MCID: HYP457
MIFTS: 42

Hypertrophic Scars

Categories: Skin diseases

Aliases & Classifications for Hypertrophic Scars

MalaCards integrated aliases for Hypertrophic Scars:

Name: Hypertrophic Scars 40
Scars Hypertrophic 54

Classifications:



External Ids:

ICD10 32 L91.0

Summaries for Hypertrophic Scars

MalaCards based summary : Hypertrophic Scars, also known as scars hypertrophic, is related to keloid disorder and telangiectasis. An important gene associated with Hypertrophic Scars is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Silicon and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and endothelial, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 73 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

Related Diseases for Hypertrophic Scars

Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 keloid disorder 31.4 TGFB1 CD36 BMP6
2 telangiectasis 29.9 FBN1 BMP6
3 localized scleroderma 29.7 TGFB1 SMAD3 BMP6
4 epidermolysis bullosa dystrophica, pretibial 11.1
5 myhre syndrome 11.1
6 desmoid tumor 11.1
7 keloid formation 10.3
8 dowling-degos disease 1 10.3
9 acne 10.3
10 folliculitis 10.3
11 skin atrophy 10.2
12 ocular cicatricial pemphigoid 10.2 TGFB1 CD36
13 osteofibrous dysplasia 10.2 TGFB1 CD36
14 cholecystolithiasis 10.2 TGFB1 BMP6
15 eosinophilia-myalgia syndrome 10.2 TGFB1 BMP6
16 skin disease 10.2
17 overgrowth syndrome 10.2
18 tuberculoid leprosy 10.2 TGFB1 BMP6
19 osteochondrosis 10.2 TGFB1 CD36
20 gingival disease 10.2 TIMP1 TGFB1
21 microvascular complications of diabetes 3 10.1 TGFB1 BMP6
22 mid-dermal elastolysis 10.1 TIMP1 FBN1
23 tracheal stenosis 10.1 TGFB1 FBN1
24 breast cyst 10.1 TGFB1 BMP6
25 exanthem 10.1
26 autosomal recessive cutis laxa type i 10.1 TGFB1 FBN1
27 stiff skin syndrome 10.1 TGFB1 FBN1
28 nontuberculous mycobacterial lung disease 10.1 FBN1 BMP6
29 bronchiolitis obliterans 10.0 TIMP1 TGFB1 BMP6
30 herpes zoster 10.0
31 neurofibroma 10.0
32 peyronie's disease 10.0 TGFB1 SMAD3
33 bullous keratopathy 10.0 TGFB1 FBN1
34 autosomal dominant non-syndromic intellectual disability 19 10.0 SMAD3 SMAD2
35 albinism, ocular, with late-onset sensorineural deafness 10.0 SMAD3 SMAD2
36 lentigo maligna melanoma 10.0 TIMP1 MMP2
37 aortic aneurysm, familial thoracic 6 10.0 SMAD3 FBN1
38 heritable thoracic aortic disease 10.0 SMAD3 FBN1
39 hydronephrosis 10.0 TIMP1 TGFB1 FBN1
40 frozen shoulder 9.9 TGFB1 MMP2
41 odontogenic myxoma 9.9 MMP2 CD36
42 conjunctivochalasis 9.9 TIMP1 MMP2
43 myelofibrosis 9.9 TIMP1 TGFB1 BMP6
44 scleroderma, familial progressive 9.9 FBN1 CD36 BMP6
45 lung giant cell carcinoma 9.9 TIMP1 MMP2
46 geleophysic dysplasia 9.9 TGFB1 FBN1
47 loeys-dietz syndrome 1 9.9 SMAD3 FBN1
48 carpal tunnel syndrome 9.9
49 galactorrhea 9.9
50 proteasome-associated autoinflammatory syndrome 1 9.9

