MCID: HYP076
MIFTS: 53

Hyperthyroidism

Categories: Cardiovascular diseases, Endocrine diseases, Genetic diseases, Immune diseases, Nephrological diseases, Rare diseases
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Aliases & Classifications for Hyperthyroidism

MalaCards integrated aliases for Hyperthyroidism:

Name: Hyperthyroidism 11 75 28 53 5 41 43 14 16 71
Overactive Thyroid 11 63

Classifications:



External Ids:

Disease Ontology 11 DOID:7998
MeSH 43 D006980
SNOMED-CT 68 190239004
ICD10 31 E05.9
UMLS 71 C0020550 C3714618

Summaries for Hyperthyroidism

MedlinePlus: 41 What is hyperthyroidism? Hyperthyroidism, or overactive thyroid, happens when your thyroid gland makes more thyroid hormones than your body needs. Your thyroid is a small, butterfly-shaped gland in the front of your neck. It makes hormones that control the way the body uses energy. These hormones affect nearly every organ in your body and control many of your body's most important functions. For example, they affect your breathing, heart rate, weight, digestion, and moods. If not treated, hyperthyroidism can cause serious problems with your heart, bones, muscles, menstrual cycle, and fertility. But there are treatments that can help. What causes hyperthyroidism? Hyperthyroidism has several causes. They include: Graves' disease, an autoimmune disorder in which your immune system attacks your thyroid and causes it to make too much hormone. This is the most common cause. Thyroid nodules, which are growths on your thyroid. They are usually benign (not cancer). But they may become overactive and make too much thyroid hormone. Thyroid nodules are more common in older adults. Thyroiditis, inflammation of the thyroid. It causes stored thyroid hormone to leak out of your thyroid gland. Too much iodine. Iodine is found in some medicines, cough syrups, seaweed and seaweed-based supplements. Taking too much of them can cause your thyroid to make too much thyroid hormone. Too much thyroid medicine. This can happen if people who take thyroid hormone medicine for hypothyroidism (underactive thyroid) take too much of it. Who is at risk for hyperthyroidism? You are at higher risk for hyperthyroidism if you: Are a woman Are older than age 60 Have been pregnant or had a baby within the past 6 months Have had thyroid surgery or a thyroid problem, such as goiter Have a family history of thyroid disease Have pernicious anemia, in which the body cannot make enough healthy red blood cells because it does not have enough vitamin B12 Have type 1 diabetes or primary adrenal insufficiency, a hormonal disorder Get too much iodine, from eating large amounts of foods containing iodine or using iodine-containing medicines or supplements What are the symptoms of hyperthyroidism? The symptoms of hyperthyroidism can vary from person to person and may include: Nervousness or irritability Fatigue Muscle weakness Trouble tolerating heat Trouble sleeping Tremor, usually in your hands Rapid and irregular heartbeat Frequent bowel movements or diarrhea Weight loss Mood swings Goiter, an enlarged thyroid that may cause your neck to look swollen. Sometimes it can cause trouble with breathing or swallowing. Adults over age 60 may have different symptoms than younger adults. For example, they may lose their appetite or withdraw from other people. Sometimes this can be mistaken for depression or dementia. What other problems can hyperthyroidism cause? If hyperthyroidism isn't treated, it can cause some serious health problems, including: An irregular heartbeat that can lead to blood clots, stroke, heart failure, and other heart problems An eye disease called Graves' ophthalmopathy. It can cause double vision, light sensitivity, and eye pain. In rare cases, it can lead to vision loss. Thinning bones and osteoporosis Fertility problems in women Complications in pregnancy, such as premature birth, low birth weight, high blood pressure in pregnancy, and miscarriage How is hyperthyroidism diagnosed? Your health care provider may use many tools to make a diagnosis: A medical history, including asking about symptoms A physical exam Thyroid tests, such as TSH, T3, T4, and thyroid antibody blood tests Imaging tests, such as a thyroid scan, ultrasound, or radioactive iodine uptake test. A radioactive iodine uptake test measures how much radioactive iodine your thyroid takes up from your blood after you swallow a small amount of it. What are the treatments for hyperthyroidism? The treatments for hyperthyroidism include medicines, radioiodine therapy, and thyroid surgery: Medicines for hyperthyroidism include Antithyroid medicines, which cause your thyroid to make less thyroid hormone. You probably need to take the medicines for 1 to 2 years. In some cases, you might need to take the medicines for several years. This is the simplest treatment, but it is often not a permanent cure. Beta blocker medicines, which can reduce symptoms such as tremors, rapid heartbeat, and nervousness. They work quickly and can help you feel better until other treatments take effect. Radioiodine therapy is a common and effective treatment for hyperthyroidism. It involves taking radioactive iodine by mouth as a capsule or liquid. This slowly destroys the cells of the thyroid gland that produce thyroid hormone. It does not affect other body tissues. Almost everyone who has radioactive iodine treatment later develops hypothyroidism. This is because the thyroid hormone-producing cells have been destroyed. But hypothyroidism is easier to treat and causes fewer long-term health problems than hyperthyroidism. Surgery to remove part or most of the thyroid gland is done in rare cases. It might be an option for people with large goiters or pregnant women who cannot take antithyroid medicines. If you have all of your thyroid removed, you will need to take thyroid medicines for the rest of your life. Some people who have part of their thyroid removed also need to take medicines. If you have hyperthyroidism, it's important not to get too much iodine. Talk to your health care provider about which foods, supplements, and medicines you need to avoid. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary: Hyperthyroidism, also known as overactive thyroid, is related to graves disease 1 and graves' disease. An important gene associated with Hyperthyroidism is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Peptide hormone metabolism and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Propranolol and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and eye, and related phenotypes are Increased HPV16-GFP infection and homeostasis/metabolism

