MCID: HYP008
MIFTS: 39

Hypertensive Retinopathy

Categories: Neuronal diseases

Aliases & Classifications for Hypertensive Retinopathy

MalaCards integrated aliases for Hypertensive Retinopathy:

Name: Hypertensive Retinopathy 12 73 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11561
ICD9CM 34 362.11
MeSH 44 D058437
NCIt 50 C3514
SNOMED-CT 67 422001004
ICD10 32 H35.03
UMLS 70 C0152132

Summaries for Hypertensive Retinopathy

MalaCards based summary : Hypertensive Retinopathy is related to retinal vascular disease and macular retinal edema. An important gene associated with Hypertensive Retinopathy is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Renin secretion and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drug Carbon monoxide has been mentioned in the context of this disorder. Affiliated tissues include retina, eye and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Hypertensive retinopathy is damage to the retina and retinal circulation due to high blood pressure... more...

Related Diseases for Hypertensive Retinopathy

Diseases related to Hypertensive Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 426)
# Related Disease Score Top Affiliating Genes
1 retinal vascular disease 30.6 VEGFA REN ALB ACE
2 macular retinal edema 30.5 VEGFA ALB ACE
3 neuroretinitis 30.5 CRP ACE
4 renovascular hypertension 30.2 REN AGTR1 ACE
5 malignant hypertension 30.2 VWF REN AGTR1 ADAMTS13 ACE
6 coronary heart disease 1 30.1 CRP ADIPOQ ACE
7 microvascular complications of diabetes 5 30.1 VEGFA ALB AGTR1 ACE
8 pyelonephritis 30.1 CRP ALB ACE
9 urinary tract infection 30.1 CRP ACE
10 eclampsia 30.1 VEGFA REN ALB ACE
11 papilledema 30.1 VEGFA CRP ALB ACE
12 optic nerve disease 30.1 VEGFA CRP ALB
13 arteriolosclerosis 30.0 REN ALB ADIPOQ
14 pheochromocytoma 30.0 VEGFA REN CRP ADIPOQ ACE
15 severe pre-eclampsia 29.9 VEGFA ALB ADIPOQ
16 alport syndrome 29.9 VEGFA ALB ACE
17 homocysteinemia 29.8 VWF CRP ALB
18 antiphospholipid syndrome 29.8 VWF CRP ADAMTS13
19 hyperuricemia 29.8 REN CRP ALB
20 cardiac tamponade 29.6 REN CRP ALB ACE
21 chronic pyelonephritis 29.6 REN CRP ALB ACE
22 urinary tract obstruction 29.6 REN CRP ALB ACE
23 microvascular complications of diabetes 3 29.5 REN ALB AGTR1 ACE
24 hypertensive nephropathy 29.5 VEGFA ALB AGTR1 ACE
25 proteinuria, chronic benign 29.4 VEGFA REN ALB AGTR1 ACE
26 vascular disease 29.3 VWF VEGFA REN CRP ALB ADIPOQ
27 hydronephrosis 29.3 VWF VEGFA REN CRP ALB
28 renal hypertension 29.1 REN NR3C2 ALB AGTR1 ACE
29 acute cystitis 29.0 REN NR3C2 CRP ALB ACE
30 hypertensive encephalopathy 28.9 VEGFA REN ALB AGTR1 ADAMTS13 ACE
31 pre-eclampsia 28.8 VWF VEGFA REN CRP ALB AGTR1
32 arteries, anomalies of 28.8 VEGFA REN CRP ALB AGTR1 ADIPOQ
33 systemic lupus erythematosus 28.8 VWF VEGFA CRP ALB ADIPOQ ADAMTS13
34 cerebrovascular disease 28.7 VWF REN CRP AGTR1 ADIPOQ ADAMTS13
35 atherosclerosis susceptibility 28.6 VWF VEGFA CRP ALB AGTR1 ADIPOQ
36 lipoprotein quantitative trait locus 28.6 VWF VEGFA REN CRP ALB AGTR1
37 kidney disease 28.4 VEGFA REN NR3C2 CRP ALB AGTR1
38 hypertension, essential 28.4 VWF VEGFA REN NR3C2 CRP ALB
39 chronic kidney disease 28.3 VEGFA REN NR3C2 CRP ALB AGTR1
40 congestive heart failure 28.1 VEGFA REN NR3C2 CRP ALB AGTR1
41 myocardial infarction 27.4 VWF VEGFA REN NR3C2 CRP ALB
42 renal artery obstruction 10.4 REN ACE
43 hypoaldosteronism 10.4 REN ACE
44 hypertension, diastolic 10.3 REN ACE
45 glomerular disease 10.3 ALB ACE
46 intrahepatic gall duct cancer 10.3 ALB ADIPOQ
47 colorectal cancer 5 10.3 VWF ADAMTS13
48 potter's syndrome 10.3 REN ACE
49 perinephritis 10.3 REN ACE
50 pediatric angiosarcoma 10.3 VWF VEGFA

Comorbidity relations with Hypertensive Retinopathy via Phenotypic Disease Network (PDN):