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to Hypertrophic Scars

Symptoms & Phenotypes for Hypertrophic Scars

MGI Mouse Phenotypes related to Hypertrophic Scars:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 BMP6 CD36 FBN1 KRT16 MMP2 SMAD2
2 cardiovascular system MP:0005385 10.07 CD36 FBN1 MMP2 SMAD2 SMAD3 TGFB1
3 homeostasis/metabolism MP:0005376 10.01 CD36 FBN1 KRT16 MMP2 SMAD2 SMAD3
4 craniofacial MP:0005382 9.99 FBN1 KRT16 MMP2 SMAD2 SMAD3 TGFB1
5 hematopoietic system MP:0005397 9.98 CD36 FBN1 MMP2 SMAD2 SMAD3 TGFB1
6 endocrine/exocrine gland MP:0005379 9.95 CD36 FBN1 SMAD2 SMAD3 TGFB1 TIMP1
7 mortality/aging MP:0010768 9.92 CD36 FBN1 KRT16 MMP2 SMAD2 SMAD3
8 immune system MP:0005387 9.91 CD36 FBN1 MMP2 SMAD2 SMAD3 TGFB1
9 digestive/alimentary MP:0005381 9.89 CD36 KRT16 SMAD2 SMAD3 TGFB1
10 neoplasm MP:0002006 9.65 MMP2 SMAD2 SMAD3 TGFB1 TIMP1
11 reproductive system MP:0005389 9.63 BMP6 FBN1 SMAD2 SMAD3 TGFB1 TIMP1
12 respiratory system MP:0005388 9.35 FBN1 MMP2 SMAD2 TGFB1 TIMP1
13 skeleton MP:0005390 9.23 BMP6 CD36 FBN1 MMP2 SMAD2 SMAD3

Drugs & Therapeutics for Hypertrophic Scars

Drugs for Hypertrophic Scars (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
2
Clobetasol Approved, Experimental, Investigational Phase 4 25122-41-2, 25122-46-7 32798 5311051
3
Petrolatum Approved, Investigational Phase 4 8009-03-8
4
Tocopherol Approved, Investigational Phase 4 1406-66-2
5
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
7
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
10 Tocotrienol Investigational Phase 4 6829-55-6
11 Protective Agents Phase 4
12 Emollients Phase 4
13 Nutrients Phase 4
14 Micronutrients Phase 4
15 Trace Elements Phase 4
16 Vitamins Phase 4
17 Tocotrienols Phase 4
18 Tocopherols Phase 4
19 Antioxidants Phase 4
20 Hydrocortisone hemisuccinate Phase 4
21 Hydrocortisone 17-butyrate 21-propionate Phase 4
22 glucocorticoids Phase 4
23 Hormone Antagonists Phase 4
24 Hormones Phase 4
25 Triamcinolone diacetate Phase 4
26 triamcinolone acetonide Phase 4
27 Anti-Inflammatory Agents Phase 4
28 Triamcinolone hexacetonide Phase 4
29 Anesthetics Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Sodium Channel Blockers Phase 4
32 Anesthetics, Local Phase 4
33 Diuretics, Potassium Sparing Phase 4
34
Fusidic Acid Approved, Investigational Phase 3 6990-06-3 3000226
35
carbamide peroxide Approved Phase 3 124-43-6
36
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
37 Anti-Bacterial Agents Phase 3
38 Cola Phase 3
39 Gotu Kola Phase 3
40 Dermatologic Agents Phase 2, Phase 3
41 abobotulinumtoxinA Phase 2, Phase 3
42 Botulinum Toxins, Type A Phase 2, Phase 3
43 Neurotransmitter Agents Phase 2, Phase 3
44 Cholinergic Agents Phase 2, Phase 3
45 Botulinum Toxins Phase 2, Phase 3
46 incobotulinumtoxinA Phase 2, Phase 3
47
Ethanol Approved Phase 2 64-17-5 702
48
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
49
Lysine Approved, Nutraceutical Phase 1, Phase 2 56-87-1 5962
50 retinol Phase 2

