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MCID: HYP076
MIFTS: 56

Hyperthyroidism

Categories: Endocrine diseases, Rare diseases, Immune diseases, Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Hyperthyroidism

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MalaCards integrated aliases for Hyperthyroidism:

Name: Hyperthyroidism 12 76 37 29 55 6 43 44 15 73
Overactive Thyroid 12 63

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Endocrine diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:7998
ICD10 33 E05.9
MeSH 44 D006980
NCIt 50 C3123
KEGG 37 H01645
UMLS 73 C0020550
Sources

Summaries for Hyperthyroidism

About this section
MedlinePlus : 43 Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism. If your thyroid is too active, it makes more thyroid hormones than your body needs. This is called hyperthyroidism. Hyperthyroidism is more common in women, people with other thyroid problems, and those over 60 years old. Graves' disease, an autoimmune disorder, is the most common cause. Other causes include thyroid nodules, thyroiditis, consuming too much iodine, and taking too much synthetic thyroid hormone. The symptoms can vary from person to person. They may include Being nervous or irritable Mood swings Fatigue or muscle weakness Heat intolerance Trouble sleeping Hand tremors Rapid and irregular heartbeat Frequent bowel movements or diarrhea Weight loss Goiter, which is an enlarged thyroid that may cause the neck to look swollen To diagnose hyperthyroidism, your doctor will do a physical exam, look at your symptoms, and do thyroid tests. Treatment is with medicines, radioiodine therapy, or thyroid surgery. No single treatment works for everyone. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hyperthyroidism, also known as overactive thyroid, is related to myxedema and struma ovarii. An important gene associated with Hyperthyroidism is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Peptide ligand-binding receptors and Aldosterone synthesis and secretion. The drugs Hyaluronic acid and Propylthiouracil have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and heart, and related phenotypes are Decreased HPV16-GFP infection and endocrine/exocrine gland

Disease Ontology : 12 A thyroid gland disease that involves an over production of thyroid hormone.

PubMed Health : 63 About overactive thyroid: The thyroid gland is a part of the body’s endocrine (hormone) system – which is made up of the glands that help regulate many of the body’s different functions. If the thyroid gland is overactive, it produces too much of the thyroid hormone thyroxine. An overactive thyroid (medical term: hyperthyroidism) can be caused by various things. The most common cause is a condition known as Graves disease.The higher levels of thyroid hormones unnecessarily speed up a lot of functions in the body. This can lead to noticeable symptoms such as weight loss, sweating, nervousness or a rapid heartbeat. An overactive thyroid increases the risk of cardiovascular disease (problems affecting the heart and/or blood vessels).If the thyroid gland doesn’t produce enough hormones, the body’s functions slow down. This problem is known as an underactive thyroid or hypothyroidism.

Wikipedia : 76 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the... more...

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Related Diseases for Hyperthyroidism

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Diseases in the Hyperthyroidism family:

Familial Hyperthyroidism Due to Mutations in Tsh Receptor

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 myxedema 32.6 CTLA4 TG TPO TSHR
2 struma ovarii 32.6 TG TSHR
3 graves' disease 32.3 CTLA4 LMOD1 SERPINA7 TG THRB TPO
4 graves disease 1 32.1 SERPINA7 TG THRB TPO TRH TSHR
5 plummer's disease 31.5 SHBG TG THRB TPO
6 nodular goiter 31.3 TG TPO TSHR
7 pituitary tumors 31.1 GH1 GNAS PRL SST
8 neonatal hypothyroidism 31.0 TG TPO TSHR
9 mccune-albright syndrome 30.9 BGLAP GH1 GNAS PRL SST
10 multinodular goiter 30.9 GNAS TG TPO TSHR
11 congenital hypothyroidism 30.6 TG TPO TSHR
12 benign struma ovarii 30.5 TG TSHR
13 exophthalmos 30.5 PRL TG TSHR
14 thyroiditis 30.4 CTLA4 SERPINA7 TG THRB TPO TRH
15 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.4 TG TPO
16 papillary carcinoma 30.2 TG TPO TSHR
17 pernicious anemia 30.1 SST TG TPO
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 CTLA4 TG TPO TSHR
19 endemic goiter 30.0 SERPINA7 TG TPO TSHR
20 differentiated thyroid carcinoma 29.9 BGLAP TG TPO TSHR
21 subacute thyroiditis 29.9 SERPINA6 SERPINA7 SHBG TG TPO TSHR
22 celiac disease 1 29.7 CTLA4 GHRL TG TPO
23 hypoadrenalism 29.7 GH1 SHBG TG
24 thyroid cancer 29.7 GNAS SST TG THRB TPO TSHR
25 glucose intolerance 29.7 GHRL LEP SHBG
26 hyperthyroxinemia 29.7 SERPINA7 TPO TRH TSHR
27 thyroid hormone resistance, generalized, autosomal dominant 29.7 SERPINA7 SHBG TG THRB TRH
28 goiter 29.4 BGLAP GNAS SERPINA7 TG THRB TPO
29 gynecomastia 29.4 CGA PRL SHBG
30 prolactin producing pituitary tumor 29.3 PRL SST
31 adenoma 29.3 GH1 GNAS PRL SST TSHR
32 chromophobe adenoma 29.2 GH1 PRL SERPINA7 TRH
33 nontoxic goiter 29.1 BGLAP SERPINA7 SHBG TG TPO TSHR
34 amenorrhea 29.1 LEP PRL SHBG TRH
35 thyroid cancer, nonmedullary, 2 28.9 LMOD1 SST TG THRB TPO TSHR
36 hyperpituitarism 28.6 GH1 PRL SST TRH
37 anorexia nervosa 28.5 GH1 GHRL LEP PRL
38 insulin-like growth factor i 28.5 BGLAP GH1 LEP PRL SHBG
39 craniopharyngioma 28.5 GH1 GHRL PRL TRH
40 fibrous dysplasia 28.4 BGLAP GH1 GNAS PRL SST
41 hypothyroidism 28.3 CTLA4 GH1 GNAS LEP PRL SERPINA7
42 diabetes mellitus, noninsulin-dependent 28.3 GH1 GHRL LEP SHBG SST
43 hyperprolactinemia 28.0 GH1 PRL SHBG SST TRH
44 acromegaly 27.5 GH1 GHRL GNAS PRL SST TRH
45 adrenal gland hyperfunction 27.0 BGLAP GH1 GHRL LEP PRL SERPINA6
46 hyperthyroidism, familial gestational 12.5
47 hyperthyroidism, nonautoimmune 12.4
48 familial hyperthyroidism due to mutations in tsh receptor 12.2
49 congenital craniosynostosis maternal hyperthyroiditis 11.9
50 thyroid hormone resistance, selective pituitary 11.7

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to Hyperthyroidism
Sources

Symptoms & Phenotypes for Hyperthyroidism

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GenomeRNAi Phenotypes related to Hyperthyroidism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.92 GNAS SDHA SERPINA7 TRH

MGI Mouse Phenotypes related to Hyperthyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.9 PRL TG THRB TPO CGA TRH
2 homeostasis/metabolism MP:0005376 9.8 LEP PRL SDHA SERPINA6 SST TG
3 immune system MP:0005387 9.32 LEP PRL PRTN3 SERPINA6 SST THRB
Sources

Drugs & Therapeutics for Hyperthyroidism

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PubMedHealth treatment related to Hyperthyroidism: 63

Mild hyperthyroidism sometimes gets better on its own, without treatment. But the overproduction of thyroid hormones is usually first stopped using tablets called anti-thyroid drugs. In Graves disease, long-term treatment with this medication can make the thyroid function return to normal. If that doesn’t happen, the thyroid gland is surgically removed or treated with radioactive iodine. Known as radioiodine therapy, this involves swallowing radioactive iodine which is then absorbed by your thyroid gland, where it destroys overactive cells.If the overactive thyroid is caused by an enlarged thyroid gland with “autonomous” cells, the thyroid gland that has been “slowed down” with anti-thyroid drugs is usually surgically removed. If surgery isn’t possible or the thyroid gland isn’t greatly enlarged, radioiodine therapy tends to be more suitable.

