MCID: HYP029
MIFTS: 32

Hyperthyroxinemia

Categories: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

MalaCards integrated aliases for Hyperthyroxinemia:

Name: Hyperthyroxinemia 12 54 44 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2855
MeSH 44 D006981
NCIt 50 C131850
UMLS 71 C0020551

Summaries for Hyperthyroxinemia

Disease Ontology : 12 A thyroid gland disease that is characterized by elevated thyroxine levels in the blood.

MalaCards based summary : Hyperthyroxinemia is related to thyroid hormone resistance, generalized, autosomal dominant and amyloidosis, hereditary, transthyretin-related. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include thyroid, pituitary and bone marrow, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 74 Hyperthyroxinemia is a thyroid disease where the serum levels of thyroxine are higher than... more...

Related Diseases for Hyperthyroxinemia

Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 thyroid hormone resistance, generalized, autosomal dominant 30.5 TSHR TRH THRB THRA SERPINA7
2 amyloidosis, hereditary, transthyretin-related 29.8 TTR SERPINA7 ALB
3 polyneuropathy 29.8 TTR SERPINA7 ALB
4 thyroiditis 29.7 TSHR TPO SERPINA7
5 generalized resistance to thyroid hormone 29.7 TRH THRB
6 exophthalmos 29.5 TSHR TPO
7 graves' disease 29.4 TSHR TPO THRB SERPINA7
8 hyperthyroidism 29.3 TSHR TRH TPO THRB SERPINA7 ALB
9 subacute thyroiditis 29.3 TSHR TPO SERPINA7
10 hashimoto thyroiditis 29.2 TSHR TPO SERPINA7
11 goiter 29.2 TSHR TRH TPO THRB SERPINA7
12 multinodular goiter 29.2 TSHR TPO
13 graves disease 1 29.2 TSHR TRH TPO THRB SERPINA7 ALB
14 congenital hypothyroidism 28.7 TSHR TRH TPO THRA SERPINA7 ALB
15 hypothyroidism 27.8 TTR TSHR TRH TPO THRB THRA
16 hyperthyroxinemia, dystransthyretinemic 11.7
17 hyperthyroxinemia, familial dysalbuminemic 11.7
18 hyperthyroxinemia, euthyroid, caused by generalized 5-prime-deiodinase deficiency 11.1
19 thyroid hormone plasma membrane transport defect 11.1
20 marasmus 10.2 TTR ALB
21 kwashiorkor 10.2 TTR ALB
22 koro 10.2 OXA1L ALB
23 mononeuropathy 10.2 TTR ALB
24 decubitus ulcer 10.2 TTR ALB
25 chronic ulcer of skin 10.2 TTR ALB
26 red cell aplasia 10.2 OXA1L ALB
27 pericardium disease 10.2 TTR ALB
28 autonomic nervous system disease 10.2 TTR ALB
29 drug allergy 10.2 OXA1L ALB
30 klebsiella pneumonia 10.2 OXA1L ALB
31 dysentery 10.2 TTR ALB
32 pure red-cell aplasia 10.2 OXA1L ALB
33 protein-energy malnutrition 10.2 TTR ALB
34 acute thyroiditis 10.2 TPO SERPINA7
35 bile acid synthesis defect, congenital, 1 10.1 TTR ALB
36 mixed cerebral palsy 10.1 TTR TRH
37 pericardial effusion 10.1 TTR ALB
38 demyelinating polyneuropathy 10.1 TTR ALB
39 analbuminemia 10.1 TTR OXA1L ALB
40 pituitary adenoma 10.0
41 peripheral resistance to thyroid hormones 10.0
42 acute cystitis 10.0 OXA1L ALB
43 nerve compression syndrome 10.0 TTR ALB
44 obstructive jaundice 10.0 TTR ALB
45 euthyroid sick syndrome 10.0 TRH SERPINA7 ALB
46 bilirubin metabolic disorder 10.0
47 bipolar disorder 10.0
48 adenoma 10.0
49 respiratory failure 9.9 TTR SERPINA7 ALB
50 neonatal thyrotoxicosis 9.9 TSHR THRA

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to Hyperthyroxinemia

Symptoms & Phenotypes for Hyperthyroxinemia

MGI Mouse Phenotypes related to Hyperthyroxinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.65 ALB THRA THRB TRH TTR
2 endocrine/exocrine gland MP:0005379 9.63 ALB THRA THRB TPO TRH TSHR
3 homeostasis/metabolism MP:0005376 9.56 ALB PDE8B THRA THRB TPO TRH
4 renal/urinary system MP:0005367 9.02 ALB PDE8B THRA TRH TTR

Drugs & Therapeutics for Hyperthyroxinemia

Search Clinical Trials , NIH Clinical Center for Hyperthyroxinemia

Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

Anatomical Context for Hyperthyroxinemia

MalaCards organs/tissues related to Hyperthyroxinemia:

40
Thyroid, Pituitary, Bone Marrow, Breast, Ovary

Publications for Hyperthyroxinemia

Articles related to Hyperthyroxinemia:

(show top 50) (show all 318)
# Title Authors PMID Year
1
Resistance to thyroid hormone in a Turkish child with A317T mutation in the thyroid hormone receptor-beta gene. 61 54
19227423 2008
2
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. 54 61
17190692 2006
3
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. 61 54
15068631 2004
4
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. 54 61
11385707 2001
5
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. 54 61
10946882 2000
6
The thyroxine-binding proteins. 54 61
10718550 2000
7
Familial dysalbuminemic byperthyroxinemia may result in altered warfarin pharmacokinetics. 54 61
10728776 2000
8
Adjuvant effects of cholera toxin b subunit on immune response to recombinant thyrotropin receptor in mice. 61 54
10648115 2000
9
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. 61 54
10430791 1999
10
Mutagenesis studies of thyroxine binding to human serum albumin define an important structural characteristic of subdomain 2A. 61 54
9188698 1997
11
Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis. 54 61
9368688 1997
12
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. 54 61
8784093 1996
13
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. 54 61
8702585 1996
14
Measurement of serum free thyroid hormone concentrations: an essential tool for the diagnosis of thyroid dysfunction. 61 54
8964573 1996
15
Familial dysalbuminemic hyperthyroxinemia in pregnancy. 61 54
8548059 1995
16
Expression of a human serum albumin variant with high affinity for thyroxine. 54 61
7575519 1995
17
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. 54 61
7628382 1995
18
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. 54 61
7852505 1995
19
[Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. 61 54
8196175 1994
20
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. 61 54
8288714 1994
21
Thyroxine binding in a TTR Met 119 kindred. 61 54
8102146 1993
22
Thyroxine interactions with transthyretin: a comparison of 10 different naturally occurring human transthyretin variants. 61 54
8345041 1993
23
Free thyroxine assessed with three assays in sera of patients with nonthyroidal illness and of subjects with abnormal concentrations of thyroxine-binding proteins. 61 54
8353953 1993
24
Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. 54 61
8475173 1993
25
X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia. 61 54
8428916 1993
26
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. 54 61
8422721 1993
27
Production and functional analysis of normal and variant recombinant human transthyretin proteins. 61 54
1644839 1992
28
A novel variant of transthyretin (prealbumin), Thr119 to Met, associated with increased thyroxine binding. 61 54
1356051 1992
29
Variations in thyroid hormone transport proteins and their clinical implications. 61 54
1422238 1992
30
Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. 61 54
1849117 1991
31
[Evaluating thyroid gland function in patients with protein anomalies]. 61 54
1907423 1991
32
A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. 54 61
1979335 1990
33
Thyroxine uptake by perfused rat liver. No evidence for facilitation by five different thyroxine-binding proteins. 61 54
2123887 1990
34
Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin. 61 54
2135643 1990
35
Studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. 61 54
2370303 1990
36
Can the type of variant albumin in familial dysalbuminemic hyperthyroxinemia be determined by measuring iodothyronines in serum? 61 54
2253589 1990
37
Differentiating various abnormalities of thyroxin binding to serum proteins by radioelectrophoresis of thyroxin and immunoassay of binding proteins. 54 61
2107039 1990
38
Transient prealbumin-associated hyperthyroxinemia in TSH-producing pituitary adenoma. 61 54
2108434 1990
39
Dyslipidemia, insulin resistance, ectopic lipid accumulation and vascular function in Resistance to Thyroid Hormone β. 61
33524107 2021
40
Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia. 61
32669045 2020
41
Familial Dysalbuminemic Hyperthyroxinemia (FDH), Albumin Gene Variant (R218S), and Risk of Miscarriages in Offspring. 61
32665066 2020
42
Hyperthyroxinemia with a non-suppressed TSH: how to confidently reach a diagnosis in this clinical conundrum. 61
32128699 2020
43
Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity. 61
32635414 2020
44
Familial dysalbuminemic hyperthyroxinemia confounding management of coexistent autoimmune thyroid disease. 61
32101523 2020
45
Free Thyroxine Concentrations in Sera of Individuals with Familial Dysalbuminemic Hyperthyroxinemia: A Comparison of Three Methods of Measurement. 61
31822224 2020
46
The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience. 61
32733382 2020
47
Maternal cognitive function during pregnancy in relation to hypo- and hyperthyroxinemia. 61
31614008 2019
48
Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats. 61
31003143 2019
49
Familial dysalbuminemic hyperthyroxinemia in a 12-year-old girl. 61
31087584 2019
50
Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome. 61
30552134 2019

Variations for Hyperthyroxinemia

Expression for Hyperthyroxinemia

Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for Hyperthyroxinemia

GO Terms for Hyperthyroxinemia

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular receptor signaling pathway GO:0030522 9.43 THRB THRA
2 response to cold GO:0009409 9.4 TRH THRA
3 regulation of heart contraction GO:0008016 9.37 THRB THRA
4 thyroid hormone transport GO:0070327 9.32 TTR SERPINA7
5 type I pneumocyte differentiation GO:0060509 9.26 THRB THRA
6 thyroid hormone mediated signaling pathway GO:0002154 9.16 THRB THRA
7 female courtship behavior GO:0008050 8.96 THRB THRA
8 hormone-mediated signaling pathway GO:0009755 8.92 TSHR TRH THRB THRA

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.96 THRB THRA
2 thyroid hormone binding GO:0070324 8.8 TTR THRB THRA

Sources for Hyperthyroxinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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