MCID: HYP457
MIFTS: 47

Hypertrophic Scars

Categories: Skin diseases

Aliases & Classifications for Hypertrophic Scars

MalaCards integrated aliases for Hypertrophic Scars:

Name: Hypertrophic Scars 41
Scars Hypertrophic 55

Classifications:



External Ids:

ICD10 33 L91.0

Summaries for Hypertrophic Scars

MalaCards based summary : Hypertrophic Scars, also known as scars hypertrophic, is related to scleroderma, familial progressive and diabetic foot ulcers. An important gene associated with Hypertrophic Scars is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. The drugs Silicon and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 76 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

Related Diseases for Hypertrophic Scars

Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 scleroderma, familial progressive 30.5 BMP6 CD36
2 diabetic foot ulcers 30.0 TGFB1 TIMP1
3 keloids 29.3 CD36 SMAD2 SMAD3 TGFB1 TGFB3
4 epidermolysis bullosa dystrophica, pretibial 11.0
5 desmoid tumor 10.9
6 cholecystolithiasis 10.5 BMP6 TGFB1
7 burns 10.5
8 osteochondrosis 10.5 CD36 TGFB1
9 melorheostosis 10.5 BMP6 SMAD2
10 dupuytren contracture 10.4 BMP6 TGFB1
11 spastic paraplegia 3, autosomal dominant 10.4 SMAD2 TGFB1
12 osteofibrous dysplasia 10.3 CD36 TGFB1
13 odontogenic myxoma 10.3 CD36 MMP2
14 ocular cicatricial pemphigoid 10.3 CD36 TGFB1
15 localized scleroderma 10.2 SMAD3 TGFB1
16 scar contracture 10.2
17 type i 10.2
18 gingival disease 10.1 TGFB1 TIMP1
19 diffuse pulmonary fibrosis 10.1 SMAD2 TIMP1
20 endotheliitis 10.0
21 fibromatosis, gingival, 1 10.0 CD36 MMP2 TGFB1
22 conjunctival nevus 10.0 MMP2 TIMP1
23 burn scar 10.0
24 conjunctivochalasis 10.0 MMP2 TIMP1
25 penile disease 10.0 SMAD2 SMAD3 TGFB1
26 hypertensive heart disease 10.0 CD36 MMP2
27 microcystic meningioma 10.0 MMP2 TIMP1
28 ureteral disease 10.0 SMAD2 SMAD3 TGFB1
29 nasal cavity squamous cell carcinoma 10.0 MMP2 TIMP1
30 urinary tract obstruction 10.0 SMAD2 SMAD3 TGFB1
31 sorsby fundus dystrophy 10.0 MMP2 TIMP1
32 lung giant cell carcinoma 9.9 MMP2 TIMP1
33 clear cell adenocarcinoma 9.9 SMAD2 SMAD3
34 gastroschisis 9.9 BMP6 TGFB3
35 gingival overgrowth 9.9 CD36 TGFB1 TIMP1
36 keloid formation 9.8
37 galactorrhea 9.8
38 myelofibrosis 9.8 BMP6 TGFB1 TIMP1
39 microvascular complications of diabetes 3 9.7 BMP6 TGFB1
40 exudative vitreoretinopathy 1 9.7
41 buschke-ollendorff syndrome 9.7
42 basal cell carcinoma 1 9.7
43 breast reconstruction 9.7
44 laryngotracheitis 9.7
45 basal cell carcinoma 9.7
46 folliculitis 9.7
47 impetigo 9.7
48 chickenpox 9.7
49 lichen planus 9.7
50 cleft lip 9.7

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to Hypertrophic Scars

Symptoms & Phenotypes for Hypertrophic Scars

MGI Mouse Phenotypes related to Hypertrophic Scars:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 BMP6 CD36 KRT16 MMP2 SMAD2 SMAD3
2 cardiovascular system MP:0005385 10.05 MMP2 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
3 homeostasis/metabolism MP:0005376 10.01 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4 hematopoietic system MP:0005397 9.98 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
5 craniofacial MP:0005382 9.97 KRT16 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
6 digestive/alimentary MP:0005381 9.95 CD36 KRT16 SMAD2 SMAD3 TGFB1 TGFB3
7 mortality/aging MP:0010768 9.92 CD36 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
8 immune system MP:0005387 9.91 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
9 neoplasm MP:0002006 9.65 MMP2 SMAD2 SMAD3 TGFB1 TIMP1
10 skeleton MP:0005390 9.56 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
11 respiratory system MP:0005388 9.55 MMP2 SMAD2 TGFB1 TGFB3 TIMP1
12 vision/eye MP:0005391 9.1 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Hypertrophic Scars