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 A Randomized Investigator-blind Multi-center Prospective Study for the Efficacy and Safety of Silicon Gel (Dermatix) in the Prevention of Hypertrophic Scar in Subjects Undergoing Caesarean Section Unknown status NCT01004536 Phase 4
2 Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Completed NCT02487212 Phase 4 0.05% Clobetasol propionate;Petrolatum gel
3 Effect of Silicone Gel Versus Contractubex Phonophoresis for Post-burn Hypertrophic Scars: A Single Blind Randomized Controlled Trial Completed NCT03777891 Phase 4
4 A Prospective, Randomized, Investigator-blinded, Placebo-controlled, Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
5 Intralesional Injection of Steroids and/or Botulinum Toxin Type A in Hypertrophic Scars and Keloids for Pain Improvement Recruiting NCT03982862 Phase 4 Triamcinolone;Lidocaine;Botulinum toxin A
6 Topical Treatment With Glucocorticoids to Prevent Hypertrophic Scars and Keloid Due to Central Venous Access in Children Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
7 Efficacy of CICATRIX (Asian Gotu Kola or Pennywort) in the Treatment of Hypertrophic Scars and Keloids Scars. Completed NCT00993005 Phase 3
8 Role of Topical Putrescine (Fibrostat) in 10%Urea (TFU) for Prevention of Hypertrophic Scars in Mammoplasty Patients Completed NCT03376620 Phase 3 1,4-Diaminobutane;10% Urea cream
9 A Randomized, Placebo-Controlled, Double-Blind, Prospective Clinical Trial of Botulinum Toxin Type A in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound Completed NCT02886988 Phase 2, Phase 3 Botulinum toxin type A;normal saline
10 Effect of Cryotherpy on Hypertrophic Scar Active, not recruiting NCT04532840 Phase 2, Phase 3
11 Clinical Evaluation of the Efficacy OF Botulinum Toxin A for Improving Facial Scars (Randomized Clinical Trial ) Active, not recruiting NCT04756882 Phase 2, Phase 3 AbobotulinumtoxinA 500 UNT
12 A Double-blind Placebo Controlled Trial Using Subcutaneous Injections of Intron A for the Treatment of Hypertrophic Scar Withdrawn NCT00686478 Phase 3 interferon alpha 2b
13 Prospective Randomized Study of the Effectiveness of Prospective Randomized Study on the Effectiveness of Pressure Garment Therapy for the Prevention of Hypertrophic Scarring in Burned Children Withdrawn NCT00675974 Phase 2, Phase 3
14 Treatment of Hypertrophic Scars With Intradermal Botox Unknown status NCT03631368 Phase 2 Botox
15 An Open-Label, Multi-Center, Prospective, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery for Hypertrophic Scars in Healthy Adults Unknown status NCT02246465 Phase 2 RXI-109
16 A Randomized, Double-Blind, Within-Subject Placebo Controlled Study to Evaluate the Safety and Efficacy of Various Doses of STP705 Administered as Intradermal Injection in Subjects With Hypertrophic Scar. Unknown status NCT02956317 Phase 1, Phase 2 STP705;Placebo
17 A Multi-Center, Prospective, Randomized, Double-Blind, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery on Transverse Hypertrophic Scars on the Lower Abdomen Resulting From Previous Surgeries in Healthy Adults Completed NCT02030275 Phase 2 RXI-109;Placebo
18 An Independent Evaluator-Blind, Dose-Escalation, Untreated-Controlled, Within-Subject, Phase 2a Therapeutic Exploratory Clinical Trial to Evaluate the Efficacy and Safety of BMT 101 Administration for the Prevention of Hypertrophic Scar Recruiting NCT04012099 Phase 2 BMT101
19 Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars; A Randomized Controlled Double-Blinded Trial Enrolling by invitation NCT03935594 Phase 2 Saline Injection
20 A Long-term Efficacy Assessment Following Initial Scar Revision Surgery And Phase 2 Open-label Study To Evaluate Safety Of Re-treatment With Pf-06473871 Terminated NCT02205476 Phase 2 PF-06473871;PF-06473871
21 Within-subject Randomized Clinical Trial Comparing Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
22 A Randomized, Single Blind, Single Dose, Placebo-controlled, Dose-escalation Phase I Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Intradermal Dosage Form of BMT101 in Healthy Male Volunteers Completed NCT03133130 Phase 1 BMT101;Placebo
23 Double Blind, Single-Center, Randomized, Within Subject Placebo, Phase I Study Evaluating the Effects of Novel Topical Gel in Prevention of Hypertrophic Scar Formation Recruiting NCT03403621 Phase 1 Pentamidine Isethionate;Silicone Gels
24 Comparison of the Blister Fluid Components of Second Degree Burned Patients With the Blister Fluid Components Following Intralesional Cryosurgery of Keloid Scars - A Feasibility Study. Unknown status NCT01627769
25 Intralesional Cryosurgery for the Treatment of Basal Cell Carcinoma of the Lower Extremities in the Elderly - a Feasibility Study Unknown status NCT01633515
26 Dermatix; A Randomized Controlled Trial Measuring Effectivity of Dermatix in Promoting Scar Maturation of Hypertrophic Scars. Unknown status NCT00548210
27 Comparison of the Effectiveness in Prevention of Hypertrophic Scars or Keloids Between Silicone Sheet, Silicone Gel and Paper Steri-strip-A Randomised Controlled Trial. Unknown status NCT00849004
28 Microcyn Scar Management HydroGel, K103163 vs. Kelo-cote® Scar Gel for the Management of Hypertrophic or Keloid Scars Unknown status NCT01736969
29 Effectiveness of a Combined Adequate Pressure and Silicone Intervention in Comparison With Conventional Pressure Therapy for Hypertrophic Scar Treatment: a Randomized Controlled Trial Unknown status NCT03628495
30 Tunable-Dye Laser Therapy to Ameliorate Hypertrophic Scarring in Burned Children Unknown status NCT01653691
31 To Study Gene Expression of Postburn Hypertrophic Scar Unknown status NCT01676168
32 The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial Unknown status NCT02168634 Botulinum Toxins;Placebo
33 Effect of Elastic Bandage With Tension on the Inflammatory Response of Hypertrophic Scars in Patients With Deep Burns: a Randomized Triple Blind Trial Completed NCT04643223
34 Effect of Task Oriented Training and Xbox KinectTM on Hand Function in Pediatric Burn Completed NCT04497103
35 Intralesional Cryotherapy With a Argon Gas Based Device for the Treatment of Keloid and Hypertrophic Scars Completed NCT02063243
36 Intralesional Cryotherapy for Treatment of Keloid Scars: a Prospective Evaluation Completed NCT01994616
37 Assessing and Improving Patient Knowledge About Keloids Completed NCT01176877
38 Pilot Study of Prospective Clinical Trials on Skin Wound Healing in Young and Aged Individuals Completed NCT01040104
39 Randomized, Controlled, Within-patient, Single-blinded Pilot Study to Evaluate the Efficacy of the Ablative Fractional CO2 Laser in the Treatment of Hypertrophic Scars in Adult Burn Patients Completed NCT03240718
40 The Vascularity Changes of Scars With Receiving Pulsed Dye Laser Completed NCT03986346
41 Effects of Pulsed Dye and CO2 Laser in Treatment of Hypertrophic Burn Scars. Completed NCT04769089
42 Effectiveness of Pressure Garment Therapy After Burns Completed NCT01005732
43 The Use of Pressure and Silicone in Children With Skin Grafts After Traumatic Skin Injury: A Randomized Control Trial for Preventative Scar Management Completed NCT01602458
44 Hypertrophic Scarring After Facial Burn: A Pilot, Observational Study of Static and Dynamic Measurements of Facial Scars With the 3-D Scanner Through the Scar Maturation Process Completed NCT00242970
45 The Effectiveness of a Smart Scar Care Pad and Pressure Therapy Versus Pressure Therapy in Hypertrophic Scar Management: a Pilot Study Completed NCT03469830
46 A Multicenter, Randomized, Controlled Clinical Trial of Tissue-engineered Skin Grafts With Autologous Scar Dermal Scaffolds for the Repair of Hypertrophic Scars Recruiting NCT04389164
47 The Safety and Efficacy of Thermo-mechanical System for Fractional Ablation Associated Triamcinolone Acetonide Drug Delivery for the Treatment of Hypertrophic Scars and Keloids Recruiting NCT04597060
48 Multicenter, Double Blind, Randomized, Controlled Clinical Investigation to Evaluate the Performance of Autocross-linked Hyaluronic Acid for the Treatment of Hypertrophic Scars Recruiting NCT04614415
49 "A Prospective, Randomized, Double-blind, Placebo Controlled and Comparative Clinical Study Evaluating Scar-management Modalities for Simple and Effective Management of Hyperproliferative (Hypertrophic) Scars and Keloids" Recruiting NCT04169490
50 Efficacy and Safety of Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars Recruiting NCT04812626 5-Fluorouracil