PubMed Health : 63 Overactive thyroid: The thyroid gland is a part of the body’s endocrine (hormone) system – which is made up of the glands that help regulate many of the body’s different functions. If the thyroid gland is overactive, it produces too much of the thyroid hormone thyroxine. An overactive thyroid (medical term: hyperthyroidism) can be caused by various things. The most common cause is a condition known as Graves disease. The higher levels of thyroid hormones unnecessarily speed up a lot of functions in the body. This can lead to noticeable symptoms such as weight loss, sweating, nervousness or a rapid heartbeat. An overactive thyroid increases the risk of cardiovascular disease (problems affecting the heart and/or blood vessels). If the thyroid gland doesn’t produce enough hormones, the body’s functions slow down. This problem is known as an underactive thyroid or hypothyroidism.

Disease Ontology: 11 A thyroid gland disease that involves an over production of thyroid hormone.

Wikipedia: 75 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormones by the... more...

Related Diseases for Hyperthyroidism

Diseases in the Hyperthyroidism family:

Familial Hyperthyroidism Due to Mutations in Tsh Receptor Rare Hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1158)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 33.0 TSHR TRH TPO THRB TG SHBG
2 graves' disease 32.8 TSHR TPO THRB TG SERPINA7 GNAS
3 thyroid hormone resistance, selective pituitary 32.6 TRH THRB TG SST SERPINA7
4 toxic diffuse goiter 32.2 TSHR TPO TG
5 myxedema 32.1 TSHR TPO TG SERPINA7 INS CTLA4
6 mccune-albright syndrome 32.0 SST PRL LEP GNAS GH1
7 hypothyroidism, congenital, nongoitrous, 1 32.0 TSHR TG GNAS
8 tsh producing pituitary tumor 31.9 THRB SST PRL
9 pituitary tumors 31.8 SST PRL GNAS GH1
10 hashimoto thyroiditis 31.8 TSHR TPO TG SERPINA7 SDHA CTLA4
11 nodular goiter 31.6 TSHR TPO TG CTLA4
12 plummer's disease 31.5 TSHR TPO TG SHBG SERPINA7
13 thyroid crisis 31.5 TSHR TPO TG SERPINA7
14 multinodular goiter 31.5 TSHR TRH TPO TG GNAS
15 thyroiditis 31.4 TSHR TPO TG SERPINA7 PRL INS
16 nontoxic goiter 31.3 TSHR TPO TG SHBG SERPINA7 BGLAP
17 goiter 31.3 TSHR TRH TPO THRB TG SST
18 neonatal thyrotoxicosis 31.3 TSHR THRB TG
19 subacute thyroiditis 31.2 TSHR TPO TG SERPINA7
20 hypothyroidism 31.2 TSHR TRH TPO THRB TG SST
21 graves ophthalmopathy 31.1 TSHR TG SDHA CTLA4
22 thyroid gland follicular carcinoma 31.1 TSHR TPO THRB TG
23 hypoparathyroidism 31.1 TPO INS GNAS CTLA4 BGLAP
24 goiter, multinodular 1, with or without sertoli-leydig cell tumors 31.1 TPO TG
25 adenoma 31.1 TSHR TRH TG SST PRL GNAS
26 thyroid cancer, nonmedullary, 2 31.0 TSHR THRB TG
27 autoimmune disease 31.0 TSHR TPO TG PRTN3 INS CTLA4
28 primary hyperparathyroidism 30.9 PRL GH1 BGLAP
29 hyperthyroxinemia 30.9 TSHR TPO THRB SERPINA7
30 hypoadrenocorticism, familial 30.9 TPO TG CTLA4
