MCID: HYP457
MIFTS: 47

Hypertrophic Scars

Categories: Skin diseases

Aliases & Classifications for Hypertrophic Scars

MalaCards integrated aliases for Hypertrophic Scars:

Name: Hypertrophic Scars 41
Scars Hypertrophic 55

Classifications:



External Ids:

ICD10 33 L91.0

Summaries for Hypertrophic Scars

MalaCards based summary : Hypertrophic Scars, also known as scars hypertrophic, is related to keloids and scleroderma, familial progressive. An important gene associated with Hypertrophic Scars is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. The drugs Silicon and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 76 A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen... more...

Related Diseases for Hypertrophic Scars

Diseases related to Hypertrophic Scars via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 keloids 30.8 CD36 SMAD2 SMAD3 TGFB1 TGFB3
2 scleroderma, familial progressive 30.2 BMP6 CD36
3 epidermolysis bullosa dystrophica, pretibial 11.2
4 desmoid tumor 11.0
5 burns 10.3
6 scar contracture 10.2
7 cholecystolithiasis 10.2 BMP6 TGFB1
8 autosomal recessive cutis laxa type i 10.2 SMAD2 TGFB1
9 eosinophilia-myalgia syndrome 10.2 BMP6 TGFB1
10 penile disease 10.2 SMAD2 TGFB1
11 osteochondrosis 10.2 CD36 TGFB1
12 melorheostosis 10.1 BMP6 SMAD2
13 dupuytren contracture 10.1 BMP6 TGFB1
14 newcastle disease 10.1 CD36 TGFB1
15 spastic paraplegia 3, autosomal dominant 10.1 SMAD2 TGFB1
16 osteofibrous dysplasia 10.1 CD36 TGFB1
17 ocular cicatricial pemphigoid 10.1 CD36 TGFB1
18 burn scar 10.1
19 odontogenic myxoma 10.1 CD36 MMP2
20 localized scleroderma 10.1 SMAD3 TGFB1
21 gingival disease 10.0 TGFB1 TIMP1
22 diffuse pulmonary fibrosis 10.0 SMAD2 TIMP1
23 peyronie disease 10.0 TGFB1 TGFB3
24 microcystic meningioma 10.0 MMP2 TIMP1
25 fibromatosis, gingival, 1 10.0 CD36 MMP2 TGFB1
26 conjunctival nevus 10.0 MMP2 TIMP1
27 conjunctivochalasis 10.0 MMP2 TIMP1
28 spondylocarpotarsal synostosis syndrome 10.0 SMAD2 SMAD3
29 nasal cavity squamous cell carcinoma 10.0 MMP2 TIMP1
30 ureteral disease 10.0 SMAD2 SMAD3 TGFB1
31 urinary tract obstruction 10.0 SMAD2 SMAD3 TGFB1
32 hypertensive heart disease 10.0 CD36 MMP2
33 obstructive nephropathy 10.0 SMAD2 SMAD3 TGFB1
34 maxillary cancer 10.0 MMP2 TIMP1
35 lung giant cell carcinoma 10.0 MMP2 TIMP1
36 sorsby fundus dystrophy 10.0 MMP2 TIMP1
37 clear cell adenocarcinoma 10.0 SMAD2 SMAD3
38 keloid formation 10.0
39 galactorrhea 10.0
40 spinal muscular atrophy 10.0
41 proximal spinal muscular atrophy 10.0
42 loeys-dietz syndrome 4 9.9 SMAD3 TGFB3
43 myelofibrosis 9.9 BMP6 TGFB1 TIMP1
44 juvenile nasopharyngeal angiofibroma 9.9 BMP6 TGFB3
45 pulmonary fibrosis 9.9 SMAD3 TGFB1 TIMP1
46 vitreoretinopathy, neovascular inflammatory 9.9 TGFB1 TIMP1
47 oral submucous fibrosis 9.9 MMP2 TGFB1 TIMP1
48 tuberculoid leprosy 9.9 BMP6 TGFB1 TGFB3
49 peyronie's disease 9.8 SMAD3 TGFB1 TGFB3
50 hypochondrogenesis 9.8 SMAD2 SMAD3 TGFB3

