MCID: HYP008
MIFTS: 37

Hypertensive Retinopathy

Categories: Eye diseases

Aliases & Classifications for Hypertensive Retinopathy

MalaCards integrated aliases for Hypertensive Retinopathy:

Name: Hypertensive Retinopathy 12 76 29 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11561
ICD10 33 H35.03
ICD9CM 35 362.11
MeSH 44 D058437
NCIt 50 C3514
UMLS 73 C0152132

Summaries for Hypertensive Retinopathy

MalaCards based summary : Hypertensive Retinopathy is related to malignant hypertension and coronary heart disease 1. An important gene associated with Hypertensive Retinopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Angiogenesis (CST) and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Angiotensin-Converting Enzyme Inhibitors and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include retina, brain and eye, and related phenotype is cardiovascular system.

Wikipedia : 76 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

Related Diseases for Hypertensive Retinopathy

Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 30.2 ACE REN
2 coronary heart disease 1 30.0 ACE ADIPOQ
3 renovascular hypertension 29.7 ACE REN
4 coronary artery anomaly 29.3 ACE ADIPOQ VWF
5 chronic kidney failure 28.8 ACE ADIPOQ REN
6 pre-eclampsia 28.4 ADIPOQ REN VWF
7 hypertension, essential 28.2 ACE ADIPOQ REN VWF
8 heart disease 28.2 ACE ADIPOQ REN VWF
9 arteries, anomalies of 28.0 ACE ADIPOQ REN VWF
10 vascular disease 28.0 ACE ADIPOQ REN VWF
11 idiopathic edema 10.5 ACE ADIPOQ
12 angina pectoris 10.4 ACE VWF
13 intermittent claudication 10.3 ACE VWF
14 arteritic anterior ischemic optic neuropathy 10.3 ACE FANCG
15 limb ischemia 10.3 ACE VWF
16 coronary stenosis 10.3 ACE VWF
17 lipid metabolism disorder 10.2 ACE ADIPOQ
18 peripheral vascular disease 10.1 ACE VWF
19 retinitis 10.1
20 hyporeninemic hypoaldosteronism 10.1 ACE REN
21 renal artery obstruction 10.1 ACE REN
22 hypoaldosteronism 10.0 ACE REN
23 hypertensive encephalopathy 10.0 ACE REN
24 renal artery disease 10.0 ACE REN
25 hypertension, diastolic 10.0 ACE REN
26 orthostatic proteinuria 10.0 ACE REN
27 atrial septal defect 4 10.0 ACE REN
28 malignant essential hypertension 10.0 ACE REN
29 anuria 10.0 ACE REN
30 pheochromocytoma 10.0
31 fibromuscular dysplasia 10.0 ACE REN
32 renal hypertension 10.0 ACE REN
33 arteriolosclerosis 10.0 ADIPOQ REN
34 hepatorenal syndrome 10.0 ACE REN
35 renal tubular dysgenesis 10.0 ACE REN
36 pure autonomic failure 10.0 ACE REN
37 ureteral disease 9.9 ACE REN
38 pseudohyperkalemia, familial, 2, due to red cell leak 9.9 ACE REN
39 apnea, obstructive sleep 9.9 ADIPOQ REN
40 interstitial nephritis 9.9 ACE REN
41 microvascular complications of diabetes 3 9.9 ACE REN
42 oligohydramnios 9.9 ACE REN
43 neuropathy 9.8
44 immune system disease 9.8 ACE VWF
45 pulmonary edema 9.8 ACE REN
46 hypokalemia 9.8 ACE REN
47 polycystic kidney disease 1 with or without polycystic liver disease 9.8 ACE REN
48 neuroretinitis 9.8
49 eclampsia 9.8
50 optic nerve disease 9.8

Comorbidity relations with Hypertensive Retinopathy via Phenotypic Disease Network (PDN):


Deficiency Anemia Hypertension, Essential
Malignant Essential Hypertension

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to Hypertensive Retinopathy

Symptoms & Phenotypes for Hypertensive Retinopathy

MGI Mouse Phenotypes related to Hypertensive Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 ACE ADIPOQ FTH1 REN VWF

