MCID: HYP076
MIFTS: 53

Hyperthyroidism

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Hyperthyroidism

MalaCards integrated aliases for Hyperthyroidism:

Name: Hyperthyroidism 12 73 36 29 54 6 42 44 15 17 70
Overactive Thyroid 12 62

Classifications:



External Ids:

Disease Ontology 12 DOID:7998
KEGG 36 H01645
MeSH 44 D006980
NCIt 50 C3123
SNOMED-CT 67 190239004
ICD10 32 E05.9
UMLS 70 C0020550

Summaries for Hyperthyroidism

MedlinePlus : 42 What is hyperthyroidism? Hyperthyroidism, or overactive thyroid, happens when your thyroid gland makes more thyroid hormones than your body needs. Your thyroid is a small, butterfly-shaped gland in the front of your neck. It makes hormones that control the way the body uses energy. These hormones affect nearly every organ in your body and control many of your body's most important functions. For example, they affect your breathing, heart rate, weight, digestion, and moods. If not treated, hyperthyroidism can cause serious problems with your heart, bones, muscles, menstrual cycle, and fertility. But there are treatments that can help. What causes hyperthyroidism? Hyperthyroidism has several causes. They include Grave's disease, an autoimmune disorder in which your immune system attacks your thyroid and causes it to make too much hormone. This is the most common cause. Thyroid nodules, which are growths on your thyroid. They are usually benign (not cancer). But they may become overactive and make too much thyroid hormone. Thyroid nodules are more common in older adults. Thyroiditis, inflammation of the thyroid. It causes stored thyroid hormone to leak out of your thyroid gland. Too much iodine. Iodine is found in some medicines, cough syrups, seaweed and seaweed-based supplements. Taking too much of them can cause your thyroid to make too much thyroid hormone. Too much thyroid medicine. This can happen if people who take thyroid hormone medicine for hypothyroidism (underactive thyroid) take too much of it. Who is at risk for hyperthyroidism? You are at higher risk for hyperthyroidism if you Are a woman Are older than age 60 Have been pregnant or had a baby within the past 6 months Have had thyroid surgery or a thyroid problem, such as goiter Have a family history of thyroid disease Have pernicious anemia, in which the body cannot make enough healthy red blood cells because it does not have enough vitamin B12 Have type 1 diabetes or primary adrenal insufficiency, a hormonal disorder Get too much iodine, from eating large amounts of foods containing iodine or using iodine-containing medicines or supplements What are the symptoms of hyperthyroidism? The symptoms of hyperthyroidism can vary from person to person and may include Nervousness or irritability Fatigue Muscle weakness Trouble tolerating heat Trouble sleeping Tremor, usually in your hands Rapid and irregular heartbeat Frequent bowel movements or diarrhea Weight loss Mood swings Goiter, an enlarged thyroid that may cause your neck to look swollen. Sometimes it can cause trouble with breathing or swallowing. Adults over age 60 may have different symptoms than younger adults. For example, they may lose their appetite or withdraw from other people. Sometimes this can be mistaken for depression or dementia. What other problems can hyperthyroidism cause? If hyperthyroidism isn't treated, it can cause some serious health problems, including An irregular heartbeat that can lead to blood clots, stroke, heart failure, and other heart problems An eye disease called Graves' ophthalmopathy. It can cause double vision, light sensitivity, and eye pain. In rare cases, it can lead to vision loss. Thinning bones and osteoporosis Fertility problems in women Complications in pregnancy, such as premature birth, low birth weight, high blood pressure in pregnancy, and miscarriage How is hyperthyroidism diagnosed? To make a diagnosis, your health care provider Will take your medical history, including asking about symptoms Will do a physical exam May do thyroid tests, such as TSH, T3, T4, and thyroid antibody blood tests Imaging tests, such as a thyroid scan, ultrasound, or radioactive iodine uptake test. A radioactive iodine uptake test measures how much radioactive iodine your thyroid takes up from your blood after you swallow a small amount of it. What are the treatments for hyperthyroidism? The treatments for hyperthyroidism include medicines, radioiodine therapy, and thyroid surgery: Medicines for hyperthyroidism include Antithyroid medicines, which cause your thyroid to make less thyroid hormone. You probably need to take the medicines for 1 to 2 years. In some cases, you might need to take the medicines for several years. This is the simplest treatment, but it is often not a permanent cure. Beta blocker medicines, which can reduce symptoms such as tremors, rapid heartbeat, and nervousness. They work quickly and can help you feel better until other treatments take effect. Radioiodine therapy is a common and effective treatment for hyperthyroidism. It involves taking radioactive iodine by mouth as a capsule or liquid. This slowly destroys the cells of the thyroid gland that produce thyroid hormone. It does not affect other body tissues. Almost everyone who has radioactive iodine treatment later develops hypothyroidism. This is because the thyroid hormone-producing cells have been destroyed. But hypothyroidism is easier to treat and causes fewer long-term health problems than hyperthyroidism. Surgery to remove part or most of the thyroid gland is done in rare cases. It might be an option for people with large goiters or pregnant women who cannot take antithyroid medicines. If you have all of your thyroid removed, you will need to take thyroid medicines for the rest of your life. Some people who have part of their thyroid removed also need to take medicines. If you have hyperthyroidism, it's important not to get too much iodine. Talk to your health care provider about which foods, supplements, and medicines you need to avoid. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hyperthyroidism, also known as overactive thyroid, is related to hyperthyroidism, nonautoimmune and graves' disease. An important gene associated with Hyperthyroidism is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Peptide ligand-binding receptors and Allograft rejection. The drugs Propranolol and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and eye, and related phenotypes are Decreased HPV16-GFP infection and behavior/neurological