Drugs for Hypertrophic Scars (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
2
Clobetasol Approved, Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
3
Petrolatum Approved, Investigational Phase 4 8009-03-8
4
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
5
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
10
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
12
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
13 Micronutrients Phase 4,Phase 2
14 Trace Elements Phase 4,Phase 2
15 Dermatologic Agents Phase 4,Phase 2
16 Emollients Phase 4,Phase 3
17 glucocorticoids Phase 4,Phase 3
18 Anti-Infective Agents Phase 4,Phase 3,Phase 1
19 Antioxidants Phase 4,Phase 2,Phase 3
20 Protective Agents Phase 4,Phase 2,Phase 3
21 Vitamins Phase 4,Phase 2
22 Anti-Inflammatory Agents Phase 4
23 Hormone Antagonists Phase 4,Phase 2,Phase 3
24 Hormones Phase 4,Phase 2,Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
26 Anti-Infective Agents, Local Phase 4
27 Central Nervous System Depressants Phase 4
28 Cortisol succinate Phase 4
29 Hydrocortisone 17-butyrate 21-propionate Phase 4
30 Hydrocortisone acetate Phase 4
31 Hydrocortisone-17-butyrate Phase 4
32 Tocopherols Phase 4
33 Tocotrienols Phase 4
34 Antiemetics Phase 4
35 Antineoplastic Agents, Hormonal Phase 4
36 Autonomic Agents Phase 4
37 Gastrointestinal Agents Phase 4
38 Methylprednisolone acetate Phase 4
39 Methylprednisolone Hemisuccinate Phase 4
40 Neuroprotective Agents Phase 4
41 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
42 Prednisolone acetate Phase 4
43 Prednisolone hemisuccinate Phase 4
44 Prednisolone phosphate Phase 4
45 diuretics Phase 4
46 Natriuretic Agents Phase 4
47 Chlorhexidine gluconate Phase 4
48 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
49
Fusidic Acid Approved, Investigational Phase 3 6990-06-3 3000226
50
Dimethyl sulfoxide Approved, Vet_approved Phase 2, Phase 3 67-68-5 679

Interventional clinical trials:

(show top 50) (show all 80)
# Name Status NCT ID Phase Drugs
1 An Investigator-blind Multi-center Prospective Study for the Efficacy and Safety of Silicon Gel (Dermatix) Unknown status NCT01004536 Phase 4
2 Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Completed NCT02487212 Phase 4 0.05% Clobetasol propionate;Petrolatum gel
3 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
4 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
5 1540nm Non Ablative Fractional Laser Treatment of Scars Completed NCT01056211 Phase 4
6 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
7 Prevention and Treatment of Stretch Marks With Stratamark™ Completed NCT03377231 Phase 4
8 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
9 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
10 Silicone Gel to Improve Scar in Microtia Patients Recruiting NCT02518035 Phase 4 Silicone Gel
11 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
12 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Unknown status NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
13 DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction Unknown status NCT02206477 Phase 2, Phase 3 Dimethyl Sulfoxide;Saline 0.9%
14 Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients Completed NCT03376620 Phase 3 1,4-Diaminobutane;10% Urea cream
15 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
16 Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection Completed NCT02886988 Phase 2, Phase 3 Botulinum toxin type A;normal saline
17 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
18 Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma Completed NCT01383187 Phase 2, Phase 3
19 Botulinum Toxin to Improve Results in Epicanthoplasty Recruiting NCT03294382 Phase 3 Botulinum toxin type A;Placebo
20 Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Recruiting NCT03038594 Phase 2, Phase 3 Somatropin;0.09% Saline Solution
21 The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair Enrolling by invitation NCT03219580 Phase 3 5-Fluorouracil;Normal Saline Flush, 0.9% Injectable Solution
22 Intron A for the Treatment of Hypertrophic Scar Withdrawn NCT00686478 Phase 3 interferon alpha 2b
23 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
24 The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Acne Scars Unknown status NCT02126657 Phase 2 70% glycolic acid
25 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults Completed NCT02030275 Phase 2 RXI-109;Placebo
26 Safety and Efficacy Study of PF-06473871 to Reduce Hypertrophic Scars From Recurring Post-Revision Surgery Completed NCT01730339 Phase 2 PF-06473871;PF-06473871
27 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
28 Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001 Completed NCT01494922 Phase 2 EXC 001 (currently called PF-06473871)
29 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
30 A Randomized Study to Evaluate the Safety and Efficacy of Various Doses of STP705 in Subjects With Hypertrophic Scar Recruiting NCT02956317 Phase 1, Phase 2 STP705;Placebo
31 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Revised Hypertrophic Scars Active, not recruiting NCT02246465 Phase 2 RXI-109
32 A Phase 2 Extension Study To Enroll Subjects Who Were Enrolled In B5301001 Study Terminated NCT02205476 Phase 2 PF-06473871;PF-06473871
33 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2 ICX‐RHY‐013
34 Juvista (Avotermin) in Breast Reduction Surgery Scars Terminated NCT00432328 Phase 2 Avotermin
35 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
36 Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis Unknown status NCT01858038 Phase 1
37 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
38 Study to Investigate the Pharmacokinetics, Safety, and Tolerability of BMT101 in Healthy Male Volunteers Completed NCT03133130 Phase 1 BMT101;Placebo
39 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
40 Hypertrophic Scar Prevention by Novel Topical Gel Application Recruiting NCT03403621 Phase 1 Pentamidine Isethionate;Silicone Gels
41 A Study to Evaluate Safety and PK Profiles of OLX10010 in Healthy Subjects Recruiting NCT03569267 Phase 1 OLX10010;Placebo
42 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Active, not recruiting NCT02639117 Phase 1 Vismodegib
43 To Study Gene Expression of Postburn Hypertrophic Scar Unknown status NCT01676168
44 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004 Not Applicable
45 The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial Unknown status NCT02168634 Not Applicable Botulinum Toxins;Placebo
46 Effectivity of Dermatix in Promoting Scar Maturation Unknown status NCT00548210
47 Laser Therapy for Treating Hypertrophic Burn Scars in Children Unknown status NCT01653691 Not Applicable
48 A Substantial Equivalence Study of RD04723 and Predicate Device Unknown status NCT01736969 Not Applicable
49 A Prospective Comparison of Robotic and Endoscopic SMG Resection Via Retroauricular Approach Unknown status NCT01726907 Not Applicable
50 Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study Unknown status NCT01633515 Not Applicable

Search NIH Clinical Center for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

Anatomical Context for Hypertrophic Scars

MalaCards organs/tissues related to Hypertrophic Scars:

41
Skin, Liver, Endothelial

Publications for Hypertrophic Scars

Articles related to Hypertrophic Scars:

(show top 50) (show all 590)
# Title Authors Year
1
Treatment Strategies for Hypopigmentation in the Context of Burn Hypertrophic Scars. ( 29464168 )
2018
2
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
3
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
4
Assessment of Ablative Fractional CO2 Laser and Er:YAG Laser to Treat Hypertrophic Scars in a Red Duroc Pig Model. ( 29718376 )
2018
5
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. ( 29498630 )
2018
6
Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial. ( 29886113 )
2018
7
Reply: Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 29485591 )
2018
8
Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions. ( 29523181 )
2018
9
The effects of platelet-rich plasma on hypertrophic scars fibroblasts. ( 29781178 )
2018
10
I^-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. ( 29476776 )
2018
11
The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29401161 )
2018
12
Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 29485590 )
2018
13
Perspectives for applying the additional study methods for diagnostics optimization of postoperative hypertrophic scars of the head and neck. ( 29783207 )
2018
14
Comparison of the effectiveness of pulsed dye laser vs pulsed dye laser combined with ultrapulse fractional CO<sub>2</sub>laser in the treatment of immature red hypertrophic scars. ( 29392869 )
2018
15
MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. ( 29434768 )
2018
16
Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29309344 )
2018
17
Clinical Outcome of 1064-nm Picosecond Neodymium-Doped Yttrium Aluminium Garnet Laser for the Treatment of Hypertrophic Scars. ( 29757022 )
2018
18
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. ( 29069016 )
2017
19
Intralesional cryotherapy for hypertrophic scars and keloids: a review. ( 29799581 )
2017
20
Laser Modulation of Hypertrophic Scars: Technique and Practice. ( 28888301 )
2017
21
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. ( 28287424 )
2017
22
Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids. ( 29282183 )
2017
23
Clinical efficacy of utilizing Ultrapulse CO<sub>2</sub>combined with fractional CO<sub>2</sub>laser for the treatment of hypertrophic scars in Asians-A prospective clinical evaluation. ( 29058830 )
2017
24
Pleiotropic FTY720 Is a Specific and Potent Therapy for Hypertrophic Scars. ( 28288846 )
2017
25
MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1. ( 28629444 )
2017
26
Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 28654594 )
2017
27
Heterotopic Ossification and Hypertrophic Scars. ( 28888300 )
2017
28
Assessing blood flow, microvasculature, erythema and redness in hypertrophic scars: A cross sectional study showing different features that require precise definitions. ( 28153584 )
2017
29
Hypertrophic Scars: Are Vitamins and Inflammatory Biomarkers Related with the Pathophysiology of Wound Healing? ( 28569361 )
2017
30
Autologous fat grafting in keloids and hypertrophic scars: a review. ( 29799555 )
2017
31
A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study. ( 28009689 )
2017
32
Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. ( 29056521 )
2017
33
Role of Hyaluronidase in the Treatment of Hypertrophic Scars. ( 29140867 )
2017
34
Introduction to Special Issue on Hypertrophic Scars and Keloids. ( 28009688 )
2017
35
Evaluating accuracy and reliability of active stereophotogrammetry using MAVIS III Wound Camera for three-dimensional assessment of hypertrophic scars. ( 28363664 )
2017
36
Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway. ( 28656236 )
2017
37
MicroRNAa89185 regulates transforming growth factora89I^1 and collagena891 in hypertrophic scar fibroblasts. ( 28259900 )
2017
38
Review of Silicone Gel Sheeting and Silicone Gel for the Prevention of Hypertrophic Scars and Keloids. ( 28570253 )
2017
39
Evidence of invasive and non-invasive treatment modalities for hypertrophic scars: A systematic review. ( 28056485 )
2017
40
Biocompatible 5-Aminolevulinic Acid/Au Nanoparticle-Loaded Ethosomal Vesicles for In Vitro Transdermal Synergistic Photodynamic/Photothermal Therapy of Hypertrophic Scars. ( 29247361 )
2017
41
FBP1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis, and collagen expression. ( 28362515 )
2017
42
Current Therapeutic Approach to Hypertrophic Scars. ( 28676850 )
2017
43
Beta adrenergic receptor blockers reduce the occurrence of keloids and hypertrophic scars after cardiac device implantation: a single-institution case-control study. ( 28092339 )
2017
44
Small Molecular TGF-I^1-Inhibitor-Loaded Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars. ( 28875694 )
2017
45
Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar. ( 26644005 )
2016
46
The Incidence of Hypertrophic Scarring and Keloid Formation Following Laser Tattoo Removal with a Quality-switched Nd:YAG Laser. ( 27386045 )
2016
47
Clinical and histological results in the treatment of atrophic and hypertrophic scars using a combined method of radiofrequency, ultrasound, and transepidermal drug delivery. ( 26967960 )
2016
48
IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. ( 26962683 )
2016
49
Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy. ( 27180789 )
2016
50
Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging. ( 26763427 )
2016

Variations for Hypertrophic Scars

Expression for Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for Hypertrophic Scars

