HNP1
MCID: HYP114
MIFTS: 35

Hypertensive Nephropathy (HNP1)

Categories: Nephrological diseases

Aliases & Classifications for Hypertensive Nephropathy

MalaCards integrated aliases for Hypertensive Nephropathy:

Name: Hypertensive Nephropathy 57 13 70
Nephropathy Hypertensive 54
Hnp1 57

Classifications:



External Ids:

OMIM® 57 608026
MedGen 41 C0848548
UMLS 70 C0848548

Summaries for Hypertensive Nephropathy

MalaCards based summary : Hypertensive Nephropathy, also known as nephropathy hypertensive, is related to microvascular complications of diabetes 3 and nephrosclerosis. An important gene associated with Hypertensive Nephropathy is HNP1 (Hypertensive Nephropathy), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and A-beta Pathways: Plaque Formation and APP Metabolism. The drugs Losartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and heart, and related phenotypes are cardiovascular system and renal/urinary system

More information from OMIM: 608026

Related Diseases for Hypertensive Nephropathy

Diseases related to Hypertensive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 30.5 NAGLU ALB AGTR1 ACE
2 nephrosclerosis 29.9 VEGFA AGTR1 ACE
3 glomerular disease 29.9 NAGLU ALB ACE
4 end stage renal disease 29.8 VEGFA CST3 ALB AGTR1 ACE
5 proteinuria, chronic benign 29.7 VEGFA NAGLU AMBP ALB AGTR1 ACE
6 iga glomerulonephritis 29.7 NAGLU ALB AGTR1 ACE
7 kidney disease 29.6 NAGLU CST3 AMBP ALB AGTR1 ACE
8 hypertensive retinopathy 29.4 VEGFA ALB AGTR1 ACE
9 eclampsia 29.4 VEGFA ALB ACE
10 congestive heart failure 29.4 VEGFA ALB AGTR1 ACE
11 chronic kidney disease 29.4 VEGFA CST3 ALB AGTR1 ACE
12 vascular disease 29.2 VEGFA CST3 ALB ACE
13 hypertension, essential 28.4 VEGFA MIR26B CYP4A11 CYP3A4 CST3 AMBP
14 renal failure, progressive, with hypertension 11.1
15 allain-babin-demarquez syndrome 11.1
16 microvascular complications of diabetes 4 10.4
17 microvascular complications of diabetes 6 10.4
18 microvascular complications of diabetes 7 10.4
19 renal fibrosis 10.3
20 paralytic ileus 10.3 CYP3A4 ALB
21 inhibited female orgasm 10.3 CYP3A4 ALB
22 dysautonomia 10.2 ACTL7B ACTL7A
23 granulomatous hepatitis 10.2 ALB ACE
24 fanconi syndrome 10.2 NAGLU AMBP ALB
25 kidney papillary necrosis 10.2 ALB ACE
26 generalized atherosclerosis 10.2 ALB ACE
27 anthrax disease 10.2
28 intracranial embolism 10.2 ALB ACE
29 kidney hypertrophy 10.2 ALB ACE
30 constrictive pericarditis 10.2 ALB ACE
31 heart aneurysm 10.2 ALB ACE
32 posterior urethral valves 10.2 AGTR1 ACE
33 mucormycosis 10.1 CYP3A4 ALB
34 cranial nerve palsy 10.1 ALB ACE
35 fibromuscular dysplasia 10.1 AGTR1 ACE
36 idiopathic nephrotic syndrome 10.1 ALB ACE
37 malignant hypertension 10.1
38 alzheimer disease 5 10.1 AGTR1 ACE
39 inappropriate adh syndrome 10.1 ALB ACE
40 mild cognitive impairment 10.1 CST3 ACE
41 acute pyelonephritis 10.1 NAGLU ALB ACE
42 urinary tract obstruction 10.1 NAGLU ALB ACE
43 mobitz type ii atrioventricular block 10.1 AMBP ACE
44 ureteral disease 10.1 ALB AGTR1 ACE
45 glomerulonephritis 10.1
46 arteriolosclerosis 10.1
47 renal hypertension 10.1 ALB AGTR1 ACE
48 orthostatic proteinuria 10.1 CST3 ALB ACE
49 interstitial nephritis 10.1 ALB AGTR1 ACE
50 obstructive nephropathy 10.0 AMBP ALB ACE

Graphical network of the top 20 diseases related to Hypertensive Nephropathy:



Diseases related to Hypertensive Nephropathy

Symptoms & Phenotypes for Hypertensive Nephropathy

Clinical features from OMIM®:

608026 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Hypertensive Nephropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ACE ACTL7B AGTR1 ALB CST3 CYP4A11
2 renal/urinary system MP:0005367 9.17 ACE ACTL7B AGTR1 ALB CYP4A11 NAGLU

Drugs & Therapeutics for Hypertensive Nephropathy

Drugs for Hypertensive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
3
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
4
Lactitol Approved, Investigational Phase 4 585-86-4 157355
5 Anti-Arrhythmia Agents Phase 4
6 Angiotensin II Type 1 Receptor Blockers Phase 4
7 Angiotensin Receptor Antagonists Phase 4
8 Giapreza Phase 4
9 Angiotensinogen Phase 4
10 Antihypertensive Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Nighttime Losartan on Prognosis of Nocturnal Hypertension Patients Undergoing Continous Ambulatory Peritoneal Dialysis Not yet recruiting NCT03692013 Phase 4 Losartan
2 Effect of Nighttime Valsartan on Prognosis of Nocturnal Hypertension Patients Undergoing Maintenance Hemodialysis Not yet recruiting NCT03594825 Phase 4 Valsartan
3 Effects of Nocturnal Hypertension on Sleep Quality in Renal Transplant Recipients Unknown status NCT03651492
4 Effectiveness of Implementation of a Patient-centered Self-management Program in Patients With Hypertensive Nephropathy Recruiting NCT04633993
5 Whole Exome Sequencing Analysis Project in Chronic Kidney Disease Patients With Nocturnal Hypertension Recruiting NCT03718585

Search NIH Clinical Center for Hypertensive Nephropathy

Genetic Tests for Hypertensive Nephropathy

Anatomical Context for Hypertensive Nephropathy

MalaCards organs/tissues related to Hypertensive Nephropathy:

40
Kidney, Neutrophil, Heart, Endothelial, Liver, Monocytes, Cortex

Publications for Hypertensive Nephropathy

Articles related to Hypertensive Nephropathy:

(show top 50) (show all 619)
# Title Authors PMID Year
1
African American hypertensive nephropathy maps to a new locus on chromosome 9q31-q32. 57 61
12840782 2003
2
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway. 61 54
18403595 2008
3
[Early diagnosis of renal damage in hypertensive patients]. 61 54
15532373 2004
4
The case for combining angiotensin-converting enzyme inhibitors and calcium-channel blockers. 54 61
10981104 1999
5
[Comparative evaluation of ACE inhibitors: which differences are relevant?]. 54 61
10464907 1999
6
[Microalbuminuria in arterial hypertension]. 61 54
9710992 1998
7
Urinary calprotectin, NGAL, and KIM-1 in the differentiation of primarily inflammatory vs. non-inflammatory stable chronic kidney diseases. 61
33663323 2021
8
[West-Nile-Virus Infection acquired in Germany in a Kidney Transplant Recipient]. 61
33780997 2021
9
Mechanism of herbal medicine on hypertensive nephropathy (Review). 61
33537809 2021
10
Natural products: potential treatments for cisplatin-induced nephrotoxicity. 61
33750909 2021
11
Kidney Biopsy in Type 2 Diabetes: A Multicenter Cross-Sectional Study. 61
33780924 2021
12
The role of Elabela in kidney disease. 61
33683568 2021
13
Human neutrophil peptides 1-3 level in patients with acute myocardial infarction and its relation with coronary artery disease severity. 61
33709917 2021
14
Atherosclerotic-nephropathy: an updated narrative review. 61
32270411 2021
15
24-h ambulatory blood pressure variability and hypertensive nephropathy in Han Chinese hypertensive patients. 61
33222387 2021
16
Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy: a cohort study. 61
32740292 2021
17
Multicenter Investigation of the Initial Hemodialysis Vascular Access and Its Related Factors in Hangzhou of China. 61
33681358 2021
18
Catalytic Antioxidants in the Kidney. 61
33477607 2021
19
Gastrin, via activation of PPARα, protects the kidney against hypertensive injury. 61
33458737 2021
20
Different clinical impact of hyperuricemia according to etiologies of chronic kidney disease: Gonryo Study. 61
33765101 2021
21
Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation. 61
33420397 2021
22
Bioinformatic gene analysis for possible biomarkers and therapeutic targets of hypertension-related renal cell carcinoma. 61
33457239 2020
23
Daily Low-intensity Pulsed Ultrasound Ameliorates Renal Fibrosis and Inflammation in Experimental Hypertensive and Diabetic Nephropathy. 61
33131306 2020
24
Cooperative Function of LL-37 and HNP1 Protects Mammalian Cell Membranes from Lysis. 61
33157121 2020
25
Protection or Destruction: The LL-37/HNP1 Cooperativity Switch. 61
33271082 2020
26
The correlation of circulating miR-29b and inflammatory markers with albuminuria in hypertensive patients. 61
32631160 2020
27
Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy. 61
32971570 2020
28
Identification of biomarkers and pathways in hypertensive nephropathy based on the ceRNA regulatory network. 61
33176720 2020
29
The research status and prospect of Periostin in chronic kidney disease. 61
33241962 2020
30
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells. 61
32865013 2020
31
[Network Meta-analysis of Huoxue Huayu Chinese medicine injections on hypertensive nephropathy]. 61
33350275 2020
32
The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: baseline characteristics. 61
32862232 2020
33
Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: a randomized controlled trial. 61
33001255 2020
34
Analysis of the correlations of hypertension complicated with or without hypertensive nephropathy with glucose and lipid metabolism, vascular endothelial function, inflammation, oxidative stress and course of disease. 61
31144793 2020
35
MicroRNAs in Chronic Kidney Disease: Four Candidates for Clinical Application. 61
32906849 2020
36
Aetiology of chronic kidney disease and risk factors for disease progression in Chinese subjects: A single-centre retrospective study in Beijing. 61
32180286 2020
37
Optimal blood pressure for the prevention of hypertensive nephropathy in nondiabetic hypertensive patients in Taiwan. 61
32762119 2020
38
Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2). 61
32759311 2020
39
CKD in China: Evolving Spectrum and Public Health Implications. 61
31492486 2020
40
Hypertensive nephropathy: a major roadblock hindering the advance of precision nephrology. 61
32897275 2020
41
Epicardial fat, cardiovascular risk factors and calcifications in patients with chronic kidney disease. 61
32905245 2020
42
Proteomics-Based Machine Learning Approach as an Alternative to Conventional Biomarkers for Differential Diagnosis of Chronic Kidney Diseases. 61
32645927 2020
43
MicroRNA and mRNA analysis of angiotensin II-induced renal artery endothelial cell dysfunction. 61
32346437 2020
44
Qian Yang Yu Yin Granule protects against hypertension-induced renal injury by epigenetic mechanism linked to Nicotinamide N-Methyltransferase (NNMT) expression. 61
32147479 2020
45
Should We Perform Old-for-Old Kidney Transplantation during the COVID-19 Pandemic? The Risk for Post-Operative Intensive Stay. 61
32545566 2020
46
Blood pressure control in chronic kidney disease according to underlying renal disease: the Fukushima CKD cohort. 61
31875937 2020
47
ROCK (RhoA/Rho Kinase) in Cardiovascular-Renal Pathophysiology: A Review of New Advancements. 61
32370294 2020
48
Effect of gasotransmitters treatment on expression of hypertension, vascular and cardiac remodeling and hypertensive nephropathy genes in left ventricular hypertrophy. 61
32068124 2020
49
Diminished systemic levels of antimicrobial peptides in tuberculous lymphadenitis and their reversal after anti-tuberculosis treatment. 61
32275232 2020
50
Collagen receptor- and metalloproteinase-dependent hypertensive stress response in mesangial and glomerular endothelial cells. 61
31912277 2020

Variations for Hypertensive Nephropathy

Expression for Hypertensive Nephropathy

Search GEO for disease gene expression data for Hypertensive Nephropathy.

Pathways for Hypertensive Nephropathy

Pathways related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.13 VEGFA RAC1 AGTR1
2 10.62 CST3 ACE
3 10.39 VEGFA POSTN
4
Show member pathways
9.66 CYP3A4 AGTR1

GO Terms for Hypertensive Nephropathy

Cellular components related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 VEGFA POSTN MIR26B CST3 AMBP ALB
2 dynactin complex GO:0005869 8.62 ACTL7B ACTL7A

Biological processes related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of vasoconstriction GO:0019229 9.26 AGTR1 ACE
2 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.16 AGTR1 ACE
3 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.96 VEGFA ACE
4 kidney development GO:0001822 8.92 VEGFA CYP4A11 AGTR1 ACE

Molecular functions related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.13 CYP4A11 CYP3A4 AMBP
2 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Hypertensive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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