Graphical network of the top 20 diseases related to Hypertrophic Scars:



Diseases related to Hypertrophic Scars

Symptoms & Phenotypes for Hypertrophic Scars

MGI Mouse Phenotypes related to Hypertrophic Scars:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 BMP6 CD36 KRT16 MMP2 SMAD2 SMAD3
2 cardiovascular system MP:0005385 10.05 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
3 homeostasis/metabolism MP:0005376 10.01 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4 hematopoietic system MP:0005397 9.98 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
5 craniofacial MP:0005382 9.97 KRT16 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
6 digestive/alimentary MP:0005381 9.95 CD36 KRT16 SMAD2 SMAD3 TGFB1 TGFB3
7 mortality/aging MP:0010768 9.92 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
8 immune system MP:0005387 9.91 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
9 neoplasm MP:0002006 9.65 MMP2 SMAD2 SMAD3 TGFB1 TIMP1
10 skeleton MP:0005390 9.56 BMP6 CD36 MMP2 SMAD2 SMAD3 TGFB1
11 respiratory system MP:0005388 9.55 MMP2 SMAD2 TGFB1 TGFB3 TIMP1
12 vision/eye MP:0005391 9.1 CD36 MMP2 SMAD2 SMAD3 TGFB1 TGFB3

Drugs & Therapeutics for Hypertrophic Scars

Drugs for Hypertrophic Scars (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
2
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 5311051 32798
3
Petrolatum Approved, Investigational Phase 4,Early Phase 1 8009-03-8
4
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
5
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
6
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
7
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
8
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
11
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
12
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
13
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
14
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
15
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
16 Tocotrienol Investigational Phase 4 6829-55-6
17
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
18 Micronutrients Phase 4,Phase 2,Early Phase 1
19 Trace Elements Phase 4,Phase 2,Early Phase 1
20 Dermatologic Agents Phase 4,Phase 2,Early Phase 1
21 Emollients Phase 4,Phase 3,Early Phase 1
22 glucocorticoids Phase 4,Phase 3
23 Protective Agents Phase 4,Phase 2,Phase 3,Early Phase 1
24 Anti-Infective Agents Phase 4,Phase 3,Phase 1
25 Antioxidants Phase 4,Phase 2,Phase 3
26 Vitamins Phase 4,Phase 2
27 Anesthetics Phase 4,Not Applicable
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
29 Hormone Antagonists Phase 4,Phase 2,Phase 3
30 Anti-Inflammatory Agents Phase 4
31 Hormones Phase 4,Phase 2,Phase 3
32 Tocopherols Phase 4
33 Hydrocortisone-17-butyrate Phase 4
34 Tocotrienols Phase 4
35 Central Nervous System Depressants Phase 4
36 Hydrocortisone 17-butyrate 21-propionate Phase 4
37 Anti-Infective Agents, Local Phase 4
38 Cortisol succinate Phase 4
39 Antineoplastic Agents, Hormonal Phase 4
40 Antiemetics Phase 4
41 Gastrointestinal Agents Phase 4
42 Prednisolone acetate Phase 4
43 Neuroprotective Agents Phase 4
44 Autonomic Agents Phase 4
45 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
46 Methylprednisolone acetate Phase 4
47 Natriuretic Agents Phase 4
48 diuretics Phase 4
49 Chlorhexidine gluconate Phase 4
50 Anti-Arrhythmia Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 90)
# Name Status NCT ID Phase Drugs
1 An Investigator-blind Multi-center Prospective Study for the Efficacy and Safety of Silicon Gel (Dermatix) Unknown status NCT01004536 Phase 4
2 Silicone Gel to Improve Scar in Microtia Patients Unknown status NCT02518035 Phase 4 Silicone Gel
3 Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Completed NCT02487212 Phase 4 0.05% Clobetasol propionate;Petrolatum gel
4 Effect of Silicone Gel Versus Contractubex Phonophoresis for Post-burn Hypertrophic Scars Completed NCT03777891 Phase 4
5 A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars Completed NCT00754247 Phase 4 0.5% hydrocortisone, silicone, vitamin E lotion;Onion extract gel;Cetearyl alcohol lotion
6 Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Completed NCT01078428 Phase 4
7 1540nm Non Ablative Fractional Laser Treatment of Scars Completed NCT01056211 Phase 4
8 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
9 Prevention and Treatment of Stretch Marks With Stratamark™ Completed NCT03377231 Phase 4
10 Facial Lipoatrophy Correction Experience With SCULPTRA ("FACES" Study) Completed NCT00360932 Phase 4
11 Pilot Study of a Novel 532nm KTP Laser for the Treatment of Fresh Surgical Scars Completed NCT01789346 Phase 4
12 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
13 Scars After Central Venous Catheters Unknown status NCT01113125 Phase 3 Betamethason-17-valerate and fusidic acid;Fusidic Acid
14 Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars Unknown status NCT01861119 Phase 3 Silicone gel Kelo-cort™;;Onion extract gel Contractubex™
15 DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction Unknown status NCT02206477 Phase 2, Phase 3 Dimethyl Sulfoxide;Saline 0.9%
16 Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients Completed NCT03376620 Phase 3 1,4-Diaminobutane;10% Urea cream
17 CICATRIX in the Treatment of Hypertrophic Scars and Keloids Scars Completed NCT00993005 Phase 3
18 Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection Completed NCT02886988 Phase 2, Phase 3 Botulinum toxin type A;normal saline
19 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
20 Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma Completed NCT01383187 Phase 2, Phase 3
21 Botulinum Toxin to Improve Results in Epicanthoplasty Recruiting NCT03294382 Phase 3 Botulinum toxin type A;Placebo
22 Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Active, not recruiting NCT03038594 Phase 2, Phase 3 Somatropin;0.09% Saline Solution
23 The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair Enrolling by invitation NCT03219580 Phase 3 5-Fluorouracil;Normal Saline Flush, 0.9% Injectable Solution
24 PRP Use in Diabetic Patients Undergoing Cesarean Section Not yet recruiting NCT03602950 Phase 2, Phase 3
25 Intron A for the Treatment of Hypertrophic Scar Withdrawn NCT00686478 Phase 3 interferon alpha 2b
26 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
27 The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Acne Scars Unknown status NCT02126657 Phase 2 70% glycolic acid
28 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults Completed NCT02030275 Phase 2 RXI-109;Placebo
29 Safety and Efficacy Study of PF-06473871 to Reduce Hypertrophic Scars From Recurring Post-Revision Surgery Completed NCT01730339 Phase 2 PF-06473871;PF-06473871
30 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
31 Safety and Efficacy of EXC 001 in Subjects Who Have Participated in Prior Studies of EXC 001 Completed NCT01494922 Phase 2 EXC 001 (currently called PF-06473871)
32 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
33 Treatment of Hypertrophic Scars With Intradermal Botox Recruiting NCT03631368 Phase 2 Botox
34 A Randomized Study to Evaluate the Safety and Efficacy of Various Doses of STP705 in Subjects With Hypertrophic Scar Recruiting NCT02956317 Phase 1, Phase 2 STP705;Placebo
35 A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Revised Hypertrophic Scars Active, not recruiting NCT02246465 Phase 2 RXI-109
36 Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention Not yet recruiting NCT03795116 Phase 2
37 A Phase 2 Extension Study To Enroll Subjects Who Were Enrolled In B5301001 Study Terminated NCT02205476 Phase 2 PF-06473871;PF-06473871
38 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2 ICX‐RHY‐013
39 Juvista (Avotermin) in Breast Reduction Surgery Scars Terminated NCT00432328 Phase 2 Avotermin
40 Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars Withdrawn NCT02546076 Phase 2
41 Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis Unknown status NCT01858038 Phase 1
42 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
43 Study to Investigate the Pharmacokinetics, Safety, and Tolerability of BMT101 in Healthy Male Volunteers Completed NCT03133130 Phase 1 BMT101;Placebo
44 FS2 Safety and Tolerability Study in Healthy Volunteers Completed NCT02340325 Phase 1 Acute Application of kynurenic acid cream;Chronic application of kynurenic acid cream
45 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Completed NCT02639117 Phase 1 Vismodegib
46 Hypertrophic Scar Prevention by Novel Topical Gel Application Recruiting NCT03403621 Phase 1 Pentamidine Isethionate;Silicone Gels
47 A Study to Evaluate Safety and PK Profiles of OLX10010 in Healthy Subjects Recruiting NCT03569267 Phase 1 OLX10010;Placebo
48 To Study Gene Expression of Postburn Hypertrophic Scar Unknown status NCT01676168
49 Prevention of Hypertrophic Scars or Keloids Unknown status NCT00849004 Not Applicable
50 The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial Unknown status NCT02168634 Not Applicable Botulinum Toxins;Placebo

Search NIH Clinical Center for Hypertrophic Scars

Genetic Tests for Hypertrophic Scars

Anatomical Context for Hypertrophic Scars

MalaCards organs/tissues related to Hypertrophic Scars:

41
Skin, Liver, Endothelial, Lung, Heart

Publications for Hypertrophic Scars

Articles related to Hypertrophic Scars:

(show top 50) (show all 480)
# Title Authors Year
1
Treatment Strategies for Hypopigmentation in the Context of Burn Hypertrophic Scars. ( 29464168 )
2018
2
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240586 )
2018
3
Insights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ? ( 29240593 )
2018
4
Assessment of Ablative Fractional CO2 Laser and Er:YAG Laser to Treat Hypertrophic Scars in a Red Duroc Pig Model. ( 29718376 )
2018
5
Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. ( 29498630 )
2018
6
Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial. ( 29886113 )
2018
7
Reply: Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 29485591 )
2018
8
Autologous chyle fat grafting for the treatment of hypertrophic scars and scar-related conditions. ( 29523181 )
2018
9
The effects of platelet-rich plasma on hypertrophic scars fibroblasts. ( 29781178 )
2018
10
I^-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. ( 29476776 )
2018
11
The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29401161 )
2018
12
Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 29485590 )
2018
13
Perspectives for applying the additional study methods for diagnostics optimization of postoperative hypertrophic scars of the head and neck. ( 29783207 )
2018
14
Comparison of the effectiveness of pulsed dye laser vs pulsed dye laser combined with ultrapulse fractional CO<sub>2</sub>laser in the treatment of immature red hypertrophic scars. ( 29392869 )
2018
15
MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. ( 29434768 )
2018
16
Commentary on The Cellular Response of Keloids and Hypertrophic Scars to Botulinum Toxin A: A Comprehensive Literature Review. ( 29309344 )
2018
17
Clinical Outcome of 1064-nm Picosecond Neodymium-Doped Yttrium Aluminium Garnet Laser for the Treatment of Hypertrophic Scars. ( 29757022 )
2018
18
Evaluation of the therapeutic effect of micro-plasma radio frequency on hypertrophic scars in rabbit ears. ( 30003425 )
2018
19
Anti-CTGF Oligonucleotide Reduces Severity of Postsurgical Hypertrophic Scars in a Randomized, Double-Blind, Within-Subject, Placebo-Controlled Study. ( 30045185 )
2018
20
Losartan ointment relieves hypertrophic scars and keloid: A pilot study. ( 30099811 )
2018
21
Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars. ( 30114861 )
2018
22
MicroRNA-663 regulates the proliferation of fibroblasts in hypertrophic scars via transforming growth factor-β1. ( 30116380 )
2018
23
Intense pulsed light vs silicone gel sheet in the management of hypertrophic scars: an interventional comparative trial in the Indian population. ( 30300020 )
2018
24
High‑throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars. ( 30320389 )
2018
25
Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( 30340861 )
2018
26
Treatment of Hypertrophic Scars Using Laser-Assisted Corticosteroid Versus Laser-Assisted 5-Fluorouracil Delivery. ( 30365461 )
2018
27
Electrophotobiomodulation in the treatment of facial post-burn hypertrophic scars in pediatric patients. ( 30374265 )
2018
28
Two Cases of Granular Cell Tumors that Clinically Mimicked Hypertrophic Scars and Keloids. ( 30464145 )
2018
29
The Efficacy of Anti-VEGF Antibody-Modified Liposomes Loaded with Paeonol in the Prevention and Treatment of Hypertrophic Scars. ( 30512972 )
2018
30
Duration of Scar Maturation: Retrospective Analyses of 361 Hypertrophic Scars Over 5 Years. ( 30531549 )
2018
31
Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review. ( 30548742 )
2018
32
Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. ( 29069016 )
2017
33
Intralesional cryotherapy for hypertrophic scars and keloids: a review. ( 29799581 )
2017
34
Laser Modulation of Hypertrophic Scars: Technique and Practice. ( 28888301 )
2017
35
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. ( 28287424 )
2017
36
Techniques for Optimizing Surgical Scars, Part 2: Hypertrophic Scars and Keloids. ( 29282183 )
2017
37
Clinical efficacy of utilizing Ultrapulse CO<sub>2</sub>combined with fractional CO<sub>2</sub>laser for the treatment of hypertrophic scars in Asians-A prospective clinical evaluation. ( 29058830 )
2017
38
Pleiotropic FTY720 Is a Specific and Potent Therapy for Hypertrophic Scars. ( 28288846 )
2017
39
Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model. ( 28654594 )
2017
40
Heterotopic Ossification and Hypertrophic Scars. ( 28888300 )
2017
41
Assessing blood flow, microvasculature, erythema and redness in hypertrophic scars: A cross sectional study showing different features that require precise definitions. ( 28153584 )
2017
42
Hypertrophic Scars: Are Vitamins and Inflammatory Biomarkers Related with the Pathophysiology of Wound Healing? ( 28569361 )
2017
43
Autologous fat grafting in keloids and hypertrophic scars: a review. ( 29799555 )
2017
44
A Comparison of Gene Expression of Decorin and MMP13 in Hypertrophic Scars Treated With Calcium Channel Blocker, Steroid, and Interferon: A Human-Scar-Carrying Animal Model Study. ( 28009689 )
2017
45
Role of Hyaluronidase in the Treatment of Hypertrophic Scars. ( 29140867 )
2017
46
Introduction to Special Issue on Hypertrophic Scars and Keloids. ( 28009688 )
2017
47
Evaluating accuracy and reliability of active stereophotogrammetry using MAVIS III Wound Camera for three-dimensional assessment of hypertrophic scars. ( 28363664 )
2017
48
Review of Silicone Gel Sheeting and Silicone Gel for the Prevention of Hypertrophic Scars and Keloids. ( 28570253 )
2017
49
Evidence of invasive and non-invasive treatment modalities for hypertrophic scars: A systematic review. ( 28056485 )
2017
50
Biocompatible 5-Aminolevulinic Acid/Au Nanoparticle-Loaded Ethosomal Vesicles for In Vitro Transdermal Synergistic Photodynamic/Photothermal Therapy of Hypertrophic Scars. ( 29247361 )
2017

