Hypertrichosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HYP077 MIFTS: 50	Hypertrichosis Categories: Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Hypertrichosis

MalaCards integrated aliases for Hypertrichosis:

Name: Hypertrichosis ¹² ²⁹ ⁶ ⁴³ ¹⁵ ⁷¹ ³²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Disorders of skin appendages

Hypertrichosis

Hypertrichosis, unspecified

Polytrichia

External Ids:

Disease Ontology ¹² DOID:420

MeSH ⁴³ D006983

NCIt ⁴⁹ C79597

SNOMED-CT ⁶⁷ 29966009 40090008

ICD10 ³² L68 L68.3 L68.9

UMLS ⁷¹ C0020555

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Summaries for Hypertrichosis

Disease Ontology : ¹² A hair disease characterized by hair growth that is abnormal in quantity or location.

MalaCards based summary : Hypertrichosis is related to hypertrichosis universalis congenita, ambras type and cantu syndrome. An important gene associated with Hypertrichosis is ARID1B (AT-Rich Interaction Domain 1B), and among its related pathways/superpathways are Chromatin organization and Gastric cancer. The drugs Tacrolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁴ Hypertrichosis is an abnormal amount of hair growth over the body. The two distinct types of... more...

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Related Diseases for Hypertrichosis

Diseases in the Hypertrichosis family:

Rare Disorder with Hypertrichosis

Diseases related to Hypertrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)

#	Related Disease	Score	Top Affiliating Genes
1	hypertrichosis universalis congenita, ambras type	34.3	TRPS1 HTC2
2	cantu syndrome	33.8	KCNJ8 KCNJ11 ABCC9
3	rare disorder with hypertrichosis	33.7	NAGLU ASXL1 ARID1B
4	coffin-siris syndrome 1	33.5	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
5	cornelia de lange syndrome	32.4	TRPS1 KMT2A ARID1B
6	coffin-siris syndrome 4	32.2	SMARCE1 SMARCA4
7	coffin-siris syndrome 2	32.2	SMARCE1 ARID1A
8	coffin-siris syndrome 3	32.0	SMARCE1 SMARCB1
9	cantú syndrome and related disorders	31.3	KCNJ8 ABCC9
10	spinal meningioma	30.4	SMARCE1 SMARCB1 ARID1B
11	hypertrichosis, congenital generalized, with or without gingival hyperplasia	12.8
12	hypertrichosis lanuginosa congenita	12.7
13	hypertrichosis, anterior cervical	12.6
14	hypertrichosis, congenital anterior cervical, with peripheral sensory and motor neuropathy	12.5
15	x-linked congenital generalized hypertrichosis	12.5
16	hypertrichosis lanuginosa, acquired	12.5
17	facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome	12.4
18	histiocytosis-lymphadenopathy plus syndrome	12.4
19	acromegaloid hypertrichosis syndrome	12.4
20	amaurosis congenita, cone-rod type, with congenital hypertrichosis	12.3
21	facial hypertrichosis	12.3
22	cervical hypertrichosis with underlying kyphoscoliosis	12.3
23	cerebral malformation, seizures, hypertrichosis, and overlapping fingers	12.3
24	barber-say syndrome	12.2
25	fibromatosis, gingival, with hypertrichosis and mental retardation	12.2
26	fontaine progeroid syndrome	12.2
27	wiedemann-steiner syndrome	12.1
28	hypertrichosis of eyelid	12.1
29	autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	12.1
30	obsolete: eyebrow/eyelashes hypertrichosis	12.1
31	hairy elbows	12.1
32	ramon syndrome	11.8
33	cahmr syndrome	11.6
34	schinzel-giedion midface retraction syndrome	11.5
35	hairy ears, y-linked	11.4
36	schaap taylor baraitser syndrome	11.4
37	trichomegaly	11.4
38	zimmermann-laband syndrome 1	11.4
39	becker nevus syndrome	11.4
40	zimmermann-laband syndrome	11.4
41	congenital smooth muscle hamartoma	11.4
42	acromegaloid facial appearance syndrome	11.4
43	stiff skin syndrome	11.3
44	multicentric osteolysis, nodulosis, and arthropathy	11.3
45	coffin-siris syndrome 8	11.3
46	hairy palms and soles	11.0
47	hyperostosis frontalis interna	11.0
48	variegate porphyria	11.0
49	dysosteosclerosis	11.0
50	fascial dystrophy, congenital	11.0

Sources

Symptoms & Phenotypes for Hypertrichosis

GenomeRNAi Phenotypes related to Hypertrichosis according to GeneCards Suite gene sharing:

²⁶ (show all 25)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	9.72	SMARCB1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.72	ARID1A
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.72	SMARCB1 SMARCE1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.72	KCNJ11
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-125	9.72	KCNJ11
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.72	KCNJ11
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.72	ARID1A
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.72	ARID1A KCNJ11 SMARCB1 SMARCE1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.72	SMARCE1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	9.72	ARID1A
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.72	ARID1A
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-194	9.72	SMARCB1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.72	SMARCE1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	9.72	SMARCE1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.72	ARID1A
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-45	9.72	KCNJ11
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-51	9.72	KCNJ11
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.72	ARID1A
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.72	SMARCB1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.72	SMARCB1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	9.72	SMARCE1
22	Increased Nanog expression	GR00371-A-1	9.5	ARID1A SMARCA4 SMARCB1 SMARCE1
23	Increased Nanog expression	GR00371-A-2	9.5	SMARCE1
24	Increased Nanog expression	GR00371-A-3	9.5	ARID1A
25	Increased Nanog expression	GR00371-A-5	9.5	ARID1A

MGI Mouse Phenotypes related to Hypertrichosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.18	ABCC9 ARID1A ARID1B ASXL1 KCNJ11 KMT2A
2	cellular	MP:0005384	10.17	ABCC9 ARID1A ASXL1 KMT2A NAGLU SLC29A3
3	cardiovascular system	MP:0005385	10.16	ABCC9 ARID1A ARID1B KCNJ11 KCNJ8 KMT2A
4	mortality/aging	MP:0010768	10.16	ABCC9 ARID1A ARID1B ASXL1 KCNJ11 KCNJ8
5	immune system	MP:0005387	10.06	ARID1A ARID1B ASXL1 KCNJ8 KMT2A NAGLU
6	craniofacial	MP:0005382	9.95	ARID1A ASXL1 KMT2A NAGLU SMARCA4 TMEM94
7	muscle	MP:0005369	9.81	ABCC9 ARID1A ARID1B KCNJ11 KCNJ8 KMT2A
8	neoplasm	MP:0002006	9.43	ARID1A ASXL1 KMT2A SLC29A3 SMARCA4 SMARCB1
9	nervous system	MP:0003631	9.36	ARID1A ARID1B KCNJ11 KCNK4 KMT2A NAGLU

Sources

Drugs & Therapeutics for Hypertrichosis

Drugs for Hypertrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tacrolimus

Approved, Investigational

Phase 3

104987-11-3

445643 439492 6473866

Synonyms:

(-)-FK 506

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone

104987-11-3

109581-93-3 (Hydrate)

15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,

3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c] [1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN

AC-1182

AC1L1K7H

AC1L97GB

AC1L9IBU

Advagraf

AKOS005145901

Ambap104987-11-3

Ambap5429

Anhydrous tacrolimus

Anhydrous, tacrolimus

BCBcMAP01_000194

Bio-0921

Bio2_000470

Bio2_000950

BRD-K35452788-001-02-1

BSPBio_001279

BSPBio-001279

C01375

C44H69NO10

CCRIS 7124

CHEBI:100924

CHEBI:61049

CHEMBL1200738

CID11158639

CID11556866

CID439492

CID445643

CID5372

CID5472317

CID6426916

CID6436007

CID6473866

CID6536850

CID6610362

CID6912836

CID9832283

CID9853905

CID9918805

CID9940643

CID9963169

Cilag brand OF tacrolimus

CPD000466356

CPD-10016

D08556

DB00864

DivK1c_001040

FK 506

FK5

Fk-506

FK506

FK-506

FR 900506

FR900506

FR-900506

FT-0082660

Fujimycin

Fujisawa brand OF tacrolimus

Graceptor

HMS1362O21

HMS1792O21

HMS1990O21

HMS2051C18

HMS2093M19

HMS503O21

IDI1_001040

IDI1_002225

Janssen brand OF tacrolimus

K506

KBio1_001040

KBio2_000619

KBio2_003187

KBio2_005755

KBio3_001097

KBio3_001098

KBioGR_000619

KBioSS_000619

L 679934

L-679934

LCP-Tacro

LMPK04000003

LS-64247

MLS000759471

MLS001424054

Modigraf

MolPort-003-666-518

NCGC00163470-01

NCGC00163470-02

NCGC00163470-03

NCGC00163470-04

NCGC00179232-01

NChemBio.2007.16-comp1

nchembio.2007.23-comp2

NINDS_001040

NSC717865

Prograf

Prograf (TN)

Prograft

Protopic

Protopy

S5003_Selleck

SAM001246677

SMR000466356

Tacarolimus

tacrolimus

Tacrolimus

Tacrolimus (anhydrous)

Tacrolimus (INN)

Tacrolimus (Prograf?)

