications:



External Ids:

OMIM 58 608026
MedGen 43 C0848548
UMLS 74 C0848548

Summaries for Hypertensive Nephropathy

MalaCards based summary : Hypertensive Nephropathy, also known as nephropathy hypertensive, is related to microvascular complications of diabetes 3 and chronic kidney failure. An important gene associated with Hypertensive Nephropathy is HNP1 (Hypertensive Nephropathy), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Constitutive Androstane Receptor Pathway. The drugs Hydralazine and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Description from OMIM: 608026

Related Diseases for Hypertensive Nephropathy

Diseases related to Hypertensive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 29.9 ACE AGTR1 ALB
2 chronic kidney failure 29.8 ACE AGTR1 ALB
3 vesicoureteral reflux 1 29.7 AGTR1 AMBP NAGLU
4 kidney disease 29.6 ACE AGTR1 ALB AMBP NAGLU
5 iga glomerulonephritis 29.4 ACE AGTR1 ALB NAGLU
6 diabetes mellitus 28.5 ACE AGTR1 ALB MIR26B VEGFA
7 renal failure, progressive, with hypertension 11.6
8 allain-babin-demarquez syndrome 11.2
9 drug allergy 10.3 ALB CYP3A4
10 acute kidney tubular necrosis 10.3 ALB NAGLU
11 lipoid nephrosis 10.3 ALB NAGLU
12 severe nonproliferative diabetic retinopathy 10.3 ALB VEGFA
13 acute pyelonephritis 10.3 ALB NAGLU
14 acroosteolysis 10.3 ALB VEGFA
15 background diabetic retinopathy 10.2 ALB VEGFA
16 loeffler syndrome 10.2 ACE ALB
17 gastric lymphoma 10.2 ALB VEGFA
18 orthostatic proteinuria 10.2 ACE ALB
19 syndrome of inappropriate antidiuretic hormone 10.2 ACE ALB
20 renal artery disease 10.2 ACE AGTR1
21 hydrops, lactic acidosis, and sideroblastic anemia 10.2 ALB VEGFA
22 posterior urethral valves 10.2 ACE AGTR1
23 hepatorenal syndrome 10.2 ACE ALB
24 aortic coarctation 10.2 ACE AGTR1
25 generalized atherosclerosis 10.2 ACE CYP4A11
26 ischemic heart disease 10.2 ACE AGTR1
27 diastolic heart failure 10.2 ACE AGTR1
28 fibromuscular dysplasia 10.1 ACE AGTR1
29 xanthinuria, type i 10.1 AMBP NAGLU
30 oral squamous cell carcinoma 10.1
31 squamous cell carcinoma 10.1
32 renal tubular dysgenesis 10.1 ACE AGTR1
33 portal hypertension 10.1 AGTR1 ALB VEGFA
34 neuroretinitis 10.1 ACE VEGFA
35 pyelonephritis 10.1 ACE ALB NAGLU
36 renovascular hypertension 10.1 ACE AGTR1
37 nephrolithiasis, calcium oxalate 10.1 AMBP NAGLU
38 vein disease 10.1 ALB VEGFA
39 anuria 10.1 ACE AGTR1 ALB
40 renal hypertension 10.1 ACE AGTR1 ALB
41 nephrosclerosis 10.1 ACE AGTR1
42 hepatitis e 10.1 ALB AMBP
43 retinal artery occlusion 10.1 ACE VEGFA
44 end stage renal failure 10.0 ACE AGTR1 ALB
45 intermittent claudication 10.0 ACE ALB VEGFA
46 retinal vascular disease 10.0 ACE ALB VEGFA
47 peripheral vascular disease 10.0 ACE ALB VEGFA
48 nervous system disease 10.0 ACE ALB VEGFA
49 ischemic optic neuropathy 10.0 ACE AGTR1
50 autosomal dominant polycystic kidney disease 10.0 ACE ALB VEGFA

Graphical network of the top 20 diseases related to Hypertensive Nephropathy:



Diseases related to Hypertensive Nephropathy

Symptoms & Phenotypes for Hypertensive Nephropathy

Clinical features from OMIM:

608026

Drugs & Therapeutics for Hypertensive Nephropathy

Drugs for Hypertensive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydralazine Approved Phase 2, Phase 3 86-54-4 3637
2
Ramipril Approved Phase 2, Phase 3 87333-19-5 5362129
3
Diltiazem Approved, Investigational Phase 2, Phase 3 42399-41-7 39186
4 Antihypertensive Agents Phase 2, Phase 3
5
Simvastatin Approved 79902-63-9 54454
6
Pravastatin Approved 81093-37-0 54687
7
Lovastatin Approved, Investigational 75330-75-5 53232
8
Atorvastatin Approved 134523-00-5 60823
9
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
10
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
11
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
12
Testosterone Approved, Experimental, Investigational Not Applicable 58-22-0, 481-30-1 6013 10204
13
Calcium Approved, Nutraceutical 7440-70-2 271
14 L 647318
15 Dihydromevinolin
16 Calcium, Dietary
17 Lipid Regulating Agents
18 Anticholesteremic Agents
19 Hydroxymethylglutaryl-CoA Reductase Inhibitors
20 Antimetabolites
21 Hypolipidemic Agents
22 Rosuvastatin Calcium 147098-20-2
23 Hormones Not Applicable
24 Hydrocortisone 17-butyrate 21-propionate Not Applicable
25 Hydrocortisone hemisuccinate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 African American Study of Kidney Disease and Hypertension ABPM Pilot Study Completed NCT00582777 Phase 2, Phase 3 ADD On Dosing
2 Ayurvedic Management of Chronic Kidney Disease Unknown status NCT02477163
3 Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy Terminated NCT01881035 Not Applicable
4 KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease Active, not recruiting NCT01630486
5 Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML) Recruiting NCT03280888
6 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
7 Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population Recruiting NCT02316522
8 Chongqing Primary Aldosteronism Study Active, not recruiting NCT03224312
9 The Application of Microcurrent in Athletes Recruiting NCT03477747 Not Applicable

