HNP1
MCID: HYP114
MIFTS: 32

Hypertensive Nephropathy (HNP1)

Categories: Nephrological diseases

Aliases & Classifications for Hypertensive Nephropathy

MalaCards integrated aliases for Hypertensive Nephropathy:

Name: Hypertensive Nephropathy 57 13 73
Nephropathy Hypertensive 55
Hnp1 57

Classifications:



External Ids:

OMIM 57 608026
MedGen 42 C0848548
UMLS 73 C0848548

Summaries for Hypertensive Nephropathy

MalaCards based summary : Hypertensive Nephropathy, also known as nephropathy hypertensive, is related to chronic kidney failure and microvascular complications of diabetes 3. An important gene associated with Hypertensive Nephropathy is HNP1 (Hypertensive Nephropathy), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Constitutive Androstane Receptor Pathway. The drugs Hydralazine and Diltiazem have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart.

Description from OMIM: 608026

Related Diseases for Hypertensive Nephropathy

Diseases related to Hypertensive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 chronic kidney failure 29.8 ACE AGTR1 ALB
2 microvascular complications of diabetes 3 29.6 ACE AGTR1 ALB
3 kidney disease 29.6 ACE AGTR1 ALB AMBP NAGLU
4 iga glomerulonephritis 29.5 ACE AGTR1 ALB NAGLU
5 diabetes mellitus 28.9 ACE AGTR1 ALB MIR26B VEGFA
6 renal failure, progressive, with hypertension 11.6
7 allain-babin-demarquez syndrome 11.1
8 drug allergy 10.2 ALB CYP3A4
9 acute kidney tubular necrosis 10.2 ALB NAGLU
10 lipoid nephrosis 10.2 ALB NAGLU
11 severe nonproliferative diabetic retinopathy 10.2 ALB VEGFA
12 acute pyelonephritis 10.2 ALB NAGLU
13 acroosteolysis 10.2 ALB VEGFA
14 background diabetic retinopathy 10.2 ALB VEGFA
15 loeffler syndrome 10.2 ACE ALB
16 gastric lymphoma 10.2 ALB VEGFA
17 orthostatic proteinuria 10.1 ACE ALB
18 syndrome of inappropriate antidiuretic hormone 10.1 ACE ALB
19 renal artery disease 10.1 ACE AGTR1
20 hydrops, lactic acidosis, and sideroblastic anemia 10.1 ALB VEGFA
21 posterior urethral valves 10.1 ACE AGTR1
22 hepatorenal syndrome 10.1 ACE ALB
23 aortic coarctation 10.1 ACE AGTR1
24 generalized atherosclerosis 10.1 ACE CYP4A11
25 malignant hypertension 10.1 ACE AGTR1
26 diastolic heart failure 10.1 ACE AGTR1
27 fibromuscular dysplasia 10.1 ACE AGTR1
28 oral squamous cell carcinoma 10.1
29 squamous cell carcinoma 10.1
30 renal tubular dysgenesis 10.1 ACE AGTR1
31 xanthinuria, type i 10.1 AMBP NAGLU
32 portal hypertension 10.1 AGTR1 ALB VEGFA
33 renovascular hypertension 10.1 ACE AGTR1
34 neuroretinitis 10.1 ACE VEGFA
35 pyelonephritis 10.1 ACE ALB NAGLU
36 nephrosclerosis 10.1 ACE AGTR1
37 anuria 10.0 ACE AGTR1 ALB
38 vein disease 10.0 ALB VEGFA
39 renal hypertension 10.0 ACE AGTR1 ALB
40 retinal artery occlusion 10.0 ACE VEGFA
41 end stage renal failure 10.0 ACE AGTR1 ALB
42 nephrolithiasis, calcium oxalate 10.0 AMBP NAGLU
43 hepatitis e 10.0 ALB AMBP
44 vesicoureteral reflux 1 10.0 AGTR1 AMBP NAGLU
45 intermittent claudication 10.0 ACE ALB VEGFA
46 retinal vascular disease 10.0 ACE ALB VEGFA
47 peripheral vascular disease 10.0 ACE ALB VEGFA
48 autosomal dominant polycystic kidney disease 10.0 ACE ALB VEGFA
49 nervous system disease 10.0 ACE ALB VEGFA
50 ischemic optic neuropathy 10.0 ACE AGTR1

Graphical network of the top 20 diseases related to Hypertensive Nephropathy:



Diseases related to Hypertensive Nephropathy

Symptoms & Phenotypes for Hypertensive Nephropathy

Clinical features from OMIM:

608026

Drugs & Therapeutics for Hypertensive Nephropathy

Drugs for Hypertensive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydralazine Approved Phase 2, Phase 3 86-54-4 3637
2
Diltiazem Approved, Investigational Phase 2, Phase 3 42399-41-7 39186
3
Ramipril Approved Phase 2, Phase 3 87333-19-5 5362129
4 Antihypertensive Agents Phase 2, Phase 3
5
Fluvastatin Approved 93957-54-1 1548972
6
Simvastatin Approved 79902-63-9 54454
7
Lovastatin Approved, Investigational 75330-75-5 53232
8
Pravastatin Approved 81093-37-0 54687
9
Hydrocortisone acetate Approved, Vet_approved Not Applicable 50-03-3
10
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
11
Hydrocortisone Approved, Vet_approved Not Applicable 50-23-7 5754
12
Testosterone Approved, Investigational Not Applicable 58-22-0 6013
13 L 647318
14 Atorvastatin Calcium 134523-03-8
15 Calcium, Dietary
16 Hydroxymethylglutaryl-CoA Reductase Inhibitors
17 Anticholesteremic Agents
18 Dihydromevinolin
19 Lipid Regulating Agents
20 Rosuvastatin Calcium 147098-20-2
21 Antimetabolites
22 Hypolipidemic Agents
23 Hydrocortisone 17-butyrate 21-propionate Not Applicable
24 Hormones Not Applicable
25 Cortisol succinate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 African American Study of Kidney Disease and Hypertension ABPM Pilot Study Completed NCT00582777 Phase 2, Phase 3 ADD On Dosing
2 Ayurvedic Management of Chronic Kidney Disease Unknown status NCT02477163
3 Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy Terminated NCT01881035 Not Applicable
4 KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease Active, not recruiting NCT01630486
5 Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML) Recruiting NCT03280888
6 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
7 Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population Recruiting NCT02316522
8 Chongqing Primary Aldosteronism Study Recruiting NCT03224312
9 The Application of Microcurrent in Athletes Recruiting NCT03477747 Not Applicable