Tacrolimus anhydrous

tacrolimus hydrate

Tacrolimus, anhydrous

Tsukubaenolide

UNII-Y5L2157C4J

Miconazole

Approved, Investigational, Vet_approved

Phase 3

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

Aflorix(nitrate)

AKOS001574474

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

Brentan

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

Conofite(nitrate)

CPD-4501

D00416

Dactarin

Daktarin IV

DB01110

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Esteve brand OF miconazole

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

Janssen cilag brand OF miconazole

Janssen-cilag brand OF miconazole

Johnston and johnston brand OF miconazole nitrate

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

Lotrimin AF(nitrate)

LS-78378

MCZ

Micantin (nitrate)

Miconasil nitrate

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

miconazole

Miconazole

Miconazole (JP15/USP/INN)

Miconazole [USAN:BAN:INN:JAN]

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole esteve brand

Miconazole janssen-cilag brand

Miconazole nitrate

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MJR 1762

MLS002222203

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (TN)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

Nitrate, miconasil

Nitrate, miconazole

Novo-Miconazole Vaginal Ovules

NSC 170986

NSC169434

NSC170986

Oprea1_091955

Prestwick_335

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

R 18134

R-14,889

SMR001307249

SPBio_000976

SPBio_002174

Spectrum_000965

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

STK834405

STOCK1S-93556

UNII-7NNO0D7S5M

Vusion

Zimycan

Anti-Infective Agents

Phase 3

Dermatologic Agents

Phase 3

Cyclosporins

Phase 3

Immunosuppressive Agents

Phase 3

Antifungal Agents

Phase 3

Antirheumatic Agents

Phase 3

Immunologic Factors

Phase 3

Calcineurin Inhibitors

Phase 3

Octreotide

Approved, Investigational

Phase 2

83150-76-9

383414 6400441

Synonyms:

(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide

79517-01-4 (acetate salt)

83150-76-9

AC1L1GVU

AC1L8LCD

AC1L9M4X

C07306

C5H12O2.C4H10

CHEBI:427278

CHEBI:611465

CHEMBL1680

CID383414

CID448601

CID54374

Compound 201 995

Compound 201995

Compound 201-995

D00442

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide

D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide

DRG-0115

HMS2090C09

HS-2020

L000453

L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*

Longastatin

LS-177735

LS-187135

NCGC00181796-01

nchembio.184-comp3

NCI60_025753

Octreotida

Octreotida [Spanish]

Octreotide

Octreotide (USAN/INN)

Octreotide [USAN:INN:BAN]

Octreotide acetate

Octreotide acetate salt

Octreotide Acetate Salt

Octreotide-LAR

Octreotidum

Octreotidum [Latin]

Octrotide

SAN 201-995

Sandostatin

Sandostatine

Sandoz 201 995

Sandoz 201995

Sandoz 201-995

SM 201-995

SMS 201-995

SMS-201-995

UNII-RWM8CCW8GP

zacycloicosane-4-carboxamide acetate

Mycophenolic acid

Approved

Phase 2

24280-93-1

446541

Synonyms:

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate

(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid

Acid, mycophenolic

Acide mycophenolique

acido Micofenolico

Acido micofenolico

Acidum mycophenolicum

Melbex

micofenolico acido

Micofenolico acido

Mycophenoic acid

Mycophenolate

Mycophenolic acid

Mycophenolsaeure

Mycophenolsäure

Myfortic

Gastrointestinal Agents

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Antibiotics, Antitubercular

Phase 2

Antitubercular Agents

Phase 2

Anti-Bacterial Agents

Phase 2

Liver Extracts

Chlorhexidine gluconate

Interventional clinical trials:

(show all 19)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized, Controlled, Open-Label Pilot Study of a Novel IPL for Removal of Unwanted Fine Hair	Completed	NCT01912950	Phase 4
2	Efficacy and Safety of Topical Bimatoprost Solution 0.03% in Stable Vitiligo:A Preliminary Study	Withdrawn	NCT01202513	Phase 4	Bimatoprost 0.03% topical ophthalmic solution
3	Side-by-Side Comparison of 810 nm Diode Laser Technology With Low Fluence-High Repetition Rate vs Low Fluence-Vacuum Assist - A Split - Extremity Efficacy , Safety and Tolerability Study	Completed	NCT01212172	Phase 3
4	A Multicenter, Single-arm, Open, Conversion Study From a Cyclosporine (CyA) Based Immunosuppressive Regimen to a Tacrolimus Modified Release, FK506E (MR4), Based Immunosuppressive Regimen in Kidney Transplant Subjects (CONCERTO: Converting Cyclosporine to FK506E (MR4) in Renal Transplantation)	Completed	NCT00481481	Phase 3	tacrolimus
5	Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction	Completed	NCT03518398	Phase 3
6	Photodynamic Therapy for Permanent Hair Removal	Unknown status	NCT00371930	Phase 1, Phase 2
7	A Randomised, Double-blind, Placebo-controlled Trial of FOL-005 to Investigate Clinical Safety and Effect on Hair Growth in Healthy Volunteers	Completed	NCT02793557	Phase 1, Phase 2	FOL-005
8	Replace Sandostatine® in Three Daily Subcutaneous Injections by a Single Intramuscular Injection of Sandostatine® LP Per Month in Patients With a Diffuse Form of Hyperinsulinism	Completed	NCT00987168	Phase 2	Sandostatine LP
9	A Randomized Trial for the Treatment of Relapsing Aplastic Anemia With Mycophenolate Mofetil (MMF) and Cyclosporine (CSA)	Completed	NCT00005935	Phase 2	Mycophenolate mofetil;Cyclosporine
10	Optical Clearing of the Skin in Conjunction With Laser Treatments	Completed	NCT00580736	Phase 1
11	Peterio™ – an Add-on Device for Enhanced Safety of Aesthetic Laser Treatments.	Unknown status	NCT00441948
12	LASER HAIR REDUCTION BY COMBINED BIPOLAR RF AND 755 nm LASER ENERGIES	Unknown status	NCT02465788
13	Peterio™ – an Add-on Device for Enhanced Safety of Aesthetic Laser Treatments	Unknown status	NCT00495443
14	Efficacy and Safety of Platelet Rich Plasma in Androgenetic Alopecia: A Double-Blind, Randomized, Placebo Controlled Trial	Unknown status	NCT02074943
15	A Descriptive Study on the Effectiveness and Safety of Cyclosporin A Therapy in Steroid Dependent and Steroid Resistant Childhood Nephrotic Syndrome	Unknown status	NCT03219684
16	Efficacy Evaluation of the Activity of a Cosmetic Product (Topical Use) on Hair Regrowth vs Placebo	Completed	NCT03273504
17	Effect of Bimatoprost (Lumigan) in Gel Suspension Applied to the Eyelashes on Eyelash Growth	Completed	NCT00773136		Bimatoprost Suspension
18	A Monocentric, Double-blind, Randomized, Active- and Placebo-controlled Split-scalp Study to Evaluate the Clinical Effectiveness of Platelet-rich Plasma (PRP) in the Treatment of Androgenetic Alopecia	Active, not recruiting	NCT02591355
19	A Prospective Multi-Center Study of a Novel Dual-Wavelength Laser for Hair Removal	Terminated	NCT02536092

Search NIH Clinical Center for Hypertrichosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Eflornithine

Eflornithine Hydrochloride

Cochrane evidence based reviews: hypertrichosis

Sources

Genetic Tests for Hypertrichosis

Genetic tests related to Hypertrichosis:

#	Genetic test	Affiliating Genes
1	Hypertrichosis ²⁹

Sources

Anatomical Context for Hypertrichosis

MalaCards organs/tissues related to Hypertrichosis:

⁴⁰

Skin, Ovary, Kidney, Liver, Thyroid, Pituitary, Smooth Muscle

Sources

Publications for Hypertrichosis

Articles related to Hypertrichosis:

(show top 50) (show all 1653)

