MCID: HYP077
MIFTS: 50

Hypertrichosis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Hypertrichosis

MalaCards integrated aliases for Hypertrichosis:

Name: Hypertrichosis 12 29 6 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:420
MeSH 43 D006983
NCIt 49 C79597
SNOMED-CT 67 29966009 40090008
ICD10 32 L68 L68.3 L68.9
UMLS 71 C0020555

Summaries for Hypertrichosis

Disease Ontology : 12 A hair disease characterized by hair growth that is abnormal in quantity or location.

MalaCards based summary : Hypertrichosis is related to hypertrichosis universalis congenita, ambras type and cantu syndrome. An important gene associated with Hypertrichosis is ARID1B (AT-Rich Interaction Domain 1B), and among its related pathways/superpathways are Chromatin organization and Gastric cancer. The drugs Tacrolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Hypertrichosis is an abnormal amount of hair growth over the body. The two distinct types of... more...

Related Diseases for Hypertrichosis

Diseases in the Hypertrichosis family:

Rare Disorder with Hypertrichosis

Diseases related to Hypertrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 hypertrichosis universalis congenita, ambras type 34.3 TRPS1 HTC2
2 cantu syndrome 33.8 KCNJ8 KCNJ11 ABCC9
3 rare disorder with hypertrichosis 33.7 NAGLU ASXL1 ARID1B
4 coffin-siris syndrome 1 33.5 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
5 cornelia de lange syndrome 32.4 TRPS1 KMT2A ARID1B
6 coffin-siris syndrome 4 32.2 SMARCE1 SMARCA4
7 coffin-siris syndrome 2 32.2 SMARCE1 ARID1A
8 coffin-siris syndrome 3 32.0 SMARCE1 SMARCB1
9 cantú syndrome and related disorders 31.3 KCNJ8 ABCC9
10 spinal meningioma 30.4 SMARCE1 SMARCB1 ARID1B
11 hypertrichosis, congenital generalized, with or without gingival hyperplasia 12.8
12 hypertrichosis lanuginosa congenita 12.7
13 hypertrichosis, anterior cervical 12.6
14 hypertrichosis, congenital anterior cervical, with peripheral sensory and motor neuropathy 12.5
15 x-linked congenital generalized hypertrichosis 12.5
16 hypertrichosis lanuginosa, acquired 12.5
17 facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome 12.4
18 histiocytosis-lymphadenopathy plus syndrome 12.4
19 acromegaloid hypertrichosis syndrome 12.4
20 amaurosis congenita, cone-rod type, with congenital hypertrichosis 12.3
21 facial hypertrichosis 12.3
22 cervical hypertrichosis with underlying kyphoscoliosis 12.3
23 cerebral malformation, seizures, hypertrichosis, and overlapping fingers 12.3
24 barber-say syndrome 12.2
25 fibromatosis, gingival, with hypertrichosis and mental retardation 12.2
26 fontaine progeroid syndrome 12.2
27 wiedemann-steiner syndrome 12.1
28 hypertrichosis of eyelid 12.1
29 autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome 12.1
30 obsolete: eyebrow/eyelashes hypertrichosis 12.1
31 hairy elbows 12.1
32 ramon syndrome 11.8
33 cahmr syndrome 11.6
34 schinzel-giedion midface retraction syndrome 11.5
35 hairy ears, y-linked 11.4
36 schaap taylor baraitser syndrome 11.4
37 trichomegaly 11.4
38 zimmermann-laband syndrome 1 11.4
39 becker nevus syndrome 11.4
40 zimmermann-laband syndrome 11.4
41 congenital smooth muscle hamartoma 11.4
42 acromegaloid facial appearance syndrome 11.4
43 stiff skin syndrome 11.3
44 multicentric osteolysis, nodulosis, and arthropathy 11.3
45 coffin-siris syndrome 8 11.3
46 hairy palms and soles 11.0
47 hyperostosis frontalis interna 11.0
48 variegate porphyria 11.0
49 dysosteosclerosis 11.0
50 fascial dystrophy, congenital 11.0

