MCID: HYP029
MIFTS: 28

Hyperthyroxinemia

Categories: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

MalaCards integrated aliases for Hyperthyroxinemia:

Name: Hyperthyroxinemia 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2855
MeSH 45 D006981
NCIt 51 C131850
UMLS 74 C0020551

Summaries for Hyperthyroxinemia

MalaCards based summary : Hyperthyroxinemia is related to thyroid hormone resistance, generalized, autosomal dominant and multinodular goiter. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include thyroid, pituitary and t cells.

Wikipedia : 77 Hyperthyroxinemia is a thyroid disease where the serum levels of thyroxine are higher than... more...

Related Diseases for Hyperthyroxinemia

Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 thyroid hormone resistance, generalized, autosomal dominant 32.2 SERPINA7 TRH
2 multinodular goiter 29.9 TPO TSHR
3 congenital hypothyroidism 29.7 SERPINA7 TPO TSHR
4 graves' disease 29.5 SERPINA7 TPO TSHR
5 graves disease 1 29.1 SERPINA7 TPO TRH TSHR
6 goiter 28.8 SERPINA7 TPO TRH TSHR
7 thyroiditis 28.8 SERPINA7 TPO TRH TSHR
8 hypothyroidism 28.7 SERPINA7 TPO TRH TSHR TTR
9 hyperthyroxinemia, familial dysalbuminemic 12.7
10 hyperthyroxinemia, dystransthyretinemic 12.7
11 hyperthyroxinemia, euthyroid, caused by generalized 5-prime-deiodinase deficiency 12.1
12 thyroid hormone plasma membrane transport defect 11.2
13 paramyloidosis 10.2 ALB TTR
14 burns 10.2 ALB TTR
15 hepatocellular carcinoma 10.2
16 marasmus 10.2 ALB TTR
17 kwashiorkor 10.2 ALB TTR
18 decubitus ulcer 10.2 ALB TTR
19 aleutian mink disease 10.2 ALB TTR
20 chronic ulcer of skin 10.2 ALB TTR
21 blind loop syndrome 10.2 ALB TTR
22 autonomic nervous system disease 10.2 ALB TTR
23 nervous system disease 10.2 ALB TTR
24 analbuminemia 10.1 ALB TTR
25 euthyroid sick syndrome 10.1 ALB SERPINA7
26 dysentery 10.1 ALB TTR
27 protein-energy malnutrition 10.1 ALB TTR
28 corticosteroid-binding globulin deficiency 10.1 ALB SERPINA7
29 demyelinating polyneuropathy 10.1 ALB TTR
30 thyroid hormone resistance, generalized, autosomal recessive 10.1
31 testicular yolk sac tumor 10.1 ALB TTR
32 obstructive jaundice 10.1 ALB TTR
33 hypothyroidism, congenital, nongoitrous, 2 10.1 SERPINA7 TSHR
34 nutritional deficiency disease 10.1 ALB TTR
35 hashimoto encephalopathy 10.0 TPO TSHR
36 acquired metabolic disease 10.0 ALB TTR
37 myxedema 10.0 TPO TSHR
38 peripheral nervous system disease 10.0 ALB TTR
39 nodular goiter 10.0 TPO TSHR
40 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 TPO TSHR
41 respiratory failure 10.0 ALB TTR
42 amyloidosis, hereditary, transthyretin-related 9.9
43 hypercholesterolemia, familial 9.9
44 pheochromocytoma 9.9
45 myeloma, multiple 9.9
46 hypothyroidism, congenital, nongoitrous, 3 9.9
47 hyperprolactinemia 9.9
48 diabetes mellitus 9.9
49 rickets 9.9
50 primary hyperparathyroidism 9.9

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to Hyperthyroxinemia

Symptoms & Phenotypes for Hyperthyroxinemia

Drugs & Therapeutics for Hyperthyroxinemia

Search Clinical Trials , NIH Clinical Center for Hyperthyroxinemia

Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

Anatomical Context for Hyperthyroxinemia

MalaCards organs/tissues related to Hyperthyroxinemia:

42
Thyroid, Pituitary, T Cells, Testes, Skin

Publications for Hyperthyroxinemia

Articles related to Hyperthyroxinemia:

(show top 50) (show all 135)
# Title Authors Year
1
Familial dysalbuminemic hyperthyroxinemia in a 12-year-old girl. ( 31087584 )
2019
2
Hyperthyroxinemia is positively associated with prevalent and incident type 2 diabetes mellitus in two population-based samples from Northeast Germany and Denmark. ( 29239740 )
2018
3
Hyperthyroxinemia at birth: a cause of idiopathic neonatal hyperbilirubinemia? ( 29721843 )
2018
4
First Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB Variant. ( 27834068 )
2017
5
A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH). ( 27904073 )
2017
6
Familial Dysalbuminemic Hyperthyroxinemia that was Inappropriately Treated with Thiamazole Due to Pseudo-thyrotoxic Symptoms. ( 28781323 )
2017
7
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE. ( 28816534 )
2017
8
Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia. ( 29163366 )
2017
9
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. ( 26777880 )
2016
10
Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P). ( 27081329 )
2016
11
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. ( 25153218 )
2015
12
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. ( 24494774 )
2014
13
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. ( 24646103 )
2014
14
Lithium-induced transient euthyroid hyperthyroxinemia: a case report. ( 25133055 )
2014
15
Anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia and suspected impairment of T4 to T3 conversion: a case report. ( 25237453 )
2014
16
[Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. ( 22781450 )
2012
17
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. ( 21149501 )
2011
18
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. ( 19282355 )
2009
19
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. ( 18724828 )
2008
20
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. ( 17190692 )
2006
21
Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. ( 15833783 )
2005
22
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. ( 15068631 )
2004
23
[The specific features of thyrotoxicosis and euthyroid hyperthyroxinemia developed due to the use of cordarone]. ( 15732718 )
2004
24
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. ( 12743361 )
2003
25
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. ( 12099390 )
2002
26
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. ( 11743520 )
2001
27
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. ( 11385707 )
2001
28
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. ( 10946882 )
2000
29
Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. ( 10352382 )
1999
30
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. ( 10430791 )
1999
31
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. ( 10526251 )
1999
32
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? ( 10999134 )
1999
33
[Hyperthyroxinemia and clinical euthyroidism. Report of one case]. ( 10436700 )
1999
34
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. ( 9329347 )
1997
35
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. ( 8702585 )
1996
36
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( 8784093 )
1996
37
Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. ( 8885441 )
1996
38
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. ( 8929830 )
1996
39
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. ( 8964572 )
1996
40
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. ( 7628382 )
1995
41
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. ( 7829599 )
1995
42
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. ( 7852505 )
1995
43
Familial dysalbuminemic hyperthyroxinemia in pregnancy. ( 8548059 )
1995
44
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. ( 8648063 )
1995
45
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. ( 15251607 )
1995
46
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. ( 7742472 )
1994
47
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. ( 7937417 )
1994
48
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. ( 8048949 )
1994
49
Hyperthyroxinemia after surgery for primary hyperparathyroidism. ( 8052060 )
1994
50
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. ( 8288714 )
1994

Variations for Hyperthyroxinemia

Expression for Hyperthyroxinemia

Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for Hyperthyroxinemia

GO Terms for Hyperthyroxinemia

Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ALB SERPINA7 TPO TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 ALB TPO
2 hormone-mediated signaling pathway GO:0009755 8.96 TRH TSHR
3 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TRH TTR

Sources for Hyperthyroxinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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