Search NIH Clinical Center for Hypertensive Nephropathy

Genetic Tests for Hypertensive Nephropathy

Anatomical Context for Hypertensive Nephropathy

MalaCards organs/tissues related to Hypertensive Nephropathy:

41
Kidney, Liver, Heart, Endothelial, Smooth Muscle

Publications for Hypertensive Nephropathy

Articles related to Hypertensive Nephropathy:

(show top 50) (show all 67)
# Title Authors Year
1
Bioinformatic analysis reveals novel hub genes and pathways associated with hypertensive nephropathy. ( 30298691 )
2018
2
MiR-101a ameliorates AngII-mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF-κB signalling in a mouse model of hypertension. ( 30304543 )
2018
3
Patients with Hypertensive Nephropathy and Chronic Kidney Disease Might Not Benefit from Strict Blood Pressure Control. ( 30472714 )
2018
4
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy. ( 28244896 )
2017
5
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. ( 28808068 )
2017
6
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms. ( 27782909 )
2017
7
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis. ( 28713898 )
2017
8
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. ( 27255359 )
2016
9
Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats. ( 26823279 )
2016
10
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27754058 )
2016
11
An Analysis of Anthropometric Indicators and Modifiable Lifestyle Parameters Associated with Hypertensive Nephropathy. ( 27774313 )
2016
12
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27753857 )
2016
13
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27642978 )
2016
14
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile. ( 27756246 )
2016
15
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27643094 )
2016
16
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. ( 27558173 )
2016
17
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. ( 25503732 )
2015
18
Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant. ( 25815268 )
2015
19
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
20
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. ( 24368192 )
2014
21
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. ( 24511990 )
2014
22
Renoprotective activity of aliskiren, a renin inhibitor in cyclosporine A induced hypertensive nephropathy in dTG mice. ( 24905308 )
2014
23
Translational study of the Notch pathway in hypertensive nephropathy. ( 24798563 )
2014
24
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. ( 25352064 )
2014
25
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. ( 24223652 )
2013
26
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ( 24029866 )
2013
27
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor. ( 24238127 )
2013
28
Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans? ( 23815529 )
2013
29
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ( 24116080 )
2013
30
Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. ( 23192770 )
2013
31
Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. ( 24648890 )
2013
32
Effect of RAS inhibition on TGF-β, renal function and structure in experimentally induced diabetic hypertensive nephropathy rats. ( 20089379 )
2013
33
Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province. ( 23673113 )
2013
34
Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. ( 21881553 )
2012
35
Hypertensive nephropathy in children - do we diagnose early enough? ( 22424480 )
2012
36
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. ( 22403621 )
2012
37
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats. ( 23102665 )
2012
38
Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study. ( 21796127 )
2011
39
Gene polymorphism of vascular endothelial growth factor -1154 G&amp;gt;A is associated with hypertensive nephropathy in a Hispanic population. ( 21080079 )
2011
40
Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. ( 21475627 )
2011
41
Diabetic and hypertensive nephropathy in India. ( 21751620 )
2011
42
Study of protein profiling of human urine in diabetic hypertensive nephropathy versus normal healthy controls. ( 20388048 )
2010
43
Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. ( 20445497 )
2010
44
Hypertensive nephropathy: prevention and treatment recommendations. ( 20718588 )
2010
45
The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. ( 19439518 )
2009
46
Increased mast cell number in human hypertensive nephropathy. ( 18684889 )
2008
47
Hepatocyte nuclear factor 1 and hypertensive nephropathy. ( 18443232 )
2008
48
Should a lower blood pressure goal and albuminuria reduction be mandated to slow hypertensive nephropathy? ( 18775116 )
2008
49
The renin-angiotensin system in glomerular podocytes: mediator of glomerulosclerosis and link to hypertensive nephropathy. ( 16672146 )
2006
50
Mechanism of hypertensive nephropathy in the Dahl/Rapp rat: a primary disorder of vascular smooth muscle. ( 15583217 )
2005

Variations for Hypertensive Nephropathy

Expression for Hypertensive Nephropathy

Search GEO for disease gene expression data for Hypertensive Nephropathy.

Pathways for Hypertensive Nephropathy

GO Terms for Hypertensive Nephropathy

Cellular components related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE ALB AMBP MIR26B POSTN VEGFA

Biological processes related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.43 ACE AGTR1 VEGFA
2 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.37 AGTR1 VEGFA
3 regulation of vasoconstriction GO:0019229 9.32 ACE AGTR1
4 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
5 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
6 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.62 ACE VEGFA

Molecular functions related to Hypertensive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.16 ALB CYP3A4
2 heme binding GO:0020037 9.13 AMBP CYP3A4 CYP4A11
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Hypertensive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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