Pathways related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 BMP6 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
2
Show member pathways
13.38 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
3
Show member pathways
13.36 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4
Show member pathways
13.15 BMP6 SMAD3 TGFB1 TGFB3 TIMP1
5
Show member pathways
12.93 KRT16 MMP2 SMAD2 SMAD3 TGFB1
6
Show member pathways
12.91 BMP6 TGFB1 TGFB3 TIMP1
7
Show member pathways
12.9 BMP6 TGFB1 TGFB3 TIMP1
8
Show member pathways
12.87 SMAD2 SMAD3 TGFB1 TGFB3
9
Show member pathways
12.74 SMAD2 SMAD3 TGFB1 TGFB3
10 12.71 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
11
Show member pathways
12.65 SMAD2 SMAD3 TGFB1 TGFB3
12
Show member pathways
12.63 MMP2 TGFB1 TGFB3 TIMP1
13
Show member pathways
12.59 BMP6 TGFB1 TGFB3 TIMP1
14
Show member pathways
12.41 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
15
Show member pathways
12.39 SMAD2 SMAD3 TGFB1 TGFB3
16
Show member pathways
12.35 SMAD2 SMAD3 TGFB1 TGFB3
17 12.32 SMAD2 SMAD3 TGFB1 TGFB3
18 12.27 SMAD2 SMAD3 TGFB1 TGFB3
19 12.18 MMP2 SMAD2 TGFB1
20
Show member pathways
12.18 SMAD2 SMAD3 TGFB1
21
Show member pathways
12.16 SMAD2 SMAD3 TGFB1 TGFB3
22
Show member pathways
12.12 SMAD2 SMAD3 TGFB1
23 12.11 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
24 12.08 SMAD2 SMAD3 TGFB1 TGFB3
25
Show member pathways
12.03 MMP2 SMAD3 TGFB1
26 12.02 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
27
Show member pathways
12.01 SMAD2 SMAD3 TGFB1 TGFB3
28 11.98 SMAD2 SMAD3 TGFB1
29 11.95 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
30 11.89 CD36 MMP2 TGFB1 TIMP1
31
Show member pathways
11.81 SMAD2 SMAD3 TGFB1
32
Show member pathways
11.81 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
33 11.78 SMAD2 SMAD3 TGFB1 TGFB3
34 11.73 MMP2 TGFB1 TGFB3 TIMP1
35
Show member pathways
11.72 SMAD2 SMAD3 TGFB1
36 11.68 SMAD2 SMAD3 TGFB1
37
Show member pathways
11.66 SMAD2 SMAD3 TGFB1
38 11.63 MMP2 SMAD2 SMAD3
39 11.6 MMP2 TGFB1 TIMP1
40 11.55 SMAD2 SMAD3 TGFB1
41 11.55 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
42 11.46 CD36 TGFB1 TGFB3
43 11.44 SMAD2 SMAD3 TGFB1 TGFB3
44
Show member pathways
11.41 SMAD2 SMAD3 TGFB1
45 11.38 SMAD2 SMAD3
46 11.28 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
47 11.23 MMP2 TGFB1
48 11.21 CD36 MMP2
49 11.2 SMAD2 SMAD3
50 11.18 BMP6 MMP2 SMAD2 SMAD3 TGFB1 TGFB3

GO Terms for Hypertrophic Scars

Cellular components related to Hypertrophic Scars according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 BMP6 CD36 MMP2 TGFB1 TGFB3 TIMP1
2 platelet alpha granule lumen GO:0031093 9.33 TGFB1 TGFB3 TIMP1
3 SMAD protein complex GO:0071141 9.26 SMAD2 SMAD3
4 extracellular matrix GO:0031012 9.26 MMP2 TGFB1 TGFB3 TIMP1
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 SMAD2 SMAD3 TGFB1 TGFB3
2 positive regulation of gene expression GO:0010628 9.99 CD36 SMAD2 SMAD3 TGFB1
3 cytokine-mediated signaling pathway GO:0019221 9.95 CD36 MMP2 TGFB1 TIMP1
4 negative regulation of gene expression GO:0010629 9.9 CD36 SMAD2 TGFB1
5 in utero embryonic development GO:0001701 9.9 SMAD2 SMAD3 TGFB3
6 aging GO:0007568 9.88 KRT16 TGFB1 TGFB3 TIMP1
7 response to hypoxia GO:0001666 9.88 MMP2 SMAD3 TGFB1 TGFB3
8 BMP signaling pathway GO:0030509 9.85 BMP6 TGFB1 TGFB3
9 cell development GO:0048468 9.81 BMP6 TGFB1 TGFB3
10 platelet degranulation GO:0002576 9.81 CD36 TGFB1 TGFB3 TIMP1
11 regulation of MAPK cascade GO:0043408 9.8 BMP6 TGFB1 TGFB3
12 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.78 BMP6 TGFB1 TGFB3
13 ureteric bud development GO:0001657 9.77 SMAD2 SMAD3 TGFB1
14 positive regulation of protein secretion GO:0050714 9.77 BMP6 TGFB1 TGFB3
15 transforming growth factor beta receptor signaling pathway GO:0007179 9.76 SMAD2 SMAD3 TGFB1 TGFB3
16 positive regulation of cell division GO:0051781 9.75 TGFB1 TGFB3
17 negative regulation of fat cell differentiation GO:0045599 9.74 SMAD3 TGFB1
18 extrinsic apoptotic signaling pathway GO:0097191 9.74 SMAD3 TGFB1
19 response to progesterone GO:0032570 9.74 TGFB1 TGFB3
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 CD36 SMAD3
21 digestive tract development GO:0048565 9.74 TGFB1 TGFB3
22 gastrulation GO:0007369 9.74 SMAD2 SMAD3
23 mesoderm formation GO:0001707 9.74 SMAD2 SMAD3
24 negative regulation of mitotic cell cycle GO:0045930 9.73 SMAD3 TGFB1
25 mammary gland development GO:0030879 9.73 TGFB1 TGFB3
26 embryonic cranial skeleton morphogenesis GO:0048701 9.73 SMAD2 SMAD3
27 positive regulation of protein import into nucleus GO:0042307 9.73 SMAD3 TGFB1
28 developmental growth GO:0048589 9.73 SMAD2 SMAD3
29 embryonic pattern specification GO:0009880 9.72 SMAD2 SMAD3
30 positive regulation of collagen biosynthetic process GO:0032967 9.72 TGFB1 TGFB3
31 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.72 SMAD3 TGFB1
32 cell growth GO:0016049 9.71 TGFB1 TGFB3
33 signal transduction involved in regulation of gene expression GO:0023019 9.71 SMAD2 SMAD3
34 negative regulation of DNA replication GO:0008156 9.71 TGFB1 TGFB3
35 positive regulation of chondrocyte differentiation GO:0032332 9.71 BMP6 SMAD3
36 face morphogenesis GO:0060325 9.71 MMP2 TGFB1 TGFB3
37 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.71 SMAD2 SMAD3 TGFB1 TGFB3
38 cell activation GO:0001775 9.7 TGFB1 TIMP1
39 activin receptor signaling pathway GO:0032924 9.7 SMAD2 SMAD3
40 endoderm development GO:0007492 9.7 SMAD2 SMAD3 TGFB1
41 secondary palate development GO:0062009 9.69 SMAD2 TGFB3
42 lens fiber cell differentiation GO:0070306 9.69 SMAD3 TGFB1
43 response to cholesterol GO:0070723 9.68 SMAD2 TGFB1
44 nodal signaling pathway GO:0038092 9.68 SMAD2 SMAD3
45 salivary gland morphogenesis GO:0007435 9.68 TGFB1 TGFB3
46 primary miRNA processing GO:0031053 9.67 SMAD2 SMAD3
47 pericardium development GO:0060039 9.67 SMAD2 SMAD3
48 cell-cell junction organization GO:0045216 9.67 SMAD3 TGFB1 TGFB3
49 embryonic foregut morphogenesis GO:0048617 9.66 SMAD2 SMAD3
50 response to laminar fluid shear stress GO:0034616 9.66 TGFB1 TGFB3

Molecular functions related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.72 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
2 cytokine activity GO:0005125 9.71 BMP6 TGFB1 TGFB3 TIMP1
3 growth factor activity GO:0008083 9.56 BMP6 TGFB1 TGFB3 TIMP1
4 R-SMAD binding GO:0070412 9.54 SMAD2 SMAD3
5 transforming growth factor beta binding GO:0050431 9.52 CD36 TGFB3
6 enhancer binding GO:0035326 9.51 SMAD2 SMAD3
7 co-SMAD binding GO:0070410 9.49 SMAD2 SMAD3
8 primary miRNA binding GO:0070878 9.48 SMAD2 SMAD3
9 type II transforming growth factor beta receptor binding GO:0005114 9.46 TGFB1 TGFB3
10 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.43 SMAD2 SMAD3
11 type III transforming growth factor beta receptor binding GO:0034714 9.37 TGFB1 TGFB3
12 BMP receptor binding GO:0070700 9.33 BMP6 TGFB1 TGFB3
13 type I transforming growth factor beta receptor binding GO:0034713 9.13 SMAD2 TGFB1 TGFB3
14 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 SMAD2 SMAD3 TGFB1 TGFB3

Sources for Hypertrophic Scars

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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