Symptoms & Phenotypes for Hypertrichosis

GenomeRNAi Phenotypes related to Hypertrichosis according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.72 SMARCB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.72 ARID1A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.72 SMARCB1 SMARCE1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.72 KCNJ11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.72 KCNJ11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.72 KCNJ11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.72 ARID1A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.72 ARID1A KCNJ11 SMARCB1 SMARCE1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.72 SMARCE1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.72 ARID1A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.72 ARID1A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.72 SMARCB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.72 SMARCE1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.72 SMARCE1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.72 ARID1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.72 KCNJ11
17 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.72 KCNJ11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.72 ARID1A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.72 SMARCB1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 SMARCB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.72 SMARCE1
22 Increased Nanog expression GR00371-A-1 9.5 ARID1A SMARCA4 SMARCB1 SMARCE1
23 Increased Nanog expression GR00371-A-2 9.5 SMARCE1
24 Increased Nanog expression GR00371-A-3 9.5 ARID1A
25 Increased Nanog expression GR00371-A-5 9.5 ARID1A

MGI Mouse Phenotypes related to Hypertrichosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.18 ABCC9 ARID1A ARID1B ASXL1 KCNJ11 KMT2A
2 cellular MP:0005384 10.17 ABCC9 ARID1A ASXL1 KMT2A NAGLU SLC29A3
3 cardiovascular system MP:0005385 10.16 ABCC9 ARID1A ARID1B KCNJ11 KCNJ8 KMT2A
4 mortality/aging MP:0010768 10.16 ABCC9 ARID1A ARID1B ASXL1 KCNJ11 KCNJ8
5 immune system MP:0005387 10.06 ARID1A ARID1B ASXL1 KCNJ8 KMT2A NAGLU
6 craniofacial MP:0005382 9.95 ARID1A ASXL1 KMT2A NAGLU SMARCA4 TMEM94
7 muscle MP:0005369 9.81 ABCC9 ARID1A ARID1B KCNJ11 KCNJ8 KMT2A
8 neoplasm MP:0002006 9.43 ARID1A ASXL1 KMT2A SLC29A3 SMARCA4 SMARCB1
9 nervous system MP:0003631 9.36 ARID1A ARID1B KCNJ11 KCNK4 KMT2A NAGLU

Drugs & Therapeutics for Hypertrichosis

Drugs for Hypertrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Anti-Infective Agents Phase 3
4 Dermatologic Agents Phase 3
5 Cyclosporins Phase 3
6 Immunosuppressive Agents Phase 3
7 Antifungal Agents Phase 3
8 Antirheumatic Agents Phase 3
9 Immunologic Factors Phase 3
10 Calcineurin Inhibitors Phase 3
11
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
12
Mycophenolic acid Approved Phase 2 24280-93-1 446541
13 Gastrointestinal Agents Phase 2
14 Antineoplastic Agents, Hormonal Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Antitubercular Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18 Liver Extracts
19 Chlorhexidine gluconate

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Randomized, Controlled, Open-Label Pilot Study of a Novel IPL for Removal of Unwanted Fine Hair Completed NCT01912950 Phase 4
2 Efficacy and Safety of Topical Bimatoprost Solution 0.03% in Stable Vitiligo:A Preliminary Study Withdrawn NCT01202513 Phase 4 Bimatoprost 0.03% topical ophthalmic solution
3 Side-by-Side Comparison of 810 nm Diode Laser Technology With Low Fluence-High Repetition Rate vs Low Fluence-Vacuum Assist - A Split - Extremity Efficacy , Safety and Tolerability Study Completed NCT01212172 Phase 3
4 A Multicenter, Single-arm, Open, Conversion Study From a Cyclosporine (CyA) Based Immunosuppressive Regimen to a Tacrolimus Modified Release, FK506E (MR4), Based Immunosuppressive Regimen in Kidney Transplant Subjects (CONCERTO: Converting Cyclosporine to FK506E (MR4) in Renal Transplantation) Completed NCT00481481 Phase 3 tacrolimus
5 Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction Completed NCT03518398 Phase 3
6 Photodynamic Therapy for Permanent Hair Removal Unknown status NCT00371930 Phase 1, Phase 2
7 A Randomised, Double-blind, Placebo-controlled Trial of FOL-005 to Investigate Clinical Safety and Effect on Hair Growth in Healthy Volunteers Completed NCT02793557 Phase 1, Phase 2 FOL-005
8 Replace Sandostatine® in Three Daily Subcutaneous Injections by a Single Intramuscular Injection of Sandostatine® LP Per Month in Patients With a Diffuse Form of Hyperinsulinism Completed NCT00987168 Phase 2 Sandostatine LP
9 A Randomized Trial for the Treatment of Relapsing Aplastic Anemia With Mycophenolate Mofetil (MMF) and Cyclosporine (CSA) Completed NCT00005935 Phase 2 Mycophenolate mofetil;Cyclosporine
10 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
11 Peterio™ – an Add-on Device for Enhanced Safety of Aesthetic Laser Treatments. Unknown status NCT00441948
12 LASER HAIR REDUCTION BY COMBINED BIPOLAR RF AND 755 nm LASER ENERGIES Unknown status NCT02465788
13 Peterio™ – an Add-on Device for Enhanced Safety of Aesthetic Laser Treatments Unknown status NCT00495443
14 Efficacy and Safety of Platelet Rich Plasma in Androgenetic Alopecia: A Double-Blind, Randomized, Placebo Controlled Trial Unknown status NCT02074943
15 A Descriptive Study on the Effectiveness and Safety of Cyclosporin A Therapy in Steroid Dependent and Steroid Resistant Childhood Nephrotic Syndrome Unknown status NCT03219684
16 Efficacy Evaluation of the Activity of a Cosmetic Product (Topical Use) on Hair Regrowth vs Placebo Completed NCT03273504
17 Effect of Bimatoprost (Lumigan) in Gel Suspension Applied to the Eyelashes on Eyelash Growth Completed NCT00773136 Bimatoprost Suspension
18 A Monocentric, Double-blind, Randomized, Active- and Placebo-controlled Split-scalp Study to Evaluate the Clinical Effectiveness of Platelet-rich Plasma (PRP) in the Treatment of Androgenetic Alopecia Active, not recruiting NCT02591355
19 A Prospective Multi-Center Study of a Novel Dual-Wavelength Laser for Hair Removal Terminated NCT02536092

Search NIH Clinical Center for Hypertrichosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Eflornithine
Eflornithine Hydrochloride

Cochrane evidence based reviews: hypertrichosis

Genetic Tests for Hypertrichosis

Genetic tests related to Hypertrichosis:

# Genetic test Affiliating Genes
1 Hypertrichosis 29

Anatomical Context for Hypertrichosis

MalaCards organs/tissues related to Hypertrichosis:

40
Skin, Ovary, Kidney, Liver, Thyroid, Pituitary, Smooth Muscle

Publications for Hypertrichosis

Articles related to Hypertrichosis:

(show top 50) (show all 1653)
# Title Authors PMID Year
1
You "Cantu": Multidisciplinary Collaboration Resulting in Successful Orthognathic Surgery. 61
31401848 2020
2
Hypertrichotic patches as a mosaic manifestation of Proteus syndrome. 61
32035943 2020
3
Erythrokeratodermia variabilis with hypertrichosis on the lesions. 61
31977560 2020
4
Wiedemann-Steiner syndrome in two patients from Portugal. 61
31710778 2020
5
Changes in Prostaglandin-associated Periorbital Syndrome after Switch from Conventional Prostaglandin F2α Treatment to Omidenepag Isopropyl in 11 Consecutive Patients. 61
31913226 2020
6
A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma. 61
31397400 2020
7
Skin and hair abnormalities of Cantu syndrome: A congenital hypertrichosis due to a genetic alteration mimicking the pharmacological effect of minoxidil. 61
31907964 2020
8
Gingival fibromatosis with congenital hypertrichosis. 61
31983850 2020
9
Rhinologic signs associated with snuff taking. 61
31699623 2020
10
A novel triple combination in treatment of melasma: Significant outcome with far less actives. 61
30920111 2019
11
Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry. 61
31828977 2019
12
PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology. 61
31769892 2019
13
Cantu syndrome and hypopituitarism: implications for endocrine monitoring. 61
31743099 2019
14
Progressive blistering and hypertrichosis in a young child. 61
31778569 2019
15
Systematized naevoid hypertrichosis may herald Happle-Tinschert syndrome. 61
31710127 2019
16
Osteopontin regulatory functions in the hair follicle open a therapeutic approach for hypertrichosis. 61
31774146 2019
17
Faun tail nevus: A series of 15 cases and their management with Intense Pulse Light. 61
31719732 2019
18
Minoxidil-induced hypertrichosis in an 8-month-old infant. 61
31646615 2019
19
Intense pulsed light treatment for Becker's nevus. 61
31416363 2019
20
Gardner fibroma with localized hypertrichosis without adenomatous polyposis coli gene mutation. 61
31403969 2019
21
Michelin Tire Baby Syndrome: A Rare Case with Review of Literature. 61
31696012 2019
22
Effects of Cyclosporine on Palmoplantar Pustulosis and Serum Expression of IL-17, IL-23, and TNF-α. 61
31240637 2019
23
An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes. 61
31487385 2019
24
[Paraneoplastic skin diseases]. 61
31273399 2019
25
Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience. 61
31175705 2019
26
Lasers for Becker's nevus. 61
30762191 2019
27
A novel homozygous frame-shift mutation in the SLC29A3 gene: a new case report and review of literature. 61
31464584 2019
28
Unequaled overgrowth inside and out-an exceptional example of hypertrichosis overlying plexiform neurofibroma. 61
31388536 2019
29
Cholesterol homeostasis: Links to hair follicle biology and hair disorders. 61
31260136 2019
30
Diazoxide for the Treatment of Hypoglycemia Resulting From Dumping Syndrome in a Child. 61
31286099 2019
31
Cutaneous paraneoplastic syndromes. 61
30736994 2019
32
Ramon Syndrome- A Rare Form of Cherubism. 61
31909027 2019
33
Differences in skin lesions of endogenous and exogenous Cushing's patients. 61
31333343 2019
34
Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca2+-Activated K+ Channel SK3 Cause Zimmermann-Laband Syndrome. 61
31155282 2019
35
The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome. 61
30349098 2019
36
A novel 3' untranslated region mutation in the SLC29A3 gene associated with pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus syndrome. 61
30821020 2019
37
Erythematous plaque with hypertrichosis on right lateral thigh of infant. 61
31236940 2019
38
An Interesting Coexistence of Multifocal Hypertrichosis and Hirsutism in Hypomelanosis of Ito. 61
31149581 2019
39
Long-term follow-up of children and young adults with autoimmune hepatitis treated with cyclosporine. 61
30502231 2019
40
Localized Hypertrichosis with Traumatic Panniculitis: A Case Report and Literature Review. 61
31320866 2019
41
ARID1B-Related Disorder 61
31132234 2019
42
H Syndrome - A Case Report. 61
31149577 2019
43
Identification of a novel homozygous frameshift mutation in SLC29A3 gene in a case with H syndrome from Iran. 61
30723056 2019
44
Generalized hypertrichosis due to secukinumab in a patient with moderate psoriasis: A case of serendipity or zemblanity? 61
30963671 2019
45
Hair disorders in cancer survivors. 61
29660423 2019
46
An extraordinary new genus and species of Pseudachorutinae (Collembola: Neanuridae) from Colombia. 61
31717114 2019
47
Hair disorders in patients with cancer. 61
29660422 2019
48
[Skin Changes in POEMS Syndrome]. 61
30988219 2019
49
Porphyria Cutanea Tarda Presenting as Erythema-multiforme Like Lesions. 61
31110391 2019
50
Multidisciplinary eyelid reconstruction in Barber-Say syndrome: A case report. 61
30455119 2019

Variations for Hypertrichosis

ClinVar genetic disease variations for Hypertrichosis:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NAGLU NM_000263.4(NAGLU):c.507_516del (p.Ser169fs)deletion Pathogenic 1564 rs483352897 17:40689535-40689544 17:42537517-42537526
2 ASXL1 NM_015338.5(ASXL1):c.1210C>T (p.Arg404Ter)SNV Pathogenic 30986 rs373145711 20:31021211-31021211 20:32433408-32433408
3 ARID1B NM_020732.3(ARID1B):c.1612C>T (p.Gln538Ter)SNV Pathogenic 374179 rs1057518951 6:157150430-157150430 6:156829296-156829296
4 NAGLU NM_000263.4(NAGLU):c.419A>G (p.Tyr140Cys)SNV Pathogenic/Likely pathogenic 371634 rs753520553 17:40689451-40689451 17:42537433-42537433
5 ARID1B NM_017519.2(ARID1B):c.3406del (p.Leu1136fs)deletion Likely pathogenic 374133 rs1057518918 6:157505463-157505463 6:157184329-157184329
6 KCNJ11 NM_000525.3(KCNJ11):c.185C>G (p.Thr62Arg)SNV Likely pathogenic 373928 rs1057518775 11:17409454-17409454 11:17387907-17387907
7 ARID1B , TMEM242 , ZDHHC14 GRCh37/hg19 6q25.3(chr6:156772218-157870875)x3copy number gain Uncertain significance 523303 6:156772218-157870875

Expression for Hypertrichosis

Search GEO for disease gene expression data for Hypertrichosis.