31 papillary carcinoma 30.9 TSHR TPO TG GNAS
32 parathyroid adenoma 30.8 TG PRL GNAS
33 pituitary adenoma 30.8 TRH SST PRL GNAS GHRL GH1
34 prediabetes syndrome 30.8 SHBG LEP INS GHRL GH1
35 leptin deficiency or dysfunction 30.8 TRH LEP INS GHRL
36 thyroid gland cancer 30.8 TSHR TPO TG SST
37 gynecomastia 30.7 SHBG PRL LEP CGA
38 endemic goiter 30.7 TSHR TRH TPO TG SERPINA7
39 pre-eclampsia 30.7 SHBG LEP INS CTLA4 CGA
40 postsurgical hypothyroidism 30.7 TSHR TPO TG
41 vitiligo-associated multiple autoimmune disease susceptibility 1 30.6 TPO TG CTLA4
42 deficiency anemia 30.6 PRTN3 LEP INS GNAS GHRL GH1
43 functioning pituitary adenoma 30.6 TRH SST PRL GNAS GH1
44 peptic ulcer disease 30.6 SST INS GHRL
45 pernicious anemia 30.6 TPO TG SST INS
46 chronic kidney disease 30.6 LEP INS GHRL BGLAP
47 fibrous dysplasia 30.6 SST PRL GNAS GH1 BGLAP
48 chromophobe adenoma 30.5 TRH PRL GH1
49 congenital hypothyroidism 30.5 TSHR TRH TPO THRB TG SHBG
50 kidney disease 30.5 PRTN3 LEP INS GNAS GHRL BGLAP

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to Hyperthyroidism

Symptoms & Phenotypes for Hyperthyroidism

GenomeRNAi Phenotypes related to Hyperthyroidism according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HPV16-GFP infection GR00350-A 8.62 SDHA SERPINA7

MGI Mouse Phenotypes related to Hyperthyroidism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 BGLAP CGA CTLA4 GH1 GHRL GNAS
2 nervous system MP:0003631 10.17 CGA GH1 GNAS INS LEP PRL
3 endocrine/exocrine gland MP:0005379 10.17 BGLAP CGA CTLA4 GH1 GHRL GNAS
4 adipose tissue MP:0005375 10.01 BGLAP GH1 GHRL GNAS INS LEP
5 no phenotypic analysis MP:0003012 10 GNAS INS PRTN3 SERPINA6 SST THRB
6 behavior/neurological MP:0005386 10 GH1 GHRL GNAS INS LEP PRL
7 digestive/alimentary MP:0005381 9.91 CTLA4 GHRL GNAS INS LEP SST
8 immune system MP:0005387 9.8 BGLAP CTLA4 GH1 GNAS INS LEP
9 skeleton MP:0005390 9.4 BGLAP CTLA4 GNAS INS LEP SDHA

Drugs & Therapeutics for Hyperthyroidism

PubMed Health treatment related to Hyperthyroidism: 63

Mild hyperthyroidism sometimes gets better on its own, without treatment . But the overproduction of thyroid hormones is usually first stopped using tablets called anti-thyroid drugs. In Graves disease , long-term treatment with this medication can make the thyroid function return to normal. If that doesn’t happen, the thyroid gland is surgically removed or treated with radioactive iodine . Known as radioiodine therapy , this involves swallowing radioactive iodine which is then absorbed by your thyroid gland, where it destroys overactive cells . If the overactive thyroid is caused by an enlarged thyroid gland with “autonomous” cells , the thyroid gland that has been “slowed down” with anti-thyroid drugs is usually surgically removed. If surgery isn’t possible or the thyroid gland isn’t greatly enlarged, radioiodine therapy tends to be more suitable.

Drugs for Hyperthyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4 318-98-9, 525-66-6 62882 4946
2
Lithium carbonate Approved Phase 4 554-13-2
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Cadexomer iodine Experimental Phase 4 94820-09-4
5 Adrenergic beta-Antagonists Phase 4
6 Adrenergic Antagonists Phase 4
7 Neurotransmitter Agents Phase 4
8 Adrenergic Agents Phase 4
9 Anti-Arrhythmia Agents Phase 4
10 Antihypertensive Agents Phase 4
11 Vasodilator Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13 Lugol's solution Phase 4
14
Propylthiouracil Approved, Investigational Phase 3 51-52-5 657298
15
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
16
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
17
Prednisolone Approved, Vet_approved Phase 3 50-24-8 4894 5755
18
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5 1875
19
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 4159 6741
20
(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium Experimental Phase 3 461-06-3
21
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7 4897
22 Antineoplastic Agents, Hormonal Phase 3
23 Anti-Inflammatory Agents Phase 3
24 Antimetabolites Phase 3
25 Insulin, Globin Zinc Phase 3
26
Insulin Phase 3
27
Epoetin Alfa Phase 3
28 Anesthetics Phase 3
29 Anti-Infective Agents, Local Phase 3
30 Hemostatics Phase 3
31 Coagulants Phase 3
32 glucocorticoids Phase 3
33
Methylprednisolone Acetate Phase 3 584547
34
Oxytetracycline Approved, Investigational, Vet_approved Phase 1, Phase 2 79-57-2 54715139 54675779
35
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
36 Anti-Infective Agents Phase 2
37 Anti-Bacterial Agents Phase 2
38 Antiprotozoal Agents Phase 2
39 Antiparasitic Agents Phase 2
40 Antimalarials Phase 2
41
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239
42 Protein Kinase Inhibitors Phase 1
43
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn 14838-15-4, 492-39-7 131954576 4786 26934
44
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
45
Parathyroid hormone Approved, Investigational 9002-64-6
46
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
47
Selenium Approved, Investigational, Vet_approved 7783-07-5, 7782-49-2 533
48
Povidone-iodine Approved 25655-41-8
49
Povidone K30 Approved, Experimental, Withdrawn 9003-39-8 6917 131751496
50
Lutetium Lu 177 dotatate Approved, Investigational 437608-50-9 76966897

Interventional clinical trials:

(show top 50) (show all 78)
# Name Status NCT ID Phase Drugs
1 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Pregnancy Unknown status NCT01779817 Phase 4
2 A Randomized Controlled Clinical Trial on the Effectiveness of Lithium in Comparison to Carbimazole as a Bridging Therapy Prior to Radioactive Iodine for Hyperthyroidism Completed NCT05512715 Phase 4
3 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
4 Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism Completed NCT03393728 Phase 4 Propanolol
5 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
6 Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy Completed NCT03379181 Phase 4 Propranolol
7 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
8 Randomized Clinical Trial, Blinded for the Researcher and Multicenter, to Evaluate the Efficacy and Safety of Preoperative Preparation With Lugol Solution in Euthyroid Patients With Graves-Basedow Disease. Recruiting NCT03980132 Phase 4 Lugols Strong Iodine
9 A Multi-center, Open Label, Randomised Parallel- Group Study to Compare the Efficacy of Cholestyramine Plus Standard Treatment Versus Prednisolone Plus Standard Treatment Versus Standard Treatment Alone in Treatment of Overt Hyperthyroidism Unknown status NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
10 Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis: Review on the Pathway of Insulin Resistance, Lipid, Inflammation, and Endothelial Dysfunction to Pulse Wave Velocity and Carotid Intima-Media Thickness Completed NCT05118542 Phase 3 Propylthiouracil;Methimazole
11 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism: A Clinical Trial With Historical Control Completed NCT01039818 Phase 3
12 Early Administration of L-carnitine in Hemodialysis Patients: Double Blind Randomized Trial Versus Placebo Completed NCT00322322 Phase 3 L-Carnitine
13 Ultrasound-guided Radiofrequency Ablation Versus Radioactive Iodine as Treatment for Hyperthyroidism Caused by Solitary Autonomous Thyroid Nodules Recruiting NCT05142904 Phase 3 Radioactive iodine
14 Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter Recruiting NCT04856488 Phase 3 Iodine-Potassium Iodide 5%-10% Oral and Topical Solution
15 A Phase III, Randomized, Controlled, Open Label, no Profit, Single-center Intervention Study to Compare the Effect of a Conservative (Antithyroid Drugs) and an Ablative Approach (Radioiodine or Total Thyroidectomy) for the Treatment of Hyperthyroidism in Patients With Graves' Disease and Moderate-to-severe and Active Graves' Orbitopathy (GO) Treated With Intravenous Glucocorticoids (ABLAGO Study) Not yet recruiting NCT04776993 Phase 3 Methimazole
16 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy: a Prospective, Uncontrolled Pilot Study Completed NCT01727973 Phase 1, Phase 2 Doxycycline
17 The Effect of Subantimicrobial Dose Doxycycline in Mild Thyroid-Associated Ophthalmopathy Recruiting NCT02203682 Phase 2 Doxycycline hyclate;Placebo
18 An Open-label Study in Healthy Male Subjects to Assess the Effect of Hyperthyroidism Mimicked by Oral Dosing of Levothyroxine on the Pharmacokinetics of Sorafenib Completed NCT02332031 Phase 1 Sorafenib (Nexavar, BAY43-9006);Levothyroxine
19 Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma Completed NCT04346901 Phase 1 Thiamazol
20 Comparison of Standardized Update Value Using Single-photo Emission Computed Tomography and Computed Tomography Between Grave's Disease (Hyperthyroidism) Patients and Normal Humans Unknown status NCT02772705
21 Subclinical Hyperthyroidism "To Treat or Not to Treat?" A Dutch Multicenter Trial Unknown status NCT00151723
22 GRAves Selenium Supplementation Trial (GRASS) - an Investigator-initiated Randomised, Blinded, Multicentre Clinical Trial of Selenium Supplementation Versus Placebo in Patients With Graves' Hyperthyroidism Unknown status NCT01611896