Variations for Hypertrophic Scars

Expression for Hypertrophic Scars

Search GEO for disease gene expression data for Hypertrophic Scars.

Pathways for Hypertrophic Scars

Pathways related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 BMP6 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
2
Show member pathways
13.4 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
3
Show member pathways
13.37 CD36 KRT16 MMP2 SMAD2 SMAD3 TGFB1
4
Show member pathways
13.17 BMP6 SMAD3 TGFB1 TGFB3 TIMP1
5
Show member pathways
12.93 KRT16 MMP2 SMAD2 SMAD3 TGFB1
6
Show member pathways
12.92 BMP6 TGFB1 TGFB3 TIMP1
7
Show member pathways
12.91 BMP6 TGFB1 TGFB3 TIMP1
8
Show member pathways
12.88 SMAD2 SMAD3 TGFB1 TGFB3
9
Show member pathways
12.75 SMAD2 SMAD3 TGFB1 TGFB3
10 12.72 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
11
Show member pathways
12.66 SMAD2 SMAD3 TGFB1 TGFB3
12
Show member pathways
12.64 MMP2 TGFB1 TGFB3 TIMP1
13
Show member pathways
12.61 BMP6 TGFB1 TGFB3 TIMP1
14
Show member pathways
12.51 SMAD2 SMAD3 TGFB1 TGFB3
15
Show member pathways
12.43 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
16
Show member pathways
12.38 SMAD2 SMAD3 TGFB1 TGFB3
17 12.33 SMAD2 SMAD3 TGFB1 TGFB3
18
Show member pathways
12.29 BMP6 TGFB1 TGFB3 TIMP1
19 12.27 SMAD2 SMAD3 TGFB1 TGFB3
20 12.2 MMP2 SMAD2 TGFB1
21
Show member pathways
12.19 SMAD2 SMAD3 TGFB1
22
Show member pathways
12.18 BMP6 TGFB1 TGFB3 TIMP1
23 12.15 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
24
Show member pathways
12.13 SMAD2 SMAD3 TGFB1
25 12.1 SMAD2 SMAD3 TGFB1 TGFB3
26 12.07 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
27
Show member pathways
12.04 MMP2 SMAD3 TGFB1
28
Show member pathways
12.02 SMAD2 SMAD3 TGFB1 TGFB3
29 12.02 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
30 11.99 SMAD2 SMAD3 TGFB1
31
Show member pathways
11.98 SMAD2 SMAD3 TGFB1 TGFB3
32 11.92 CD36 MMP2 TGFB1 TIMP1
33
Show member pathways
11.89 BMP6 SMAD2 SMAD3 TGFB1 TGFB3 TIMP1
34
Show member pathways
11.82 SMAD2 SMAD3 TGFB1
35 11.81 SMAD2 SMAD3 TGFB1 TGFB3
36 11.76 MMP2 TGFB1 TGFB3 TIMP1
37
Show member pathways
11.72 SMAD2 SMAD3 TGFB1
38 11.69 SMAD2 SMAD3 TGFB1
39 11.68 CD36 TGFB1 TGFB3
40 11.66 BMP6 TGFB1 TGFB3 TIMP1
41
Show member pathways
11.66 SMAD2 SMAD3 TGFB1
42 11.65 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
43 11.63 MMP2 SMAD2 SMAD3
44 11.6 MMP2 TGFB1 TIMP1
45 11.56 SMAD2 SMAD3 TGFB1
46 11.52 BMP6 MMP2 SMAD2 SMAD3 TGFB1 TGFB3
47 11.49 SMAD2 SMAD3 TGFB1 TGFB3
48 11.48 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
49 11.47 CD36 TGFB1 TGFB3
50
Show member pathways
11.46 MMP2 SMAD2 SMAD3 TGFB1 TGFB3

GO Terms for Hypertrophic Scars

Cellular components related to Hypertrophic Scars according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 BMP6 CD36 MMP2 TGFB1 TGFB3 TIMP1
2 collagen-containing extracellular matrix GO:0062023 9.5 MMP2 TGFB1 TGFB3
3 SMAD protein complex GO:0071141 9.16 SMAD2 SMAD3
4 platelet alpha granule lumen GO:0031093 9.13 TGFB1 TGFB3 TIMP1
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3