Deficiency Anemia Hypertension, Essential
Malignant Essential Hypertension

Graphical network of the top 20 diseases related to Hypertensive Retinopathy:



Diseases related to Hypertensive Retinopathy

Symptoms & Phenotypes for Hypertensive Retinopathy

GenomeRNAi Phenotypes related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.5 ADAMTS13
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-123 9.5 ADAMTS13 GPR174
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.5 GPR174
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.5 NR3C2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-151 9.5 ADAMTS13
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.5 ADAMTS13
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 9.5 GPR174
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-185 9.5 NR3C2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.5 NR3C2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-2 9.5 GPR174
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.5 NR3C2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 9.5 ADAMTS13
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-70 9.5 NR3C2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.5 AGTR1

MGI Mouse Phenotypes related to Hypertensive Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ACE ADIPOQ AGTR1 ALB CRP FTH1
2 hematopoietic system MP:0005397 10.02 ACE ADAMTS13 ADIPOQ AGTR1 FTH1 GPR174
3 homeostasis/metabolism MP:0005376 10 ACE ADAMTS13 ADIPOQ AGTR1 ALB CRP
4 immune system MP:0005387 9.93 ACE ADAMTS13 ADIPOQ AGTR1 ALB CRP
5 mortality/aging MP:0010768 9.7 ACE ADAMTS13 ADIPOQ AGTR1 ALB FTH1
6 renal/urinary system MP:0005367 9.17 ACE ADIPOQ AGTR1 ALB NR3C2 REN

Drugs & Therapeutics for Hypertensive Retinopathy

Drugs for Hypertensive Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbon monoxide Approved, Investigational 630-08-0 281

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Classification of Retinal Diseases by Artificial Intelligence Completed NCT04678375
2 Brain Integrity in Survivors of Hodgkin Lymphoma (HL) Treated With Thoracic Radiation Completed NCT01820117
3 Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy Recruiting NCT01753648
4 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in the Imaging of Retinovascular Disease Terminated NCT01717937

Search NIH Clinical Center for Hypertensive Retinopathy

Cochrane evidence based reviews: hypertensive retinopathy

Genetic Tests for Hypertensive Retinopathy

Anatomical Context for Hypertensive Retinopathy

MalaCards organs/tissues related to Hypertensive Retinopathy:

40
Retina, Eye, Kidney, Endothelial, Heart, Brain, Spinal Cord

Publications for Hypertensive Retinopathy

Articles related to Hypertensive Retinopathy:

(show top 50) (show all 658)
# Title Authors PMID Year
1
[Non-arteritic ischaemic optic neuropathy as a target organ lesion in arterial hypertension]. 61
33036924 2021
2
Could aortic arch calcification help in detection of hypertensive retinopathy? 61
33234808 2021
3
Ocular manifestations in hemodialysis patients and short-term changes in ophthalmologic findings. 61
32400088 2021
4
Ocular manifestations in renal allograft recipients: An Indian perspective. 61
33727456 2021
5
Association between Hyperhomocysteinemia and Hypertensive Retinopathy in a Chinese Han Population. 61
33660574 2021
6
Morphological changes in and quantitative analysis of macular retinal microvasculature by optical coherence tomography angiography in hypertensive retinopathy. 61
33311576 2021
7
The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy. 61
33750864 2021
8
Cough headache as a presenting feature of posterior reversible encephalopathy syndrome (PRES). 61
33762394 2021
9
Effect of advanced nursing care on psychological disorder in hypertensive retinopathy of pregnancy: A protocol of systematic review. 61
33578514 2021
10
Dysregulation of miR-637 is involved in the development of retinopathy in hypertension patients and serves a regulatory role in retinol endothelial cell proliferation. 61
33530086 2021
11
Hyperhomocysteinemia: a trigger for complement-mediated TMA? 61
31401947 2021
12
Immunoglobulin A Nephropathy with Erythrocytosis: An Unusual Association. 61
33763321 2021
13
COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? 61
32729633 2021
14
Retinal Microvascular Changes in Hypertensive Patients with Different Levels of Blood Pressure Control and without Hypertensive Retinopathy. 61
32498561 2021
15
The effect of hemodialysis on individual retinal layer thickness. 61
33389423 2021
16
Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography. 61
33470280 2020
17
Can ocular OCT findings be as a predictor for end-organ damage in systemic hypertension? 61
32579082 2020
18
Retinal blood vessel segmentation from fundus image using an efficient multiscale directional representation technique Bendlets. 61
33378918 2020
19
Laquinimod exerts anti-inflammatory and antiapoptotic effects in retinal ischemia/reperfusion injury. 61
33182069 2020
20
Nonmydriatic Retinal Diabetic Screening in the Primary Care Setting: Assessing Degree of Retinopathy and Incidence of Nondiabetic Ocular Diagnoses. 61
32083513 2020
21
Positive relationship of hypertensive retinopathy with carotid intima--media thickness in hypertensive patients. 61
32890279 2020
22
Hypertensive retinopathy in a neonate. 61
33127728 2020
23
Hypertension, retinopathy, and acute kidney injury in dogs: A prospective study. 61
32677736 2020
24
Non-diabetic Renal Diseases in Patients with Diabetes Mellitus Clinicopathological Correlation. 61
33707815 2020
25
Why Miss the Chance? Incidental Findings while Telescreening for Diabetic Retinopathy. 61
31958252 2020
26
Increased rate of any retinopathy risk in patients with masked hypertension. 61
31856594 2020
27
Diagnosis of chronic stage of hypertensive retinopathy based on spectral domain optical coherence tomography. 61
32618435 2020
28
Positive relationship of hypertensive retinopathy with carotid intima--media thickness in hypertensive patients. 61
32649624 2020
29
Retinal Neurovascular Impairment in Patients with Essential Hypertension: An Optical Coherence Tomography Angiography Study. 61
32725211 2020
30
Deep Learning-Based Detection of Pigment Signs for Analysis and Diagnosis of Retinitis Pigmentosa. 61
32570943 2020
31
[Reliability of retinography for the detection of hypertensive retinopathy in Primary Care]. 61
31694763 2020
32
Subclinical retinal microvascular alterations assessed by optical coherence tomography angiography in children with systemic hypertension. 61
32479999 2020
33
Role of multifocal electroretinogram in assessment of early retinal dysfunction in hypertensive patients. 61
32530770 2020
34
Use of optical coherence tomography angiography for assessment of microvascular changes in the macula and optic nerve head in hypertensive patients without hypertensive retinopathy. 61
31874131 2020
35
Prevalence of Retinal Diseases and Associated Risk Factors in an African Population From Mwanza, Tanzania. 61
32484897 2020
36
Clinical value of multiorgan damage in hypertensive crises: A prospective follow-up study. 61
32271999 2020
37
Data on fundus images for vessels segmentation, detection of hypertensive retinopathy, diabetic retinopathy and papilledema. 61
32154339 2020
38
Preeclampsia as predisposing factor for hypertensive retinopathy: Participation by the RAAS and angiogenic factors. 61
32088240 2020
39
Hypertensive retinopathy and choroidopathy. 61
32392526 2020
40
Retinal Vascular Signs and Cerebrovascular Diseases. 61
31977663 2020
41
Resolution of grade IV hypertensive retinopathy in an adult with pheochromocytoma: post-tumor resection. 61
32060107 2020
42
Pattern of vitreo-retinal diseases at the national referral hospital in Bhutan: a retrospective, hospital-based study. 61
32054472 2020
43
GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling. 61
31918274 2020
44
Ablation of Immunoproteasome β5i Subunit Suppresses Hypertensive Retinopathy by Blocking ATRAP Degradation in Mice. 61
31636038 2020
45
VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND TARGET ORGAN DAMAGE IN RURAL DWELLERS WITH UNCOMPLICATED ARTERIAL HYPERTENSION. 61
33577474 2020
46
A Review of Hypertensive Retinopathy and Chorioretinopathy. 61
32440245 2020
47
[Ophthalmic aspects of vascular and functional changes in malignant arterial hypertension of renal origin]. 61
32880158 2020
48
Phaeochromocytoma of the urinary bladder presenting with malignant hypertension and hypertensive retinopathy. 61
31970077 2020
49
Hypertensive Retinopathy Secondary to Anlotinib Treatment. 61
32581802 2020
50
Profile of retinal diseases in adult patients attending two major eye clinics in Kinshasa, the Democratic Republic of Congo. 61
33078118 2020

Variations for Hypertensive Retinopathy

Expression for Hypertensive Retinopathy

Search GEO for disease gene expression data for Hypertensive Retinopathy.

Pathways for Hypertensive Retinopathy

Pathways related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 REN AGTR1 ACE
2
Show member pathways
10.83 REN NR3C2 AGTR1 ACE

GO Terms for Hypertensive Retinopathy

Cellular components related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 VWF VEGFA REN CRP ALB ADIPOQ
2 platelet alpha granule lumen GO:0031093 9.33 VWF VEGFA ALB
3 extracellular region GO:0005576 9.28 VWF VEGFA REN FTH1 CRP ALB

Biological processes related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.63 VWF VEGFA ALB
2 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.51 VEGFA AGTR1
3 regulation of blood vessel diameter GO:0097746 9.49 AGTR1 ACE
4 regulation of vasoconstriction GO:0019229 9.48 AGTR1 ACE
5 peptide catabolic process GO:0043171 9.43 ADAMTS13 ACE
6 amyloid-beta metabolic process GO:0050435 9.4 REN ACE
7 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.37 CRP ADIPOQ
8 angiotensin maturation GO:0002003 9.32 REN ACE
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.26 AGTR1 ACE
10 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.16 VEGFA ACE
11 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 REN AGTR1
12 kidney development GO:0001822 8.92 VEGFA REN AGTR1 ACE

Molecular functions related to Hypertensive Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.13 REN ADAMTS13 ACE
2 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Hypertensive Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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