#	Title	Authors	PMID	Year
1	You "Cantu": Multidisciplinary Collaboration Resulting in Successful Orthognathic Surgery. ⁶¹	Kurian C...Lypka M	31401848	2020
2	Hypertrichotic patches as a mosaic manifestation of Proteus syndrome. ⁶¹	Pithadia DJ...Darling TN	32035943	2020
3	Erythrokeratodermia variabilis with hypertrichosis on the lesions. ⁶¹	Wu JP...Yang C	31977560	2020
4	Wiedemann-Steiner syndrome in two patients from Portugal. ⁶¹	Grangeia A...Moura CP	31710778	2020
5	Changes in Prostaglandin-associated Periorbital Syndrome after Switch from Conventional Prostaglandin F2α Treatment to Omidenepag Isopropyl in 11 Consecutive Patients. ⁶¹	Nakakura S...Kiuchi Y	31913226	2020
6	A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma. ⁶¹	Su X...Ma C	31397400	2020
7	Skin and hair abnormalities of Cantu syndrome: A congenital hypertrichosis due to a genetic alteration mimicking the pharmacological effect of minoxidil. ⁶¹	Ohko K...Sano S	31907964	2020
8	Gingival fibromatosis with congenital hypertrichosis. ⁶¹	Saxena S...Mehrotra S	31983850	2020
9	Rhinologic signs associated with snuff taking. ⁶¹	Hounkpatin SHR...Adjibabi W	31699623	2020
10	A novel triple combination in treatment of melasma: Significant outcome with far less actives. ⁶¹	Pekmezci E	30920111	2019
11	Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry. ⁶¹	Grange DK...van Haaften G	31828977	2019
12	PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology. ⁶¹	Ramot Y...Paus R	31769892	2019
13	Cantu syndrome and hypopituitarism: implications for endocrine monitoring. ⁶¹	Theis NJ...Wheeler BJ	31743099	2019
14	Progressive blistering and hypertrichosis in a young child. ⁶¹	Chen KL...Chiu YE	31778569	2019
15	Systematized naevoid hypertrichosis may herald Happle-Tinschert syndrome. ⁶¹	Hasbun T...Castro A	31710127	2019
16	Osteopontin regulatory functions in the hair follicle open a therapeutic approach for hypertrichosis. ⁶¹	Weiss JM	31774146	2019
17	Faun tail nevus: A series of 15 cases and their management with Intense Pulse Light. ⁶¹	Arora S...Chandra M	31719732	2019
18	Minoxidil-induced hypertrichosis in an 8-month-old infant. ⁶¹	Gomaa AS...Kamaleldeen EB	31646615	2019
19	Intense pulsed light treatment for Becker's nevus. ⁶¹	Wu PR...Ma G	31416363	2019
20	Gardner fibroma with localized hypertrichosis without adenomatous polyposis coli gene mutation. ⁶¹	Yao XY...Zhou C	31403969	2019
21	Michelin Tire Baby Syndrome: A Rare Case with Review of Literature. ⁶¹	Malik F...Tahir F	31696012	2019
22	Effects of Cyclosporine on Palmoplantar Pustulosis and Serum Expression of IL-17, IL-23, and TNF-α. ⁶¹	Jin XH...Xia JX	31240637	2019
23	An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes. ⁶¹	Alam M...Paus R	31487385	2019
24	[Paraneoplastic skin diseases]. ⁶¹	Khoschbin T...Dippel E	31273399	2019
25	Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience. ⁶¹	Ma A...Nichols CG	31175705	2019
26	Lasers for Becker's nevus. ⁶¹	Zhong Y...Man MQ	30762191	2019
27	A novel homozygous frame-shift mutation in the SLC29A3 gene: a new case report and review of literature. ⁶¹	Noavar S...Fahimi H	31464584	2019
28	Unequaled overgrowth inside and out-an exceptional example of hypertrichosis overlying plexiform neurofibroma. ⁶¹	Patterson B...Lakhotia A	31388536	2019
29	Cholesterol homeostasis: Links to hair follicle biology and hair disorders. ⁶¹	Palmer MA...Haslam IS	31260136	2019
30	Diazoxide for the Treatment of Hypoglycemia Resulting From Dumping Syndrome in a Child. ⁶¹	Mejia-Otero JD...Patni N	31286099	2019
31	Cutaneous paraneoplastic syndromes. ⁶¹	Wick MR...Patterson JW	30736994	2019
32	Ramon Syndrome- A Rare Form of Cherubism. ⁶¹	Surej Kumar LK...Dilna S	31909027	2019
33	Differences in skin lesions of endogenous and exogenous Cushing's patients. ⁶¹	Erden F...Kelestemur HF	31333343	2019
34	Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca2+-Activated K+ Channel SK3 Cause Zimmermann-Laband Syndrome. ⁶¹	Bauer CK...Kutsche K	31155282	2019
35	The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome. ⁶¹	van der Sluijs PJ...Santen GWE	30349098	2019
36	A novel 3' untranslated region mutation in the SLC29A3 gene associated with pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus syndrome. ⁶¹	Riachi M...Hussain K	30821020	2019
37	Erythematous plaque with hypertrichosis on right lateral thigh of infant. ⁶¹	Jennings T...Manders SM	31236940	2019
38	An Interesting Coexistence of Multifocal Hypertrichosis and Hirsutism in Hypomelanosis of Ito. ⁶¹	Mendiratta V...Chander R	31149581	2019
39	Long-term follow-up of children and young adults with autoimmune hepatitis treated with cyclosporine. ⁶¹	Nastasio S...Maggiore G	30502231	2019
40	Localized Hypertrichosis with Traumatic Panniculitis: A Case Report and Literature Review. ⁶¹	Ploydaeng M...Suchonwanit P	31320866	2019
41	ARID1B-Related Disorder ⁶¹	Vergano SA...Santen G	31132234	2019
42	H Syndrome - A Case Report. ⁶¹	Yesudian P...Thomas K	31149577	2019
43	Identification of a novel homozygous frameshift mutation in SLC29A3 gene in a case with H syndrome from Iran. ⁶¹	Bagherian R...Heidari A	30723056	2019
44	Generalized hypertrichosis due to secukinumab in a patient with moderate psoriasis: A case of serendipity or zemblanity? ⁶¹	Sacchelli L...Bardazzi F	30963671	2019
45	Hair disorders in cancer survivors. ⁶¹	Freites-Martinez A...Lacouture ME	29660423	2019
46	An extraordinary new genus and species of Pseudachorutinae (Collembola: Neanuridae) from Colombia. ⁶¹	Palacios-Vargas JG	31717114	2019
47	Hair disorders in patients with cancer. ⁶¹	Freites-Martinez A...Lacouture ME	29660422	2019
48	[Skin Changes in POEMS Syndrome]. ⁶¹	Kuwabara S	30988219	2019
49	Porphyria Cutanea Tarda Presenting as Erythema-multiforme Like Lesions. ⁶¹	Parajuli N...Jonkman MF	31110391	2019
50	Multidisciplinary eyelid reconstruction in Barber-Say syndrome: A case report. ⁶¹	Barreiro-Gonzalez A...Evole-Buselli M	30455119	2019