23 Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism Unknown status NCT02812888 thionamide treatment for 3 months
24 A Parallel, Double-blind, Randomized Controlled Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt Unknown status NCT03444246
25 Identification and Regulation of Brown Adipose Tissue (BAT) in Humans. Implications for Energy Expenditure in Humans and in the Treatment of Obesity and Related Metabolic Diseases Unknown status NCT02133040
26 Effect of Radioactive Iodine on Eradication of Helicobacter Pylori in Patients Treated for Thyroid Diseases Unknown status NCT00822289
27 Efficacy Of Non Invasive Diagnostic Procedures In Evaluating The Influence Of Maternal Autoimmune Thyroid Gland Disease On Fetus Unknown status NCT02017080
28 Treatment of M.Graves With Radioactive Iodine: Follow-up Study Unknown status NCT00525122
29 Making Accurate Problem Lists in the EHR Unknown status NCT01105923
30 NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation. A Correlation Study Unknown status NCT01145040
31 Study on the Relationship Between the Thyroid Hormones and the Activity of Brown Adipose Tissue in Human Unknown status NCT01376648
32 The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism Unknown status NCT03434067
33 Localization of Parathyroid Adenoma by Fluorocholine Positron Emission Tomography/MRI (PET/MRI): A Prospective Pilot Study Unknown status NCT02843542
34 Prevention of Iodinated Contrast Media Induced Hyperthyroidism in Patients With Euthyroid Goiter Completed NCT04304794 Prophylactic administration of antithyroid drugs before iodinated contrast media exposure
35 Thyroid Disorders in Malaysian: A Nationwide Multicentre Study Completed NCT02190214
36 Efficacy of Thiamine Supplement for Improve Cardiovascular Function in Patients With Severe Hyperthyroidism Completed NCT02767245 Thiamine
37 Low Doses of Cholestyramine in the Treatment of Hyperthyroidism Completed NCT00677469 Cholestyramine;Placebo powder
38 Randomized Open Clinical Study to Evaluate the Efficacy of Selenium Plus Methimazole for Treatment of Graves' Hyperthyroidism Completed NCT02727738 Methimazole
39 Effectiveness of Classical Potassium Iodide Therapy for the Treatment of Untreated Patients With Graves' Hyperthyroidism, Avoiding Thionamide Drugs With Serious Side Effects of Agranulocytosis, Liver Injury, Vasculitis, Embryopathy or Frequent Side Effects of Skin Eruption Completed NCT04686006 Potassium Iodide
40 Study of the Efficacy and Safety on the Ultrasonic Ablation Treatment for Secondary Hyperthyroidism in Chronic Kidney Disease Patients. Completed NCT01640184 Active vitamin D
41 Postoperative Hyperthyroidism After Parathyroidectomy Completed NCT01095341
42 Morbidity and Mortality Associated With the Care Journey in Children and Adolescents With Hyperthyroidism Completed NCT03951532
43 The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter Completed NCT01384786
44 Observational Prospective Case-control Study on Prevalence and Impact of Subclinical Hyperthyroidism in Patients Undergoing Atrial Fibrillation Ablation Completed NCT01789541
45 Shared Decision Making in Graves Disease - Graves Disease (GD) Choice Completed NCT02107794
46 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Completed NCT02005250
47 Quantitative Analysis of 99mTc-Pertechnetate Thyroid Uptake With a Large Field CZT Gamma Camera: Feasibility and Comparison Between SPECT/CT and Planar Acquisitions Completed NCT05049551
48 Metabolomics of Thyroid Hormones Completed NCT03823859
49 Evaluation of the Effectivity of Teleconsultations for Improving the Referrals From Primary Care to Specialized Care of Patients With Chronic Endocrinological Conditions Completed NCT02710799
50 Follow-up Study of Hyperthyroid Patients Treated With RAI in 1965-2002: Morbidity in Long-Term Follow-up Completed NCT00471458