Search NIH Clinical Center for Hypertensive Nephropathy

Genetic Tests for Hypertensive Nephropathy

Anatomical Context for Hypertensive Nephropathy

MalaCards organs/tissues related to Hypertensive Nephropathy:

42
Kidney, Liver, Heart, Endothelial, Smooth Muscle

Publications for Hypertensive Nephropathy

Articles related to Hypertensive Nephropathy:

(show top 50) (show all 71)
# Title Authors Year
1
Comparison of serum levels of Cystatin-C and traditional renal biomarkers for the early detection of pre-hypertensive nephropathy. ( 30890820 )
2019
2
The predictive value of β2-MG and TGF-β for elderly hypertensive nephropathy. ( 30906478 )
2019
3
Prediction of Drug Positioning for Quan-Du-Zhong Capsules Against Hypertensive Nephropathy Based on the Robustness of Disease Network. ( 30809144 )
2019
4
Bioinformatic analysis reveals novel hub genes and pathways associated with hypertensive nephropathy. ( 30298691 )
2018
5
MiR-101a ameliorates AngII-mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF-κB signalling in a mouse model of hypertension. ( 30304543 )
2018
6
Patients with Hypertensive Nephropathy and Chronic Kidney Disease Might Not Benefit from Strict Blood Pressure Control. ( 30472714 )
2018
7
Combined Therapy of Hypertensive Nephropathy with Breviscapine Injection and Antihypertensive Drugs: A Systematic Review and a Meta-Analysis. ( 30671127 )
2018
8
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy. ( 28244896 )
2017
9
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. ( 28808068 )
2017
10
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms. ( 27782909 )
2017
11
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis. ( 28713898 )
2017
12
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. ( 27255359 )
2016
13
Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats. ( 26823279 )
2016
14
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27754058 )
2016
15
An Analysis of Anthropometric Indicators and Modifiable Lifestyle Parameters Associated with Hypertensive Nephropathy. ( 27774313 )
2016
16
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27753857 )
2016
17
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27642978 )
2016
18
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile. ( 27756246 )
2016
19
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27643094 )
2016
20
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. ( 27558173 )
2016
21
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. ( 25503732 )
2015
22
Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant. ( 25815268 )
2015
23
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
24
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. ( 24368192 )
2014
25
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. ( 24511990 )
2014
26
Renoprotective activity of aliskiren, a renin inhibitor in cyclosporine A induced hypertensive nephropathy in dTG mice. ( 24905308 )
2014
27
Translational study of the Notch pathway in hypertensive nephropathy. ( 24798563 )
2014
28
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. ( 25352064 )
2014
29
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. ( 24223652 )
2013
30
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ( 24029866 )
2013
31
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor. ( 24238127 )
2013
32
Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans? ( 23815529 )
2013
33
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ( 24116080 )
2013
34
Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. ( 23192770 )
2013
35
Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. ( 24648890 )
2013
36
Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province. ( 23673113 )
2013
37
Effect of RAS inhibition on TGF-β, renal function and structure in experimentally induced diabetic hypertensive nephropathy rats. ( 20089379 )
2013
38
Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. ( 21881553 )
2012
39
Hypertensive nephropathy in children - do we diagnose early enough? ( 22424480 )
2012
40
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. ( 22403621 )
2012
41
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats. ( 23102665 )
2012
42
Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study. ( 21796127 )
2011
43
Gene polymorphism of vascular endothelial growth factor -1154 G&amp;gt;A is associated with hypertensive nephropathy in a Hispanic population. ( 21080079 )
2011
44
Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. ( 21475627 )
2011
45
Diabetic and hypertensive nephropathy in India. ( 21751620 )
2011
46
Study of protein profiling of human urine in diabetic hypertensive nephropathy versus normal healthy controls. ( 20388048 )
2010
47
Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. ( 20445497 )
2010
48
Hypertensive nephropathy: prevention and treatment recommendations. ( 20718588 )
2010
49
The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. ( 19439518 )
2009
50
Increased mast cell number in human hypertensive nephropathy. ( 18684889 )
2008

Variations for Hypertensive Nephropathy

Expression for Hypertensive Nephropathy

Search GEO for disease gene expression data for Hypertensive Nephropathy.

Pathways for Hypertensive Nephropathy

GO Terms for Hypertensive Nephropathy

Cellular components related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE ALB AMBP MIR26B POSTN VEGFA

Biological processes related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.43 ACE AGTR1 VEGFA
2 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.37 AGTR1 VEGFA
3 regulation of vasoconstriction GO:0019229 9.32 ACE AGTR1
4 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
5 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
6 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.62 ACE VEGFA

Molecular functions related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.16 ALB CYP3A4
2 heme binding GO:0020037 9.13 AMBP CYP3A4 CYP4A11
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Hypertensive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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