Sources

Genes for Hypertrichosis

Genes related to Hypertrichosis (3 elite genes):

(show all 45)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	430.86	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
2	NAGLU	N-Acetyl-Alpha-Glucosaminidase	Protein Coding	411.82	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
3	ASXL1	ASXL Transcriptional Regulator 1	Protein Coding	411.37	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
4	SLC29A3	Solute Carrier Family 29 Member 3	Protein Coding	33.71	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries (show sections)
5	ABCC9	ATP Binding Cassette Subfamily C Member 9	Protein Coding	23.14	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
6	KCNK4	Potassium Two Pore Domain Channel Subfamily K Member 4	Protein Coding	21.31	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
7	KMT2A	Lysine Methyltransferase 2A	Protein Coding	20.85	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
8	HTC2	Hypertrichosis 2 (Generalized, Congenital)	Genetic Locus	16.42	GeneCards inferred via : Publications Gene name (show sections)
9	LOC106049962	SHH Silencer LOC106049962	Biological Region	15.68	GeneCards inferred via : Publications Summaries (show sections)
10	KCNJ8	Potassium Inwardly Rectifying Channel Subfamily J Member 8	Protein Coding	14.42	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
11	TRPS1	Transcriptional Repressor GATA Binding 1	Protein Coding	13.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	SURF1	SURF1 Cytochrome C Oxidase Assembly Factor	Protein Coding	13.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	13.14	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
14	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	12.86	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
15	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	12.59	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
16	TMEM94	Transmembrane Protein 94	Protein Coding	12.57	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
17	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	12.49	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
18	SMARCC2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 2	Protein Coding	12.32	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
19	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	12.16	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
20	SHBG	Sex Hormone Binding Globulin	Protein Coding	11.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	SLC25A24	Solute Carrier Family 25 Member 24	Protein Coding	11.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	HFE	Homeostatic Iron Regulator	Protein Coding	11.83	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
23	TWIST2	Twist Family BHLH Transcription Factor 2	Protein Coding	11.81	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
24	ARID2	AT-Rich Interaction Domain 2	Protein Coding	11.81	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
25	ABCA5	ATP Binding Cassette Subfamily A Member 5	Protein Coding	11.67	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
26	VPS37A	VPS37A Subunit Of ESCRT-I	Protein Coding	11.62	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
27	FGF5	Fibroblast Growth Factor 5	Protein Coding	11.61	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
28	SOX3	SRY-Box Transcription Factor 3	Protein Coding	11.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
29	SOX9	SRY-Box Transcription Factor 9	Protein Coding	11.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
30	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	10.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
31	FGF13	Fibroblast Growth Factor 13	Protein Coding	10.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
32	PPOX	Protoporphyrinogen Oxidase	Protein Coding	10.88	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
33	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	10.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
34	RNU4ATAC	RNA, U4atac Small Nuclear (U12-Dependent Splicing)	RNA Gene	8.64	DISEASES inferred ¹⁵ ¹⁵
35	HTC1	Hypertrichosis 1 (Universalis, Congenital)	Genetic Locus	7.81	GeneCards inferred via : Gene name (show sections)
36	HTGH	Hypertrichosis Terminalis, Generalized, With Or Without Gingival Hyperplasia	Genetic Locus	7.6	GeneCards inferred via : Gene name (show sections)
37	ITC1	Hypertrichosis Universalis Congenita, Ambras Type	Uncategorized	7.6	GeneCards inferred via : Gene name (show sections)
38	UROS	Uroporphyrinogen III Synthase	Protein Coding	7.55	DISEASES inferred ¹⁵
39	KCNK4-TEX40	KCNK4-TEX40 Readthrough	RNA Gene	7.37	GeneCards inferred via : Variants (show sections)
40	UROD	Uroporphyrinogen Decarboxylase	Protein Coding	7.16	DISEASES inferred ¹⁵
41	DPF2	Double PHD Fingers 2	Protein Coding	7.11	GeneCards inferred via : Disorders (show sections)
42	MMP2	Matrix Metallopeptidase 2	Protein Coding	7.11	GeneCards inferred via : Disorders (show sections)
43	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	6.57	DISEASES inferred ¹⁵
44	BCL6	BCL6 Transcription Repressor	Protein Coding	6.55	GeneCards inferred via : Publications (show sections)
45	BCOR	BCL6 Corepressor	Protein Coding	6.55	GeneCards inferred via : Publications (show sections)

