HOD
MCID: HYP707
MIFTS: 20

Hypertrophic Olivary Degeneration (HOD)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Hypertrophic Olivary Degeneration

MalaCards integrated aliases for Hypertrophic Olivary Degeneration:

Name: Hypertrophic Olivary Degeneration 53
Hod 53

Classifications:



Summaries for Hypertrophic Olivary Degeneration

NIH Rare Diseases : 53 Hypertrophic olivary degeneration (HOD) is a rare neurological condition caused by degeneration in the brain stem, the structure that connects the brain to the spinal cord. Signs and symptoms include palatal tremors, lack of movement coordination (ataxia), Holmes tremor, vision problems, muscle weakness, and gait impairment, along with an MRI showing enlargement (hypertrophy) of the inferior olivary nucleus. The inferior olivary nucleus is the lower part of the olivary body, an oval structure located on each side of the brain stem that assists in cerebellar motor learning and functioning. HOD is considered unique because the olive initially becomes hypertrophic rather than atrophic (wasted). Over time, the olive goes through atrophy. These changes can be followed by MRI, and even though the imaging characteristics of HOD resolve, the clinical hallmarks such as palatal tremor persist. HOD is caused by lesions to the dentate-rubro-olivary pathway (or Guillian-Mollaret triangle). Lesions may be due to bleeding, ischemia (restricted blood flow), vascular malformations, infarct (localized tissue death), tumors, and several neurological diseases, but there are cases of HOD where no cause can be identified. HOD may be classified as unilateral (affecting one side) or bilateral (affecting two sides). The condition is commonly managed with medication, but some cases may require surgery.

MalaCards based summary : Hypertrophic Olivary Degeneration, also known as hod, is related to aceruloplasminemia and tremor. An important gene associated with Hypertrophic Olivary Degeneration is POLG (DNA Polymerase Gamma, Catalytic Subunit). Affiliated tissues include brain, spinal cord and pons.

Related Diseases for Hypertrophic Olivary Degeneration

Diseases related to Hypertrophic Olivary Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 aceruloplasminemia 29.9 POLG SURF1
2 tremor 10.5
3 pontine hemorrhage 10.5
4 lymphoma 10.2
5 cavernous malformation 10.2
6 multiple sclerosis 10.1
7 epidermoid cysts 10.1
8 medulloblastoma 10.1
9 wilson disease 10.1
10 ataxia and polyneuropathy, adult-onset 10.1
11 brain injury 10.1
12 hemangioma 10.1
13 traumatic brain injury 10.1
14 neuroendocrine tumor 10.1
15 central nervous system lymphoma 10.1
16 mutism 10.1
17 cavernous hemangioma 10.1
18 cerebrovascular disease 10.1
19 pathologic nystagmus 10.1
20 ependymoma 10.1
21 primary central nervous system lymphoma 10.1
22 myoclonus 10.1
23 head injury 10.1
24 schizophrenia 10.1
25 sickle cell disease 10.1
26 mitochondrial metabolism disease 9.8 POLG SURF1
27 leigh syndrome 9.8 POLG SURF1
28 charcot-marie-tooth disease 9.7 POLG SURF1

Graphical network of the top 20 diseases related to Hypertrophic Olivary Degeneration:



Diseases related to Hypertrophic Olivary Degeneration

Symptoms & Phenotypes for Hypertrophic Olivary Degeneration

Drugs & Therapeutics for Hypertrophic Olivary Degeneration

Search Clinical Trials , NIH Clinical Center for Hypertrophic Olivary Degeneration

Genetic Tests for Hypertrophic Olivary Degeneration

Anatomical Context for Hypertrophic Olivary Degeneration

MalaCards organs/tissues related to Hypertrophic Olivary Degeneration:

41
Brain, Spinal Cord, Pons, Testes

Publications for Hypertrophic Olivary Degeneration

Articles related to Hypertrophic Olivary Degeneration:

(show top 50) (show all 194)
# Title Authors Year
1
Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review. ( 29382617 )
2018
2
Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition. ( 29279964 )
2018
3
Unilateral Symptomatic Hypertrophic Olivary Degeneration Secondary to Midline Brainstem Cavernous Angioma: A Case Report and Review of the Literature. ( 29061458 )
2018
4
MRI and Tractography in Hypertrophic Olivary Degeneration. ( 29756590 )
2018
5
Hypertrophic Olivary Degeneration Following Listerial Rhombencephalitis. ( 30234466 )
2018
6
Diffusion Tensor Imaging in a Case of Pontine Bleeding Showing Hypertrophic Olivary Degeneration and Cerebellar Ataxia. ( 30483105 )
2018
7
New Radiological Findings of Hypertrophic Olivary Degeneration in Two Patients with Brainstem Lymphoma. ( 30496930 )
2018
8
Fermi resonance controlled product branching in the H + HOD reaction. ( 29911229 )
2018
9
Non-resonant vibrational excitation of HOD and selective bond breaking. ( 29935499 )
2018
10
Mode specific dynamics in bond selective reaction O'(3P) + HOD → O'H + OD/O'D + OH. ( 30089371 )
2018
11
Computing vibration-rotation-tunnelling levels of HOD dimer. ( 30123894 )
2018
12
Phenotype, treatment practice and outcome in the cobalamin-dependent remethylation disorders and MTHFR deficiency: data from the E-HOD registry. ( 30178268 )
2018
13
Pontine Hemorrhage Causing Bilateral Hypertrophic Olivary Degeneration. ( 28694652 )
2017
14
The dentato-rubro-olivary pathway revisited: New MR imaging observations regarding hypertrophic olivary degeneration. ( 28247932 )
2017
15
Hypertrophic olivary degeneration. ( 28754749 )
2017
16
Bilateral surgical damage of the central tegmental tract resulting in bilateral hypertrophic olivary degeneration: An MRI case report. ( 28650218 )
2017
17
Hypertrophic olivary degeneration after cerebellar hemorrhage. ( 28647093 )
2017
18
Idiopathic bilateral hypertrophic olivary degeneration. ( 29275394 )
2017
19
Hypertrophic Olivary Degeneration and Palatal or Oculopalatal Tremor. ( 28706504 )
2017
20
Teaching Neuro<i>Images</i>: Bilateral hypertrophic olivary degeneration following posterior circulation stroke. ( 29084930 )
2017
21
Final Report of the 2016-17 Bylaws and Policy Development Committee: (Reflecting actions taken by the HOD on July 19, 2017). ( 29200462 )
2017
22
Hypertrophic olivary degeneration: Case series and review of literature. ( 27772756 )
2016
23
Hypertrophic olivary degeneration: A clinico-radiologic study. ( 27132500 )
2016
24
Hypertrophic olivary degeneration: unveiling the triangle of Guillain-Mollaret. ( 27191241 )
2016
25
Bilateral Hypertrophic Olivary Degeneration and Holmes Tremor without Palatal Tremor: An Unusual Association. ( 27536461 )
2016
26
Post-operative pediatric cerebellar mutism syndrome and its association with hypertrophic olivary degeneration. ( 27942473 )
2016
27
Hypertrophic Olivary Degeneration: A Neurosurgical Point of View. ( 26588253 )
2016
28
Imaging Features of Hypertrophic Olivary Degeneration. ( 30151471 )
2016
29
Track density imaging of hypertrophic olivary degeneration from multiple sclerosis plaque. ( 30460016 )
2016
30
Effect of Vibrational Pre-Excitation on the Dissociation Dynamics of HOD(2+). ( 27057961 )
2016
31
Rate constant calculations of the GeH4 + OH/OD → GeH3 + H2O/HOD reactions using an ab initio based full-dimensional potential energy surface. ( 27292879 )
2016
32
Mode specificity of the dissociative chemisorption of HOD on rigid Cu(111): an approximate full-dimensional quantum dynamics study. ( 27524633 )
2016
33
Relaxation pathways of the OD stretch fundamental of HOD in liquid H2O. ( 28049324 )
2016
34
AMA HOD approves ACS-sponsored resolution on mass casualty bleeding control. ( 28941441 )
2016
35
Teaching NeuroImages: hypertrophic olivary degeneration in a young man with POLG gene mutation. ( 25713120 )
2015
36
Hypertrophic Olivary Degeneration Secondary to Neuro-BehAset's Disease. ( 25801285 )
2015
37
A case of hypertrophic olivary degeneration after resection of cavernomas of the brain stem and review of the literature. ( 26504394 )
2015
38
Unusual case of posterior fossa syndrome and bilateral hypertrophic olivary degeneration after surgical removal of a large fourth ventricle ependymoma in an adult. ( 25956396 )
2015
39
MRI Findings in Nonlesional Hypertrophic Olivary Degeneration. ( 26073621 )
2015
40
Hypertrophic olivary degeneration secondary to traumatic brain injury: a unique form of trans-synaptic degeneration. ( 26139651 )
2015
41
Hypertrophic olivary degeneration resulting from posterior fossa masses and their treatments. ( 26104225 )
2015
42
Hypertrophic olivary degeneration due to the presence of pontine cavernomas. ( 26588643 )
2015
43
Hypertrophic olivary degeneration secondary to central tegmental tract injury. ( 26185351 )
2015
44
Neuro-BehAset: Pons Involvement with Longitudinal Extension to Midbrain and Hypertrophic Olivary Degeneration. ( 26265903 )
2015
45
Hypertrophic olivary degeneration and cerebrovascular disease: movement in a triangle. ( 25455430 )
2015
46
Magnetic resonance imaging of hypertrophic olivary degeneration. ( 25660593 )
2015
47
Hypertrophic olivary degeneration - a report of two cases. ( 25806143 )
2015
48
Hypertrophic olivary degeneration secondary to pontine haemorrhage. ( 25863998 )
2015
49
Frequency of bilateral hypertrophic olivary degeneration in a large retrospective cohort. ( 24716899 )
2015
50
Simultaneous spectral and temporal analyses of kinetic energies in nonequilibrium systems: theory and application to vibrational relaxation of O-D stretch mode of HOD in water. ( 25494003 )
2015

Variations for Hypertrophic Olivary Degeneration

Expression for Hypertrophic Olivary Degeneration

Search GEO for disease gene expression data for Hypertrophic Olivary Degeneration.

Pathways for Hypertrophic Olivary Degeneration

GO Terms for Hypertrophic Olivary Degeneration

Sources for Hypertrophic Olivary Degeneration

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