Drugs for Hyperthyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 230)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
2
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
3
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
4
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7553-56-2 807
5
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
7
Propranolol Approved, Investigational Phase 4,Phase 3,Not Applicable 525-66-6 4946
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
9
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
10
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
11
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
12
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
13
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
14
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
15
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
17
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
18
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
19
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
20
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
21
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 134070 5280453
22
leucovorin Approved, Nutraceutical Phase 4,Not Applicable 58-05-9 143 6006
23
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
24
Alfacalcidol Approved, Nutraceutical Phase 4,Phase 2 41294-56-8 5282181
25
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 59-30-3 6037
27
Dinoprost Investigational Phase 4 551-11-1 5283078
28 triamcinolone acetonide Phase 4,Not Applicable
29 cadexomer iodine Phase 4,Phase 2,Phase 3,Not Applicable
30 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
31 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 abobotulinumtoxinA Phase 4,Phase 2,Phase 3
33 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
34 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
35 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3,Not Applicable
36 Adjuvants, Immunologic Phase 4,Not Applicable
37 Adrenergic Agents Phase 4,Phase 3,Phase 2
38 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Adrenergic Antagonists Phase 4,Phase 3
40 Adrenergic beta-Antagonists Phase 4,Phase 3
41 Cholinergic Agents Phase 4,Phase 2,Phase 3
42 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Neuromuscular Agents Phase 4,Phase 2,Phase 3
44 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
45 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Not Applicable
46 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
47 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
50 onabotulinumtoxinA Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 201)
# Name Status NCT ID Phase Drugs
1 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
2 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
3 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
4 Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol Completed NCT03393728 Phase 4 Propanolol
5 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
6 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
7 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
8 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
9 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
10 Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis Completed NCT01181531 Phase 4 Traditional Vitamin D Therapy;Cinacalcet
11 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
12 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
13 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
14 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
15 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
16 Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy Recruiting NCT03379181 Phase 4 Propranolol
17 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy Recruiting NCT01779817 Phase 4
18 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
19 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
20 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
21 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
22 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
23 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
24 Early Levothyroxine Post Radioactive Iodine Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
25 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
26 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
27 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
28 Early Administration of L-carnitine in Hemodialysis Patients Completed NCT00322322 Phase 3 L-Carnitine
29 Low Salt Diet in Idiopathic Hypercalciuria Completed NCT01005082 Phase 2, Phase 3
30 Percutaneous Radiofrequency Thermal Ablation in Compressive Thyroid Nodules Completed NCT01649206 Phase 3
31 Antithyroid Drug Treatment of Thyrotoxicosis in Young People Completed NCT01436994 Phase 3 carbimazole;propylthiouracil;thyroxine
32 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
33 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
34 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
35 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
36 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
37 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Recruiting NCT03298867 Phase 3
38 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
39 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
40 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
41 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
42 Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study Enrolling by invitation NCT03461211 Phase 3
43 Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) Not yet recruiting NCT03486873 Phase 3 Standard of Care (SOC)
44 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
45 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
46 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
47 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
48 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
49 LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin Completed NCT00593047 Phase 2 KB2115
50 Eprotirome for the Treatment of Dyslipidemia, Efficacy and Safety 12-Week, Phase ii Study to Assess the Safety and Efficacy of KB2115 in Patients With Primary Hypercholesterolemia Completed NCT00776321 Phase 2 Eprotirome;Placebo

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: hyperthyroidism

Sources

Genetic Tests for Hyperthyroidism

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Genetic tests related to Hyperthyroidism:

# Genetic test Affiliating Genes
1 Hyperthyroidism 29
Sources

Anatomical Context for Hyperthyroidism

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MalaCards organs/tissues related to Hyperthyroidism:

41
Thyroid, Eye, Heart, Bone, Testes, Kidney, Pituitary
Sources

Publications for Hyperthyroidism

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Articles related to Hyperthyroidism:

(show top 50) (show all 1267)
# Title Authors Year
1
Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis. ( 29336235 )
2018
2
Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies. ( 29340156 )
2018
3
A Case Report of Dilated Biventricular Heart Failure from Hyperthyroidism: A Rare Presentation. ( 29872591 )
2018
4
Does hyperthyroidism worsen prognosis of thyroid carcinoma? A retrospective analysis on 2820 consecutive thyroidectomies. ( 29357932 )
2018
5
Apparent Hyperthyroidism Caused by Biotin-Like Interference from IgM Anti-Streptavidin Antibodies. ( 29808739 )
2018
6
Transient Hyperthyroidism Induced by Thyroid Ultrasound. ( 29911397 )
2018
7
Does initial dosing of levothyroxine in infants with congenital hypothyroidism lead to frequent dose adjustments secondary to iatrogenic hyperthyroidism on follow-up? ( 29715192 )
2018
8
Epidemiology of childhood hyperthyroidism in France: a nationwide population-based study. ( 29846622 )
2018
9
Association of Hyperthyroidism and Thyroid Autoantibodies with Moyamoya Disease and Its Stroke Event: A Population-based Case-control Study and Meta-analysis. ( 29353860 )
2018
10
Association between Circulating Irisin Levels and Epicardial Fat in Patients with Treatment-NaA^ve Overt Hyperthyroidism. ( 29862847 )
2018
11
Differential effects of experimental hyperthyroidism on declined immunity of broiler chicken. ( 29327786 )
2018
12
A Rare Case of Thyrolipomatosis Presenting with Latent Hyperthyroidism. ( 29962723 )
2018
13
A Case of Heart Failure with Hyperthyroidism Demonstrating Discrepancy between the Clinical Course and B-type Natriuretic Peptide Levels. ( 29434126 )
2018
14
Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases. ( 29406821 )
2018
15
Evaluation of Serum Symmetric Dimethylarginine Concentration as a Marker for Masked Chronic Kidney Disease in Cats With Hyperthyroidism. ( 29377360 )
2018
16
Nonthionamide Drugs for the Treatment of Hyperthyroidism: From Present to Future. ( 29849619 )
2018
17
Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism. ( 29805818 )
2018
18
High-dose biotin in infants mimics biochemical hyperthyroidism with some commercial assays. ( 29314108 )
2018
19
Energy Metabolism in the Bone is Associated with Histomorphometric Changes in Rats with Hyperthyroidism. ( 29689555 )
2018
20
Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies. ( 29872340 )
2018
21
Subclinical Hyperthyroidism. ( 29924956 )
2018
22
De novo SOX10 Nonsense Mutation in a Patient with Kallmann Syndrome, Deafness, Iris Hypopigmentation, and Hyperthyroidism. ( 29678855 )
2018
23
Effects of the dopamine D<sub>3</sub>receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model. ( 29369372 )
2018
24
A patient-specific treatment model for Graves' hyperthyroidism. ( 29310665 )
2018
25
Clinicopathological features and comorbidities of cats with mild, moderate or severe hyperthyroidism: a radioiodine referral population. ( 29432704 )
2018
26
Symptomatic hyperthyroidism in metastatic testicular mixed germ cell tumour. ( 29884717 )
2018
27
Formation of lamellar bodies in rat liver mitochondria in hyperthyroidism. ( 29721776 )
2018
28
Prevalence and risk factors for hyperthyroidism in Irish cats from the greater Dublin area. ( 29372047 )
2018
29
An update in the treatment preference for hyperthyroidism. ( 29773870 )
2018
30
Abnormal spontaneous brain activity is associated with impaired emotion and cognition in hyperthyroidism: A rs-fMRI study. ( 29885847 )
2018
31
Clinical management of childhood hyperthyroidism with and without Down syndrome: a longitudinal study at a single center. ( 29953411 )
2018
32
Cardiovascular morbidity and mortality after treatment of hyperthyroidism with either radioactive iodine or thyroidectomy. ( 29882483 )
2018
33
Narcolepsy with cataplexy and hyperthyroidism sudden appeared after H1N1 vaccination. ( 29796199 )
2018
34
Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats. ( 29405728 )
2018
35
Adult-Onset Sleepwalking Secondary to Hyperthyroidism: Polygraphic Evidence. ( 29246269 )
2018
36
Selenium in Graves Hyperthyroidism and Orbitopathy. ( 29933354 )
2018
37
The Effect of Experimental Hyperthyroidism on Characteristics of Actin-Myosin Interaction in Fast and Slow Skeletal Muscles. ( 29738686 )
2018
38
Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study. ( 29198022 )
2018
39
The effect of short-term treatment with lithium carbonate on the outcome of radioiodine therapy in patients with long-lasting Graves' hyperthyroidism. ( 28895066 )
2017
40
Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice. ( 29273081 )
2017
41
MOK, a pharmacopuncture medicine, regulates thyroid dysfunction in L-thyroxin-induced hyperthyroidism in rats through the regulation of oxidation and the TRPV1 ion channel. ( 29246135 )
2017
42
Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. ( 28195550 )
2017
43
Atrial fibrillation and hyperthyroidism: A literature review. ( 28822529 )
2017
44
Effects of electromagnetic fields on bone loss in hyperthyroidism rat model. ( 27973686 )
2017
45
Recurrent Graves' hyperthyroidism after prolonged radioiodine-induced hypothyroidism. ( 28944001 )
2017
46
Clinical efficacy of Yingliu mixture combined with metimazole for treating diffuse goitre with hyperthyroidism and its impact on related cytokines. ( 27927064 )
2017
47
ST-segment elevation acute myocardial infarction associated with hyperthyroidism: beware of coronary spasm! ( 28858949 )
2017
48
Changes in Resting-State Cerebral Activity in Patients with Hyperthyroidism: A Short-Term Follow-Up Functional MR Imaging Study. ( 28878279 )
2017
49
Prevalence of and risk factors for feline hyperthyroidism in South Africa. ( 28826266 )
2017
50
Dyschromatosis symmetrica hereditaria with cutaneous lupus erythematosus and hyperthyroidism. ( 28496371 )
2017
Sources