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Sodium Iodide
Sodium iodide I123

Cochrane evidence based reviews: hyperthyroidism

Genetic Tests for Hyperthyroidism

Genetic tests related to Hyperthyroidism:

# Genetic test Affiliating Genes
1 Hyperthyroidism 28

Anatomical Context for Hyperthyroidism

Organs/tissues related to Hyperthyroidism:

MalaCards : Thyroid, Heart, Eye, Kidney, Pituitary, Skeletal Muscle, Liver

Publications for Hyperthyroidism

Articles related to Hyperthyroidism:

(show top 50) (show all 21737)
# Title Authors PMID Year
1
Association Between Subclinical Thyroid Dysfunction and Fracture Risk. 62 41
36346629 2022
2
The metabolomics approach revealed a distinctive metabolomics pattern associated with hyperthyroidism treatment. 62 41
36440210 2022
3
Masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism. 62 41
36425466 2022
4
Genetics and phenomics of inherited and sporadic non-autoimmune hyperthyroidism. 53 62
20138963 2010
5
Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients. 53 62
20515734 2010
6
Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism. 53 62
19636218 2010
7
Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred mice. 53 62
20407472 2010
8
Hyperthyroidism caused by a germline activating mutation of the thyrotropin receptor gene: difficulties in diagnosis and therapy. 53 62
20146656 2010
9
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 53 62
20464711 2010
10
Thyrotropin receptor autoantibody measurement following radiometabolic treatment of hyperthyroidism: comparison between different methods. 53 62
20418655 2010
11
Recommendations for investigation of hyperandrogenism. 53 62
20096825 2010
12
I-131 treatment of graves' disease in an unsuspected first trimester pregnancy; the potential for adverse effects on the fetus and a review of the current guidelines for pregnancy screening. 53 62
20300595 2010
13
A clinical retrospective analysis of factors associated with apathetic hyperthyroidism. 53 62
20185967 2010
14
Prevalence of paraneoplastic hyperthyroidism in patients with metastatic non-seminomatous germ-cell tumors. 53 62
19605510 2010
15
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 53 62
19914592 2009
16
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 53 62
19762181 2009
17
Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic Islet cell recipients with pretransplant TPO autoantibodies. 53 62
19549735 2009
18
Current insights into the pathogenesis of Graves' orbitopathy. 53 62
19530272 2009
19
[31-year-old male patient with testicular mass and hyperthyroidism]. 53 62
19219417 2009
20
The use of plasmapheresis for rapid hormonal control in severe hyperthyroidism caused by a partial molar pregnancy. 53 62
18726107 2009
21
Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease. 53 62
19066298 2009
22
[Thyroid-stimulating hormone receptor antibodies in the diagnosis of Graves' disease in children]. 53 62
19388481 2009
23
A somatic gain-of-function mutation in the thyrotropin receptor gene producing a toxic adenoma in an infant. 53 62
19191749 2009
24
Ghrelin response to oral glucose load in hyperthyroidism, before and after treatment with antithyroid drugs. 53 62
19411802 2009
25
[Thyroid disorders during pregnancy]. 53 62
19142837 2009
26
Pituitary-hormone secretion by thyrotropinomas. 53 62
19051037 2009
27
First automated assay for thyrotropin receptor autoantibodies. 53 62
19634982 2009
28
[Analysis of serum levels of ghrelin and obestatin in children and adolescents with autoimmune thyroid diseases]. 53 62
19454185 2009
29
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. 53 62
18669595 2008
30
Implications of new monoclonal antibodies and the crystal structure of the TSH receptor for the treatment and management of thyroid diseases. 53 62
20477447 2008
31
Evaluation of a new rapid and fully automated electrochemiluminescence immunoassay for thyrotropin receptor autoantibodies. 53 62
19014323 2008
32
A family with a novel TSH receptor activating germline mutation (p.Ala485Val). 53 62
18175146 2008
33
Serum concentrations of adiponectin and resistin in hyperthyroid Graves' disease patients. 53 62
18997483 2008
34
Peripheral blood T lymphocyte sensitisation against calsequestrin and flavoprotein in patients with Graves' ophthalmopathy. 53 62
18568642 2008
35
Serum ghrelin levels are increased in hypothyroid patients and become normalized by L-thyroxine treatment. 53 62
18381578 2008
36
Multiple relapses of hyperthyroidism after thyroid surgeries in a patient with long term follow-up of sporadic non-autoimmune hyperthyroidism. 53 62
18528812 2008
37
Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. 53 62
18466078 2008
38
A new silent germline mutation of the TSH receptor: coexpression in a hyperthyroid family member with a second activating somatic mutation. 53 62
18466076 2008
39
Thyroid storm caused by a partial hydatidiform mole. 53 62
18352822 2008
40
Selenium analogues of antithyroid drugs--recent developments. 53 62
18357551 2008
41
A novel TSHR gene mutation (Ile691Phe) in a Chinese family causing autosomal dominant non-autoimmune hyperthyroidism. 53 62
18306976 2008
42
A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism. 53 62
18025759 2007
43
The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. 53 62
17823263 2007
44
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 53 62
17887926 2007
45
Pediatric thyroid testing issues. 53 62
18167471 2007
46
Low TSH levels are not associated with osteoporosis in childhood. 53 62
17656602 2007
47
Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. 53 62
17588648 2007
48
A new case of familial nonautoimmune hyperthyroidism caused by the M463V mutation in the TSH receptor with anticipation of the disease across generations: a possible role of iodine supplementation. 53 62
17696839 2007
49
Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases. 53 62
17389703 2007
50
Human chorionic gonadotropin-induced hyperthyroidism in germ cell cancer--a case presentation and review of the literature. 53 62
17585415 2007

Variations for Hyperthyroidism

Expression for Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

GO Terms for Hyperthyroidism

Cellular components related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.07 BGLAP CGA GH1 GHRL INS LEP
2 extracellular region GO:0005576 9.78 BGLAP CGA GH1 GHRL GNAS INS
3 endosome lumen GO:0031904 9.63 PRL INS GH1

Biological processes related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell population proliferation GO:0008284 10.14 TSHR PRTN3 PRL LEP INS CGA
2 glucose metabolic process GO:0006006 9.91 LEP INS GHRL
3 positive regulation of cold-induced thermogenesis GO:0120162 9.86 GHRL GNAS LEP TSHR
4 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.85 PRL LEP GH1
5 positive regulation of multicellular organism growth GO:0040018 9.72 TSHR GHRL GH1
6 thyroid hormone generation GO:0006590 9.63 TPO TG CGA
7 response to nutrient levels GO:0031667 9.5 PRL LEP GHRL GH1 BGLAP
8 hormone-mediated signaling pathway GO:0009755 9.32 TSHR TRH THRB GHRL CGA

Molecular functions related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.53 TRH TG SST PRL LEP INS
2 prolactin receptor binding GO:0005148 9.26 PRL GH1

Sources for Hyperthyroidism

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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