Biological processes related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 SMAD2 SMAD3 TGFB1 TGFB3
2 positive regulation of gene expression GO:0010628 9.99 CD36 SMAD2 SMAD3 TGFB1
3 cytokine-mediated signaling pathway GO:0019221 9.96 CD36 MMP2 TGFB1 TIMP1
4 regulation of apoptotic process GO:0042981 9.92 BMP6 TGFB1 TGFB3
5 negative regulation of gene expression GO:0010629 9.91 CD36 SMAD2 TGFB1
6 in utero embryonic development GO:0001701 9.89 SMAD2 SMAD3 TGFB3
7 aging GO:0007568 9.88 KRT16 TGFB1 TGFB3 TIMP1
8 response to hypoxia GO:0001666 9.88 MMP2 SMAD3 TGFB1 TGFB3
9 cell development GO:0048468 9.81 BMP6 TGFB1 TGFB3
10 regulation of MAPK cascade GO:0043408 9.8 BMP6 TGFB1 TGFB3
11 platelet degranulation GO:0002576 9.8 CD36 TGFB1 TGFB3 TIMP1
12 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.78 BMP6 TGFB1 TGFB3
13 ureteric bud development GO:0001657 9.77 SMAD2 SMAD3 TGFB1
14 positive regulation of protein secretion GO:0050714 9.77 BMP6 TGFB1 TGFB3
15 transforming growth factor beta receptor signaling pathway GO:0007179 9.76 SMAD2 SMAD3 TGFB1 TGFB3
16 negative regulation of fat cell differentiation GO:0045599 9.75 SMAD3 TGFB1
17 T cell activation GO:0042110 9.75 SMAD3 TGFB1
18 positive regulation of cell division GO:0051781 9.74 TGFB1 TGFB3
19 extrinsic apoptotic signaling pathway GO:0097191 9.74 SMAD3 TGFB1
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 CD36 SMAD3
21 embryonic cranial skeleton morphogenesis GO:0048701 9.74 SMAD2 SMAD3
22 gastrulation GO:0007369 9.74 SMAD2 SMAD3
23 mammary gland development GO:0030879 9.73 TGFB1 TGFB3
24 negative regulation of mitotic cell cycle GO:0045930 9.73 SMAD3 TGFB1
25 response to progesterone GO:0032570 9.73 TGFB1 TGFB3
26 digestive tract development GO:0048565 9.73 TGFB1 TGFB3
27 mesoderm formation GO:0001707 9.73 SMAD2 SMAD3
28 positive regulation of protein import into nucleus GO:0042307 9.73 SMAD3 TGFB1
29 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 SMAD2 SMAD3 TGFB1 TGFB3
30 developmental growth GO:0048589 9.72 SMAD2 SMAD3
31 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.72 SMAD3 TGFB1
32 positive regulation of collagen biosynthetic process GO:0032967 9.72 TGFB1 TGFB3
33 adrenal gland development GO:0030325 9.71 SMAD2 SMAD3
34 embryonic pattern specification GO:0009880 9.71 SMAD2 SMAD3
35 positive regulation of chondrocyte differentiation GO:0032332 9.71 BMP6 SMAD3
36 signal transduction involved in regulation of gene expression GO:0023019 9.71 SMAD2 SMAD3
37 face morphogenesis GO:0060325 9.71 MMP2 TGFB1 TGFB3
38 activin receptor signaling pathway GO:0032924 9.7 SMAD2 SMAD3
39 secondary palate development GO:0062009 9.7 SMAD2 TGFB3
40 endoderm development GO:0007492 9.7 SMAD2 SMAD3 TGFB1
41 lens fiber cell differentiation GO:0070306 9.69 SMAD3 TGFB1
42 cell-cell junction organization GO:0045216 9.69 SMAD3 TGFB1 TGFB3
43 cell activation GO:0001775 9.68 TGFB1 TIMP1
44 nodal signaling pathway GO:0038092 9.68 SMAD2 SMAD3
45 primary miRNA processing GO:0031053 9.68 SMAD2 SMAD3
46 response to cholesterol GO:0070723 9.68 SMAD2 TGFB1
47 salivary gland morphogenesis GO:0007435 9.67 TGFB1 TGFB3
48 embryonic foregut morphogenesis GO:0048617 9.67 SMAD2 SMAD3
49 pericardium development GO:0060039 9.67 SMAD2 SMAD3
50 response to laminar fluid shear stress GO:0034616 9.66 TGFB1 TGFB3

Molecular functions related to Hypertrophic Scars according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 BMP6 TGFB1 TGFB3 TIMP1
2 protein heterodimerization activity GO:0046982 9.65 BMP6 SMAD2 SMAD3 TGFB1 TGFB3
3 R-SMAD binding GO:0070412 9.52 SMAD2 SMAD3
4 transforming growth factor beta binding GO:0050431 9.51 CD36 TGFB3
5 enhancer binding GO:0035326 9.49 SMAD2 SMAD3
6 co-SMAD binding GO:0070410 9.48 SMAD2 SMAD3
7 primary miRNA binding GO:0070878 9.46 SMAD2 SMAD3
8 growth factor activity GO:0008083 9.46 BMP6 TGFB1 TGFB3 TIMP1
9 type II transforming growth factor beta receptor binding GO:0005114 9.43 TGFB1 TGFB3
10 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.4 SMAD2 SMAD3
11 type III transforming growth factor beta receptor binding GO:0034714 9.32 TGFB1 TGFB3
12 type I transforming growth factor beta receptor binding GO:0034713 9.13 SMAD2 TGFB1 TGFB3
13 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 SMAD2 SMAD3 TGFB1 TGFB3

Sources for Hypertrophic Scars

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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38 LifeMap
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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