Pathways for Hypertrichosis

Pathways related to Hypertrichosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A ARID1B
2
Show member pathways
12.4 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
3 12.13 SMARCC2 SMARCB1 SMARCA4 KMT2A ARID1A
4
Show member pathways
11.84 KCNK4 KCNJ8 KCNJ11 ABCC9
5
Show member pathways
11.69 KCNJ8 KCNJ11 ABCC9
6
Show member pathways
11.59 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A
7
Show member pathways
11.53 SMARCC2 SMARCB1 SMARCA4
8 11.33 KCNJ8 KCNJ11 ABCC9
9
Show member pathways
10.95 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A

GO Terms for Hypertrichosis

Cellular components related to Hypertrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.95 TRPS1 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ASXL1
2 protein-containing complex GO:0032991 9.83 TRPS1 SMARCE1 SMARCC2 SMARCB1 SMARCA4
3 npBAF complex GO:0071564 9.55 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A
4 inward rectifying potassium channel GO:0008282 9.5 KCNJ8 KCNJ11 ABCC9
5 brahma complex GO:0035060 9.43 SMARCB1 ARID1B ARID1A
6 SWI/SNF complex GO:0016514 9.43 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
7 SWI/SNF superfamily-type complex GO:0070603 9.37 ARID1B ARID1A
8 nBAF complex GO:0071565 9.1 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A

Biological processes related to Hypertrichosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.87 SMARCE1 SMARCC2 SMARCB1 SMARCA4 NAGLU ARID1B
2 chromatin organization GO:0006325 9.86 SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A ASXL1
3 potassium ion transport GO:0006813 9.73 KCNK4 KCNJ8 KCNJ11 ABCC9
4 potassium ion transmembrane transport GO:0071805 9.71 KCNK4 KCNJ8 KCNJ11 ABCC9
5 potassium ion import across plasma membrane GO:1990573 9.63 KCNJ8 KCNJ11 ABCC9
6 chromatin remodeling GO:0006338 9.63 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
7 response to ATP GO:0033198 9.54 KCNJ11 ABCC9
8 positive regulation by host of viral transcription GO:0043923 9.52 SMARCB1 SMARCA4
9 chromatin-mediated maintenance of transcription GO:0048096 9.51 ARID1B ARID1A
10 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.49 SMARCB1 SMARCA4
11 RNA polymerase I preinitiation complex assembly GO:0001188 9.48 SMARCB1 SMARCA4
12 positive regulation of glucose mediated signaling pathway GO:1902661 9.37 SMARCB1 SMARCA4
13 ATP-dependent chromatin remodeling GO:0043044 9.35 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A
14 nucleosome disassembly GO:0006337 9.02 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A

Molecular functions related to Hypertrichosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 10.02 TRPS1 SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A
2 voltage-gated ion channel activity GO:0005244 9.67 KCNK4 KCNJ8 KCNJ11
3 nuclear receptor binding GO:0016922 9.48 SMARCE1 ARID1A
4 inward rectifier potassium channel activity GO:0005242 9.46 KCNJ8 KCNJ11
5 nucleosomal DNA binding GO:0031492 9.46 SMARCE1 SMARCC2 SMARCB1 SMARCA4
6 lysine-acetylated histone binding GO:0070577 9.43 SMARCA4 KMT2A
7 Tat protein binding GO:0030957 9.4 SMARCB1 SMARCA4
8 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.35 SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A
9 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 9.32 SMARCB1 SMARCA4
10 ATP-activated inward rectifier potassium channel activity GO:0015272 9.26 KCNJ8 KCNJ11
11 transcription coactivator activity GO:0003713 9.17 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ASXL1 ARID1B

Sources for Hypertrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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