Variations for Hyperthyroidism

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ClinVar genetic disease variations for Hyperthyroidism:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;X;t(X;3)(p21.3;p25.1)dn Translocation Pathogenic
Sources

Expression for Hyperthyroidism

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Search GEO for disease gene expression data for Hyperthyroidism.
Sources

Pathways for Hyperthyroidism

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Pathways related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 12.92 CGA GH1 GHRL GNAS LEP PRL
2
Aldosterone synthesis and secretion 37
Show member pathways
 12.71 CGA GNAS SERPINA7 TG TPO TSHR
3
Allograft rejection 1 37
Show member pathways
 12.63 CGA CTLA4 TG TPO TSHR
4
Prolactin Signaling Pathway 1 37
Show member pathways
 12.23 CGA GH1 LEP PRL
5
Peptide hormone metabolism 66
Show member pathways
 11.88 CGA GH1 GHRL LEP
6
Glucocorticoid receptor regulatory network 1
11.52 BGLAP CGA PRL
7
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.41 CGA GNAS TSHR
8
Regulation of lipolysis in adipocytes 37
11.17 CGA GNAS TSHR
9
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.99 BGLAP CGA THRB
10
Hormone ligand-binding receptors 66
10.57 CGA TSHR
11
Thyroxine (Thyroid Hormone) Production 1
9.8 CGA TG TPO TRH TSHR
Sources

GO Terms for Hyperthyroidism

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Cellular components related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 BGLAP GH1 GHRL LEP PRL PRTN3
2 extracellular region GO:0005576 9.47 BGLAP CGA GH1 GHRL GNAS LEP
3 endosome lumen GO:0031904 9.16 GH1 PRL

Biological processes related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.89 CGA LEP PRL PRTN3 TSHR
2 cell-cell signaling GO:0007267 9.87 CGA SST TRH TSHR
3 response to ethanol GO:0045471 9.73 BGLAP LEP TRH
4 female pregnancy GO:0007565 9.69 GNAS LEP PRL
5 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.55 GNAS TSHR
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.54 GH1 PRL
7 positive regulation of multicellular organism growth GO:0040018 9.54 GH1 GHRL TSHR
8 energy reserve metabolic process GO:0006112 9.52 GNAS LEP
9 thyroid gland development GO:0030878 9.5 CGA TG THRB
10 thyroid hormone generation GO:0006590 9.48 CGA TPO
11 hormone biosynthetic process GO:0042446 9.46 TG TPO
12 hormone-mediated signaling pathway GO:0009755 9.46 GHRL THRB TRH TSHR
13 positive regulation of growth GO:0045927 9.43 GH1 GHRL
14 positive regulation of JAK-STAT cascade GO:0046427 9.43 GH1 LEP PRL
15 adult feeding behavior GO:0008343 9.4 GHRL LEP
16 response to nutrient levels GO:0031667 9.35 BGLAP GH1 GHRL LEP PRL
17 regulation of signaling receptor activity GO:0010469 9.23 CGA GH1 GHRL LEP PRL SST

Molecular functions related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 CGA GH1 GHRL LEP PRL SST
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL
Sources

Sources for Hyperthyroidism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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