MCID: HYP029
MIFTS: 27

Hyperthyroxinemia

Categories: Endocrine diseases

Aliases & Classifications for Hyperthyroxinemia

MalaCards integrated aliases for Hyperthyroxinemia:

Name: Hyperthyroxinemia 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2855
MeSH 44 D006981
UMLS 73 C0020551

Summaries for Hyperthyroxinemia

MalaCards based summary : Hyperthyroxinemia is related to thyroid hormone resistance, generalized, autosomal dominant and neonatal hypothyroidism. An important gene associated with Hyperthyroxinemia is TTR (Transthyretin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include thyroid, pituitary and testes.

Wikipedia : 76 Hyperthyroxinemia or hyperthyroxinaemia is a thyroid disease where the serum levels of thyroxine are... more...

Related Diseases for Hyperthyroxinemia

Diseases related to Hyperthyroxinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 thyroid hormone resistance, generalized, autosomal dominant 31.8 SERPINA7 TRH
2 neonatal hypothyroidism 29.9 TPO TSHR
3 congenital hypothyroidism 29.7 TPO TSHR
4 multinodular goiter 29.5 TPO TSHR
5 graves' disease 28.8 SERPINA7 TPO TSHR
6 thyroiditis 28.3 SERPINA7 TPO TRH TSHR
7 goiter 27.4 SERPINA7 TPO TRH TSHR
8 hyperthyroidism 27.4 SERPINA7 TPO TRH TSHR
9 hypothyroidism 27.1 SERPINA7 TPO TRH TSHR TTR
10 hyperthyroxinemia, familial dysalbuminemic 12.5
11 hyperthyroxinemia, dystransthyretinemic 12.4
12 hyperthyroxinemia, euthyroid, caused by generalized 5-prime-deiodinase deficiency 11.9
13 thyroid hormone plasma membrane transport defect 11.0
14 paramyloidosis 10.4 ALB TTR
15 burns 10.4 ALB TTR
16 kwashiorkor 10.4 ALB TTR
17 chronic ulcer of skin 10.4 ALB TTR
18 marasmus 10.4 ALB TTR
19 decubitus ulcer 10.4 ALB TTR
20 aleutian mink disease 10.4 ALB TTR
21 autonomic nervous system disease 10.4 ALB TTR
22 analbuminemia 10.3 ALB TTR
23 dysentery 10.3 ALB TTR
24 euthyroid sick syndrome 10.3 ALB SERPINA7
25 protein-energy malnutrition 10.3 ALB TTR
26 demyelinating polyneuropathy 10.3 ALB TTR
27 testicular yolk sac tumor 10.3 ALB TTR
28 corticosteroid-binding globulin deficiency 10.3 ALB SERPINA7
29 nutritional deficiency disease 10.3 ALB TTR
30 obstructive jaundice 10.2 ALB TTR
31 hypothyroidism, congenital, nongoitrous, 2 10.2 SERPINA7 TSHR
32 acquired metabolic disease 10.1 ALB TTR
33 respiratory failure 10.1 ALB TTR
34 immune system disease 10.1 ALB TSHR
35 myxedema 10.0 TPO TSHR
36 nervous system disease 10.0 ALB TTR
37 nodular goiter 10.0 TPO TSHR
38 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 TPO TSHR
39 hepatocellular carcinoma 10.0
40 follicular adenoma 9.9 TPO TSHR
41 thyroid hormone resistance, generalized, autosomal recessive 9.9
42 congenital nongoitrous hypothryoidism 1 9.9
43 papillary carcinoma 9.9 TPO TSHR
44 differentiated thyroid carcinoma 9.8 TPO TSHR
45 chromophobe adenoma 9.8 SERPINA7 TRH
46 hypercholesterolemia, familial 9.7
47 pheochromocytoma 9.7
48 myeloma, multiple 9.7
49 aging 9.7
50 hypothyroidism, congenital, nongoitrous, 3 9.7

Graphical network of the top 20 diseases related to Hyperthyroxinemia:



Diseases related to Hyperthyroxinemia

Symptoms & Phenotypes for Hyperthyroxinemia

Drugs & Therapeutics for Hyperthyroxinemia

Search Clinical Trials , NIH Clinical Center for Hyperthyroxinemia

Cochrane evidence based reviews: hyperthyroxinemia

Genetic Tests for Hyperthyroxinemia

Anatomical Context for Hyperthyroxinemia

MalaCards organs/tissues related to Hyperthyroxinemia:

41
Thyroid, Pituitary, Testes

Publications for Hyperthyroxinemia

Articles related to Hyperthyroxinemia:

(show top 50) (show all 134)
# Title Authors Year
1
Hyperthyroxinemia is positively associated with prevalent and incident type 2 diabetes mellitus in two population-based samples from Northeast Germany and Denmark. ( 29239740 )
2018
2
Hyperthyroxinemia at birth: a causeA of idiopathic neonatal hyperbilirubinemia? ( 29721843 )
2018
3
Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia. ( 29163366 )
2017
4
Familial Dysalbuminemic Hyperthyroxinemia that was Inappropriately Treated with Thiamazole Due to Pseudo-thyrotoxic Symptoms. ( 28781323 )
2017
5
First Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB Variant. ( 27834068 )
2017
6
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE. ( 28816534 )
2017
7
Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P). ( 27081329 )
2016
8
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. ( 26777880 )
2016
9
A case of familial dysalbuminemic hyperthyroxinemia (FDH) in Japan: FDH as a possible differential diagnosis of syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH). ( 27904073 )
2016
10
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. ( 24646103 )
2014
11
Anesthetic experience in a clinically euthyroid patient with hyperthyroxinemia and suspected impairment of T4 to T3 conversion: a case report. ( 25237453 )
2014
12
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. ( 24494774 )
2014
13
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. ( 25153218 )
2014
14
Lithium-induced transient euthyroid hyperthyroxinemia: a case report. ( 25133055 )
2014
15
[Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]. ( 22781450 )
2012
16
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. ( 21149501 )
2011
17
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. ( 19282355 )
2009
18
Marked hyperthyroxinemia during amiodarone treatment revealing thyroid hormone resistance syndrome. ( 18724828 )
2008
19
Transient hyperthyroxinemia in newborns from women with autoimmune thyroid disease and raised levels of thyroid peroxidase antibodies. ( 17190692 )
2006
20
Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease. ( 15833783 )
2005
21
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. ( 15068631 )
2004
22
[The specific features of thyrotoxicosis and euthyroid hyperthyroxinemia developed due to the use of cordarone]. ( 15732718 )
2004
23
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. ( 12743361 )
2003
24
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. ( 12099390 )
2002
25
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. ( 11743520 )
2001
26
Transthyretin mutations in hyperthyroxinemia and amyloid diseases. ( 11385707 )
2001
27
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. ( 10946882 )
2000
28
[Hyperthyroxinemia and clinical euthyroidism. Report of one case]. ( 10436700 )
1999
29
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. ( 10430791 )
1999
30
Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. ( 10352382 )
1999
31
A case of familial euthyroid hyperthyroxinemia--thyroid hormone resistance syndrome? ( 10999134 )
1999
32
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. ( 10526251 )
1999
33
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. ( 9329347 )
1997
34
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. ( 8964572 )
1996
35
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. ( 8929830 )
1996
36
A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. ( 8784093 )
1996
37
Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. ( 8885441 )
1996
38
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. ( 8702585 )
1996
39
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. ( 7852505 )
1995
40
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. ( 15251607 )
1995
41
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. ( 7628382 )
1995
42
Familial dysalbuminemic hyperthyroxinemia in pregnancy. ( 8548059 )
1995
43
Hyperthyroxinemia and elevated lipids as paraneoplastic phenomena in hepatocellular carcinoma. A case report. ( 8648063 )
1995
44
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. ( 7829599 )
1995
45
[Thyroxine-binding proteins--familial euthyroid hyperthyroxinemia due to point mutations of transthyretin]. ( 8196175 )
1994
46
Induction of hyperthyroxinemia in BALB/C but not in several other strains of mice. ( 7742472 )
1994
47
Hyperthyroxinemia after surgery for primary hyperparathyroidism. ( 8052060 )
1994
48
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. ( 8288714 )
1994
49
Elevated thyroxine levels in a euthyroid patient. A search for the cause of euthyroid hyperthyroxinemia. ( 7937417 )
1994
50
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. ( 8048949 )
1994

Variations for Hyperthyroxinemia

Expression for Hyperthyroxinemia

Search GEO for disease gene expression data for Hyperthyroxinemia.

Pathways for Hyperthyroxinemia

GO Terms for Hyperthyroxinemia

Cellular components related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 ALB SERPINA7 TPO TTR

Biological processes related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 ALB TPO
2 hormone-mediated signaling pathway GO:0009755 8.96 TRH TSHR
3 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Hyperthyroxinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TRH TTR

Sources for Hyperthyroxinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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