Search NIH Clinical Center for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

Anatomical Context for Hypertrophic Scars

MalaCards organs/tissues related to Hypertrophic Scars:

40
Skin, Breast, Endothelial, Bone Marrow, Smooth Muscle, Thyroid, Eye

Publications for Hypertrophic Scars

Articles related to Hypertrophic Scars:

(show top 50) (show all 2069)
# Title Authors PMID Year
1
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with different types of scars and keloids. 54 61
19464975 2010
2
Pentoxifylline modifies three-dimensional collagen lattice model contraction and expression of collagen types I and III by human fibroblasts derived from post-burn hypertrophic scars and from normal skin. 61 54
19303218 2009
3
Nonlinear spectral imaging of human hypertrophic scar based on two-photon excited fluorescence and second-harmonic generation. 54 61
19309369 2009
4
Tranilast, an anti-allergic drug, down-regulates the growth of cultured neurofibroma cells derived from neurofibromatosis type 1. 61 54
19282654 2009
5
[Expression of Notch receptors, ligands and downstream target genes in epidermis of hypertrophic scar]. 61 54
19408725 2009
6
Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop. 54 61
18401422 2008
7
Expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts in response to transforming growth factor beta1. 61 54
18616749 2008
8
TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5. 61 54
17671518 2008
9
[Expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars]. 61 54
18457258 2007
10
Basic fibroblast growth factor reduces scar formation in acute incisional wounds. 61 54
17971006 2007
11
Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. 61 54
17688405 2007
12
Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring. 61 54
16498396 2006
13
Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. 54 61
16874413 2006
14
[Effect of asiaticoside on the expression of transforming growth factor-beta mRNA and matrix metalloproteinases in hypertrophic scars]. 61 54
16495179 2006
15
A basic fibroblast growth factor improved the quality of skin grafting in burn patients. 61 54
16199295 2005
16
Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation. 61 54
16217483 2005
17
[A study of the abnormalities of human epiderm in keloids and hypertrophic scars]. 54 61
15363271 2004
18
Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. 54 61
15095275 2004
19
Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids. 61 54
15086768 2004
20
[Distribution and expression of transforming growth factor beta and their receptors in hypertrophic scar]. 61 54
15059449 2004
21
Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels. 54 61
12560674 2003
22
Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. 54 61
14694265 2003
23
[Experimental study of the expression of c-myc, c-fos and proto-oncogenes on hypertrophic and scars]. 54 61
12189705 2002
24
Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. 61 54
11939809 2002
25
Detection of collagens in hypertrophic scars by picrosirius polarization method. 61 54
12390767 2002
26
[Change of gene expression of transforming growth factor-beta1, Smad 2 and Smad 3 in hypertrophic scars skins]. 61 54
11955370 2002
27
[Expression of alpha-smooth muscle actin in scar fibroblasts in vitro]. 54 61
11762220 2001
28
Expression of oncoproteins c-fos and c-jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor. 54 61
11780366 2001
29
Altered expression of keratins during abnormal wound healing in human skin. 54 61
11219730 2001
30
[The significance and characteristics of the gene expressions of c-fos and c-jun in hypertrophic scar and chronic ulcer tissues]. 61 54
11876891 2000
31
[Characteristics of bFGF and TGF-beta expression in dermal chronic ulcers and hypertrophic scars and their effects on tissue repair]. 61 54
12516473 2000
32
Delayed appearance of decorin in healing burn scars. 54 61
10692030 2000
33
[A study on the expressions and the correlation of TGF-beta and alpha-SMA in scars]. 54 61
11593622 2000
34
Exogenous transforming growth factor beta(2) modulates collagen I and collagen III synthesis in proliferative scar xenografts in nude rats. 61 54
10600349 1999
35
Expression of Bcl-2, p53, c-jun and c-fos protooncogenes in keloids and hypertrophic scars. 54 61
10651227 1999
36
Gelatinase activity in keloids and hypertrophic scars. 61 54
10417752 1999
37
Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hypertrophic scars. 54 61
9804346 1998
38
Transforming growth factor-beta in thermally injured patients with hypertrophic scars: effects of interferon alpha-2b. 61 54
9773986 1998
39
Hypertrophic scarring is associated with epidermal abnormalities: an immunohistochemical study. 61 54
9924436 1998
40
Activated keratinocytes in the epidermis of hypertrophic scars. 54 61
9588880 1998
41
Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. 61 54
9466575 1998
42
Primary ex vivo culture of keratinocytes isolated from hypertrophic scars as a means of biochemical characterization of CD36. 61 54
9594363 1998
43
Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings. 61 54
9063511 1996
44
[Comparative study of collagen in hypertrophic and keloid cicatrix]. 61 54
9139458 1996
45
Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars. 61 54
8665780 1996
46
Acceleration of wound healing in diabetic mice by basic fibroblast growth factor. 61 54
8860952 1996
47
Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts. 61 54
8592408 1996
48
Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-beta in human post-burn hypertrophic and mature scars. 61 54
7544762 1995
49
Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts. 54 61
7979045 1994
50
Fibronectin gene expression differs in normal and abnormal human wound healing. 61 54
17168907 1994

Variations for Hypertrophic Scars

Expression for Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for Hypertrophic Scars

Pathways related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 TIMP1 TGFB1 SMAD3 SMAD2 FBN1 BMP6
2
Show member pathways
13.48 TIMP1 TGFB1 SMAD3 SMAD2 MMP2 BMP6
3
Show member pathways
13.29 TGFB1 SMAD3 SMAD2 MMP2 KRT16 CD36
4
Show member pathways
13.2 TGFB1 SMAD3 SMAD2 MMP2 CD36
5
Show member pathways
12.89 TIMP1 TGFB1 FBN1 BMP6
6 12.67 TGFB1 SMAD3 SMAD2 MMP2
7
Show member pathways
12.58 TIMP1 TGFB1 MMP2 FBN1
8
Show member pathways
12.51 TGFB1 SMAD2 MMP2 KRT16
9
Show member pathways
12.32 TGFB1 SMAD3 SMAD2
10 12.22 TGFB1 SMAD3 SMAD2
11 12.2 TGFB1 SMAD3 SMAD2
12
Show member pathways
12.17 TGFB1 SMAD3 MMP2
13 12.16 TGFB1 SMAD2 MMP2
14
Show member pathways
12.14 TGFB1 SMAD3 SMAD2
15
Show member pathways
12.08 TGFB1 SMAD3 SMAD2
16 12.06 TGFB1 SMAD3 SMAD2 BMP6
17 12.01 TGFB1 SMAD3 SMAD2
18 12 TGFB1 SMAD3 SMAD2 MMP2
19 11.95 TGFB1 SMAD3 SMAD2 BMP6
20 11.93 TGFB1 SMAD3 SMAD2
21 11.77 TGFB1 SMAD3 SMAD2
22
Show member pathways
11.74 TGFB1 SMAD3 SMAD2
23
Show member pathways
11.73 TGFB1 SMAD3 SMAD2
24 11.71 TIMP1 TGFB1 MMP2
25 11.68 TIMP1 TGFB1 MMP2 CD36
26
Show member pathways
11.64 TGFB1 SMAD3 SMAD2
27 11.6 TGFB1 SMAD3 SMAD2
28
Show member pathways
11.58 TGFB1 SMAD3 SMAD2
29 11.54 SMAD3 SMAD2 MMP2
30 11.51 TIMP1 TGFB1 MMP2
31 11.46 TGFB1 SMAD3 SMAD2
32 11.46 TGFB1 SMAD3 SMAD2 MMP2
33 11.39 TGFB1 SMAD3 SMAD2
34 11.36 SMAD3 SMAD2
35
Show member pathways
11.36 TGFB1 SMAD3 SMAD2 MMP2
36 11.21 TGFB1 MMP2
37 11.19 MMP2 CD36
38 11.17 SMAD3 SMAD2
39 11.09 TGFB1 SMAD3 SMAD2
40 11.09 TGFB1 SMAD3 SMAD2 MMP2 BMP6
41 11.07 TGFB1 SMAD2
42 10.99 TGFB1 SMAD3 SMAD2 FBN1 BMP6
43 10.98 SMAD3 SMAD2 FBN1
44 10.92 SMAD3 SMAD2
45 10.85 TIMP1 TGFB1 FBN1 BMP6
46 10.69 TGFB1 SMAD3 SMAD2

GO Terms for Hypertrophic Scars

Cellular components related to Hypertrophic Scars according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TIMP1 TGFB1 MMP2 FBN1 CD36 BMP6
2 heteromeric SMAD protein complex GO:0071144 9.16 SMAD3 SMAD2
3 SMAD protein complex GO:0071141 8.96 SMAD3 SMAD2
4 extracellular matrix GO:0031012 8.92 TIMP1 TGFB1 MMP2 FBN1

Biological processes related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.02 TGFB1 SMAD3 SMAD2 CD36 BMP6
2 heart development GO:0007507 9.89 TGFB1 SMAD2 FBN1
3 positive regulation of gene expression GO:0010628 9.89 TGFB1 SMAD3 SMAD2 CD36 BMP6
4 cellular protein metabolic process GO:0044267 9.88 TIMP1 MMP2 FBN1
5 cytokine-mediated signaling pathway GO:0019221 9.88 TIMP1 TGFB1 MMP2 CD36
6 aging GO:0007568 9.86 TIMP1 TGFB1 KRT16
7 response to hypoxia GO:0001666 9.86 TGFB1 SMAD3 MMP2
8 skeletal system development GO:0001501 9.85 SMAD3 FBN1 BMP6
9 anatomical structure morphogenesis GO:0009653 9.84 SMAD3 SMAD2 FBN1
10 platelet degranulation GO:0002576 9.83 TIMP1 TGFB1 CD36
11 transforming growth factor beta receptor signaling pathway GO:0007179 9.8 TGFB1 SMAD3 SMAD2
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 TGFB1 CD36 BMP6
13 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.76 TGFB1 SMAD3 SMAD2
14 positive regulation of protein secretion GO:0050714 9.72 TGFB1 BMP6
15 T cell activation GO:0042110 9.72 TGFB1 SMAD3
16 extrinsic apoptotic signaling pathway GO:0097191 9.72 TGFB1 SMAD3
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 SMAD3 CD36
18 positive regulation of protein import into nucleus GO:0042307 9.72 TGFB1 SMAD3
19 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.71 TGFB1 SMAD3
20 negative regulation of mitotic cell cycle GO:0045930 9.71 TGFB1 SMAD3
21 gastrulation GO:0007369 9.71 SMAD3 SMAD2
22 embryonic cranial skeleton morphogenesis GO:0048701 9.71 SMAD3 SMAD2
23 mesoderm formation GO:0001707 9.7 SMAD3 SMAD2
24 face morphogenesis GO:0060325 9.7 TGFB1 MMP2
25 embryonic pattern specification GO:0009880 9.7 SMAD3 SMAD2
26 cellular response to transforming growth factor beta stimulus GO:0071560 9.7 TGFB1 SMAD3 FBN1
27 developmental growth GO:0048589 9.69 SMAD3 SMAD2
28 cell-cell junction organization GO:0045216 9.69 TGFB1 SMAD3
29 positive regulation of epithelial to mesenchymal transition GO:0010718 9.69 TGFB1 SMAD3 SMAD2
30 activin receptor signaling pathway GO:0032924 9.68 SMAD3 SMAD2
31 adrenal gland development GO:0030325 9.68 SMAD3 SMAD2
32 signal transduction involved in regulation of gene expression GO:0023019 9.68 SMAD3 SMAD2
33 positive regulation of chondrocyte differentiation GO:0032332 9.67 SMAD3 BMP6
34 positive regulation of SMAD protein signal transduction GO:0060391 9.67 TGFB1 BMP6
35 response to cholesterol GO:0070723 9.65 TGFB1 SMAD2
36 lens fiber cell differentiation GO:0070306 9.65 TGFB1 SMAD3
37 cell activation GO:0001775 9.65 TIMP1 TGFB1
38 ureteric bud development GO:0001657 9.65 TGFB1 SMAD3 SMAD2
39 cellular response to UV-A GO:0071492 9.64 TIMP1 MMP2
40 positive regulation of vascular permeability GO:0043117 9.64 TGFB1 BMP6
41 primary miRNA processing GO:0031053 9.63 SMAD3 SMAD2
42 positive regulation of bone mineralization GO:0030501 9.63 TGFB1 SMAD3 BMP6
43 nodal signaling pathway GO:0038092 9.62 SMAD3 SMAD2
44 wound healing GO:0042060 9.62 TIMP1 TGFB1 SMAD3 SMAD2
45 cellular response to insulin-like growth factor stimulus GO:1990314 9.61 TGFB1 FBN1
46 pericardium development GO:0060039 9.61 SMAD3 SMAD2
47 embryonic foregut morphogenesis GO:0048617 9.59 SMAD3 SMAD2
48 endoderm development GO:0007492 9.58 TGFB1 SMAD3 SMAD2
49 regulation of striated muscle tissue development GO:0016202 9.57 TGFB1 SMAD3
50 common-partner SMAD protein phosphorylation GO:0007182 9.56 TGFB1 SMAD2

Molecular functions related to Hypertrophic Scars according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.58 TIMP1 TGFB1 BMP6
2 growth factor activity GO:0008083 9.5 TIMP1 TGFB1 BMP6
3 R-SMAD binding GO:0070412 9.37 SMAD3 SMAD2
4 I-SMAD binding GO:0070411 9.26 SMAD3 SMAD2
5 co-SMAD binding GO:0070410 9.16 SMAD3 SMAD2
6 type I transforming growth factor beta receptor binding GO:0034713 8.96 TGFB1 SMAD2
7 transforming growth factor beta receptor binding GO:0005160 8.8 TGFB1 SMAD3 SMAD2

Sources for Hypertrophic Scars

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....