Sources

Variations for Hypertrichosis

ClinVar genetic disease variations for Hypertrichosis:

⁶ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	NAGLU	NM_000263.4(NAGLU):c.507_516del (p.Ser169fs)	deletion	Pathogenic	1564	rs483352897	17:40689535-40689544	17:42537517-42537526
2	ASXL1	NM_015338.5(ASXL1):c.1210C>T (p.Arg404Ter)	SNV	Pathogenic	30986	rs373145711	20:31021211-31021211	20:32433408-32433408
3	ARID1B	NM_020732.3(ARID1B):c.1612C>T (p.Gln538Ter)	SNV	Pathogenic	374179	rs1057518951	6:157150430-157150430	6:156829296-156829296
4	NAGLU	NM_000263.4(NAGLU):c.419A>G (p.Tyr140Cys)	SNV	Pathogenic/Likely pathogenic	371634	rs753520553	17:40689451-40689451	17:42537433-42537433
5	ARID1B	NM_017519.2(ARID1B):c.3406del (p.Leu1136fs)	deletion	Likely pathogenic	374133	rs1057518918	6:157505463-157505463	6:157184329-157184329
6	KCNJ11	NM_000525.3(KCNJ11):c.185C>G (p.Thr62Arg)	SNV	Likely pathogenic	373928	rs1057518775	11:17409454-17409454	11:17387907-17387907
7	ARID1B , TMEM242 , ZDHHC14	GRCh37/hg19 6q25.3(chr6:156772218-157870875)x3	copy number gain	Uncertain significance	523303		6:156772218-157870875

Sources

Expression for Hypertrichosis

Search GEO for disease gene expression data for Hypertrichosis.

Sources

Pathways for Hypertrichosis

Pathways related to Hypertrichosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Chromatin organization ⁶⁵ Show member pathways Chromatin modifying enzymes ⁶⁵ HATs acetylate histones ⁶⁵	12.55	SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A ARID1B
2	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.4	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
3	Chromatin Regulation / Acetylation ⁴	12.13	SMARCC2 SMARCB1 SMARCA4 KMT2A ARID1A
4	Potassium Channels ⁶⁵ Show member pathways HCN channels ⁶⁵ Voltage gated Potassium channels ⁶⁵	11.84	KCNK4 KCNJ8 KCNJ11 ABCC9
5	Inwardly rectifying K+ channels ⁶⁵ Show member pathways Activation of G protein gated Potassium channels ⁶⁵ ATP sensitive Potassium channels ⁶⁵ Defective ABCC8 can cause hypoglycemias and hyperglycemias ⁶⁵ G protein gated Potassium channels ⁶⁵ Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits ⁶⁵ Potassium transport channels ⁶⁵	11.69	KCNJ8 KCNJ11 ABCC9
6	AMPK Enzyme Complex Pathway ⁶³ Show member pathways Chromatin Remodeling ⁶³ mitochondrial L-carnitine shuttle ¹	11.59	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A
7	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	11.53	SMARCC2 SMARCB1 SMARCA4
8	Antiarrhythmic Pathway, Pharmacodynamics ⁶⁰	11.33	KCNJ8 KCNJ11 ABCC9
9	Transcription Ligand-dependent activation of the ESR1/SP pathway ²² Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²²	10.95	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A