Disease Ontology : 12 A thyroid gland disease that involves an over production of thyroid hormone.

KEGG : 36 Hyperthyroidism is a pathological disorder characterised by increased thyroid hormone synthesis and secretion from the thyroid gland. The term thyrotoxicosis is not synonymous with hyperthyroidism. Thyrotoxicosis is defined as the clinical syndrome of hypermetabolism resulting from increased thyroid hormone levels, irrespective of the source. The causes of hyperthyroidism include Graves' disease, toxic multinodular goiter, and solitary toxic adenoma. Less common causes of hyperthyroidism include thyrotropin-induced thyrotoxicosis and trophoblastic tumours. The causes of thyrotoxicosis without hyperthyroidism are less common and generally transient. In patients with silent thyroiditis, post-partum thyroiditis, or subacute painful thyroiditis, the destruction of thyrocytes leads to release of preformed hormones into the circulation. Drug-induced thyrotoxicosis has the same pathogenic mechanism as thyroiditis. Exogenous thyrotoxicosis develops after ingestion of excessive amounts of thyroid hormone, and is associated with low serum thyroglobulin concentrations. Patients of hyperthyroidism/thyrotoxicosis usually have fatigue, nervousness or anxiety, weight loss, palpitations, and heat sensitivity. Clinical findings almost always include tachycardia, warm moist skin, the presence of an enlarged thyroid, and a slight tremor. The three options for treating patients with hyperthyroidism are antithyroid drugs (ATDs), radioactive iodine ablation, and surgery. All three therapeutic options would be effective in the treatment of patients with Graves' disease, whereas patients with toxic adenoma or toxic multinodular goiter should have either radioactive iodine therapy or surgery, since these patients rarely go into remission. In patients with toxic nodular goiter, ATDs are generally used to restore euthyroidism before definitive treatment with surgery or radioactive iodine, and infrequently used as long-term treatment when the other two therapies are contraindicated or the patient has a short life expectancy.

PubMed Health : 62 About overactive thyroid: The thyroid gland is a part of the body’s endocrine (hormone) system – which is made up of the glands that help regulate many of the body’s different functions. If the thyroid gland is overactive, it produces too much of the thyroid hormone thyroxine. An overactive thyroid (medical term: hyperthyroidism) can be caused by various things. The most common cause is a condition known as Graves disease. The higher levels of thyroid hormones unnecessarily speed up a lot of functions in the body. This can lead to noticeable symptoms such as weight loss, sweating, nervousness or a rapid heartbeat. An overactive thyroid increases the risk of cardiovascular disease (problems affecting the heart and/or blood vessels). If the thyroid gland doesn’t produce enough hormones, the body’s functions slow down. This problem is known as an underactive thyroid or hypothyroidism.

Wikipedia : 73 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormones by the... more...

Related Diseases for Hyperthyroidism

Diseases in the Hyperthyroidism family:

Rare Hyperthyroidism

Diseases related to Hyperthyroidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 998)
# Related Disease Score Top Affiliating Genes
1 hyperthyroidism, nonautoimmune 33.3 TSHR CEP128
2 graves' disease 32.7 TSHR TPO THRB TG SERPINA7 GNAS
3 thyroid crisis 32.2 TSHR TPO TG SERPINA7
4 myxedema 32.1 TSHR TPO TG SERPINA7 CTLA4
5 graves disease 1 32.0 TSHR TRH TPO THRB TG SHBG
6 hypoparathyroidism 31.9 TPO INS GNAS CTLA4 BGLAP
7 thyroid carcinoma 31.8 TSHR TPO TG
8 mccune-albright syndrome 31.8 SST PRL GNAS GH1 BGLAP
9 pituitary tumors 31.7 SST PRL GNAS GH1
10 multinodular goiter 31.6 TSHR TPO TG GNAS
11 thyroiditis 31.5 TSHR TPO TG SERPINA7 INS CTLA4
12 nodular goiter 31.5 TSHR TPO TG CTLA4
13 plummer's disease 31.4 TSHR TPO TG SHBG SERPINA7
14 exophthalmos 31.3 TSHR TPO TG PRL
15 goiter 31.2 TSHR TRH TPO THRB TG SST
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 TSHR TPO TG INS CTLA4
17 hashimoto thyroiditis 31.1 TSHR TPO TG SERPINA7 CTLA4
18 bone resorption disease 31.0 LEP INS BGLAP
19 adenoma 30.9 TSHR TRH TG SST PRL GNAS
20 subacute thyroiditis 30.9 TSHR TPO TG SHBG SERPINA7 SERPINA6
21 hypothyroidism 30.8 TSHR TRH TPO THRB TG SST
22 differentiated thyroid carcinoma 30.8 TSHR TPO TG BGLAP
23 papillary carcinoma 30.8 TSHR TPO TG
24 endemic goiter 30.8 TSHR TPO TG SERPINA7
25 autoimmune disease 30.8 TSHR TPO TG PRTN3 INS CTLA4
26 gynecomastia 30.8 SHBG PRL LEP
27 pituitary adenoma 30.8 TRH SST PRL GNAS GH1
28 hyperthyroxinemia 30.7 TSHR TRH TPO THRB SERPINA7
29 postsurgical hypothyroidism 30.7 TPO TG
30 multiple endocrine neoplasia 30.6 TG SST GNAS
31 thyroid gland follicular carcinoma 30.6 TSHR TPO THRB TG SST GNAS
32 primary hyperparathyroidism 30.6 PRL INS BGLAP
33 toxic diffuse goiter 30.5 TSHR TPO TG SERPINA7
34 hypogonadism 30.5 SHBG PRL LEP INS
35 hypoglycemia 30.5 SST PRL INS GH1
36 chromophobe adenoma 30.5 TRH PRL GH1
37 pernicious anemia 30.4 TPO TG SST
38 fibrous dysplasia 30.4 SST PRL GNAS GH1 BGLAP
39 orbital disease 30.4 TSHR TG PRTN3 CTLA4
40 thyroid gland cancer 30.3 TSHR TPO THRB TG SST
41 chronic kidney disease 30.3 LEP INS GNAS GHRL BGLAP
42 nontoxic goiter 30.3 TSHR TPO TG SHBG SERPINA7 BGLAP
43 congenital hypothyroidism 30.3 TSHR TRH TPO TG SHBG SERPINA7
44 hypothyroidism, congenital, nongoitrous, 2 30.3 TSHR TG CEP128
45 anca-associated vasculitis 30.3 PRTN3 CTLA4
46 osteoporosis 30.3 SHBG PRL LEP INS GNAS GHRL
47 hyperinsulinism 30.2 SST SHBG LEP INS GHRL GH1
48 hypothyroidism, congenital, nongoitrous, 1 30.2 TSHR TG GNAS CEP128
49 pituitary hormone deficiency, combined, 2 30.2 TRH PRL GH1
50 hypopituitarism 30.2 TRH SHBG PRL LEP INS GH1

Graphical network of the top 20 diseases related to Hyperthyroidism:



Diseases related to Hyperthyroidism

Symptoms & Phenotypes for Hyperthyroidism

GenomeRNAi Phenotypes related to Hyperthyroidism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.62 GNAS TRH

MGI Mouse Phenotypes related to Hyperthyroidism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 GHRL GNAS INS LEP PRL SERPINA6
2 homeostasis/metabolism MP:0005376 10.13 BGLAP CTLA4 GHRL GNAS INS LEP
3 endocrine/exocrine gland MP:0005379 10.1 BGLAP CTLA4 GHRL GNAS INS LEP
4 adipose tissue MP:0005375 9.98 BGLAP GHRL GNAS INS LEP SST
5 digestive/alimentary MP:0005381 9.97 CTLA4 GHRL INS LEP SST TG
6 immune system MP:0005387 9.97 BGLAP CTLA4 GNAS INS LEP PRL
7 no phenotypic analysis MP:0003012 9.5 GNAS INS PRTN3 SERPINA6 SST THRB
8 skeleton MP:0005390 9.4 BGLAP CTLA4 GNAS INS LEP SDHA

Drugs & Therapeutics for Hyperthyroidism

PubMed Health treatment related to Hyperthyroidism: 62

Mild hyperthyroidism sometimes gets better on its own, without treatment . But the overproduction of thyroid hormones is usually first stopped using tablets called anti-thyroid drugs. In Graves disease , long-term treatment with this medication can make the thyroid function return to normal. If that doesn’t happen, the thyroid gland is surgically removed or treated with radioactive iodine . Known as radioiodine therapy , this involves swallowing radioactive iodine which is then absorbed by your thyroid gland, where it destroys overactive cells . If the overactive thyroid is caused by an enlarged thyroid gland with “autonomous” cells , the thyroid gland that has been “slowed down” with anti-thyroid drugs is usually surgically removed. If surgery isn’t possible or the thyroid gland isn’t greatly enlarged, radioiodine therapy tends to be more suitable.

Drugs for Hyperthyroidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4 525-66-6 4946
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Cadexomer iodine Experimental Phase 4 94820-09-4
4 Vasodilator Agents Phase 4
5 Adrenergic Antagonists Phase 4
6 Anti-Arrhythmia Agents Phase 4
7 Adrenergic beta-Antagonists Phase 4
8 Neurotransmitter Agents Phase 4
9 Adrenergic Agents Phase 4
10 Antihypertensive Agents Phase 4
11 Lugol's solution Phase 4
12 Pharmaceutical Solutions Phase 4
13
Carbimazole Approved, Investigational Phase 3 22232-54-8 31072
14
Methimazole Approved Phase 3 60-56-0 1349907
15
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
17
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
18
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
19
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
20
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
21 Antithyroid Agents Phase 3
22 Antimetabolites Phase 3
23 Cholestyramine Resin Phase 3
24 Lipid Regulating Agents Phase 3
25 Anticholesteremic Agents Phase 3
26 Hypolipidemic Agents Phase 3
27 Antineoplastic Agents, Hormonal Phase 3
28 Anti-Inflammatory Agents Phase 3
29 carnitine Phase 3
30 Epoetin alfa Phase 3 113427-24-0
31 Hormone Antagonists Phase 3
32 Hormones Phase 3
33 glucocorticoids Phase 3
34 Methylprednisolone Acetate Phase 3
35
Oxytetracycline Approved, Investigational, Vet_approved Phase 1, Phase 2 79-57-2 5280972 54715139
36
Doxycycline Approved, Investigational, Vet_approved Phase 1, Phase 2 564-25-0 54671203
37 Anti-Infective Agents Phase 1, Phase 2
38 Antimalarials Phase 1, Phase 2
39 Antiparasitic Agents Phase 1, Phase 2
40 Anti-Bacterial Agents Phase 1, Phase 2
41 Antiprotozoal Agents Phase 1, Phase 2
42
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
43 Protein Kinase Inhibitors Phase 1
44
Propylthiouracil Approved, Investigational 51-52-5 657298
45
Parathyroid hormone Approved, Investigational 9002-64-6
46
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
47
Phenylpropanolamine Approved, Vet_approved, Withdrawn 14838-15-4 26934
48
Selenium Approved, Investigational, Vet_approved 7782-49-2
49
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
50
Thiamine Approved, Investigational, Nutraceutical, Vet_approved 70-16-6, 59-43-8 1130

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Assessment of Intellectual, Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Pregnancy Unknown status NCT01779817 Phase 4
2 Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism Completed NCT03393728 Phase 4 Propanolol
3 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
4 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy Completed NCT03379181 Phase 4 Propranolol
6 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
7 Randomized Clinical Trial, Blinded for the Researcher and Multicenter, to Evaluate the Efficacy and Safety of Preoperative Preparation With Lugol Solution in Euthyroid Patients With Graves-Basedow Disease. Recruiting NCT03980132 Phase 4 Lugols Strong Iodine
8 A Multi-center, Open Label, Randomised Parallel- Group Study to Compare the Efficacy of Cholestyramine Plus Standard Treatment Versus Prednisolone Plus Standard Treatment Versus Standard Treatment Alone in Treatment of Overt Hyperthyroidism Unknown status NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
9 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism: A Clinical Trial With Historical Control Completed NCT01039818 Phase 3
10 Early Administration of L-carnitine in Hemodialysis Patients: Double Blind Randomized Trial Versus Placebo Completed NCT00322322 Phase 3 L-Carnitine
11 A Phase III, Randomized, Controlled, Open Label, no Profit, Single-center Intervention Study to Compare the Effect of a Conservative (Antithyroid Drugs) and an Ablative Approach (Radioiodine or Total Thyroidectomy) for the Treatment of Hyperthyroidism in Patients With Graves' Disease and Moderate-to-severe and Active Graves' Orbitopathy (GO) Treated With Intravenous Glucocorticoids (ABLAGO Study) Not yet recruiting NCT04776993 Phase 3 Methimazole
12 The Effect of Subantimicrobial Dose Doxycycline in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
13 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy: a Prospective, Uncontrolled Pilot Study Completed NCT01727973 Phase 1, Phase 2 Doxycycline
14 Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma Completed NCT04346901 Phase 1 Thiamazol
15 An Open-label Study in Healthy Male Subjects to Assess the Effect of Hyperthyroidism Mimicked by Oral Dosing of Levothyroxine on the Pharmacokinetics of Sorafenib Completed NCT02332031 Phase 1 Sorafenib (Nexavar, BAY43-9006);Levothyroxine
16 The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism Unknown status NCT03434067
17 Treatment of M.Graves With Radioactive Iodine: Follow-up Study Unknown status NCT00525122
18 Localization of Parathyroid Adenoma by Fluorocholine Positron Emission Tomography/MRI (PET/MRI): A Prospective Pilot Study Unknown status NCT02843542
19 A Parallel, Double-blind, Randomized Controlled Trial for the Evaluation of the Treatment and Outcome of Hyperthyroidism With Iodized Salt and Non Iodized Salt Unknown status NCT03444246
20 Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism Unknown status NCT02812888 thionamide treatment for 3 months
21 Comparison of Standardized Update Value Using Single-photo Emission Computed Tomography and Computed Tomography Between Grave's Disease (Hyperthyroidism) Patients and Normal Humans Unknown status NCT02772705
22 Subclinical Hyperthyroidism "To Treat or Not to Treat?" A Dutch Multicenter Trial Unknown status NCT00151723
23 Efficacy Of Non Invasive Diagnostic Procedures In Evaluating The Influence Of Maternal Autoimmune Thyroid Gland Disease On Fetus Unknown status NCT02017080
24 Identification and Regulation of Brown Adipose Tissue (BAT) in Humans. Implications for Energy Expenditure in Humans and in the Treatment of Obesity and Related Metabolic Diseases Unknown status NCT02133040
25 Study on the Relationship Between the Thyroid Hormones and the Activity of Brown Adipose Tissue in Human Unknown status NCT01376648
26 Making Accurate Problem Lists in the EHR Unknown status NCT01105923
27 Effect of Radioactive Iodine on Eradication of Helicobacter Pylori in Patients Treated for Thyroid Diseases Unknown status NCT00822289
28 Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction Completed NCT00437931
29 Postoperative Hyperthyroidism After Parathyroidectomy Completed NCT01095341
30 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Completed NCT02005250
31 Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients Completed NCT01560299 Methimazole;Methimazole;Methimazole
32 Thyroid Function & Breast Cancer: A Pilot Study to Estimate the Prevalence of Thyroid Dysfunction in Women Diagnosed With Breast Cancer and the Magnitude of Change in Thyroid Function Post-Chemotherapy Completed NCT00336102
33 Randomized Controlled Trial of Bipolar Versus Ultrasonic Hemostasis Techniques in Thyroidectomy Completed NCT00524966
34 Brown Adipose Tissue Activity and Thyroid Hormone Completed NCT02499471
35 Effectiveness of Classical Potassium Iodide Therapy for the Treatment of Untreated Patients With Graves' Hyperthyroidism, Avoiding Thionamide Drugs With Serious Side Effects of Agranulocytosis, Liver Injury, Vasculitis, Embryopathy or Frequent Side Effects of Skin Eruption Completed NCT04686006 Potassium Iodide
36 Randomized Open Clinical Study to Evaluate the Efficacy of Selenium Plus Methimazole for Treatment of Graves' Hyperthyroidism Completed NCT02727738 Methimazole
37 Observational Prospective Case-control Study on Prevalence and Impact of Subclinical Hyperthyroidism in Patients Undergoing Atrial Fibrillation Ablation Completed NCT01789541
38 Efficacy of Thiamine Supplement for Improve Cardiovascular Function in Patients With Severe Hyperthyroidism Completed NCT02767245 Thiamine
39 The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter Completed NCT01384786
40 Prevention of Iodinated Contrast Media Induced Hyperthyroidism in Patients With Euthyroid Goiter Completed NCT04304794 Prophylactic administration of antithyroid drugs before iodinated contrast media exposure
41 Study of the Efficacy and Safety on the Ultrasonic Ablation Treatment for Secondary Hyperthyroidism in Chronic Kidney Disease Patients. Completed NCT01640184 Active vitamin D
42 Low Doses of Cholestyramine in the Treatment of Hyperthyroidism Completed NCT00677469 Cholestyramine;Cholestyramine;Placebo powder
43 A Blinded Study Evaluating the Accuracy and Safety of Cyclotron-produced 99mTc in Adult Patients Completed NCT02514187 Cyclotron-produced 99mTc;Generator-produced 99mTc
44 Follow-up Study of Hyperthyroid Patients Treated With RAI in 1965-2002: Morbidity in Long-Term Follow-up Completed NCT00471458
45 Coexisting Thyroid Disease and Hyperparathyroidism Completed NCT01306916
46 Fetal Thyroid Hormones Concentration In Hyperthyroid or Hypothyroid Pregnant Women Completed NCT01528904
47 Hyperthyroid Follow-Up Study Completed NCT02989103
48 Effect of Childhood Radioiodine Therapy on Salivary Function Completed NCT02375451
49 TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases Completed NCT03612908
50 Evaluation of the Effectivity of Teleconsultations for Improving the Referrals From Primary Care to Specialized Care of Patients With Chronic Endocrinological Conditions Completed NCT02710799

Search NIH Clinical Center for Hyperthyroidism

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Sodium Iodide
Sodium iodide I123

Cochrane evidence based reviews: hyperthyroidism

Genetic Tests for Hyperthyroidism

Genetic tests related to Hyperthyroidism:

# Genetic test Affiliating Genes
1 Hyperthyroidism 29

Anatomical Context for Hyperthyroidism

MalaCards organs/tissues related to Hyperthyroidism:

40
Thyroid, Pituitary, Eye, Heart, Bone, Skeletal Muscle, Cortex

Publications for Hyperthyroidism

Articles related to Hyperthyroidism:

(show top 50) (show all 20526)
# Title Authors PMID Year
1
Investigate the improvement of facial skin texture with the VISIA system after total thyroidectomy. 61 42
33612095 2021
2
A Blunted Sympathetic Function and an Enhanced Nitrergic Activity Contribute to Reduce Mesenteric Resistance in Hyperthyroidism. 42 61
33430047 2021
3
Adherence to levothyroxine prescription in patients with hypothyroidism. 42
33480371 2020
4
Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients. 61 54
20515734 2010
5
Genetics and phenomics of inherited and sporadic non-autoimmune hyperthyroidism. 61 54
20138963 2010
6
Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism. 54 61
19636218 2010
7
Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred mice. 61 54
20407472 2010
8
Hyperthyroidism caused by a germline activating mutation of the thyrotropin receptor gene: difficulties in diagnosis and therapy. 54 61
20146656 2010
9
Thyrotropin receptor autoantibody measurement following radiometabolic treatment of hyperthyroidism: comparison between different methods. 54 61
20418655 2010
10
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 61 54
20464711 2010
11
Recommendations for investigation of hyperandrogenism. 61 54
20096825 2010
12
I-131 treatment of graves' disease in an unsuspected first trimester pregnancy; the potential for adverse effects on the fetus and a review of the current guidelines for pregnancy screening. 54 61
20300595 2010
13
A clinical retrospective analysis of factors associated with apathetic hyperthyroidism. 61 54
20185967 2010
14
Prevalence of paraneoplastic hyperthyroidism in patients with metastatic non-seminomatous germ-cell tumors. 61 54
19605510 2010
15
Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes. 54 61
19914592 2009
16
Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic Islet cell recipients with pretransplant TPO autoantibodies. 54 61
19549735 2009
17
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 54 61
19762181 2009
18
[31-year-old male patient with testicular mass and hyperthyroidism]. 54 61
19219417 2009
19
Current insights into the pathogenesis of Graves' orbitopathy. 54 61
19530272 2009
20
The use of plasmapheresis for rapid hormonal control in severe hyperthyroidism caused by a partial molar pregnancy. 54 61
18726107 2009
21
Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease. 54 61
19066298 2009
22
[Thyroid-stimulating hormone receptor antibodies in the diagnosis of Graves' disease in children]. 54 61
19388481 2009
23
A somatic gain-of-function mutation in the thyrotropin receptor gene producing a toxic adenoma in an infant. 61 54
19191749 2009
24
Ghrelin response to oral glucose load in hyperthyroidism, before and after treatment with antithyroid drugs. 54 61
19411802 2009
25
[Thyroid disorders during pregnancy]. 61 54
19142837 2009
26
Pituitary-hormone secretion by thyrotropinomas. 61 54
19051037 2009
27
[Analysis of serum levels of ghrelin and obestatin in children and adolescents with autoimmune thyroid diseases]. 61 54
19454185 2009
28
First automated assay for thyrotropin receptor autoantibodies. 54 61
19634982 2009
29
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. 61 54
18669595 2008
30
Implications of new monoclonal antibodies and the crystal structure of the TSH receptor for the treatment and management of thyroid diseases. 54 61
20477447 2008
31
Evaluation of a new rapid and fully automated electrochemiluminescence immunoassay for thyrotropin receptor autoantibodies. 61 54
19014323 2008
32
A family with a novel TSH receptor activating germline mutation (p.Ala485Val). 54 61
18175146 2008
33
Serum concentrations of adiponectin and resistin in hyperthyroid Graves' disease patients. 54 61
18997483 2008
34
Peripheral blood T lymphocyte sensitisation against calsequestrin and flavoprotein in patients with Graves' ophthalmopathy. 61 54
18568642 2008
35
Serum ghrelin levels are increased in hypothyroid patients and become normalized by L-thyroxine treatment. 61 54
18381578 2008
36
Multiple relapses of hyperthyroidism after thyroid surgeries in a patient with long term follow-up of sporadic non-autoimmune hyperthyroidism. 61 54
18528812 2008
37
A new silent germline mutation of the TSH receptor: coexpression in a hyperthyroid family member with a second activating somatic mutation. 61 54
18466076 2008
38
Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. 54 61
18466078 2008
39
Thyroid storm caused by a partial hydatidiform mole. 61 54
18352822 2008
40
Selenium analogues of antithyroid drugs--recent developments. 54 61
18357551 2008
41
A novel TSHR gene mutation (Ile691Phe) in a Chinese family causing autosomal dominant non-autoimmune hyperthyroidism. 54 61
18306976 2008
42
The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. 61 54
17823263 2007
43
A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism. 54 61
18025759 2007
44
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 61 54
17887926 2007
45
Pediatric thyroid testing issues. 61 54
18167471 2007
46
Low TSH levels are not associated with osteoporosis in childhood. 61 54
17656602 2007
47
Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. 61 54
17588648 2007
48
A new case of familial nonautoimmune hyperthyroidism caused by the M463V mutation in the TSH receptor with anticipation of the disease across generations: a possible role of iodine supplementation. 54 61
17696839 2007
49
Human chorionic gonadotropin-induced hyperthyroidism in germ cell cancer--a case presentation and review of the literature. 61 54
17585415 2007
50
Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases. 54 61
17389703 2007

Variations for Hyperthyroidism

Expression for Hyperthyroidism

Search GEO for disease gene expression data for Hyperthyroidism.

Pathways for Hyperthyroidism

Pathways related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 TSHR TRH THRB SST PRL LEP
2
Show member pathways
12.6 TSHR TPO TG INS CTLA4
3
Show member pathways
12.4 TSHR TPO TG SERPINA7 INS GNAS
4
Show member pathways
12.25 PRL LEP INS GH1
5 12.07 TSHR SST GNAS GHRL
6
Show member pathways
11.93 LEP INS GHRL GH1
7 11.63 LEP INS BGLAP
8 11.34 TSHR INS GNAS
9 11.2 PRL LEP INS
10 10.56 PRL LEP INS GHRL
11 9.7 TSHR TRH TPO TG

GO Terms for Hyperthyroidism

Cellular components related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TPO TG SST SERPINA7 SERPINA6 PRTN3
2 extracellular region GO:0005576 9.47 TRH TG SST SHBG SERPINA7 SERPINA6
3 endosome lumen GO:0031904 9.33 PRL INS GH1

Biological processes related to Hyperthyroidism according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 TSHR PRTN3 PRL LEP INS
2 cell-cell signaling GO:0007267 9.73 TSHR TRH SST INS
3 female pregnancy GO:0007565 9.7 PRL LEP GNAS
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 LEP INS GH1
5 glucose metabolic process GO:0006006 9.58 LEP INS GHRL
6 thyroid hormone generation GO:0006590 9.57 TPO TG
7 energy reserve metabolic process GO:0006112 9.56 LEP GNAS
8 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.55 PRL GH1
9 positive regulation of JAK-STAT cascade GO:0046427 9.5 PRL LEP GH1
10 positive regulation of growth GO:0045927 9.49 GHRL GH1
11 hormone biosynthetic process GO:0042446 9.48 TPO TG
12 adult feeding behavior GO:0008343 9.46 LEP GHRL
13 positive regulation of cold-induced thermogenesis GO:0120162 9.46 TSHR LEP GNAS GHRL
14 positive regulation of multicellular organism growth GO:0040018 9.43 TSHR GHRL GH1
15 negative regulation of feeding behavior GO:2000252 9.37 TRH INS
16 hormone-mediated signaling pathway GO:0009755 9.26 TSHR TRH THRB GHRL
17 response to nutrient levels GO:0031667 9.02 PRL LEP GHRL GH1 BGLAP

Molecular functions related to Hyperthyroidism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 TRH TG SST PRL LEP INS
2 insulin-like growth factor receptor binding GO:0005159 9.16 INS GNAS
3 prolactin receptor binding GO:0005148 8.96 PRL GH1

Sources for Hyperthyroidism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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