Drugs & Therapeutics for Hypertensive Retinopathy

Drugs for Hypertensive Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Angiotensin-Converting Enzyme Inhibitors Phase 1
2 Antihypertensive Agents Phase 1
3 calcium channel blockers Phase 1
4 Calcium, Dietary Phase 1
5
Carbon monoxide Approved, Investigational 630-08-0 281
6
Menthol Approved 2216-51-5 16666
7
Glucosamine Approved, Investigational, Nutraceutical Not Applicable 3416-24-8 439213
8 Anticoagulants Not Applicable
9 Antimetabolites Not Applicable
10 Fibrinolytic Agents Not Applicable
11 Glucuronyl glucosamine glycan sulfate Not Applicable
12 Hypoglycemic Agents Not Applicable
13 Hypolipidemic Agents Not Applicable
14 Lipid Regulating Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children Completed NCT00178490 Phase 1 High blood pressure treatment
2 The Effect of Pre-discharge Blood Pressure of Patients With Asymptomatic Severe Hypertension in Emergency Department Completed NCT02534324 Antihypertensive meds
3 Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors Completed NCT01630928 Not Applicable
4 Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation Completed NCT01820117
5 Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy Recruiting NCT01753648 Not Applicable
6 Morbidity in Patients With Hypertension and Obstructive Sleep Apnea Recruiting NCT02270658 Not Applicable
7 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Hypertensive Retinopathy

Cochrane evidence based reviews: hypertensive retinopathy

Genetic Tests for Hypertensive Retinopathy

Genetic tests related to Hypertensive Retinopathy:

# Genetic test Affiliating Genes
1 Hypertensive Retinopathy 29

Anatomical Context for Hypertensive Retinopathy

MalaCards organs/tissues related to Hypertensive Retinopathy:

41
Retina, Brain, Eye, Heart, Endothelial, Liver, Kidney

Publications for Hypertensive Retinopathy

Articles related to Hypertensive Retinopathy:

(show top 50) (show all 160)
# Title Authors Year
1
Manually segmented vascular networks from images of retina with proliferative diabetic and hypertensive retinopathy. ( 29900203 )
2018
2
Association between heart failure with preserved ejection fraction and hypertensive retinopathy: more questions than answers! ( 29662140 )
2018
3
Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy. ( 29441752 )
2018
4
Arteriovenous ratio and papilledema based hybrid decision support system for detection and grading of hypertensive retinopathy. ( 29249337 )
2018
5
Relationship between nocturnal blood pressure profiles and the presence and severity of hypertensive retinopathy. ( 29525287 )
2018
6
Assessment of left atrium and diastolic dysfunction in patients with hypertensive retinopathy: A real-time three-dimensional echocardiography-based study. ( 28758803 )
2017
7
Hypertensive retinopathy as the initial presentation of neuroblastoma. ( 29260095 )
2017
8
Changes in thickness of central macula and retinal nerve fibre layer in severe hypertensive retinopathy: a 1-year longitudinal study. ( 28975766 )
2017
9
Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults. ( 28577362 )
2017
10
Consideration of hypertensive retinopathy as an important end-organ damage in patients with hypertension. ( 27465980 )
2016
11
Proliferative Hypertensive Retinopathy. ( 26767543 )
2016
12
Review of hypertensive retinopathy. ( 27931746 )
2016
13
P1113Relationship between left atrium and hypertensive retinopathy in patients with systemic hypertension: a real-time three-dimensional echocardiography-based study. ( 28415121 )
2016
14
Multimodal Imaging of Elschnig Spots: A Case of Simultaneous Hypertensive Retinopathy, Choroidopathy, and Neuropathy. ( 27082847 )
2016
15
Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion. ( 27795862 )
2016
16
Hypertensive retinopathy and cerebral small vessel disease in Amerindians living in rural Ecuador: The Atahualpa Project. ( 27232913 )
2016
17
Hypertensive retinopathy in a transgenic angiotensin-based model. ( 27026533 )
2016
18
Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. ( 26167496 )
2015
19
7D.08: DETECTING HYPERTENSIVE RETINOPATHY USING RETINAL VASCULAR GEOMETRY. ( 26102655 )
2015
20
Relationship of Hypertensive Retinopathy with Mean Platelet Volume Among Hypertensive Patients. ( 26835193 )
2015
21
Diabetes retinopathy is a poor predictor for renal and cardiovascular outcomes in comparison with hypertensive retinopathy in patients with chronic kidney disease. ( 26008724 )
2015
22
Bilateral hypertensive retinopathy diagnostic of pheochromocytoma. ( 25443213 )
2015
23
Tremendous result of bevacizumab in malignant hypertensive retinopathy. ( 25709280 )
2015
24
Hypertensive Retinopathy as the First Manifestation of Advanced Renal Disease in a Young Patient: Report of a Case. ( 26955342 )
2015
25
The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: association with target organ damage in individuals below 55 years. ( 26335430 )
2015
26
Hypertensive Retinopathy, Choroidopathy, and Optic Neuropathy. ( 26448430 )
2015
27
Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus. ( 26082609 )
2015
28
Hypertensive retinopathy revealing a pheochromocytoma associated with a liver hydatid cyst in a child. ( 25955378 )
2015
29
Updated classification of hypertensive retinopathy: which role for cardiovascular risk stratification? ( 26425835 )
2015
30
The association between endothelial dysfunction and hypertensive retinopathy in essential hypertension. ( 24441931 )
2014
31
Images in clinical medicine. Hypertensive retinopathy associated with preeclampsia. ( 24552322 )
2014
32
Detection of hypertensive retinopathy using vessel measurements and textural features. ( 25571216 )
2014
33
Hypertensive retinopathy and its association with cardiovascular, renal and cerebrovascular morbidity in Congolese patients. ( 25629539 )
2014
34
Bilateral Hypertensive Retinopathy Complicated with Retinal Neovascularization: Panretinal Photocoagulation or Intravitreal Anti-VEGF Treatment? ( 25232335 )
2014
35
The association of oxidative stress with hypertensive retinopathy. ( 22571627 )
2013
36
Hypertensive retinopathy: comparing the Keith-Wagener-Barker to a simplified classification. ( 23449021 )
2013
37
Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. ( 23148140 )
2013
38
Hypertensive retinopathy in severely hypertensive children: demographic, clinical, and ophthalmoscopic findings from a 30-year British cohort. ( 23521027 )
2013
39
Hypertensive retinopathy and risk of stroke. ( 23940194 )
2013
40
Effect of intravitreal bevacizumab (Avastin(Ar)) therapy in malignant hypertensive retinopathy: a report of two cases. ( 22149905 )
2012
41
Hypertensive retinopathy in a child caused by pheochromocytoma: identification after a failed school vision screening. ( 22245022 )
2012
42
Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure. ( 23359839 )
2012
43
Hypertensive retinopathy: incidence, risk factors, and comorbidities. ( 22468968 )
2012
44
Restoration of outer segments of foveal photoreceptors after resolution of malignant hypertensive retinopathy. ( 23275917 )
2012
45
Microalbuminuria and hypertensive retinopathy among newly diagnosed nondiabetic hypertensive adult Nigerians. ( 22248945 )
2011
46
Hypertensive retinopathy and visual outcome in hypertensive disorders in pregnancy. ( 23765142 )
2011
47
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. ( 21214413 )
2011
48
Hypertensive retinopathy in a child. ( 20693485 )
2011
49
Support system for the preventive diagnosis of hypertensive retinopathy. ( 21097309 )
2010
50
Relation between grade II hypertensive retinopathy and coronary artery disease in treated essential hypertensives. ( 21029012 )
2010

Variations for Hypertensive Retinopathy

Expression for Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for Hypertensive Retinopathy

Pathways related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 REN VWF
2
Show member pathways
10.86 ACE REN
3 10.44 ACE REN

GO Terms for Hypertensive Retinopathy

Cellular components related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 ACE ADIPOQ FTH1 REN VWF

Biological processes related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.26 ACE REN
2 cellular response to drug GO:0035690 9.16 ADIPOQ REN
3 amyloid-beta metabolic process GO:0050435 8.96 ACE REN
4 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Hypertensive Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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