Sources

GO Terms for Hypertrichosis

Cellular components related to Hypertrichosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear chromatin	GO:0000790	9.95	TRPS1 SMARCE1 SMARCC2 SMARCB1 SMARCA4 ASXL1
2	protein-containing complex	GO:0032991	9.83	TRPS1 SMARCE1 SMARCC2 SMARCB1 SMARCA4
3	npBAF complex	GO:0071564	9.55	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A
4	inward rectifying potassium channel	GO:0008282	9.5	KCNJ8 KCNJ11 ABCC9
5	brahma complex	GO:0035060	9.43	SMARCB1 ARID1B ARID1A
6	SWI/SNF complex	GO:0016514	9.43	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
7	SWI/SNF superfamily-type complex	GO:0070603	9.37	ARID1B ARID1A
8	nBAF complex	GO:0071565	9.1	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A

Biological processes related to Hypertrichosis according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	9.87	SMARCE1 SMARCC2 SMARCB1 SMARCA4 NAGLU ARID1B
2	chromatin organization	GO:0006325	9.86	SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A ASXL1
3	potassium ion transport	GO:0006813	9.73	KCNK4 KCNJ8 KCNJ11 ABCC9
4	potassium ion transmembrane transport	GO:0071805	9.71	KCNK4 KCNJ8 KCNJ11 ABCC9
5	potassium ion import across plasma membrane	GO:1990573	9.63	KCNJ8 KCNJ11 ABCC9
6	chromatin remodeling	GO:0006338	9.63	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B ARID1A
7	response to ATP	GO:0033198	9.54	KCNJ11 ABCC9
8	positive regulation by host of viral transcription	GO:0043923	9.52	SMARCB1 SMARCA4
9	chromatin-mediated maintenance of transcription	GO:0048096	9.51	ARID1B ARID1A
10	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO:1901838	9.49	SMARCB1 SMARCA4
11	RNA polymerase I preinitiation complex assembly	GO:0001188	9.48	SMARCB1 SMARCA4
12	positive regulation of glucose mediated signaling pathway	GO:1902661	9.37	SMARCB1 SMARCA4
13	ATP-dependent chromatin remodeling	GO:0043044	9.35	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A
14	nucleosome disassembly	GO:0006337	9.02	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1A

Molecular functions related to Hypertrichosis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	10.02	TRPS1 SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A
2	voltage-gated ion channel activity	GO:0005244	9.67	KCNK4 KCNJ8 KCNJ11
3	nuclear receptor binding	GO:0016922	9.48	SMARCE1 ARID1A
4	inward rectifier potassium channel activity	GO:0005242	9.46	KCNJ8 KCNJ11
5	nucleosomal DNA binding	GO:0031492	9.46	SMARCE1 SMARCC2 SMARCB1 SMARCA4
6	lysine-acetylated histone binding	GO:0070577	9.43	SMARCA4 KMT2A
7	Tat protein binding	GO:0030957	9.4	SMARCB1 SMARCA4
8	RNA polymerase II distal enhancer sequence-specific DNA binding	GO:0000980	9.35	SMARCE1 SMARCC2 SMARCB1 SMARCA4 KMT2A
9	RNA polymerase I CORE element sequence-specific DNA binding	GO:0001164	9.32	SMARCB1 SMARCA4
10	ATP-activated inward rectifier potassium channel activity	GO:0015272	9.26	KCNJ8 KCNJ11
11	transcription coactivator activity	GO:0003713	9.17	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ASXL1 ARID1B

Sources

Sources for Hypertrichosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Hypertrichosis

Aliases & Classifications for Hypertrichosis

MalaCards integrated aliases for Hypertrichosis:

Classifications:

External Ids:

Summaries for Hypertrichosis

Related Diseases for Hypertrichosis

Diseases in the Hypertrichosis family:

Diseases related to Hypertrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Hypertrichosis

GenomeRNAi Phenotypes related to Hypertrichosis according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Hypertrichosis:

Drugs & Therapeutics for Hypertrichosis

Drugs for Hypertrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: hypertrichosis

Genetic Tests for Hypertrichosis

Genetic tests related to Hypertrichosis:

Anatomical Context for Hypertrichosis

MalaCards organs/tissues related to Hypertrichosis:

Publications for Hypertrichosis

Articles related to Hypertrichosis:

Genes for Hypertrichosis

Genes related to Hypertrichosis (3 elite genes):

Variations for Hypertrichosis

ClinVar genetic disease variations for Hypertrichosis:

Expression for Hypertrichosis

Pathways for Hypertrichosis

Pathways related to Hypertrichosis according to GeneCards Suite gene sharing:

GO Terms for Hypertrichosis

Cellular components related to Hypertrichosis according to GeneCards Suite gene sharing:

Biological processes related to Hypertrichosis according to GeneCards Suite gene sharing:

Molecular functions related to Hypertrichosis according to GeneCards Suite gene sharing:

Sources for Hypertrichosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :